Relevant bibliographies by topics / IgA

Academic literature on the topic 'IgA'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 March 2023

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Journal articles on the topic "IgA"

1

Hall, R. P., and T. J. Lawley. "Characterization of circulating and cutaneous IgA immune complexes in patients with dermatitis herpetiformis." Journal of Immunology 135, no. 3 (September 1, 1985): 1760–65. http://dx.doi.org/10.4049/jimmunol.135.3.1760.

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Abstract Dermatitis herpetiformis (DH) is a chronic, blistering skin disease characterized in part by deposits of IgA at the dermal-epidermal junction. Eighty-five percent of DH patients have granular IgA deposits and have an associated gluten-sensitive enteropathy (GSE). In contrast, 15% of DH patients have a linear pattern of IgA deposits and no associated intestinal abnormality. Although circulating IgA antibodies against skin are not present in these patients, 40% of DH patients do have IgA-containing circulating immune complexes (IgA-CIC). The role and origin of the cutaneous IgA and the IgA-CIC in patients with DH are unknown; however, the association of GSE with the granular IgA deposits suggests that a mucosal immune response may be important in the pathogenesis of DH. We have characterized the IgA subclass composition of the cutaneous IgA deposits in patients with DH, and have isolated and characterized the IgA-CIC from these patients. Twenty-nine of 29 patients with DH and granular IgA deposits were found to have only IgA1 deposits. Ten of 11 patients with linear IgA deposits also had only IgA1 deposits; one of 11 had IgA2 deposits. Isolated IgA-CIC from the sera of eight patients with DH and granular IgA deposits were found to contain both IgA1 (58% +/- 5, mean percent of total IgA +/- SEM) and IgA2 (42% +/- 5), as were IgA-CIC from two patients with ordinary GSE without cutaneous IgA deposits. The IgA subclass composition of the isolated immune complexes was significantly different from the serum IgA1 and IgA2 composition (serum IgA1 = 76% +/- 6; IgA2 = 24% +/- 5, p less than 0.025, Student's t-test), and suggests that the IgA-CIC may arise from gut-associated lymphoid tissue (GALT). Sequential anti-IgA1 absorption of serum which contained IgA-CIC did not remove all the IgA-CIC, suggesting that the complexes circulate as separate IgA1 and IgA2 complexes. The finding of IgA1 alone in the skin of patients with DH suggests that the cutaneous IgA may not arise from GALT, or that IgA1, possibly arising in GALT, is preferentially bound to DH skin. Because IgA-containing CIC which contain both IgA1 and IgA2 were found in the serum of patients with DH and with ordinary GSE, it seems unlikely that IgA-containing CIC are responsible for the cutaneous IgA deposits seen in DH.
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Chevailler, A., R. C. Monteiro, H. Kubagawa, and M. D. Cooper. "Immunofluorescence analysis of IgA binding by human mononuclear cells in blood and lymphoid tissue." Journal of Immunology 142, no. 7 (April 1, 1989): 2244–49. http://dx.doi.org/10.4049/jimmunol.142.7.2244.

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Abstract The nature of IgA-binding cells and their tissue distribution was examined by an indirect immunofluorescence assay with the use of IgA1 and IgA2 paraproteins and fluorochrome- or biotin-labeled F(ab')2 fragments of idiotype-specific antibodies. The frequency of IgA-binding mononuclear cells was approximately 13% in blood and spleen samples but less than 1% in tonsil samples. IgA binding could be visualized by flow immunocytometry on monocyte/macrophages, but not on T and B cells. IgA polymers were bound better than IgA dimers and monomers. Nonhomologous IgA myelomas of both IgA1 and IgA2 subclasses inhibited the IgA-binding to monocytes, whereas aggregated normal serum IgG, IgM paraproteins, and an IgG myeloma did not. IgA binding was relatively insensitive to changes in temperature or cation concentration. IgA-binding monocytes were found in IgA-deficient patients at the same frequency as in normal individuals. The results indicate that monocytes constitutively express class-specific binding sites for both IgA1 and IgA2 molecules.
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Derksen, V., C. Allaart, A. van der Helm-van Mil, T. Huizinga, R. Toes, and D. van der Woude. "AB0077 IN RHEUMATOID ARTHRITIS PATIENTS, TOTAL IgA1 AND IgA2 LEVELS ARE ELEVATED: IMPLICATIONS FOR THE MUCOSAL ORIGIN HYPOTHESIS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1170.2–1171. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2829.

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BackgroundMucosal surfaces may be involved in the pathophysiology of rheumatoid arthritis (RA) (1). IgA is the most abundant class of immunoglobulin at mucosal sites. Therefore, it is worthwhile to study this isotype in RA patients in more detail. Humans have two IgA subclasses, IgA1 and IgA2, which are not evenly distributed. IgA1 is dominant in serum, whereas IgA1 and IgA2 are more balanced at mucosal surfaces (2). Besides these differences in location, IgA2 has also been ascribed pro-inflammatory properties (3).ObjectivesAs IgA subclasses might provide new insights into mucosal involvement and potential pro-inflammatory mechanisms, we investigated total and autoantibody-specific IgA subclasses responses in sera of rheumatoid arthritis patients.MethodsSera from two cohorts of RA patients, the IMPROVED (baseline visit) and the EAC (1-year visit), were selected based on previous autoantibody measurements. All patients fulfilled the 1987 (EAC) or 2010 (IMPROVED) ACR criteria for RA. Total IgA subclasses and IgA subclasses of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) were measured using (in-house) ELISA’s, and compared to healthy donors. Associations between these IgA subclass levels and markers of inflammation (CRP and disease activity score (DAS)) were investigated using Spearman’s rank correlation. Mann–Whitney U tests were performed to investigate the association between IgA1 and IgA2 levels and smoking, a proxy for chronic mucosal inflammation. To correct for confounders, a multivariate linear model including age, gender, CRP and smoking was used.ResultsTotal IgA1 and IgA2 levels were increased in RA patients compared to healthy donors in both cohorts (Figure 1A-C, data IMPROVED). This increase was more pronounced in seropositive RA versus seronegative RA. Both total IgA subclasses were raised to the same extent, since the percentage of IgA2 of total IgA in serum did not differ between patients and healthy donors. In seropositive patients, RF and anti-CCP2 IgA1 and IgA2 could be detected, but measurements of anti-CCP2 IgA2 levels proved challenging due to interference of RF IgA. Although IgA2 has been postulated to be more proinflammatory, no correlations were found between total, RF and ACPA IgA subclass levels and DAS. An association between CRP and RF IgA2 was observed, but the effect size was small and did not remain significant after correction for multiple testing in the EAC. In smoking seropositive RA patients, a trend towards a selective increase in total IgA2 and RF IgA1 and IgA2 was observed (Figure 1D, data IMPROVED seropositive RA).Figure 1.ConclusionSeropositive RA patients have raised IgA1 and IgA2 levels and can also harbor RF and ACPA IgA subclasses. No shift towards IgA2 was observed, indicating that the increase in total IgA is not due to translocation of mucosal IgA into the bloodstream. However, chronic mucosal inflammation might be one of the mechanisms involved in the raise in IgA(2) levels in RA, given the association between smoking and total IgA2 levels. Despite its’ pro-inflammatory properties, no strong associations between IgA2 and markers of inflammation were found, which suggests that IgA2 does not play a essential role in the ongoing pro-inflammatory processes in RA patients.References[1]Holers VM, Demoruelle MK, Kuhn KA, et al. Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction. Nature Reviews Rheumatology. 2018;14(9):542-57.[2]Woof JM, Russell MW. Structure and function relationships in IgA. Mucosal Immunol. 2011;4(6):590-7.[3]Steffen U, Koeleman CA, Sokolova MV, et al. IgA subclasses have different effector functions associated with distinct glycosylation profiles. Nat Commun. 2020;11(1):120.Disclosure of InterestsNone declared
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Pakkanen, Sari H., Jussi M. Kantele, Zina Moldoveanu, Spencer Hedges, Miikka Häkkinen, Jiri Mestecky, and Anu Kantele. "Expression of Homing Receptors on IgA1 and IgA2 Plasmablasts in Blood Reflects Differential Distribution of IgA1 and IgA2 in Various Body Fluids." Clinical and Vaccine Immunology 17, no. 3 (January 20, 2010): 393–401. http://dx.doi.org/10.1128/cvi.00475-09.

