Academic literature on the topic 'Ignatosky'

Atherosclerosis is the main cause of cardiovascular diseases, which, despite a number of new advances in their diagnosis and treatment, still occupy a leading position. Experimental modeling of atherosclerosis in laboratory animals plays an important role in the study of the fundamental pathophysiological processes and pathology of atherosclerosis. Rabbits are among the most suitable animals for simulating atherosclerosis, as they are widely available, inexpensive to maintain, and easy to manipulate. The key advantage of rabbits over other animals is that their lipid metabolism is practically similar to that of humans. The aim of the study was to analyze literature data on experimental models of atherosclerosis in rabbits. The review shows that the history of the study of atherosclerosis by means of experimental models is very rich and originates from the works of the well-known Russian pathologists A.I. Ignatovsky, N.N. Anichkov, S.S. Khalatov (1908-1915), who developed a cholesterol model of the formation of atherosclerosis in rabbits. The principle of this model is to feed laboratory animals with food containing elevated levels of lipids and cholesterol. The composition of the cholesterol (atherogenic) diet may vary, determining the existence of modifications of this model. Most often, a diet with a cholesterol content of 0.3-0.5% is used, in cases where it is necessary to accelerate the development of atherosclerosis, a short-term use of a diet with a 1% cholesterol content is allowed. In addition to cholesterol, it is recommended to use vegetable oils (soybean, coconut or corn) in the atherogenic diet as they improve the absorption of cholesterol in the intestine. In 1980, Japanese researcher Y. Watanabe deduced a new model of atherosclerosis formation - on hereditarily determined hyperlipidemic rabbits Watanabe (WHHL-rabbits). WHHL rabbits contain a genetic mutation in the gene encoding low-density lipoprotein receptors, which results in these animals having high plasma cholesterol levels with a normal diet. Thanks to modern genetic technologies, various genetic models of atherosclerosis in rabbits have also been created: transgenic and “knocked out” rabbits. The main method for obtaining transgenic rabbits is pronuclear microinjection, which allows the introduction of a transgene (additional DNA fragment) into their genome. To date, using this technology, it has been possible to introduce more than a dozen genes responsible for lipid metabolism. The principle of creating knocked out rabbits consists in specific inactivation using genome editing technologies (ZFN, TALEN, CRISPR / Cas9) of a certain working gene. Experimental models of atherosclerosis in rabbits have not lost their significance and continue to be used to study the fundamental morphological (pathological) and pathological mechanisms underlying atherosclerosis, to search for new diagnostic biomarkers and potential targets for therapeutic effects, as well as to conduct preclinical trials of newly developed drugs.

The scientific activity of academicians of the first composition of the Belarusian Academy of Sciences in the field of studying the history and culture of Belarus is considered. Particular attention is paid to works on the history of typography, the authors of which are famous scholars: historians Vladimir Picheta, Vaclav Lastovsky, Vasily Ignatovsky, linguist Stepan Nekrashevich.

AbstractEarly concepts of the origin of arteriosclerosis were introduced in the 19th century by Rokitansky and Virchow, who described mural thrombosis, inflammatory damage to arterial intima, increased intimal permeability to plasma, mucoid degeneration of arterial wall, deposition of plasma lipids in plaques, and fibrosis and calcification of plaques. Experimental production of arteriosclerosis by feeding animal foods to rabbits was attributed to protein intoxication by Ignatowsky in 1908 and to dietary cholesterol by Anitschkow in 1913. Newburgh confirmed the protein hypothesis in 1915–1925 but failed to identify which amino acid produced plaques because methionine (1922) and homocysteine (1932) had not yet been discovered. Cases of homocystinuria from inherited deficiency of cystathionine synthase were found to be associated with thrombosis and vascular disease in 1964. The index case of methionine synthase deficiency (cobalamin C disease) was found by McCully in 1969 to be associated with arteriosclerosis, leading to the homocysteine theory of arteriosclerosis. The theory explains experimental arteriosclerosis by deficiency of vitamin B

Almost immediately after the seminal papers of Poincaré (1905,1906) and Einstein (1905) on special relativity, wherein Poincaré established the full covariance of the Maxwell-Lorentz equations under the scale-extended Poincaré group and Einstein explained the Lorentz transformation using his assumption that the one-way speed of light in vacuo is constant and the same for all inertial observers (Einstein’s second postulate), attempts were made to get at the Lorentz transformations from basic properties of space and time but avoiding Einstein’s second postulate. Various such approaches usually involve general consequences of the relativity principle, such as a group structure to the set of all admissible inertial transformations and also assumptions about causality and/or homogeneity of space-time combined with isotropy of space. The first such attempt is usually attributed to von Ignatowsky in 1911. It was followed shortly thereafter by a paper of Frank and Rothe published in the same year. Since then, papers have continued to be written on the subject even up to the present. We elaborate on some of the results of such papers paying special attention to a 1968 paper of Bacri and Lévy-Leblond where possible kinematical groups include the de Sitter and anti-de Sitter groups and lead to special relativity in de Sitter and anti-de Sitter spaces.

AbstractIn 1909, Ehrenfest published a note in the Physikalische Zeitschrift showing that a Born rigid cylinder could not be set into rotation without stresses, as elements of the circumference would be contracted but not the radius. Ignatowski and Varićak challenged Ehrenfest’s result in the same journal, arguing that the stresses would emerge if length contraction were a real dynamical effect, as in Lorentz’s theory. However, no stresses are expected to arise, according to Einstein’s theory, where length contraction is only an apparent effect due to an arbitrary choice of clock synchronization. Ehrenfest and Einstein considered this line of reasoning dangerously misleading and took a public stance in the Physikalische Zeitschrift, countering that relativistic length contraction is both apparent and real. It is apparent since it disappears for the comoving observer, but it is also real since it can be experimentally verified. By drawing on his lesser-known private correspondence with Varićak, this paper shows how Einstein used the Ehrenfest paradox as a tool for an ‘Einsteinian pedagogy’. Einstein’s argumentative stance is contrasted with Bell’s use of the Dewan-Beran thread-between-spaceships paradox to advocate for a ‘Lorentzian pedagogy’. The paper concludes that the disagreement between the two ways of ‘teaching special relativity’ stems from divergent interpretations of philosophical categories such as ‘reality’ and ‘appearance’.