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Journal articles on the topic 'IL32'

Author: Grafiati

Published: 14 March 2023

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1

Decombis, Salome, Antonin Papin, Celine Bellanger, et al. "The IL32/BAFF Axis Supports Prosurvival Dialog in the Lymphoma Ecosystem and Is Disrupted By NIK Inhibition." Blood 138, Supplement 1 (2021): 781. http://dx.doi.org/10.1182/blood-2021-144839.

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Abstract Background Aggressive B-cell lymphomas, such as Mantle cell lymphoma (MCL), are microenvironment-dependent tumors but, in contrast to tumoral intrinsic anomalies, complex interplays within their ecosystems are largely ignored. A better understanding of these dialogs could provide new perspectives integrating the key role of the microenvironment to increase treatment efficiency of this hard to cure B-cell malignancy. Methods To identify novel molecular regulations occurring in lymphoma protective ecosystems, we performed a transcriptomic analysis based on the comparison of publicly ava

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Lu, Huili, Wei Han, Abdulgabar Salama, and Anja Moldenhauer. "CXCL9 and IL32 Regulate Progenitor Expansion and Protect Hematopoietic Progenitor Cells From Chemotherapy." Blood 118, no. 21 (2011): 1316. http://dx.doi.org/10.1182/blood.v118.21.1316.1316.

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Abstract Abstract 1316 Background: We have reported that the cytokines CXCL9 and IL32 regulate murine bone marrow regeneration post chemotherapy, but the reasons for this effect and whether they work directly on progenitor cells remain unclear. Methods: Human CD34+ cells from cord blood were incubated with CXCL9 or IL32. Cell numbers were determined on a weekly basis, and one-week expanded cells were seeded on top of a confluent MS-5 stroma cell layer to determine the number of cobblestone-area forming and long-term culture initiating cells (LTC-IC). Apoptosis rates after incubation with CXCL9

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Kang, Ji Young, and Kyung Eun Kim. "Prognostic Value of Interleukin-32 Expression and Its Correlation with the Infiltration of Natural Killer Cells in Cutaneous Melanoma." Journal of Clinical Medicine 10, no. 20 (2021): 4691. http://dx.doi.org/10.3390/jcm10204691.

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Interleukin-32 (IL-32) is well known as a proinflammatory cytokine that is expressed in various immune cells and cancers. However, the clinical relevance of IL-32 expression in cutaneous melanoma has not been comprehensively studied. Here, we identified the prognostic value of IL32 expression using various systematic multiomic analyses. The IL32 expressions were significantly higher in cutaneous melanoma than in normal tissue, and Kaplan–Meier survival analysis showed a correlation between IL32 expression and good prognosis in cutaneous melanoma patients. In addition, we analyzed the correlati

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Baselli, Guido Alessandro, Paola Dongiovanni, Raffaela Rametta, et al. "Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker." Gut 69, no. 10 (2020): 1855–66. http://dx.doi.org/10.1136/gutjnl-2019-319226.

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ObjectiveEfforts to manage non-alcoholic fatty liver disease (NAFLD) are limited by the incomplete understanding of the pathogenic mechanisms and the absence of accurate non-invasive biomarkers. The aim of this study was to identify novel NAFLD therapeutic targets andbiomarkers by conducting liver transcriptomic analysis in patients stratified by the presence of the PNPLA3 I148M genetic risk variant.DesignWe sequenced the hepatic transcriptome of 125 obese individuals. ‘Severe NAFLD’ was defined as the presence of steatohepatitis, NAFLD activity score ≥4 or fibrosis stage ≥2. The circulating l

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Gautam, Anuradha, and Bhaswati Pandit. "IL32: The multifaceted and unconventional cytokine." Human Immunology 82, no. 9 (2021): 659–67. http://dx.doi.org/10.1016/j.humimm.2021.05.002.

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Logan, Jeongok G., Sijung Yun, Yongde Bao, Emily Farber, and Charles R. Farber. "RNA-sequencing analysis of differential gene expression associated with arterial stiffness." Vascular 28, no. 5 (2020): 655–63. http://dx.doi.org/10.1177/1708538120922650.

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Objectives Arterial stiffness is recognized as an important predictor of cardiovascular disease morbidity and mortality, independent of traditional cardiovascular disease risk factors. Given that arterial tissue is not easily accessible, most gene expression studies on arterial stiffness have been conducted on animals or on patients who have undergone by-pass surgeries. In order to obtain a deeper understanding of early changes of arterial stiffness, this study compared transcriptome profiles between healthy adults with higher and lower arterial stiffness. Methods The sample included 20 health

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Diakowska, Dorota, and Małgorzata Krzystek-Korpacka. "Local and Systemic Interleukin-32 in Esophageal, Gastric, and Colorectal Cancers: Clinical and Diagnostic Significance." Diagnostics 10, no. 10 (2020): 785. http://dx.doi.org/10.3390/diagnostics10100785.

