Dissertations / Theses on the topic 'IBV'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'IBV.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Hackney, Karen. "IBV D-RNAs as delivery vectors for heterologous genes." Thesis, University of Leeds, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250926.
Full textWinter, Christine. "Charakterisierung des IBV-Spike-Proteins Bindungseigenschaften und Lokalisation in eukaryotischen Zellen /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=978261763.
Full textJayaram, Jyothi. "Studies on the nucleocapsid protein of infectious bronchitis virus." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/2243.
Full textQuadros, Valter Leonardo de [Verfasser]. "Das Infektiöse Bronchitis Virus (IBV) : molekularbiologische Untersuchungen zur Diagnostik und zum Vorkommen sowie zur Pathogenität des Genotyps IBV QX in spezifisch pathogenfreien (SPF) Broilern / Valter Leonardo de Quadros." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/102727577X/34.
Full textSantos, Helton Fernandes dos. "Anticorpos contra vírus de aves em galinhas de terreiro e cracídeos. Identificação e susceptibilidade a antimicrobianos da microbiota de cracídeos cativos no RS, Brasil." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/10006.
Full textPoultry production is a very important economic activity in Brazil once the country is among the highest world avian producers. The knowledge of the pathogens epidemiology is essential to the control of infectious diseases and such control is very strict in chickens and turkeys on the avian industry. However, the avian population of the country shows a big diversity of domestic and wild birds and the chicken backyard population is out of this control. To investigate the presence of antibodies against specific viruses in the backyard chicken population, blood was collected of 867 non-vaccinated birds, from 60 farms and 22 counties from the Rio Grande do Sul State, Brazil. Neutralizing antibodies against infectious bronchitis virus (IBV) were detected in 65% (564/867) of the individuals, against avian reovirus (ARV) in 21.6% (187/867) and, against infectious bursal disease virus (IBDV) in 80.2% (695/867). The results presented on the first chapter indicated that the tested viruses are circulating among this population. Among the wild species there is a group of Galliformes, classified at the Cracidae family and commonly known as guans, chachalacas and curassows which deserved a special attention in the present study. To determine the microbiota, the bacterial resistance and the presence of antibodies against specific viruses in these birds, fifty one serum and cloacal swab samples were collected from 10 different cracid species captive in the Rio Grande do Sul State during 2007. Serum samples were submitted to serum-neutralization test and specific antibodies were detected against IBV in 5.9% (3/51) of the cracids, against ARV in 15.7% (8/51) and, against IBDV in 35.3% (18/51). All the samples were found to be negative to fowlpox virus by the AGID test. Bacterial isolation and identification were performed from the cloacal swabs. After that, the isolates were tested for antimicrobial susceptibility. Ninety three bacterial isolates were obtained from 10 different genera. Escherichia spp., Staphylococcus spp. and Streptococcus spp. are among the most prevalent genera. Antimicrobial resistance was observed in several isolates, with Serratia marcescens presenting the highest level of resistance to multi drugs followed by Streptococcus spp., Staphylococcus aureus and Escherichia coli, among others. The results from the second chapter of this dissertation allowed us to conclude that bacterial resistance is spread in the captive cracid microbiota and, most importantly, these species are susceptible to the infection by IBV, IBDV and ARV.
A avicultura é uma das principais atividades econômicas do Brasil, que ocupa posição de destaque entre os exportadores de frango e subprodutos. O conhecimento da epidemiologia de patógenos que podem gerar prejuízos a essa atividade é essencial para o controle das enfermidades infecciosas. Este controle é realizado em larga escala em galinhas e perus criados no sistema industrial. Entretanto a população avícola do país consiste de uma grande diversidade de aves domésticas e selvagens, sendo o grupo conhecido como galinhas de terreiro formado por indivíduos desta espécie criados fora do sistema industrial. Com o objetivo de investigar a presença de anticorpos contra alguns vírus específicos na população de galinhas de terreiro, foram coletadas amostras de sangue de 867 galinhas não vacinadas, em 60 propriedades de 22 municípios do Estado do Rio Grande do Sul, Brasil, que foram testadas pela técnica de soroneutralização. Anticorpos contra o vírus da bronquite infecciosa das galinhas (IBV) foram detectados em 65% (564/867) destas aves, contra o reovírus aviário (ARV) em 21,6% (187/867) e contra o vírus da doença infecciosa da bolsa (IBDV) em 80,2% (695/867). Os descritos no primeiro capítulo desta dissertação permitiram demostrar a circulação dos vírus testados na população descrita. No segundo capítulo trabalhou-se com aves da ordem Galliformes, pertencentes à família Cracidae e conhecidos popularmente como jacus, jacutingas, araquãs e mutuns, com o intuito de conhecer a microbiota, resistência bacteriana e a presença de anticorpos contra vírus de aves, 51 amostras de soro e swab cloacal de 10 diferentes espécies de cracídeos cativos do Estado do Rio Grande do Sul foram coletadas durante o ano de 2007. As amostras de soro foram utilizadas para a detecção de anticorpos neutralizantes contra o IBV, ARV e IBDV, onde obteve os seguintes resultados: contra o IBV em 5,9% (3/51) das amostras positivas, contra o ARV em 15,7% (8/51) e contra o IBDV em 35,3% (18/51). Através do teste de imunodifusão em gel de ágar (IDGA) determinou-se que todas as amostras de soro eram negativas para o vírus da bouba aviária. Para o isolamento e identificação bacteriana foram realizados dos swabs cloacais e, posteriormente, foi testada a susceptibilidade antimicrobiana. Foram obtidos 93 isolados bacterianos, divididos em 10 diferentes gêneros. Entre os gêneros bacterianos mais prevalentes estavam Escherichia spp., Staphylococcus spp. e Streptococcus spp. Foi observada em grande número de isolados resistência à antimicrobianos, sendo que a bactéria Serratia marcescens apresentou o maior índice de resistência múltipla antimicrobiana. Os altos índices de resistência também foram detectados para Streptococcus spp., Staphylococcus aureus e Escherichia coli. Os resultados apresentados permitem concluir que a resistência bacteriana está disseminada na microbiota de cracídeos cativos e que indivíduos destas espécies são suscetíveis à infecção pelo IBV, IBDV e ARV, assim como as galinhas de terreiro.
