Journal articles: 'II-IV-N₂'

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Sargar, B. M., M. M. Rajmane, and M. A. Anuse. "Selective liquid-liquid extraction of antimony(III) from hydrochloric acid media by N-n-octylaniline in xylene." Journal of the Serbian Chemical Society 69, no. 4 (2004): 283–98. http://dx.doi.org/10.2298/jsc0404283s.

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N-n-Octylaniline in xylene was used for the extraction separation of antimony( III) from hydrochloric acid media. Antimony(III) was extracted quantitatively with 10 mL4%N-n-octylaniline in xylene. It was stripped from the organic phase with 0.5 M ammonia and estimated photometrically by the iodide method. The effect of metal ion, acid, reagent concentration and various foreign ions was investigated. The method affords binary and ternary separation of antimony(III) from tellurium(IV), selenium( IV), lead(II) bismuth(III), tin(IV), germanium(IV), copper(II), gold(III), iron(III) and zinc(II). The method is applicable for the analysis of synthetic mixtures alloys and semiconductor thin films. It is fast, accurate and precise.

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Corrégé, G., and A. Hibbert. "Transitions in C II, N III, and O IV." Atomic Data and Nuclear Data Tables 86, no. 1 (January 2004): 19–34. http://dx.doi.org/10.1016/j.adt.2003.11.002.

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Nisbet, Matthew L., and Kenneth R. Poeppelmeier. "Crystal structures of [Cu(phen)(H2O)3(MF6)]·H2O (M = Ti, Zr, Hf) and [Cu(phen)(H2O)2F]2[HfF6]·H2O." Acta Crystallographica Section E Crystallographic Communications 77, no. 2 (January 26, 2021): 165–70. http://dx.doi.org/10.1107/s2056989021000645.

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The crystal structures of three bridged bimetallic molecular compounds, namely, triaqua-2κ3 O-μ-fluorido-pentafluorido-1κ5 F-(1,10-phenanthroline-2κ2 N,N′)copper(II)titanium(IV) monohydrate, [Cu(TiF6)(phen)(H2O)3]·H2O (phen is 1,10-phenanthroline, C12H8N2), (I), triaqua-2κ3 O-μ-fluorido-pentafluorido-1κ5 F-(1,10-phenanthroline-2κ2 N,N′)copper(II)zirconium(IV) monohydrate, [Cu(ZrF6)(phen)(H2O)3]·H2O, (II), and triaqua-2κ3 O-μ-fluorido-pentafluorido-1κ5 F-(1,10-phenanthroline-2κ2 N,N′)copper(II)hafnium(IV) monohydrate, [Cu(HfF6)(phen)(H2O)3]·H2O, (III), and one molecular salt, bis[diaquafluorido(1,10-phenanthroline-κ2 N,N′)copper(II)] hexafluoridohafnate(IV) dihydrate, [CuF(phen)(H2O)2]2[HfF6]·2H2O, (IV), are reported. The bridged bimetallic compounds adopt Λ-shaped configurations, with the octahedrally coordinated copper(II) center linked to the fluorinated early transition metal via a fluoride linkage. The extended structures of these Λ-shaped compounds are organized through both intra- and intermolecular hydrogen bonds and intermolecular π–π stacking. The salt compound [Cu(phen)(H2O)2F]2[HfF6]·H2O displays an isolated square-pyramidal Cu(phen)(H2O)2F+ complex linked to other cationic complexes and isolated HfF6 2− anions through intermolecular hydrogen-bonding interactions.

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Ojala, William, Kendra Lystad, Jonathan Smieja, Jaclyn Fermanich, and Charles Ojala. "Nitrile-Halogen Interactions in Some Bridge-Flipped Isomeric Benzylideneanilines." Acta Crystallographica Section A Foundations and Advances 70, a1 (August 5, 2014): C663. http://dx.doi.org/10.1107/s205327331409336x.

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We designate as "bridge-flipped isomers" those pairs of molecules that differ only in the orientation of a bridge of atoms linking two major molecular fragments: in benzylideneanilines, Ar-CH=N-Ar' vs. Ar-N=CH-Ar'; in phenylhydrazones, Ar-NH-N=CH-Ar' vs. Ar-CH=N-NH-Ar' (Ar = aryl). We use them as a context in which to evaluate the roles of molecular conformation, hydrogen bonding, space-filling requirements, and supramolecular synthons in establishing crystalline isomorphism or non-isomorphism. To examine nitrile-halogen and halogen-halogen interactions in solid isomeric benzylideneanilines, we have determined the structures of 2-cyanobenzylidene-2'-iodoaniline (I), 2-iodobenzylidene-2'-cyanoaniline (II), 2-cyanobenzylidene-2'-bromoaniline (III), 2-cyanobenzylidene-2'-chloroaniline (IV), and 2-chlorobenzylidene-2'-cyanoaniline (V) by single-crystal X-ray diffraction. I/II and IV/V are bridge-flipped isomeric pairs. I, III, and IV are isomorphous; the I/II and IV/V pairs are not. In I, III, and IV, translationally related molecules are linked into chains by C≡N···X contacts; no close X···X contacts occur. Although C≡N···X contacts between translationally related molecules define chains in II similar to those in I, III, and IV, and although II likewise lacks close X···X contacts, the molecular packing arrangements differ (monoclinic for I, III, and IV vs. triclinic for II). V in contrast assumes an orthorhombic structure from which the C≡N···X interaction is absent and which is isomorphous with 2-chlorobenzylidene-2'-chloroaniline (VI), the nitrile group of V exchanged for the aniline-side chlorine of VI, that chlorine atom in VI not involved in a close intermolecular Cl···Cl contact. Although neither C≡N···X nor X···X contacts result in isomorphous bridge-flipped isomers in the cases of I/II and IV/V, the C≡N···X contacts apparently play a major structure-defining role and supersede any potential X···X contacts in I-IV.

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Cunha-Silva, Luís, Fa-Nian Shi, Jacek Klinowski, Tito Trindade, João Rocha, and Filipe A. Almeida Paz. "Decaaquadioxidobis[μ3-N-(phosphonatomethyl)iminodiacetato]dizinc(II)divanadium(IV) dihydrate." Acta Crystallographica Section E Structure Reports Online 64, no. 1 (December 6, 2007): m39—m40. http://dx.doi.org/10.1107/s1600536807062253.

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Lynch, Sheridan, Genevieve Lynch, Will E. Lynch, and Clifford W. Padgett. "Crystal structures of four dimeric manganese(II) bromide coordination complexes with various derivatives of pyridine N-oxide." Acta Crystallographica Section E Crystallographic Communications 75, no. 8 (July 30, 2019): 1284–90. http://dx.doi.org/10.1107/s2056989019010557.

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Four manganese(II) bromide coordination complexes have been prepared with four pyridine N-oxides, viz. pyridine N-oxide (PNO), 2-methylpyridine N-oxide (2MePNO), 3-methylpyridine N-oxide (3MePNO), and 4-methylpyridine N-oxide (4MePNO). The compounds are bis(μ-pyridine N-oxide)bis[aquadibromido(pyridine N-oxide)manganese(II)], [Mn2Br4(C5H5NO)4(H2O)2] (I), bis(μ-2-methylpyridine N-oxide)bis[diaquadibromidomanganese(II)]–2-methylpyridine N-oxide (1/2), [Mn2Br4(C6H7NO)2(H2O)4]·2C6H7NO (II), bis(μ-3-methylpyridine N-oxide)bis[aquadibromido(3-methylpyridine N-oxide)manganese(II)], [Mn2Br4(C6H7NO)4(H2O)2] (III), and bis(μ-4-methylpyridine N-oxide)bis[dibromidomethanol(4-methylpyridine N-oxide)manganese(II)], [Mn2Br4(C6H7NO)4(CH3OH)2] (IV). All the compounds have one unique MnII atom and form a dimeric complex that contains two MnII atoms related by a crystallographic inversion center. Pseudo-octahedral six-coordinate manganese(II) centers are found in all four compounds. All four compounds form dimers of Mn atoms bridged by the oxygen atom of the PNO ligand. Compounds I, II and III exhibit a bound water of solvation, whereas compound IV contains a bound methanol molecule of solvation. Compounds I, III and IV exhibit the same arrangement of molecules around each manganese atom, ligated by two bromide ions, oxygen atoms of two PNO ligands and one solvent molecule, whereas in compound II each manganese atom is ligated by two bromide ions, one O atom of a PNO ligand and two water molecules with a second PNO molecule interacting with the complex via hydrogen bonding through the bound water molecules. All of the compounds form extended hydrogen-bonding networks, and compounds I, II, and IV exhibit offset π-stacking between PNO ligands of neighboring dimers.

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Lázaro, Ariadna, Oriol Serra, Laura Rodríguez, Margarita Crespo, and Mercè Font-Bardia. "Luminescence studies of new [C,N,N′] cyclometallated platinum(ii) and platinum(iv) compounds." New Journal of Chemistry 43, no. 3 (2019): 1247–56. http://dx.doi.org/10.1039/c8nj05492d.

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Shaker, Shayma A. "Preparation and Spectral Properties of Mixed-Ligand Complexes of VO(IV), Ni(II), Zn(II), Pd(II), Cd(II) and Pb(II) with Dimethylglyoxime andN-acetylglycine." E-Journal of Chemistry 7, s1 (2010): S580—S586. http://dx.doi.org/10.1155/2010/125136.