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Little is known on clinical and diagnostic relevance of interleukin-32 in gastrointestinal tract (GIT) cancers. We determined its mRNA (n = 52) and protein (n = 63) expression in paired (tumor-normal) samples from esophageal squamous cell carcinoma (ESCC) and gastric (GC) and colorectal cancer (CRC) patients, with reference to cancer-associated genes, and quantified circulating interleukin-32 in 70 cancer patients and 28 controls. IL32 expression was significantly upregulated solely in ESCC, reflecting T stage in non-transformed tumor-adjacent tissue. Fold-change in IL32 and IL-32 was higher i

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Ramirez-Carracedo, Rafael, Laura Tesoro, Ignacio Hernandez, et al. "Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction." Biomolecules 10, no. 8 (2020): 1167. http://dx.doi.org/10.3390/biom10081167.

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Toll-like receptor 4 (TLR4) contributes to the pathogenesis of coronary ischemia/reperfusion (IR). To test whether the new TLR4 antagonist, ApTOLL, may prevent coronary IR damage, we administered 0.078 mg/kg ApTOLL or Placebo in pigs subjected to IR, analyzing the levels of cardiac troponins, matrix metalloproteinases, pro-, and anti-inflammatory cytokines, heart function, and tissue integrity over a period of 7 days after IR. Our results show that ApTOLL reduced cardiac troponin-1 24 h after administration, improving heart function, as detected by a significant recovery of the left ventricle

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Poma, Anello Marcello, Angelo Genoni, Francesco Broccolo, et al. "Immune Transcriptome of Cells Infected with Enterovirus Strains Obtained from Cases of Type 1 Diabetes." Microorganisms 8, no. 7 (2020): 1031. http://dx.doi.org/10.3390/microorganisms8071031.

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Enterovirus (EV) infection of insulin-producing pancreatic beta cells is associated with type 1 diabetes (T1D), but little is known about the mechanisms that lead the virus to cause a persistent infection and, possibly, to induce beta cell autoimmunity. A cell line susceptible to most enterovirus types was infected with EV isolates from cases of T1D and, for comparison, with a replication-competent strain of coxsackievirus B3. The transcription of immune-related genes and secretion of cytokines was evaluated in infected vs. uninfected cells. Acutely infected cells showed the preserved transcri

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Wang, Anna, Hongyan Guo, and Zaiqiu Long. "Integrative Analysis of Differently Expressed Genes Reveals a 17-Gene Prognosis Signature for Endometrial Carcinoma." BioMed Research International 2021 (July 14, 2021): 1–18. http://dx.doi.org/10.1155/2021/4804694.

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Endometrial carcinoma (EC) is the fifth widely occurring malignant neoplasm among women all over the world. However, there is still lacking efficacy indicators for EC’s prognosis. Here, we analyzed two databases including an RNA-sequencing-based TCGA dataset and a microarray-based GSE106191. After normalizing the raw data, we identified 114 common genes with upregulation and 308 common genes with downregulation in both the TCGA and GSE106191 databases. Bioinformatics analysis showed that the differently expressed genes in EC were related to the IL17 signaling pathway, PI3K-Akt signaling pathwa

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Molle, Céline, Tong Zhang, Laure Ysebrant de Lendonck, et al. "Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease." Journal of Experimental Medicine 210, no. 9 (2013): 1675–84. http://dx.doi.org/10.1084/jem.20120707.

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Interleukin (IL) 12 and IL23 are two related heterodimeric cytokines produced by antigen-presenting cells. The balance between these two cytokines plays a crucial role in the control of Th1/Th17 responses and autoimmune inflammation. Most studies focused on their transcriptional regulation. Herein, we explored the role of the adenine and uridine–rich element (ARE)–binding protein tristetraprolin (TTP) in influencing mRNA stability of IL12p35, IL12/23p40, and IL23p19 subunits. LPS-stimulated bone marrow–derived dendritic cells (BMDCs) from TTP−/− mice produced normal levels of IL12/23p40. Produ

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Lopes, M., F. Traina, J. K. Pereira, et al. "P-243 IL32 mRNA levels in peripheral blood CD3+ cells from MDS patients." Leukemia Research 37 (May 2013): S132—S133. http://dx.doi.org/10.1016/s0145-2126(13)70290-x.

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Liu, Jiapei, Kaibo Yang, Hua Jin, and Qifa Liu. "Transcriptomic Profiling of Circulating Extrafollicular Helper T-like Cells in Patients with Active Chronic Graft-Versus-Host Disease Reveals Distinct Apoptosis Resistance." Blood 138, Supplement 1 (2021): 4882. http://dx.doi.org/10.1182/blood-2021-148964.