Bentley, Kirsten. "IBV : potential as a vaccine vector and identification of a novel subgenomic mRNA." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/54374/.
Full textMartini, Matheus Cavalheiro 1983. "Estudo experimental em camundongos e aves comerciais com isolado de pombo do vírus da bronquite infecciosa (IBV) = Experimental study in mice and poultry with isolated from pigeon infectious bronchitis virus (IBV)." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316633.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-26T04:15:51Z (GMT). No. of bitstreams: 1 Martini_MatheusCavalheiro_D.pdf: 16763908 bytes, checksum: 65c4aed6451181f383a10560fce87e51 (MD5) Previous issue date: 2014
Resumo: O vírus da Bronquite Infecciosa (VBI), pertencente à família Coronaviridae, é um importante patógeno à sanidade e fatores econômicos da produção avícola no Brasil e no mundo. O VBI possui múltiplos sorotipos e o frequente surgimento de novas variantes é um dos principais problemas relacionados a este vírus. Este trabalho tem como objetivo a investigação experimental da patogênese de um isolado de pombo (Columba/Brazil/2007/Unicamp/67T), caracterizado molecularmente pelo gene S1 como VBI sorotipo Massachusetts, e seus efeitos in vivo, em galinhas e camundongos. O presente estudo foi dividido em duas partes, na primeira um grupo de aves "specific pathogen free" (SPF) foi inoculado pela via óculo-nasal com a amostra viral proveniente de pombo. Os animais, de um dia de vida, foram sacrificados nos dias 2, 4, 5, 7, 9, 11, 14, 21, 28, 35 e 42 dias pós-inoculação (dpi). Foram coletados suabes de traqueia, seio nasal e cloaca, além de órgãos como pulmão, íleo, pró-ventrículo (coletado entre 7 e 21 dpi), rim, tonsilas cecais (coletada a partir de 4dpi) e testículos (coletado a partir de 5 dpi). Sinais clínicos respiratórios como espirros, estertores, corrimento nasal, além de letargia, diarreia e perda de coordenação foram observados principalmente no 5dpi. A inibição da atividade ciliar ocorreu concomitantemente ao pico de sinais clínicos das aves. Foi analisado tropismo tecidual, através da quantidade de RNA viral detectado, pelo trato digestório. Os maiores títulos de RNA viral foram detectados na tonsila cecal, seguida pelo íleo (ambos no 5dpi) e cloaca (no 2dpi). Além disso, houve detecção de RNA viral no rim e trato respiratório, com maior título de RNA viral na traqueia. Os órgãos que apresentaram maiores danos teciduais através do exame histopatológico foram o rim, íleo e traqueia (todos no 5dpi). Por fim, as aves inoculadas com a amostra do VBI oriundo de pombo produziram anticorpos entre os dias 14 e 21dpi, detectados no soro destes animais através do ELISA. Na segunda parte do trabalho, a capacidade de replicação de diferentes variantes do VBI em camundongos foi avaliada. Para tanto, camundongos das linhagens Balb/C e A/J foram inoculados pela via nasal com duas amostras do sorotipo Massachussets (Mass) e com a variante brasileira (BR-I), e sacrificados no 3, 10 e 14 dpi. Não foram observados sinais clínicos nem lesões macroscópicas graves. O RNA viral foi detectado em todos os órgãos coletados, sendo os principais órgãos de replicação o seio nasal e pulmão (no 3dpi) para os camundongos da linhagem A/J e pulmão e duodeno (ambos no 3dpi) na linhagem de camundongos Balb/C, nos quais os títulos virais detectados foram mais altos. Pneumonia intersticial, edema e infiltrado mononuclear foram as principais alterações histopatológicas observadas no 3dpi em camundongos inoculados com as diferentes variantes. A presença da nucleoproteína viral, pela imunohistoquímica, foi detectada no duodeno, traqueia e pulmão de camundongos no 3dpi nas duas linhagens de camundongos. Os anticorpos contra o coronavírus aviário foram detectados somente no 3dpi. Assim, os resultados do presente estudo demonstraram que a variante Massachussets, com origem de pombo, causa a doença clínica em aves comerciais não vacinadas e pode replicar em modelo mamífero por um curto período de tempo, ressaltando a importância da vacinação e o papel potencial dos roedores como possível reservatório e carreador do vírus
Abstract: Infectious bronchitis virus (IBV) belonging to the family Coronaviridae is an important pathogen to sanity and economics of poultry production in Brazil and worldwide. The VBI has multiple serotypes and the frequent emergence of new variants is one of the main problems related to this virus. This work aims to experimentally investigate the pathogenesis of pigeon sample (Columba/Brazil/2007/Unicamp/67T), molecularly characterized by S1 gene as IBV Massachusetts serotype, and its effects in vivo in chickens and mice. This study was divided into two parts. In the first part, a group of birds "specific pathogen free" (SPF) was inoculated by oculo-nasal route with the viral sample from pigeon. The animals with one-day-old, were sacrificed on 2, 4, 5, 7, 9, 11, 14, 21, 28, 35 and 42 days post-inoculation (dpi). Tracheal swabs, nasal sinus and cloaca were collected, and organs such as