Academic literature on the topic 'Imagerie à haut contenu'
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Journal articles on the topic "Imagerie à haut contenu"
Roy, C. "4320 Imagerie haute resolution du contenu scrotal." Journal de Radiologie 87, no. 10 (October 2006): 1183. http://dx.doi.org/10.1016/s0221-0363(06)86650-3.
Full textIfergan, J., R. Pommier, M. C. Brion, L. Glas, L. Rocher, and M. F. Bellin. "Imagerie des infections du haut appareil urinaire." Journal de Radiologie Diagnostique et Interventionnelle 93, no. 6 (June 2012): 539–50. http://dx.doi.org/10.1016/j.jradio.2012.02.008.
Full textShabajee, Preety, Albane Gaudeau, Céline Legros, Thierry Dorval, and Jean-Philippe Stéphan. "Du criblage à haut contenu à la déconvolution de cibles." médecine/sciences 37, no. 3 (March 2021): 249–57. http://dx.doi.org/10.1051/medsci/2021013.
Full textBrunelle, Cédric. "La concentration des fonctions à haut contenu en savoir dans le secteur de la production des biens : quel avenir pour les régions non métropolitaines du Québec ?" Cahiers de géographie du Québec 56, no. 158 (February 28, 2013): 313–42. http://dx.doi.org/10.7202/1014549ar.
Full textChevalier, Nicole. "Imagerie et répétition mentale : recherches et avenues pour le sport de haut niveau." STAPS 8, no. 16 (1987): 33–39. http://dx.doi.org/10.3406/staps.1987.1496.
Full textBrodin, Priscille, Elaine DelNery, and Emmanuelle Soleilhac. "Criblage phénotypique à haut contenu pour la chémobiologie et ses enjeux." médecine/sciences 31, no. 2 (February 2015): 187–96. http://dx.doi.org/10.1051/medsci/20153102016.
Full textZuliani, Jean-Marc. "Effets de proximité et développement métropolitain des services de haut niveau : le cas de Toulouse." Sud-Ouest européen 2, no. 1 (1998): 33–45. http://dx.doi.org/10.3406/rgpso.1998.2683.
Full textKleinschmidt, Andreas. "Retrouver le contenu de la conscience dans le « bruit » de la neuro-imagerie." médecine/sciences 27, no. 2 (February 2011): 199–203. http://dx.doi.org/10.1051/medsci/2011272199.
Full textTonnelet, R., M. Labrousse, J. M. Escanye, B. Chen, A. Sewonu, O. Morel, J. Felblinger, M. Lhuaire, and M. Braun. "Micro-imagerie par résonance magnétique à haut champ : nouvel outil de l’anatomiste." Morphologie 97, no. 318-319 (October 2013): 96–97. http://dx.doi.org/10.1016/j.morpho.2013.09.089.
Full textLe Boeuf, Romain. "La déclaration de cessez-le-feu entre l’Arménie et l’Azerbaïdjan : un nouvel épisode de la lutte pour le Haut-Karabakh." Annuaire français de droit international 66, no. 1 (2020): 271–91. http://dx.doi.org/10.3406/afdi.2020.5459.
Full textDissertations / Theses on the topic "Imagerie à haut contenu"
Mau, Adrien. "Développements pour l'imagerie quantitative et à haut contenu en microscopie de fluorescence classique et super-résolue." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASP016.
Full textFluorescence and Single Molecule Localization Microscopy (SMLM) allows for thespecific labeling and imaging of biological samples, and are an essential tool for biologists.However, images are generally non-quantitative and limited in feld of view, as well as in imagingtimes. These limits are fundamentally linked to the illumination scheme, which should be optimized both in term of uniformity, but also in control of the irradiance. We propose a novelillumination scheme named ASTER, which allow for a versatile and uniform illumination and is compatible with classical optical sectioning schemes. We first apply ASTER to fluorescence microscopy and particularly the imaging of live dynamic samples. Then we show the ability toobtain uniform resolution in SMLM, as well as the potential of ASTER's versatility. One mayreduce the uorescent background, image wide200 x 200 µm² fields, or realize a SMLM image under a minute. Finally, we present theimplementation of a multicolor SMLM experiment, allowing for the simultaneous imaging ofdifferent structures with cross-talks around 2%.This method is quanti ed and optimized, andthen applied to two and three color imaging, aswell as 3D imaging. Different perspectives for ASTER and multicolor imaging are then proposed
German, Yolla. "L'imagerie cellulaire à haut débit révèle le contrôle de la synapse immunologique par le cytosquelette d'actine." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30015.