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A number of mixed-ligand complexes of the general formula [M(D)(G)] where D=dimethylglyoximato monoanion, G=N-acetylglycinato and M=VO(IV), Ni(II), Zn(II), Pd(II), Cd(II) and Pb(II) were prepared. Each complex was characterized by elemental analysis, determination of metal, infrared spectra, electronic spectra, (1H and13C) NMR spectra, conductivity and magnetic moments. All these complexes were not soluble in some of the organic solvent but highly soluble in dimethylformamide. The conductivity data showed the non-electrolytic nature of the complexes. The electronic spectra exhibited absorption bands in the visible region caused by the d-d electronic transition such as VO(IV), Ni(II) and Pd(II). The IR and (1H,13C) NMR spectra which have indicate that the dimethylglyoxime was coordinated with the metal ions through the N and O atoms of the oxime group andN-acetylglycine was coordinated with metal ions through the N atom and terminal carboxyl oxygen atom.

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Roemmich, James N., Pamela A. Clark, Arthur Weltman, and Alan D. Rogol. "Alterations in growth and body composition during puberty. I. Comparing multicompartment body composition models." Journal of Applied Physiology 83, no. 3 (September 1, 1997): 927–35. http://dx.doi.org/10.1152/jappl.1997.83.3.927.

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Roemmich, James N., Pamela A. Clark, Arthur Weltman, and Alan D. Rogol. Alterations in growth and body composition during puberty. I. Comparing multicompartment body composition models. J. Appl. Physiol. 83(3): 927–935, 1997.—A four-compartment (4C) model of body composition was used as a criterion to determine the accuracy of three-compartment (3C) and two-compartment (2C) models to estimate percent body fat (%BF) in prepubertal and pubertal boys (genital I & II, n = 17; genital III & IV, n = 7) and girls (breast I & II, n = 8; breast III & IV, n = 15). The 3C water-density (3C-H2O) and 3C mineral-density models, dual-energy X-ray absorptiometry, the Lohman age-adjusted equations, the Slaughter et al. skinfold equations, and the Houtkooper et al. and Boileau bioelectrical impedance equations were evaluated. Agreement with the 4C model increased with the number of compartments (i.e., body water, bone mineral) measured. Except for the 3C-H2O model, the limits of agreement were large and did not perform well for individuals. The mean %BF by dual-energy X-ray absorptiometry (23.6%) was greater than that of the criterion 4C method (21.7%). For the field methods, the Slaughter et al. skinfold equations performed better than did the Houtkooper et al. and Boileau bioimpedance equations. The hydration of the fat-free mass decreased (genital I & II = 75.7%, genital III & IV = 74.8%, breast I & II = 75.5%, breast III & IV = 74.4%) and the mineral content increased (genital I & II = 4.9%, genital III & IV = 5.0%, breast I & II = 5.1%, breast III & IV = 5.7%) with maturation. The density of the fat-free mass also increased (genital I & II = 1.084 g/ml, genital III & IV = 1.087 g/ml, breast I & II = 1.086 g/ml, breast III & IV = 1.091 g/ml) with maturation. All of the models reduced the %BF overprediction of the Siri 2C model, but only the 4C and 3C-H2O models should be used as criterion methods for body composition validation in children and adolescents.

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MELCHER, Ralph, Alexandra HILLEBRAND, Ute BAHR, Bernd SCHRÖDER, Michael KARAS, and Andrej HASILIK. "Glycosylation-site-selective synthesis of N-acetyl-lactosamine repeats in bis-glycosylated human lysozyme." Biochemical Journal 348, no. 3 (June 7, 2000): 507–15. http://dx.doi.org/10.1042/bj3480507.

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We have studied the elongation of oligosaccharides containing N-acetyl-lactosamine repeats using glycosylated human lysozyme mutants as a model. We reported previously that a combination of glycosylation sites at the 49th (site IV) and 68th (site II) amino acid residues of the protein particularly stimulates the synthesis of N-acetyl-lactosamine repeats [Melcher, Grosch, Grosse and Hasilik (1998) Glycoconjugate J. 15, 987-993]. In the present study we show that it is the carbohydrate attached to site IV that is selectively affected. It contains more N-acetyl-lactosamine repeats when site II is glycosylated in the same molecule. As a corollary of the glycosylation at site II, the synthesis of a third antenna at site IV is increased. The triantennary oligosaccharides at site IV contain more N-acetyl-lactosamine repeats than the biantennary ones. Thus placing a carbohydrate at site II stimulates the branching and the elongation of the carbohydrate at the other site.

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Abbas Ali, Wissam, Hayder Mihsen, and Sajid H. Guzar. "Synthesis, Characterization and Antibacterial Activity of Sn(II) and Sn(IV) Ions Complexes Containing N-Alkyl-N-Phenyl Dithiocarbamate Ligands." Chemistry & Chemical Technology 17, no. 4 (December 25, 2023): 729–39. http://dx.doi.org/10.23939/chcht17.04.729.

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In the current study, ligands S2 donor atoms, sodium N-methyl-N-phenyldithiocarbamate [L1], and sodium N-ethyl-N-phenyldithiocarbamate [L2] are prepared from carbon disulfide with N-methyl aniline and N-ethyl aniline, respectively. Sn(II) and Sn(IV) ions complexes containing N-alkyl-N-Phenyl dithiocarbamateare prepared and characterized by CHNS elemental analysis, infrared spectroscopy (FT-IR), 1HNMR-spectroscopy, mass spectroscopy, UV-visible spectroscopy, magnetic susceptibility and conductivity measurements. The analytical and spectral data show that the stoichiometry for all complexes is 1 : 2 metal to ligand. The spectral data confirm good coordination of dithiocarbamate ligand with the metal through sulfur atoms of dithiocarbamate moiety. Molar conductivity of complexes are measured using DMF as a solvent and indicated that the complexes of Sn(II) are non-ionic whereas Sn(IV) complexes are ionic. The ligands L1 and L2 and their complexes are examined against Staphylococcus aureus bacteria and Escherichia coli bacteria.

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Cojocaru, Cosmin, Aura-Elena Vîjîiac, Oana Gheorghe-Fronea, Teodora Mohaiu, Lucian Itu, and Maria Dorobanțu. "Nine-Year Trends in Atrial Fibrillation Prevalence among Romanian Adult Hypertensives: A Post-Hoc Analysis of SEPHAR II-IV Surveys." International Journal of Environmental Research and Public Health 19, no. 15 (July 28, 2022): 9250. http://dx.doi.org/10.3390/ijerph19159250.

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Objectives: There are limited epidemiological data regarding atrial fibrillation (AF) in hypertensive (HT) Romanian adults. We sought to evaluate AF prevalence trends in the SEPHAR surveys (Study for Evaluation of Prevalence of Hypertension and Cardiovascular Risk in an Adult Population in Romania) during a nine-year interval (2012–2016–2021). Methods: Three consecutive editions of a national epidemiological survey regarding HT included representative samples of subjects stratified by age, gender and area of residence (SEPHAR II-IV—in total, 5422 subjects, mean age 48.69 ± 16.65 years, 57.5% (n = 3116) females). A post-hoc analysis of AF prevalence and oral anticoagulation (OAC) rates was performed. AF definition was based on a documented medical history of AF and/or AF documentation by study electrocardiogram. Results: General AF prevalence was 5.5% (n = 297). AF prevalence in HT subjects was 8.9% (n = 209) and has risen since SEPHAR II—7.2% (n = 57) and SEPHAR III—8.1% (n = 72) to SEPHAR IV—11.8% (n = 80), respectively (p = 0.001). AF prevalence has increased in HT males (SEPHAR II—5.3% (n = 19), SEPHAR III—7.6% (n = 26) and SEPHAR IV—11.7% (n = 35) (p = 0.010)) and in HT from urban areas (SEPHAR II—7.8% (n = 37), SEPHAR III—7.8% (n = 40), SEPHAR IV—14.7% (n = 50), p < 0.001). In SEPHAR III-IV, only 19.3% (n = 23) of HT AF patients with OAC indication were anticoagulated. Conclusions: AF prevalence has increased by ~64% in hypertensive Romanian adults between 2012 and 2021. However, anticoagulation strategies may be suboptimal in patients with cardioembolic risk.

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Ciccarese, A., D. A. Clemente, F. P. Fanizzi, A. Marzotto, and G. Valle. "Synthesis and molecular structure of N-methylpiperazinium(+1) and N,N′-dimethylpiperazinium(+2) platinum(II) and platinum(IV) complexes Part II." Inorganica Chimica Acta 275-276 (July 1998): 419–26. http://dx.doi.org/10.1016/s0020-1693(98)00067-x.

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Jakubas, R., G. Bator, M. Foulon, J. Lefebvre, and J. Matuszewski. "Structural Phase Transitions in (n-C3H7NH3)2SbBr5." Zeitschrift für Naturforschung A 48, no. 3 (March 1, 1993): 529–34. http://dx.doi.org/10.1515/zna-1993-0314.