lung, ileum, pro-ventricular (collected between 7 and 21dpi), kidney, caecal tonsils (collected from 4dpi) and testes (collected from 5 dpi). Clinical signs such as sneezing, rales, nasal discharge, lethargy, diarrhea, and loss of coordination were observed mainly in the 5dpi. Inhibition of ciliary activity occurred concomitantly with the peak of clinical signs of birds. Tissue tropism was analyzed by the amount of viral RNA detected by the gastrointestinal tract. The higher titers of viral RNA were detected in the cecal tonsil, followed by the ileum (both in 5dpi) and cloaca (in 2dpi). In addition, viral RNA was detected in the kidney and respiratory tract, with highest titer of viral RNA in the trachea. The organs that showed severe tissue damage by histopathology were the kidney, ileum and trachea (all in 5dpi). Finally, the birds inoculated with the sample originated from IBV Pigeon produced antibodies between 14 and 21dpi, detected in the serum of these animals by ELISA. In the second part, the replication capacity of different variants of IBV in mice was evaluated. For this, mice of strains BALB/C and A/J were inoculated intranasally with two strains of Massachusetts (Mass) serotype and the Brazilian variant (BR-I), and sacrificed at 3, 10 and 14 dpi. No clinical signs or severe macroscopic lesions were observed. The viral RNA was detected in all organs collected, higher tittles were detected on sinus and lung (in 3dpi) for mice of strain A/J and on lung and duodenum (both in 3dpi) in the line of Balb/C; in this line the viral titles were higher than the strain A/J. Interstitial pneumonia, edema and mononuclear cell infiltration were the main histopathological changes observed in 3dpi in inoculated mice with different variants. The presence of viral nucleoprotein, immunohistochemistry was detected in the duodenum, trachea and lungs of mice in 3dpi in both mice strains. Antibodies against avian coronaviruses have been detected only in 3dpi. Thus, the results of this study demonstrate that the Massachusetts variant, originating from pigeon, cause clinical disease in commercial poultry unvaccinated and can replicate in mammalian model for a short period of time, emphasizing the importance of vaccination and the potential role of rodents as possible reservoir and the carrier virus
Doutorado
Microbiologia
Doutora em Genética e Biologia Molecular
Dashan, Li. "Factors affecting the membrane fusion-inducing capacity of the spike protein of avian infectious bronchitis coronavirus (IBV)." Thesis, Royal Veterinary College (University of London), 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522192.
Full textYoun, Soonjeon. "In vitro assembly of an infectious cDNA clone of infectious bronchitis virus and its application as a gene transfer vector." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/1311.
Full textSandri, Thaisa Lucas. "Vírus da bronquite infecciosa das galinhas (IBV): distribuição, diversidade molecular e genealogia a partir de amostras de múltiplos órgãos de diversos tipos de criação do plantel avícola brasileiro." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-21122010-105658/.
Full textInfectious bronchitis (IB) is a highly contagious disease of poultry caused by multiple geno/serotypes of avian infectious bronchitis virus (IBV), a group 3 coronavirus. Though classically associated to the respiratory tract, IBV strains also have been described which harbor tropism for the kidneys and the reproductive and enteric tracts, and might be detected in multiple tissues and can also affect birds of all ages. This survey aimed to assess the frequency of in multiple organs and enteric content samples from grandparents, breeders, layers and broilers, to genotype the IBV strains detected and to study the molecular diversity amongst Brazilian IBV strains. A total of 844 pools of multiple organs and enteric contents from 200 flocks of grandparents, breeders, layers and broilers from the Southern, Southeastern, Central-Western and Northeastern Brazilian regions collected between 2007 and 2009 was screened for the presence of IBV with an RT-PCR target to the 3 untranslated region (UTR). The sampled birds presented symptoms compatible with IB. All IBV strains detected were then typed using an RT-PCR target to the spike gene of the virus. Nineteen strains type as variants were submitted to partial sequencing of the S1 coding region and genealogic analysis. Regarding the organs and enteric content pools, 45.50% were positive for the presence of IBV, from which 84.63% were variant and 9.89% Massachusetts. Taking into account the flocks, 73.50% were positive for IBV, being 77.55% variants and 6.12% Massachusetts. Genealogic analysis revealed four viral lineages, all grouped in an exclusive Brazilian genotype cluster. This results shown that IBV is widespread in all Brazilian poultry regions, with a massive predominance of non-Massachusetts genotypes and a high molecular diversity, which must be taken into account in order to develop preventive measures against IB.
