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Author: Grafiati

Published: 10 March 2023

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1

Pethusamy, Karthikeyan, Ashikh A. Seethy, Maheshwari Kulandhasamy, Pinki Garg, Debashish Chowdhury, Sarita Agarwal, Arun Kumar, Ruby Dhar, and Subhradip Karmakar. "Effects of 469 E/K polymorphism of ICAM1 gene in ischemic stroke and its association with stroke severity and outcome." Asian Journal of Medical Sciences 12, no. 1 (January 1, 2021): 2–7. http://dx.doi.org/10.3126/ajms.v12i1.30985.

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Background: Stroke is the second leading cause of death globally and it is a major cause of long-term, physical, psychological, and social disability among the elderly. Increasing evidence shows that ischemic injury and inflammation account for its pathogenic progression. So, we studied the association of Intercellular Adhesion Molecule 1 (ICAM1) polymorphism with ischemic stroke, stroke severity, and outcome. Aims and Objectives: To compare ICAM1 469 E/K polymorphism in ischemic stroke patients with healthy controls, and to study its association with stroke severity and outcome. Materials and Methods: Fifty patients of ischemic stroke and hundred healthy individuals were included. The stroke severity was assessed clinically and radiologically. Outcome was measured at three and six months of stroke onset. Genomic DNA was used for Allele-Specific PCR to detect ICAM1 469 E/K polymorphism. The subjects were categorized into EE, EK, and KK genotypes. Results: The odds of EK genotype to develop stroke was 0.41 (95 % CI; 0.17 - 0.92) (p = 0.07) and of KK genotype was 0.41 (95 % CI; 0.11 - 0.87) (p = 0.04) compared to EE genotype. Subjects with ICAM1K allele had significantly reduced risk of stroke compared with those with E allele. (RR: 0.55; 95% CI: 0.35-0.87) (p=0.03). Conclusion: Subjects with ICAM1K allele had significantly reduced the risk of developing stroke. 469 E/K polymorphism of the ICAM1 gene does not significantly affect stroke severity, mortality, and outcome.

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2

Goddard, Chris. "Not the Last Word: Point and Counter-Point: The Discovery of Affluenza and the Favelas Above: A Rising Tide Brings the End of Dry Economics." Children Australia 14, no. 3 (1989): 16–17. http://dx.doi.org/10.1017/s0312897000002320.

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There is a Yorkshire expression, that many people are fond of quoting, to account for strange behaviour: “There's nowt so queer as folk”. Some folk, always other folk and never oneself, are more queer than others (and many Englishmen would claim that Yorkshire folk are stranger than most, but that's another story).The expression came to mind when I read a column in Icaro, the magazine of Varig, the Brazilian airline. I am not fond of flying at the st of times and finding a magazine called Icaro in the seat pocket of a fully-laden jet increased my anxiety. Icaro, presumably, is Portuguese for that legendary character Icarus who, in attempting to escape from Crete, flew so high that the sun melted the wax that held his wings on with the consequence that he fell in the sea. A stranger title for an airline magazine would be hard to find.

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3

Callicott, Christina. "Communication interspécifique en Amazonie occidentale : la musique comme forme de conversation entre les plantes et les humains." Cygne noir, no. 5 (June 16, 2022): 58–73. http://dx.doi.org/10.7202/1089939ar.

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Chez les peuples autochtones d’Amazonie occidentale, où les cosmologies animistes constituent la norme, les relations entre les humains et les non-humains sont médiées par des formes de communication variées. Dans cet article, j’examine un type de musique chamanique propre aux communautés autochtones et métisses d’Amazonie occidentale appelé icaro. Partant d’exemples empruntés aux études ethnographiques, j’examine la manière dont ces chansons chamaniques sont acquises et utilisées pour communiquer avec des esprits et pour réaliser des changements dans le monde matériel. Puis, je convoque la phytosémiotique en conjonction avec les recherches récentes sur la communication chez les plantes pour montrer comment le processus de l’apprentissage chamanique et l’acquisition des icaros relèvent d’une communication interspécifique, au sens où l’apprenti intercepte et interprète les signaux phytochimiques inhérents au processus de communication des plantes.

