Academic literature on the topic 'Imaging biomarker validation'
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Journal articles on the topic "Imaging biomarker validation"
Kammer, Michael N., Stephen A. Deppen, Sanja Antic, S. M. Jamshedur Rahman, Rosana Eisenberg, Fabien Maldonado, Melinda C. Aldrich, et al. "The impact of the lung EDRN-CVC on Phase 1, 2, & 3 biomarker validation studies." Cancer Biomarkers 33, no. 4 (April 18, 2022): 449–65. http://dx.doi.org/10.3233/cbm-210382.
Full textKammer, Michael N., Stephen A. Deppen, Sanja Antic, S. M. Jamshedur Rahman, Rosana Eisenberg, Fabien Maldonado, Melinda C. Aldrich, et al. "The impact of the lung EDRN-CVC on Phase 1, 2, & 3 biomarker validation studies." Cancer Biomarkers 33, no. 4 (April 18, 2022): 449–65. http://dx.doi.org/10.3233/cbm-210382.
Full textDe Jesus, J. R., and Marco Arruda. "Human disease biomarkers: challenges, advances, and trends in their validation." Journal of Integrated OMICS 11, no. 2 (December 29, 2021): 16–28. http://dx.doi.org/10.5584/jiomics.v11i2.207.
Full textSchwamborn, Kristina. "Imaging mass spectrometry in biomarker discovery and validation." Journal of Proteomics 75, no. 16 (August 2012): 4990–98. http://dx.doi.org/10.1016/j.jprot.2012.06.015.
Full textAhmed, Aqsa, Waleed AL-Ansi, Samra Basharat, Ye Li, and Zhonghu Bai. "Validation of Protein Biomarker Candidates for Diagnosis of HBV induced HCC." International Journal of Advances in Agricultural Science and Technology 9, no. 3 (March 30, 2022): 9–42. http://dx.doi.org/10.47856/ijaast.2022.v09i03.002.
Full textD’Agostino, Maria-Antonietta, Maarten Boers, John Kirwan, Désirée van der Heijde, Mikkel Østergaard, Georg Schett, Robert B. Landewé, et al. "Updating the OMERACT Filter: Implications for Imaging and Soluble Biomarkers." Journal of Rheumatology 41, no. 5 (March 1, 2014): 1016–24. http://dx.doi.org/10.3899/jrheum.131313.
Full textPalermo, Giovanni, Sara Giannoni, Gabriele Bellini, Gabriele Siciliano, and Roberto Ceravolo. "Dopamine Transporter Imaging, Current Status of a Potential Biomarker: A Comprehensive Review." International Journal of Molecular Sciences 22, no. 20 (October 18, 2021): 11234. http://dx.doi.org/10.3390/ijms222011234.
Full textO’Rourke, Matthew B., Ben R. Roediger, Christopher J. Jolly, Ben Crossett, Matthew P. Padula, and Phillip M. Hansbro. "Viral Biomarker Detection and Validation Using MALDI Mass Spectrometry Imaging (MSI)." Proteomes 10, no. 3 (September 13, 2022): 33. http://dx.doi.org/10.3390/proteomes10030033.
Full textObuchowski, Nancy A., Erick M. Remer, Ken Sakaie, Erika Schneider, Robert J. Fox, Kunio Nakamura, Ricardo Avila, and Alexander Guimaraes. "Importance of incorporating quantitative imaging biomarker technical performance characteristics when estimating treatment effects." Clinical Trials 18, no. 2 (January 10, 2021): 197–206. http://dx.doi.org/10.1177/1740774520981934.
Full textWeber, Wolfgang A. "Positron Emission Tomography As an Imaging Biomarker." Journal of Clinical Oncology 24, no. 20 (July 10, 2006): 3282–92. http://dx.doi.org/10.1200/jco.2006.06.6068.
Full textDissertations / Theses on the topic "Imaging biomarker validation"
Coe, Peter. "Validation and early qualification of pancreatic fat deposition as an imaging biomarker of pancreatic cancer risk." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/validation-and-early-qualification-of-pancreatic-fat-deposition-as-an-imaging-biomarker-of-pancreatic-cancer-risk(ff38a95b-f135-4bfe-b901-80d79c388974).html.