GUIMARÃES, Bruno Maia. "Exigências da tarefa e o perfil dos trabalhadores com deficiência: um estudo de caso na construção civil usando o software ErgoDis/IBV." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/3337.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
Apesar dos esforços que estão sendo feitos para a inclusão laboral da pessoa com deficiência (PD), observa-se que as deficiências, muitas vezes, podem prejudicar a pessoa na procura de trabalho. O Brasil apresenta cerca de 14,5% da população, ou seja, 24,5 milhões de PDs (IBGE, 2002), porém, de acordo com a RAIS de 2009 somente 288,6 mil estavam em empregos formais no ano de 2009 (BRASIL, 2010). Dessa forma, a ergonomia torna-se imprescindível, uma vez que, através do conhecimento das exigências físicas, cognitivas e organizacionais dos postos de trabalho e a determinação das capacidades funcionais do trabalhador com deficiência, podem ser realizadas adequadamente as adaptações dos postos de trabalho. O objetivo deste estudo foi determinar as exigências físicas da tarefa, indicar o perfil dos trabalhadores com deficiência e definir as adequações necessárias à eficiência do sistema Humano-Tarefa-Máquina, com foco numa obra de construção civil de adutora de abastecimento de água. Foi realizado estudo de campo, onde através do software ErgoDis/IBV foram avaliados três casos reais, postos de trabalho onde há PDs (dois serventes e um armador), para verificar a adequação e/ou a necessidade de alguma adaptação. Além dos casos reais, foram avaliadas as funções de encarregado de turma, pedreiro, carpinteiro e pintor letrista com a finalidade de determinar o perfil dos trabalhadores com deficiência que poderiam exercer essas funções. Para isso foram simulados indivíduos com deficiências no software Ergodis/IBV nas funções avaliadas para determinar se poderiam realizá-las e/ou quais as adaptações necessárias. A partir da análise dos dados foi observado que trabalhadores com deficiência auditiva poderiam exercer as atividades em qualquer uma das funções avaliadas sem nenhuma mudança no ambiente de trabalho e para indivíduos com amputação de perna ou pé, será necessário utilizar próteses adequadas para realizar as atividades nessas funções. Portanto, defende-se que o tema tem um caráter interdisciplinar, devendo ser abordado de forma sistêmica. É fundamental entender as interações entre as pessoas e os elementos dos sistemas de trabalho, a partir dos fundamentos, métodos e técnicas da Ergonomia, de modo a possibilitar a adequação do trabalho às capacidades da PD. Também são importantes os conhecimentos de biomecânica, fisiologia, patologia e dos métodos e técnicas da Fisioterapia, para gerar requisitos e propostas de soluções de Design objetivando facilitar o processo de inclusão laboral das pessoas com deficiência
Santos, Sueli da Silva. "Caracterização e comparação molecular de estirpes de referência e de campo do vírus da bronquite infecciosa das galinhas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-23072012-165711/.
Full textInfectious bronchitis is a viral disease, acute and highly contagious that affects birds of the Gallus gallus species, of all ages, causing huge economic losses due to mortality, drop in production and quality eggs. Differences between serotypes of IBV are due to variations in the amino acids sequence in S1 hypervariable region subunit of spike protein (S). This study aimed to partially sequence the S1 gene to determine the phylogenetic relationship between field and vaccine viral types, and to investigate circulating genotypes in Brazil. One hundred and sixty pool samples were collected from symptomatic flocks during 2009/2010. Each pool contained tissues from 3 to 5 birds and was composed by different organs (tracheas, lungs, kidneys, enteric contents, tract reproductive and tracheal swabs). Samples were screened for the presence of IBV using a nested RT-PCR targeted to the 3UTR. Positive samples (n=56) were submitted to a nested RT-PCR target to S gene resulting in 10 amplicons of 390pb that were then submitted to DNA sequencing and analysis. Brazilian IBV genotypes segregated in two phylogenetic groups: Massachusetts (Mass) and Brazilian types. Six samples clustered in the Mass group, with live attenuated vaccines used in Brazil. Four samples grouped with field Brazilian strains previously described (GeneBank accession: FJ791257 to FJ791273). In Mass cluster aminoacids identity range from 98% to 100%, suggesting vaccine virus detection, in this last case. Moreover, the verified identity between samples from this study and Mass group ranged 79% to 81%. Therefore the present study reinforces the emergence and circulation of news lineages of IBV in commercial Brazilian flocks, as well as the importance of consistent research and monitoring to better understand this phenomen and its consequences, aiming to improved control measures against the virus.
Valastro, Viviana. "Infectious bronchitis virus: phylogeny and evolution." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3421791.
Full textIl virus della bronchite infettiva aviare è l’agente patogeno di una malattia altamente contagiosa responsabile di ingenti perdite economiche nel settore avicolo. Il virus è caratterizzato da una grande variabilità genetica e antigenica che ha favorito la comparsa e la diffusione di molteplici e differenti tipi virali. Analisi filogenetiche e calcolo delle distanze nucleotidiche esistenti tra i ceppi sono state utilizzate per classificare la grande varietà di virus appartenenti a questa famiglia di patogeni. Nonostante ciò, non si è ancora raggiunto un accordo sul metodo con il quale i ceppi dovrebbero essere confrontati. Questo ha generato notevole confusione poiché ha favorito lo sviluppo di numerosi sistemi di classificazione, molto spesso contrastanti l’uno con l’altro, e l’utilizzo di nomenclature eterogenee che in molti casi non riflettevano la filogenesi. Lo scopo di questo lavoro è proporre un sistema di classificazione che sia semplice e ripetibile e basato esclusivamente sulle relazioni filogenetiche esistenti tra i ceppi di bronchite aviaria. Il lavoro si propone inoltre di assegnare una nomenclatura univoca e razionale dei gruppi genici identificati. Mediate l’analisi di tutte le sequenze nucleotidiche della proteina S1 disponibili in banca dati sono stati identificati 32 diversi lineaggi, compresi in 6 genotipi, e un numero di ceppi originati da eventi di ricombinazione tra lineaggi. Poiché la variabilità esistente tra i diversi ceppi di IBV è abbastanza elevata, qui si propone di usare le relazioni filogenetiche piuttosto che il calcolo delle distanze geniche come criterio più adatto per tracciare la storia evolutiva di IBV. L’adozione di una nomenclatura accettata a livello internazionale è di fondamentale importanza per gli studi futuri sull’epidemiologia ed evoluzione del virus della bronchite infettiva aviaria. Inoltre, così com’è stata sviluppata, la classificazione qui proposta può essere revisionata e aggiornata nel momento in cui saranno disponibili nuove sequenze virali della proteina S1.