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Abstract Dielectric, DSC, thermal expansion and preliminary X-ray diffraction studies on (n-C3H7NH3)- SbBr5 are reported. It was found that this crystal undergoes a complex sequence of phase transitions. On cooling: phase I → phase II at 188.7 K (continuous), II → III at 165 K (1st order, ΔS = 26.8 J/mol K), III → IV at 137 K (1st order, 1.6 J/mol K). On heating: IV → III at 154 K, III → II’ at 168 K, II’ → II at 177 K (1st order, 2.8 J/mol K), II → I at 189 K. All 1st order phase transitions are likely due to the motion of the n-C3H7NH3+cations. The dielectric dispersion studies between 100 Hz-1 MHz within the phases I and II indicate a fast reorientational motion of dipoles with τ < 10−7 S.

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Singh, Puspendra, Anand K. Gupta, Sagar Sharma, Harkesh B. Singh, and Ray J. Butcher. "Synthesis and characterization of N,N′,C-bound organotellurium(IV) and organomercury(II) derivatives." Inorganica Chimica Acta 483 (November 2018): 218–28. http://dx.doi.org/10.1016/j.ica.2018.08.016.

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Nisbet, Matthew L., Emily Hiralal, and Kenneth R. Poeppelmeier. "Crystal structures of three copper(II)–2,2′-bipyridine (bpy) compounds, [Cu(bpy)2(H2O)][SiF6]·4H2O, [Cu(bpy)2(TaF6)2] and [Cu(bpy)3][TaF6]2 and a related coordination polymer, [Cu(bpy)(H2O)2SnF6] n." Acta Crystallographica Section E Crystallographic Communications 77, no. 2 (January 26, 2021): 158–64. http://dx.doi.org/10.1107/s2056989021000633.

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We report the hydrothermal syntheses and crystal structures of aquabis(2,2′-bipyridine-κ2 N,N′)copper(II) hexafluoridosilicate tetrahydrate, [Cu(bpy)2(H2O)][SiF6]·4H2O (bpy is 2,2′-bipyridine, C10H8N2), (I), bis(2,2′-bipyridine-3κ2 N,N′)-di-μ-fluorido-1:3κ2 F:F;2:3κ2 F:F-decafluorido-1κ5 F,2κ5 F-ditantalum(V)copper(II), [Cu(bpy)2(TaF6)2], (II), tris(2,2′-bipyridine-κ2 N,N′)copper(II) bis[hexafluoridotantalate(V)], [Cu(bpy)3][TaF6]2, (III), and catena-poly[[diaqua(2,2′-bipyridine-κ2 N,N′)copper(II)]-μ-fluorido-tetrafluoridotin-μ-fluorido], [Cu(bpy)(H2O)2SnF6] n , (IV). Compounds (I), (II) and (III) contain locally chiral copper coordination complexes with C 2, D 2, and D 3 symmetry, respectively. The extended structures of (I) and (IV) are consolidated by O—H...F and O—H...O hydrogen bonds. The structure of (III) was found to be a merohedral (racemic) twin.

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Mogensen, O., F. B. SØRensen, P. Bichel, and A. Jakobsen. "Nuclear volume and prognosis in ovarian cancer." International Journal of Gynecologic Cancer 2, no. 3 (1992): 141–46. http://dx.doi.org/10.1046/j.1525-1438.1992.02030141.x.

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The prognostic value of the volume-weighted mean nuclear volume (MNV) was investigated retrospectively in 100 ovarian cancer patients with FIGO-stage IB–II (n= 51) and stage III–IV (n= 49) serous tumors. No association was demonstrated between the MNV and the survival or between the MNV and two of five additional parameters: age and amount of residual tumor. However, both in stage IB–II and stage III–IV carcinomas, the MNV increased significantly with increasing tumor grade and DNA-index. Furthermore, FIGO-stage IB–II patients had significantly smaller nuclei than patients with stage III–IV disease.

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Furuya, Valéria Rossetto Barriviera, Wilson Massamitu Furuya, Mariana Michelato, Ana Lúcia Salaro, Makoto Matsushita, and Weliton Pedro Batiston. "Composição proximal e perfil de ácidos graxos do lambari-do-rabo-vermelho (Astyanax fasciatus) de diferentes classes de peso." Revista Brasileira de Saúde e Produção Animal 14, no. 4 (December 2013): 820–30. http://dx.doi.org/10.1590/s1519-99402013000400020.

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O trabalho foi realizado com o objetivo de avaliar a composição proximal e perfil de ácidos graxos de lambaris-do-rabo-vermelho de acordo com a classe de peso corporal: Classe I (3,24 - 4,46g); Classe II (9,08 - 11,62g); Classe III (15,8 - 18,89g) e Classe IV (32,25 - 54,64g). Não foi observado efeito do peso corporal sobre o conteúdo de cinzas corporal dos peixes. Os peixes de Classe I apresentaram maiores teores de umidade e menores teores de lipídios corporal em relação aos peixes das classes II, III e IV. O maior nível de lipídios foi observado em peixes da Classe IV e não sendo observadas diferenças entre peixes das Classes II, III e IV. O ácido palmitico (16:0) e oléico (18:1 n-9) foram os ácidos graxos saturados e monoinsaturados mais abundantes, respectivamente, independentemente da classe de peso dos peixes. A quantidade total de ácidos graxos saturados foi maior nos peixes da Classe I, que também apresentaram níveis mais elevados dos ácidos palmítico, linoléico e docohexaenóico. Os peixes de Classe II, III e IV apresentaram maior relação de ácidos graxos n-3/n-6 em comparação com os peixes da Classe I, porém os peixes de todas as classes de peso demonstraram valor nutricional satisfatório para consumo humano em termos de proteína bruta, lipídios e relações de ácidos graxos n-3/n-6 e AGP/AGS.

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Blasi-Brugué, Carles, Icíar Martínez-Flórez, Marta Baxarias, Joan del Rio-Velasco, and Laia Solano-Gallego. "Exploring the Relationship between Neutrophil Activation and Different States of Canine L. infantum Infection: Nitroblue Tetrazolium Test and IFN-γ." Veterinary Sciences 10, no. 9 (September 13, 2023): 572. http://dx.doi.org/10.3390/vetsci10090572.

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This study aimed to investigate the role of neutrophils in canine leishmaniosis by assessing neutrophil activation and its relationship with different states of L. infantum infection and antibody and IFN-γ production. Dogs were categorized into five groups: healthy-seronegative (n = 25), healthy-seropositive (n = 21), LeishVet-stage I (n = 25), Leishvet-stage II (n = 41), and LeishVet-stage III–IV (n = 16). Results of the nitroblue tetrazolium reduction test (NBT) showed significantly higher neutrophil activation in stage I (median:17.17, range: [7.33–31.50]%) compared to in healthy-seronegative (4.10 [1.20–18.00]%), healthy-seropositive (7.65 [3.98–21.74]%), stage II (6.50 [1.50–28.70]%), and stage III–IV (7.50 [3.00–16.75]%) groups (p < 0.0001). Healthy-seropositive dogs also displayed higher values than all groups except stage I. Stages II and III–IV did not show significant differences compared to healthy-seronegative. Regarding IFN-γ, stage I dogs had higher concentrations (median:127.90, range: [0–3998.00] pg/mL) than healthy-seronegative (0 [0–109.50] pg/mL) (p = 0.0002), stage II (9.00 [0–5086.00] pg/mL) (p = 0.045), and stage III–IV (3.50 [80.00–548.80] pg/mL) (p = 0.02) dogs. Stage II dogs showed increased IFN-γ compared to healthy-seronegative dogs (p = 0.015), while stage III–IV dogs had no significant differences compared to healthy-seronegative dogs (p = 0.12). Healthy-seropositive dogs had elevated IFN-γ concentrations compared to healthy-seronegative dogs (p = 0.001) and dogs in stage III–IV (p = 0.03). In conclusion, neutrophil activation was higher in dogs with mild disease and healthy-seropositive dogs, and a relationship between neutrophil activation and the production of IFN-γ was found.

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Martin, Alain. "P. Brux. Inv. E. 6029 = S.P.P. IV, p. 55, n° II." Chronique d'Egypte 76, no. 151-152 (January 2001): 187–95. http://dx.doi.org/10.1484/j.cde.2.309169.

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Hasan, Masihul, Ivan V. Kozhevnikov, M. Rafiq H. Siddiqui, Cristina Femoni, Alexander Steiner, and Neil Winterton. "N,N‘-Dialkylimidazolium Chloroplatinate(II), Chloroplatinate(IV), and Chloroiridate(IV) Salts and anN-Heterocyclic Carbene Complex of Platinum(II): Synthesis in Ionic Liquids and Crystal Structures." Inorganic Chemistry 40, no. 4 (February 2001): 795–800. http://dx.doi.org/10.1021/ic000606o.

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Mijajlović, Marina Ž., Miloš V. Nikolić, Verica V. Jevtić, Zoran R. Ratković, Jelena Milovanović, Aleksandar Arsenijević, Bojana Stojanović, et al. "Cytotoxicity of platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid. Crystal structure of [Pd(1,2-dpheddp)] complex." Macedonian Journal of Chemistry and Chemical Engineering 35, no. 1 (April 18, 2016): 79. http://dx.doi.org/10.20450/mjcce.2016.729.

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The syntheses of tetradentate ligand, meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid (H2-1,2-dpheddp) and corresponding platinum(IV) and palladium(II) complexes are reported here. The spectroscopically predicted structure of the obtained palladium(II) complex was confirmed by X-ray analysis. Singe crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water mixture. Cytotoxic effects of platinum(IV), palladium(II) complexes and cisplatin on the 4T1 and B16F1 cell lines were determined using the MTT colorimetric technique. The complexes showed a dose dependence on cytotoxic effect toward both cell lines. Both complexes were less active than cisplatin, the exception was concentrations above 62.5 μM of platinum(IV) complex in the B16F1 cell line.

