Dissertations / Theses on the topic 'Hypothermia'
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Léon, Karelle. "L'hypothermie modérée induite chez un modèle murin : une solution thérapeutique au sepsis ?" Thesis, Brest, 2012. http://www.theses.fr/2012BRES0030.
Full textDespite numerous studies over the past twenty years, sepsis, a pathologic state related to a systemicinflammatory response following infection, remains the main cause of death in intensive care units.Among the therapeutic approaches proposed, hypothermia is a good candidate. Indeed, mild inducedhypothermia increased the survival duration of septic rats. This work aimed to provide elements tounderstand and identify the mechanisms responsible for this beneficial effect. Consequently, variousfunctions commonly affected during sepsis (inflammation, oxidative stress, renal failure, oxygen bloodcapacity and acid-base balance) were studied on septic rats maintained in mild induced hypothermia(34°C). The results showed that mild hypothermia significantly slows the cytokine proinflammatoryproduction and tends to exert a decrease in the radical systemic production of septic rats. Theappearance of metabolic acidosis and renal failure are also delayed. Finally, while in normothermiasepsis led to a decrease in the cooperativity and oxygen haemoglobin affinity, synonymous of anadaptation when faced with potential deleterious changes, in mild hypothermia, these parameters arenot modified. These results suggest that by reducing the development of sepsis, mild inducedhypothermia increases the survival duration of septic rats. Thus, hypothermia may be an option fortreating patients with severe sepsis by stalling inflammation and controlling aggression, therebydelaying organ failure
Wladis, Andreas. "Hypothermia and trauma /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4574-8/.
Full textIslam, Shahed. "Therapeutic hypothermia in cardiovascular disease." Thesis, Anglia Ruskin University, 2017. http://arro.anglia.ac.uk/704083/.
Full textIslam, Shahed. "Therapeutic hypothermia in cardiovascular disease." Thesis, Anglia Ruskin University, 2017. https://arro.anglia.ac.uk/id/eprint/704083/1/Islam_2017.pdf.
Full textCovaciu, Lucian. "Intranasal Cooling for Cerebral Hypothermia Treatment." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134278.
Full textFiniels, Amber. "Therapeutic hypothermia to prevent neurological deficits." Honors in the Major Thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1404.
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Bashir, Shazma. "Mechanism of Paracetamol (acetaminophen) induced hypothermia." Thesis, University of East London, 2018. http://roar.uel.ac.uk/7308/.
Full textHutin, Alice. "Etude expérimentale de l’arrêt cardiaque réfractaire chez le porc : nouvelles approches thérapeutiques." Thesis, Paris Est, 2017. http://www.theses.fr/2017PESC0030/document.
Full textOut of hospital cardiac arrest (CA) is a major public health issue, despite the implementation of a “chain of survival”. Resuscitation durations are often extended with irreversible organ damage and poor outcome. Frequently, conventional care does not allow the return of spontaneous circulation, leading to a refractory CA, with the need for advanced therapeutic care. The general objective of this work was to evaluate new therapeutic strategies in the management of refractory cardiac arrest. We studied two experimental strategies in swine, involving ultrafast cooling with total liquid ventilation or extracorporeal cardiopulmonary resuscitation in a CA of ischemic origin.As a first step, we evaluated the feasibility of ultra-fast therapeutic hypothermia using total liquid ventilation (TLV) in swine. This approach involves perfluorocarbon instillation in the lungs to induce ultra-fast cooling. The lungs are thus used as a heat exchanger, while maintaining normal gas exchanges. In previous studies, the laboratory has shown that TLV could reduce blood temperature to 32°C in less than 10 minutes in rabbits. The objective of this study was to determine if TLV could lead to ultra-fast cooling in swine. We first studied the cooling capacity of hypothermic TLV in beating heart pigs, and then during ventricular fibrillation with prolonged chest compressions. In physiological conditions, in “beating heart” animals, the target temperature of 34°C was obtained in less than 10 min in the whole body. In prolonged resuscitation of refractory CA, whole body cooling was also rapidly