Noizet, Mildred. "Etude d'une protéine recombinante impliquée dans la formation de structures menbranaires : expression de la protéine de fusion IBV M-GUS dans des cellules de tabac." Compiègne, 2001. http://www.theses.fr/2001COMP1348.
Full textStephan, Thomas Min [Verfasser], Silke [Akademischer Betreuer] Rautenschlein, Georg [Akademischer Betreuer] Herrler, and Egbert [Akademischer Betreuer] Mundt. "Molecular characterization of the spike protein of an avian infectious bronchitis virus (IBV) with cell culture tropism and identification of the underlying determinants / Thomas Min Stephan ; Silke Rautenschlein, Georg Herrler, Egbert Mundt." Hannover : Stiftung Tierärztliche Hochschule Hannover, 2019. http://d-nb.info/1202774873/34.
Full textFranzo, Giovanni. "Further insight into the molecular epidemiology and evolutionary dynamics of rapidly evolving RNA and ssDNA viruses." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424633.
Full textI virus a RNA e a ssDNA rappresentano un affascinante campo di ricerca caratterizzato da una stretta interconnessione fra lo studio di aspetti più “speculativi”, inerenti all’evoluzione virale, e le implicazioni che questi comportano nella pratica veterinaria. La presente tesi è stata concepita come una raccolta di articoli che hanno esplorato diversi aspetti e livelli dell’evoluzione virale senza per questo trascurarne le ripercussioni pratiche. Diverse malattie infettive ed agenti eziologici sono stati selezionati onde investigare i diversi aspetti e implicazioni della rapida evoluzione di questi virus. In considerazione della natura eterogena dei manoscritti prodotti, questi sono stati organizzati secondo una “scala crescente”, dal livello più basso dell’evoluzione virale, procedendo verso scale via via maggiori. L’elaborato “Viral subpopulations in aMPV vaccines are unlikely to be responsible for reversion to virulence” affronta un analisi ad alta risoluzione della presenza di sottopopolazioni virali nei vaccini vivi attenuati basati sul sottotipo B del metapneumovirus aviare e del loro potenziale ruolo nel determinare fenomeni di reversione a virulenza. La somministrazione su vasta scala di vaccini vivi attenuati, nonostante gli ovvi vantaggi in termini di riduzione della prevalenza virale, dei segni clinici e delle perdite economiche, è associata a costi che non sono limitati a quelli di tipo meramente pecuniario. Sulla base di un ampia raccolta di campioni italiani, l’articolo “Continued use of IBV 793B vaccine needs reassessment after its withdrawal led to the genotype’s disappearance” descrive l’impatto di questi vaccini, in assenza di marker vaccinali noti, nel complicare il processo diagnostico e, conseguentemente, l’interpretazione dello scenario epidemiologico. Ovviamente, una conoscenza aggiornata degli stipiti virali circolanti in una particolare area è di fondamentale importanza per l’implementazione di adeguate misure di controllo. Con quest’obiettivo in mente, uno studio di campo , pubblicato in “Diffusione dell’infezione da metapneumovirus aviare in allevamenti di tacchini e broiler nel Nord Italia”, è stato condotto su centinaia di allevamenti al fine di stimare e caratterizzare i ceppi di AMPV circolanti nel nostro territorio. In aggiunta, al fine di favorire studi sempre più frequenti e estesi, è stato sviluppato un test diagnostico in grado di rilevare, quantificare e tipizzare i sottotipi di AMPV attualmente circolanti in Italia. In considerazione del fatto che le spese relative a questi test rappresentano spesso uno dei maggiori limiti all’attività diagnostica e di ricerca, si è cercato di ridurre i costi rispetto ad altre metodiche comunemente utilizzate, garantendo nel contempo le medesime o migliori performance diagnostiche(“A Sensitive, Reproducible, and Economic Real-Time Reverse Transcription PCR Detecting Avian Metapneumovirus Subtypes A and B”). Sfortunatamente la diagnosi dei virus a RNA, essendo caratterizzati da una rapida evoluzione, rappresenta di per se stessa un ardua sfida e richiede una continua dedizione alla rivalutazione e aggiornamento delle metodiche diagnostiche esistenti. Gli articoli Observation of high recombination occurrence of Porcine reproductive and respiratory syndrome virus in field condition” e “Phylodynamic analysis of Porcine reproductive and respiratory syndrome virus (PRRSV) in Italy: action of selective pressures and interactions between different clades.” sono incentrati sullo studio dell’epidemiologia molecolare del Porcine reproductive and respiratory syndrome virus (PRRSV) in Italia. In particolare sono state studiate le forze evolutive che ne modellano e condizionano l’evoluzione (i.e., alto tasso di sostituzione nucleotidica, interazione fra differenti clade e azione di diverse pressioni selettive). L’elevata eterogeneità genetica di PRRSV nel nostro territorio è stata poi analizzata alla luce delle sue ripercussioni nello sviluppo e validazione di metodiche diagnostiche basate sull’uso della RT-PCR e qRT-PCR (“Validation and comparison of different end point and real time RT-PCR assays for detection and genotyping of porcine reproductive and respiratory syndrome virus”) e ne è stato valutato l’impatto sull’accuratezza diagnostica (“The impact of porcine reproductive and respiratory syndrome virus genetic heterogeneity on molecular assay performances”). Similmente, “International trades, local spread and viral evolution: the case of Porcine circovirus type 2 (PCV2) strains heterogeneity in Italy”, indaga la variabilità genetica di PCV2 all’interno dei confine nazionali comparandola altresì con le informazioni di epidemiologia molecolare disponibili per altri Stati. Il presente studio ha permesso di fornire significative evidenze sul ruolo sia dei commerci internazionali che dell’evoluzione “in loco” nel determinare l’eterogeneità di PCV2 riscontrata in Italia. Il progressivo aumento delle sequenza di PCV2 depositate in database pubblici ne ha dimostrato la grande variabilità su scala mondiale e ha evidenziato i limiti dei criteri di classificazione attualmente in uso. Tuttavia, una conoscenza quantomeno superficiale dell’epidemiologia molecolare di PCV2 è di basilare importanza