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Barreto, Honoria Maia, Luh Komang Candra Dewi, and Lucio Ximenes. "The Effect of Customer Relationship Marketing (CRM) and Service Quality on Customer Satisfaction Mediated by the Brand image at Bank of BNCTL, Dili Branch, Timor-Leste." Journal of Digitainability, Realism & Mastery (DREAM) 1, no. 01 (July 8, 2022): 41–48. http://dx.doi.org/10.56982/journalo.v1i01.12.
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This study aims to analyze the Effect of Customer Relationship Marketing (CRM) and Service Quality on Customer Satisfaction Mediated by the Brand image at Bank BNCTL, Dili-Timor Leste Branch. The sample in this study uses a purposive sample. The purpose of using this technique is to take a sample of certain people who meet the requirements. Researchers will distribute questionnaires to customers who have the saving at BNCTL bank for at least 1 year. The results of the analysis show that 1) Customer Relationships Marketing has a positive and significant effect on brand image. 2) Service quality has a positive and significant effect on brand image. 3) Brand image has a positive and significant effect on customer satisfaction. 4) Customer Relationships Marketing has a positive and significant effect on customer satisfaction. 5) Service quality has a positive and significant impact on customer satisfaction at the BNCTL Bank Dili Branch, Timor Leste.
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Moenardy, Khalid K., and Lucio Ximenes. "The Influence of Product Quality, Brand Image, and Promotion on Product Purchase Decisions." Journal of Digitainability, Realism & Mastery (DREAM) 2, no. 12 (December 4, 2023): 174–87. http://dx.doi.org/10.56982/dream.v2i12.174.
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The aim of this research is to determine the influence of product quality, brand image and promotion on purchasing decisions for GOTA mineral water in Dili Timor Leste. The research object is consumers of GOTA mineral water in areas of the city of Dili from various backgrounds taken by researchers to study and then draw conclusions. The population in this study were consumers of GOTA mineral water in the city of Dili including students, employees and housewives, totaling 100 people used as samples. The sampling technique used was interviews and questionnaire distribution method Purposive sampling. The data analysis technique used in this research is multiple linear regression analysis. Based on the results of classical assumption tests carried out through normality, multicollinearity and heteroscedasticity, it shows that all the variables used do not conflict with the specified conditions. Meanwhile, according to the results of the model feasibility test, the regression model used in this research is suitable for use. Based on the results of hypothesis testing, it shows that the variables of product quality, brand image and promotion have a positive and significant effect on purchasing decisions.
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Muraviova, Diana, Yuliia Kharchenko, Kateryna Pierzynowska, Stefan Pierzynowski, Jarek Wolinski, Olga Dyomshyna, Volodymyr Zhyliuk, and Galyna Ushakova. "The impact of ademetionine and ipidacrine/phenibut on the NCAM distribution and behavior in the rat model of drug-induced liver injury." European Journal of Clinical and Experimental Medicine 18, no. 3 (2020): 155–64. http://dx.doi.org/10.15584/ejcem.2020.3.1.
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Introduction. Recently, more attention is being paid to the drug-induced liver injury (DILI) as a consequence of the tuberculos is treatment and the need for new medicine is emphasized. The use of isoniazid and rifampicin has a potentiating effect, which increases the risk of substancial liver damage. In turn, systemic accumulation of toxic metabolites leads to negative changes in various organs, including the brain. It causes an imbalance in biochemical and neurophysiological processes in the brain, ultimately giving the onset to the development of hepatic encephalopathy. Aim. The effects of rifampicin and isoniazid on the central nervous system have not been studied before and we aimed to evaluate the impact these two substances have on the neuronal cell adhesion molecules (NCAM) distribution and animal behavior in the rat model of DILI. Material and methods. The 24 male Wistar rats, weighing 180-220 g were used for the experiment and divided to the groups (n=6): 1 – control; 2 – rats with experimental DILI; 3 – rats with DILI plus the intravenous infusion of S-adenosyl-L-methionine at a dose of 35 mg/kg; 4 – rats with DILI plus a fixed combination of ipidacrine hydrochloride at a dose 1 mg/kg body weight and phenibut at a dose 60 mg/kg body weight daily for the last 14 days of the experiment. All experimental procedures were carried out in the accordance with the principles outlined in the current Guide to the Care and Use of Experimental Animals. The locomotor and research activities were studied in the open field test. The activity of aspartate aminotransferase (AST, ЕС 2.6.1.1) and alanine aminotransferase (ALT, ЕС 2.6.1.2) in the serum of rats were tested to confirm the liver damage. The quantitative analyses of soluble and membrane forms of NCAM were performed with ELISA. The ANOVA followed by a Tukey post-hoc test was used to assess statistical differences between groups. Results. Our investigation in the open field test revealed a significant decrease in the locomotor and research activity of rats after 28 days of rifampicin and isoniazid administration. The recovery of investigated parameters was observed in groups of animals treated with ademetionine (AD group) or combination of ipidacrine and phenibut (IP/PB group). We also observed that changes in rats’ behavior were consistent with alterations of the NCAM levels in the thalamus and hippocampus. Thus, the level of membrane NCAM was significantly decreased under DILI in both investigated brain regions (thalamus and hippocampus), while both AD and IP/PB treatments restored membrane NCAM levels towards those observed in the control group at least in the hippocampus. Conclusion. Obtained data suggests that both ademetionine and combinated drug containing ipidacrine and phenibut possesses neuroprotective properties and could prevent the decline in synaptic plasticity under antitubercular therapy.
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Aydin Karimova, Parvin. "Dilin fələsəfəsi." SCIENTIFIC WORK 78, no. 5 (May 17, 2022): 64–68. http://dx.doi.org/10.36719/2663-4619/78/64-68.
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Philosophical examinations about the idea of language have become increasingly convincing over the most recent couple of hundreds of years. The contemplations about language are objects for different regions of logical research just as for hypothetical addressing. Philosophical investigation of language reveals insight into a wide range of fields like instruction, phonetics, humanism, legislative issues, brain science, and so forth. It could be said, where there is human life, there exists a hint of language since language is the most particular limit of man. Reasoning of language gives a profound foundation to both different fields of theory and different logical examinations. This article is both topical and chronicled; my significant point is to empower all individuals intrigued by language and theory to discover associations with their own subjects of study while presenting the field of philosophical examinations about language. Key words: philosophy of language, idea of language, model of communication, rules of language, theory Pərvin Aydın qızı Kərimova Dilin fələsəfəsi Xülasə Dil ideyası ilə bağlı fəlsəfi araşdırmalar son bir neçə yüz il ərzində getdikcə daha inandırıcı olmuşdur. Dillə bağlı mülahizələr məntiqi tədqiqatın müxtəlif bölgələri üçün də obyektdir. Dilin fəlsəfi tədqiqi təlimat, fonetika, humanizm, qanunvericilik məsələləri, beyin elmi və s. kimi geniş sahələrə dair fikirlər ortaya qoyur. Demək olar ki, insan həyatı olan yerdə dilin eyhamı var, çünki dil insanın ən xüsusi sərhəddidir. Dilin əsaslandırılması həm nəzəriyyənin müxtəlif sahələrinə, həm də müxtəlif məntiqi imtahanlara dərin əsas verir. Bu məqalə həm aktual, həm də xronika xarakterlidir. Əhəmiyyətli məqam dil və nəzəriyyə ilə maraqlanan bütün fərdlərə dil haqqında fəlsəfə sahəsini təqdim edərkən öz tədqiqat mövzuları ilə assosiasiyalar kəşf etmək səlahiyyətini verməkdir. Açar sözlər: dil fəlsəfəsi, dil ideyası, ünsiyyət modeli, dil qaydaları, nəzəriyyə
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Yamashiro, Hiroyasu, and Nao Morii. "Abemaciclib-induced lung damage leading to discontinuation in brain metastases from breast cancer: A case report." World Journal of Clinical Cases 11, no. 35 (December 16, 2023): 8425–30. http://dx.doi.org/10.12998/wjcc.v11.i35.8425.
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BACKGROUND This case report addresses the dearth of effective therapeutic interventions for central nervous system metastases in patients with HER2-negative breast cancer. It presents a unique case of a woman with estrogen receptor-positive, HER2-negative breast cancer who developed brain metastasis. The report highlights her initial favorable response to abemaciclib and letrozole therapy prior to the discontinuation due to drug-induced lung damage (DILD). CASE SUMMARY In this comprehensive case summary, we present the clinical course of a woman in her 60s, who 11 years following primary breast cancer surgery, was diagnosed with multiple brain metastases. As a third-line systemic therapy, she underwent treatment with abemaciclib and letrozole. This treatment approach yielded a near-partial response in her metastatic brain lesions. However, abemaciclib administration ceased due to the emergence of DILD, as confirmed by a computed tomography scan. The DILD improved after 1 mo of cessation. Despite ongoing therapeutic efforts, the patient’s condition progressively deteriorated, ultimately resulting in death due to progression of the brain metastases. CONCLUSION This case underscores the challenge of managing adverse events in responsive brain metastasis patients, given the scarcity of therapeutic options.
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Cindy, Cindy, and Daniel Tamburian. "Pengaruh Brand Ambassador Didi Kempot terhadap Citra Perusahaan Shopee." Prologia 6, no. 1 (March 2, 2022): 95. http://dx.doi.org/10.24912/pr.v6i1.10309.
