Academic literature on the topic 'Imaging and Therapy'

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Journal articles on the topic "Imaging and Therapy"

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Ciarmiello, Andrea, and Luigi Mansi. "Inaugural Editorial Review – Nuclear Medicine, Diagnostic Imaging and Therapy." Journal of Diagnostic Imaging in Therapy 2, no. 1 (February 2, 2015): 1–8. http://dx.doi.org/10.17229/jdit.2015-0202-011.

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Ciarmiello, Andrea, and Luigi Mansi. "Editorial Review 2015 – Nuclear Medicine, Diagnostic Imaging and Therapy." Journal of Diagnostic Imaging in Therapy 3, no. 1 (January 16, 2016): 1–6. http://dx.doi.org/10.17229/jdit.2016-0116-020.

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Ciarmiello, Andrea, and Luigi Mansi. "Editorial Review 2016 – Nuclear Medicine, Diagnostic Imaging and Therapy." Journal of Diagnostic Imaging in Therapy 4, no. 1 (January 20, 2017): 1–2. http://dx.doi.org/10.17229/jdit.2017-0120-025.

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Harfi, Thura T., Michael Wesley Milks, David A. Orsinelli, Subha V. Raman, William T. Abraham, and Rami Kahwash. "Imaging Device Therapy." Heart Failure Clinics 15, no. 2 (April 2019): 305–20. http://dx.doi.org/10.1016/j.hfc.2018.12.011.

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Mansi, Luigi, Sean Kitson, Vincenzo Cuccurullo, and Andrea Ciarmiello. "Basic Premises to Molecular Imaging and Radionuclide Therapy – Part 1." Journal of Diagnostic Imaging in Therapy 1, no. 1 (November 25, 2014): 137–56. http://dx.doi.org/10.17229/jdit.2014-1125-010.

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Moriarty, Thomas M., Ron Kikinis, Ferenc A. Jolesz, Peter McL Black, and Eben Alexander. "Magnetic Resonance Imaging Therapy: Intraoperative MR Imaging." Neurosurgery Clinics of North America 7, no. 2 (April 1996): 323–31. http://dx.doi.org/10.1016/s1042-3680(18)30396-6.

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Scott, Andrew M., and Steven M. Larson. "TUMOR IMAGING AND THERAPY." Radiologic Clinics of North America 31, no. 4 (July 1993): 859–79. http://dx.doi.org/10.1016/s0033-8389(22)02645-8.

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Altai, Mohamed, Rosemery Membreno, Brendon Cook, Vladimir Tolmachev, and Brian M. Zeglis. "Pretargeted Imaging and Therapy." Journal of Nuclear Medicine 58, no. 10 (July 7, 2017): 1553–59. http://dx.doi.org/10.2967/jnumed.117.189944.

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Chandrashekhar, Y. "Imaging for Improving Therapy." JACC: Cardiovascular Imaging 6, no. 5 (May 2013): 582–86. http://dx.doi.org/10.1016/j.jcmg.2013.04.002.

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Abraham, Theodore, David Kass, Giovanni Tonti, Gery F. Tomassoni, William T. Abraham, Jeroen J. Bax, and Thomas H. Marwick. "Imaging Cardiac Resynchronization Therapy." JACC: Cardiovascular Imaging 2, no. 4 (April 2009): 486–97. http://dx.doi.org/10.1016/j.jcmg.2009.01.005.

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Dissertations / Theses on the topic "Imaging and Therapy"

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Heard, Sarah. "Bremsstrahlung Imaging for Radionuclide Therapy." Thesis, Institute of Cancer Research (University Of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487454.

