Relevant bibliographies by topics / IgA Vasculitis

Academic literature on the topic 'IgA Vasculitis'

Author: Grafiati
Published: 25 July 2024
Last updated: 31 July 2024

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Journal articles on the topic "IgA Vasculitis"

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Sugino, Hitomi, Yu Sawada, and Motonobu Nakamura. "IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes." International Journal of Molecular Sciences 22, no. 14 (July 14, 2021): 7538. http://dx.doi.org/10.3390/ijms22147538.

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IgA, previously called Henoch-Schönlein vasculitis, is an essential immune component that drives the host immune response to the external environment. As IgA has the unique characteristic of a flexible response to broad types of microorganisms, it sometimes causes an autoreactive response in the host human body. IgA vasculitis and related organ dysfunction are representative IgA-mediated autoimmune diseases; bacterial and viral infections often trigger IgA vasculitis. Recent drug developments and the presence of COVID-19 have revealed that these agents can also trigger IgA vasculitis. These findings provide a novel understanding of the pathogenesis of IgA vasculitis. In this review, we focus on the characteristics of IgA and symptoms of IgA vasculitis and other organ dysfunction. We also mention the therapeutic approach, biomarkers, novel triggers for IgA vasculitis, and epigenetic modifications in patients with IgA vasculitis.
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Sotoodian, Bahman, Janet Robert, Muhammad N. Mahmood, and Elaine Yacyshyn. "IgA Cutaneous Purpura Post–Renal Transplantation in a Patient With Long-Standing IgA Nephropathy." Journal of Cutaneous Medicine and Surgery 19, no. 5 (April 15, 2015): 498–503. http://dx.doi.org/10.1177/1203475415582135.

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Background: IgA vasculitis is a small-vessel vasculitis caused by deposition of IgA antibodies in tissues. IgA nephropathy and IgAV have long been considered related conditions. Objective: To assess the prevalence and implications of new-onset Henoch-Schönlein purpura (HSP) after renal transplant in patients with underlying IgA nephropathy. Methods: The PubMed database was searched for keywords such as IgAV, IgA vasculitis, Henoch-Schönlein purpura, HSP, IgA nephropathy, and renal transplant. Results: Two cases of new-onset IgA vasculitis post–renal transplant after stopping the prednisone or receiving seasonal influenza vaccine have been reported. We report the case of new-onset IgA cutaneous vasculitis in a renal transplant patient with IgA nephropathy after reduction in his prednisone dosage. Conclusion: The new development of cutaneous IgA vasculitis is unusual in renal transplant patients with IgA nephropathy. Despite these patients’ being immunosuppressed, the presence of IgA vasculitis could signal the recurrence of IgA nephropathy.
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Levanon, S., V. Gotlieb, Y. Kraus, I. Novofastovski, S. Brikman, A. Fawaz, M. Aghbariyya, et al. "POS0831 IgA VASCULITIS IN ADULTS, PEDIATRICS AND NON-VASCULITIC IgA NEPHROPATHY." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 706.2–707. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3368.