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The era of advanced change is showing the rapid growth of the internet. It also applies to e-commerce development in Indonesia. There are many ways used by e-commerce companies in the hope of surviving the competition of one another, one of the strategies is using the brand ambassaddor to help the companies to build their corporate image. The strategy that Shopee used to appoint the Brand ambassaddor is with the purpose to communicate and represent a certain product as well as to build the company identity. this research aims to determine the impact of Didi Kempot as the brand ambassaddor to the corporate image of Shopee. The theories used in this research are brand ambassaddor, corporate image and public relations. This research used quantitative methods with a survey method. The technique in this study uses non-probability sampling using a purposive sampling approach, the data collection techniques used are by using questionnaire of 100 respondents and literature study. The result of simple linear regression returns a positive constant, which means if there is an increase in brand ambassaddor variable then the corporate image will also be increased. The result of Pearson correlation analysis of the two variables has the moderate degree between brand ambassaddor Didi Kempot to the corporate image of Shopee with 0.581 as the correlation value. The conclusion of this research is that the brand ambassaddor has a significant impact on the corporate image of Shopee.Perubahan zaman yang semakin maju memperlihatkan adanya kemajuan internet yang begitu cepat, sehingga e-commerce di Indonesia pun turut ikut serta dalam perkembangan tersebut.Berbagai cara dilakukan oleh setiap perusahaan e-commerce dengan cepat untuk bisa bertahan dan bersaing, salah satunya yaitu memakai brand ambassaddor untuk membantu perusahaan dalam membentuk citranya. Strategi yang dilakukan oleh Shopee sendiri dalam menggunakan brand ambassaddor memiliki tujuan untuk membentuk sebuah identitas dan mengkomunikasikan atau merepresentasikan suatu produk dari sebuah perusahaan. Tujuan yang ingin dicapai dalam penelitian ini yaitu untuk mengetahui apakah terdapat pengaruh brand ambassaddor Didi Kempot terhadap citra perusahaan Shopee. Dalam penelitian ini menggunakan teori brand ambassaddor, citra perusahaan dan public relations. Penelitian ini memakai metode kuantitatif dengan jenis metode survei. Teknik dalam penelitian ini menggunakan non-probability sampling dengan memakai pendekatan purposive sampling, Teknik pengumpulan data pada penelitian ini menggunakan kuesioner pada 100 responden dan studi kepustakaan. Hasil dari uji regresi linier sederhana bernilai positif dalam konstanta,artinya jika ada peningkatan pada variabel brand ambassaddor maka citra perusahaan juga meningkat. Hasil uji korelasi pearson kedua variabel memiliki tingkat hubungan sedang antara brand ambassaddor Didi Kempot terhadap citra perusahaan Shopee dengan nilai korelasi 0,581. Kesimpulan dari penelitian ini menyatakan bahwa brand ambassaddor memiliki pengaruh yang signifikan terhadap citra perusahaan Shopee.
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Şişik, Fatih, and Eser Sert. "Support Vector Machine working on FPGA and the segmentation method of brain MR screening." International Journal of Innovative Research in Education 4, no. 3 (October 17, 2017): 120. http://dx.doi.org/10.18844/ijire.v4i3.2549.
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Alan Programlanabilir Kapı Dizileri (Field Programmable Gate Array-FPGA) programlanabilir sayısal bloklar ve bağlantılarını içeren cihazlar olup çok esnek ve hızlı çalışabilme özelliklerine sahiptir. Programlanabilen bu sayısal kapılar sayesinde karmaşık tasarımlar kolay bir şekilde geliştirilebilmektedir. FPGA’lar küçük boyutlarda olup bilgisayardan bağımsız mobil olarak ve bilgisayarlardan daha yüksek hızlarda çalışabilmektedirler. Veri madenciliğinin görevlerinden biri olan sınıflandırma probleminin çözümü için geliştirilmiş önemli makine öğrenimi algoritmalarından biri Destek Vektör Makineleri’ dir. Literatürde Destek Vektör Makineleri’ nin diğer birçok tekniğe göre daha başarılı sonuçlar verdiği kanıtlanmıştır. Tümör analizi, yüz tanıma, robotik göz oluşturma gibi konular, araştırmacıların görüntü işleme alanında yoğun olarak üzerinde çalıştıkları güncel, önemli ve zor problemlerden bazılarıdır. Bilgisayarda yapılan tümör analizinde, grafik ve resimlerin işlenmesinde yavaş işlem yapma ve aynı zamanda mobil olmama sorunlarından, FPGA donanımı ile görüntü işlemede bu sorunların üstesinden gelinmektedir. Bu çalışmada FPGA donanımında çalışan destek vektör makinası kullanılarak daha gerçekçi tümör analizi yapılarak tümörlü bölgelerin bulunması ve gerekli analiz sonuçlarının gösterilmesi amaçlanmaktadır. Böylece sağlık alanında da kullanılabilecek yararlı bir donanımın tasarımı gerçekleştirilecektir. Dolayısıyla gömülü sistemlerle anlatılan bu işlem süreçlerini gerçekleştiren çalışma sayısı çok az olduğundan çalışma özgün değer taşımaktadır. Buna ek olarak, FPGA’ ya özgü donanım tanımlama dillerinden biri olan Çok Yüksek Hızlı Tümleşik Devre Tanımlama Dili (Very High Speed Integrated Circuit Hardware Description Language- VHDL) kullanılacaktır. Bölütleme sonucunun değerlendirilmesi için Uniformity Measure (UM) kullanılmıştır. UM değerlendirme sonucunun başarılı olduğu görülmüştür.
Anahtar Kelimeler: Alan Programlanabilir Kapı Dizileri, FPGA, çok yüksek hızlı tümleşik devre tanımlama dili, vhdl, segmentasyon, destek vektör makinesi
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Sri Sartini, Amirullah, and Aszrul AB. "Effects of Brain Gymnastics on Decreased Stress Levels in College Students." Comprehensive Health Care 5, no. 2 (August 21, 2021): 56–65. http://dx.doi.org/10.37362/jch.v5i2.594.
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The background of this study is non-pharmacological management to reduce stress one of which is brain gymnastics. Brain gymnastic movements can activate the neocortex and sympathetic nerves to reduce the increased production of adrenaline hormones in the body that can relieve psychological tension as well as physical tension. The purpose of this study is to find out the effect of brain gymnastics on the decrease in stress levels in students of the final level of the DIII Health Analyst Stikes Panrita Husada Bulukumba in 2019. The method used in this research using a pre-experiment research design with the one-group pre-post test design method. Sampling by means of Nonprobability sampling: Consecutive sampling with a total of 28 respondents. Measurement of stress levels using a watershed questionnaire (Depression Anxiety Stress Scale) with statistical tests used is a paired t-test. The results of this study showed that there was an effect of brain gymnastics exercise on the decrease in stress levels in students of the final level of the DIII Health Analyst Stikes Panrita Husada Bulukumba with a mean Pretest score of 22.61 while the mean Postest 12.75 so that the average value of changes in pretest and posttest stress levels with a mean value of 9,857 with an std. deviation of 3,354. In conclusion, there is a meaningful influence on brain gymnastics training on the decrease in stress levels in students of the final level of the DIII Health Analyst Stikes Panrita Husada Bulukumba 2019.
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Situmorang, Silvia Betrice, and Haris Herdiansyah. "Brand Ambassadors' Influence on Brand Image and Consumer Purchasing Decisions." Expose: Jurnal Ilmu Komunikasi 5, no. 1 (April 30, 2022): 64. http://dx.doi.org/10.33021/exp.v5i1.1589.
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<p class="abstract">E-commerce has recently grown in popularity, particularly in Indonesia. Indonesia is the Southeast Asian country with the highest number of e-commerce visitors. Shopee and Tokopedia are currently the two largest e-commerce platforms in Indonesia. Shopee is a Singaporean company, and Tokopedia is an Indonesian company. To expand their market, both are currently using a brand ambassador, Shopee with <em>Didi Kempot</em> and Tokopedia with BTS. As a result, the researchers conducted this study to determine the influence of those brand ambassadors on brand image and consumer purchasing decisions, and they compared Shopee and Tokopedia to determine which one influenced them the most. This study included 222 respondents drawn from a population of young Indonesian college students using convenience sampling. To test the hypothesis, a simple linear regression analysis was used. This study discovered that Brand Ambassador <em>Didi Kempot</em> had an influence on Brand Image (sig. 2-tailed = 0.000 with R2 = 0.124) and Shopee Consumer Buying Decision (sig. 2-tailed = 0.000 with R2 = 0.062) and Brand Ambassador BTS had an influence on Brand Image (sig. 2-tailed = 0.000 with R2 = 0.243) and Tokopedia Consumer Buying Decision (sig. 2-tailed = 0.000 with R2 = 0.059). Furthermore, all independent variables had a positive influence on all dependent variables. The source of R2 demonstrated that all dependent variables were positive.</p>
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E-Vahdati, Sahar, Wan Nordin Wan-Hussin, and Oon Hun Ling. "Sustaining the Yellow Heart: responsible business by reducing inequalities at Digi Malaysia." Emerald Emerging Markets Case Studies 12, no. 1 (February 2, 2022): 1–43. http://dx.doi.org/10.1108/eemcs-10-2020-0362.
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Learning outcomes This study enables to critique the development of a sustainability strategy brand; integrated reports, sustainability reports, usage of safe internet and online learning skills to reduce inequalities and increase stakeholders’ values. Case overview/synopsis Digi Telecommunications (Digi) has been publishing annual sustainability reporting in line with Global Reporting Initiatives since 2009. Albern Murty, Chief Executive Officer (CEO) of Digi, the largest player in the mobile telecommunications industry in Malaysia by the number of subscribers, decided to establish a responsible business brand known as Yellow Heart in 2018 to better serve their stakeholders demand. There was a low stakeholder understanding of Digi’s sustainability efforts and societal impacts. Digi’s Sustainability department aspired to make Yellow Heart the best industry practice for continuous improvements by making Responsible Business commitment one of the main pillars of the company’s strategy and vision. Yellow Heart was linked to Sustainable Development Goals (SDG)10 on reducing inequalities by focusing on Digital Inclusion and Resilience to increase safe access opportunities, provide marginalized communities with opportunities to pursue interests in digital learning pathways and create a more sustainable digital future for all. The case study illustrates the sustainability management at Digi and the planned migration from sustainability reporting to integrated reporting to build trust in the business with all the stakeholders. The case dilemma involves the challenges that Philip Ling Oon Hun, the Head of the Sustainability, faced in deciding the SDGs to focus on and measuring and reporting their outcomes to contribute to the greater good, not only in pure business terms but also to society at large. Complexity academic level This case is appropriate for undergraduate or graduate-level programs in Accounting, Corporate Governance and Strategy Implementation. Supplementary materials Teaching notes are available for educators only. Subject code CSS 1: Accounting and Finance.
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Alves, Tomas da Costa, Luh Komang Candra Dewi Dewi, and Augusto da Conceição Soares. "The Effect of Quality Service, Brand Image and Tuition Fees on Student Loyalty Mediated by Student Satisfaction at Instituto Profissional De Canossa, Dili, Timor Leste." Journal of Digitainability, Realism & Mastery (DREAM) 1, no. 02 (July 8, 2022): 16–26. http://dx.doi.org/10.56982/journalo.v1i02.17.