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Beta-emitting radioisotopes such as 90y & 32p do not emit gamma radiation, and so their detection during radionuclide therapies relies on the bremsstrahlung photons released when electrons interact in tissue. The aim of this project was to optimise acquisition parameters (energy window and collimator) for imaging the complex spectra, which are continuous up to relatively high energies, and are of low intensity. Experimental work and theoretical explorations used a combination of list-mode acquisition on an ADAC Forte gamma camera and EGSnrc Monte Carlo simulations. Initially, the camera's energy linearity was investigated and appropriate settings selected for the wide energy range. Photon kernels were developed to approximate beta sources in simulations and were shown to increase speeds significantly. Acquisitions and simulations were then made of a range of phantoms containing 90y or 32p, with low, meditirn and high energy collimation. The data were binned into narrow energy windows, and the resulting images were assessed for vari a tion in qual ity with energy and collima tor, and with parameters such as depth and source-to-background ra tio. Medium energy collimation was found to offer the best compromise between sensitivity and spatial resolution. Image contrast was highest in energy windows near 100 keY, but signal-to-noise ratios (SNR) were highest at lower energies. Wide windows showed improved SNR without significant loss of spatial resolution or contrast. A setting of 60 to 170 keY was selected for the clinic, allowing for practical limits on the camera's window width. The Monte Carlo simulations demonstrated which photon interactions led to these results, for example at which energies septal penetration began to dominate, and how much of the blurring at low energies was due to characteristic x-rays produced in the collimator. The results of this work have been used for initial investigations into the optimisation of analogue imaging with gamma-emitting radioisotopes, for example 111In for 9OY.
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Morin, Kevin Wayne. "Scintigraphic imaging during gene therapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21605.pdf.

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Chen, Ian Ying-Li. "Molecular imaging of cardiac gene therapy /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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Shao, Ning. "Sensing, imaging and photodynamic therapy of cancer." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 73 p, 2007. http://proquest.umi.com/pqdweb?did=1400965061&sid=14&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Vernooij, Robbin Ralf. "New materials for cancer imaging and therapy." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/102985/.

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Metal-based photoactivated chemotherapy (PACT) involves a class of metal- based prodrugs, which may overcome the limitations and side effects of current metal-based chemotherapeutic agents on account of their novel mechanism(s) of action. In this thesis, a number of vibrational spectroscopic methods were developed and applied to study the mechanisms of metal-based PACT agents upon activation with light. A particularly promising PACT agent is the diazido Pt(IV) anticancer prodrug, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (1, py = pyrdine), in which photoinduced cleavage of ligands from platinum yields reactive species, which are likely implicated with the observed biological activity. However, monitoring the azido and hydroxido ligands, and the metal centre simultaneously remains challenging. Vibrational spectroscopy is a potentially powerful tool to study both metal and ligand vibrations without the requirement of labelling and is non- destructive at the same time. The essential first step was the screening of 1 by a range of vibrational spectroscopic methods, including Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), Raman and synchrotron radiation far-infrared (SR-FIR), aided by Density Functional Theory (DFT). This yielded an extensive vibrational fingerprint of 1 containing individual ligand (pyridine, hydroxide and azide) and platinum to ligand vibrations. The established methodologies provided the necessary basis for elucidating further photodecomposition and photoreaction pathways. Successive ATR-FTIR studies allowed for examinations of the photodecomposition of 1 complemented by transient electronic absorption and UV-Vis spectroscopy under 420 nm or 310 nm irradiation. Chemometric data evaluation using Principal Component Analysis (PCA) and Multi Curve Resolution Alternating Least Squares (MCR-ALS) on the steady state UV-Vis and ATR-FTIR spectra captured the formation of a Pt(II) intermediate, trans-[Pt(N3)(py)2(OH/H2O)] and a final product, trans-[Pt(py)2(OH/H2O)2], in which the trans pyridine scaffolds were retained. Upon irradiation, the rapid removal of the hydroxido stretching vibration was found to correlate to a shift in the anti-symmetric azido vibration, indicative of a possible second intermediate. Experimental evidence of subsequent azido dissociation from platinum suggests that at least one hydroxyl radical is formed in the reduction of Pt(IV) to Pt(II) under such conditions. Additionally, photoproducts formed upon irradiation of 1 in the presence of the DNA nucleotide 5’-guanosine monophosphate (5’- GMP) could be systematically studied using ATR-FTIR, mass spectrometry and DFT calculations. Underpinning methodologies were subsequently applied to study a series of photoactivatable ruthenium-based CO releasing complexes of the formula [RuLCl2(CO)2] (L = 2,2’-bipyridine with 4’ methyl and/or carboxyl substituents). A three-step mechanism involving the sequential formation of [RuL(CO)(CH3CN)Cl2], [RuL(CH3CN)2Cl2] and [RuL(CH3CN)3Cl]+ was deduced upon 350 nm irradiation in acetonitrile. Rapid removal of the first CO ligand (k1 ≫ 3 min−1 ) and a modest rate for the second CO ligand (k2 = 0.099 – 0.17 min−1 ) was observed, with slowest rates found for the electron-withdrawing carboxyl substituents. Aqueous media considerably slowed down the photodecarbonylation (k1 = 0.46 – 1.3 min−1 and k2 = 0.026 – 0.035 min−1 ) and the carboxyl groups were shown to have a less pronounced effect on the rate constants, revealing the possible implications for the design of such candidates intended for clinical application. State-of-the-art synchrotron based infrared spectroscopy was utilised with continued focus on the mechanism of action of 1. ATR-FTIR and synchrotron radiation far-infrared were combined (SR-ATR-FIR) to enable the rapid screening of samples, exposing changes to the metal to ligand vibrations of 1. Additionally, in situ irradiation using liquid transmission SR-FIR revealed the removal of in the platinum to oxygen (hydroxide) and platinum to nitrogen (azide) vibrations simultaneously. Moreover, a mid-infrared live single cell study of 1 on acute myeloid leukaemia cells (K562) by Synchrotron Radiation Infrared Microspectroscopy revealed significant changes to DNA base stacking and lipid vibrations after only four hours of low dose irradiation at 350 nm (2.58 J cm- 2 ). Lastly, the low wavelength excitation of the earlier described photoactivatable metal-based anticancer prodrug candidates was considered, which commonly hamper their clinical feasibility. A range of lanthanide-doped upconverting nanoparticles (UCNPs) were synthesised, allowing for near-infrared light excitation and visible light emission as a potential platform for wavelength activation of PACT agents in a clinically-relevant window.
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McDannold, Nathan J. "MRI monitoring of high temperature ultrasound therapy /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2002.