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4

Gloviczki, Zoltán. "Icarus." Acta Antiqua Academiae Scientiarum Hungaricae 42, no. 1-4 (October 2002): 147–56. http://dx.doi.org/10.1556/aant.42.2002.1-4.13.

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5

Green, William H. "Icarus." Chicago Review 34, no. 4 (1985): 64. http://dx.doi.org/10.2307/25305292.

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6

Onim, Gail O. "Icarus." Psychological Perspectives 18, no. 2 (September 1987): 408–9. http://dx.doi.org/10.1080/00332928708410870.

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7

Gardner, P. "Icarus." English 39, no. 164 (June 1, 1990): 148. http://dx.doi.org/10.1093/english/39.164.148.

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8

Rahman, Protiva, Courtney Hebert, and Arnab Nandi. "ICARUS." Proceedings of the VLDB Endowment 11, no. 13 (September 1, 2018): 2263–76. http://dx.doi.org/10.14778/3275366.3275374.

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9

Rahman, Protiva, Courtney Hebert, and Arnab Nandi. "ICARUS." Proceedings of the VLDB Endowment 11, no. 13 (September 2018): 2263–76. http://dx.doi.org/10.14778/3275366.3284970.

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10

Yawar, Athar. "Icarus." Lancet 390, no. 10112 (December 2017): 2543–44. http://dx.doi.org/10.1016/s0140-6736(17)33092-1.

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11

Gloviczki, Zoltán. "Icarus." Antik Tanulmányok 46, no. 1-2 (June 1, 2002): 109–17. http://dx.doi.org/10.1556/anttan.46.2002.1-2.8.

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Pygmalion és Arachne figuráját Ovidius paradigmatikus művészábrázolásaként tartjuk számon. Magától értetődne a Metamorphoses VIII. énekében szereplő Daedalus-epizód hasonló értelmezése. A részlet elemzése és összehasonlítása a téma Ars Amatoria-beli feldolgozásával ugyanakkor egyértelművé teszik, hogy a későbbi változat középpontjába az archetipikus Daedalus helyett Icarus alakja kerül. Ő jeleníti meg egyúttal az ovidiusi költőideál számos markáns vonását: meghatározva szerzőnk viszonyát a közönséghez, az idejét múlt vagy éppen kisszerűnek tartott művészi magatartásformákhoz, saját költői ambíciói beteljesülhetetlenségéhez.

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12

Rao, Chaolin, Huangjie Yu, Haochuan Wan, Jindong Zhou, Yueyang Zheng, Minye Wu, Yu Ma, et al. "ICARUS." ACM Transactions on Graphics 41, no. 6 (November 30, 2022): 1–14. http://dx.doi.org/10.1145/3550454.3555505.

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The practical deployment of Neural Radiance Fields (NeRF) in rendering applications faces several challenges, with the most critical one being low rendering speed on even high-end graphic processing units (GPUs). In this paper, we present ICARUS, a specialized accelerator architecture tailored for NeRF rendering. Unlike GPUs using general purpose computing and memory architectures for NeRF, ICARUS executes the complete NeRF pipeline using dedicated plenoptic cores (PLCore) consisting of a positional encoding unit (PEU), a multi-layer perceptron (MLP) engine, and a volume rendering unit (VRU). A PLCore takes in positions & directions and renders the corresponding pixel colors without any intermediate data going off-chip for temporary storage and exchange, which can be time and power consuming. To implement the most expensive component of NeRF, i.e., the MLP, we transform the fully connected operations to approximated reconfigurable multiple constant multiplications (MCMs), where common subexpressions are shared across different multiplications to improve the computation efficiency. We build a prototype ICARUS using Synopsys HAPS-80 S104, a field programmable gate array (FPGA)-based prototyping system for large-scale integrated circuits and systems design. We evaluate the power-performancearea (PPA) of a PLCore using 40nm LP CMOS technology. Working at 400 MHz, a single PLCore occupies 16.5 mm 2 and consumes 282.8 mW, translating to 0.105 uJ/sample. The results are compared with those of GPU and tensor processing unit (TPU) implementations.

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13

Kawakatsu, Kenichi. "ICARDA and Water Harvesting." Journal of Rainwater Catchment Systems 10, no. 2 (2005): 19–22. http://dx.doi.org/10.7132/jrcsa.kj00004364657.