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BackgroundIgA vasculitis (IgAV) has been extensively studied in children, while its natural history remains poorly studied in adults. Sparse data comparing childhood and adult-onset disease has shown significant differences in their clinical presentation, especially in the severity of renal involvement, which accounts for the major long-term morbidity. IgAV shares similar renal histologic features with IgA nephropathy (IgAN), while clinically IgAN is a chronic kidney disease which may lead to end stage renal disease and dialysis. The extent of kidney injury among adults with IgAV is still a matter of uncertainty.ObjectivesWe aimed to evaluate clinical manifestations, laboratory data, treatment patterns and long-term outcomes of pediatric and adult-onset IgAV in comparison to IgAN.MethodsThis retrospective collaborative study examined medical records of adults and children with IgAV and IgAN adult patients admitted to rheumatology clinic and in hospital pediatric departments in a 13-year period (2007-2019). Diagnosis of adults with IgAV relied on the Ankara criteria and was confirmed by a consistent skin biopsy with positive IgA staining by immunofluorescence. Children with IgAV were included in our study on a clinical basis. All IgAN patients had a kidney biopsy proven disease. We analyzed and compared frequencies of clinical manifestations, laboratory findings, treatment regimens and long-term outcomes at one year follow-up. Finally, we assessed long term outcomes, such as time to dialysis and all-cause mortality, till the end of the follow-up time.ResultsA total of 60 adult IgAV, 60 pediatric IgAV and 45 IgAN patients were included in our study. There were significantly more males in the IgAN group compared to the adult and pediatric IgAV groups (77.8%, 41.7% and 55% respectively, p=0.01). Adult IgAV patients were significantly older than IgAN patients (53.1±17.4 years vs. 45.1±15.7 years, p=0.02) and had significantly higher rates of diabetes (43.3% vs. 24.4%, p=0.05) and ischemic heart disease (18.3% vs. 4.4%, p=0.03). The pediatric IgAV group had a statistically higher rate of previous infection compared to the adult IgAV group (44.8% vs. 20%, p=0.02). At one year follow-up, IgAN patients had higher levels of serum creatinine compared to the adult IgAV group (2.002 vs. 1.100, p<0.01). Data observed until the end of the follow-up time showed no difference in time to dialysis (IgAV adults: 9.8-12.4 years, IgAN: 5.0-6.6 years, p>.41). Nevertheless, IgAV adult patients had significantly shorter survival time (5.5 years, 95% CI: 4.8-6.2 years) than IgAN patients (7.0 years, 95% CI: 6.6-7.5 years, p<.01).ConclusionThis retrospective study demonstrates that IgAV in adults presents substantial clinical manifestations, including high risk of progression to persistent renal impairment and possesses higher mortality rate in comparison with pediatric-onset disease and IgAN.References[1]Blanco R, Martínez-Taboada VM, Rodríguez-Valverde V, García-Fuentes M, González-Gay MA. Henoch-Schönlein purpura in adulthood and childhood: two different expressions of the same syndrome. Arthritis Rheum. 1997 May;40(5):859-64. doi: 10.1002/art.1780400513. PMID: 9153547.[2]Nossent J, Raymond W, Isobel Keen H, Preen D, Inderjeeth C. Morbidity and mortality in adult-onset IgA vasculitis: a long-term population-based cohort study. Rheumatology (Oxford). 2021 Dec 24;61(1):291-298. doi: 10.1093/rheumatology/keab312. PMID: 33779729.Figure 1.Disclosure of InterestsNone declared
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Marro, Julien, Andrew J. Chetwynd, Samuel Edwards, Rachael D. Wright, and Louise Oni. "Increased Urinary IgA in Paediatric IgA Vasculitis Nephritis." International Journal of Molecular Sciences 23, no. 23 (November 22, 2022): 14548. http://dx.doi.org/10.3390/ijms232314548.

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IgA vasculitis (IgAV) is the most common form of paediatric vasculitis, with up to 50% of patients experiencing kidney inflammation. Much remains unknown about IgAV, but it is believed to arise due to galactose-deficient IgA1 promoting an auto-inflammatory response. This study assesses whether urinary IgA can be detected in children with IgAV to allow further evaluation of IgA1 and whether it has any relationship with nephritis. Urinary and serum IgA concentrations were measured using commercially available ELISA kits. Patients were grouped into IgAV nephritis (IgAVN) or IgAV without nephritis (IgAVwoN). Fifty-nine children were included: IgAVN n = 12, IgAVwoN n = 35, and healthy controls (HC) n = 12, with a mean age of 8.2 ± 4.1 years. Urinary IgA concentrations were statistically significantly higher in patients with IgAV (107.1 ± 136.3 μg/mmol) compared to HC (50.6 ± 26.3 μg/mmol; p = 0.027) and IgAVN (229.8 ± 226.3 μg/mmol) compared to both IgAVwoN (65.0 ± 37.8 μg/mmol; p = 0.002) and HC (p < 0.001). Urinary IgA concentrations were able to distinguish between renal status (AUC 0.838, 95%CI [0.704–0.973], p < 0.001) and did not correlate with proteinuria (r = 0.124; p = 0.407). Urinary IgA concentrations are increased in children with IgAVN, and it has the potential to act as a non-invasive biofluid to further evaluate nephritis in this disease.
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Nüsken, Eva, and Lutz T. Weber. "IgA vasculitis nephritis." Current Opinion in Pediatrics 34, no. 2 (February 7, 2022): 209–16. http://dx.doi.org/10.1097/mop.0000000000001120.