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Higher education is a sector that has contribution in producing competent and dedicated graduates for the nation and state. Universities that are less qualified will gradually be threatened with their existence. Universities need to be heedful to situations and conditions and are expected to be able to see the needs and desires of students as service users. The purpose of this research is to test and explain; the effect of quality service on student satisfaction, the effect of brand image on student satisfaction, the effect of tuition fees on student satisfaction, the effect of quality service on student loyalty, the effect of tuition fees on student loyalty, the effect of brand image on student loyalty, the effect of student satisfaction on student loyalty, the effect of quality service on student loyalty is mediated by student satisfaction, the effect of brand image on student loyalty is mediated by student satisfaction, the effect of tuition fees on student loyalty is mediated by student satisfaction. This research is a relationship/correlational research. The population in this study composed of 359 students. The sampling procedure used non-probability sampling with a purposive sampling method with a total sample of 125 students. Data collection techniques were carried out through questionnaires, interviews and documentation. The data obtained was then analyzed using descriptive statistics and inferential statistics with Smart-PLS analysis. The results showed that; quality service has a positive and significant effect on student satisfaction, brand image has a positive and significant effect on student satisfaction, tuition fees have no effect on student satisfaction, quality service has no effect on student loyalty, brand image has no effect on student loyalty, tuition fees have no effect on loyalty students, student satisfaction has a positive and significant effect on student loyalty, service quality has an effect on loyalty through student satisfaction, brand image has a positive and significant effect on loyalty through student satisfaction, and tuition fees have no effect on loyalty through student satisfaction. It is expected that further researchers will conduct research by adding other variables not discussed in this study.
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Gomes, Florindo Cardoso, Ferdi Antonio, Perpetua Ana Mery Estela Laot, and Eva Estrelita Cardoso Gomes. "The impact of social media marketing efforts on visit intention: a case study in Flodova Clinic, Dili, Timor Leste." Bali Medical Journal 12, no. 2 (August 9, 2023): 2320–29. http://dx.doi.org/10.15562/bmj.v12i2.4570.
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Link of Video Abstract: https://youtu.be/iDWJ07s4En8 Background: The utilization of social media in digital marketing offers various benefits, notably improved accessibility and the ability to disseminate information widely among diverse populations. Notably, social media has emerged as the leading marketing strategy to generate interest among people visiting healthcare facilities in Timor Leste. This study examines the impact of Social Media Marketing Efforts (SMME) on visit intentions through Flodova Clinic's Facebook page in Timor Leste. The mediating factors of brand image and online trust are investigated while controlling for health threats and gender. Methods: The study collects data from visitors and Facebook followers of Flodova Clinic. A cross-sectional data collection was done through an online survey. The analysis includes 184 samples that meet the inclusion criteria, employing Partial Least Squares Structural Equation Modeling (PLS-SEM). Results: The findings demonstrate a significant influence of SMME on visit intentions, indicating its efficacy in attracting potential visitors. However, no direct or mediating effects are observed on brand image and online trust. The study identifies the most influential domains of SMME, with electronic word of mouth (EWOM) having the most substantial impact, followed by entertainment and interaction. Additionally, health threats and gender are found to affect visit intentions significantly. Health threats positively influence patients' intent to visit, while females show comparatively lower interest in visiting the Flodova clinic. Conclusions: These results have managerial implications for developing SMME strategies in marketing health clinics, mainly through social media platforms like Facebook. The study underscores the importance of leveraging electronic word of mouth, entertainment, and interactive elements to maximize the effectiveness of SMME strategies. Additionally, it emphasizes the need for tailored approaches considering health threats and gender differences to optimize visit intentions and enhance engagement.
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Ağanəhməd qızı Mirzəyeva, Arzu. "What our bady language tells." SCIENTIFIC WORK 78, no. 5 (May 17, 2022): 38–43. http://dx.doi.org/10.36719/2663-4619/78/38-43.
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"Bədən dili" insanın emosional vəziyyətinin xarici təzahürüdür. Bu özünü mimika və jestlərdə ifadə edir. İnsani qaməti də, yerişi də jestikulyasiyaya daxildir. "Görünüş" adlandırdığımız bu obraz öz sahibi, onun emosional xüsusiyyətləri haqqında informasiya ötürür. Sifətin diaqnostikası zamanı insanın emosional vəziyyətini,sağlamlığını, psixoloji durumunu müəyyən etmək olur. Qaşlar, gözlər, burun, çənə və qulaqlara görə insanın xarakteri müəyyənləşdirilir. İnsanın təbəssümünün və gülüşünün öz möcüzəsi və mənası var. Gözlərin quruluş və formasından başlamış, baxışların növlərinə qədər insanın fikirlərini, danışığını və davranışını idarə edir. Başın, qolların, əllərin, ayaqların duruşu da insan haqqında informasiya ötürür. Beyinlə əllər arasındakı bağlar, digər orqanlar arasındakı bağlardan çoxdur. Sual olunur: Siz görüşdüyünüz adamın əlini necə sıxırsınız? Hakimiyyət, nüfuz, itaət - hamısı buradan başlayır, yəni ilk görüşdən. Məşhur Xəfiyyə Şerlok Holmosun təbirincə desək, insanın hansı peşə sahibi olduğunu onun dırnaqlarına, paltosunun, köynəyinin qollarına, ayaqqabılarına, şalvarının dizlərinə, barmaqlarındakı döyənəklərə, üzünün ifadəsinə baxan kimi bilmək olur. "Bədən dili"ni öyrənmək nəyin niyə baş verdiyini dərk etməyimizə kömək etdiyi üçün, yaşamağı asanlaşdırır. Ünsiyyət zamanı daha gözüaçıq olmaq başqalarını və nəticədə özümüzü daha dərindən, yaxşı anlamağı öyrətməkdir. Açar sözlər: bədən dili, emosiya, nitq, mimika, jestikulyasiya Arzu Aganahmad Mirzayeva What our bady language tells Abstract "Body language" is an external manifestation of a person's emotional state. It manifests itself in facial expressions and gestures. Gesticulation include both posture and gait. This image, which we call "appearance", conveys information about its owner, its emotional characteristics. During the diagnosis of the face, it is possible to determine the emotional state, health and psychological state of the person. Eyebrows, eyes, nose, chin and ears determine a person's character. A person's smile and laughter have their own miracle and meaning. It controls a person's thoughts, speech, and behavior, from the structure and shape of the eyes to the types of views. The position of the head, arms, hands and feet also convey information about a person.The connections between the brain and the hands are greater than the connections between other organs. The question is: How do you shake the hand of the person you meet? Power, authority, obedience - it all starts here, that is, from the first meeting. According to the famous detective Sherlock Holmes, it is possible to know a person's profession by looking at his nails, coat, sleeves, shoes, knees of his pants, bruises on his fingers, facial expressions. Learning body language helps us to understand why things happen and makes life easier. It is to teach us to be more open in communication, to understand others and, as a result, ourselves better. Key words: body language, emotion, speech, mimicry,pantomime, gesture
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Pereira, Grinaldo Vicente, Luh Komang Candra Dewi, and Augusto da Conceição Soares. "The Influence of Marketing Mix and Service Quality on Purchasing Decisions Mediated by Consumer Satisfaction at Timor Telecom." Journal of Digitainability, Realism & Mastery (DREAM) 3, no. 02 (February 29, 2024): 8–21. http://dx.doi.org/10.56982/dream.v3i02.204.
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This research aims to determine and analyze the influence of the marketing mix and service quality on purchasing decisions through consumer satisfaction at Timor Telcom Dili Timor Leste. The population in this research is countless customers of Timor Telcom products. The sample size for this research was 100 respondents, who were randomly selected using a technique known as accidental sampling. The data collection techniques include observation, questionnaires, documentation, and a literature study. The data analysis technique in this research uses SMART-PLS. The findings of this research show that: 1) The marketing mix has no effect on consumer satisfaction, 2) Service quality has an effect on consumer satisfaction, 3) Marketing mix has an effect on purchasing decisions, 4) Service quality has no effect on purchasing decisions, 5) Consumer satisfaction has an effect on purchasing decisions, 6) Consumer satisfaction is not able to mediate the influence of the marketing mix on purchasing decisions, 7) Consumer satisfaction can mediate the influence of service quality on purchasing decisions. Conclusion: Despite the limitations of this study, it has several shortcomings in influencing consumer interest in telecommunication services offered by the Timor Telecom Company. Therefore, future researchers are recommended to expand this study and examine other variables, such as product quality, brand image, and brand trust, that were not examined in this research.
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Ercan, Hüseyin Onur. "Türklere Karşı Zafer Kehaneti Yahut Propaganda: Alman Hümanisti Sebastian Brant’ın Kayzer I. Maximilian’ı Savaşa Teşvik İçin Yazdıkları (1494-1501)." Belleten 87, no. 310 (December 1, 2023): 889–917. http://dx.doi.org/10.37879/belleten.2023.889.
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Almanya’nın en önemli hümanistleri arasında yer alan Sebastian Brant, Latince ve Almanca kaleme aldığı yazılarında, ayrıca resimli broşür/el ilanı olarak dağıtılan çok sayıda şiirinde I. Maximilian’ı Kutsal Roma Alman İmparatorluğu’nu düzene sokmaya, kilisede reform yapmaya ve Fransızlar ile Türklerin yayılmasına karşı savaşmaya teşvik etmiştir. Bu makale esas itibarıyla Alman hukukçu ve hümanisti Sebastian Brant’ın özellikle Habsburg İmparatoru I. Maximilian döneminde Türkler ve İslâm aleyhine yazdığı metinlerin, tarihî arka planı gözeterek, propaganda dili ve Osmanlılara karşı sefer düzenlenmesi açısından değerlendirmesinden oluşmaktadır. Brant’ın Türk temasını işlediği ve 1494-1513 yılları arasına tekabül eden yayınları içerisinden -hâkim rengi göstermesi bakımından yeterli ölçüde fikir verici- dördü üzerinde durulmuştur: Das Narrenschiff (1494), De origine (1495), Thurcorum terror et potentia (1498), Von der Vereinigung der Könige und Anschlag an die Türken (1501). Bu yayın aralığının aslında II. Bayezid dönemine, Osmanlıların Batı politikalarına daha çok ağırlık vermeyi tercih ettiğinin görüldüğü yıllara rastlamış olması, özellikle Mora seferlerinin getirdiği hava içinde yerini bulması dikkat çekicidir. Bir başka ifadeyle dönemin atmosferinin, I. Maximilian dönemindeki Haçlı seferi çalışmaları bağlamı içinde olan bu literatürün ortaya çıkmasında büyük önem taşıdığı söylenebilir.
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Wulandari, Dyah Ayu, and Anisatul Muawanah. "BRAIN GYM DAPAT MERINGANKAN NYERI DISMENORE." Jurnal SMART Kebidanan 5, no. 1 (August 2, 2018): 21. http://dx.doi.org/10.34310/sjkb.v5i1.142.