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Thesis (Ph.D.)--Tufts University, 2002.
Adviser: David Weaver. Submitted to the Dept. of Physics. Includes bibliographical references (leaves 218-243). Access restricted to members of the Tufts University community. Also available via the World Wide Web;
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Holstensson, Maria. "Quantitative gamma camera imaging for radionuclide therapy dosimetry." Thesis, Institute of Cancer Research (University Of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533648.

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Gregory, Rebecca Anne. "Quantitative 124I pet imaging for radioiodine therapy disimetry." Thesis, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531335.

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Kharin, Alexander. "Group IV nanoparticles for cell imaging and therapy." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1032/document.

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La biomédecine et la biophotonique sont des champs de recherches en plein expansion qui grandissent à vive allure, constituant un secteur entier d'activités novatrices. Ce secteur, vraiment interdisciplinaire, comprend le développement de nouveaux nanomatériaux, de sources lumineuses et l'élaboration de nouveaux concepts, de dispositifs/équipements pour quantifier la conversion de photons et leurs interactions. L'importance décisive du diagnostic précoce et du traitement individuel des patients exige des thérapies soigneusement ciblées et la capacité de provoquer sélectivement la mort cellulaire des cellules malades. Malgré les progrès spectaculaires réalisés en utilisant les points quantiques ou des molécules biologiques organiques pour l'imagerie biologique et la libération ciblée de médicaments, plusieurs problèmes restent à résoudre : obtenir une sélectivité accrue pour une accumulation spécifique dans les tumeurs et une amélioration de l'efficacité des traitements. D'autres problèmes incluent la cytotoxicité et la génotoxicité, l'élimination lente et la stabilité chimique imparfaite. Des espérances nouvelles sont portées par de nouvelles classes de matériaux inorganiques comme les nanoparticules à base de silicium ou à base de carbone, qui pourraient faire preuves de caractéristiques de stabilité plus prometteuses tant pour le diagnostic médical que pour la thérapie. Pour cette raison, la découverte de nouveaux agents de marquage et de transport de médicaments représente un champ important de la recherche avec un potentiel de croissance renforcé
Biomedicine and biophotonics related businesses are currently growing at a breathtaking pace, thereby comprising one of the fastest growing sectors of innovative economy. This sector is truly interdisciplinary, including, very prominently, the development of novel nanomaterials, light sources, or novel device/equipment concepts to carry out photon conversion or interaction. The great importance of disease diagnosis at a very early stage and of the individual treatment of patients requires a carefully targeted therapy and the ability to induce cell death selectively in diseased cells. Despite the tremendous progress achieved by using quantum dots or organic molecules for bio-imaging and drug delivery, some problems still remain to be solved: increased selectivity for tumor accumulation, and enhancement of treatment efficiency. Other potential problems include cyto- and genotoxicity, slow clearance and low chemical stability. Significant expectations are now related to novel classes of inorganic materials, such as silicon-based or carbon-based nanoparticles, which could exhibit more stable and promising characteristics for both medical diagnostics and therapy. For this reason, new labeling and drug delivery agents for medical application is an important field of research with strongly-growing potential.The 5 types of group IV nanoparticles had been synthesized by various methods. First one is the porous silicon, produced by the electrochemical etching of bulk silicon wafer. That well-known technique gives the material with remarkably bright photoluminescence and the complicated porous structure. The porous silicon particles are the agglomerates of the small silicon crystallites with 3nm size. Second type is 20 nm crystalline silicon particles, produced by the laser ablation of the bulk silicon in water. Those particles have lack of PL under UV excitation, but they can luminesce under 2photon excitation conditions. 3rd type of the particles is the 8 nm nanodiamonds
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Foy, Susan Patricia. "Multifunctional Magnetic Nanoparticles for Cancer Imaging and Therapy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1319836040.