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Vijayakumar, Veeraragavan, Chidambaram Ramesh Kumar, Nagarajan Sivaraman, Ammath Suresh, Avinash S. Kanekar, Arunasis Bhattacharyya, and Prasanta K. Mohapatra. "Novel diamide ligands with a central carbonyl group and their comparative evaluation with the diglycolamide ligand: synthesis, extraction, DFT and chromatographic studies." Radiochimica Acta 107, no. 12 (November 26, 2019): 1133–44. http://dx.doi.org/10.1515/ract-2019-3102.

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Abstract The extraction behaviour of U(VI), Th(IV) and Nd(III) was investigated as a function of nitric acid concentration for diamide based extractants, namely, N,N,N′,N′-tetraoctyl-3-carbonylpentanediamide (TOCPDA) and 4-carbonyl-heptanedioic acid bis-dioctylamide (CHADA). In addition, the distribution ratio was also measured for Pu(IV) and Sr(II) with 1.1 M CHADA in n-dodecane. These extractants were synthesized by adopting simple acid, amine coupling reaction with DCC (dicyclohexylcarbodiimide) and DMAP (N,N′-dimethylaminopyridine) as the coupling agent. The newly synthesized extractants were characterized by FT-IR, NMR, Mass, CHNS and HPLC. The extraction results indicated that CHADA shown has better extraction behavior for U(VI) compared to TOCPDA. In addition, CHADA coated HPLC column was examined for the retention behaviour of U(VI), Th(IV), and Nd(III). Computation studies based on density functional theory (DFT) were carried out to understand the complexing behaviour of U(VI), Pu(IV) and Sr(II) with CHADMA and TMCPDA.

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Che, Hao, Yufang Lv, Fang Yao, Fang Zhao, and Liyun Zhao. "Mechanism of Sevoflurane Anesthesia under Hypothermic Cardiopulmonary Bypass on Postoperative Atrial Fibrillation Rhythm in Patients Undergoing Mitral Valve Replacement." BioMed Research International 2022 (June 28, 2022): 1–8. http://dx.doi.org/10.1155/2022/5312897.

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Objective. It was to investigate the mechanism of atrial fibrillation after mitral valve replacement under extracorporeal circulation in patients with rheumatic heart disease under sevoflurane anesthesia maintenance and to provide scientific and effective basis for clinical treatment. Methods. Forty patients with rheumatic heart disease who underwent mitral valve replacement were randomly rolled into group I (sinus rhythm of propofol anesthesia, n = 10 ), group II (atrial fibrillation rhythm of propofol anesthesia, n = 10 ), group III (sinus rhythm of sevoflurane anesthesia, n = 10 ), and group IV (atrial fibrillation rhythm of sevoflurane anesthesia, n = 10 ). Inflammatory factors, free tissue of right atrium, and incidence of postoperative atrial fibrillation were compared among all groups. Results. (i) The serum levels of NT-proBNP, CRP, sST-2, IL-6, TNF-α, and TGF-β1 in group II were higher than those in group I, group III, and group IV, and the indexes in group III were higher than those in group IV ( P < 0.05 ). (ii) The relative expression levels of PLB, CaMK II, Bax, and TP53 in the free tissue of right atrium in group II were higher than those in group I, III, and IV, and the index levels in group IV were higher than those in group III ( P < 0.05 ). (iii) The incidence of postoperative atrial fibrillation in group III (0.00%) was significantly lower than that in group I (30%), group II (50%), and group IV (40.0%), and group II (50%) was the highest ( P < 0.05 ). Conclusion. The maintenance of sevoflurane anesthesia can improve the inflammatory response and myocardial tissue autophagy in patients with sinus rhythm and atrial fibrillation rhythm and can reduce the incidence of postoperative atrial fibrillation in patients.

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Tabe, Hiroyasu, Masaaki Matsushima, Rika Tanaka, and Yusuke Yamada. "Creation and stabilisation of tuneable open metal sites in thiocyanato-bridged heterometallic coordination polymers to be used as heterogeneous catalysts." Dalton Transactions 48, no. 45 (2019): 17063–69. http://dx.doi.org/10.1039/c9dt03679b.

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A series of {M^II[Pt^IV(SCN)₆]}_n and {M^II(CH₃OH)_x[Pt^IV(SCN)₆]}_n were characterised by single-crystal X-ray analyses and examined as heterogeneous catalysts to clarify the requisites for better catalysis.

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Nayak, Prakash S., Jerry P. Jasinski, James A. Golen, Badiadka Narayana, Manpreet Kaur, Hemmige S. Yathirajan, and Christopher Glidewell. "HalogenatedC,N-diarylacetamides: molecular conformations and supramolecular assembly." Acta Crystallographica Section C Structural Chemistry 70, no. 9 (August 23, 2014): 889–94. http://dx.doi.org/10.1107/s2053229614018713.

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The structures of four halogenatedN,2-diarylacetamides are reported and compared with a range of analogues.N-(4-Chloro-3-methylphenyl)-2-phenylacetamide, C15H14ClNO, (I), andN-(4-bromo-3-methylphenyl)-2-phenylacetamide, C15H14BrNO, (II), are isostructural in the space groupP\overline{1}. The molecules of (I) and (II) are linked into chains of rings by a combination of N—H...O and C—H...π(arene) hydrogen bonds. The molecules ofN-(4-chloro-3-methylphenyl)-2-(2,4-dichlorophenyl)acetamide, C15H12Cl3NO, (III), andN-(4-bromo-3-methylphenyl)-2-(2-chlorophenyl)acetamide, C15H13BrClNO, (IV), are linked into simpleC(4) chains by N—H...O hydrogen bonds, but significant C—H...π(arene) interactions are absent. TheN-aryl groups in compounds (III) and (IV) adopt a different orientation, byca180°, from that of the corresponding groups in compounds (I) and (II), but otherwise the conformations of (I)–(IV) are very similar. Comparisons are drawn between compounds (I) and (IV) and a range of analogues of the typeR1CH2CONHR2, whereR2represents a halogenated aryl ring andR1represents either another halogenated aryl ring or a naphthalen-1-yl unit.

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Campagnole-Santos, M. J., S. B. Heringer, E. N. Batista, M. C. Khosla, and R. A. Santos. "Differential baroreceptor reflex modulation by centrally infused angiotensin peptides." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 263, no. 1 (July 1, 1992): R89—R94. http://dx.doi.org/10.1152/ajpregu.1992.263.1.r89.

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The present study was designed to investigate the effect of intracerebroventricular (icv) and intravenous (iv) infusion of angiotensin (ANG)-(1-7), ANG III, and ANG II on the baroreceptor control of heart rate (BHR) in conscious rats. Reflex changes in HR were elicited by bolus iv injection of either phenylephrine or sodium nitroprusside before and within 1 and 3 h of icv infusion of ANG II (n = 10), ANG III (n = 9), ANG-(1-7) (n = 9), or saline (n = 9) at a rate of 3 nmol.7.5 microliter-1.h-1. In another group of animals (n = 23), iv infusion of the same amount of ANG peptides was carried out at a rate of 0.7 ml/h. The average ratio of changes in HR in beats per minute and changes in mean arterial pressure (MAP, mmHg) was used as an index of BHR sensitivity. ANG II and ANG III produced a significant increase in the basal levels of MAP, but only during the first hour of infusion (iv or icv). No significant changes in baseline HR were observed. ANG-(1-7) and saline infusion did not change basal levels of HR or MAP (iv or icv). ANG II (iv and icv) and ANG III (icv) caused a significant decrease in the BHR sensitivity for reflex bradycardia. In contrast, icv infusion of ANG-(1-7) induced a significant increase in BHR sensitivity for reflex bradycardia (-3.0 +/- 0.3, 1 h, and -2.8 +/- 0.1 beats.min-1.mmHg-1, 3 h vs. -2.1 +/- 0.2 beats.min-1.mmHg-1, before infusion).(ABSTRACT TRUNCATED AT 250 WORDS)

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Holý, Antonín, Ivan Rosenberg, and Hana Dvořáková. "Synthesis of N-(2-(2-phosphonylethoxy)ethyl) derivatives of heterocyclic bases." Collection of Czechoslovak Chemical Communications 55, no. 3 (1990): 809–18. http://dx.doi.org/10.1135/cccc19900809.

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Reaction of bis(2-chloroethyl) ether (II) with triethyl phosphite afforded diethyl 2-chloroethoxyethylphosphonate (III). This compound reacts with sodium salts of heterocyclic bases to give diethyl esters of N-(2-(2-phosphonylethoxy)ethyl) derivatives of purine and pyrimidine bases IV. Compounds IV on reaction with bromotrimethylsilane and subsequent hydrolysis were converted into N-(2-(phosphonylethoxy)ethyl) derivatives IV.

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Li, Ai-Guo, Qi-Kui Liu, Yan-An Li, Zhi-Xian Liu, and Yu-Bin Dong. "Three one-dimensional coordination polymers based on 1,1′-bis(pyridin-4-ylmethyl)-2,2′-bi-1H-benzimidazole and HgX2(X= Cl, Br and I)." Acta Crystallographica Section C Structural Chemistry 70, no. 1 (December 14, 2013): 37–42. http://dx.doi.org/10.1107/s2053229613031598.