per la pianificazione e la valutazione delle strategie di controllo. “Revisiting the Taxonomical classification of PCV2: still a real challenge” propone dei nuovi criteri per la classificazione di questo virus in diversi genotipi. Il nostro intento è stato quello di fornire uno schema che, pur tenendo conto dei limiti imposti dalle caratteristiche biologiche del virus, permettesse una rapida, pratica e facile genotipizzazione dei ceppi di PCV2 e che potesse quindi rispondere alle esigenze imposte dalla routinaria l’attività diagnostica. Infine, “Genetic characterisation of porcine circovirus type 2 (PCV2) strains from feral pigs in the Brazilian Pantanal: an opportunity to reconstruct the history of PCV2 evolution”, si confronta con il campo, più specualtivo, dell’origine di PCV2. La scoperta di un ceppo appartenente al genotipo PCV2c, sino ad oggi ritenuto estinto, in una popolazione di suini selvatici caratterizzata da una peculiare storia e da complesse, a ancora solo parzialmente conosciute, relazioni con altre specie suscettibili a questo patogeno, apre nuovi ed eccitanti scenari concernenti la storia e l’origine di PCV2
Enany, Ahmed. "Achieving Security in Messaging and Personal Content in Symbian Phones." Thesis, Blekinge Tekniska Högskola, Avdelningen för för interaktion och systemdesign, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-5635.
Full textPhone: +46735731360
Lopez, Juan Carlos. "The effect of environmental stressors on the immune response to avian infectious bronchitis virus." Lincoln University, 2006. http://hdl.handle.net/10182/643.
Full textHasanali, Parveen. "'Ibn Ṭufayl's "Hayy ibn Yaqẓan" : an analytic study." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63793.
Full textBelo, Catarina Carriço Marques de Moura. "Chance and determinism in Ibn Sīnā and Ibn Rushd." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:5dce93b3-846f-4110-962b-2f705f57b4e8.
Full textMarkovsky, Oliver. "Integrierte Schlaganfallversorgung (ISV)." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-83654.
Full textHuber, Thorsten. "Integrierte Schlaganfallversorgung (ISV)." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-89136.
Full textRasmusson, Emil, and Fredrik Silvennoinen. "Rekonditionering av IBC." Thesis, KTH, Tillämpad maskinteknik (KTH Södertälje), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-147806.
Full textKemp, E., M. Floyd, E. McCord-Duncan, Beth Ann Bailey, Ivy A. Click, and J. Gorniewicz. "IPV Detection Strategies." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/6406.
Full textFloyd, M., E. Kemp, E. McCord-Duncan, Beth Ann Bailey, Ivy A. Click, and J. Gorniewicz. "IPV Detection Strategies." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/6416.
Full textRolland-Fourcade, Claire. "Les protéases et leurs inhibiteurs sécrétés par la cellule épithéliale : acteurs de l'inflammation et de la douleur." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30353/document.
Full textProteases are involved in some biologic processes and their origins are variable (immune cells, epithelial cells...). Their activity is regulated by antiproteases. This study investigates the balance between proteases and their inhibitors in pathologies which modify epithelium integrity. Consequences of an unbalance in proteolytic activity was studied in two chronic pathologies with different components: Inflammatory Bowel Disease (IBD) (cycles of inflammatory boost) and Irritable Bowel Syndrome (IBS) (cycles of pain symptoms). Colonic mucosa from IBS patients releases trypsin activity. The origin and the functions of this activity are not well defined. This study investigated the source of this trypsin activity in the côlon of IBS patients, its nature and its role in neuronal activation. Trypsin activity from IBS patients is increased mostly in epithelial cells. Stimulation of epithelial cell monolayers with LPS or epinephrine induces an increase of trypsin-3 quantity and its secretion specifically in the basal side of epithelial cells. This is in correlation with the increase of trypsin activity. Trypsin-3 hyperactivity at the basal side provokes a loss of epithelium barrier function, which is also found in colons of IBS patients. Then, we have highlighted that trypsin-3 is able to activate human myenteric neurons and murine sensitive neurons. In vivo, its intra-rectal administration to mice induces a visceral hypersensitivity dependent of PAR2 (Protease Activated Receptors 2). Thus, intestinal epithelial cells from IBS patients produce and release trypsin-3 specifically on their basal side. This trypsin activity activates sensitive neurons which participate to visceral hypersensitivity, a major symptom of IBS patients. Inflammatory pathologies could be a source of proteolytic malfunction. IBD patients have a dysregulation of elastolytic balance in the colon. Our team has shown that ELAFIN (an elastase inhibitor) delivered by the bacteria genetically modified L.lactis near the inflamed mucosa, protects mice from intestinal inflammation. However, the protective mechanisms induced by ELAFIN need to be investigate. ELAFIN is an elastase inhibitor but have also antimicrobial properties. With the aim to highlight what function of ELAFIN owns anti-inflammatory properties, mutants of ELAFIN have been generated and were insered into L.lactis: a first mutant lacked its antiprotease function, a second lacked antimicrobial properties and a last mutant lacked both properties. In intestinal epithelial monolayers, ELAFIN delivered by L.lactis protects against inflammation: a restauration of epithelial barrier function and a decrease of pro-inflammatory cytokines (CXCL8 and IP10) are observed. Mutation of antimicrobial domain doesn't affected these properties. Nevertheless, the absence of inhibitory loop annihilates anti-inflammatory functions of ELAFIN. This work highlights the importance of proteolytic balance inside the epithelial cell in intestinal pathologies. The balance between proteases and antiproteases plays an important role in epithelial homeostasis
Keilwerth, Melanie. "Inclusion body disease (IBD)." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-119147.