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Abstract In our previous studies, we identiﬁed circulating extrafollicular helper T-like cells (CD44 hiCD62L loPSGL-1 loCD4 +, c-extrafollicular Th-like) in human peripheral blood. C-extrafollicular Th-like cells are associated with the development of cGVHD. However, the exact molecular mechanism of these cells in patient with active cGVHD is still unclear. We performed the whole transcriptome analysis of c-extrafollicular Th-like cells from patients with active cGVHD and without cGVHD to explore the molecular mechanism. We identified 4661 differentially expressed genes between two groups by R

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Smolnikova, M. V., A. A. Barilo, M. A. Malinchik, and S. V. Smirnova. "Search for genetic markers of predisposition to psoriasis and psoriatic arthritis." Medical Immunology (Russia) 22, no. 5 (2020): 925–32. http://dx.doi.org/10.15789/1563-0625-sfg-2050.

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Psoriasis (PS) and psoriatic arthritis (PsA) are interrelated diseases that occur in approximately 30% of patients and are characterized by the presence of a systemic inflammatory reaction that occurs as a result of a violation of the functional state of the immune system. With the advent of new technologies, several new pro-inflammatory cytokines, such as IL-23, IL-31, and IL-33, which play an important role in the pathogenesis of the psoriatic process, have been discovered and characterized. It was determined that single nucleotide polymorphisms (SNPs) in the promoter regions of the IL23, IL

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Powell, Nick, Eirini Pantazi, Polychronis Pavlidis, et al. "Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells." Gut 69, no. 3 (2019): 578–90. http://dx.doi.org/10.1136/gutjnl-2019-318483.

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ObjectiveThe functional role of interleukin-22 (IL22) in chronic inflammation is controversial, and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22 in chronic colitis and probed mechanisms of IL22-mediated regulation of colonic epithelial cells.DesignTo investigate the functional role of IL22 in chronic colitis and how it regulates colonic epithelial cells, we employed a three-dimentional mini-gut epithelial organoid system, in vivo disease models and transcriptomic datasets in human IBD.ResultsAs well as inducing tr

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He, Jianya, Wen Ye, Ni Kou, et al. "MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway." Journal of Cellular and Molecular Medicine 24, no. 1 (2020): 841–49. http://dx.doi.org/10.1111/jcmm.14794.

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Tokuyama, Michio, and Tomotaka Mabuchi. "New Treatment Addressing the Pathogenesis of Psoriasis." International Journal of Molecular Sciences 21, no. 20 (2020): 7488. http://dx.doi.org/10.3390/ijms21207488.

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Psoriasis is an immune cell-mediated inflammatory skin disease. The interleukin (IL)23/IL17 axis plays an important role in the development of psoriasis. The effectiveness of biologic treatments such as tumor necrosis factor (TNF)α inhibitors (infliximab, adalimumab, certolizumab pegol), IL23 inhibitors (ustekinumab, guselkumab, tildrakizumab, risankizumab), and IL17 inhibitors (secukinumab, ixekizumab, brodalumab) have verified these findings. Immune-related cells such as dendritic cells (DCs) and macrophages, in addition to Toll-like receptors and cytokines such as interferon (IFN)α, TNFα, I

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Koltsova, Ekaterina, Iuliia Peshkova, Amiran Dzutsev, et al. "Cytokine mediated control of microbiota and inflammation in atherosclerosis." Journal of Immunology 202, no. 1_Supplement (2019): 191.12. http://dx.doi.org/10.4049/jimmunol.202.supp.191.12.

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Abstract Atherosclerosis is lipid-driven, chronic inflammatory disease of the arterial wall. While commensal microbiota is involved in the distal regulation of systemic immune responses, how this distant connection influences the development of atherosclerosis and what are the underlying mechanisms remains largely unknown. In a mouse model of atherosclerosis, we found that disease was augmented when expression of the otherwise inflammatory cytokine IL23 was ablated. IL23 and its immediate downstream target IL22 restrict atherosclerosis by preventing outgrowth of microbiota, as inactivation of

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Sorrentino, Carlo, Stefania Livia Ciummo, Luigi D'Antonio, et al. "Interleukin-30 feeds breast cancer stem cells via CXCL10 and IL23 autocrine loops and shapes immune contexture and host outcome." Journal for ImmunoTherapy of Cancer 9, no. 10 (2021): e002966. http://dx.doi.org/10.1136/jitc-2021-002966.