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A new 2,2′-bi-1H-benzimidazole bridging organic ligand, namely 1,1′-bis(pyridin-4-ylmethyl)-2,2′-bi-1H-benzimidazole, C26H20N6,Lor (I), has been synthesized and used to create three new one-dimensional coordination polymers,viz.catena-poly[[dichloridomercury(II)]-μ-1,1′-bis(pyridin-4-ylmethyl)-2,2′-bi-1H-benzimidazole], [HgCl2(C26H20N6)]n, (II), and the bromido, [HgBr2(C26H20N6)]n, (III), and iodido, [HgI2(C26H20N6)]n, (IV), analogues. Free ligandLcrystallizes with two symmetry-independent half-molecules in the asymmetric unit and eachLmolecule resides on a crytallographic inversion centre. In structures (II)–(IV), theLligand is also positioned on a crystallographic inversion centre, whereas the Hg centre resides on a crystallographic twofold axis. Compound (I) adopts ananticonformation in the solid state and forms a two-dimensional network in the crystallographicbcplaneviaπ–π and C—H...π interactions. The three HgIIcoordination complexes, (II)–(IV), have one-dimensional zigzag chains composed ofLand HgX2(X= Cl, Br and I), and the HgIIcentres are in a distorted tetrahedral [HgX2N2] coordination geometry. Complexes (III) and (IV) are isomorphous, whereas complex (II) displays an interesting conformational difference from the others,i.e.a twist in the flexible bridging ligand.

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Silva, M., A. Humphrey, P. Lagos, and S. G. Morais. "Carbon-loud SDSS BOSS type II quasars at z > 2: high-density gas or secondary production of carbon?" Monthly Notices of the Royal Astronomical Society 495, no. 4 (June 2, 2020): 4707–46. http://dx.doi.org/10.1093/mnras/staa1409.

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ABSTRACT We study the ultraviolet (UV) emission-line ratios of a sample of 145 type II quasars (QSO2s) from Sloan Digital Sky Survey iii Baryon Oscillation Spectroscopic Survey, and compare against a grid of active galactic nucleus (AGN) photoionization models with a range in gas density, gas chemical abundances, and ionization parameter. Most of the quasars are ‘carbon-loud’, with C iv/He ii ratios that are unusually high for the narrow-line region, implying higher than expected gas density (>106 cm−3) and/or significantly supersolar-relative carbon abundance. We also find that solar or supersolar nitrogen abundance and metallicity are required in the majority of our sample, with potentially significant variation between objects. Compared to radio galaxies at similar redshifts (HzRGs; z > 2), the QSO2s are offset to higher N v/He ii, C iv/He ii, and C iii]/He ii, suggesting systematically higher gas density and/or systematically higher C and N abundances. We find no evidence for a systematic difference in the N/C abundance ratio between the two types of objects. Scatter in the N iv]/C iv ratio implies a significant scatter in the N/C abundance ratio among the QSO2s and HzRGs, consistent with differences in the chemical enrichment histories between objects. Interestingly, we find that adopting secondary behaviour for both N and C alleviates the long-standing ‘N iv] problem’. A subset of the QSO2s and HzRGs also appear to be ‘silicon-loud’, with Si iii] relative fluxes suggesting Si/C and Si/O are an order of magnitude above their solar values. Finally, we propose new UV-line criteria to select genuine QSO2s with low-density narrow-line regions.

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Macháček, Vladimír, Makky M. M. Hassanien, Vojeslav Štěrba, and Antonín Lyčka. "Formation of the Meisenheimer spiro adduct of N-(2,4,6-trinitrophenyl)alanine methylamide and its rearrangement to 2-amino-N-methyl-N-(2,4,6-trinitrophenyl)propanamide." Collection of Czechoslovak Chemical Communications 51, no. 9 (1986): 1972–85. http://dx.doi.org/10.1135/cccc19861972.

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N-(2,4,6-trinitrophenyl)alanine methylamide (I) undergoes base-catalyzed cyclization in methanol to give the spiro adduct II. In aniline-anilinium chloride buffers, the spiro adduct is protonated at the oxygen atom of 2-nitro group to give the neutral compound III. In 4-bromoaniline buffers or by action of methanolic hydrogen chloride, the compound III is opened to E and Z isomers of 2-amino-N-methyl-N-(2,4,6-trinitrophenyl)propanamide hydrochloride (IV). The rate-limiting step of cyclization of compound Z-IV to compound III consists in the isomerization Z-IV → E-IV. At higher pH values (acetate buffers), the rate-limiting step is gradually changed to the isomerization of 2-amino-N-methyl-N-(2,4,6-trinitrophenyl)propanamide (Z-V → E-V).

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Zhang, Lin, Wenyuan Liu, Sufen Li, Jinjing Wang, Dalin Sun, Hui Li, Ziyuan Zhang, Yaling Hu, and Jingai Fang. "Astragaloside IV alleviates renal fibrosis by inhibiting renal tubular epithelial cell pyroptosis induced by urotensin II through regulating the cAMP/PKA signaling pathway." PLOS ONE 19, no. 5 (May 31, 2024): e0304365. http://dx.doi.org/10.1371/journal.pone.0304365.

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Objective To explore the molecular mechanism of Astragaloside IV (AS-IV) in alleviating renal fibrosis by inhibiting Urotensin II-induced pyroptosis and epithelial-mesenchymal transition of renal tubular epithelial cells. Methods Forty SD rats were randomly divided into control group without operation: gavage with 5ml/kg/d water for injection and UUO model group: gavage with 5ml/kg/d water for injection; UUO+ AS-IV group (gavage with AS-IV 20mg/kg/d; and UUO+ losartan potassium group (gavage with losartan potassium 10.3mg/kg/d, with 10 rats in each group. After 2 weeks, Kidney pathology, serum Urotensin II, and cAMP concentration were detected, and the expressions of NLRP3, GSDMD-N, Caspase-1, and IL-1β were detected by immunohistochemistry. Rat renal tubular epithelial cells were cultured in vitro, and different concentrations of Urotensin II were used to intervene for 24h and 48h. Cell proliferation activity was detected using the CCK8 assay. Suitable concentrations of Urotensin II and intervention time were selected, and Urotensin II receptor antagonist (SB-611812), inhibitor of PKA(H-89), and AS-IV (15ug/ml) were simultaneously administered. After 24 hours, cells and cell supernatants from each group were collected. The cAMP concentration was detected using the ELISA kit, and the expression of PKA, α-SMA, FN, IL-1β, NLRP3, GSDMD-N, and Caspase-1 was detected using cell immunofluorescence, Western blotting, and RT-PCR. Results Renal tissue of UUO rats showed renal interstitial infiltration, tubule dilation and atrophy, renal interstitial collagen fiber hyperplasia, and serum Urotensin II and cAMP concentrations were significantly higher than those in the sham operation group (p <0.05). AS-IV and losartan potassium intervention could alleviate renal pathological changes, and decrease serum Urotensin II, cAMP concentration levels, and the expressions of NLRP3, GSDMD-N, Caspase-1, and IL-1β in renal tissues (p <0.05). Urotensin II at a concentration of 10−8 mol/L could lead to the decrease of cell proliferation, (p<0.05). Compared with the normal group, the cAMP level and the PKA expression were significantly increased (p<0.05). After intervention with AS-IV and Urotensin II receptor antagonist, the cAMP level and the expression of PKA were remarkably decreased (p<0.05). Compared with the normal group, the expression of IL-1β, NLRP3, GSDMD-N, and Caspase-1 in the Urotensin II group was increased (p<0.05), which decreased in the AS-IV and H-89 groups. Conclusion AS-IV can alleviate renal fibrosis by inhibiting Urotensin II-induced pyroptosis of renal tubular epithelial cells by regulating the cAMP/PKA signaling pathway.

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Sanchis-Perucho, Adrián, and José Martínez-Lillo. "Ferromagnetic exchange interaction in a new Ir(iv)–Cu(ii) chain based on the hexachloroiridate(iv) anion." Dalton Transactions 48, no. 37 (2019): 13925–30. http://dx.doi.org/10.1039/c9dt02884f.

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The new chloro-bridged heterobimetallic Ir^IVCu^II chain of formula {IrCl₅(μ-Cl)Cu(viim)₄}_n [viim = 1-vinylimidazole] is the first reported compound based on the Cu^II and Ir^IV metal ions.

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Bowes, Katharine F., George Ferguson, Alan J. Lough, and Christopher Glidewell. "The 1:1 adduct of triphenylsilanol and 4,4′-bipyridyl, and three pairwise-concomitant triclinic polymorphs of the 4:1 adduct having Z′ = 0.5, 1 and 4." Acta Crystallographica Section B Structural Science 59, no. 2 (March 26, 2003): 277–86. http://dx.doi.org/10.1107/s0108768103005196.