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Menstruasi merupakan perubahan fisiologis pada wanita yang terjadi secara berkala dan dipengaruhi oleh hormon reproduksi. Periode ini penting dalam hal reproduksi, biasanya terjadi setiap bulan antara remaja sampai menopause. Prevalensi kejadian dismenore terjadi hampir pada semua wanita. Dengan rata-rata lebih dari 50% wanita disetiap Negara mengalami dismenore. Pada umumnya 50-60% wanita diantaranya memerlukan obat-obatan analgesik dan beberapa terapi untuk mengatasi dismenore. Ada berbagai cara atau metode yang digunakan untuk mengalihkan perhatian terhadap rasa nyeri yang dialaminya, antara lain: distraksi visual, distraksi pendengaran,distraksi pernafasan, tehnik pernafasan, imajinasi terbimbing, distraksi intelektual salah satunya adalah brain gym. Brain gym merupakan sebuah senam yang tujuan utamanya untukmempertahankan kesehatan otak dengancara melakukan gerakan badan. Penelitian ini bertujuan untuk mengetahuai pengaruh Brain Gym terhadap nyeri dismenore pada mahasiswa DIII Keperawatan STIKes Karya Husada Semarang. Quasi Eksperimental dengan rancangan one group pre and post test. Jumlah sampel 38 responden. dan analisis yang digunakan adalah Wilcoxon. diperoleh rerata sebelum sebesar 3.26 dan sesudah 5.92. Hasil uji Wilcoxon Signed Rank Test dengan nilai p = 0,000, <α (0,05). Ada pengaruh Brain Gym terhadap penurunan nyeri dismenore pada mahasiswi D III Keperawatan Tingkat 1 STIKes Karya Husada Semarang.Kata kunci : Brain Gym dan Dismenore
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Et. al., Khyrinaairinfariza Abu Samah,. "Naïve Bayes Twitter Sentiment Analysis In Visualizing The Reputation Of Communication Service Providers: During Covid-19 Pandemic." Turkish Journal of Computer and Mathematics Education (TURCOMAT) 12, no. 5 (April 10, 2021): 1753–64. http://dx.doi.org/10.17762/turcomat.v12i5.2176.
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We present the real-world public sentiment expressed on Twitter using the proposed conceptual model (CM) to visualize the communication service providers (CSP) reputation during the Covid-19 pandemic in Malaysia from March 18 until August 18, 2020. The CM is a guideline that entails public tweets directly or indirectly mentioned to the three biggest CSP in Malaysia: Celcom, Maxis, and Digi. A text classifier model optimized for short snippets like tweets is developed to make bilingual sentiment analysis possible. The two languages explored are Bahasa Malaysia and English since they are the two most spoken languages in Malaysia. The classifier model is trained and tested on a huge multidomain dataset pre-labeled with the labels “0” and “1”, which resemble “positive” and “negative”, respectively. We used the Naïve Bayes (NB) technique as the core of the classifier model. Functionality testing has done to ensure no significant error that will render the application useless, and the accuracy testing score of 89% is considered quite impressive. We came out with the visualization through the word clouds and presented -56%, -42%, and -43% of Net Brand Reputation for Celcom, Maxis, and Digi.
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Unal, Guler, Emily Marquez, Mara H. O'brien, Pericles Stavropoulos, and Ian P. Callard. "Expression of cytochrome P450 aromatase isoforms in female Alburnus tarichi (Guldenstaedtii, 1814)." Ege Journal of Fisheries and Aquatic Sciences 38, no. 2 (June 15, 2021): 247–52. http://dx.doi.org/10.12714/egejfas.38.2.15.
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In this study, we aimed to clone brain-derived Cyp19b and ovary-derived Cyp19a the P450 aromatase gene isoforms and to indicate the expression levels of these genes in the hypothalamus and ovary tissues from reproductively arrested ovarian development (RA) and non-arrested ovarian development (RN) Alburnus tarichi from Lake Van, Turkey. The expression levels of Cyp19b and Cyp19a genes were predominant in the hypothalamus and ovary, respectively. The level of Cyp19b mRNA was significantly lower in the hypothalamus and ovary from RA fish than in the hypothalamus and ovary from RN fish (P<0.05). The expression level of Cyp19a was significantly lower in the ovary of RA fish (P<0.05) than RN fish while no difference was found in the hypothalamus of both RA and RN fish (P<0.05). According to these findings, we suggest that the RA fish represent a segment of the population and these fish may be more sensitive to endocrine disruption compound/s than others.
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Broughton, Susan J., Cathy Slack, Nazif Alic, Athanasios Metaxakis, Timothy M. Bass, Yasmine Driege, and Linda Partridge. "DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition." Aging Cell 9, no. 3 (February 12, 2010): 336–46. http://dx.doi.org/10.1111/j.1474-9726.2010.00558.x.
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Pinar, Yunus, Nihal Kubilay Pinar, and Bengul Cetintas. "FIRST AND SECOND LANGUAGE DEVELOPMENT IN YOUNG CHILDREN AND BILINGUALISM IN LIGHT OF LINGUISTICS, NEUROLINGUISTICS AND FINDINGS FROM BRAIN RESEARCH." Idil Journal of Art and Language 4, no. 18 (October 20, 2015): 1–23. http://dx.doi.org/10.7816/idil-04-18-01.
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Paranavitana, Suresh. "Digi - Insurance – the Case Story of the Potential in the Life Insurance of Sri Lanka." Jurnal Ilmu Keuangan dan Perbankan (JIKA) 13, no. 1 (December 29, 2023): 1–10. http://dx.doi.org/10.34010/jika.v13i1.10161.
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This study aims to see how insurance products are developed by life insurance companies operating in Sri Lanka, providing products that are acceptable in the markets where they operate. The essence of this paper is to highlight the ability of direct communication between the insured and the insurer through digital transformation and in facilitating direct (premium payment) transactions between the insured and the insurer through their respective banks. This research uses qualitative research methods with descriptive methods. The research results show that insurance plays a major role in developing life insurance products and is a liaison between the insurer and the insured and in certain cases a facilitator to collect premiums on behalf of the insurer. Keywords: Brand Communication; Digital Transformation; Insurance Industry Sri Lanka; Life Insurance; Linking Insured and Insurer; Marketing Communication Abstrak This study aims to see how insurance products are developed by life insurance companies operating in Sri Lanka, providing products that are acceptable in the markets where they operate. The essence of this paper is to highlight the ability of direct communication between the insured and the insurer through digital transformation and in facilitating direct (premium payment) transactions between the insured and the insurer through their respective banks. This research uses qualitative research methods with descriptive methods. The research results show that insurance plays a major role in developing life insurance products and is a liaison between the insurer and the insured and in certain cases a facilitator to collect premiums on behalf of the insurer. Kata Kunci: Komunikasi Merek; Transformasi Digital; Industri Asuransi Sri Lanka; Asuransi Jiwa; Menghubungkan Tertanggung Dan Penanggung; Komunikasi Pemasaran
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Mandal, Dilip Kumar. "Mother-Kid Bonding in Goats: A Very Important Issue for Kids’ Survival and Performance Dilip Kumar Mandal* , Ajoy Das, Asish Debbarma and S." Corpus Journal of Dairy and Veterinary Science (CJDVS) 3, no. 2 (May 16, 2022): 1–5. http://dx.doi.org/10.54026/cjdvs1040.
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Mother-offspring attachment is a crucial determinant for the survival of offspring. These relationships are supported by various factors such as hormone, olfaction cues, chemosensory stimuli, acoustic recognition etc. during early phase of bonding. Bonding occurs at various stages, in numerous brain structures, and the release of certain hormone allows the development of early learning and recognition abilities between mother and kid. It is evident that a selective and exclusive attachment forms between the mother and kids within few hours of parturition. Oxytocin and prolactin are two major hormones play key roles in expression of maternal behaviors and bond formation. Smelling, licking and grooming are vital activities in the establishment of unique olfactory memory in the mother for her offspring. Primiparous goats may delay nursing to neonates with aggressive/rejection behavior when compared to multiparous. Human meddling, drug and other stimulations from the natural environment are the causal factors for breakdown of connections between the mother and kids. During the first week of life, interruptions in mother’s care, maternal selectivity, and failure in mutual recognition may have a negative impact on the newborn’s survival and future performance.
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Fulk, George D., Stephanie A. Combs, Kelly A. Danks, Coby D. Nirider, Bhavana Raja, and Darcy S. Reisman. "Accuracy of 2 Activity Monitors in Detecting Steps in People With Stroke and Traumatic Brain Injury." Physical Therapy 94, no. 2 (February 1, 2014): 222–29. http://dx.doi.org/10.2522/ptj.20120525.
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Background Advances in sensor technologies and signal processing techniques provide a method to accurately measure walking activity in the home and community. Activity monitors geared toward consumer or patient use may be an alternative to more expensive monitors designed for research to measure stepping activity. Objective The objective of this study was to examine the accuracy of 2 consumer/patient activity monitors, the Fitbit Ultra and the Nike+ Fuelband, in identifying stepping activity in people with stroke and traumatic brain injury (TBI). Secondarily, the study sought to compare the accuracy of these 2 activity monitors with that of the StepWatch Activity Monitor (SAM) and a pedometer, the Yamax Digi-Walker SW-701 pedometer (YDWP). Design A cross-sectional design was used for this study. Method People with chronic stroke and TBI wore the 4 activity monitors while they performed the Two-Minute Walk Test (2MWT), during which they were videotaped. Activity monitor estimated steps taken were compared with actual steps taken counted from videotape. Accuracy and agreement between activity monitor estimated steps and actual steps were examined using intraclass correlation coefficients (ICC [2,1]) and the Bland-Altman method. Results The SAM demonstrated the greatest accuracy (ICC [2,1]=.97, mean difference between actual steps and SAM estimated steps=4.7 steps) followed by the Fitbit Ultra (ICC [2,1]=.73, mean difference between actual steps and Fitbit Ultra estimated steps=−9.7 steps), the YDWP (ICC [2,1]=.42, mean difference between actual steps and YDWP estimated steps=−28.8 steps), and the Nike+ Fuelband (ICC [2,1]=.20, mean difference between actual steps and Nike+ Fuelband estimated steps=−66.2 steps). Limitations Walking activity was measured over a short distance in a closed environment, and participants were high functioning ambulators, with a mean gait speed of 0.93 m/s. Conclusions The Fitbit Ultra may be a low-cost alternative to measure the stepping activity in level, predictable environments of people with stroke and TBI who can walk at speeds ≥0.58 m/s.
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Nurhidayati, Novita, and Mardianingsih . "KEBERHASILAN BOUNDING ATTACHMENT MELALUI PROSES INISIASI MENYUSUI DINI." Jurnal Kebidanan 10, no. 02 (December 31, 2018): 153. http://dx.doi.org/10.35872/jurkeb.v10i02.288.