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ABSTRACT Although secretory IgA is the most abundantly produced Ig isotype, the mechanisms underlying the differential distribution of IgA subclasses in various body fluids remain unclear. To explore these mechanisms, we examined the distribution of IgA subclasses, the influence of the nature and sites of encounters with antigens, and the correlation between IgA subclass distribution and homing potentials of circulating IgA plasmablasts. IgA1 predominated in serum, tears, nasal wash fluid, and saliva; the levels of IgA1 and IgA2 were comparable in vaginal wash fluid; and IgA2 predominated in intestinal lavage fluids. Seventy-one percent of circulating IgA plasmablasts secreted IgA1. The intestinal homing receptor (HR), α4β7, was expressed more frequently on IgA2 than on IgA1 plasmablasts, with no differences in the expression of other HRs. IgA subclass distribution among circulating antigen-specific antibody-secreting cells (ASC) was dependent on the nature of the antigen: following vaccination with Salmonella enterica serovar Typhi, unconjugated pneumococcal polysaccharide, or Haemophilus influenzae polysaccharide-diphtheria toxoid conjugate, the proportions of specific IgA1 ASC were 74%, 47%, 56%, and 80%, respectively. HR expression depended on the route of administration: expression of HRs was different after oral than after parenteral vaccination, while no difference was seen between HR expression of antigen-specific IgA1 and IgA2 ASC induced via the same route. The key factors determining IgA subclass distribution in a given secretion are the nature of the antigens encountered at a particular site and the site-specific homing instructions given to lymphocytes at that site. These two factors are reflected as differences in the homing profiles of the total populations of circulating IgA1 and IgA2 plasmablasts.
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Heilmann, C., T. Barington, and T. Sigsgaard. "Subclass of individual IgA-secreting human lymphocytes. Investigation of in vivo pneumococcal polysaccharide-induced and in vitro mitogen-induced blood B cells by monolayer plaque-forming cell assays." Journal of Immunology 140, no. 5 (March 1, 1988): 1496–99. http://dx.doi.org/10.4049/jimmunol.140.5.1496.

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Abstract The subclass of individual human IgA B cells was investigated by means of monolayer plaque-forming cell assays permitting analysis of all IgA-secreting cells as well as of cells secreting IgA anti-pneumococcal polysaccharide antibody. Center cells were examined by indirect immunofluorescence staining with mouse mAb against either of the two IgA subclasses as primary antibodies and FITC-conjugated rabbit anti-mouse Ig as the second antibody. Blood lymphocytes spontaneously secreting IgA (mean 399/10(6) mononuclear cells) produced mainly IgA1 (73%). A similar distribution of subclasses was recorded among IgA-secreting blood cells in PWM- and EBV-stimulated cultures. In contrast, a predominance of IgA2 (54%) was found among IgA-secreting cells (2531/10(6)) isolated from the blood 7 days after in vivo stimulation with pneumococcal polysaccharides, and a similar proportion (51%) of IgA2 producing cells was found among IgA anti-pneumococcal polysaccharide-secreting cells. It was thus confirmed that IgA1 is the predominant subclass of blood IgA-secreting cells in general. However, the high percentage of IgA2-secreting cells found after vaccination with pneumococcal polysaccharides suggests that these Ag have an unusually high ability to activate IgA2 B cells, or that the B cells stimulated originate from lymphatic tissues with a high frequency of IgA2 committed cells.
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Heck, L. W., P. G. Alarcon, R. M. Kulhavy, K. Morihara, M. W. Russell, and J. F. Mestecky. "Degradation of IgA proteins by Pseudomonas aeruginosa elastase." Journal of Immunology 144, no. 6 (March 15, 1990): 2253–57. http://dx.doi.org/10.4049/jimmunol.144.6.2253.

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Abstract Human colostral IgA and myeloma proteins of both IgA1 and IgA2 subclasses were susceptible to cleavage by Pseudomonas aeruginosa elastase. Detailed analysis of the cleavage products of IgA myeloma proteins revealed complete degradation of Fab with no evidence of intact Fab fragments as intermediate cleavage products. In contrast, both IgA1 and IgA2 proteins were resistant to cleavage by alkaline protease from P. aeruginosa. The susceptibility of human IgA proteins to elastase suggests a mechanism by which P. aeruginosa might evade the potentially protective function of IgA by producing this enzyme.
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Mazengera, R. L., and M. A. Kerr. "The specificity of the IgA receptor purified from human neutrophils." Biochemical Journal 272, no. 1 (November 15, 1990): 159–65. http://dx.doi.org/10.1042/bj2720159.

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A receptor for IgA was purified from human polymorphonuclear neutrophils (PMN) by affinity chromatography on human serum IgA-Sepharose. The receptor appeared on SDS/polyacrylamide gels as a diffuse band with an apparent molecular mass of 50-70 kDa, whether reduced or non-reduced. During purification, the protein showed remarkable stability to proteolytic digestion by endogenous PMN proteinases. Purified radioiodinated receptor re-bound to IgA-Sepharose, but not to IgG-Sepharose or BSA-Sepharose. The binding of the receptor to IgA-Sepharose was inhibited in a dose-dependent manner by human serum IgA1 or IgA2 or secretory IgA1 or IgA2, but not by IgG or IgM. Binding of receptor to IgA-Sepharose was also inhibited by the Fc fragment of IgA, but not by the Fab fragment. An IgA fragment produced by digestion with pepsin which lacks the CH3 domain also inhibited binding, but to a more limited extent than did the whole IgA molecule.
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Engström, P. E., G. Norhagen, A. Bottaro, A. O. Carbonara, G. Lefranc, M. Steinitz, P. O. Söder, C. I. Smith, and L. Hammarström. "Subclass distribution of antigen-specific IgA antibodies in normal donors and individuals with homozygous C alpha 1 or C alpha 2 gene deletions." Journal of Immunology 145, no. 1 (July 1, 1990): 109–16. http://dx.doi.org/10.4049/jimmunol.145.1.109.

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Abstract To analyze the subclass restriction of Ag-specific IgA, sera and saliva from healthy blood donors and from IgA class or subclass deficient individuals were studied. The latter included donors with or without C alpha 1 or C alpha 2 gene deletions. Monoclonal human IgA1 and a genetically engineered IgA2 antibody, normal human serum and colostrum IgA were used as standards to estimate serum and saliva levels of Ag-specific antibodies. In normal individuals, there was a strong IgA1 preference of naturally acquired antibodies in serum against both polysaccharide Ag (PPS 6A, PPS 23, pneumococcal C-polysaccharide, and LPS from Escherichia coli) and protein Ag (Staphylococcus aureus alpha-toxin and HSV). Specific IgA2 in serum against the tested Ag were frequently not measurable. In contrast, most of the individuals with homozygous C alpha 1 gene deletions displayed substantial amounts of specific IgA2 against protein as well as polysaccharide Ag. The median levels of specific IgA in serum against protein Ag were approximately one-third as compared to normal individuals and one-fifth, or less, against polysaccharide Ag. Normal serum levels of IgA against the tested Ag, restricted to the IgA1 subclass, were noted in two individuals with IgA2 deficiency, one of whom carried a homozygous C alpha 2 gene deletion. Median values of specific IgA, against the tested Ag S. aureus alpha-toxin, HSV, and pneumococcal C-poly-saccharide, from normal healthy donors were approximately four to eight times higher in serum as compared to saliva. Individuals with homozygous C alpha 1 gene deletions displayed increased levels of the various specific IgA2 antibodies in saliva. In conclusion, the individuals with homozygous C alpha 1 gene deletions displayed decreased median levels of specific IgA antibodies in serum despite normal levels of total IgA. Normal levels of both specific IgA and total IgA in saliva were found.
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Jackson, S., R. I. Montgomery, J. Mestecky, and C. Czerkinsky. "Normal human sera contain antibodies directed at Fab of IgA." Journal of Immunology 138, no. 7 (April 1, 1987): 2244–48. http://dx.doi.org/10.4049/jimmunol.138.7.2244.