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Gu, Xingjian, Dongyang He, Caixin Li, Hua Wang, and Guanghua Yang. "Development of Inducible CD19-CAR T Cells with a Tet-On System for Controlled Activity and Enhanced Clinical Safety." International Journal of Molecular Sciences 19, no. 11 (November 3, 2018): 3455. http://dx.doi.org/10.3390/ijms19113455.

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The tetracycline regulatory system has been widely used to control the transgene expression. With this powerful tool, it might be possible to effectively control the functional activity of chimeric antigen receptor (CAR) T cells and manage the severe side effects after infusion. In this study, we developed novel inducible CD19CAR (iCAR19) T cells by incorporating a one-vector Tet-on system into the CD19CAR construct. The iCAR19 T cells showed dox-dependent cell proliferation, cytokine production, CAR expression, and strong CD19-specific cytotoxicity. After 48 h of dox induction, the relative CAR expression of induced cells was five times greater than that of uninduced cells. Twenty-four hours after dox removal, CAR expression significantly decreased by more than 60%. In cytotoxicity assays, dox-treated cells induced significantly higher specific lysis against target cells. These results suggested that the activity of iCAR19 T cells was successfully controlled by our Tet-on system, offering an enhanced safety profile while maintaining a robust anti-tumor effect. Besides, all manufacture processes of the lentiviral vectors and the T cells were conducted according to the Good Manufacturing Practice (GMP) standards for subsequent clinical translation.

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15

Torkko, Juha M., M. Evangelina Primo, Ronald Dirkx, Anne Friedrich, Antje Viehrig, Elisa Vergari, Barbara Borgonovo, et al. "Stability of proICA512/IA-2 and Its Targeting to Insulin Secretory Granules Require β4-Sheet-Mediated Dimerization of Its Ectodomain in the Endoplasmic Reticulum." Molecular and Cellular Biology 35, no. 6 (January 5, 2015): 914–27. http://dx.doi.org/10.1128/mcb.00994-14.

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The type 1 diabetes autoantigen ICA512/IA-2/RPTPN is a receptor protein tyrosine phosphatase of the insulin secretory granules (SGs) which regulates the size of granule stores, possibly via cleavage/signaling of its cytosolic tail. The role of its extracellular region remains unknown. Structural studies indicated that β2- or β4-strands in the mature ectodomain (ME ICA512) form dimers in vitro . Here we show that ME ICA512 prompts proICA512 dimerization in the endoplasmic reticulum. Perturbation of ME ICA512 β2-strand N-glycosylation upon S508A replacement allows for proICA512 dimerization, O -glycosylation, targeting to granules, and conversion, which are instead precluded upon G553D replacement in the ME ICA512 β4-strand. S508A/G553D and N506A/G553D double mutants dimerize but remain in the endoplasmic reticulum. Removal of the N-terminal fragment (ICA512-NTF) preceding ME ICA512 allows an ICA512-ΔNTF G553D mutant to exit the endoplasmic reticulum, and ICA512-ΔNTF is constitutively delivered to the cell surface. The signal for SG sorting is located within the NTF RESP18 homology domain (RESP18-HD), whereas soluble NTF is retained in the endoplasmic reticulum. Hence, we propose that the ME ICA512 β2-strand fosters proICA512 dimerization until NTF prevents N506 glycosylation. Removal of this constraint allows for proICA512 β4-strand-induced dimerization, exit from the endoplasmic reticulum, O -glycosylation, and RESP18-HD-mediated targeting to granules.

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16

Revol, Jean, and R. Scott Walker. "Icarus Estranged." Diogenes 35, no. 140 (December 1987): 70–92. http://dx.doi.org/10.1177/039219218703514004.

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17

McEnery Shorvon, Kate. "Icarus Returned." Textual Practice 29, no. 1 (January 2, 2015): 37–39. http://dx.doi.org/10.1080/0950236x.2014.997021.

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18

Webb, Richard. "Mission Icarus." New Scientist 237, no. 3171 (March 2018): 37–41. http://dx.doi.org/10.1016/s0262-4079(18)30575-x.

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19

Nolan, Tom. "California Icarus." American Book Review 29, no. 4 (2008): 20–21. http://dx.doi.org/10.1353/abr.2008.0057.