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Novita Nurhidayati 1) Mardianingsih2)1),2) Prodi DIII Kebidanan Sekolah Tinggi Ilmu Kesehatan Estu UtomoEmail: novita1259@gmail.comABSTRAKLatar Belakang :Ikatan kasih sayang antara ibu dan anak sangatlah penting, tidak adanya ikatan kasih sayang antara ibu dan anak atau bounding attachment pada ibu dan bayi menyebabkan kurangnya proses perkembangan otak bayi karena tidak diberikan stimulus yang positif oleh ibunya. Salah satu hal yang dapat mendukung proses bounding attachment adalah inisiasi menyusu dini. Tujuan Penelitian :Penelitian ini bertujuan untuk mengetahui hubungan inisiasi menyusu dini dengan keberhasilan bounding attachment. Metode Penelitian :Penelitian yang dilakukan menggunakan metode survey analitik dan pendekatan waktu cross sectional. Populasi penelitian ini yaitu ibu nifaspada bulan April-Juni 2017 di BPS Tutik, Cabean, Boyolali sebanyak 31 responden, pengambilan sampel dengan total sampling dan analisa data chi square. Hasil Penelitian :Hasil penelitian didapatkan dari 20 responden yang dilakukan inisiasi menyusu dini terdapat 18 responden yang bounding attachment positif.Hasil perhitungan chi square dengan α = 0,05, p value (0,002< 0,05), berarti Ha diterima dan Ho ditolak. Simpulan :Dari penelitian ini dapat disimpulkan bahwa ada hubungan inisiasi menyusu dini dengan keberhasilan bounding attachment.Kata Kunci :Inisiasi menyusu dini, Keberhasilan bounding attachmentRELATIONSHIP EARLY INITIATION OF BREASTFEEDING WITH BOUNDING SUCCESS ATTACHMENTSABSTRACTBackground : Bond of love between mother and child or bounding attachment in mothers and infants causing lack the baby’s brain development because there is a positive stimulus given by his mother. One of the things that can contribute to the bounding attachment is early initiation of breastfeeding. Purposes : This study aims to determine the relationship of early initiation of breastfeeding with bounding success attachments. Research method : Research conducted using survey methods of analytic and cross sectional approach.This study population is women giving birth in April-Juni 2017 in the BPS Tutik, Cabean, Cepogo, total sampling with sampling and data analysis chi square. Result: The results obtained from the 20 respondents who made early breastfeeding initiation, there are 18 respondents who bounding positive attachment. Chi square calculation results with α = 0.05, p value (0.002 <0.05), mean Ha Ho accepted and rejected. Conclude : From this study it can be concluded that there is a connection with the early initiation of breastfeeding success bounding attachment.keyword :Early initiation of breastfeeding, Bounding succes attachments
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Reynolds, Charles F. "Commentary on “Individual and Societal Wisdom: Explaining the Paradox of Human Aging and High Well-Being” by Dilip V. Jeste and Andrew J. Oswald: Individual and Societal Wisdom in Later Life: The Search for Brain Health." Psychiatry: Interpersonal and Biological Processes 77, no. 4 (December 2014): 331–32. http://dx.doi.org/10.1521/psyc.2014.77.4.331.
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Fitri Fadilah Widyaputri and Edy Yusuf Agung Gunanto. "Shariah Mobile Banking Adoption Trends: Analysis Mob Mentality, Reputation, Perceived Risk, and Islamic Financial Literacy." Jurnal Ekonomi Syariah Teori dan Terapan 10, no. 5 (September 30, 2023): 482–95. http://dx.doi.org/10.20473/vol10iss20235pp482-495.
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ABSTRACTThis study aimed to analyze the factors that influence customer decisions in using Islamic mobile banking services. In this study, a total of 200 respondents were collected through purposive sampling technique with the criteria of having used or currently using mobile banking services from Islamic banks in Semarang City, respondents answered online surveys through google forms as primary data collection. The methodology in this study was using PLS-SEM. The study findings show that the factors of mob mentality, reputation, perceived risk, and Islamic financial literacy have a positive and significant influence on the decision to use Islamic mobile banking. The four factors have a total influence of 87% on the decision to use Islamic mobile banking services. This finding implies that these factors need to be considered by customers and banks. Islamic banking must continue to strive for a level of security, data confidentiality and customer trust in a more creative, convenient, and effective mobile banking features and services system so that customers still feel their decision to use Islamic mobile banking services is right.Keywords: Mob Mentality, Reputation, Perceived Risk, Islamic Financial Literacy. ABSTRAKStudi ini memiliki tujuan untuk menganalisis faktor-faktor yang berpengaruh terhadap keputusan nasabah dalam menggunakan layanan mobile banking syariah. Pada studi ini, dikumpulkan sejumlah 200 responden melalui teknik purposive sampling dengan kriteria pernah atau sedang menggunakan layanan mobile banking dari bank syariah di Kota Semarang, responden menjawab survei secara online melalui google forms sebagai pengumpulan data primer. Metodologi pada penelitian ini yaitu menggunakan PLS-SEM. Hasilnya menunjukkan bahwa faktor-faktor mentalitas gerombolan, reputasi, persepsi akan resiko, dan literasi keuangan syariah memiliki pengaruh positif dan signifikan terhadap keputusan penggunaan mobile banking syariah. Keempat faktor tersebut memiliki total pengaruh sebesar 87% terhadap keputusan penggunaan layanan mobile banking syariah. Penemuan ini memberikan implikasi bahwa faktor-faktor tersebut perlu dipertimbangkan oleh nasabah dan pihak perbankan. Perbankan syariah harus tetap mengupayakan tingkat keamanan, kerahasiaan data dan kepercayaan nasabah dalam sistem fitur dan layanan mobile banking yang lebih kreatif, nyaman, serta efektif agar nasabah tetap merasa keputusannya menggunakan layanan mobile banking syariah adalah tepat.Kata Kunci: Mob Mentality, Reputation, Perceived Risk, Islamic Financial Literacy. REFFERENCES Alkhowaiter, W. A. (2020). Digital payment and banking adoption research in Gulf countries: A systematic literature review. 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Selection and ranking of perceived risk associated with mobile banking in West Africa. An AHP Approach from customers’ perspective. International Journal of Scientific & Engineering Research, 7(1), 80-86. Ghozali, I. (2014). Partial least squares, konsep, teknik, dan aplikasi menggunakan program SmartPLS 3.2.9 untuk peneliti. Semarang: Badan Penerbit Universitas Diponegoro. Ichwan, A., & Ghofur, R. A. (2020). Pengaruh Technology Acceptance Model terhadap keputusan muzakki membayar zakat melalui fintech Gopay. Jurnal Ilmiah Ekonomi Islam, 6(02), 129–135. doi:10.29040/jiei.v6i2.1011 Khan, L., & Arif, I. (2022). Islamic financial literacy and intention to use Islamic banking: A role of financial considerations. Journal of Finance & Economics Research, 7(1), 47–59. doi:10.20547/jfer2207104 Kurniasih, P. (2019). Faktor-faktor yang mempengaruhi keputusan konsumen dalm membeli sayuran organik di Kota Salatiga. Theses of Undergraduate Faculty of Agriculture and Business. Universitas Kristen Satya Wacana. Linda & Bloom, C. (2017). The bandwagon effect. Retrieved from https://www.psychologytoday.com/us/blog/stronger-the-broken-places/201708/the-bandwagon-effect?amp Muhammad, M., Sirat, A. H., & Hadady, E. H. (2023). The effect of Islamic financial literacy on the decision to use Islamic banking services in the City of Ternate with religion as a moderating variable. Jurnal Manajemen Bisnis, 10(1), 177–189. doi:10.33096/jmb.v10i1.489 Narteh, B., & Braimah, M. (2020). Corporate reputation and retail bank selection: the moderating role of brand image. International Journal of Retail and Distribution Management, 48(2), 109–127. doi:10.1108/IJRDM-08-2017-0164 Nguyen, Y. T. H., Tapanainen, T., & Nguyen, H. T. T. (2022). Reputation and its consequences in Fintech services: the case of mobile banking. International Journal of Bank Marketing, 40(7), 1364–1397. doi:10.1108/IJBM-08-2021-0371 Pala, F., Erdoğdu, A., Ali, M., Alnori, F., & Barut, A. (2023). Analyzing the linkage between Islamic financial literacy and Islamic banking services adoption: Evidence from Turkey. Journal of Islamic Accounting and Business Research. doi:10.1108/JIABR-12-2021-0324 Rahim, S. H. A., Rashid, R. A., & Hamed, A. B. (2016). Islamic financial literacy and its determinants among university students: An exploratory factor analysis. International Journal of Economics and Financial Issues, 6(7S), 32–35. Roemanasari, F., Sabela, J., & Rusgianto, S. (2022). Islamic financial literacy and financial behavior on investment intention. Jurnal Ilmu Ekonomi Terapan, 7(2), 239–250. doi:10.20473/jiet.v7i2.40679 Tan, E., & Lau, J. L. (2016). Behavioural intention to adopt mobile banking among the millennial generation. Young Consumers, 17(1), 18-315. doi:10.1108/YC-07-2015-00537 Thapa, S., Guzmán, F., & Paswan, A. K. (2022). How isolation leads to purchasing luxury brands: The moderating effects of COVID-19 anxiety and social capital. Journal of Product and Brand Management, 31(6), 984–1001. doi:10.1108/JPBM-05-2021-3500 Yudistira, A. (2022). Pengaruh bandwagon effect,veblen effect, dan pendapatan terhadap keputusan pembelian sepeda di masa pandemi Covid-19. Jurnal Ilmiah Mahasiswa FEB Universitas Brawijaya, 10(2), 1-17.
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Mertinková, Patrícia, Evelína Mochnáčová, Katarína Bhide, Amod Kulkarni, Zuzana Tkáčová, Jana Hruškovicová, and Mangesh Bhide. "Development of peptides targeting receptor binding site of the envelope glycoprotein to contain the West Nile virus infection." Scientific Reports 11, no. 1 (October 11, 2021). http://dx.doi.org/10.1038/s41598-021-99696-w.