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BackgroundBreast cancer (BC) progression to metastatic disease is the leading cause of death in women worldwide. Metastasis is driven by cancer stem cells (CSCs) and signals from their microenvironment. Interleukin (IL) 30 promotes BC progression, and its expression correlates with disease recurrence and mortality. Whether it acts by regulating BCSCs is unknown and could have significant therapeutic implications.MethodsHuman (h) and murine (m) BCSCs were tested for their production of and response to IL30 by using flow cytometry, confocal microscopy, proliferation and sphere-formation assays,

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Ohmatsu, Hanako, Daniel Humme, Nicholas Gulati, et al. "IL32 Is Progressively Expressed in Mycosis Fungoides Independent of Helper T-cell 2 and Helper T-cell 9 Polarization." Cancer Immunology Research 2, no. 9 (2014): 890–900. http://dx.doi.org/10.1158/2326-6066.cir-13-0199-t.

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Wen, Siyang, Yixuan Hou, Lixin Fu та ін. "Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3–p38 MAPK signalling". Cancer Letters 442 (лютий 2019): 320–32. http://dx.doi.org/10.1016/j.canlet.2018.10.015.

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Karim, Ahmad Faisal, Anthony R. Soltis, Nadia P. Ewing, Clifton L. Dalgard, Matthew D. Wilkerson, and Kathleen P. Pratt. "Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include up-Regulated Innate Immune Modulators." Blood 134, Supplement_1 (2019): 160. http://dx.doi.org/10.1182/blood-2019-124855.

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The formation of pathological anti-FVIII antibodies, referred to as "inhibitors", is the most serious complication of therapeutic FVIII infusions, affecting up to one third of severe Hemophilia A (HA) patients. Intensive FVIII therapy, i.e. "Immune Tolerance Induction" (ITI), enables ~2/3 of treated patients to achieve peripheral tolerance to FVIII. FVIII inhibitor formation is a classical T-cell dependent adaptive immune response. As such, it requires help from the innate immune system. However, the roles of innate immune cells and mechanisms of inhibitor development versus immune tolerance,

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Jihene, Ayari, Karrit Sarra, Haj Ammar Shourouk, et al. "Prognostic Value of Circulating Cytokines in Breast Cancer." Cancer Medicine Journal 3, no. 1 (2020): 1–9. http://dx.doi.org/10.46619/cmj.2020.3-1015.

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Objectives: The aim of this study was to measure circulating cytokines (IL17, IL6, IL22, IL23 and TNFα) and to evaluate their role as markers and in prognosis in Tunisian patients with breast cancer. Materials and methods: Our prospective study enrolled 60 untreated patients affected by breast cancer. We evaluated their levels of TNF-α and IL6 within solid-phase, two-site chemoluminescent enzyme immunemetric assay. Seric levels of IL17, IL22 and IL23 were measured by ELISA sandwich technique and results compared by chi-2 square. Results: Our population, all females, have a mean age of 48 years

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Rodolfo, M., C. Zilocchi, C. Melani, et al. "Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines." Journal of Immunology 157, no. 12 (1996): 5536–42. http://dx.doi.org/10.4049/jimmunol.157.12.5536.

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Abstract We have compared the therapeutic activity and characterized the antitumor response induced by IL-12 and IL-2 gene-transduced tumor cell vaccines. Mice bearing lung metastases of the BALB/c colon carcinoma C51 were treated with syngenic, histologically related, and antigenically cross-reacting irradiated IL-12 (C26/IL12) or IL-2 (C26/IL2) gene-transduced C26 tumor cells given s.c. Vaccination with C26/IL12 cells cured 40% of mice, while vaccination with C26/IL2 cells reduced the number of metastatic nodules without affecting survival. Despite this difference, similar antitumor CTL acti

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Yoshikawa, Yoshie, Yusuke Sasahara, Katsuyuki Takeuchi та ін. "Transcriptional Analysis of Hair Follicle-Derived Keratinocytes from Donors with Atopic Dermatitis Reveals Enhanced Induction of IL32 Gene by IFN-γ". International Journal of Molecular Sciences 14, № 2 (2013): 3215–27. http://dx.doi.org/10.3390/ijms14023215.

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Bhat, Shreyas, Nilesh Gardi, Sujata Hake, et al. "Impact of intra-tumoral IL17A and IL32 gene expression on T-cell responses and lymph node status in breast cancer patients." Journal of Cancer Research and Clinical Oncology 143, no. 9 (2017): 1745–56. http://dx.doi.org/10.1007/s00432-017-2431-5.

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Javvadi, L. R., V. P. B. Parachuru, T. J. Milne, G. J. Seymour, and Alison M. Rich. "Expression of IL33 and IL35 in oral lichen planus." Archives of Dermatological Research 310, no. 5 (2018): 431–41. http://dx.doi.org/10.1007/s00403-018-1829-5.

