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Journal articles on the topic 'Hypotensive effect of apelin'

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Published: 19 July 2023

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1

Lee, Dennis K., Victor R. Saldivia, Tuan Nguyen, Regina Cheng, Susan R. George, and Brian F. O’Dowd. "Modification of the Terminal Residue of Apelin-13 Antagonizes Its Hypotensive Action." Endocrinology 146, no. 1 (2005): 231–36. http://dx.doi.org/10.1210/en.2004-0359.

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The apelin peptide is the endogenous ligand for the apelin G protein-coupled receptor. The distribution of the apelin peptides and receptor are widespread in the central nervous system and periphery, with reported roles in the hypothalamic-pituitary-adrenal axis, blood pressure regulation and as one of the most potent positive inotropic substances yet identified. In this report, we show that in native tissues preproapelin exists as a dimer. Dimeric preproapelin was reduced to monomers by dithiothreitol treatment, indicating disulfide linkages. To evaluate the role of the carboxyl-terminal phen

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Fernandez, Kleinberg X., Conrad Fischer, Jennie Vu, et al. "Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators." RSC Medicinal Chemistry 12, no. 8 (2021): 1402–13. http://dx.doi.org/10.1039/d1md00120e.

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Besserer-Offroy, Élie, Patrick Bérubé, Jérôme Côté та ін. "The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment". Pharmacological Research 131 (травень 2018): 7–16. http://dx.doi.org/10.1016/j.phrs.2018.02.032.

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4

Zhang, Rong, Jingyi Lu, Cheng Hu, et al. "Associations of Common Variants atAPLNand Hypertension in Chinese Subjects with and without Diabetes." Experimental Diabetes Research 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/917496.

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Background. Apelin, the endogenous ligand for the APJ receptor, has a potent hypotensive effect via a nitric oxide-dependent mechanism in vivo. The aim of the study was to investigate the association between the common variants of apelin gene (APLN) and hypertension, which was reported recently in a Chinese Han population with and without diabetes.Methods. Three single nucleotide polymorphisms (SNPs) onAPLNwere genotyped in 3156 diabetic patients and 3736 nondiabetic individuals. For non-diabetic subjects, 1779 were enrolled in stage 1 and 1757 were recruited for validation. A meta-analysis co

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Trojanowicz, Bogusz, Christof Ulrich, and Matthias Girndt. "Uremic Apelin and Leucocytic Angiotensin-Converting Enzyme 2 in CKD Patients." Toxins 12, no. 12 (2020): 742. http://dx.doi.org/10.3390/toxins12120742.

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Apelin peptides (APLN) serve as second substrates for angiotensin-converting enzyme 2 (ACE2) and, in contrast to angiotensin II (AngII), exert blood-pressure lowering and vasodilatation effects through binding to G-coupled APLN receptor (APLNR). ACE2-mediated cleavage of the APLN may reduce its vasodilatory effects, but decreased ACE2 may potentiate the hypotensive properties of APLN. The role of APLN in uremia is unclear. We investigated the correlations between serum-APLN, leucocytic APLNR, and ACE2 in 32 healthy controls (NP), 66 HD, and 24 CKD3–5 patients, and the impact of APLN peptides o

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Пальцын, А. А., and Н. Б. Свиридкина. "Apelin." Nauchno-prakticheskii zhurnal «Patogenez», no. 2 (June 28, 2021): 83–90. http://dx.doi.org/10.25557/2310-0435.2021.02.83-90.

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Апелин - слово, появившееся в 1998 году. Так, по аббревиатуре рецептора APJ, авторы назвали, найденный ими лиганд этого рецептора. Существует в нескольких изоформах, от 13 до 77 аминокислотных остатков. Наиболее активна самая короткая форма: апелин-13. Образуется жировой и мышечной тканью - адипокин и миокин. В экспериментах на мышах обнаружено много положительных эффектов действия апелина, в том числе торможение развития старости. В нарастающем потоке клинических результатов есть сообщения о благоприятном действии апелина при нарушениях энергетического обмена, сердечно-сосудистой патологии, г

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SUZUKI, KEIKO. "Studies on estimation of hypotensive effect by hypotensive drugs." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 21, no. 1 (1990): 143–44. http://dx.doi.org/10.3999/jscpt.21.143.

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8

Abdul-Ghani, A. S., R. Amin, and M. S. Suleiman. "Hypotensive Effect ofCrataegus oxyacantha." International Journal of Crude Drug Research 25, no. 4 (1987): 216–20. http://dx.doi.org/10.3109/13880208709055196.

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Villar, A., M. J. Sanz, and M. Paya. "Hypotensive Effect ofPistacia lentiscusL." International Journal of Crude Drug Research 25, no. 1 (1987): 1–3. http://dx.doi.org/10.3109/13880208709060902.

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PRIETO, Juan Carlos, Mónica QUEVEDO, Hugo F. MIRANDA, and Gianni PINARDI. "Hypotensive effect of dopamine." Acta Cardiologica 60, no. 3 (2005): 253–57. http://dx.doi.org/10.2143/ac.60.3.2005004.