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AbstractWest Nile virus (WNV), re-emerging neurotropic flavivirus, can cross the blood–brain barrier (BBB) and cause fatal encephalitis and meningitis. Infection of the human brain microvascular endothelial cells (hBMECs), building blocks of the BBB, represents the pivotal step in neuroinvasion. Domain III (DIII) of the envelope (E) glycoprotein is a key receptor-binding domain, thus, it is an attractive target for anti-flavivirus strategies. Here, two combinatorial phage display peptide libraries, Ph.D.-C7C and Ph.D.-12, were panned against receptor-binding site (RBS) on DIII to isolate peptides that could block DIII. From series of pannings, nine peptides (seven 7-mer cyclic and two 12-mer linear) were selected and overexpressed in E. coli SHuffle T5. Presence of disulfide bond in 7-mer peptides was confirmed with thiol-reactive maleimide labeling. Except for linear peptide 19 (HYSWSWIAYSPG), all peptides proved to be DIII binders. Among all peptides, 4 cyclic peptides (CTKTDVHFC, CIHSSTRAC, CTYENHRTC, and CLAQSHPLC) showed significant blocking of the interaction between DIII and hBMECs, and ability to neutralize infection in cultured cells. None of these peptides showed toxic or hemolytic activity. Peptides identified in this study may serve as potential candidates for the development of novel antiviral therapeutics against WNV.
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Hruškovicová, Jana, Katarína Bhide, Patrícia Petroušková, Zuzana Tkáčová, Evelína Mochnáčová, Ján Čurlík, Mangesh Bhide, and Amod Kulkarni. "Engineering the Single Domain Antibodies Targeting Receptor Binding Motifs Within the Domain III of West Nile Virus Envelope Glycoprotein." Frontiers in Microbiology 13 (April 1, 2022). http://dx.doi.org/10.3389/fmicb.2022.801466.
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West Nile virus (WNV) is a mosquito-borne neurotrophic flavivirus causing mild febrile illness to severe encephalitis and acute flaccid paralysis with long-term or permanent neurological disorders. Due to the absence of targeted therapy or vaccines, there is a growing need to develop effective anti-WNV therapy. In this study, single-domain antibodies (sdAbs) were developed against the domain III (DIII) of WNV’s envelope glycoprotein to interrupt the interaction between DIII and the human brain microvascular endothelial cells (hBMEC). The peripheral blood mononuclear cells of the llama immunized with recombinant DIIIL297–S403 (rDIII) were used to generate a variable heavy chain only (VHH)-Escherichia coli library, and phage display was performed using the M13K07ΔpIII Hyperphages system. Phages displaying sdAbs against rDIII were panned with the synthetic analogs of the DIII receptor binding motifs, DIII-1G299–K307 and DIII-2V371–R388, and the VHH gene from the eluted phages was subcloned into E. coli SHuffle. Soluble sdAbs purified from 96 E. coli SHuffle clones were screened to identify 20 candidates strongly binding to the synthetic analogs of DIII-1G299–K307 and DIII-2V371–R388 on a dot blot assay. Among them, sdAbA1, sdAbA6, sdAbA9, and sdAbA10 blocked the interaction between rDIII and human brain microvascular endothelial cells (hBMECs) on Western blot and cell ELISA. However, optimum stability during the overexpression was noticed only for sdAbA10 and it also neutralized the WNV–like particles (WNV-VLP) in the Luciferase assay with an half maximal effective concentration (EC50) of 1.48 nm. Furthermore, the hemocompatibility and cytotoxicity of sdAbA10 were assessed by a hemolytic assay and XTT-based hBMEC proliferation assay resulting in 0.1% of hemolytic activity and 82% hBMEC viability, respectively. Therefore, the sdAbA10 targeting DIII-2V371–R388 of the WNV envelope glycoprotein is observed to be suitable for in vivo trials as a specific therapy for WNV–induced neuropathogenesis.
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ZACHARIA, MERIYA, SEENA P, KIRAN SHAJ, and NEIKHRIETSONUO KESIEZIE. "CLINICAL STUDY OF DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) – WITH SPECIAL FOCUS ON THE INCITING DRUG AND THE INDICATION FOR STARTING THE DRUG." Asian Journal of Pharmaceutical and Clinical Research, March 14, 2022, 34–37. http://dx.doi.org/10.22159/ajpcr.2022.v15i4.44035.
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Objective: This study was undertaken to identify the most common drug causing drug reaction with eosinophilia and systemic symptoms (DRESS) inpatients admitted in our center and possible factors associated with it. Methods: This was a cross-sectional observational study of patients with DRESS admitted from January 2018 to December 2020. Data were entered in MS Excel and analyzed using SPSS software. Results: Eighty-four consecutive patients who were diagnosed as DRESS were included in the study. The most common inciting drug was phenytoin and the most common indication for starting phenytoin was traumatic brain injury (TBI) to prevent seizures. DRESS to phenytoin after neurotrauma (NT) was more in patients who sustained combined extradural (EDH) and subdural hematoma (SDH), and those were managed conservatively for NT. None of the patients recognized fever as an initial feature of DRESS and did not stop the drug. More than one-third of patients with erythema multiforme (EM) like rash developed drug induced liver injury(DILI). The majority of patients who had sub-arachnoid hemorrhage (SAH) developed DILI. Conclusion: Phenytoin though time-tested and cost-effective for prevention of seizures after TBI, it very commonly leads to DRESS which adds to the morbidity and rarely mortality of patient. In this present era of increasing road traffic accidents, using newer non-aromatic anticonvulsants may be more beneficial than phenytoin. The patients should be made aware of the likely time DRESS can occur, the earliest symptom of DRESS, and the need to stop the drug at the earliest.
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Wu, Yanqin, and Wenzhong Zhu. "The Role of CSR Engagement in Customer-Company Identification and Behavioral Intention During the COVID-19 Pandemic." Frontiers in Psychology 12 (August 12, 2021). http://dx.doi.org/10.3389/fpsyg.2021.721410.
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The global coronavirus pandemic has reignited a strategic debate among the business community of the necessity for corporate social responsibility (CSR) engagement in the ever-dynamic social media. Considering the global economic downturn introduced by the COVID-19 pandemic, the present research is devoted to investigating whether CSR engagement in social media can help DiDi (a Chinese shared brand) at stake survive this overwhelming crisis. A theoretical model proposed to describe the hypothesized relationships was tested by a Structural Equation Modeling technique through the empirical online questionnaire. Through findings, we demonstrated that there was a positive relationship between CSR engagement of DiDi on WeChat, customer–company identification (C–C identification), and behavioral intention [purchase intention, brand loyalty, and e-word-of-mouth (eWOM)] of customers. With attention to psychological influence, our empirical statistics also evidenced the mediating role of C-C identification between CSR engagement and behavioral intention of customers. This study highlights the significant role of CSR engagement in a critical period theoretically and offers businesses more open innovation strategies to compete against the COVID-19 pandemic-induced market downturn.
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Bhide, Katarína, Evelína Mochnáčová, Zuzana Tkáčová, Patrícia Petroušková, Amod Kulkarni, and Mangesh Bhide. "Signaling events evoked by domain III of envelop glycoprotein of tick-borne encephalitis virus and West Nile virus in human brain microvascular endothelial cells." Scientific Reports 12, no. 1 (May 25, 2022). http://dx.doi.org/10.1038/s41598-022-13043-1.
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AbstractTick-borne encephalitis virus and West Nile virus can cross the blood–brain barrier via hematogenous route. The attachment of a virion to the cells of a neurovascular unit, which is mediated by domain III of glycoprotein E, initiates a series of events that may aid viral entry. Thus, we sought to uncover the post-attachment biological events elicited in brain microvascular endothelial cells by domain III. RNA sequencing of cells treated with DIII of TBEV and WNV showed significant alteration in the expression of 309 and 1076 genes, respectively. Pathway analysis revealed activation of the TAM receptor pathway. Several genes that regulate tight-junction integrity were also activated, including pro-inflammatory cytokines and chemokines, cell-adhesion molecules, claudins, and matrix metalloprotease (mainly ADAM17). Results also indicate activation of a pro-apoptotic pathway. TLR2 was upregulated in both cases, but MyD88 was not. In the case of TBEV DIII, a MyD88 independent pathway was activated. Furthermore, both cases showed dramatic dysregulation of IFN and IFN-induced genes. Results strongly suggest that the virus contact to the cell surface emanates a series of events namely viral attachment and diffusion, breakdown of tight junctions, induction of virus uptake, apoptosis, reorganization of the extracellular-matrix, and activation of the innate immune system.
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Wurmser, Maud, Mridula Muppavarapu, Christine Mary Tait, Christophe Laumonnerie, Luz María González-Castrillón, and Sara Ivy Wilson. "Robo2 Receptor Gates the Anatomical Divergence of Neurons Derived From a Common Precursor Origin." Frontiers in Cell and Developmental Biology 9 (June 23, 2021). http://dx.doi.org/10.3389/fcell.2021.668175.
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Sensory information relayed to the brain is dependent on complex, yet precise spatial organization of neurons. This anatomical complexity is generated during development from a surprisingly small number of neural stem cell domains. This raises the question of how neurons derived from a common precursor domain respond uniquely to their environment to elaborate correct spatial organization and connectivity. We addressed this question by exploiting genetically labeled mouse embryonic dorsal interneuron 1 (dI1) neurons that are derived from a common precursor domain and give rise to spinal projection neurons with distinct organization of cell bodies with axons projecting either commissurally (dI1c) or ipsilaterally (dI1i). In this study, we examined how the guidance receptor, Robo2, which is a canonical Robo receptor, influenced dI1 guidance during embryonic development. Robo2 was enriched in embryonic dI1i neurons, and loss of Robo2 resulted in misguidance of dI1i axons, whereas dI1c axons remained unperturbed within the mantle zone and ventral commissure. Further, Robo2 profoundly influenced dI1 cell body migration, a feature that was partly dependent on Slit2 signaling. These data suggest that dI1 neurons are dependent on Robo2 for their organization. This work integrated with the field support of a model whereby canonical Robo2 vs. non-canonical Robo3 receptor expression facilitates projection neurons derived from a common precursor domain to read out the tissue environment uniquely giving rise to correct anatomical organization.
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AKKAN, Gulden, and Selami Varol ÜLKER. "THE EFFECT OF VIOLENCE DIRECTED TO CHILDREN AND BRAIN DEVELOPMENT AND COGNITIVE PROCESSES." Gelişim ve Psikoloji Dergisi, December 27, 2023. http://dx.doi.org/10.51503/gpd.1275346.