Full textPrevost, Valentin. "Validation du transfert d'aimantation inhomogène (ihMT) comme nouveau biomarqueur IRM de la myéline." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0037/document.
Full textMagnetic resonance imaging (MRI) is a non-invasive medical imaging technique, widely used to explore soft tissues. Advanced and innovated MRI techniques have been developed to improve the specificity of conventional MR sequences thus allowing accessing new information. A particularly important research topic concerns the ability to in vivo access myelin information. Myelin is a major component of the central nervous system responsible for a good nerve conduction. Myelin alteration occurs in multiple sclerosis, one of the main cause for young adult permanent disability. However, myelin MRI is challenged by the very short relaxation time, T2, of myelin protons. Inhomogeneous magnetization transfer (ihMT) is a recent technique, which allows assessing macromolecular tissue component by exploiting their dipolar order relaxation properties, characterized by the time constant T1D. The objective of this thesis concerned the validation of ihMT as a myelin biomarker and the evaluation of the specificity of ihMT for myelin on mouse models
Yeh, Hsin-Hsien. "Utility and validation of the histone deacetylase (HDAC) substrate, [18F]FAHA, as a positron emission tomography (PET) imaging biomarker in non-human primates and HD transgenic mice for evaluation of neurodegenerative diseases and HDAC inhibitor treatment." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/utility-and-validation-of-the-histone-deacetylase-hdac-substrate-18ffaha-as-a-positron-emission-tomography-pet-imaging-biomarker-in-nonhuman-primates-and-hd-transgenic-mice-for-evaluation-of-neurodegenerative-diseases-and-hdac-inhibitor-treatment(69cbe9a1-aa64-45d6-947f-9368eabb071c).html.
Full textPoncelet, Lauranne. "Utilisation de l'imagerie par spectrométrie de masse et son optimisation au cours du processus de développement de médicaments." Thesis, Lille, 2020. http://www.theses.fr/2020LILUS032.
Full textResearch and development (R&D) in the pharmaceutical industry is a crucial step for the discovery of new drugs or biomarkers. The development of new innovative treatments is a key driver of progress in the management of many diseases, such as periodontitis or immuno-oncology. This thesis work is initially interested in the place of mass spectrometry imaging using a matrix-assisted laser desorption ionization source (MALDI-MSI) during the development of new drugs, followed by its evolution reviewed (matrices, instruments and software) before illustrating several developments made with this technology to improve the detection of the compounds of interest (drugs / biomarkers), but also the quality of the results (quality of the samples or the quality of the analyze) with a view to standardization. Also, the implementation of quality controls and the validation of the quantification method improves the quality of the results. These developments then help pharmaceutical industries in the R&D stages, allowing them to combine this technology with their arsenal, in order to save time and money during the development stages of new drug candidates
Aguado, Sarrió Eric. "Application of multivariate image analysis to prostate cancer for improving the comprehension of the related physiological phenomena and the development and validation of new imaging biomarkers." Doctoral thesis, 2020. http://hdl.handle.net/10251/134023.