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Ozen, Seza, and Erdal Sag. "Childhood vasculitis." Rheumatology 59, Supplement_3 (April 29, 2020): iii95—iii100. http://dx.doi.org/10.1093/rheumatology/kez599.

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Abstract Vasculitis is a challenging disease for paediatricians. Certain vasculitides are quite common in children whereas others are much rarer compared with adults. The most common vasculitides in childhood are IgA-associated vasculitis (Henoch–Schönlein purpura) and Kawasaki disease, which are usually self-limiting vasculitides although children do develop complications as a result. We now have much better knowledge of how to manage these patients and prevent the deleterious complications. This review provides an up-to-date discussion on childhood vasculitides, including diagnosis, treatment and follow-up strategies, together with a comparison with vasculitides in adults. It also discusses the newly defined monogenic vasculitides that often present during early childhood.
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Winkler, Clay, Raymond Dobson, and Michael Tranovich. "Low Back Pain and Swelling as an Atypical Presentation of IgA Vasculitis." Clinical Practice and Cases in Emergency Medicine 4, no. 2 (April 14, 2020): 241–43. http://dx.doi.org/10.5811/cpcem.2019.11.44574.

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Introduction: Immunoglobulin A vasculitis (IgA vasculitis), formerly Henoch-Schonlein purpura, is the most common vasculitis in children. Case Report: A 6-year-old female presented with low back pain and swelling, difficulty ambulating, and rash two weeks after a respiratory infection. She was approached with a broad differential and ultimately diagnosed with IgA vasculitis. Discussion: Cutaneous manifestations, arthralgias, renal and gastrointestinal involvement are the most common presenting signs of IgA vasculitis. Only two cases of IgA vasculitis associated with lumbar pain and swelling were identified in the literature. Conclusion: While rash and joint pain are common presenting signs of IgA vasculitis, practitioners should be aware it can present atypically.
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Tang, Mengmeng, Xue Zhang, Xueqian Li, Lei Lei, Hejia Zhang, Chen Ling, Jie Ni, Jicheng Lv, Xiaorong Liu, and Xiangmei Chen. "Serum levels of galactose-deficient IgA1 in Chinese children with IgA nephropathy, IgA vasculitis with nephritis, and IgA vasculitis." Clinical and Experimental Nephrology 25, no. 1 (September 15, 2020): 37–43. http://dx.doi.org/10.1007/s10157-020-01968-8.

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Helander, S. D., F. R. De Castro, and L. E. Gibson. "Henoch-Schönlein purpura: clinicopathologic correlation of cutaneous vascular IgA deposits and the relationship to leukocytoclastic vasculitis." Acta Dermato-Venereologica 75, no. 2 (March 1, 1995): 125–29. http://dx.doi.org/10.2340/0001555575125129.

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Significant cutaneous vascular IgA deposits are common in Henoch-Schönlein purpura but not in other vasculitides. The specificity for IgA vascular deposits for Henoch-Schönlein purpura is not well defined. To examine the specificity of IgA vascular deposits for this disease, we compared clinicopathologic features of 92 cases with IgA vascular deposits and a direct immunofluorescence impression of vasculitis with 90 similar cases without IgA deposits. Henoch-Schönlein purpura was diagnosed in 24% of cases with vascular IgA deposits on direct immunofluorescence examination. IgA deposits were frequent in erythema nodosum and venous stasis-related problems and in cryoglobulinemia, coagulopathic vasculopathies, and livedoid vasculitis. Of our cases, 78% exhibited vascular fluorescence with multiple conjugates. No histologic or immunofluorescence pattern alone was specific. The diagnostic specificity for Henoch-Schönlein purpura is improved if gastrointestinal involvement, upper respiratory infection, or age < 20 years is present. We propose diagnostic criteria for Henoch-Schönlein purpura incorporating clinical findings yielding sensitivity and specificity > 90%.
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Takeuchi, Sora, Tamihiro Kawakami, Tatsuro Okano, Haruki Shida, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu, and Takafumi Kadono. "Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis." Pathobiology 89, no. 1 (November 23, 2021): 23–28. http://dx.doi.org/10.1159/000519869.