Full textCytotoxic lymphocytes rely on actin cytoskeleton remodeling to achieve their function. In particular cytotoxic T lymphocytes and NK cells assemble the immunological synapse (IS), a complex actin-rich structure that allows the interaction with target cells, such as infected cells or tumor cells, and permits the polarized delivery of lytic granules. Although actin cytoskeleton remodeling is known to be a driving force of IS assembly and dynamics, our understanding of the molecular control of actin remodeling sustaining IS dynamics remains fragmented. This PhD project consisted in developing a high-content imaging approach to unbiasedly define the metrics of IS from human T and NK lymphocytes and to characterize the requirements for actin cytoskeleton integrity in organizing the IS architecture.For that purpose, the stimulation and staining of cell lines and primary cells in multiwell plates and acquisition of a unique set of >100.000 confocal images with a fully automatized high-content imager was optimized. The images were analyzed with two complementary CellProfiler analytical pipelines to characterize the morphological features associated with different treatments and disease status. We first extracted 16 morphological features pertaining to F-actin, LFA-1 or lytic molecules based on prior knowledge of IS assembly, and included features pertaining to the nucleus. We show that IS assembly in Jurkat and NK-92 cells is characterized by increased F-actin intensity and cell area. For Jurkat cells, we report an increase in LFA-1 intensity and surface area, and for NK-92 cells an increase in lytic granule detection at the IS plane. We then treated NK-92 cells with seven drugs known to affect different aspects of actin dynamics and investigated the associated effects on IS features. We report concentration dependent effects, not only on F-actin intensity, as expected, but also on lytic granule polarization. Furthermore, using a high-resolution morphological profiling based on >300 features, we show that each drug inflicts distinct alterations of IS morphology. In a next step, we applied our experimental pipeline to primary NK cells isolated from the blood of healthy donors. Distinct morphological features were characterized among the NK cells from different donors, highlighting the sensitivity of our approach, but also revealing an unsuspected variability of immune cell morphologies among donors. We then further applied our approach to primary CD8+ T cells from patients with a rare immunodeficiency due to mutations in the gene encoding the actin regulator ARPC1B. ARPC1B deficiency results in decreased F-actin intensity, as well as in lytic granule polarization. This prompted us to assess the ability of these cells to kill target cells, which was markedly reduced. These results illustrate how the systematic analysis of the IS might be used to assist the exploration of fonctional defects of lymphocyte populations in pathological settings. In conclusion, our study reveals that although assembly of the IS can be characterized by a few features such as F-actin intensity and cell spreading, capturing fine alterations of that complex structure that arise from cytoskeleton dysregulation requires a high-content analysis. The pipeline we developed through this project holds promises for the morphological profiling of lymphocytes from primary immunodeficiency patients whose genetic defect has not yet been identified. Moreover, the discriminative power of our high-content approach could be exploited to characterize the response of lymphocytes to various stimuli and to monitor lymphocyte activation in multiple immune-related pathologies and treatment settings
Schoenauer, Sebag Alice. "Développement de méthodes pour les données de cribles temporels à haut contenu et haut débit : versatilité et analyses comparatives." Thesis, Paris, ENMP, 2015. http://www.theses.fr/2015ENMP0035/document.