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20

Chartrain, Alexander G., Danny Hom, Joshua B. Bederson, J. Mocco, and Christopher Paul Kellner. "Republished: Intracavitary ultrasound (ICARUS): a neuroendoscopic adaptation of intravascular ultrasound for intracerebral hemorrhage evacuation." Journal of NeuroInterventional Surgery 10, no. 7 (March 21, 2018): e16-e16. http://dx.doi.org/10.1136/neurintsurg-2017-013188.rep.

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Neurosurgeons performing intracerebral hemorrhage evacuation procedures have limited options for monitoring hematoma evacuation and assessing residual hematoma burden intraoperatively. Here, we report the successful neuroendoscopic adaptation of intravascular ultrasound, referred to here as intracavitary ultrasound (ICARUS), in two patients. Pre-evacuation ICARUS demonstrated dense hematomas in both patients. Post-evacuation ICARUS in patient 1 demonstrated significant reduction in clot burden and two focal hyperechoic regions consistent with pockets of hematoma not previously seen with the endoscope or burr hole ultrasound. These areas were directly targeted and resected with the endoscope and suction device. Post-evacuation ICARUS in patient 2 showed significant reduction of hematoma volume without indication of residual blood. ICARUS findings were confirmed on intraoperative DynaCT and postoperative CT 24 hours later. ICARUS is feasibly performed in a hematoma cavity both before and after hematoma aspiration. ICARUS may provide additional information to the operating surgeon and assist in maximizing hematoma removal.

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21

De Geuser, Frédéric, Alexis Deschamps, Jean-Christophe Ehrström, Philippe Jarry, Georges Salloum-Abou-Jaoude, Luc Salvo, and Christophe Sigli. "17th International Conference on Aluminium Alloys – ICAA17." MATEC Web of Conferences 326 (2020): 00001. http://dx.doi.org/10.1051/matecconf/202032600001.

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22

Young, Stephanie R., and Timothy Z. Keith. "An Examination of the Convergent Validity of the ICAR16 and WAIS-IV." Journal of Psychoeducational Assessment 38, no. 8 (July 23, 2020): 1052–59. http://dx.doi.org/10.1177/0734282920943455.

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The construct validity of the International Cognitive Ability Resource (ICAR) has yet to be investigated using a gold-standard individually administered intelligence battery. The present study used a convenience sample of 97 students to examine the respective relations between the ICAR16 and overall intelligence ( g) and the Cattell–Horn–Carroll broad abilities measured by the WAIS-IV. Large correlations were observed between the observed overall scores (rICAR16, full-scale IQ = .81, p < .001) and the CFA-estimated general factors ( r = .94, p < .001). Evidence from confirmatory factor models suggests that the ICAR letter–number Series task measures fluid reasoning, while the matrix reasoning, verbal reasoning, and three-dimensional reasoning tasks measure visual–spatial reasoning (Gv). Findings support the ICAR16 as a valid brief measure of nonverbal intelligence; however, replications in larger samples are needed.

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23

Parastuti, Niken Rara Galih Amithya, and Endang Soegiartini. "Yarkovsky Effect on the Orbital Dynamics of 1566 Icarus Asteroid." Indonesian Journal of Physics 30, no. 1 (January 16, 2019): 6–13. http://dx.doi.org/10.5614/itb.ijp.2019.30.1.2.

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The orbital dynamic of small objects is an n-body problem that can not be solve by analitically, it is needed to use numerical integration to find the solution instead. This work is about orbital dynamic of asteroid 1566 Icarus under Classical Newtonian gravitation and if thermal effect (Yarkovsky effect) is included. Yarkovsky Effect is a thermal radiation force resulted from time span of small rotating objects to receive heat from the Sun and then re-radiates it. The Yarkovsky Effect is working optimum for objects with diameter from 10 cm up to 10 km, and now is implemented to Asteroid 1566 Icarus with diameter 1.3 km which are member of Apollo and Earth crosser object. This Asteroid is called Earth crosser due to its orbit is crossing Earth’s orbit. With semi major axis a  1.078 au and eccentricity e  0.827, asteroid 1566 Icarus has perihelion distance q = 0.18674 au or less than semi major axis of Mercury. Due to that reason, Yarkovsky effect was considered to be applied on the orbital dynamics of asteroid 1566 Icarus. Due to sensitivity in input-data of numerical integration for n-body, one hundred simulation preliminary data were made as input in numerical integration process, therefore, 100 clones of Asteroid 1566 Icarus are gathered. Cloning process was conducted by using random number from Asteroid 1566 Icarus orbital elements at epoch 2456800.5 (23 May 2014) to standard deviation . The integration then later conducted within 105 years time span from the epoch. The result shown that the orbital dynamics of asteroid 1566 Icarus with Yarkovsky effect is still within the range of 100 clones of asteroid 1566 Icarus. Thereby, within 105 years, Yarkovsky effect does not change the orbital dynamic of asteroid 1566 Icarus globally, except for two phenomenon between close encounter with planet.