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11

Henley, David E., Fiona Buchanan, Rosemary Gibson, et al. "Plasma apelin levels in obstructive sleep apnea and the effect of continuous positive airway pressure therapy." Journal of Endocrinology 203, no. 1 (2009): 181–88. http://dx.doi.org/10.1677/joe-09-0245.

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Apelin is a peptide hormone with cardiovascular and glucose homeostasis properties, and obstructive sleep apnea (OSA) is complicated by cardiovascular and metabolic comorbidities. Plasma apelin has not been previously assessed in OSA. We investigated the response of plasma apelin to a 2-h 75 g oral glucose tolerance test (OGTT) and the effect of 3 months compliant continuous positive airway pressure (CPAP) therapy in 15 obese males with newly diagnosed OSA. Plasma apelin and serum cortisol were recorded 10 minutely, while serum insulin and glucose were measured 30 minutely. Ten subjects had pl

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12

Birsen, İlknur, V. Nimet İzgüt-Uysal, Hakan Soylu, and İsmail Üstünel. "The effect of apelin-13 on gastric ischemia/reperfusion injury: the roles of sensory nerves and vagus nerve." Canadian Journal of Physiology and Pharmacology 98, no. 5 (2020): 282–95. http://dx.doi.org/10.1139/cjpp-2019-0502.

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Apelin is a peptide that plays a role in physiological processes such as angiogenesis, apoptosis, and proliferation. The aim of this study was to investigate the role of capsaicin-sensitive afferent neurons and vagus in the effect of apelin against ischemia/reperfusion (I/R) injury. The experimental groups were (1) control, (2) I/R, (3) apelin + I/R, (4) vagotomy + I/R, (5) vagotomy + apelin + I/R, (6) capsaicin + I/R, (7) capsaicin + apelin + I/R, (8) lorglumide + I/R, and (9) lorglumide + apelin + I/R. To test the potential gastroprotective effect of apelin-13, apelin-13 (2 mg/kg i.v.) was a

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Benk Silfeler, Dilek, Cumali Gokce, Raziye Keskin Kurt, et al. "Does Polycystic Ovary Syndrome Itself Have Additional Effect on Apelin Levels?" Obstetrics and Gynecology International 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/536896.

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Objective. The present study was designed to compare serum levels of apelin between lean PCOS women and healthy women with regular menses.Study Design. A total of 30 lean patients with PCOS and 30 healthy subjects were included in this study. Serum apelin levels were compared between groups.Results. Serum apelin levels in lean PCOS patients were not significantly different from the control subjects.Conclusion. Our findings indicate that PCOS itself does not seem to change apelin levels. Further investigation on a large number of subjects will need to be conducted to prove the consistent or var

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Murza, Alexandre, Élie Besserer-Offroy, Jérôme Côté, et al. "C-Terminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action." Journal of Medicinal Chemistry 58, no. 5 (2015): 2431–40. http://dx.doi.org/10.1021/jm501916k.

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15

Castan-Laurell, Isabelle, Michaela Vítkova, Danièle Daviaud, et al. "Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ." European Journal of Endocrinology 158, no. 6 (2008): 905–10. http://dx.doi.org/10.1530/eje-08-0039.

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ObjectiveApelin is a novel adipokine acting on APJ receptor, regulated by insulin and tumor necrosis factor-α (TNF-α) in adipose tissue (AT). Plasma apelin levels are increased in obese hyperinsulinemic subjects. The aim was to investigate whether the hypocaloric diet associated with weight loss modifies the elevated plasma apelin levels and the expression of apelin and APJ receptor in AT in obese women.Design and methodsFasting plasma levels of apelin and TNF-α as well as mRNA levels of apelin and APJ in AT were measured before and after a 12-week hypocaloric weight-reducing diet in 20 obese

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16

Kutlay, Özden, Arzu Keskin Aktan, and Esra Aslan. "The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide." Canadian Journal of Physiology and Pharmacology 100, no. 4 (2022): 314–23. http://dx.doi.org/10.1139/cjpp-2021-0337.

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Cyclophosphamide is a chemotherapeutic drug that is widely used in the clinic and can cause multi-organ toxicity. Apelin-13 is an endogenous adipocytokine with antioxidant properties. Therefore, this study investigated the possibility of apelin-13 being a potential therapeutic agent on cardiac toxicity and nephrotoxicity caused by cyclophosphamide. In this study, a total of four groups were formed with eight rats in each group. Group I: the control group was administered only saline (i.p.). Group II: cyclophosphamide, a single dose of 200 mg/kg (i.p.) on day 7. Group III: apelin-13 (15 μg/kg),

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Chen, Guona, Xiaoting Liang, Qian Han, et al. "Apelin-13 Pretreatment Promotes the Cardioprotective Effect of Mesenchymal Stem Cells against Myocardial Infarction by Improving Their Survival." Stem Cells International 2022 (March 21, 2022): 1–15. http://dx.doi.org/10.1155/2022/3742678.