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Introduction: IgA vasculitis is a systemic disease that results from the entrapment of circulating IgA-containing immune complexes in small-vessel walls in the skin, kidneys, and gastrointestinal tract. An excessive formation of neutrophil extracellular traps (NETs) is involved in the pathogenesis of vasculitis, especially in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This study aimed to clarify whether NETs are implicated in IgA vasculitis. Methods: Twenty-two patients with IgA vasculitis and 4 healthy volunteers were enrolled in this study. Serum levels of myeloperoxidase (MPO)-DNA complex, a fragment derived from NETs, were determined by enzyme-linked immunosorbent assay (ELISA), and the association between MPO-DNA complex levels and clinical parameters was examined. The presence of the ANCA was also assessed by ELISA specific for MPO and proteinase 3 (PR3) and indirect immunofluorescence (IIF), followed by assessing the differences in clinical parameters with and without the ANCA. Results: Serum MPO-DNA complex levels were significantly higher in patients with IgA vasculitis than those in healthy controls. A significant positive correlation between the serum MPO-DNA complex and IgA levels was noted. Interestingly, 63.6% of IgA vasculitis patients were ANCA-positive in IIF with an atypical pattern, whereas neither MPO-ANCA nor PR3-ANCA was detected by ELISA. These findings indicated that some IgA vasculitis patients possessed the so called minor ANCA. Serum IgA and MPO-DNA complex levels and the frequency of hematuria in the minor ANCA-positive group were significantly higher than in the minor ANCA-negative group. Conclusion: The collective findings suggested that NETs are certainly involved in the pathogenesis of IgA vasculitis.
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Dissertations / Theses on the topic "IgA Vasculitis"

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Piram, Maryam. "Epidémiologie de la vascularite à IgA (purpura rhumatoïde) : incidence, étiologie." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS185.