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Son yıllarda gerek bireysel anlamda gerekse toplumlar nezninde şiddet vakalarının giderek arttığına tanıklık ediyoruz. Toplumsal kutuplaşmalar ve etnosentrik tutumların yanısıra bireylerarası saldırganlık ve şiddet vakaları da ( başta kadınlara ve çocuklara ) her geçen gün artmaktadır. Şiddetin insanlar arasında problem çözmede ‘’ araçsal kullanımı’’ modernleşme ile zıtlık içinde olmalı diye düşünürken tam tersi bir istatistik çıkıyor karşımıza. Saldırganlık ve şiddete olan eğilim, dürtüsel hareket her geçen gün artıyor. Şiddetin bu anlamda yaygınlığını değerlendirirken ve üzerinde düşünürken, bir anda örtülü olarak idealize edilen bir şiddet kavramı ile yüzleşiyoruz. Dünya genelinde militarist ve toplumsal narsizme varan politikalar, medya ve benzeri görsel iletişim araçlarında idealize edilen şiddet figürleri, okullarda çeteleşmeler, aile içi şiddet ve daha bir çok toplumsal alanda kullanılan şiddet dili. Bu çalışma, tüm bu olumsuz koşullarda beyin gelişimini tamamlamaya çalışan çocukların, şiddet ve şiddet içerikli uyaranlar karşısındaki olumsuz gelişimini değerlendirmeyi amaçlarken aynı zamanda toplumsal ve bireysel şiddetin diğer bir kurbanı olan kadınların beyin yapılarının örtülü ve sistematik şiddet karşısındaki değişim sürecini de ele almayı amaçlamaktadır. Çalışma kapsamında şiddetin tanımı yapılarak, kadınların ve çocukların şiddet ve şiddet içerikli uyaranlara bağlı olarak beyin gelişimlerindeki olumsuz etkiler üzerinde durulacaktır. Bu alanda yapılmış araştırmalar ve değerlendirmeler çalışmanın ana eksenini oluştururken, bunun yanı sıra bir zamanlar şiddetin mağduru olan bireylerin şiddet uygulama noktasındaki eğilimleri de nörolojik olarak değerlendirilerek şiddetin toplumsal döngüsünün altı çizilecektir.
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Tybout, Alice M. "Uber China." Kellogg School of Management Cases, October 31, 2017, 1–5. http://dx.doi.org/10.1108/case.kellogg.2021.000057.
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Uber China is a strategy pricing case that examines the role of customer acquisition tactics and brand positioning in entering the tantalizingly large Chinese market. The case adopts the perspective of an outside observer looking at Uber's efforts to compete in China from its entry in 2013 to its exit through its acquisition by Didi Chuxing, the highly dominant industry leader in China's ride-sharing market. After laying out the market opportunity, consumer and competitive landscape, and the various acquisition-related moves of Uber and the other major players, the case asks students to conduct a postmortem on Uber's failure in China. Specifically, they must consider what drew Uber to the opportunity in China and what it might have done differently in terms of positioning and customer acquisition to compete more effectively. First and foremost a pricing-related discussion, the case illustrates the relationship between pricing and acquisition tactics and brand positioning and the use of both in market entry and penetration.
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Wei, Yiqing, Zhuoya Yu, Lili Wang, Xiaojing Li, Na Li, Qinru Bai, Yuhang Wang, et al. "Structural bases of inhibitory mechanism of CaV1.2 channel inhibitors." Nature Communications 15, no. 1 (March 30, 2024). http://dx.doi.org/10.1038/s41467-024-47116-8.
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AbstractThe voltage-gated calcium channel CaV1.2 is essential for cardiac and vessel smooth muscle contractility and brain function. Accumulating evidence demonstrates that malfunctions of CaV1.2 are involved in brain and heart diseases. Pharmacological inhibition of CaV1.2 is therefore of therapeutic value. Here, we report cryo-EM structures of CaV1.2 in the absence or presence of the antirheumatic drug tetrandrine or antihypertensive drug benidipine. Tetrandrine acts as a pore blocker in a pocket composed of S6II, S6III, and S6IV helices and forms extensive hydrophobic interactions with CaV1.2. Our structure elucidates that benidipine is located in the DIII-DIV fenestration site. Its hydrophobic sidechain, phenylpiperidine, is positioned at the exterior of the pore domain and cradled within a hydrophobic pocket formed by S5DIII, S6DIII, and S6DIV helices, providing additional interactions to exert inhibitory effects on both L-type and T-type voltage gated calcium channels. These findings provide the structural foundation for the rational design and optimization of therapeutic inhibitors of voltage-gated calcium channels.
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Kodalak, Oğuzhan, and Emine Nihan Cici Karaboğa. "İşveren Markasının Dünü Bugünü: R Programı ile Bibliyometrik Analiz (The Past and Present of the Employer Brand: Bibliometric Analysis with the R Program)." Journal of Business Research - Turk, September 28, 2022. http://dx.doi.org/10.20491/isarder.2022.1483.
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Amaç –Bu çalışmanın amacı işveren markası kavramına dair yapılmışçalışmaların bibliyometrik özelliklerinin belirlenmesi ile kavramınliteratürdeki gelişimini değerlendirmektir.İşveren markası kavramının bibliyometrik analizini içeren bu çalışmada, kavramın literatürdeki yeri, gelişim süreçleri ve kavramdaki boşlukları belirlenerek gelecek çalışmalara yol göstermesi amaçlanmaktadır.Yöntem –İşveren markası kavramına ilişkin çalışmalar Scopus veritabanında taranmış ve R programlama dili R Studio editörüne entegre Biblioshiny ara yüzü ile analiz edilmiştir. Scopus veri tabanında işveren markası ile ilişkili kavramlar tarandıktan sonra elde edilen veriler İngilizce, Sosyal Bilimler alanında yazılmış olan makaleler gibi kısıtlar ile yeniden sınırlandırılmıştır. Bu kısıtlar sonrasında kavrama dair ilk makalenin 2004 yılında yayınlandığı ve 2004-2021 yılları arasında 160 dergi de yayınlanmış 256 makale olduğu tespit edilmiştir.Bu makalelere ilişkin BibTex dosyası ile elde edilen veriler yazar, kaynak, atıf ve ortak kelime bağlamında bibliyometrik haritalama analizleri ile görselleştirilmiş ve bu haritalar yorumlanmıştır.Bulgular –Yapılan analizler sonucunda işveren markası kavramına ilişkin en fazla yayın yapan derginin Sustainability (Switzerland) iken, en fazla atıf alan dergi ise “Career Development International” olarak tespit edilmiştir. İşveren markasına dair en fazla yayın yapan yazar Gordhan Kumar Saini iken, en çok atıf alan yazar 149 atıf ile Filip Lievens’dir. Tartışma –Kavram yoğun olarak gelecek, yönetim, insan kaynakları gibi kavramlarla eşleştirilmiştir. İşveren markası, bu üst başlıklar altında daha özelleştirildiğinde özellikle marka değeri, çalışan mutluluğuve kurum kimliği gibi kavramlarla ilişkisinin de incelenmesi yerinde olacaktır. Bu çalışmada kavramın Scopus veri tabanında makale bazında incelenmiş olduğu göz önünde bulundurulduğunda, farklı veri tabanlarında özellikle de Türkçe yazındaki yerine dair bir bibliyometrik çalışmanın yapılması kavramın literatürdeki yerini anlamak ve farklı çalışmalara yön vermek için önerilmektedir.
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Bocci, Giovanni, Tudor I. Oprea, and Leslie Z. Benet. "State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References." AAPS Journal 24, no. 2 (February 23, 2022). http://dx.doi.org/10.1208/s12248-022-00687-0.
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AbstractThe Biopharmaceutics Drug Disposition Classification system (BDDCS) is a four-class approach based on water solubility and extent of metabolism/permeability rate. Based on the BDDCS class to which a drug is assigned, it is possible to predict the role of metabolic enzymes and transporters on the drug disposition of a new molecular entity (NME) prior to its administration to animals or humans. Here, we report a total of 1475 drugs and active metabolites to which the BDDCS is applied. Of these, 379 are new entries, and 1096 are revisions of former classification studies with the addition of references for the approved maximum dose strength, extent of the systemically available drug excreted unchanged in the urine, and lowest solubility over the pH range 1.0–6.8 when such information is available in the literature. We detail revised class assignments of previously misclassified drugs and the literature analyses to classify new drugs. We review the process of solubility assessment for NMEs prior to drug dosing in humans and approved dose classification, as well as the comparison of Biopharmaceutics Classification System (BCS) versus BDDCS assignment. We detail the uses of BDDCS in predicting, prior to dosing animals or humans, disposition characteristics, potential brain penetration, food effect, and drug-induced liver injury (DILI) potential. This work provides an update on the current status of the BDDCS and its uses in the drug development process. Graphical abstract
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Odimayo, Simisola, Chollette C. Olisah, and Khadija Mohammed. "Structure focused neurodegeneration convolutional neural network for modelling and classification of Alzheimer’s disease." Scientific Reports 14, no. 1 (July 3, 2024). http://dx.doi.org/10.1038/s41598-024-60611-8.
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AbstractAlzheimer’s disease (AD), the predominant form of dementia, is a growing global challenge, emphasizing the urgent need for accurate and early diagnosis. Current clinical diagnoses rely on radiologist expert interpretation, which is prone to human error. Deep learning has thus far shown promise for early AD diagnosis. However, existing methods often overlook focal structural atrophy critical for enhanced understanding of the cerebral cortex neurodegeneration. This paper proposes a deep learning framework that includes a novel structure-focused neurodegeneration CNN architecture named SNeurodCNN and an image brightness enhancement preprocessor using gamma correction. The SNeurodCNN architecture takes as input the focal structural atrophy features resulting from segmentation of brain structures captured through magnetic resonance imaging (MRI). As a result, the architecture considers only necessary CNN components, which comprises of two downsampling convolutional blocks and two fully connected layers, for achieving the desired classification task, and utilises regularisation techniques to regularise learnable parameters. Leveraging mid-sagittal and para-sagittal brain image viewpoints from the Alzheimer’s disease neuroimaging initiative (ADNI) dataset, our framework demonstrated exceptional performance. The para-sagittal viewpoint achieved 97.8% accuracy, 97.0% specificity, and 98.5% sensitivity, while the mid-sagittal viewpoint offered deeper insights with 98.1% accuracy, 97.2% specificity, and 99.0% sensitivity. Model analysis revealed the ability of SNeurodCNN to capture the structural dynamics of mild cognitive impairment (MCI) and AD in the frontal lobe, occipital lobe, cerebellum, temporal, and parietal lobe, suggesting its potential as a brain structural change digi-biomarker for early AD diagnosis. This work can be reproduced using code we made available on GitHub.
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Jansson Mörk, Marie, Nadja Karamehmedovic, Anette Hansen, Joanna Nederby Öhd, Mats Lindblad, Emma Östlund, Moa Rehn, and Cecilia Jernberg. "Outbreak of Salmonella Newport linked to imported frozen cooked crayfish in dill brine, Sweden, July to November 2019." Eurosurveillance 27, no. 22 (June 2, 2022). http://dx.doi.org/10.2807/1560-7917.es.2022.27.22.2100918.