Full textBiological screens test large sets of experimental conditions with respect to their specific biological effect on living systems. Technical and computational progresses have made it possible to perform such screens at a large scale - up to hundreds of thousands of experiments. Live cell imaging is an excellent tool to study in detail the consequences of chemical perturbation on a given biological process. However, the analysis of live cell screens demands the combination of robust computer vision methods, efficient statistical methods for the detection of significant effects and robust procedures for quality control. This thesis addresses these challenges by developing analytical methods for the analysis of High Throughput time-lapse microscopy screening data. The developed frameworks are applied to publicly available HCS data, demonstrating their applicability and the benefits of HCS data remining. The first multivariate workflow for the study of single cell motility in such large-scale data is detailed in Chapter 2. Chapter 3 presents this workflow application to previously published data, and the development of a new distance for drug target inference by in silico comparisons of parallel siRNA and drug screens. Finally, chapter 4 presents a complete methodological pipeline for performing HT time-lapse screens in Environmental Toxicology
Reboud, Julien. "Mise au point d'un format innovant de puces à cellules pour l'analyse phénotypique à haut-contenu." Université Joseph Fourier (Grenoble), 2006. http://www.theses.fr/2006GRE10047.
Full textNowadays biology research is faced with a considerable amount of genomic data which has to be functionally characterised in order to bring new concepts, which will lead to new therapies. These studies approach molecular-based mechanisms, and need high-throughput and parallel data management. The multidisciplinary work presented here has allowed the development of a miniaturised technology of cell culture in liquid drops, matrixed on a plane solid substrate, to test the action of molecules or conditions on the cells behaviour. After the macroscopic demonstration of nucleic acid molecule transfection in living cells on such a device, we have developed a fabrication protocol for a miniaturised support, able to maintain 100 nano-drops per cm², based on differential surface tensions. A picoliter dispensing robot was integrated to make the cell culture drops automatically. The cells' behaviour in the drops is analysed by high-content fluorescence microscopy after fixation. Each cell of each drop is characterised by tenths of parameters individually. This new analytical approach, which has triggered the development of new bio-statistical tools, has been applied to a multipartner project of siRNA screening, aimed at studying the impact of genes on glioblastoma cells chemoresistance. We have also shown the use of mass spectrometry as a multiparametric phenotyping method. This cell-on-chip technology seems particularly well suited for the study of the precise behaviour of cells among a population at high-throughput. It will be the base of new lab-on-chip technologies
Beaulieu, Mathilde. "Imagerie optique à très haut contraste : une approche instrumentale optimale." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4040/document.
Full textThis thesis aims to optimize high-contrast imaging performance in visible and near infrared for exoplanet detection. The main study focuses on high-contrast at small separation, to image exoplanets in their habitable zone. This direct detection is achievable with the next Extremely Large Telescopes and with the development of coronagraph providing high performance at small separation. The approach adopted for this study creates a high-contrast region (a dark hole) with the combination of coronagraphy and wavefront shaping (wavefront control of both phase and amplitude with 2 deformable mirrors) but is limited by the Fresnel propagation of phase aberrations. The goal of this work is to define the wavefront shaping limitation in optical configuration (deformable mirrors location, component optical quality, beam diameter). A semi-analytic approach followed by a Monte-Carlo analysis of numerical end-to-end simulations is studied, resulting in the definition of the optimal configuration. Results are then applied to SPEED, a test bench to optimize and test high-contrast imaging at small separation with a segmented pupil. Another aspect of this thesis is a contribution to a stability study to treat the temporal stability as a crucial parameter in high-contrast imaging instrumentation, at the conception level. A preliminary work is initiated during the thesis to analyse the stability of the measuring instrument itself. A metrology tool and its thermal behaviour are thus studied. Finally, the last part of this thesis is a performance analysis of a new differential imaging technique, developed to improve high contrast with observations with different diaphragm sizes
Jai, Andaloussi Said. "Indexation de l'information médicale. Application à la recherche d'images et de vidéos par le contenu." Télécom Bretagne, 2010. http://www.theses.fr/2010TELB0150.