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24

Burtseva, Natalia L. "ICARUS – A New Scientific Experiment on the ISS." Aerospace Sphere Journal 96, no. 3 (September 2018): 94–99. http://dx.doi.org/10.30981/2587-7992-2018-99-3-94-99.

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25

Steller, H., and V. Pirrotta. "P transposons controlled by the heat shock promoter." Molecular and Cellular Biology 6, no. 5 (May 1986): 1640–49. http://dx.doi.org/10.1128/mcb.6.5.1640-1649.1986.

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We have transformed Drosophila melanogaster with modified P-element transposons, which express the transposase function from the heat-inducible hsp70 heat shock promoter. The Icarus transposon, which contains a direct hsp70-P fusion gene, behaved like a very active autonomous P element even before heat shock induction. Although heat shock led to abundant somatic transcription, transposition of the Icarus element was confined to germ line cells. To reduce the constitutive transposase activity observed for the Icarus element, we attenuated the translational efficiency of the transposase RNA by inserting the transposon 5 neomycin resistance gene between the hsp70 promoter and the P-element sequences. The resulting construct, called Icarus-neo, conferred resistance to G418, and its transposition was significantly stimulated by heat shock. Heat shocks applied during the embryonic or third instar larval stage had similar effects, indicating that transposition of P elements is not restricted to a certain developmental stage. Both Icarus and Icarus-neo destabilized snw in a P-cytotype background and thus at least partially overcome the repression of transposition. Our results suggest that the regulation of P-element transposition occurs at both the transcriptional and posttranscriptional levels.

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Steller, H., and V. Pirrotta. "P transposons controlled by the heat shock promoter." Molecular and Cellular Biology 6, no. 5 (May 1986): 1640–49. http://dx.doi.org/10.1128/mcb.6.5.1640.

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We have transformed Drosophila melanogaster with modified P-element transposons, which express the transposase function from the heat-inducible hsp70 heat shock promoter. The Icarus transposon, which contains a direct hsp70-P fusion gene, behaved like a very active autonomous P element even before heat shock induction. Although heat shock led to abundant somatic transcription, transposition of the Icarus element was confined to germ line cells. To reduce the constitutive transposase activity observed for the Icarus element, we attenuated the translational efficiency of the transposase RNA by inserting the transposon 5 neomycin resistance gene between the hsp70 promoter and the P-element sequences. The resulting construct, called Icarus-neo, conferred resistance to G418, and its transposition was significantly stimulated by heat shock. Heat shocks applied during the embryonic or third instar larval stage had similar effects, indicating that transposition of P elements is not restricted to a certain developmental stage. Both Icarus and Icarus-neo destabilized snw in a P-cytotype background and thus at least partially overcome the repression of transposition. Our results suggest that the regulation of P-element transposition occurs at both the transcriptional and posttranscriptional levels.

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27

Désormeaux, Monique. "Icare." L'en-je lacanien 38, no. 1 (May 18, 2022): 138. http://dx.doi.org/10.3917/enje.038.0138.

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28

Farnese, Christian, and on behalf of the ICARUS Collaboration. "The ICARUS Experiment." Universe 5, no. 2 (January 29, 2019): 49. http://dx.doi.org/10.3390/universe5020049.