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Le purpura rhumatoïde, récemment renommé vascularite à IgA (IgAV) est, en Occident, la vascularite systémique la plus fréquente de l’enfant. Cette vascularite leucocytoclasique IgA-médiée des petits vaisseaux touche principalement la peau, les articulations, le tube digestif et les reins. L’évolution est le plus souvent favorable mais certains patients peuvent développer une pathologie rénale chronique. L’étiologie de l’IgAV étant inconnue, les études épidémiologiques sont importantes afin de générer des hypothèses étiologiques. La première partie de cette thèse consacrée à l’épidémiologie de l’IgAV, consiste en une revue de la littérature résumant l’ensemble des connaissances actuelles d’épidémiologie descriptive de l’IgAV ainsi que les facteurs de risque génétiques ou environnementaux rapportés. La seconde partie est une étude prospective sur 3 ans décrivant les caractéristiques épidémiologiques des cas incidents d’IgAV survenus chez les enfants habitant le département du Val de Marne, localisé au sud-est de Paris. Grâce à une analyse capture–recapture à 4 sources, nous avons estimé l’incidence annuelle de l’IgAV à 30/100 000 enfants < 15 ans. La faible variation de l’incidence de l’IgAV dans le temps et dans l’espace et l’existence d’une saisonnalité de la maladie suggèrent un facteur déclenchant infectieux ubiquitaire et non émergent. La troisième partie de cette thèse, s’intéresse à la question du rôle de la vaccination dans le déclenchement de l’IgAV. En l’absence d’études pharmaco-épidémiologiques robustes, nous avons réalisé une étude en case-crossover, qui est une variante d’une étude cas–témoin traditionnelle afin d’étudier l’effet de la vaccination sur le risque à court terme d’IgAV. Nos résultats indiquent que les vaccins communément réalisés chez l’enfant n’augmentent pas significativement le risque d’IgAV dans les 3 mois suivant la vaccination. Les résultats de cette thèse améliorent nos connaissances de l’épidémiologie de l’IgAV et suggèrent que les infections, mais pas les vaccins, jouent un rôle dans l’étiologie de la maladie. D’autres études épidémiologiques sont toutefois nécessaires, en particulier dans les populations non étudiées et multi-ethniques, afin de mieux cerner le rôle des facteurs génétiques dans la survenue de la maladie
Henoch-Schönlein purpura, recently renamed immunoglobulin A vasculitis (IgAV), is the most common systemic vasculitis in childhood in Western countries. The sites predominantly affected by this IgA-mediated, leukocytoclastic, small-vessel vasculitis are the skin, joints, gastrointestinal tract and kidneys. IgAV is often self-limiting, although chronic kidney disease can develop in some patients. Because the cause of IgAV is unknown, epidemiological studies are important to provide clues to understanding its etiology. The first part of this thesis, devoted to the epidemiology of IgAV, is a literature review summarizing the currently available knowledge on descriptive epidemiological aspects of IgAV and environmental and genetic risk determinants. The second part is a prospective survey describing the epidemiological characteristics of IgAV in Val de Marne, located in the southeast suburbs of Paris, France. With a 3-year study and 4-source capture–recapture analysis, we estimated the annual incidence of IgAV at 30/100,000 children (age ≤ 15 years). The few secular and geospatial variations in IgAV incidence and the observation of a seasonal pattern in IgAV incidence lend support to a role for a ubiquitous and communicable infectious trigger. The third part of the thesis addresses the concern suggested mainly by case reports of vaccination as a potential trigger of IgAV. In light of the lack of robust pharmacoepidemiological studies, we performed a case–crossover study, a variant of a traditional case–control study, to investigate the effect of vaccination on short-term risk of IgAV. The results indicated that vaccines commonly administered to children do not significantly increase the risk of IgAV in the 3 months after vaccine exposure. The results of this thesis enhance our knowledge of IgAV epidemiology and suggest that infections but not vaccines may play a role in the etiology of the disease. More epidemiological investigation is required, particularly in understudied areas and multiethnic populations, to gain insight in the burden of genetics in IgAV etiology
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Pankhurst, Tanya. "Heterogeneity of injury in vasculitis : influence of anti neutrophil cytoplasm antibody IgG subclass and endothelial susceptibility." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/718/.

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This study examined IgG subclass in ANCA associated vasculitis and glomerular endothelial cell (GEC) phenotype predisposes to injury. Using the flow model, interaction of neutrophils with normal immunoglobulin subclasses was compared to interaction with subclasses of ANCA IgG. Neutrophils were captured by normal IgG3>IgG1>IgG2/IgG4. Blockade of CD32 affected IgG3, CD16, IgG1/2. Neutrophils exposed to soluble ANCA IgG1/3 adhered to cytokine-activated endothelial cells, as did IgG4, not previously thought to bind constitutively expressed CD16/CD32. Fc blockade reduced binding. GEC were compared with human umbilical vein endothelial cells. Surface VCAM-1 was reduced on GEC and GEC demonstrated reduced leukocyte capture. RNA array analysis demonstrated a reduction in the GEC gene responsible for post translational modification of VCAM-1 to a sialoglycoprotein. VCAM-1 expression by GEC may be a protective mechanism to reduce inflammatory responses, potentially disrupted in disease. ANCA subclass and endothelial phenotype are important vasculitis pathogenesis: this may be useful in designing targeted therapy reducing overall immunsuppressive load. Additionally modification of specific adhesion molecule profiles on endothelial cells may enable alteration of conditions of one vascular bed whilst reducing impact on unaffected sites.
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Books on the topic "IgA Vasculitis"

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Lai, Kar Neng, and Sydney C. W. Tang. Immunoglobulin A nephropathy. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0066_update_001.