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Mortezavi, Mahta, and Christopher Ritchlin. "IL12/IL23 Inhibition in the Treatment of Psoriatic Arthritis." Current Treatment Options in Rheumatology 1, no. 2 (2015): 197–209. http://dx.doi.org/10.1007/s40674-015-0018-3.

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Gao, Chunji, Xiaohong Li, Jian Ma, et al. "Ex Vivo Expansion of Highly Purified Human NK Cells.." Blood 114, no. 22 (2009): 2157. http://dx.doi.org/10.1182/blood.v114.22.2157.2157.

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Abstract Abstract 2157 Poster Board II-134 Object To optimize the expansion of high purity NK cells from human peripheral blood and explore the changes in biological functions of NK cells after Ex vivo expansion. Methods NK cells were isolated from PBMNC by using miniMACS (Magnetic cell-selection) and NK Cell Isolation Kit II(Miltenyi Biotec, Germany), then they were cultured in SCEM (Stemline Hematopoietic Stem Cell Expansion Medium, Sigma) supplemented with 10% human AB serum and different combinations of interleukin (IL)-2 and/or IL-12, IL-15 for 15 days. Cultures were fed with fresh media

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Minaudo, Carla. "Vía JAK-STAT e inhibidores JAK." Dermatología Argentina 28, no. 2 (2022): 55–62. http://dx.doi.org/10.47196/da.v28i2.2324.

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La vía JAK-STAT (Janus Kinasas) es una cadena de traducción de señales intracelulares, que se activa a través de receptores de citoquinas I y II. Mediante esta vía, varias moléculas de importancia en dermatología ejercen sus efectos: IL2, IL4, IL7, IL5, IL6, IL9, IL12, IL13, IL15, IL21, IL23, INFa e INFb, entre otras. También es la señal intracelular de hormonas como la prolactina y la hormona de crecimiento. La inhibición de distintos componentes de esta vía es utilizada como terapéutica en enfermedades reumatológicas y un número cada vez mayor de patologías cutáneas. Los inhibidores JAK surg

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Rodriguez-Nieves, Jennifer, Ryan Tuck, and Kristina De Paris. "JAK/STAT Signaling of Natural Killer (NK) Cells Following Cytokine Stimulation." Journal of Immunology 198, no. 1_Supplement (2017): 124.20. http://dx.doi.org/10.4049/jimmunol.198.supp.124.20.

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Abstract Natural Killer (NK) cells are an important component of the innate immune system, capable of providing a fast and effective response against virally infected cells. NK cells are mainly characterized by their cytotoxic function and their ability to secrete cytokines. It has been shown that infant NK cells have decreased cytotoxicity and cytokine-secreting function, suggesting hyporesponsiveness of NK cells during the first year of life. Because NK cell activation is dependent on cytokine stimulation, we hypothesized that infant NK cells are hyporesponsive due to deficiencies in signali

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Saravia, Jordy, Dahui You, John DeVincenzo, and Stephania Cormier. "Group 2 innate lymphoid cells and IL-33 in infant respiratory syncytial virus infection (INC9P.442)." Journal of Immunology 192, no. 1_Supplement (2014): 188.1. http://dx.doi.org/10.4049/jimmunol.192.supp.188.1.

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Abstract Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections in infants with an estimated global impact of 64 million cases and 160,000 deaths each year. Severe RSV infections in infants are characterized by airway obstruction and Th2-biased immune responses, including recruitment of Th2 cells and eosinophils to the lung and elevated Th2 effector cytokines (IL4, IL5, IL13). Early elevations in IL13 following RSV infection of neonatal mice suggest a source other than Th2 cells. Group 2 innate lymphoid cells (ILC2s) are a recently identified populatio

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Miguel González, J. A., M. Sánchez Mayor, L. M. Cervera Seco, A. Gaite Reguero, P. Pavlidis, and U. Martínez Marigorta. "P900 Studying causality association of ustekinumab with cardiovascular disease outcomes using Mendelian randomization." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i1013. http://dx.doi.org/10.1093/ecco-jcc/jjac190.1030.

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Abstract Background The human antibody ustekinumab targets the common p40 subunit between both pro-inflammatory interleukin-12 (IL-12) and interleukin-23 (IL-23) that upregulate T cell differentiation towards T helper 1 (TH1) and T helper 17 (TH17) respectively. The blockade of the IL12-IL23 pathway has been shown to be an effective therapeutic option for Inflammatory Bowel Disease treatment, however a recent epidemiological study has reported a potential cardiovascular risk association for ustekinumab treatment in patients at high cardiovascular risk specifically1. We use mendelian randomizat

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Zaharescu, Anamaria, Sorina Mihaela Solomon, Mihaela Gabriela Luca, et al. "Cuantificarea moleculelor proinflamatorii (IL1-alfa, IL1-beta, IL2, IL 12, IFN-gama, TNF-alfa) in lichid crevicular si ser la pacientii cu leziuni endo-parodontale." Revista de Chimie 70, no. 6 (2019): 2252–55. http://dx.doi.org/10.37358/rc.19.6.7316.