Full textEllström, Jonathan. "Exploring IBM Integration Designer." Thesis, Mittuniversitetet, Avdelningen för informationssystem och -teknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-31545.
Full textHusin, Muhammad Said. "Ibn Jamāʻah's educational thought." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23217.
Full textYate, Assadullah ad-Dhaakir. "Ibn Rushd as jurist." Thesis, University of Cambridge, 1992. https://www.repository.cam.ac.uk/handle/1810/283678.
Full textMorales, Luna Félix. "Ubi societas, ibi futbol." Foro Jurídico, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/119998.
Full textGünter, Roland. "10 Jahre IBA – und was nun? : Perspektiven für die Region nach der IBA." Universität Potsdam, 2003. http://opus.kobv.de/ubp/volltexte/2009/3054/.
Full textKaya, Emrah. "Epistemology and theology of Ibn al-ʿArabī and Ibn Taymiyya : a comparative study." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33659/.
Full textRudavsky-Brody, Miriam. "Solomon ibn Gabirol and Samuel ibn Naghrela: An Examination of Life and Death." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1374014712.
Full textPitman, Gregory James. "Digital signal processing software packages for IBM-PC and IBM-PC with DSP-16." Thesis, Monterey, California. Naval Postgraduate School, 1989. http://hdl.handle.net/10945/26996.
Full textAdang, Camilla Patricia Wilhelmina Maria. "Muslim writers on Judaism and the Hebrew Bible from Ibn Rabban to Ibn Ḥazm /." Nijmegen, 1993. http://catalogue.bnf.fr/ark:/12148/cb356041308.
Full textMyers, Rachel Kathryn. "Childhood Witnessing of Intimate Partner Violence (IPV) And Early Adulthood IPV Among Urban Women." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/377989.
Full textPh.D.
Annually, more than 15 million U.S. children witness intimate partner violence (IPV) in their homes between caregivers. Witnessing IPV during childhood has been associated with increased risk of adulthood IPV victimization, although this relationship has most commonly been examined among older populations of white adults (McKinney, Caetano, Ramisetty-Mikler, & Nelson, 2009; Straus, 1989; Whitfield, Anda, Dube, & Felitti, 2003), not minority women who experience a disproportionately high burden of IPV victimization (Breiding, Chen, & Black, 2014). It also is unclear whether there are specific characteristics of childhood witnessing of IPV that may aid in understanding the increased probability of IPV victimization observed among young, minority women. This study examined associations between four characteristics of childhood witnessing of IPV (direction of violence witnessed, academic disruption, fearfulness, and frequency) and adulthood physical and sexual IPV victimization. Further, psychosocial moderators of these associations were examined. Existing data collected from 315 women residing in North Philadelphia were analyzed. Overall, 28% of women witnessed IPV during childhood and nearly one in four women reported IPV victimization. Among these women there was diversity with regards to the characteristics of witnessing reported. Unadjusted associations observed that women who witnessed bidirectional IPV, experienced academic disruption, or reported fearful witnessing were significantly more likely to experience adulthood IPV victimization than women who did not witness IPV during childhood. After adjusting for covariates, these witnessing characteristics were no longer significantly associated with adulthood IPV victimization; however, the risk of adulthood IPV victimization was consistently related to current depressive symptoms and substance use. Modest support for effect modification by low self-esteem was observed. A significant difference in the predicted probability of adulthood IPV victimization was observed among women reporting bidirectional childhood witnessing of IPV and high self-esteem in adulthood compared to women reporting bidirectional witnessing and low self-esteem (difference=0.51, 95% CI: 0.06, 0.95, p=0.027). Childhood abuse was associated with greater probability of adulthood IPV victimization regardless of the frequency of childhood witnessing of IPV (aOR=5.8, 95% CI: 2.2, 13.6). Given the high prevalence of childhood witnessing of IPV observed in this study, these findings highlight the importance of screening for childhood IPV witnessing. In addition, these results suggest particular groups of urban women who may be at highest risk for adulthood IPV victimization, including those experiencing depressive symptoms, substance use, and a history of childhood abuse. Identifying adolescents and young adults with these characteristics and providing early prevention services may reduce the probability of future IPV victimization among young, sexually active urban women. Additionally, examining the role of low self-esteem during child- and adulthood may inform efforts to prevent IPV victimization. These findings highlight the need for prospective, longitudinal studies of urban children and adolescents to examine the complex causal pathways between childhood witnessing of IPV, psychosocial characteristics, and adulthood IPV victimization.