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Crystallization from methanol solution of mixtures of triphenylsilanol and 4,4′-bipyridyl has given a 1:1 adduct (I), Ph3SiOH·C10H8N2, and three polymorphic 4:1 adducts (II)–(IV), (Ph3SiOH)4·C10H8N2. In (I), the components are linked by a single O—H...N hydrogen bond and by a number of C—H...π(arene) hydrogen bonds to form a continuous three-dimensional structure. Compounds (II)–(IV) are all triclinic, space group P\bar 1, with Z′ values of 0.5, 1 and 4, respectively. The basic hydrogen-bonded aggregate is the same in each of (II)–(IV), having a pair of silanol molecules linked to the bipyridyl via O—N...N hydrogen bonds and a further pair of silanol molecules linked to the first pair via O—H...O hydrogen bonds. In (II) there is just one such aggregate lying across a centre of inversion (Z′ = 0.5) and in (III) there are two such aggregates, both lying across centres of inversion (Z′ = 2 × 0.5 = 1). In (IV) there are six independent aggregates of this type, four of which lie across centres of inversion and two of which lie in general positions, so that Z′ = (4 × 0.5) + 2 = 4. While the components in (I) are fully ordered, each of (II)–(IV) exhibits extensive disorder involving both the bipyridyl units and the phenyl rings of the silanol components.

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Raudaschl-Sieber, Gabriele, Bernhard Lippert, James F. Britten, and Andre L. Beauchamp. "N,N-dimethylacetamide adducts of mixed iodo-ammine complexes of platinum(II) and platinum(IV)." Inorganica Chimica Acta 124, no. 4 (August 1986): 213–17. http://dx.doi.org/10.1016/s0020-1693(00)83294-6.

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Цирульникова, Нина Владимировна, and Ольга Николаевна Подмарева. "Комплексы металлов с этилендиаминдикарбоновыми кислотами и их производными — перспективные фармакологические и диагностические агенты (обзор)." Химико-фармацевтический журнал 48, no. 11 (November 26, 2014): 28–33. http://dx.doi.org/10.30906/0023-1134-2014-48-11-28-33.

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Обобщены сведения по рассмотрению комплексов металлов с этилендиаминдикарбоновыми кислотами и их производными в качестве перспективных фармакологических и диагностических препаратов. Комплексы металлов платиновой группы являются перспективными противораковыми веществами. Для некоторых комплексов Pt(IV) и Pd(II) выявлены бактерицидные и фунгицидные свойства. Комплексы Zn(II) и Vo(IV) с этилендиамин-N,N’-дикарбоновыми кислотами рассматриваются в качестве гипогликемических (инсулиномиметических) средств. Комплексы металлов-нуклидов (99mTc, 111In, 67Ga) описаны в качестве диагностических радиофармацевтических препаратов.

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Jansen, W. T. M., M. M. Beitsma, C. J. Koeman, W. J. B. van Wamel, J. Verhoef, and A. C. Fluit. "Novel Mobile Variants of Staphylococcal Cassette Chromosome mec in Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 50, no. 6 (June 2006): 2072–78. http://dx.doi.org/10.1128/aac.01539-05.

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ABSTRACT Staphylococcus aureus staphylococcal cassette chromosome mec type IV (SSCmec IV) is associated with virulent community-acquired methicillin-resistant Staphylococcus aureus (MRSA) and frequent horizontal transfer among staphylococci. To gain insight into the mechanism of transfer, we studied the ccrA/B type 2 recombinase-mediated excision of SCCmec IV (n = 5 strains) and SCCmec II (n = 2). In SCCmec IV- but not SCCmec II-containing strains, spontaneous excision of the cassette was observed. Introduction of ccrA/B type 2 recombinase genes under control of an S. aureus bacterial phage promoter in the different strains yielded excision of SCCmec II and multiple excision variants of SCCmec IV. Sequencing of the alternatively excised products in SCCmec IV strains identified a 100-bp shortened SCCmec′ variant and a 5,877-bp, conserved SCC-like element that lacks mecA and ccrA/B recombinases. Excision of the SCC-like element in wild-type S. aureus was dependent on the presence of SCCmec. The element could be excised separately or as part of a novel composite cassette together with SCCmec. The relative abundance of and variety in SCCmec IV excisions may contribute to the frequency of horizontal transfer and genetic plasticity in SCCmec IV MRSA strains.

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Cabiati, Manuela, Raffaele Caruso, Alessandro Verde, Laura Sabatino, Maria-Aurora Morales, and Silvia Del Ry. "Transcriptomic Profiling of the Four Adenosine Receptors in Human Leukocytes of Heart Failure Patients." BioMed Research International 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/569438.

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In this study the transcriptomic profiling of adenosine receptors (ARs) in human leukocytes of heart failure (HF) patients as a function of clinical severity, assessing the possible changes with respect to healthy subjects (C), was evaluated. Total RNA was extracted from leukocytes ofC(n=8) and of HF patients (NYHA I-IIn=9; NYHA III-IVn=14) with a PAXgene Blood RNA Kit. An increase as a function of clinical severity was observed in each AR (A1R:C=0.02±0.009, NYHAI-II=0.21±0.09, NYHAIII-IV=3.6±1.3,P=0.03 Cversus NYHA III-IV,P=0.02NYHA I-II versus NYHA III-IV; A2aR:C=0.2±0.05, NYHAI-II=0.19±0.04, NYHAIII-IV=1.32±0.33,P=0.005 Cversus NYHA III-IV,P=0.003NYHA I-II versus NYHA III-IV; A2bR:C=1.78±0.36, NYHAI-II=1.35±0.29, NYHAIII-IV=4.07±1.21,P=0.03: NYHA I-II versus NYHA III-IV; A3R:C=0.76±0.21, NYHAI-II=0.94±0.19, NYHAIII-IV=3.14±0.77,P=0.01 Cversus NYHA III-IV and NYHA I-II versus NYHA III-IV, resp.). The mRNA expression of the ectonucleoside triphosphate diphosphohydrolase (CD39) and the ecto-5′-nucleotidase (CD73) were also evaluated. They resulted up-regulated. These findings show that components of adenosine metabolism and signalling are altered to promote adenosine production and signalling in HF patients. Thus, HF may benefit from adenosine-based drug therapy after confirmation by clinical trials.

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Smith, Graham, and Daniel E. Lynch. "Crystal structures and hydrogen bonding in the morpholinium salts of four phenoxyacetic acid analogues." Acta Crystallographica Section E Crystallographic Communications 71, no. 11 (October 28, 2015): 1392–96. http://dx.doi.org/10.1107/s2056989015019842.

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The anhydrous salts morpholinium (tetrahydro-2-H-1,4-oxazin-4-ium) phenoxyacetate, C4H10NO+·C8H7O3−, (I), morpholinium (4-fluorophenoxy)acetate, C4H10NO+·C8H6 FO3−, (II), and isomeric morpholinium (3,5-dichlorophenoxy)acetate (3,5-D), (III), and morpholinium (2,4-dichlorophenoxy)acetic acid (2,4-D), C4H10NO+·C8H5Cl2O3−, (IV), have been determined and their hydrogen-bonded structures are described. In the crystals of (I), (III) and (IV), one of the the aminium H atoms is involved in a three-centre asymmetric cation–anion N—H...O,O′R12(4) hydrogen-bonding interaction with the two carboxyl O-atom acceptors of the anion. With the structure of (II), the primary N—H...O interaction is linear. In the structures of (I), (II) and (III), the second N—H...Ocarboxylhydrogen bond generates one-dimensional chain structures extending in all cases along [100]. With (IV), the ion pairs are linked though inversion-related N—H...O hydrogen bonds [graph setR42(8)], giving a cyclic heterotetrameric structure.

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Radhakrishnan, N., R. Roy, A. Thomas, B. Mehrotra, and U. Iqbal. "Long-term outcome of penile cancer: Single North American institutional study." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 15645. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.15645.

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15645 Background: Penile cancer is a rare malignancy in the Western world with limited published data. We conducted a review of patient (pt.) records diagnosed with penile cancer at our instituition to evaluate the patterns of treatment, responses, recurrences and long term outcomes. Methods: IRB approval was obtained for this retrospective analysis. Tumor registry data was analysed for all adult patients diagnosed with penile cancers between 1995 and 2005. Patient characteristics including age, disease stage, histology, grade, ethnicity, treatment modalities and outcomes were recorded. Results: 24 pts were identified. Median age: 68 years (range: 38 - 86), Stage distribution: Stage 0 (n=7, 29%), Stage I: n =8 (33.%) ; Stage II: n= 4 (17%); Stage III: n = 1 (4%), Stage IV: n=4 (16.7%); ethnicity: Caucasian:17, African-American: n=3; Hispanic: n=1;and South Asian: n=6; Histology: squamous (sq.): n = 21(88%), sq. with sarcomatoid features: n=1(4%), small cell ca: n = 1, (4%); poorly diff. ca: n = 1 (4%). Grades 1,2,3 in each stage respectively : stage I: ( n= 4, 2, 1), stage II: (n = 0,1,2), stage III: (1,0,0), stage IV: (n = 1,2,1). Treatment and Outcome: All pts with stage 0 disease were treated with excision biopsy. 3 of 7 (40%) recurred but are disease free after re-excision. All pts with Stage I disease were treated with partial penectomy. Two of 8 (25%) recurred, of which one pt died of his disease. All pts with stage II were treated with surgery (penectomy) and CT. One pt was additionally treated with RT to the groin. Except for this pt all stage II pts recurred and died due to recurrent disease. The pt with stage III disease was treated with a partial penectomy and CT and remains disease free without recurrence. All pts with stage IV disease were treated with CT, 3 were also treated with RT , but all died of metastatic disease. Median OS: Stage 0: 70+ mo, (20–150 ); Stage I: 69 mo (11–133); Stage II: 25 mo(12–84); Stage III: 25 mo; Stage IV: 7 mo ( 7- 23); Conclusions: Pts with early stage 0 and I disease have a high local recurrence rate (33%) but are curable with surgical salvage. Stages II, III and IV pts have high recurrence rates and poor prognoses despite treatment with penectomy and CT. Future trials should address the benefit of adjuvant chemo/RT in patients with intermediate stage (II & III) disease. No significant financial relationships to disclose.