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The 760-ton ICARUS T600 detector has completed a successful three-year physics run at the underground LNGS laboratories, searching for atmospheric neutrino interactions and, with the CNGS neutrino beam from CERN, performing a sensitive search for LSND-like anomalous ν e appearance, which contributed to constraining the allowed parameters to a narrow region around Δ m 2 ∼ eV 2 , where all the experimental results can be coherently accommodated at 90% C.L. The T600 detector underwent a significant overhaul at CERN and has now been moved to Fermilab, to be soon exposed to the Booster Neutrino Beam (BNB) to search for sterile neutrinos within the SBN program, devoted to definitively clarifying the open questions of the presently-observed neutrino anomalies. This paper will address ICARUS’s achievements, its status, and plans for the new run and the ongoing analyses, which will be finalized for the next physics run at Fermilab.

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29

Dufour, Philippe. "Complainte des Icares." Poétique 183, no. 1 (2018): 3. http://dx.doi.org/10.3917/poeti.183.0003.

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30

Yildirmaz, Kayra. "Tears of Icarus." Questions: Philosophy for Young People 22 (2022): 23. http://dx.doi.org/10.5840/questions20222215.

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31

Garno, Diana M. "Travels in Icaria." Utopian Studies 16, no. 1 (2005): 148–51. http://dx.doi.org/10.2307/20718728.

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Harison, Casey. "Citoyennes and Icaria." Utopian Studies 17, no. 2 (January 1, 2006): 420–23. http://dx.doi.org/10.2307/20718845.

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Garno, Diana M. "Travels in Icaria." Utopian Studies 16, no. 1 (2005): 148–51. http://dx.doi.org/10.5325/utopianstudies.16.1.0148.

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Harison, Casey. "Citoyennes and Icaria." Utopian Studies 17, no. 2 (January 1, 2006): 420–23. http://dx.doi.org/10.5325/utopianstudies.17.2.0420.

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35

Gianani, R., D. U. Rabin, C. F. Verge, L. Yu, S. R. Babu, M. Pietropaolo, and G. S. Eisenbarth. "ICA512 Autoantibody Radioassay." Diabetes 44, no. 11 (November 1, 1995): 1340–44. http://dx.doi.org/10.2337/diab.44.11.1340.

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36

Strauss, Jonathan. "The Inverted Icarus." Yale French Studies, no. 78 (1990): 106. http://dx.doi.org/10.2307/2930118.

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37

MADOU, Marc. "Nanosensors: Icarus Revisited?" Electrochemistry 71, no. 6 (June 5, 2003): 385. http://dx.doi.org/10.5796/electrochemistry.71.385.

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38

Bloom, Nicholas. "The Federal Icarus." Journal of Urban History 28, no. 1 (November 2001): 55–71. http://dx.doi.org/10.1177/009614420102800103.

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39

Farnese, Christian. "The ICARUS experiment." EPJ Web of Conferences 182 (2018): 02042. http://dx.doi.org/10.1051/epjconf/201818202042.

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The 760 ton liquid argon ICARUS T600 detector performed a successful threeyear physics run at the underground LNGS laboratories, studying neutrino oscillations with the CNGS neutrino beam and searching for atmospheric neutrino interactions in cosmic rays. A sensitive search for LSND like anomalous ve appearance has been performed, contributing to constrain the allowed parameters to a narrow region around Δm2 ~ eV2, where all the experimental results can be coherently accommodated at 90% C.L.. After a significant overhauling, the T600 detector will be exposed at Fermilab to the Booster Neutrino Beam acting as the far detector, in order to search for sterile neutrino within the SBN program. In the present contribution, the ICARUS LNGS achievements, the present status of the detector and the ongoing analyses also finalized to the next physics run at Fermilab will be addressed.

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40

Tortorici, F., V. Bellini, C. Petta, and C. M. Sutera. "The ICARUS Experiment." Nuclear and Particle Physics Proceedings 306-308 (September 2019): 154–62. http://dx.doi.org/10.1016/j.nuclphysbps.2019.07.022.

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41

Arneodo, F. "MINOS, OPERA, ICARUS." Nuclear Physics B - Proceedings Supplements 138 (January 2005): 363–69. http://dx.doi.org/10.1016/j.nuclphysbps.2004.11.084.

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42

Bueno, A. "The ICARUS Project." Nuclear Physics B - Proceedings Supplements 143 (June 2005): 262–65. http://dx.doi.org/10.1016/j.nuclphysbps.2005.01.116.