Temple University--Theses
Berg, Wolfgang. "Kanalentwicklungsprozess bei der IAV Chemnitz." Universitätsbibliothek Chemnitz, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-201000817.
Full textMartin, David. "Delivery of ITV Chemistry Classes." TopSCHOLAR®, 2007. http://digitalcommons.wku.edu/theses/407.
Full textLamotte, Virginie. "Ibn Taymiyya's theory of knowledge." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22601.
Full textDurbin, Daniel A. "IBM PC Voice Mail Cards." International Foundation for Telemetering, 1989. http://hdl.handle.net/10150/614731.
Full textThe Voice Main Card (VMC) functions as an enhanced telephone answering machine and is designed as a plug-in card for the IBM PC and compatibles. In addition to standard answering machine functions, the VMC features programmable outgoing message selection, message routing, response to caller's touch tone signals, and remote programming ability. The VMC will answer incoming telephone calls, deliver outgoing messages which are Programmably selectable from as many as 16 digitized audio messages stored on the PC's hard disk, record incoming messages to the hard disk or optionally to an external tape recorder, route messages to a specified receiver, respond to a caller's touch tone signals, and enter a remote programming mode as a result of a special code sent by the caller. Audio messages are processed digitally via A/D and D/A converters which receive and send 8-bit data to and from the IBM PC through a selectable port address. The A/D conversion is implemented with the ADC0802 which is operated at a clock rate of 512 kHz. The D/A conversion is implemented with the DAC0830. Interface with the telephone line is accomplished with the speech circuit TP5700 coupled through opto-couplers. Messages are recorded using an external 600-ohm dynamic microphone and played back through an external 8-ohm speaker. A full-featured, pull-down menu program is provided with the VMC and implements all programmable functions. Data In/Out (I/O) with the card is interrupt-driven to allow apparent simultaneous disk I/O.
Abiib, Amina. "Probiotika som behandling vid IBS." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-58242.
Full textBackground: IBS (Irritable Bowel Syndrome) is a functional gastrointestinal disorder, with an unclear etiology and pathophysiology. IBS is a common disorder in the Western population and is characterized by recurrent abdominal pain/ discomfort, bloating, flatulence, diarrhea and/ or constipation. There is currently no cure for IBS, but the interest in probiotics as an option of treatment has recently increased. Probiotics have been defined as live microorganisms that, when administered in adequate amounts, provide a health benefit on the host, and are believed to have a symptomatic effect in IBS. Probiotics have therefore been of interest for the treatment in IBS. Purpose: The purpose of this study is to examine whether probiotics have a therapeutic effect and if it could be used as a treatment for IBS. Method: Five randomized, double-blind, placebo-controlled studies were reviewed that examined the therapeutic effect of different probiotics in the IBS-patients. Articles were obtained through searches in the medical database PubMed, during the month of February 2016. Results: Four of the five studies showed a significant improvement of symptoms especially in abdominal pain/ discomfort. The best results were seen in a study that investigated the probiotic Lactobacillus plantarum 299v. Three of the five studies showed a significant improvement in quality of life (QOL) of the subjects in the study. One of the five studies which examined the effect of Escherichia coli Nissle 1917, there was no significant difference between E.coli (probiotics) and placebo. Conclusion: There is reasonable evidence that treatment with certain probiotics might provide improvement in symptoms of abdominal pain/ discomfort, and increase patients quality of life based on the five studies. Further studies are required to determine the most effective probiotic, dose and duration of IBS-treatment.
Jelen, Jakub. "Analýza výkonnosti procesorů IBM POWER8." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2016. http://www.nusl.cz/ntk/nusl-255328.
Full textŠoltýs, Matej. "Big Data v technológiách IBM." Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-193914.
Full textPunsomreung, Treechada. "Intimate Partner Violence ( IPV ), Factors Influencing IPV, and Adverse Maternal Health among Pregnant Thai Women." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337352289.
Full textBoutz, Jennifer Hill. "Ḥassān ibn Thābit, a true mukhaḍram a study of the Ghassānid odes of Ḥassān ibn Thābit /." Connect to Electronic Thesis (ProQuest), 2009. http://0-pqdtopen.proquest.com.library.lausys.georgetown.edu/#abstract?dispub=3371616.
Full textRechenberg, Ingo. "Evolutionsstrategie '94 /." Stuttgart : Frommann-Holzboog, 1994. http://www3.ub.tu-berlin.de/ihv/000219248.pdf.
Full textSteinbach, Jörg. "Chemische Sicherheitstechnik /." Weinheim ; New York ; Basel ; Cambridge ; Tokyo : VCH, 1995. http://www3.ub.tu-berlin.de/ihv/000261483.pdf.
Full textFlecke, Ursula. "Zur Genese der Nachmoderne im Städtebau : Entwürfe 1960 - 1975 in Westdeutschland /." Berlin : Techn. Univ., Univ.-Bibliothek, Abt. Publ, 1999. http://www3.ub.tu-berlin.de/ihv/000568903.pdf.
Full textDehrendorf, Martin Heiss Michael. "Geo-Informationssysteme in der kommunalen Planungspraxis /." Norden ; Halmstad : Points-Verl, 2004. http://www3.ub.tu-berlin.de/ihv/000945955.pdf.
Full text