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The present research proposes an assessment of the localized inflammatory burden but also at the systemic level by quantitating the pro-inflammatory molecules (IL1-a, IL1-b, IL2, IL12, IFN-g, TNF-a) with endo-periodontal lesions. The study was performed on a group of 146 subjects who, following clinical and radiological examinations, were divided into five groups: healthy endo-periodontal patients, patients with periodontitis, patients with moderate periodontitis, patients with severe periodontitis and patients presenting combined endo-periodontal lesions. IL1-a, IL1-b, IL2, IL12, IFN-g, TNF-a

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Long, Nguyen Phuoc, Seongoh Park, Nguyen Hoang Anh, et al. "Efficacy of Integrating a Novel 16-Gene Biomarker Panel and Intelligence Classifiers for Differential Diagnosis of Rheumatoid Arthritis and Osteoarthritis." Journal of Clinical Medicine 8, no. 1 (2019): 50. http://dx.doi.org/10.3390/jcm8010050.

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Introducing novel biomarkers for accurately detecting and differentiating rheumatoid arthritis (RA) and osteoarthritis (OA) using clinical samples is essential. In the current study, we searched for a novel data-driven gene signature of synovial tissues to differentiate RA from OA patients. Fifty-three RA, 41 OA, and 25 normal microarray-based transcriptome samples were utilized. The area under the curve random forests (RF) variable importance measurement was applied to seek the most influential differential genes between RA and OA. Five algorithms including RF, k-nearest neighbors (kNN), supp

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Friedlander, Philip Adam, Karl Wassman, Chrisann Kyi, William K. Oh, and Nina Bhardwaj. "Correlation of consistent blood-based gene expression with change in CTLA4 in two large independent clinical studies of patients with advanced melanoma treated with tremelimumab." Journal of Clinical Oncology 35, no. 7_suppl (2017): 6. http://dx.doi.org/10.1200/jco.2017.35.7_suppl.6.

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6 Background: We previously reported 16-gene pre- and 8-gene post-treatment response predictive gene signatures in whole blood that were trained in one cohort (N=210) of advanced melanoma patients treated with tremelimumab and validated in an independent test dataset (N=150) for both response and survival.(SITC 2016 Annual Meeting Poster Submission ID: 214348.) Methods: A correlation matrix was calculated for the change between pre- and post-treatment gene expression for all 169 genes in two independent clinical trials. The genes were ranked by their relationship with CTLA4. Comparison was mad

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HogenEsch, Harm, Srikanth Elesela, Syu-Jhe Chien, Kathleen Silva, Vicki Kennedy, and John P. Sundberg. "Role of group 2 innate lymphoid cells (ILC2) in SHARPIN-deficient mice." Journal of Immunology 198, no. 1_Supplement (2017): 221.15. http://dx.doi.org/10.4049/jimmunol.198.supp.221.15.

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Abstract SHARPIN is a component of the linear ubiquitination assembly complex and a key regulator of NFkB and integrin signaling. SHARPIN-deficient mice develop a phenotype known as chronic proliferative dermatitis (cpdm), characterized by progressive epidermal hyperplasia, apoptosis of keratinocytes, cutaneous and systemic eosinophilic inflammation, and hypoplasia of secondary lymphoid organs. We recently reported that the cutaneous inflammation in SHARPIN-deficient mice (Sharpincpdm) develops independently of B and T lymphocytes. We therefore sought to determine the role of innate lymphoid c

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Gang, Spencer S., Michelle L. Castelletto, Emily Yang, et al. "Chemosensory mechanisms of host seeking and infectivity in skin-penetrating nematodes." Proceedings of the National Academy of Sciences 117, no. 30 (2020): 17913–23. http://dx.doi.org/10.1073/pnas.1909710117.

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Approximately 800 million people worldwide are infected with one or more species of skin-penetrating nematodes. These parasites persist in the environment as developmentally arrested third-stage infective larvae (iL3s) that navigate toward host-emitted cues, contact host skin, and penetrate the skin. iL3s then reinitiate development inside the host in response to sensory cues, a process called activation. Here, we investigate how chemosensation drives host seeking and activation in skin-penetrating nematodes. We show that the olfactory preferences of iL3s are categorically different from those

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Dibra, Denada, Jeffry Cutrera, Xueqing Xia, and Shulin Li. "IL30—a novel anti-inflammatory cytokine candidate for preventing and treating inflammatory cytokine-induced liver injury in mice. (117.21)." Journal of Immunology 186, no. 1_Supplement (2011): 117.21. http://dx.doi.org/10.4049/jimmunol.186.supp.117.21.