obtained, within less than 25 min. TLV did not alter the hemodynamic effect of cardiac compressions, suggesting further use of this “intra-resuscitation” cooling in order to increase chances of defibrillation or for organ preservation for the purpose of organ donation.As a second step, we addressed the subject of ischemic refractory CA treated by extracorporeal cardiopulmonary resuscitation (ECPR). Our objective was to evaluate the importance of early coronary reperfusion in this situation, i.e., it’s impact on hemodynamic status and chances of defibrillation. After anesthesia and surgical preparation, animals were submitted to a coronaryocclusion followed by 5 min of CA by ventricular fibrillation. Conventional cardiopulmonary resuscitation was then initiated and followed by extracorporeal cardiopulmonary resuscitation.We compared the effect of early versus late reperfusion, i.e., reperfusion after 20 or 120 min of ECPR. Early reperfusion significantly increased chances of return to spontaneous circulation with limited shock status, increased cerebral perfusion and decreased infarct size. This confirms the need for early treatment of acute coronary syndrome if cardiac cause of CA is suspected, even in the situation of ECPR.In conclusion, we have shown that TLV could provide ultra-fast whole body cooling, both in beating heart swine and during prolonged resuscitation. Secondly, early reperfusion in refractory ischemic CA treated by ECPR globally increases chances of return to spontaneous circulation and improves hemodynamic status
Klock, Julia Cathy. "Rapid whole-body hypothermia : analysis and modeling /." View online ; access limited to URI, 2007. http://0-digitalcommons.uri.edu.helin.uri.edu/dissertations/AAI3276989.
Full textCollins, Michael. "Dysphagia in Encephalopathic Neonates Treated with Hypothermia." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/281173.
Full textObjective: The purpose of this study is to determine the rate of dysphagia in neonates treated with targeted body temperature reduction as compared to neonates who have not been exposed to hypothermia. Methods: We performed a retrospective study of encephalopathic neonates who were treated with hypothermia and who underwent a modified barium swallow (MBS). For comparison, a group of neonates who had been evaluated with MBS but did not receive hypothermic therapy was identified. This group consisted of non-encephalopathic patients. MBS results were qualified as either normal or abnormal. Results: There was no statistically significant difference in the percentage of abnormal MBS results between the hypothermic and control groups (Fisher’s exact; P = 0.78). The odds ratio for abnormal MBS results in the hypothermia group relative to the control group was 1.2, with 95% confidence interval of 0.42 to 3.8. Significance: These data indicate that hypothermia does not seem to increase short term risk of dysphagia compared to the control group. There is no apparent association between hypothermia and dysphagia. This supports previous findings that hypothermia is a safe treatment for neural injuries in NICU patients.
Lundgren, Peter. "Protection and treatment of hypothermia in prehospital trauma care : with emphasis on active warming." Doctoral thesis, Umeå universitet, Kirurgi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54304.
Full textBelke, Darrell David. "Hypothermia and energy substrate metabolism in the heart." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21548.pdf.
Full textRabinowitz, Patricia. "Malignant Hypothermia Preparedness for Labor and Delivery Nurses." Otterbein University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=otbn1596205650329567.
Full textVan, Someren Robert Niall Melville. "An investigation into the cause of insidious hypothermia occurring during immersion in lukewarm water, and of the mental consequences of hypothermia." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/27018.
Full textHorwitz, Elizabeth Rachel. "The role of calcium in temperature resistance of hibernator cells." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334127.
Full textZheng, Fashan. "Baroreceptors and cardiopulmonary reflexes : afferent pathways and the influence of cold." Thesis, University of Aberdeen, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262348.
Full textPakanen, L. (Lasse). "Thrombomodulin and catecholamines as post-mortem indicators of hypothermia." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526208251.