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Books on the topic "Imaging and Therapy"

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Hamblin, Michael R. Imaging in Photodynamic Therapy. Boca Raton: Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/b21922.

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Hamblin, Michael R., and Yingying Huang, eds. Imaging in Photodynamic Therapy. Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: CRC Press, 2017. http://dx.doi.org/10.1201/9781315278179.

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American Association of Physicists in Medicine. Summer School. Imaging in radiation therapy. Secaucus, N.J: Springer Verlag, 1998.

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Nishino, Mizuki, ed. Therapy Response Imaging in Oncology. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-31171-1.

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Aglietta, Massimo, and Daniele Regge, eds. Imaging Tumor Response to Therapy. Milano: Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2613-1.

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Vallabhajosula, Shankar. Molecular Imaging and Targeted Therapy. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23205-3.

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Shields, Anthony F., and Pat Price, eds. In Vivo Imaging of Cancer Therapy. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-341-7.

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Jolesz, Ferenc A., ed. Intraoperative Imaging and Image-Guided Therapy. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-7657-3.

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1920-, Robertson James S., and Held Kathryn D, eds. Nuclear medicine therapy. New York: Thieme Medical Publishers, 1987.

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Srivastava, Suresh C., ed. Radiolabeled Monoclonal Antibodies for Imaging and Therapy. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5538-0.

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Book chapters on the topic "Imaging and Therapy"

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Adelsmayr, Gabriel, Gisela Sponner, and Michael Fuchsjäger. "Minimal Invasive Therapy." In Breast Imaging, 359–73. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94918-1_17.

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Liang, Yajie, and Jeff W. M. Bulte. "IMAGING CELL THERAPY." In Drug Delivery Applications of Noninvasive Imaging, 223–51. Hoboken, NJ: John Wiley & Sons, Inc, 2013. http://dx.doi.org/10.1002/9781118356845.ch10.

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Farshey, Reza. "Imaging technologies." In Current Therapy in Endodontics, 15–26. Hoboken, New Jersey: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119067757.ch2.

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Lång, Kristina, and Miri Sklair Levy. "Breast Imaging." In Breast Cancer Radiation Therapy, 49–59. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-91170-6_9.

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Bambace, Santa, Giuseppe Bove, Stefania Carbone, Samantha Cornacchia, Angelo Errico, Maria Cristina Frassanito, Giovanna Lovino, Anna Maria Grazia Pastore, and Girolamo Spagnoletti. "Radiation Therapy." In Imaging Gliomas After Treatment, 23–28. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-31210-7_3.

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Testa, Laura, and Renata Colombo Bonadio. "Adjuvant Therapy." In Modern Breast Cancer Imaging, 435–38. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-84546-9_19.

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de Camargo Moraes, Paula. "Radiation Therapy." In Modern Breast Cancer Imaging, 415–33. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-84546-9_18.

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Bambace, Santa, Stefania Carbone, and Tommaso Scarabino. "Radiation Therapy." In Imaging Gliomas After Treatment, 17–19. Milano: Springer Milan, 2012. http://dx.doi.org/10.1007/978-88-470-2370-3_3.