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Immunoglobulin A (IgA) nephropathy characteristically causes haematuria and may present as a nephritic illness in older children and young adults. However, it may occur at any age and is commonly asymptomatic, associated first with haematuria alone, later progressing in some patients to hypertension, proteinuria, and progressive loss of glomerular filtration. While this evolution is characteristically slow, over decades, in some it is rapid, leading to early end-stage renal failure. It is common for the disease to present late, as advanced renal disease, or malignant hypertension. It may present with acute kidney injury caused by crescentic disease, but acute kidney injury caused by haematuria may be confused clinically with the same. Henoch–Schönlein purpura is a type of small vessel vasculitis that is most commonly seen in children, but which occurs at all ages, that is associated with IgA deposition. In older children and most adults it merges closely into IgA nephropathy after the acute event. Outcomes in adults are less good. IgA nephropathy is the most common type of glomerulonephritis in most developed countries. The disease is more common in men, and appears to be much less common in black people. The detected incidence is strongly influenced by biopsy policies; the lower your threshold to biopsy patients with haematuria, the more of this condition you discover. There are clear genetic tendencies but the strongest risk seems to come from genes in the human leucocyte antigen complex.
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Fabrizi, Fabrizio, and Patrice Cacoub. The patient with cryoglobulinaemia. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0151.

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AbstractCryoglobulinaemia is characterized by the presence in the blood of proteins showing the that precipitate when serum is cooled. Clinically recognised cryoprecipitates are predominantly immunoglobulin-containing. In Type 1 cryoglobulinaemia, the precipitate is formed from a monoclonal paraprotein, usually IgG. In Type 2, a monoclonal IgM binds IgG to form a mixed precipitate. Type 3 cryoglobulins do not contain a monoclonal element.Type 1 cryoglobulins are a rare cause of renal disease, but cause a membranoproliferative glomerulonephritis (MPGN) with nephrotic syndrome and haematuria and usually with severe cutaneous involvement.Type 2 is most typically associated with renal disease, again characterized by MPGN and haematuria, with variable cutaneous signs and vasculitis in other organs. Many cases are associated with Hepatitis C virus (HCV) infection – but not all.Therapeutic approaches include optimal antiviral regimen, immunosuppressive therapy (corticosteroids, rituximab, and cytotoxic agents), and plasma exchange. Treatment of HCV-related mixed cryoglobulinaemia vasculitis should be adjusted according to the clinico-biological presentation.
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Lai, Kar Neng, and Sydney C. W. Tang. Immunoglobulin A nephropathy diagnosis. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0067_update_001.

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The defining histological hallmark of immunoglobulin A (IgA) nephropathy is the presence of IgA in the mesangium as the sole or dominant immunoreactant. Light microscopy appearances vary very widely. The most common appearance is mesangial cell proliferation and an increase in mesangial matrix. However, this is not diagnostic in the absence of immunohistology. Focal segmental proliferative or necrotizing glomerulonephritis may be seen in ‘vasculitic’ disease with or without the skin changes of Henoch–Schönlein purpura. Extracapillary proliferation and crescent formation may occur. Occasionally florid haematuria may cause renal failure through acute tubular injury. Most commonly the disease is slowly evolving and focal or global sclerosis and tubulointerstitial scarring develop. The Oxford classification scheme may give some prognostic weight to these changes. There are no reliable serological or urine tests for the disease. Although average levels of serum IgA are above the population average this is not diagnostically useful in individual patients. Promising biomarkers in urine and serum are under investigation.
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Book chapters on the topic "IgA Vasculitis"

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Watts, Richard A., David G. I. Scott, and Chetan Mukhtyar. "IgA Vasculitis." In Vasculitis in Clinical Practice, 127–37. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14871-7_12.

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Fenoglio, Roberta, and Dario Roccatello. "IgA Vasculitis." In Systemic Vasculitides: Current Status and Perspectives, 203–12. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40136-2_18.

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Selvaskandan, Haresh, Chee Kay Cheung, and Jonathan Barratt. "IgA Nephropathy and IgA Vasculitis." In Primer on Nephrology, 451–65. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-76419-7_24.