Full textThis PhD thesis addresses the use of multimedia medical databases for diagnostic decision and therapeutic follow-up. Our goal is to develop methods and a system to select in multimedia databases documents similar to a query document. These documents consist of text information, numeric images and sometimes videos. In the proposed diagnosis aid system, the database is queried with the patient file, or a part of it, as input. Our work therefore involves implementing methods related to Case-Based Reasoning (CBR), datamining, Content Based Image Retrieval (CBIR) and Content Based Video Retrieval (CBVR). These methods are evaluated on three multimodal medical databases. The first database consists of retinal images collected by the LaTIM laboratory for aided diabetic retinopathy follow-up. The second database is a public mammography database (Digital Database for Screening Mammography – DDSM –) collected by the University of South Florida. The third database consists of gastroenterology videos also collected by the LaTIM laboratory. This database is used to discover whether methods developed for fixed image retrieval can also be used for color video retrieval. The first part of this work focuses on the characterization of each image in the patient file. We continued the work started in our laboratory to characterize images globally in the compressed domain (vector quantization, DCT-JPEG, wavelets, adapted wavelets) for image retrieval. Compared to other compression methods, the wavelet decomposition led to a great improvement in terms of retrieval performance. However, the wavelet decomposition requires the specification of a kernel or basis function. To overcome this problem, we proposed an original image characterization method based on the BEMD (Bidimensionnal Empirical Mode Decomposition). It allows decomposing an image into several BIMFs (Bidimensionnal Intrinsic Mode Functions) that provide access to frequency information of the image content. An originality of the method comes from the self-adaptivity of BEMD: it does not require the specification of a basic function. Once images are characterized, a similarity search is performed by computing the distance between the signature of the query image and the signature of each image in the database, given a metric. This process leads to the selection of similar images, without semantic meaning. An optimization process, based on genetic algorithms, is used to adapt the distance metric and thus improve retrieval performance. Then, the problem of content based video retrieval is addressed. A method to generate video signatures is presented. This method relies on key video frames extracted by movement analysis. The distance between video signatures is computed using a Principal Component Analysis (PCA) based technique. Finally, the proposed methods are integrated into the framework of patient file retrieval (each patient file consisting of several images and textual information). Three methods developed during a PhD thesis recently defended in our laboratory are used for patient file retrieval: the first approach is based on decision trees and their extensions, the second on Bayesian networks and the third on the Dezert-Smarandache theory (DSmT).
Benoit, Landry. "Imagerie multimodalité appliquée au phénotypage haut-débit des semences et plantules." Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0084.
Full textAlong this work, we have used the potentiality of different modalities of imagery that we apply to the plant domain so as to contribute to the high-throughput phenotyping of seeds and seedlings. We have mainly committed ourselves to the search for answers to two specific and important problematic in this domain. We begin by showing the applicability of visible imaging using an inactinic light and passive thermographic imaging to image the development of seeds and seedlings, a biological phenomenon usually occurring in soil and darkness. We present our contributions to this type of imaging through our contributions to the conception and the realization of a vision system using visible inactinic imaging, whose finality is the realization of individualized automated measurement on the seeds, the seedlings and the organs of the seedlings. This system handle seedling crossing, through the original use of anisotropic diffusion, which allowed us to multiply, without information loss, the output by ten. Furthermore, this system carries out the separation of the organs by means of a generic criterion based on gravitropism. The validation of the image processing algorithms of the vision system use original ways (numerical simulation and test of the influence of the uncertainty through agronomic simulation). Thermographic imaging, which captures the passive heat radiation of objects, allows us to visualize and to measure seeds and seedlings in the darkness. It also allows realizing the segmentation and the tracking of the organs of seedlings. This imaging technology also allowed us to demonstrate the feasibility of a non-destructive determination of sugar quantity in organs of beet seedlings. We then propose a generic methodology that allows the conception of spectrally optimized low-cost sensors, according to determined application tasks. This methodology uses information theory, to extract from, relatively expensive, hyperspectral imaging, the information needed for the conception of the dedicated low-cost sensors. The interest of this methodology for plant phenotyping has been shown and justifies its transfer to the world of research in plant biology
Stout, Jacques. "Spectroscopie et Imagerie RMN multi-noyaux à très haut champ magnétique." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS312/document.