Full textTiivistelmä Paleltumiskuolemat ovat oikeuslääketieteellisesti haastavia, koska vainajaan ei jää paleltumiseen viittaavia yksiselitteisiä löydöksiä. Virtsan katekoliamiinien, adrenaliinin ja noradrenaliinin, pitoisuudet kasvavat stressitilanteissa kuten kylmäaltistuksessa. Korkeita pitoisuuksia on pidetty paleltumiseen viittaavana tekijänä. Paremmalle paleltumista osoittavalle merkkiaineelle on kuitenkin selkeä tarve. Eräs mahdollinen merkkiaine voisi olla trombomoduliini (TM), joka on endoteelisolujen tuottama proteiini. Sen plasmapitoisuuden on aiemmin osoitettu nousevan alilämpöisyystilassa. TM- ja katekoliamiinitasoja tutkittiin lyhyessä kylmäaltistuksessa (koehenkilöt, n = 7) sekä lievässä ja vaikeassa alilämpöisyystilassa joko lämmityksen jälkeen tai ilman lämmitystä (rotat, n = 96). Lisäksi verrattiin paleltumisen, sydän- ja verisuonitautien, vammojen sekä muiden syiden aiheuttamia kuolemia (ruumiinavausaineisto, n = 552). Sydänlihaksen trombomoduliini-transkriptin taso oli kohonnut vaikeasti alilämpöisillä rotilla, mutta se oli matalampi paleltumiskuolemissa kuin muissa kuolemissa. Veren TM-taso oli hetkellisesti alentunut vaikeassa alilämpöisyystilassa. Sydänlihaksen ja virtsan TM-proteiinipitoisuudet olivat matalampia paleltumiskuolemissa kuin muissa kuolemansyissä. TM- ja katekoliamiinitasot korreloivat merkittävästi veressä ja virtsassa sekä koehenkilöillä ja -eläimillä että vainaja-aineistossa. Vaikeasti alilämpöisillä rotilla todettiin käänteinen suhde plasman adrenaliinipitoisuuden ja sydänlihaksen trombomoduliini-transkriptitason välillä. Tulosten perusteella alilämpöisyystila muuttaa TM:n ekspressiota ja erittymistä, mikä voi liittyä katekoliamiinien vaikutuksiin. Kuolemanjälkeisten TM- ja katekoliamiinitasojen määritys tuo lisänäyttöä kuolemaa edeltäneestä kylmävaikutuksesta epäiltäessä paleltumiskuolemaa. Lisätutkimuksia tarvitaan TM:n solutason säätelymekanismien selvittämiseksi
英志麟 and Chee-lun Aaron Ying. "Hypothermia and platelet dysfunction: monitoring and effects of desmopressin." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40722168.
Full textHarper, Christopher Mark. "Clinical approaches to the prevention of inadvertent perioperative hypothermia." Thesis, University of Portsmouth, 2016. https://researchportal.port.ac.uk/portal/en/theses/clinical-approaches-to-the-prevention-of-inadvertent-perioperative-hypothermia(9b5a8d95-f7d3-4271-8444-acd0b7845fa0).html.
Full textYing, Chee-lun Aaron. "Hypothermia and platelet dysfunction monitoring and effects of desmopressin /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40722168.
Full textKohlhauer, Matthias Quentin. "Étude expérimentale de l'hypothermie induite par ventilation liquide totale au décours d'un arrêt cardiaque choquable et non choquable." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0081.
Full textCardiac arrest is a major public health issue, concerning 40000 patients every year in France. Among the successfully resuscitated patients, most of them develop severe neurological, cardiac and multivisceral dysfunctions, leading to an aggravation of the prognosis. One of the strategies that could improve this prognosis is mild therapeutic hypothermia at 32-34 degres°C during 24 hours. However, recent clinical studies demonstrated limited benefits in patients, as compared to experimental studies. One of the explanations could be the relatively prolonged delay for hypothermia achievement in humans as compared to laboratory animals. In order to induce similar cooling rate in humans than animals, the laboratory is investigating a strategy for ultra-fast cooling through total liquid ventilation (TLV). This strategy consists in lungs ventilation with cold perfluorocarbons, which could use the lungs as a heat-exchanger while maintaining normal gas exchanges.The general goal of the present study was to experimentally investigate the consequences of ultra-fast cooling in different situations of cardiac arrest in rabbits. This could lead to determine the most relevant clinical setting for a further clinical translation of TLV in patients.Accordingly, we initially studied the effect of conventional hypothermia through fluid administration during cardiac massage in a rabbit model of shockable cardiac arrest. Such conventional hypothermia did not provide any benefit. Then, we investigated the effect of cooling induced by TLV in rabbits submitted to cardiac arrest from different causes. After ischemic cardiac arrest from shockable rhythm, TLV was associated with potent neuro- and cardioprotective effects, along with strong survival improvement and multivisceral dysfunction limitations. After cardiac arrest from respiratory and non-shockable cause, TLV provided potent neurological benefit. This was exerted very early after resuscitation through the reduction of the blood-brain barrier permeability, reactive oxygen species production, acute cerebral hyperhaemia or inflammatory response.In conclusion, TLV-induced cooling provides potent neurological and systemic benefits after experimental cardiac arrest from different causes in rabbits. These works describe the existence of a therapeutic window for hypothermia, very early after cardiac arrest. This strengthens the relevance of TLV for cooling induction. For a further clinical translation, non-shockable cardiac arrest could be a relevant clinical situation, considering the very poor prognosis
Silva, Aline Batista da. "Hipotermia inadvertida perioperatória em pacientes cirúrgicos no Brasil: como estamos prevenindo?" Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-27042018-145724/.