Full text[CAT] El increment de la esperança de vida en la població per damunt dels 50 anys està generant un major nombre de casos detectats de càncer de pròstata (CaP). Per aquest motiu, els recursos es destinen al diagnòstic en etapes primerenques i al tractament efectiu. Tot i la multitud de estudis basats en biomarcadors y discriminació histològica, es difícil diferenciar amb efectivitat els casos de CaP que tenen baixa agressivitat dels que progressaran y acabaran produint mortalitat o una disminució en la esperança de vida del pacient. Amb el objectiu de millorar el diagnòstic, localització y gradació dels tumors malignes, les tècniques de imatge per Ressonància Magnètica (MRI) son els mètodes més adequats per al estudi del càncer, proporcionant metodologies de diagnòstic no-invasius, sensibles y específiques basades en seqüències morfològiques (T2w) y funcionals (perfusió de la sang y difusió del aigua). Les diferents característiques i paràmetres extrets de aquestes seqüències, coneguts com biomarcadors d'imatge, poden avaluar les diferències associades al desenvolupament dels processos tumorals. Primer, amb els models farmacocinétics per a estudiar angiogènesis (perfusió) y segon, amb els models mono- i bi-exponencials per a estudiar la caiguda de la senyal en difusió amb el objectiu de estudiar la cel·lularització. Normalment, aquests biomarcadors d'imatge s'analitzen de forma "univariant", sense aprofitar la informació de las estructures de correlació interna que existeixen entre ells. Una forma de millorar aquest anàlisis es mitjançant la aplicació de las tècniques estadístiques aportades pel Anàlisis Multivariant de Imatges (MIA), obtenint estructures (latents) simplificades què ajuden a entendre la relació entre els paràmetres (variables) i els seus processos fisiològics, a més de reduir la incertesa en la estimació dels biomarcadors. En aquesta tesis, s'han desenvolupat nous biomarcadors d'imatge per a perfusió i difusió amb la aplicació de alguna de las ferramentes de MIA com la Resolució Multivariant de Corbes i Mínims Quadrats Alterns (MCR-ALS), obtenint paràmetres què tenen interpretació clínica directa. A continuació, els mètodes basats en mínims quadrats parcials (PLS) s'han aplicat per a estudiar la capacitat de classificació d'aquests biomarcadors. En primer lloc, els biomarcadors de perfusió s'han utilitzat per a la detecció de tumors (control contra lesió). Posteriorment, la combinació de perfusió + difusió + T2 s'ha utilitzat per a estudiar agressivitat tumoral amb la aplicació de mètodes PLS multi-bloc, en concret (seqüencial) SMB-PLS. Els resultats mostren què els biomarcadors de perfusió obtinguts mitjançant MCR són millors què els paràmetres farmacocinètics en la diferenciació de la lesió. En lo què es refereix al estudi de la agressivitat tumoral, la combinació dels biomarcadors de difusió (utilitzant els dos mètodes: models paramètrics i MCR) i els valors de T2w normalitzats proporcionaren els millors resultats. En conclusió, MIA es pot aplicar a les seqüències morfològiques i funcionals de ressonància magnètica per a millorar el diagnòstic i el estudi de l'agressivitat dels tumors en pròstata. Obtenint nous paràmetres quantitatius y combinant-los amb els biomarcadors més utilitzats en el ambient clínic.
[EN] The increase in life expectancy and population with age higher than 50 years is producing a major number of detected cases of prostate cancer (PCa). For this reason, the resources are focused in the early diagnosis and effective treatment. In spite of multiple studies with histologic discriminant biomarkers, it is hard to clearly differentiate the low aggressiveness PCa cases from those that will progress and produce mortality or rather a decrease in the life expectancy. With the objective of improving the diagnosis, location and gradation of the malignant tumors, Magnetic Resonance Imaging (MRI) has come up as the most appropriate image acquisition technique for cancer studies, which provides a non-invasive, sensitive and specific diagnosis, based on morphological and functional (blood perfusion and water diffusion) sequences. The different characteristics and parameters extracted from these sequences, known as imaging biomarkers, can evaluate the different processes associated to tumor development, like pharmacokinetic modeling for angiogenesis assessment (perfusion) or mono- and bi-exponential signal decay modeling for cellularization (diffusion). Normally, these imaging biomarkers are analyzed in a "univariate" way, without taking advantage of the internal correlation structures among them. One way to improve this analysis is by applying Multivariate Image Analysis (MIA) statistical techniques, obtaining simplified (latent) structures that help to understand the relation between parameters (variables) and the inner physiological processes, moreover reducing the uncertainty in the estimation of the biomarkers. In this thesis, new imaging biomarkers are developed for perfusion and diffusion by applying MIA tools like Multivariate Curve Resolution Alternating Least Squares (MCR-ALS), obtaining parameters with direct clinical interpretation. Partial Least Squares (PLS) based methods are then used for studying the classification capability of these biomarkers. First, perfusion imaging biomarkers have been tested for tumor detection (control vs lesion). Then, diffusion + perfusion have been combined to study tumor aggressiveness by applying PLS-multiblock methods (SMB-PLS). The results showed that MCR-based perfusion biomarkers performed better than state-of-the-art pharmacokinetic parameters for lesion differentiation. Regarding the assessment of tumor aggressiveness, the combination of diffusion-based imaging biomarkers (using both the parametric models and MCR) and normalized T2-weighted measurements provided the best discriminating outcome, while perfusion was not needed as it did not supply additional information. In conclusion, MIA can be applied to morphologic and functional MRI to improve the diagnosis and aggressiveness assessment of prostate tumors by obtaining new quantitative parameters and combining them with state-of-the-art imaging biomarkers.