Full textBipolar disorder is a chronic affective disorder affecting 1 to 3% of the adult population worldwide and has a high level of comorbidity with suicide rates, substance abuse and other harmful conditions. The disorder has possible ties to schizophrenia and has been observed to have a strong genetic component. The exact biological underpinnings have not been firmly established, however abnormalities in limbic subcortical and prefrontal areas have been observed.Ever since its discovery more than half a century ago, a daily intake of Lithium salts has arguably become the most reliable treatment of the disorder, despite us possessing little to no understanding of its biochemical action. In order to shed some light on the effect of Lithium in the brain, we have developed Lithium-7 MR imaging at 7 and 17 Tesla in order to assess its cerebral concentration and distribution. Specifically, I worked on developing and validating several acquisition, reconstruction and quantification methods dedicated to 7Li MRI and MRS. Those methods were first applied to study ex vivo the cerebral distribution of lithium in rats. These rats were pretreated for 28 days with Li2CO3, sacrificed and their head fixated with PFA. Using a home-made 1H/7Li radiofrequency surface coil and a 7Li Turbo Spin echo acquisition and a modified phantom replacement method for quantification, we were able to measure Li concentration maps. Regional Li concentration values were then compared with those obtained with mass spectrometry.After this preclinical proof-of-concept study, an in vivo 7Li MRI protocol was designed to map the cerebral Li concentration in euthymic bipolar subjects at 7T. These individuals all followed a regular lithium treatment. For this study, we chose to use an ultra-short echo-time Steady State Free Precession sequence with non-Cartesian k-space sampling. A quantification and analysis pipeline similar to the one used for our preclinical study was applied for this study, with the addition of a correction step for B0 inhomogeneities. After conducting a statistical analysis at the cohort level, it was assessed that the left hippocampus, a major part of the limbic system that has been associated with BD on multiple occasions, exhibited systematically a high level of lithium. Finally, I developed a quantification method accounting for the different relaxation times of 7Li in the CSF and in the brain parenchyma. This method was applied to image lithium at 7T in a subset of bipolar patients reducing drastically the differences initially observed between the SSFP and bSSFP sequences
Po, Chrystelle. "Etude par IRM à haut champ de l'ischémie cérébrale transitoire chez le rat nouveau né." Thesis, Evry-Val d'Essonne, 2009. http://www.theses.fr/2009EVRY0002.
Full textThe aim of this study was to characterize by in vivo MRI and MRS the short term and middle term developments of cerebral injuries following an experimental transient focal ischemia in the newborn rat (P7). The results show the efficiency of MRI to monitor the short term extent of the injured areas during ischemia and reperfusion and to predict the extent of the middle term extent of brain damage. The middle term monitoring has shown the development of a glial scar in the injured areas, by T2 weighted imaging, and the remodeling of the cerebral fiber networks, by Diffusion Tensor Imaging both in the glial scar and in ipsilateral adjacent areas. The monitoring of cerebral ischemia by these imaging methods will be thus a useful tool to evaluate the efficiency of therapeutic treatments directed toward these two processes
Hadam, Pawel. "Transports nouvelle génération dans les réseaux à très haut débit." Phd thesis, Grenoble INPG, 2005. http://tel.archives-ouvertes.fr/tel-00010643.
Full textBooks on the topic "Imagerie à haut contenu"
Reboud, Julien. Des micro-gouttes pour remplacer les souris?: Mise au point d?un format innovant de puces à cellules pour l?analyse phénotypique à haut-contenu. Omniscriptum, 2010.
Find full textBook chapters on the topic "Imagerie à haut contenu"
CALLOT, Virginie, and Alexandre VIGNAUD. "Imagerie à ultra-haut champ." In Les enjeux de l’IRM, 345–78. ISTE Group, 2023. http://dx.doi.org/10.51926/iste.9113.ch12.
Full textCottier, J. P., M. Ribeiro, S. Chapet, C. Destrieux, X. Cazals, M. A. Lauvin, Y. Pointreau, and A. Raimbault. "Imagerie post-thérapeutique des gliomes de haut grade." In Imagerie Post-Thérapeutique en Oncologie, 1–20. Elsevier, 2014. http://dx.doi.org/10.1016/b978-2-294-73840-1.00001-0.
Full textCoqueugniot, Hélène. "Paléo-imagerie par rayons X : une méthode d’exploration transdisciplinaire, de l’archéologie à la chirurgie Hélène." In Regards croisés: quand les sciences archéologiques rencontrent l'innovation, 139–56. Editions des archives contemporaines, 2017. http://dx.doi.org/10.17184/eac.3794.
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