Full textIntroduction: Perioperative inadvertent hypothermia is a frequent event and affects about 70% of surgical patients, leading to important complications, such as cardiovascular alterations, surgical site infection, patient discomfort, hospitalization time, and others. Because it offers innumerable risks to the surgical patient, the occurrence of perioperative unintentional hypothermia has gained space in the current literature. Perioperative temperature maintenance has been suggested in the literature with the implementation of passive and active heating methods such as increased operating room temperature, use of cotton blanket, use of thermal blanket, use of forced air devices, infusion of fluids heated, among others. However, there is no published study in Brazil to investigate the performance of the teams that work in the surgical block, and to prevent perioperative hypothermia in hospitals. Objectives: To verify how temperature monitoring and the prevention of perioperative inadvertent hypothermia occur in surgical patients hospitalized in Brazilian hospitals. Material and method: A cross-sectional study was carried out in the city of São Paulo through a questionnaire filled out by nurses participating in the 12th Brazilian Congress of Nursing in Surgical Center, Anesthetic Recovery and Material and Sterilization Center. The data were analyzed descriptively and demonstrated in the tables. Results: Temperature monitoring in the perioperative period has not been systematically performed by all surgical center professionals, but the practice of this practice was reported by 92.4% in the preoperative period, 83.8% in the intraoperative period and 94, 9% in the postoperative period. The prevention of inadvertent perioperative hypothermia is a practice practiced by the vast majority of participants (96%), with predominance in passive methods of maintaining normothermia in the preoperative periods (51%) and association of passive and active methods in the post- 64.6%) and intraoperative (45.5%) maintenance of normothermia in the surgical patient. The main professionals involved in temperature monitoring and the prevention of inadvertent perioperative hypothermia are the nursing team and anesthesiologists. Although a large number of professionals do not report the occurrence rate of inadvertent perioperative hypothermia, it is noted that for most of the respondents the occurrence of this event is low. Conclusion: the practice of practices for the maintenance of operative normothermia is reality for the nursing team. Temperature monitoring is not yet performed consistently throughout the perioperative period. The prevention of inadvertent hypothermia in the perioperative period is a very frequent practice among surgical procedures.
Barrett, Robert Daniel. "Therapeutic hypothermia and its effects on the preterm fetal sheep." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/7200.
Full textZimmerman, Angela D. "Nursing interventions in the care of patients undergoing induced hypothermia." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/531.
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Phillips, Kristin. "The effects of hypothermia on status epilepticus-induced acquired epilepsy." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2544.
Full textJohann, Kornelia [Verfasser]. "Mechanisms of thyroid hormone induced hypothermia in mice / Kornelia Johann." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2020. http://d-nb.info/1206388323/34.
Full textDarbera, Lys. "Etude de la ventilation liquide totale hypothermisante sur le syndrome post-arrêt cardiaque chez le lapin." Thesis, Paris Est, 2013. http://www.theses.fr/2013PEST0105/document.
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Vanhuyse, Fabrice. "Évaluation des bénéfices thérapeutiques apportés par l’hypothermie dans le traitement du choc cardiogénique sous ECMO chez l’animal." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0320/document.