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Abstract Serum samples from 26 normal volunteers were evaluated by isotype-specific ELISA for the presence of IgG and IgM antibodies directed at IgA. Although there were wide variations in antibody levels, anti-IgA antibodies of both isotypes were found in all individuals tested. The anti-IgA activity was detected against a variety of polymeric and monomeric IgA1 and IgA2 myeloma proteins containing both kappa and lambda light chains. By using Fab and Fc fragments generated by incubation of an IgA1 myeloma protein with IgA1 protease, it was shown that the anti-IgA activity was specific for the Fab portion of the IgA molecule. It was also demonstrated that the serum of two individuals contained both IgG and IgM activity directed at autologous affinity-purified IgA. IgM antibody levels against both whole IgA and Fab of IgA were significantly higher than IgG antibody levels. Cells producing anti-IgA antibodies of both isotypes were detected in lipopolysaccharide-stimulated human spleen.
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Conley, M. E., M. A. Chan, and N. H. Sigal. "In vitro regulation of IgA subclass production. III. Selective transformation of IgA1 producing cells by Epstein-Barr virus." Journal of Immunology 138, no. 5 (March 1, 1987): 1403–7. http://dx.doi.org/10.4049/jimmunol.138.5.1403.

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Abstract In past experiments, using limited dilution analysis, we have demonstrated that a high percentage of immunoglobulin-secreting clones derived from Epstein-Barr virus- (EBV) stimulated lymphocytes secrete IgA. To further characterize the IgA produced by these clones, the IgA subclass of supernatants from clones stimulated 4 to 6 wk previously with EBV was determined by radioimmunoassay. All of 17 IgA-producing clones secreted IgA1; none secreted IgA2. Because we have shown that surface IgM+ (sIgM+) B cells are an enriched source of IgA2 plasma cell precursors, panning techniques were used to purify sIgM+ B cells from tonsils. Of 103 clones derived from these sIgM+ B cells, 102 secreted IgA1 and only one secreted IgA2. The relative absence of IgA2-producing clones could not be attributed to an absence of EBV receptors on IgA2 cells. A mean of 84 +/- 4% of freshly isolated IgA2 B cells and 78 +/- 6% of IgA1 B cells could be stained with a monoclonal antibody binding the EBV receptor; and there was no failure of EBV to infect IgA2 plasma cells precursors. Of IgA2 plasma cells derived from peripheral blood lymphocytes stimulated 7 days previously with EBV, 54 +/- 7% were positive for the EBV nuclear antigen, compared with 54 +/- 18% of IgA1 plasma cells from the same cultures. Seven days after EBV stimulation, a mean of 25% of the total IgA plasma cells were positive for cytoplasmic IgA2, whereas by 21 days after stimulation only 7% were positive for IgA2. This shift in the proportions of IgA1 and IgA2 plasma cells could be attributed to a failure of the IgA2 plasma cell number to increase after 10 days in culture. There was no evidence for selective suppression of IgA2 production by T cells or selective lysis of IgA2 plasma cells by infectious EBV particles. These results demonstrate that although precursors for both IgA1- and IgA2-producing cells can be stimulated to differentiate in response to EBV, there is preferential transformation of IgA1-producing cells.
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Dissertations / Theses on the topic "IgA"

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Suzuki, Lisandra Akemi. "Resposta imune humoral na neurocisticercose." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308741.

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Orientador: Claudio Lucio Rossi
Tese (doutorado) - Universidade Estadual de Campinas. Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-15T09:51:57Z (GMT). No. of bitstreams: 1 Suzuki_LisandraAkemi_D.pdf: 1217880 bytes, checksum: 4ceb1f773f112c88145bc69e02976ef2 (MD5) Previous issue date: 2010
Resumo: A neurocisticercose (NC) e uma importante causa de doença neurológica em muitos paises em desenvolvimento, incluindo o Brasil. O diagnostico clinico da NC e dificultado pelo polimorfismo e pela não especificidade dos sintomas. As tecnicas de neuroimagem e pesquisa de anticorpos específicos tem contribuído para o diagnostico da NC e uma melhor compreensão dos processos fisiopatológicos dessa infecção. O presente trabalho teve como objetivo avaliar, por meio de técnicas imunoenzimaticas (ELISA), a resposta imune humoral na NC, utilizando como preparações antigênicas o liquido vesicular (LV) e uma fração glicoproteica obtida do extrato bruto de cisticercos de Taenia solium (T. solium) com afinidade por lentil-lectina (fração Gp). Cinquenta e seis amostras de liquido cefalorraquidiano (LCR), 22 de pacientes com NC e 34 de pacientes com outros problemas neurológicos, foram utilizadas para a pesquisa de IgG e suas subclasses, com os seguintes resultados: IgG-LV: 100% de sensibilidade e especificidade; IgG1 -LV: 72,73% de sensibilidade e 100% de especificidade; IgG2-LV: 81,81% de sensibilidade e 100% de especificidade; IgG3-LV: 59,09% de sensibilidade e 97,06% de especificidade; IgG4-LV: 90,91% de sensibilidade e 97,06% de especificidade; IgG-fração Gp: 90,91% de sensibilidade e 97,06% de especificidade; IgG1-fração Gp: 59,09% de sensibilidade e 91,18% de especificidade; IgG2-fração Gp: 68,18% de sensibilidade e 94,12% de especificidade; IgG3-fração Gp: 36,36% de sensibilidade e 100% de especificidade; IgG4-fração Gp: 86,36% de sensibilidade e 100% de especificidade. Quarenta e sete amostras de LCR, 16 de pacientes com NC e 31 de pacientes com outros problemas neurológicos foram utilizadas para a pesquisa de IgE, com os seguintes resultados: IgE-LV e IgE-fração Gp: 93,75% de sensibilidade e 100% de especificidade. Cinquenta e sete amostras de soros, 22 de pacientes com NC, 18 de pacientes com outras infecções e 17 de pessoas presumivelmente sadias, foram utilizadas para a pesquisa da IgG e suas subclasses, IgE, IgA e IgM, com os seguintes resultados: IgG-LV: 100% de sensibilidade e especificidade; IgG1-LV: 86,36% de sensibilidade e 94,28% de especificidade; IgG2-LV: 90,91% de sensibilidade e 97,14% de especificidade; IgG3-LV: 86,36% de sensibilidade e 97,14% de especificidade; IgG4-LV: 100% de sensibilidade e de especificidade; IgG-fração Gp: 95,45% de sensibilidade e 100% de especificidade; IgG1-fração Gp: 63,64% de sensibilidade e 94,28% de especificidade; IgG2-fração Gp: 68,18% de sensibilidade e 97,14% de especificidade; IgG3-fração Gp: 54,54% de sensibilidade e 88,57% de especificidade; IgG4-fração Gp: 90,91% de sensibilidade e 100% de especificidade; IgELV: 90,91% de sensibilidade e 97,14% de especificidade; IgE-fração Gp: 86,36% de sensibilidade e 100% de especificidade; IgA-LV: 54,54% de sensibilidade e 94,28% de especificidade; IgA-fração Gp: 13,63% de sensibilidade e 100% de especificidade. Anticorpos IgM não foram detectados com as preparações de LV e fração Gp. Nossos resultados mostraram que, com ambas as preparações antigênicas, tanto em amostras de LCR quanto em amostras de soros, a maior positividade foi obtida na detecção de anticorpos das classes IgG e IgE, seguida da positividade da IgA. Anticorpos IgM não foram detectados em amostras de soros com reações de ELISA realizadas com LV e fração Gp. Com relação as subclasses da IgG, a IgG4 apresentou, tanto em amostras de LCR como em amostras de soros, valores de positividade e concentração iguais ou superiores as outras subclasses. As reações ELISA realizadas com LV mostraram sensibilidades iguais ou superiores aquelas obtidas com a fração Gp. Considerando a complexidade e o custo final da obtenção da fração Gp, o LV pode ser considerado mais adequado para a pesquisa de anticorpos em amostras de LCR e soros de pacientes com NC.
Abstract: Neurocysticercosis (NC) is an important cause of neurological disease in many developing countries, including Brazil. The clinical diagnosis of NC is hindered by the polymorphism and non-specificity of the symptoms. Neuroimaging techniques and detection of specific antibodies have contributed to the diagnosis of NC and a better understanding of the physiopathological processes of this infection. The purpose of this study was to evaluate the humoral immune response in NC by using immunoenzymatic techniques (ELISA) in which vesicular fluid (VF) and a glycoprotein fraction purified from a crude extract of Taenia solium cysticerci with affinity for lentil-lectin (fraction Gp) were used as antigenic preparations. Fifty-six cerebrospinal fluid (CSF) samples, 22 from patients with NC and 34 from patients with other neurological disorders, were assayed for IgG and IgG subclasses, with the following results: IgG-VF: 100% sensitivity and specificity, IgG1 - VF: 72.73% sensitivity and 100% specificity, IgG2 -VF: 81.81% sensitivity and 100% specificity, IgG3 -VF: 59.09% sensitivity and 97.06% specificity, IgG4 -VF: 90.91% sensitivity and 97.06% specificity, IgG-fraction Gp: 90.91% sensitivity and 97.06% specificity, IgG1- fraction Gp: 59.09% sensitivity and 91.18% specificity, IgG2-fraction Gp: 68.18% sensitivity and 94.12% specificity, IgG3 -fraction Gp: 36.36% sensitivity and 100% specificity, IgG4 - fraction Gp: 86.36% sensitivity and 100% specificity. Forty-seven CSF samples, 16 from patients with NC and 31 from patients with other neurological disorders, were assayed for IgE, with the following results: IgE-VF and IgE-fraction Gp: 93.75% sensitivity and 100% specificity. Fifty-seven serum samples, 22 from patients with NC, 18 from patients with other infections and 17 from presumably healthy individuals, were assayed for IgG, IgG subclasses, IgE, IgA and IgM, with the following results: IgG-VF: 100% sensitivity and specificity, IgG1-VF: 86.36% sensitivity and 94.28% specificity, IgG2 -VF: 90.91% sensitivity and 97.14% specificity, IgG3 -VF: 86.36% sensitivity and 97.14% specificity, IgG4 -VF:100% sensitivity and specificity, IgG-fraction Gp: 95.45% sensitivity and 100% specificity, IgG1- fraction Gp: 63.64% sensitivity and 94.28% specificity, IgG2 -fraction Gp: 68.18% sensitivity and 97.14% specificity, IgG3 -fraction Gp: 54.54% sensitivity and 88.57% specificity, IgG4 - fraction Gp: 90.91% sensitivity and 100% specificity, IgE-VF: 90.91% sensitivity and 97.14% specificity, IgE-fraction Gp: 86.36% sensitivity and 100% specificity, IgA-VF: 54.54% sensitivity and 94.28% specificity, IgA-fraction Gp: 13.63% sensitivity and 100% specificity. No specific IgM antibodies were detected with VF and fraction Gp antigenic preparations. These results show that with the two antigenic preparations the highest positivity in CSF and serum samples was obtained for IgG and IgE antibodies, followed by positivity for IgA. No IgM antibodies were detected in serum samples assayed with VF and fraction Gp. With regard to IgG subclasses, IgG4 positivity and concentration in CSF and serum samples were higher than or equal to the other subclasses. ELISA reactions done with VF showed equal or higher sensitivities than those obtained with fraction Gp. Considering the complexity and high cost of obtaining fraction Gp, VF could be more suitable for detecting specific antibodies in CSF and serum samples from patients with NC.
Doutorado
Ciencias Biomedicas
Doutor em Ciências Médicas
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2