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Kleiber, Tomasz. "Effect of Manganese Nutrition on Content of Nutrient and Yield of Lettuce (Lactuca Sativa L.) in Hydroponic/Wpływ Żywienia Manganem Na Zawartość Składników I Plonowanie Sałaty (Lactuca Sativa L.) W Hydroponice." Ecological Chemistry and Engineering S 21, no. 3 (October 1, 2014): 529–37. http://dx.doi.org/10.2478/eces-2014-0039.

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Abstract The aim of conducted studies was estimation of increase manganese nutrition on content of nutrient and yielding of lettuce (Lactuca sativa L.) in hydroponic cultivation. Plants were grown in rockwool using closed system fertigation with recirculation of nutrient solution. In experiment were used nutrient solution with following nutrient contents [mg·dm-3]: N-NH4 < 10, N-NO3 150, P-PO4 50, K 150, Ca 150, Mg 50, Fe 3.00, Zn 0.44, Cu 0.03, B 0.011, pH 5.50, EC 1.8 mS·cm-1. It was studied the following manganese concentrations in nutrient solution (in [mg・dm-3]): 0.5, 4.8, 9.6, 19.2 (described as Mn-I, Mn-II, Mn-III and Mn-IV). It was found a significant influence of increasing manganese concentration applied in fertigation on the content of: N, K (for Mn-IV); P, Fe, Cu (for Mn-III and Mn-IV); Mg, Zn (for Mn-II to Mn-IV) in aboveground parts of lettuce. It was no differences in case of calcium and sodium content. Increasing concentration of manganese used to fertigation significantly influenced the content of Mn in plants. Manganese also affected on the SPAD measurement (decreasing at Mn-IV) and yielding of the plants (decreasing for Mn-II to Mn-IV comparing with Mn-I).

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Gracza, Tibor, Zdeněk Arnold, and Jaroslav Kováč. "Reaction of vinamidinium salts of furan with aldehydes." Collection of Czechoslovak Chemical Communications 50, no. 3 (1985): 675–82. http://dx.doi.org/10.1135/cccc19850675.

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5-(N,N-dimethylamino)-2-furfurylidene-N,N-dimethylimmonium bromide(I) reacts with aromatic aldehydes and its vinylogues to give condensation products II. Addition of alkoxides, sulfinates or thiolates to II renews the furan ring what can be utilized for preparation of new 4-(Ar-, R-methyl)-5-(N,N-dimethylamino)-2-furancarbaldehydes IV.

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Panchal, Janak, Ravindra Jadav, Vipul Solanki, Sachin Kalaswa, Keshav, and B. N. Suthar. "Evaluation and Comparison of Therapeutic Efficacy of Various Hormonal Protocols in Anoestrus Buffalo Heifers of Semi-Arid Region." Annual Research & Review in Biology 39, no. 4 (April 11, 2024): 54–60. http://dx.doi.org/10.9734/arrb/2024/v39i42075.

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To assess and compare different hormonal protocols' treatment efficacy in anoestrus buffalo heifers in a semi-arid region. Forty buffalo heifers with a history of anoestrus were chosen randomly from the semi-arid region of Banaskanth and divided into four equal groups.Group-I: Heatsynch protocol (n = 10), Group-II Ovsynch protocol (n = 10), Group-III Doublesynch protocol (n = 10) and Group-IV Control (n = 10) are followed by artificial insemination at a predetermined period in treated buffalo heifers and insemination during spontaneous estrus in group-IV buffalo heifers. In Groups I, II, and III, the corresponding percentages of estrus induction were 90, 80, and 80 percent. Major symptoms such as edoema, erythema, dampness of vulva and estrus mucus secretion were present during the expression of estrus. Fifty percent of the buffalo heifers in Group IV displayed estrus at varying intervals. After three consecution services, Group II had the highest overall fertility rate (50%) followed by Group III (40%), Group I (30%), and Group IV (30%). In true anoestrus buffalo heifers, the Heatsynch, Ovsynch, and Doublesynch procedure can be applied with success to induce estrus. Buffalo heifers that follow the Ovsynch protocol may have a higher conception rate.

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Kakanejadifard, Ali, Abedien Zabardasti, Motaleb Ghasemian, and Esmaiel Niknam. "Complexation of (1Z, 2Z)- N ′-1-, N ′-2-dihydroxy- N -1-, N -2-dipyridin-2-ylethanedimidamide in mono and dinuclear Zn(II), Cd(II), Hg(II) and Sn(IV) complexes." Journal of Coordination Chemistry 61, no. 11 (June 4, 2008): 1820–26. http://dx.doi.org/10.1080/00958970701621217.

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Cabezas-Camarero, Santiago, Vanesa García-Barberán, Rebeca Pérez-Alfayate, María L. Gandía, Isabel Díaz-Millán, and Pedro Pérez-Segura. "Plasma PD-L1 levels according to histologic grade and IDH status in patients with gliomas." Journal of Clinical Oncology 38, no. 5_suppl (February 10, 2020): 69. http://dx.doi.org/10.1200/jco.2020.38.5_suppl.69.

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69 Background: Plasma immune biomarkers such as soluble plasma PD-L1 (sPD-L1) may serve as surrogates of the immune condition of cancer patients and be potential markers of response to different immunotherapy modalities. Very few data exist regarding sPD-L1 in patients with primary brain tumors. Our aim was to study the levels of sPD-L1 in patients with gliomas according to histologic grade and IDH mutation status. Methods: Patients (pts) with grade II to IV gliomas were prospectively enrolled. Single-time-point plasma samples were obtained prior to adjuvant radiotherapy +/- chemotherapy. sPD-L1 determined using ELISA with a rabbit polyclonal anti-PDL1/CD274 antibody as capture reagent. Results: Between February 2017 and August 2019, 44 patients (pts) with gliomas and 12 healthy controls (HC) were enrolled. N=11 grade II, n=9 grade III, n=24 grade IV; n=26 IDHwt, n=18 IDHmut. Higher sPD-L1 levels in glioma pts compared to HC (60.8 vs 47.8 ng/ml, p=0.05). Higher sPD-L1 levels in grade II vs grades III-IV (73.3 vs 60 ng/ml, p=0.09). Higher sPD-L1 in IDHmut grades II-III vs IDHwt grades II-III + IDHmut/wt grade IV (73 vs 59 ng/ml, p=0.07). Non-significantly higher sPD-L1 in grades II-III vs grade IV (73 vs 59 ng/ml, p=0.46). No difference in sPD-L1 in IDHmut vs IDHwt (63.3 vs 59.1 ng/ml, p=0.496), nor in IDHwt vs HC (59.1 vs 47.8 ng/ml, p=0.109). Trend to significance in IDHmut vs HC (63.3 vs 47.8, p=0.062). Conclusions: sPD-L1 levels were significantly higher in glioma pts compared to HC. A trend was seen towards higher sPD-L1 levels in lower-grade (grades II, III) IDHmut gliomas. These findings may indicate a different systemic immune profile for currently defined glioma groups based on histologic grade and IDH status and merit confirmation in a larger sample.

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Sevinçek, Resul, Duygu Barut Celepci, Serap Köktaş Koca, Özlem Akgül, and Muittin Aygün. "Substituent position effect on the crystal structures of N-phenyl-2-phthalimidoethanesulfonamide derivatives." Acta Crystallographica Section C Structural Chemistry 74, no. 1 (January 1, 2018): 31–36. http://dx.doi.org/10.1107/s2053229617017442.

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In order to determine the impact of different substituents and their positions on intermolecular interactions and ultimately on the crystal packing, unsubstituted N-phenyl-2-phthalimidoethanesulfonamide, C16H14N2O4S, (I), and the N-(4-nitrophenyl)-, C16H13N3O6S, (II), N-(4-methoxyphenyl)-, C16H16N3O6S, (III), and N-(2-ethylphenyl)-, as the monohydrate, C18H18N2O4S·H2O, (IV), derivatives have been characterized by single-crystal X-ray crystallography. Sulfonamides (I) and (II) have triclinic crystal systems, while (III) and (IV) are monoclinic. Although the molecules differ from each other only with respect to small substituents and their positions, they crystallized in different space groups as a result of differing intra- and intermolecular hydrogen-bond interactions. The structures of (I), (II) and (III) are stabilized by intermolecular N—H...O and C—H...O hydrogen bonds, while that of (IV) is stabilized by intermolecular O—H...O and C—H...O hydrogen bonds. All four structures are of interest with respect to their biological activities and have been studied as part of a program to develop anticonvulsant drugs for the treatment of epilepsy.

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Smith, Graham, and Daniel E. Lynch. "Cyclic heterotetrameric and low-dimensional hydrogen-bonded polymeric structures in the morpholinium salts of ring-substituted benzoic acid analogues." Acta Crystallographica Section C Structural Chemistry 72, no. 2 (January 14, 2016): 105–11. http://dx.doi.org/10.1107/s2053229615024821.