Full textCardiogenic shock is still considered as a severe medical condition. Despite much progress in the treatment of the cardiogenic shock, this disease is still associated with a high mortality. An important advance in the treatment of the cardiogenic shock is the use of ECMO. However, despite the restoration of a proper circulatory flow, we are still facing significant mortality in these patients. The first part of this manuscript is a reminder of the main concepts of the cardiogenic shock and ECMO and the concept of hypothermia. In the second part, we report the results of our experimental research who highlighted a beneficial effect of hypothermia in cardiac function and vascular reactivity in animals in cardiogenic shock treated by ECMO. In the third part we discuss our results and we try to rapport physiological explications of our results
England, Adrian James. "The effect of moderate hypothermia on neuromuscular transmission and neuromuscular blockade." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338687.
Full textLarsson, Ing-Marie. "Post-Cardiac Arrest Care : Therapeutic Hypothermia, Patient Outcomes and Relatives’ Experiences." Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229758.
Full textSabharwal, Rasnapreet. "The integrative physiological responses to acute and chronic hypothermia in rats." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411870.
Full textBlowers, Stephen John. "Modelling brain temperatures in healthy patients and those with induced hypothermia." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31248.
Full textOsama, Mohammad. "Function of Vascular Endothelial Cells in Aging and Hypothermia: Clinical Implications." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534939514503588.
Full textNordmark, Johanna. "Aspects of induced hypothermia following cardiopulmonary resuscitation cerebral and cardiovascular effects /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9562.
Full textRomsi, P. (Pekka). "Adjuncts to improve neurological outcome following hypothermic circulatory arrest:an experimental study using a chronic porcine model." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514269217.
Full textRoy, Matthew S. "Acute effects of facial cooling on arterial stiffness and wave reflection." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 56 p, 2007. http://proquest.umi.com/pqdweb?did=1397914231&sid=1&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Full textBäck, Andreas, and Robin Augustsson. "Oönskad perioperativ hypotermi : En kvalitativ studie om anestesisjuksköterskans upplevelse." Thesis, Högskolan i Borås, Akademin för vård, arbetsliv och välfärd, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-309.
Full textCheng, Tan-ning, and 鄭丹寧. "An evidence-based guideline on preoperative warming of patients undergo general anesthesia to reduce postoperative hypothermia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193046.
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Winterås, Elisabeth, and Rosth Kerstin Lindberg. "Ofrivillig hypotermi under den perioperativa vården : Inadvertent hypothermia in the perioperativ care." Thesis, Högskolan Dalarna, Omvårdnad, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:du-5554.
Full textBrändström, Helge. "Accidental hypothermia and local cold injury : physiological and epidemiological studies on risk." Doctoral thesis, Umeå universitet, Anestesiologi och intensivvård, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-55602.
Full textAl-Shargabi, Tareq. "Spectral Analysis of Nonstationary Heart Rate of Neonates Receiving Therapeutic Hypothermia Treatment." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3273.
Full textMcGlynn, Karen Patricia. "The effect of hypothermia and rewarming on cardiac electrophysiology and mechanical function." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8169/.
Full textHolmberg, Petra, and Carolina Söderback. "Oavsiktlig hypotermi : Operationssjuksköterskans preventiva interventioner." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-34505.
Full textKwok, Ka-wai, and 郭嘉慧. "The use of warmed intravenous fluid in reducing hypothermia in patients after major surgery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44623616.
Full text邱靜雯 and Ching-man Yau. "Use of occlusive wrap to prevent hypothermia in premature infants immediately after birth." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193042.
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Scott, Chris G. "A comparison of endogenous versus exogenous heating on the subsequent development of hypothermia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58502.pdf.
Full textLoidl, César Fabián. "Asphyxia during birth biochemical and morphological study in basal ganglia : implication of hypothermia /." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=6771.
Full textKerr, Chadwick G. "Hypothermia during Olympic triathlon : influence of body heat storage during the swimming stage." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1014852.
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Iwata, S. "Brain temperature, perfusion and metabolism under thermo-neutral condition and with induced hypothermia." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1432502/.
Full textHoran, Marie. "A pilot investigation of mild hypothermia in neonates receiving extracorporeal membrane oxygenation (ECMO)." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/29533.
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