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Abstract The liver is subjected to the lifetime attacks from chronic viral infection, uptake of the therapeutic drugs, life behavior (alcoholic), and environmental contaminants, results in chronic inflammation and fibrosis. It is urgent to discover effective therapeutic agents for preventing and treating livery injury and the ideal drug will be naturally occurring biological inhibitors. Here, we show that IL30 is a potent anti-inflammatory cytokine that inhibits liver toxicity. IL27, which contains IL30 subunit, does not have such a property. Interestingly, IL30 is induced by pro-inflammatory

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Sonder, Soren Ulrik, Matthew Plassmeyer та Oral Alpan. "Novel IL12Rβ1 mutation impairs Th1 response in heterozygote patient." Journal of Immunology 196, № 1_Supplement (2016): 196.5. http://dx.doi.org/10.4049/jimmunol.196.supp.196.5.

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Abstract The interleukin-12 Receptor beta-1 chain (12Rβ1) is a subunit in the functional IL12 and IL23 receptor that binds the IL12 p40 subunit of the IL12 and IL23 heterodimers. Patients that are homozygote for “lack of function” mutations in IL12Rβ1 are mainly characterized by defects in the Th1 response resulting in recurrent and severe disease caused by infections with poorly pathogenic mycobacteria and salmonellae. Family members that are heterozygote for these mutations are clinically unaffected. Here we describe a case of a 62 year old female patient that is heterozygote for the novel 1

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Borradaile, Nica M., and J. Geoffrey Pickering. "Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase." American Journal of Physiology-Cell Physiology 298, no. 1 (2010): C66—C74. http://dx.doi.org/10.1152/ajpcell.00357.2009.

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Polyploid endothelial cells are found in aged and atherosclerotic arteries. However, whether increased chromosome content has an impact on endothelial cell function is unknown. We show here that human aortic endothelial cells become tetraploid as they approach replicative senescence. Furthermore, accumulation of tetraploid endothelial cells was accelerated during growth in high glucose. Interestingly, induction of polyploidy was completely prevented by modest overexpression of the NAD+ regenerating enzyme, nicotinamide phosphoribosyltransferase (Nampt). To determine the impact of polyploidy on

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Sinitsky, M. Yu, A. V. Tsepokina, M. A. Asanov, Ya V. Kazachek, A. V. Evtushenko, and A. V. Ponasenko. "The expression level of cytokine genes in the cases of native heart valves in infectious endocarditis." Biomeditsinskaya Khimiya 66, no. 5 (2020): 406–10. http://dx.doi.org/10.18097/pbmc20206605406.

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The expression level of IL1B, IL6, IL8, IL10, IL12A, IL12B, IL18, IL23, IL33, CCL2, and IL1RL1 has been investigated using biopsies of native mitral, aortic, and tricuspid valves obtained during surgical correction of acquired defect from 25 patients with infectious endocarditis. Biopsies of native mitral and aortic valve cusps from 12 patients who underwent surgical correction of acquired heart disease of non-infectious etiology were used as control. We used quantitative PCR with fluorescent dye SYBR Green for determination of the cytokine gene expression level. This study revealed that genes

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Xia, Fei, Zhilong Yu, Aijun Deng, and Guohong Gao. "Identification of molecular subtyping system and four-gene prognostic signature with immune-related genes for uveal melanoma." Experimental Biology and Medicine 247, no. 3 (2021): 246–62. http://dx.doi.org/10.1177/15353702211053801.

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Immunotherapy is the most promising treatment for uveal melanoma patients with metastasis. Tumor microenvironment plays an essential role in tumor progression and greatly affects the efficacy of immunotherapy. This research constructed an immune-related subtyping system and discovered immune prognostic genes to further understand the immune mechanism in uveal melanoma. Immune-related genes were determined from literature. Gene expression profiles of uveal melanoma were clustered using consensus clustering based on immune-related genes. Subtypes were further divided by applying immune landscape

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Chen, Hualin, Wenjie Yang, Xiaoqiang Xue, Yingjie Li, Zhaoheng Jin, and Zhigang Ji. "Integrated Analysis Revealed an Inflammatory Cancer-Associated Fibroblast-Based Subtypes with Promising Implications in Predicting the Prognosis and Immunotherapeutic Response of Bladder Cancer Patients." International Journal of Molecular Sciences 23, no. 24 (2022): 15970. http://dx.doi.org/10.3390/ijms232415970.