Layward, Lorna. "IgA in IgA nephropathy." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34129.

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IgA in IgA Nephropathy Lorna Layward IgA nephropathy is a common glomerulonephritis of unknown pathogenesis, characterised by the presence of IgA within the glomerular mesangium. The predominant subclass of deposited IgA is known to be of the subclass IgA1 and is, at least in part, polymeric. IgA subclass measurements showed that raised serum IgA levels were restricted to the IgAl subclass, and that increased IgA levels were only observed in the systemic (not mucosal) compartment of the IgA immune system. In vitro production of IgA by peripheral blood lymphocytes was increased, with a concomitant decrease in IgG production. The response to systemic challenge with tetanus toxoid demonstrated a bias towards serum IgA1 antibody production; an enhanced circulating antigen-specific B cell response; and a positive saliva response where none was observed in controls. Serum polymeric IgA antibody production in response to systemic antigen challenge was significantly elevated in IgA nephropathy. Patients with IgA nephropathy were more likely to have an IgG subclass antibody deficiency than controls, showing dysregulation of other isotypes besides IgA. The affinity of serum IgA antibodies produced was lower than controls, while IgG affinity was normal. The production of low affinity IgA antibodies may result in the formation of nephritogenic immune complexes and explain the predominance of IgA within the glomerular mesangium. Gut permeability was normal in IgA nephropathy, and the response to mucosal antigen challenge did not differ from controls except for a higher antigen-specific in vitro B cell response. These results suggest an enhanced overlap of circulating IgA immunocompetent IgA B cells between the two sites in IgA nephropathy, regardless of the route of antigen administration. These data show abnormalities of mainly systemic IgA lending support to the hypothesis that the source of IgA overproduction is the systemic rather than the mucosal compartment of the IgA immune system.
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Allen, Alice. "IgA glycosylation in IgA nephropathy." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/35028.

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IgA nephropathy (IgAN) is a common glomerulonephritis characterised by deposition of IgA1 in the glomerular mesangium The underlying abnormality lies within the IgA system rather than the kidney, and modest irregularities of IgA biology have been described, but the mechanisms involved in IgA1 deposition and glomerular injury remain elusive. A few reports have suggested an abnormality of the carbohydrate component of IgA1 in IgAN. These studies sought to confirm and further characterise the putative glycosylation defect and to identify its biochemical basis. Lectin binding assays were developed and used to analyse the N- and O-linked glycans of IgA1 in IgAN and controls. No gross abnormality of N-glycosylation was detected in IgAN, though these studies were subject to technical limitations. IgA1 in IgAN displayed significantly increased binding to lectins with affinity for O-linked N-acetylgalactosamine (Ga1NAc) as compared to controls. One explanation for this finding is reduced terminal galactosylation of the O-linked sugars of IgA1. A novel assay was developed to measure the functional activity of alpha1,3 galactosyltransferase (alpha1,3GT), the enzyme responsible for O-galactosylation, in cell lysates. In IgAN, peripheral blood B cells appeared to show significantly lower alpha1,3GT activity than controls, and this was inversely proportional to Ga1NAc expression of serum IgA1 as measured by lectin binding. These studies confirm an abnormality of O-linked glycosylation of serum IgA1 in IgAN, which may be attributed to low B cell alpha1,3GT activity. Altered O-glycosylation of IgA1 may be relevant to the pathogenesis of IgAN.
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Sellers, Lisa K. "Exercise-induced alterations in immunoglobulin (IgA, IgG, IgM) levels in cancer versus non-cancer patients." Muncie, Ind. : Ball State University, 2008. http://cardinalscholar.bsu.edu/384.

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Millet, Isabelle. "Récepteurs pour les IgA et propriétés biologiques des facteurs liant les IgA : iga-bf." Lyon 1, 1988. http://www.theses.fr/1988LYO1T156.