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Weis, Serge, Michael Sonnberger, Andreas Dunzinger, Eva Voglmayr, Martin Aichholzer, Raimund Kleiser, and Peter Strasser. "Therapy-Induced Lesions." In Imaging Brain Diseases, 2107–18. Vienna: Springer Vienna, 2019. http://dx.doi.org/10.1007/978-3-7091-1544-2_82.

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DeSousa, Keith G., and Albert S. Favate. "Medical Therapy of Acute Stroke." In Neurovascular Imaging, 413–23. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-9029-6_40.

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Conference papers on the topic "Imaging and Therapy"

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Dupuy, Clément, Samuel Powell, Terence S. Leung, and François Ramaz. "Acousto-optic imaging and reconstruction in highly scattering media: towards quantitative imaging." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.jw3a.9.

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Stepp, Herbert, Ronald Sroka, and Walter Stummer. "Intra-operative Brain Tumor Imaging." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.jm2a.1.

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Zakariya, Abdullah J. "Integrated Dual Wavelength LED for Irradiation Blood Therapy." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.jtu3a.42.

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Wang, Jing, and Jun Liu. "PEI-Folic acid modified carbon nanodots for cancer cells targeted delivery and two-photon excitation imaging." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.jm3a.51.

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Rossi, Vincent M., and Steven L. Jacques. "Assessing mitochondrial swelling due to apoptosis via optical scatter imaging and a digital Fourier holographic microscope." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.ptu3a.3.

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Levenson, Richard, Zachary Harmany, and Farzad Fereidouni. "Histopathology Methods, Assays and their Applications." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.cth1a.1.

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Guo, Qiang, Hongwei Chen, Yuxi Wang, Minghua Chen, Sigang Yang, and Shizhong Xie. "High-throughput compressed sensing based imaging flow cytometry." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.cth1a.2.

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Gemmell, N. R., A. McCarthy, M. M. Kim, I. Veilluex, T. C. Zhu, G. S. Buller, B. C. Wilson, and R. H. Hadfield. "A Compact Fiber Optic Based Singlet Oxygen Luminescence Sensor." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.cth1a.3.

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Glaser, Adam K., and Jonathan T. C. Liu. "A light sheet microscopy system for rapid, volumetric imaging and pathology of large tissue specimens." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.cth1a.4.

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Elfer, Katherine, Andrew Sholl, and J. Quincy Brown. "Evaluation of Lung and Prostate Biospecimens at the Point-of-Acquisition with a Dual-Color Fluorescent H&E Analog." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.cth1a.5.

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Reports on the topic "Imaging and Therapy"

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Cai, Weibo. Molecular Imaging and Therapy of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2015. http://dx.doi.org/10.21236/ada630120.

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Su, Min-Ying. MR Imaging and Gene Therapy of Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 2001. http://dx.doi.org/10.21236/ada398125.

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Panchapakesan, Balaji. Integrated Molecular Imaging and Therapy for Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, August 2008. http://dx.doi.org/10.21236/ada494146.

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Su, Min-Ying. MR Imaging and Gene Therapy of Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 1999. http://dx.doi.org/10.21236/ada382893.

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Panchapakesan, Balaji. Integrated Molecular Imaging and Therapy for Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, August 2007. http://dx.doi.org/10.21236/ada474716.

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Pan, Dongfeng. Nuclear Imaging for Assessment of Prostate Cancer Gene Therapy. Fort Belvoir, VA: Defense Technical Information Center, April 2005. http://dx.doi.org/10.21236/ada442718.

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Sharkey, Robert M. Bispecific Antibody Pretargeting for Improving Cancer Imaging and Therapy. Office of Scientific and Technical Information (OSTI), February 2005. http://dx.doi.org/10.2172/898305.

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Pan, Dongfeng. Nuclear Imaging for Assessment of Prostate Cancer Gene Therapy. Fort Belvoir, VA: Defense Technical Information Center, April 2003. http://dx.doi.org/10.21236/ada415953.

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Pan, Dongfeng. Nuclear Imaging for Assessment of Prostate Cancer Gene Therapy. Fort Belvoir, VA: Defense Technical Information Center, April 2004. http://dx.doi.org/10.21236/ada425757.

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Lapi, Suzanne E. Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy. Office of Scientific and Technical Information (OSTI), November 2019. http://dx.doi.org/10.2172/1575920.

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