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In autumn 2019, the Public Health Agency of Sweden identified a cluster of Salmonella Newport cases by whole genome sequencing (WGS). Cases’ distribution in place and time indicated a nation-wide ongoing outbreak. An investigation was initiated to identify the source and prevent further cases. We conducted a case–case study based on notified salmonellosis cases and a Salmonella trawling questionnaire, comparing 20 outbreak cases and 139 control cases. Food exposures were compared by adjusted odds ratios (aOR) with 95% confidence interval (CI) using logistic regression. Implicated foods were sampled. Outbreak cases were more likely to have consumed crayfish (aOR = 26; 95% CI: 6.3–105). One specific brand of imported frozen, pre-cooked whole crayfish in dill brine was identified as the source. Salmonella Newport was later detected in different batches from retail and in one sample from border control. Isolates from food samples clustered with the human outbreak strain by WGS. Although the retailer made a complete recall, two more cases were identified long afterwards. This investigation demonstrated the successful use of a case–case study and targeted microbiological testing to identify the source. The immediate action taken by the retailer was important to confirm the source and stop the outbreak.
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Daini, Roberta. "The Lack of Self-Consciousness in Right Brain-Damaged Patients Can Be due to a Disconnection From the Left Interpreter: The DiLeI Theory." Frontiers in Psychology 10 (February 28, 2019). http://dx.doi.org/10.3389/fpsyg.2019.00349.
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Mendieta Badimon, L. G., E. Guasch, D. Weir, D. Aristizabal, L. Llull, L. Mont, A. Bayes De Luna, and M. Sitges. "P3770Interatrial block: a prognostic factor for atrial fibrillation in cryptogenic stroke patients." European Heart Journal 40, Supplement_1 (October 1, 2019). http://dx.doi.org/10.1093/eurheartj/ehz745.0620.
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Abstract Background Atrial fibrillation (AF) is a well-known risk factor for ischemic stroke. Interatrial block (IAB), resulting from a conduction delay in Bachmann's bundle, is an electrical abnormality that, especially in its advanced (A-IAB) form, has been associated with atrial fibrotic cardiopathy and remodeling, sharing a common pathologic substrate with AF. Therefore, IAB has been proposed as a marker of atrial electromechanical dysfunction that may predispose to the development of AF. We hypothesized that IAB could be a marker of AF in patients with cryptogenic stroke (CS). Methods We retrospectively screened a cohort of CS patients with no prior history of AF, and collected their demographic, cardiovascular risk factors and other co-morbidities, stroke severity and resultant functional disability (NIHSS and mRS scales), CHA2DS2-VASc score, baseline 12-lead ECG, transthoracic echocardiogram, and neuroimaging studies on admission. All patients underwent continuous ECG monitoring for at least 48h. Forty-eight (64%) patients underwent additional out-patient 24h Holter monitoring following hospital discharge. P-wave (PW) analysis of baseline ECG classified patients into three groups: normal p-wave duration (N, PW <120 ms), partial IAB (P-IAB, PW ≥120 ms) and advanced IAB (A-IAB, PW ≥120 ms and biphasic morphology in leads DII, DIII and aVF). AF episodes (defined as irregular supraventricular arrhythmias without detectable PWs lasting >30 s), frequent premature atrial contractions (PACs) (>1%) and atrial tachyarrhythmia episodes (runs of >3 consecutive PACs) were detected on 24h Holter readings. Ischemic brain lesions were classified as cortical, subcortical or lacunar in relation to their localization and maximal diameter. Results Out of the 80 consecutive CS patients identified, 5 were excluded due to poor quality ECG readings. A high prevalence of both P-IAB (n=30, 40%) and A-IAB (n=23, 30.7%) was found in the final analysis with 75 CS patients. No differences were found between demographics, cardiovascular risk factors and co-morbidities, NIHSS, mRS and CHA2DS2-VASc scores, left atrial size and left ventricular ejection fraction among the 3 ECG categories. Cortical ischemic brain lesions were more frequent in patients in the IAB groups than in the N ECG group. After a mean follow-up of 522 days, AF was clinically diagnosed in 13 patients (17%), with an increasing risk in accordance to the severity of the IAB (p<0.05) (Figure 1A). 24h Holter readings showed greater frequency of PACs and atrial tachyarrhythmia episodes in patients with IAB (p<0.05) (Figure 1B). Figure 1 Conclusions In CS, IAB is associated with a greater risk to develop AF and its presence identifies a subgroup of patients with probable atrial fibrotic cardiopathy that could potentially benefit from early oral anticoagulation in secondary prevention.
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Couto Pereira, S., B. Valente Silva, P. Silverio Antonio, J. Brito, P. Alves Da Silva, C. Simoes De Oliveira, A. Beatriz Garcia, et al. "Electrocardiography: an usefull tool for prediction of the diagnosis and severity of pulmonary embolism." EP Europace 24, Supplement_1 (May 18, 2022). http://dx.doi.org/10.1093/europace/euac053.002.
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Abstract Funding Acknowledgements Type of funding sources: None. Introduction Pulmonary embolism (PE) is associated with morbidity and mortality. Immediate recognition of this condition is critical to commencement of early and appropriate therapy which could be lifesaving. Particularly in patients with suspected PE in which computed tomography pulmonary angiography (CTPA) is not promptly available or is contra-indicated, an electrocardiographic (ECG) score could serve as a ubiquitously available test to raise suspicion of PE. This study aimed to evaluate the diagnostic value of an ECG score for PE diagnosis. Methods Retrospective study of consecutive patients who performed CTPA in Emergency Department due to PE suspicion. All ECG were scored according to the previous published Daniel’s ECG score, by an investigator blinded for the CTPA result. Results The most common ECG findings in patients with PE were incomplete right-brand bock (48%), T wave inversion in DIII (48%), sinus tachycardia (41%) and Q wave in DII (31%). The S1Q3T3 sign was documented in 20% of patients. The ECG score was significantly higher in patients with PE compared to those without PE (5.06 vs 3.70, p=0.005). ECG score showed moderate accuracy to detect PE (AUC: 0.60; 95%CI: 0.53-0.67; p=0.004), but it is of a particular value because of very high specificity: an ECG score > 12 identified PE with a specificity of 96% (95% CI 91.93 – 98.38). The ECG score significantly increased the diagnostic accuracy of the diagnostic algorithm based on pretest clinical probability evaluated by Wells score combined with D-Dimer measurement (Wells & DD). In comparison to patients in which clinical pretest probability combined with D-dimer measurement considers PE excluded (Wells & ECG -), PE was 6.3 times more frequent in patients with Wells & DD +/ECG- (95% 2.7- 14.5) and 14.6 times more prevalent in the ones with Wells & DD +/ECG+ (95%CI: 4.1-51.3; p<0.001) – Figure 1. Conclusion In patients with clininal suspition of PE, na ECG score (Daniel’s score) >12 predicts PE with 96% specificity and could be used to increase the suspicion and define therapeutic strategy in patients in whom CTPA could not be immediately performed or is contra-indicated.
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Muzayyaroh, M., and S. Suyati. "HUBUNGAN KADAR Hb (HAEMOGLOBIN) DENGAN PRESTASI BELAJAR PADA MAHASISWI PRODI D-III KEBIDANAN FIK UNIPDU JOMBANG." Jurnal Kesehatan Kusuma Husada, July 23, 2018, 220–25. http://dx.doi.org/10.34035/jk.v9i2.283.
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ABSTRAK Penurunan kadar hemoglobin dalam darah akan mengakibatkan berkurangnya suplai oksigen pada organ-organ tubuh, terutama organ – organ vital seperti otak, dan jantung . Jika kadar Hb rendah berarti dapat dipastikan bahwa seseorang akan mengalami anemia. Anemia dapat mengakibatkan berkurangnya daya pikir dan konsentrasi seseorang, menurunnya prestasi belajar pada remaja sekolah karena mengalami kesulitan berkonsentrasi. Dampak negatif lain yang ditimbulkan oleh anemia adalah daya tahan tubuh berkurang sehingga menyebabkan tubuh mudah terserang penyakit, serta kemampuan kinerja intelektual juga menurun. Untuk mengetahui hubungan antara kadar Hb dengan prestasi belajar mahasiswi Prodi D III Kebidanan FIK Unipdu Jombang. Desain yang digunakan dalam penelitian ini adalah analitik dengan pendekatan Cross Sectional, populasi dalam penelitian ini adalah mahasiswi Prodi D-III Kebidanan FIK Unipdu Jombang, pengambilan sampel dilakukan dengan Total Sampling yaitu sebanyak 40 responden. Untuk mengetahui kadar Hb (Haemoglobin) dilakukan pemeriksaan Hb langsung kepada responden dan Prestasi Belajar melihat Kartu Hasil Belajar responden (KHS), untuk mengetahui hubungan dua variabel menggunakan uji statistik Spearman Corelation dengan bantuan SPSS 13 dengan taraf kemaknaan m = 0,05. Berdasarkan hasil penelitian ini maka dapat bahwa semakin tinggi kadar haemoglobin maka semakin baik prestasi belajarnya. Asupan gizi yang baik dan tidak mengalami anemia maka dapat mempengaruhi prestasi belajar. Ada hubungan antara Kadar Haemoglobin dengan Prestasi Belajar di Prodi D-III Kebidanan FIK Unipdu Jombang. Kata Kunci: Haemoglobin, Prestasi Belajar ABSTRACT Decreased levels of hemoglobin in the blood will lead to reduced supply of oxygen in the organs of the body, especially vital organs such as brain, and heart. If low Hb levels mean it is certain that a person will develop anemia. Anemia can lead to decreased thinking power and concentration, decreased learning achievement in school adolescents because of difficulty concentrating. Another negative impact caused by anemia is reduced immune system that causes the body susceptible to disease, as well as the ability of intellectual performance is also decreased. To know the relationship between Hb level with student achievement of Prodi D III Midwifery FIK Unipdu Jombang. The design used in this research is analytical with Cross Sectional approach, population in this research is student of Prodi D-III Midwifery FIK Unipdu Jombang, sampling is done with total sampling that is counted 40 respondents. To find out the level of Hb (Haemoglobin) done direct examination of Hb to the respondent and Learning Achievement see Respondent Study Results Card (KHS), to know the relationship of two variables using Spearman Corelation statistical test with SPSS 13 with significance μ = 0,05. Based on the results of this study it can be that the higher the hemoglobin level the better the learning achievement. A good nutritional intake and no anemia can affect learning achievement. There is a correlation between Haemoglobin Level and Learning Achievement in DIKI D-III Prodi FIK Unipdu Jombang. Keyword ; Haemoglobin, Learning Achievement