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Millet, Isabelle. "Récepteurs pour les IgA et propriétés biologiques des facteurs liant les IgA (IgA-BF)." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37616528s.

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Leung, Chi-kam Joseph, and 梁志錦. "The pathogenesis of IgA nephropathy: the roleof IgA molecule and the nature of IgA receptors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29744908.

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Wehbe, Batoul. "IgA et rein : destructrice ou protectrice ? : Rôles de l'immunoglobuline A (IgA) dans deux pathologies rénales." Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0034/document.

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L’immunoglobuline A (IgA) est l’immunoglobuline la plus abondamment synthétisée chez les mammifères. Ses propriétés ambivalentes l’impliquent non seulement dans des fonctions de protection contre les agents pathogènes mais aussi dans des phénomènes de tolérance immunitaire vis-à-vis des germes commensaux du microbiote. Toutefois, les IgA peuvent développer des propriétés pathogènes. Dans la première partie de mon travail de thèse, nous avons étudié les effets pathogènes de l’IgA. Les dépôts d’IgA sur le mésangium sont la caractéristique de l’IgAN. La physiopathologie de cette maladie est mal connue. L’hypothèse d’un défaut de glycosylation de l’IgA est souvent retenue ; ce défaut peut être la cause de sa polymérisation et de son antigénicité, il peut aussi favoriser le clivage du récepteur CD89. Nous avons analysé l’effet du défaut d’affinité de la région variable des IgA, de la substitution de la chaîne légère ainsi que de l’association des IgA à leur récepteur, le CD89 sur l’induction des lésions et le dysfonctionnement rénal chez quatre modèles murins différents générés au laboratoire et suivis pendant 12 mois. Nous avons également étudié les propriétés physico-chimiques des IgA de 28 patients ayant une dysglobulinémie et de 28 IgA produites par des hybridomes ; la relation entre ces propriétés et la capacité des IgA à se déposer a été observée. Dans une seconde partie, nous avons étudié l’aspect immunomodulateur et les propriétés antiinflammatoires conférées par l’IgA humaine surexprimée chez un modèle murin de lupus systémique (souris MRL/lpr). Dans la dernière partie du travail, nous avons contribué à la caractérisation d’un modèle de souris transgénique exprimant l’IgA de classe 2 et à l’étude de l’effet de signalisation médiée par cette IgA2 sur le développement des populations lymphocytaires. L’ensemble de ces travaux a montré l’effet pathogène des IgA naturelles ayant une faible affinité sur le développement de la néphropathie à IgA ; ainsi les analyses des IgA des patients et des hybridomes montrent que c’est la stabilité moléculaire de préférence au profil de glycosylation qui joue un rôle crucial dans leur capacité de dépôt. L’expression des IgA humaines chez les souris lupiques a considérablement prolongé leur durée de vie et a ralenti la survenue de l’auto-immunité et de l’atteinte rénale ce qui témoigne du rôle anti-inflammatoire des IgA. L’étude du modèle murin exprimant l’IgA2 humaine a montré que la signalisation via l’IgA2 joue un rôle inhibiteur sur le développement précoce de certaines sous-populations de cellules B. L’ensemble de ces résultats montrent la multitude d’effets de l’IgA lui permettant d’intervenir d’une part dans la pathogenèse d’une maladie complexe (l’IgAN) et d’autre part dans la protection de l’auto-immunité, témoignant de la complexité des interactions mises en jeu et du caractère régulateur de cette immunoglobuline
Immunoglobulin A (IgA) is the most synthetized immunoglobulin in mammals. IgA has ambivalent properties: it is implicated in the mechanisms of defense against pathogens but also in the immune tolerance of commensal microbiota. However, IgA can develop pathogenic properties. In the first part of my thesis, we studied the pathogenic effects of IgA. IgA deposits are the main characteristic of IgA nephropathy (IgAN). IgAN physiopathology is not yet clearly understood. The hypothesis of a glycosylation defect is strongly adapted. This defect can be due to IgA polymerization or antigenicity. It can also induce shedding of CD89 (IgA Fc receptor) or other factors. We studied the effect of variable region altered affinity, the light chain substitution and the association of IgA with CD89 on the development of kidney lesions and impairment of kidney function in four mouse models followed up during 12 months. In addition, we studied the physico-chemical properties of 28 IgA purified from patients with dysglobulinaemia and 28 chimeric IgA produced by hybridomas. The effect of these properties on the propensity of IgA for mesangial deposition was explored. In the second part, we studied the immunomodulatory and anti-inflammatory properties conferred by the overexpression of human IgA in a mouse model with systemic lupus (MRL/lpr model). In the last part, we contributed to the characterization of a transgenic mouse model producing IgA class 2 and to the study of the effect of IgA2-mediated signaling on B lymphocyte development. Altogether, obtained results show the pathogenic effect of low affinity-IgA on the development of IgA nephropathy. In addition, different analyses showed that molecular stability but not glycosylation profile is the determining factor for IgA deposition. On the other hand, IgA expression in lupus-prone mice extended their survival, delayed the onset of auto-immunity and ameliorated kidney functions in these animals which supports IgA anti-inflammatory properties. The study of IgA2-mediated signaling in the transgenic model showed the inhibitory effect of IgA2 on the early development of several B cell sub-populations. All of these results show the multiple effects of IgA which contribute on one hand to the pathogenesis of a complex disease (IgAN) and on the other hand to protection from autoimmunity, demonstrating the complexity of interactions and the regulatory character of this immunoglobulin
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Nascimento, Fernanda Santos. "Diagnostico sorologico da toxoplasmose." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308746.

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Orientador: Claudio Lucio Rossi
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: A toxoplasmose, uma zoonose com ampla distribuição mundial, causada pelo parasita intracelular obrigatório Toxoplasma gondii, é geralmente adquirida por meio da ingestão de cistos ou oocistos viáveis do parasita, presentes, respectivamente, em carne crua ou mal cozida e no solo, alimento ou água contaminados com fezes de gatos infectados. A toxoplasmose pode ser altamente debilitante, e ocasionalmente fatal, em crianças infectadas no útero e em receptores de transplante. O diagnóstico de infecção aguda primária em mulheres grávidas é geralmente baseado em testes sorológicos, visto que, na grande maioria dos casos, a toxoplasmose não é reconhecida clinicamente. A longa persistência dos anticorpos IgM em algumas pessoas e a dificuldade para demonstrar soroconversão ou aumento significativo da concentração de anticorpos específicos, têm complicado a interpretação dos testes sorológicos, quando se suspeita de infecção aguda. Com relação à infecção toxoplámica em pacientes transplantados, em muitos casos o status sorológico do doador não é conhecido e a pesquisa periódica de anticorpos anti-T. gondii no receptor raramente é realizada. O objetivo do primeiro estudo foi determinar o valor da demonstração dos anticorpos IgA anti-T.gondii para o diagnóstico da fase aguda da infecção toxoplásmica. Nossos resultados mostraram que os anticorpos IgA são detectados com alta freqüência em amostras de soros obtidas de mulheres com evidência clínica e/ou sorológica de infecção toxoplásmica aguda. Entretanto, em 19% das mulheres apresentando persistência de anticorpos IgM e alto índice de avidez dos anticorpos IgG, anticorpos IgA anti-T. gondii foram detectados em amostras de soros coletadas mais de 9 meses após o início da infecção, indicando que esses anticorpos não podem ser considerados marcadores confiáveis de infecção aguda primária. No segundo estudo, nós relatamos o diagnóstico de infecção toxoplásmica primária em um paciente com mieloma múltiplo submetido a transplante alogênico não-mieloablativo de células hematopoiéticas, provenientes de doador com sorologia negativa para toxoplasmose. A resposta primária contra o T. gondii foi baseada na soroconversão dos anticorpos IgM, IgG e IgA. O paciente foi prontamente tratado e nenhuma complicação relacionada à toxoplasmose foi observada nos meses subseqüentes. Esse caso ressalta a necessidade da detecção dos anticorpos anti-T. gondii no doador e no receptor antes do transplante e a importância do monitoramento sorológico do receptor durante o seguimento pós-transplante
Abstract: Toxoplasmosis, a cosmopolitan zoonotic disease caused by the intracellular parasite Toxoplasma gondii, is usually acquired through the ingestion of viable parasite cysts or oocysts, present, respectively, in raw or undercooked meat and in soil, food or water contaminated with feces of infected cats. Toxoplasmosis can be highly debilitating and occasionally fatal in children infected in utero and in transplant recipients. The diagnosis of acute primary infection in pregnant women is usually based on serology, because in the great majority of cases primary infection is not recognized clinically. The sustained persistence, in some persons, of specific IgM antibodies and the difficulty in demonstrating seroconversion or a significant increase in specific antibody concentrations, have complicated the interpretation of serological tests when acute infection is suspected. With regard to toxoplasmic infection in transplant patients, in many cases the serological status of the donor is not known and the periodic research of anti-T. gondii antibodies in the receptor is rarely performed. In the first study, we investigated the usefulness of detecting anti-T. gondii IgA for the diagnosis of an acute acquired Toxoplasma infection. Our results showed that anti-T. gondii IgA antibodies are detected with a high frequency in serum samples obtained from women with clinical and/or serologic evidence of acute acquired Toxoplasma infection. However, in 19% of the women presenting a sustained IgM antibody response and a high IgG avidity index, anti-T. gondii IgA antibodies were detected in serum samples collected more than nine months after the beginning of infection, indicating that IgA cannot be considered a dependable marker for acute primary infection. In the second study, we report the diagnosis of a primary toxoplasmic infection in a patient with multiple myeloma following a non-myeloablative allogeneic transplant with hematopoietic stem cells from a donor with negative serology for toxoplasmosis. The primary response to T. gondii was supported by IgM, IgG and IgA seroconversion. The patient was promptly treated and there were no complications related to toxoplasmosis in the subsequent months. This case stresses the importance of detecting anti-T. gondii antibodies in the donor and in the recipient before transplantation, and of serologically monitoring the recipient during long-term follow-u
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Ciencias Biomedicas
Mestre em Ciências Médicas
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Kamata, Tadashi. "Increased frequency of suldace IgA-Positive Plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA(HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA." Kyoto University, 2000. http://hdl.handle.net/2433/151436.