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Guglielmi, A. "The ICARUS project." Nuclear Physics B - Proceedings Supplements 149 (December 2005): 143–46. http://dx.doi.org/10.1016/j.nuclphysbps.2005.05.029.

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44

Farnese, Christian. "NEUTRINOS FROM ICARUS." Acta Polytechnica 53, A (December 18, 2013): 776–81. http://dx.doi.org/10.14311/ap.2013.53.0776.

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Liquid Argon Time Projection Chambers are very promising detectors for neutrino and astroparticle physics due to their high granularity, good energy resolution and 3D imaging, allowing for a precise event reconstruction. ICARUS T600 is the largest liquid Argon (LAr) TPC detector ever built (~600 ton LAr mass) and is presently operating underground at the LNGS laboratory. This detector, internationally considered as the milestone towards the realization of the next generation of massive detectors (~tens of ktons) for neutrino and rare event physics, has been smoothly running since summer 2010, collecting data with the CNGS beam and with cosmics. The status of this detector will be shortly described together with the intent to adopt the LAr TPC technology at CERN as a possible solution to the sterile neutrino puzzle.

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45

Burns, Joseph A. "Icarus during 1985." Icarus 64, no. 3 (December 1985): 341–43. http://dx.doi.org/10.1016/0019-1035(85)90059-4.

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Gianani, R., D. U. Rabin, C. F. Verge, L. Yu, S. R. Babu, M. Pietropaolo, and G. S. Eisenbarth. "ICA512 autoantibody radioassay." Diabetes 44, no. 11 (November 1, 1995): 1340–44. http://dx.doi.org/10.2337/diabetes.44.11.1340.

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Wade, Robert. "Iceland as Icarus." Challenge 52, no. 3 (May 2009): 5–33. http://dx.doi.org/10.2753/0577-5132520301.

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Nicholson, Philip D. "Icarus publication times." Icarus 201, no. 2 (June 2009): 423. http://dx.doi.org/10.1016/j.icarus.2009.04.001.

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Behera, Biswaranjan. "Cosmogenic background suppression at the ICARUS using a concrete overburden." Journal of Physics: Conference Series 2156, no. 1 (December 1, 2021): 012181. http://dx.doi.org/10.1088/1742-6596/2156/1/012181.

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Abstract The ICARUS detector will search for LSND like neutrino oscillations exposed at shallow depth to the FNAL BNB beam in the context of the SBN program. In the approved FNAL SBN experiment the impact of cosmic rays is mitigated by a 4π Cosmic Ray Tagger (CRT) detector encapsulating the TPCs inside the pit and by a ∼ 3 m concrete overburden both for the near (SBND) and the far (ICARUS) detectors. Cosmic backgrounds rejection is particularly relevant for the ICARUS detector. Due to its larger size and distance from target compared to SBND, in ICARUS the neutrino signal/cosmic background ratio is 40 times more unfavorable with in addition a greater than 3 times larger out-of-spill comics rate. In this paper, I will be addressing the question of a problematic background to genuine neutrino events especially into the electron neutrino appearance analysis by a detailed MonteCarlo calculation of the cosmic rays crossing the ICARUS detector.

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Trajkovski, Mirko, Hassan Mziaut, Anke Altkrüger, Joke Ouwendijk, Klaus-Peter Knoch, Stefan Müller, and Michele Solimena. "Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in β-cells." Journal of Cell Biology 167, no. 6 (December 13, 2004): 1063–74. http://dx.doi.org/10.1083/jcb.200408172.

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Islet cell autoantigen 512 (ICA512)/IA-2 is a receptor tyrosine phosphatase-like protein associated with the insulin secretory granules (SGs) of pancreatic β-cells. Here, we show that exocytosis of SGs and insertion of ICA512 in the plasma membrane promotes the Ca2+-dependent cleavage of ICA512 cytoplasmic domain by μ-calpain. This cleavage occurs at the plasma membrane and generates an ICA512 cytosolic fragment that is targeted to the nucleus, where it binds the E3-SUMO ligase protein inhibitor of activated signal transducer and activator of transcription-y (PIASy) and up-regulates insulin expression. Accordingly, this novel pathway directly links regulated exocytosis of SGs and control of gene expression in β-cells, whose impaired insulin production and secretion causes diabetes.

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