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Inflammatory cancer-associated fibroblasts (iCAFs) are closely related to progression, anticancer therapeutic resistance, and poor prognosis of bladder cancer (BCa). However, the functional role of iCAFs in BCa has been poorly studied. In our study, two BCa scRNA-seq datasets (GSE130001 and GSE146137) were obtained and integrated by the Seurat pipeline. Based on reported markers (COL1A1 and PDGFRA), iCAFs were identified and the related signature of 278 markers was developed. Following unsupervised consensus clustering, two molecular subtypes of TCGA-BLCA were identified and characterized by d

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Ma, Shuwei, and Yi Qiao. "Molecular mechanism of IL17A-IL17F involved in children with allergic rhinitis through IL17RC-IL33-NF-kB signaling axis." Materials Express 12, no. 5 (2022): 668–74. http://dx.doi.org/10.1166/mex.2022.2200.

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Objective: Allergic rhinitis (AR) is a common chronic nasal mucosal congestion disease of children, and its pathogenesis is associated with immune factors. Methods: 50 cases of children were collected and their nasal mucus was used to detect inflammatory factors IL-17A, IL-17F and IL-33 level, as well as the proportion of ILC2 and Th2 in blood labeled by flow cytometry. In addition, the allergic rhinitis model of immature mice was established. HE staining was used to observe nasal mucosa. IgE, IL-17A, IL-17F and IL-33 levels were detected, and the ratio of ILC2 and Th2 in blood was marked by f

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Chen, Suning, Bjoern Schneider, Stefan Nagel, et al. "Spliceosomal Targeting in Acute Myeloid Leukemia Cells with ETV6-NTRK3 Fusion." Blood 114, no. 22 (2009): 5042. http://dx.doi.org/10.1182/blood.v114.22.5042.5042.

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Abstract Abstract 5042 Background In acute myeloid leukemia (AML) a recurrent chromosome abnormality t(12;15)(p13;q25) fuses ETV6 with NTRK3. This rearrangement uniquely occurs in both solid tumors – including secretory breast cancer where it has been recently shown to target WNT signalling (Li et al., Cancer Cell 2007, 12: 542) - and leukemia, but has yet to be characterized in the hematologic setting. Tyrosine receptor kinases (TRK) play key roles in leukemogenesis and already serve as therapeutic targets. We set out to characterize potential downstream targets of ETV6-NTKR3 in AML cells. Me

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Yano, Hiroshi, Deepali V. Sawant, Mengting Liao, et al. "Inhibitory cytokines mark distinct subpopulations of intratumoral regulatory T cells." Journal of Immunology 198, no. 1_Supplement (2017): 155.7. http://dx.doi.org/10.4049/jimmunol.198.supp.155.7.

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Abstract Regulatory T cells (Tregs) play a crucial role in the maintenance of self-tolerance and the resolution of inflammation; however, they also negatively regulate anti-tumor immunity by contributing to the immunosuppressive tumor microenvironment. Our previous studies have shown that the inhibitory cytokine interleukin-35 (IL35), a member of the IL12 cytokine family, is preferentially expressed by activated Tregs and the IL35 expression is required for the maximum suppressive activity of Tregs. To investigate the role of Treg-derived IL35 in the tumor microenvironment, we generated a Treg

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Fogel, O., E. Rivière, R. Seror, et al. "AB0150 Understanding The Role of The IL12/iL35 Balance in Sjögren Syndrome." Annals of the Rheumatic Diseases 75, Suppl 2 (2016): 948.1–948. http://dx.doi.org/10.1136/annrheumdis-2016-eular.5756.

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mathur, Ramkumar, Yuan Liao, Xiaofeng Zhao, Yunfei Huang, and Xinjun Zhu. "IL23/MTOR Axis in CX3CR1 Residential Macrophages Modulates IL22-Mediated Intestinal Fibrosis." Gastroenterology 152, no. 5 (2017): S612. http://dx.doi.org/10.1016/s0016-5085(17)32176-5.

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Ayari, Jihene Braham, Shourouk Haj Ammar, Mehdi Balti, et al. "Prognostic value of circulating cytokines in breast cancer: A prospective study in sixty breast cancer patients in Tunisia." Journal of Clinical Oncology 37, no. 15_suppl (2019): e12592-e12592. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e12592.

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e12592 Background: Breast cancer is the second most common cancer and the fifth most common cause of cancer mortality worldwide. The functional relationship between inflammation and cancer is an old concept of cancero- genesis, and it is now clear that inflammatory process certainly potentiates and/or promotes neoplastic risk. However, many of the molecular and cellular mechanisms mediating this relationship remain unresolved. The aim of this study is to measure the level of circulating cytokines (IL17, IL6, IL22, IL23 and TNFα) in breast cancer patients in Tunisia, and to evaluate their impli

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