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Books on the topic "IgA"

1

Iga Ueno Kankō Kyōkai. "Igaguri" Henshūbu. Iga marugoto gaidobukku, Igabito: Iga marugoto guide book, Iga-bito. [Japan]: 2004 Igabito Iinkai, 2005.

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Bradwell, A. R. IgG and IgA subclasses in disease. Birmingham: Binding Site, 1995.

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Iga Tanimoto Kōsei: Chatō Iga chūshō tōga. Japan]: [publisher not identified], 1985.

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Clarkson, Anthony R., ed. IgA Nephropathy. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2039-5.

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R, Clarkson A., ed. IgA nephropathy. Boston: Nijhoff, 1987.

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(Japan), Iga-chō. Iga chōshi. Mie-ken Ayama-gun Iga-chō: Iga Machiyakuba, 2004.

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Iga ninpōchō. Tōkyō: Fujimi Shobō, 1990.

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International Symposium on IgA Nephropathy (11th 2006 Tokyo, Japan). IgA nephropathy today. Edited by Tomino Yasuhiko 1949-. Basel: Karger, 2007.

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Kankōkai, Iga Kobunken, ed. Iga kyūkō, Iranki. Mie-ken Iga-shi: Iga-shi Ueno Toshokan, 2006.

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Iga no Kagemaru. Tōkyō: Kabushiki Kaisha Shōgakkan Kurieitibu, 2011.

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Book chapters on the topic "IgA"

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Poslussny, P., K. Vinzenz, and F. Zekert. "Serumimmunglobuline (IgA, IgE, IgG, IgM) bei Patienten mit Kopf-Halskarzinomen." In Chirurgische Therapie von Kopf-Hals-Karzinomen, 335–42. Vienna: Springer Vienna, 1992. http://dx.doi.org/10.1007/978-3-7091-9087-6_39.

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Gooch, Jan W. "IgA." In Encyclopedic Dictionary of Polymers, 900. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13974.

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Suzuki, Hitoshi, Zina Moldoveanu, Stacy Hall, Rhubell Brown, Bruce A. Julian, Robert J. Wyatt, Milan Tomana, Yasuhiko Tomino, Jan Novak, and Jiri Mestecky. "IgA Nephropathy: Characterization of IgG Antibodies Specific for Galactose-Deficient IgA1." In IgA Nephropathy Today, 129–33. Basel: KARGER, 2007. http://dx.doi.org/10.1159/000102454.

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Allen, Alice, and John Feehally. "IgA Glycosylation in IgA Nephropathy." In Advances in Experimental Medicine and Biology, 175–83. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5383-0_17.

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Selvaskandan, Haresh, Chee Kay Cheung, and Jonathan Barratt. "IgA Nephropathy and IgA Vasculitis." In Primer on Nephrology, 451–65. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-76419-7_24.

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Cabanne, Charlotte, and Xavier Santarelli. "PURIFICATION OF IgM and IgA." In Process Scale Purification of Antibodies, 615–29. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119126942.ch28.

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Latov, Norman. "Nonmaligmant IgG and IgA Gammopathies." In Topics in the Neurosciences, 73–76. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2065-4_5.

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Tomana, M., B. A. Julian, F. B. Waldo, R. Kulhavy, and J. Mestecky. "IgA Nephropathy." In Advances in Experimental Medicine and Biology, 221. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1885-3_23.

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Coppo, Rosanna. "IgA Nephropathy." In Textbook of Clinical Pediatrics, 2749–55. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-02202-9_294.

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Watts, Richard A., David G. I. Scott, and Chetan Mukhtyar. "IgA Vasculitis." In Vasculitis in Clinical Practice, 127–37. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14871-7_12.

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Conference papers on the topic "IgA"

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Chekanova, T. A. "LABORATORY CONFIRMATION OF THE SPOTTED FEVER GROUP RICKETTSIOSES AMONG PATIENTS WITH TYPICAL AND ATYPICAL CLINICAL MANIFESTATIONS." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-81.

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In the group of patients with typical clinical signs of acute tick-borne rickettsioses, specific IgM and/or IgG with/without IgA were found in 75.6% cases. IgG were low avidity in most cases, which indicated the recent primary infection. More than 20% of sera have single group specific IgA. In patients with atypical manifestations highly avidity IgG were predominant, that along with the presence of IgM and/or IgA may indicate re-infection or infection by new species, which is different from previous pathogen of the tick-borne spotted group rickettsioses.
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Pedrosa, Lara Alípio, ARIANA LACERDA GARCIA, and BEATRIZ RIBEIRO COUTINHO DE MENDONÇA FURTADO. "OS BENEFÍCIOS DO ALEITAMENTO MATERNO NO SISTEMA IMUNOLÓGICO." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6018.