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Kumar, Karunesh, Jutta Köglmeier, and Keith J. Lindley. "Vasculitides Including IgA Vasculitis (Henoch–Schönlein Purpura)." In Textbook of Pediatric Gastroenterology, Hepatology and Nutrition, 431–41. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80068-0_32.

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Gupta, Pallav, and Ramesh K. Gupta. "IgA Nephropathy and IgA Vasculitis (Henoch–Schonlein Purpura)." In Pathology of Glomerular Diseases, 77–89. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-1430-0_8.

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Jennette, J. Charles. "IgA Nephropathy and IgA Vasculitis (Henoch-Schönlein Purpura)." In Fundamentals of Renal Pathology, 69–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-39080-7_6.

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Shin, Jae Il. "IgA Vasculitis Nephritis (Henoch-Schönlein Purpura Nephritis)." In Pediatric Kidney Disease, 765–82. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-11665-0_27.

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Shah, Firdosh, and Mitesh Kumar Dwivedi. "Microorganisms in Pathogenesis and Management of IgA Vasculitis and IgA Nephropathy." In Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases, 111–25. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-4800-8_5.

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Watts, Richard A. "Small vessel vasculitis." In Oxford Textbook of Medicine, edited by Richard A. Watts, 4573–79. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0461.

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Small vessel vasculitis is vasculitis affecting predominately small intraparenchymal arteries, arterioles, capillaries, and venules. There are two main types: antineutrophil cytoplasmic antibody associated and immune complex mediated. The ANCA associated vasculitides are discussed in chapter 19.3 IgA vasculitis (IgAV) was formerly known as Henoch Schönlein purpura. The revised nomenclature reflects the importance of IgA vasculitis in pathogenesis. The Chapel Hill Consensus Conference defined IgA vasculitis as ‘vasculitis with IgA1-dominant immune deposits, affecting small vessels (predominantly capillaries, venules, or arterioles)’. IgA vasculitis often involves skin and gut, and frequently causes arthritis. Glomerulonephritis indistinguishable from IgA nephropathy may occur. Its aetiology is unknown, but it frequently occurs after an infection several days to weeks before. The most frequently isolated organism is beta-haemolytic streptococcus. Drugs such as a penicillin, ampicillin, erythromycin, and non-steroidal anti-inflammatory drugs have been reported as precipitating agents. There is an association with HLA-DRB1*01 in Caucasians and there appears to be a familial association.
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Eleftheriou, Despina, and Paul A. Brogan. "Paediatric vasculitis." In Oxford Textbook of Rheumatology, 1141–52. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0136_update_001.

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Systemic vasculitis is characterized by blood vessel inflammation which may lead to tissue injury from vascular stenosis, occlusion, aneurysm, and/or rupture. Apart from relatively common vasculitides such as IgA vasculitis (Henoch–Schönlein purpura (HSP)) and Kawasaki’s disease (KD), most of the primary vasculitic syndromes are rare in childhood, but are associated with significant morbidity and mortality. New classification criteria for childhood vasculitis have recently been proposed and validated. The cause of most vasculitides is unknown, although it is likely that a complex interaction between environmental factors such as infections and inherited host responses trigger the disease and determine the vasculitis phenotype. Several genetic polymorphisms in vasculitis have now been described that may be relevant in terms of disease predisposition or development of disease complications. Treatment regimens continue to improve, with the use of different immunosuppressive medications and newer therapeutic approaches such as biologic agents. We provide an overview of paediatric vasculitides focusing on HSP, KD, and polyarteritis nodosa (PAN). Key differences (where relevant) between paediatric and adult vasculitis are highlighted. In addition we discuss new emerging challenges particularly in respect to the long-term cardiovascular morbidity for children with systemic vasculitis, and emphasize the importance of future international multicentre collaborative studies to further increase and standardize the scientific base of investigating and treating childhood vasculitis.
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Conference papers on the topic "IgA Vasculitis"

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Thota, A., L. Ramirez, U. Naqvi, A. Mahgoub, and A. Abdelrahman. "An Unusual Presentation of IgA Vasculitis." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2032.