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The morpholinium (tetrahydro-2H-1,4-oxazin-4-ium) cation has been used as a counter-ion in both inorganic and organic salt formation and particularly in metal complex stabilization. To examine the influence of interactive substituent groups in the aromatic rings of benzoic acids upon secondary structure generation, the anhydrous salts of morpholine with salicylic acid, C4H10NO+·C7H5O3−, (I), 3,5-dinitrosalicylic acid, C4H10NO+·C7H3N2O7−, (II), 3,5-dinitrobenzoic acid, C4H10NO+·C7H3N2O6−, (III), and 4-nitroanthranilic acid, C4H10NO+·C7H5N2O4−, (IV), have been prepared and their hydrogen-bonded crystal structures are described. In the crystal structures of (I), (III) and (IV), the cations and anions are linked by moderately strong N—H...Ocarboxylhydrogen bonds, but the secondary structure propagation differs among the three,viz.one-dimensional chains extending along [010] in (I), a discrete cyclic heterotetramer in (III), and in (IV), a heterotetramer with amine N—H...O hydrogen-bond extensions alongb, giving a two-layered ribbon structure. With the heterotetramers in both (III) and (IV), the ion pairs are linked though inversion-related N—H...Ocarboxylatehydrogen bonds, giving cyclicR44(12) motifs. With (II), in which the anion is a phenolate rather than a carboxylate, the stronger assocation is through a symmetric lateral three-centre cyclicR12(6) N—H...(O,O′) hydrogen-bonding linkage involving the phenolate and nitro O-atom acceptors of the anion, with extension through a weaker O—H...Ocarboxylhydrogen bond. This results in a one-dimensional chain structure extending along [100]. In the structures of two of the salts [i.e.(II) and (IV)], there are also π–π ring interactions, with ring-centroid separations of 3.5516 (9) and 3.7700 (9) Å in (II), and 3.7340 (9) Å in (IV).

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Sabbaghi, Fahimeh, Azam As'habi, Anahid Saneei, Mehrdad Pourayoubi, Abdul Ajees Abdul Salam, Marek Nečas, Michal Dušek, Monika Kučeráková, and Sudarshan Acharya. "Conformational analysis of two new organotin(IV) structures completed with a CSD survey." Acta Crystallographica Section C Structural Chemistry 77, no. 2 (January 8, 2021): 68–80. http://dx.doi.org/10.1107/s2053229620016502.

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The conformational flexibilities are studied in two new organotin(IV) complexes, namely, trans-dichloridodimethylbis[N,N′,N′′-tris(2-chlorobenzyl)phosphoric triamide]tin(IV), [Sn(CH3)2(C21H21Cl3N3OP)2Cl2] or Sn(CH3)2Cl2{OP[NHCH2C6H4(2-Cl)]3}2, (I), and bis(dipropylammonium) tetrachloridodimethylstannate(IV), [(CH3CH2CH2)2NH2]2[Sn(CH3)2Cl4], (II), and their analogous structures from the Cambridge Structural Database (CSD). The conformations are considered based on the N—P=O—Sn torsion angles for (I) and the C—C—C—N, C—C—N—C, C—N—C—C and N—C—C—C torsion angles for the two symmetry-independent [CH3CH2CH2NH2CH2CH2CH3]+ cations in (II), and the ±ac±sp±ac (ac = anticlinal and sp = synperiplanar) and ±ap±ap±ap±ap (ap = antiperiplanar) conformations are observed, respectively. In both structures, the four atoms in the corners of the square-planar segment of the octahedral shape around the Sn atom participate in normal hydrogen-bonding interactions as acceptors, which include two O and two Cl atoms for (I), and four Cl atoms for (II). However, the phosphoric triamide ligands block the environment around the Sn atom and limit the hydrogen-bond pattern to form a supramolecular ribbon assembly, while in the presence of small organic cations in (II), a two-dimensional hydrogen-bonded architecture is achieved. The weak interactions π–π, C—H...π and C—Cl...π in (I), and C—H...Cl in (II) do not change the dimensionality of the hydrogen-bond pattern. The 62 CSD structures analogous to (I), i.e. with an SnOPN3 segment (including 83 entries) fall into four categories of conformations based on the N—P=O—Sn torsion angles. The 132 [(CH3CH2CH2)2NH2]+ cations from 85 CSD structures are classified into seven groups based on the torsion angles noted for (II). Most of the CSD structures adopt the same associated conformations noted for (I) and (II). 15 [Sn(CH3)2Cl4]2− anions extracted from the CSD are compared with the structure of (II).

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Dahry, Sundahry, Nurlev Avana, Aprizan A, and Jumiyatun J. "PENINGKATAN PROSES DAN HASIL BELAJAR MATEMATIKA MENGGUNAKAN METODE COURSE REVIEW HORAY (CRH) DI KELAS IV SD N 65/II SUNGAI BANGSAT KECAMATAN PELEPAT." Jurnal Inovasi Pendidikan dan Teknologi Informasi (JIPTI) 1, no. 2 (September 13, 2020): 49–55. http://dx.doi.org/10.52060/pti.v1i2.358.

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Penelitian ini di latar belakangi oleh rendahnya hasil belajar matematika di kelas IV SD N 65/II Sungai Bangsat. Tujuan dilakukannya penelitian ini adalah untuk mendeskripsikan peningkatkan proses dan hasil belajar matematika menggunakan metode Course Review Horay (CRH) di kelas IV SD N 65/II Sungai Bangsat. Penelitian ini merupakan jenis Penelitian Tindakan Kelas yang dilaksanakan dengan dua siklus masing-masing siklus terdiri dari dua kali pertemuan. Setiap siklusnya terdiri dari perencanaan, pelaksanaan, pengamatan, dan refleksi. Hasil analisis data menunjukkan bahwa penggunaan metode Course Review Horay (CRH) dapat meningkatkan proses dan hasil belajar matematika siswa kelas IV SD N 65/II Sungai Bangsat. Rincian hasil observasi guru pada siklus I dengan rata-rata aktivitas guru sebesar 96,99, pada siklus II rata-rata aktivitas guru sama yaitu 96,99 dengan kategori sangat baik. Hasil observasi siswa siklus I data analisis aktivitas siswa sebesar 62,94% dengan kriteria baik, meningkat menjadi 86,35% pada siklus II dengan kriteria sangat baik. pada siklus I diperoleh nilai rata-rata hasil belajar siswa sebesar 83,63 meningkat menjadi 96,36 pada siklus II. Sedangkan ketuntasan klasikal pada siklus I sebesar 86,36%, meningkat menjadi 95,45% pada siklus II. Disimpulkan bahwa penggunaan metode Course Review Horay (CRH) dapat meningkatkan proses dan hasil belajar matematika.

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Kimberly, W. Taylor, Matthew B. Bevers, Rüdiger von Kummer, Andrew M. Demchuk, Javier M. Romero, Jordan J. Elm, Holly E. Hinson, Bradley J. Molyneaux, J. Marc Simard, and Kevin N. Sheth. "Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial." Neurology 91, no. 23 (November 16, 2018): e2163-e2169. http://dx.doi.org/10.1212/wnl.0000000000006618.

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ObjectiveIn this secondary analysis of the Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial, we report the effect of IV glyburide on adjudicated, edema-related endpoints.MethodsBlinded adjudicators assigned designations for hemorrhagic transformation, neurologic deterioration, malignant edema, and edema-related death to patients from the GAMES-RP phase II randomized controlled trial of IV glyburide for large hemispheric infarct. Rates of these endpoints were compared between treatment arms in the per-protocol sample. In those participants with malignant edema, the effects of treatment on additional markers of edema and clinical deterioration were examined.ResultsIn the per-protocol sample, 41 patients received glyburide and 36 received placebo. There was no difference in the frequency of hemorrhagic transformation (n = 24 [58.5%] in IV glyburide vs n = 23 [63.9%] in placebo, p = 0.91) or the incidence of malignant edema (n = 19 [46%] in IV glyburide vs n = 17 [47%] in placebo, p = 0.94). However, treatment with IV glyburide was associated with a reduced proportion of deaths attributed to cerebral edema (n = 1 [2.4%] with IV glyburide vs n = 8 [22.2%] with placebo, p = 0.01). In the subset of patients with malignant edema, those treated with IV glyburide had less midline shift (p < 0.01) and reduced MMP-9 (matrix metalloproteinase 9) levels (p < 0.01). The glyburide treatment group had lower rate of NIH Stroke Scale (NIHSS) increase of ≥4 during the infusion period (n = 7 [37%] in IV glyburide vs n = 12 [71%] in placebo, p = 0.043), and of change in level of alertness (NIHSS subscore 1a; n = 11 [58%] vs n = 15 [94%], p = 0.016).ConclusionIV glyburide was associated with improvements in midline shift, level of alertness, and NIHSS, and there were fewer deaths attributed to edema. Additional studies of IV glyburide in large hemispheric infarction are warranted to corroborate these findings.ClinicalTrials.gov identifierNCT01794182.Level of evidenceThis study provides Class II evidence that for patients with large hemispheric infarction, IV glyburide improves some edema-related endpoints.

Journal articles on the topic 'II-IV-N₂'

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