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Introdução: A Organização Mundial de Saúde (OMS), o Fundo das Nações Unidas para a Infância (UNICEF) e o Ministério da Saúde (MS) preconizam o aleitamento materno exclusivo até os seis meses de idade. Ao nascimento, a criança apresenta baixos níveis de imunoglobulinas (IgM, IgA e IgE). No entanto, o leite materno apresenta uma importante função na transferência de imunidade passiva no período pós-natal, pois possui funções antimicrobianas, anti-inflamatórias e imunorreguladoras. Nos primeiros três anos de vida, o .aleitamento materno exerce efeito benéfico sobre a incidência de eczema, alergia alimentar, sensibilização atópica e “doença sibilante”. Objetivo: Destacar a importância do aleitamento materno e os seus benefícios no sistema imunológico do recém-nascido. Metodologia: Esta revisão bibliográfica trata-se de um estudo qualitativo de artigos seletivos publicados em sites específicos, como BVS, Scielo e Pubmed, acerca da reflexão do impacto imunológico benéfico pelo aleitamento materno. Resultados: : O aleitamento materno protege o lactente de infecções principalmente por meio dos anticorpos IgA secretores (IgAS), além de fatores bioativos. A proteção contra infecções tem sido bem evidenciada durante a lactação, combatendo infecções do trato respiratório, incluindo otite média, infecção do trato urinário, sepse neonatal e enterocolite necrosante, diarreia aguda e prolongada, ganhando relação com o sistema imunológico do lactente pelas propriedades do leite materno, que, em especial o colostro, apresenta elevadas concentrações de anticorpos (IgA, IgM, IgE e IgD), sendo um reforço natural imunológico de destaque. Outra característica imunizante do leite materno é a presença de células polimorfonucleares (macrófagos, neutrófilos e eosinófilos) que fagocitam microrganismos patogênicos. Há ainda a presença de substâncias com propriedades probióticas e antibióticas como a lisozima, lactoferrina e o fator bífido que combatem a instalação de agentes envolvidos na etiologia de doenças diarreicas. Conclusão: Entende-se, portanto, a necessidade de se estimular o aleitamento materno durante o primeiro semestre de vida, período em que a produção própria de IgA secretória é ainda pouco significativa. O baixo teor de alérgenos no leite materno, bem como as propriedades anti-inflamatórias e imunomoduladoras, devem prevenir alergias e promover o desenvolvimento de tolerância.
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Schinco, P. C., A. Fusaro, M. Bazzan, A. Pannocchia, A. Pileri, and G. Tamponi. "INTERFERENCE OF MONOCLONAL IMMUNOGLOBULINS ON PLATELETS AND WHOLE BLOOD AGGREGATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643195.

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We studied 31 patients with monoclonal gammopathy (MG), 10 of them secreting monoclonal antibodies (MoAb) of the G class, 13 of them IgM and 8 IgA. We also studied 15 healthy age- and sex-matched control subjects. On each subject we evaluated whole blood aggregation (WBA) in response to ADP, collagen, epinephrine and arachidonic acid in parallel with PRP aggregation according to the method of Born. We wondered whether WBA could provide us further information on the interference of MoAb on platelet function. Agonists and concentrations which yielded statistically significant results in comparison with controls will be reported.IgM MG: Increased WBA to epinephrine 5 and 10 μM (p < 0.01) and ADP 4 and 6 μM (p < 0.001). Increased PRP aggregation to ADP 1 μM (p < 0.001) and collagen 1 μg/ml (p < 0.001).IgA MG: increased WBA to ADP 1 μM (p < 0.001). No difference in PRP aggregation.IgG MG: no difference in WBA. Reduced PRP aggregation in response to ADP 1 μM (p < 0.01) and arachidonic acid 0.5 mM (p < 0.01).We conclude that high molecular weight Ig (IgM pentamers and IgA dimers) seem to play a role in WBA, causing an increased aggregatory response when measured as impedance variation; on the other hand, low molecular weight Ig (IgG) seem to interfere directly with platelet function, causing a decreased aggregation. The mechanism underlying this phenomenon is still unclear.Supported by Grant n° 13 by Regione Piemonte.
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De Oliveira, Laríssa Santos De Oliveira, Bianca Caroline Ferreira, and Adriana Piccinin. "PROPRIEDADES IMUNIZANTES DO LEITE MATERNO E SEUS BENEFÍCIOS NA PREVENÇÃO DE DOENÇAS ALÉRGICAS." In I Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/942.

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Introdução: O termo “alergia” foi criado pelo pediatra australiano Clemens von Pirquet no começo do século XX. A definição sofreu modificações ao longo dos anos e hoje é interpretada como uma alteração do sistema imunológico levando a hipersensibilidade sintomática. Dessa maneira, uma alergia envolve uma resposta imunológica contra determinados antígenos presentes no meio ambiente. Essa resposta é o resultado de uma produção exagerada de IgE específico para esse alérgeno. Ao nascimento a criança apresenta baixos níveis de imunoglobulinas (IgM, IgA e IgE). No entanto, o leite materno apresenta uma importante função na transferência de imunidade passiva no período pós-natal, pois possui funções antimicrobianas, anti-inflamatórias e imunorreguladoras. Objetivo: Destacar a importância do aleitamento materno e os seus benefícios no sistema imunológico do recém-nascido contra alergias. Material e método: Este estudo trata-se de uma revisão bibliográfica e as bases de dados utilizadas foram Scielo e PubMed. Resultados: A Organização Mundial de Saúde (OMS), o Fundo das Nações Unidas para a Infância (UNICEF) e o Ministério da Saúde (MS) preconizam o aleitamento materno exclusivo até os seis meses de idade. Após esse período a recomendação é que recebam alimentos complementares, mas continuem com o aleitamento até dois anos. Trabalhos relatam que nos primeiros três anos de vida, o aleitamento natural exerce efeito benéfico sobre a incidência de eczema, alergia alimentar, sensibilização atópica e “doença sibilante”. No contexto da imunologia e da fisiologia, os discursos que respaldam as propriedades benéficas do leite materno, afirmam que este, especialmente o colostro, apresenta elevadas concentrações de anticorpos (IgA, IgM, IgE e IgD). Outra característica imunizante do leite materno é a presença de células polimorfonucleares (macrófagos, neutrófilos e eosinófilos) que fagocitam microrganismos patogênicos. Há ainda a presença de substâncias com propriedades probióticas e antibióticas como a lisozima, lactoferrina e o fator bífido que combatem a instalação de agentes envolvidos na etiologia de doenças diarreicas. Conclusão: O baixo teor de alérgenos no leite materno, bem como as propriedades anti-inflamatórias e imunomoduladoras, devem prevenir alergias e promover o desenvolvimento de tolerância. Além disso, sabe-se que as crianças amamentadas ficam menos doentes, necessitando menos de atendimento médico, hospitalizações e medicamentos.
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Maślińska, Maria, Joanna Dmowska-Chalaba, Małgorzata Mańczak, Long Shen, Lakshmanan Suresh, and Brygida Kwiatkowska. "FRI0245 RHEUMATOID FACTOR IN IGA, IGG AND IGM IMMUNOGLOBULIN CLASES IN PRIMARY SJöGREN’S SYNDROME." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.6365.

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Lima, Maria Eduarda Barbosa Camilo de, EDILAYNE SILVA DE ALMEIDA, ERICA CAVALCANTE VIEIRA DE GOIS, LUCIANA GESIELLI RODRIGUES ROCHA, and MARIA EDUARDA BARBOSA CAMILO DE LIMA. "IMPORTÂNCIA DO ALEITAMENTO MATERNO NO DESENVOLVIMENTO IMUNOLÓGICO DO RECÉM NASCIDO." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6324.