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Held, M., A. Kozmar, M. Sestan, D. Turudic, N. Kifer, S. Srsen, A. Gagro, M. Frkovic, and M. Jelusic. "POS0779 EXPLORING HMGB1, RAGE, Gd-IgA1 AND PCDH1 IN CHILDHOOD IgA VASCULITIS (IgAV)." In EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria. BMJ Publishing Group Ltd and European League Against Rheumatism, 2024. http://dx.doi.org/10.1136/annrheumdis-2024-eular.3908.

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Kobrová, Kateřina, Lenka Minxová, Jakub Zieg, Sylva Skálová, and Pavla Doležalová. "AB0998 SEVERE IGA VASCULITIS: CYCLOPHOSPHAMIDE IN QUESTION." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.6731.

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Parolo Ribeiro, Mirian, Fabiana de Castro Machado, Andreas Nogueira Sales, Anna Leticia Sant' Anna Yanai, Pedro Henrique Moriguchi Cação, Caio Polimeno Guerzoni, and Flavio Barboza. "JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS MIMICKING IGA VASCULITIS." In SBR 2021 Congresso Brasileiro de Reumatologia. Sociedade Brasileira de Reumatologia, 2021. http://dx.doi.org/10.47660/cbr.2021.1982.

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Camargo, Matheus Brunstein, Joana Mattioni Ourique, Sandra Helena Machado, Débora Kempf da Silva, and Janine Margutti Lanzanova. "COMPLICATED IGA VASCULITIS IN CHILDREN CASE REPORT." In XL Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2023. http://dx.doi.org/10.47660/cbr.2023.2450.

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Teles, Ana Beatriz Queiroz, Julia Cruvinel Rabello, Júlia Andrade Ibiapina Parente, Thaís Fernanda Faria Moreira, Letícia Mello Matos, Beatriz Araújo Gonçalves Coelho, Larissa Dayrell Albuquerque, et al. "ASSOCIATION BETWEEN PFAPA SYNDROME AND IGA VASCULITIS." In XL Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2023. http://dx.doi.org/10.47660/cbr.2023.2368.

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Perim, Gabriela Camilotti, Carolina Tiemi Tonholo Ikedo, Rodrigo Lorenzetti Serrano, Edgard Torres dos Reis Neto, Alexandre Wagner Silva de Souza, Bruna Romagna Peterle, Lígia Magalhães Biló, et al. "OVERLAP OF IGA-ASSOCIATED VASCULITIS AND PR3-ASSOCIATED ANCA VASCULITIS CASE REPORT." In XL Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2023. http://dx.doi.org/10.47660/cbr.2023.2039.

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Guliaev, Sergei, Leonid Strizhakov, Sergey Moiseev, Ivan Gmoshinskii, and Vladimir Mazo. "SAT0229 INTESTINAL PERMEABILITY IN IGA-VASCULITIS IN ADULTS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.3722.

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Nossent, J., W. Raymond, H. Keen, C. Inderjeeth, and D. Preen. "OP0239 Pregnancy outcomes in patients with iga vasculitis." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.6150.

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Batista-Liz, J. C., M. Sebastián Mora-Gil, L. Gabrie, R. Gálvez-Sánchez, M. T. Leonardo, A. Peñalba, B. Sevilla-Pérez, et al. "AB1240 NLRP3 AND CASP1 GENES AS DISCRIMINATORY MARKERS BETWEEN IGA VASCULITIS AND IGA NEPHROPATHY?" In EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria. BMJ Publishing Group Ltd and European League Against Rheumatism, 2024. http://dx.doi.org/10.1136/annrheumdis-2024-eular.4936.

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Reports on the topic "IgA Vasculitis"

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Tota, Maciej, Vanessa Baron, Bouchra Derrough, Katie Musial, Andrzej Konieczny, Magdalena Krajewska, Kültigin Türkmen, and Mariusz Kusztal. Secondary IgA Nephropathy without IgA vasculitis: a systematic review of case reports. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2023. http://dx.doi.org/10.37766/inplasy2023.2.0022.

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