Aguado Sarrió, E. (2019). Application of multivariate image analysis to prostate cancer for improving the comprehension of the related physiological phenomena and the development and validation of new imaging biomarkers [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/134023
TESIS
Books on the topic "Imaging biomarker validation"
Markman, John D. Diagnostic and Clinical Scales for Peripheral Neuropathy. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0120.
Full textRider, Lisa G., and Frederick W. Miller. Outcome assessment in the idiopathic inflammatory myopathies. Edited by Hector Chinoy and Robert Cooper. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198754121.003.0016.
Full textBook chapters on the topic "Imaging biomarker validation"
Sakka, Andreas P., and James R. Whiteside. "Biomarker Discovery and Medical Diagnostic Imaging." In Biomarker Validation, 59–73. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527680658.ch4.
Full textManikis, George C., Nickolas Papanikolaou, and Celso Matos. "Validating the Imaging Biomarker: The Proof of Efficacy and Effectiveness." In Imaging Biomarkers, 115–22. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43504-6_10.
Full textSanduleanu, Sebastian, Simon Keek, Lars Hoezen, and Philippe Lambin. "Biomarkers for Hypoxia, HPVness, and Proliferation from Imaging Perspective." In Critical Issues in Head and Neck Oncology, 13–20. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_2.
Full textJerome, Neil Peter, and João S. Periquito. "Analysis of Renal Diffusion-Weighted Imaging (DWI) Using Apparent Diffusion Coefficient (ADC) and Intravoxel Incoherent Motion (IVIM) Models." In Methods in Molecular Biology, 611–35. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_37.
Full textDamian, Ioana, and Simona Delia Nicoară. "Local Inflammatory Biomarkers and Potential Inflammation-Targeting Therapies in Diabetic Retinopathy." In Diabetic Eye Disease - From Therapeutic Pipeline to the Real World. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.99807.
Full textConference papers on the topic "Imaging biomarker validation"
Paniagua, Beatriz, Antonio C. Ruellas, Erika Benavides, Steve Marron, Larry Wolford, and Lucia Cevidanes. "Validation of CBCT for the computation of textural biomarkers." In SPIE Medical Imaging, edited by Barjor Gimi and Robert C. Molthen. SPIE, 2015. http://dx.doi.org/10.1117/12.2081859.
Full textWiemker, Rafael, Merlijn Sevenster, Heber MacMahon, Feng Li, Sandeep Dalal, Amir Tahmasebi, and Tobias Klinder. "Automated assessment of imaging biomarkers for the PanCan lung cancer risk prediction model with validation on NLST data." In SPIE Medical Imaging, edited by Samuel G. Armato and Nicholas A. Petrick. SPIE, 2017. http://dx.doi.org/10.1117/12.2253905.
Full textVogt, William C., Congxian Jia, Keith A. Wear, Brian S. Garra, and Joshua Pfefer. "Design and phantom-based validation of a bimodal ultrasound-photoacoustic imaging system for spectral detection of optical biomarkers." In SPIE BiOS, edited by Ramesh Raghavachari, Rongguang Liang, and T. Joshua Pfefer. SPIE, 2015. http://dx.doi.org/10.1117/12.2082847.
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