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Introdução: O aleitamento materno fornece todos nutrientes necessários para o desenvolvimento físico, mental e afetivo do recém-nascido, além de estar diretamente ligado ao fortalecimento do sistema imunológico, sendo uma das estratégias mais conhecidas na prevenção de mortes infantis. Além de todos os nutrientes responsáveis pelo crescimento do bebe, o leite materno tem em sua composição células que atuam na defesa do organismo dele, como por exemplo imunoglobulinas que são glicoproteínas responsáveis pela imunidade. As imunoglobulinas presentes no leite materno são IgG, IgA, IgM, IgD e IgE, sendo mais presente o IgA. Apesar dos benefícios mencionados, nem toda mulher deseja ou tem a possibilidade de amamentar, devido a fatores fisiológicos, socioeconômicos ou culturais. Objetivo: Diante dessa problemática objetiva-se demonstrar a importância da amamentação para o desenvolvimento do sistema imunológico do recém-nascido por meio de evidencias cientificas. Material e métodos: A pesquisa será uma revisão integrativa de literatura, realizada por seis etapas: elaboração de pergunta norteadora, busca da literatura, coleta de dados, análise crítica dos estudos incluídos, discussão dos resultados e apresentação da revisão. A busca será realizada no Medical Literature Analysis and Retrieval System Online (MEDLINE), e Literatura Latino-Americana do Caribe em Ciências da Saúde (LILACS) por meio do Portal da Biblioteca Virtual em Saúde (BVS), através da combinação entre os descritores aleitamento materno and sistema imunológico and recém-nascido nos idiomas português e inglês. Serão considerados critérios de inclusão: artigos disponíveis em meio online, de livre acesso no idioma citados, entres os anos 2017 a 2022, que respondam à questão da pesquisa. Serão excluídos relatos de caso, revisões, monografias, dissertações, teses, editoriais e publicações ministeriais. A análise seguirá estrutura descritiva. Resultados: Dentre os resultados obtidos foi perceptível que o aleitamento materno protege o recém-nascido de várias enfermidades como por exemplo das doenças respiratórias, gastrointestinais, infecções alergias, doenças autoimunes, reveste a mucosa intestinal e reduz o índice de mortalidade infantil. Conclusão: Tendo em vista todos os benefícios nutricionais e imunológicos, o aleitamento materno exclusivo é de suma importância e deve ser incentivado até o quarto ou sexto mês de vida do bebe visando a proteção e crescimento do mesmo.
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Hitoo, Iwase, Nakamura Ikuko, Kenji Arai, Yoko Nagai, Kazunori Toma, Tadashi Katsumata, Takashi Sano, and Yutaka Kobayashi. "GENDER DIFFERENCE AND EPITOPE SPECIFICITY OF IGG ANTIBODY AGAINST IGA1 HINGE PORTION IN IGA NEPHROPATHY PATIENTS." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.666.

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Paixão, Vitória da, Tamaris Roseira, Jônatas Bussador Do Amaral, Juliana De Melo Batista Dos Santos, and André Luis Lacerda Bachi. "IDOSOS SUPLEMENTADOS COM L-GLUTAMINA TEM MELHOR RESPOSTA DE MUCOSA E NÃO SÉRICA À VACINA PARA O VIRUS INFLUENZA." In II Congresso Brasileiro de Saúde On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1448.

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Introdução: Embora a suplementação com glutamina tenha mostrado diversos benefícios na imunidade, à ação deste aminoácido na resposta imune das vias aéreas superiores, especialmente em idosos, ainda necessita de esclarecimentos. Em relação à resposta imune em idosos, é amplamente aceito que durante o envelhecimento há evidente diminuição das atividades imunológicas, um fenômeno denominado de imunossenescência, o qual leva os idosos a apresentarem uma menor capacidade de se protegerem contra infecções e também de responder à imunização. Objetivo: Diante destas informações, neste estudo objetivamos avaliar o efeito da suplementação de L-glutamina nos níveis da imunoglobulina A (IgA) tanto sérica quanto na mucosa das vias aéreas de idosos vacinados para o vírus Influenza. Métodos: Foram coletadas amostras de sangue e saliva de 83 idosos fisicamente ativos, em dois momentos, antes (pré) e 30 dias após a vacinação para o vírus Influenza e suplementação com L-glutamina (Gln, n = 42) ou placebo (PL, n = 41) para avaliação dos níveis da imunoglobulina A (IgA). Resultados: Maiores níveis séricos de IgA foram observados em ambos os grupos pós-vacinação quando comparado aos valores pré-vacinação. Em relação à reposta de mucosa, foi evidenciado níveis salivares mais altos de IgA secretora (IgAs), tanto total quanto específica para a vacina, foram encontrados pós-vacinação no grupo Gln em comparação aos valores observados pré-vacinação e no grupo PL pós-vacinação. Conclusão: Diante dos resultados obtidos, pode-se concluir que a suplementação de Gln é capaz de melhorar a resposta à vacinação contra o vírus Influenza em idosos através de uma modulação da resposta imune na mucosa, pois induz a produção e liberação de IgAs, o que confere maior proteção à mucosa.
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Akbiek, M., A. Hadeh, A. Daya, A. Gandhi, and K. Patel. "Selective IgA Deficiency and Bronchiectasis." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6389.

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Köhler-Vajita, K., L. Grütler, and F. Bidlingmaier. "Immunoglobulins of HIV positive and negative haemophiliac children treated with different concentrates." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644138.

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Aim of this investigation is the quantitative comparison of theimmunoglobulins G, A, M in haemophiliac children treated with different types of factor VIII concentrates.Patients and methodsSince May 1984 22 patients with haemophiliaA were investigated. Instead of the more often analysed parameterof the cellular immunity now we want to draw the attention to the immunoglobuline values, especiallyof the HIV negative group of patients treated exclusively with Haemate HS Behringwerke in comparison with other differently treated HIV positive and negative patients.Results The group of patients treated exclusively with Haemate HS Behringwerke (in solution heatsterilized) shows completely normal immunolobuline levels and a safe HIV negativity.Patients treated with conventional, later with heat treated (inlyophilized form) concentrates can be divided into HIV positive and negative groups. HIV positive heamophiliacs show pathological IgG and border line IgA and IgM values. HIV negative patients have IgG, A levels within the normal limits -but clearly higher than the Haemate group. A correlation withliver enzyme status (hepatitis B, NANB) could not be found.
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Reports on the topic "IgA"

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Tota, Maciej, Vanessa Baron, Bouchra Derrough, Katie Musial, Andrzej Konieczny, Magdalena Krajewska, Kültigin Türkmen, and Mariusz Kusztal. Secondary IgA Nephropathy without IgA vasculitis: a systematic review of case reports. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2023. http://dx.doi.org/10.37766/inplasy2023.2.0022.

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Ivy, John M. Production of Anti-Ferret IgA Antibodies; and production of monoclonal antibodies. Fort Belvoir, VA: Defense Technical Information Center, April 1994. http://dx.doi.org/10.21236/ada279534.

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He, Mingyu, Tianying Chang, and Shoulin Zhang. Efficacy and safety of Tripterygium wilfordii glycosides in treatment of IgA nephropathy：A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0037.

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Lumsden, Jessee. An Investigation of the Mechanism of IGA/SCC of Alloy 600 in Corrosion Accelerating Heated Crevice Environments. Technical Progress Report. Office of Scientific and Technical Information (OSTI), November 1999. http://dx.doi.org/10.2172/761827.

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Lumsden, Jesse. An Investigation of the Mechanism of IGA/SCC of Alloy 500 in Corrosion Accelerating Heated Crevice Environments. Technical progress report. Office of Scientific and Technical Information (OSTI), March 2000. http://dx.doi.org/10.2172/762168.

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Lumsden, Jesse. An Investigation of the Mechanism of IGA/SCC of Alloy 600 in Corrosion Accelerating Heated Crevice Environments. Technical Progress Report. Office of Scientific and Technical Information (OSTI), January 1999. http://dx.doi.org/10.2172/762745.

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Lv, Guangxin, and Chengyuan Ming. Efficacy and safety of leflunomide combined with corticosteroids for the treatment of IgA nephropathy: a meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0158.

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Dr. Jesse Lumsden. An Investigation of the Mechanism of IGA/SCC of Alloy 600 in Corrosion Accelerating Heated Crevice Environments - Topical Report Phase I 8/18/1999 - 8/31/2000. Office of Scientific and Technical Information (OSTI), November 2000. http://dx.doi.org/10.2172/769257.

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Jesse Lumsden. An Investigation of the Mechanism of IGA/SCC of Alloy 600 in Corrosion Accelerating Heated Crevice Environments: Topical Report - Results for Mod of Heated Crevice - 08/18/1999 - 08/31/2000. Office of Scientific and Technical Information (OSTI), November 2000. http://dx.doi.org/10.2172/769287.

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Dr. Jesse Lumsden. An investigation of the mechanism of IGA/SCC of alloy 600 in corrosion accelerating heated crevice environments. Quarterly Technical Progress Report No. 4 for the period May 1, 2000 through July 31, 2000. Office of Scientific and Technical Information (OSTI), July 2000. http://dx.doi.org/10.2172/765749.

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