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Although mesenchymal stem cell- (MSC-) based therapy has shown promising results for myocardial infarction (MI), low cell survival heavily limits its beneficial effects. Apelin plays an essential regulatory role in cell proliferation. This study was aimed at determining whether Apelin-13 pretreatment could improve the survival of MSCs in the ischemic heart and enhance their cardioprotective efficacy against MI. MSCs were pretreated with or without Apelin-13 for 24 hours and then exposed to serum deprivation and hypoxia (SD/H) for 48 hours. The mitochondrial morphology of MSCs was assessed by M

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Stupak, Aleksandra, Wojciech Kwaśniewski, Anna Goździcka-Józefiak, and Anna Kwaśniewska. "The Influence of Maternal Obesity on Cell-Free Fetal DNA and Blood Pressure Regulation in Pregnancies with Hypertensive Disorders." Medicina 57, no. 9 (2021): 962. http://dx.doi.org/10.3390/medicina57090962.

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Background and Objectives: obesity and blood pressure disorders are one of the main risk factors for antenatal, intra, postpartum, and neonatal complications. In preeclampsia (PE), the placental hypoxia leads to vascular endothelium dysfunction, cell necrosis, and apoptosis. This condition is associated with the release of free fetal DNA (cffDNA) circulating in plasma. The disturbance of the efficiency of vasodilatation and blood pressure regulation in PE can be confirmed by analyzing the apelin, salusin, and prosalusin. This study aimed to assess the influence of obesity on cffDNA, and the ef

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Fibbi, Benedetta, Giada Marroncini, Laura Naldi, and Alessandro Peri. "The Yin and Yang Effect of the Apelinergic System in Oxidative Stress." International Journal of Molecular Sciences 24, no. 5 (2023): 4745. http://dx.doi.org/10.3390/ijms24054745.

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Apelin is an endogenous ligand for the G protein-coupled receptor APJ and has multiple biological activities in human tissues and organs, including the heart, blood vessels, adipose tissue, central nervous system, lungs, kidneys, and liver. This article reviews the crucial role of apelin in regulating oxidative stress-related processes by promoting prooxidant or antioxidant mechanisms. Following the binding of APJ to different active apelin isoforms and the interaction with several G proteins according to cell types, the apelin/APJ system is able to modulate different intracellular signaling p

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Day, Robert T., Rita C. Cavaglieri, and Denis Feliers. "Apelin retards the progression of diabetic nephropathy." American Journal of Physiology-Renal Physiology 304, no. 6 (2013): F788—F800. http://dx.doi.org/10.1152/ajprenal.00306.2012.

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Apelin and its receptor APJ have pleiotropic effects in mice and humans and play a protective role in cardiovascular diseases at least partially by inhibiting oxidative stress. Our objective was to study the effect of apelin on the progression of kidney disease in mice with established type 1 diabetes. Ove26 mice with type 1 diabetes received daily subcutaneous injections of apelin for 2 or 14 wk. APJ localizes in the glomeruli and blood vessels of kidneys. Renal APJ expression was reduced in diabetic mice but increased after treatment with apelin. Apelin treatment did not affect glycemia, bod

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Xu, Gang, Xianming Li, Dong Yang, Shihai Wu, Dong Wu та Maosheng Yan. "Bioinformatics Study of RNA Interference on the Effect of HIF-1α on Apelin Expression in Nasopharyngeal Carcinoma Cells". Current Bioinformatics 14, № 5 (2019): 386–90. http://dx.doi.org/10.2174/1574893614666190109155825.

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Background: HIF-1α can affect the apelin expression and participates in the developments in cancers but the mechanism need to be explored further. Objective: This paper investigates apelin expression in nasopharyngeal carcinoma CNE-2 cells and its regulation by hypoxia inducible factor-1α (HIF-1α) under hypoxic conditions. Methods: CoCl2 was used to induce hypoxia in CNE-2 cells for 12h, 24h and 48h. HIF-1α small interference RNA (siRNA) was transfected into CNE-2 cells using a transient transfection method. HIF-1α and apelin mRNA levels were detected by real time PCR. Western blot was used to

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Ishiguro, Koji, Makoto Yoshimoto, Masahito Tsubata, and Kinya Takagaki. "Hypotensive Effect of Sweetpotato Tops." Nippon Shokuhin Kagaku Kogaku Kaishi 54, no. 1 (2007): 45–49. http://dx.doi.org/10.3136/nskkk.54.45.

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Mlyczyńska, Ewa, Małgorzata Myszka, Patrycja Kurowska, et al. "Anti-Apoptotic Effect of Apelin in Human Placenta: Studies on BeWo Cells and Villous Explants from Third-Trimester Human Pregnancy." International Journal of Molecular Sciences 22, no. 5 (2021): 2760. http://dx.doi.org/10.3390/ijms22052760.

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Previously, we demonstrated the expression of apelin and G-protein-coupled receptor APJ in human placenta cell lines as well as its direct action on placenta cell proliferation and endocrinology. The objective of this study was to examine the effect of apelin on placenta apoptosis in BeWo cells and villous explants from the human third trimester of pregnancy. The BeWo cells and villous explants were incubated with apelin (2 and 20 ng/mL) alone or with staurosporine for 24 to 72 h. First, we analysed the dose- and time-dependent effect of apelin on the expression of apoptotic factors on the mRN

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Wang, Chen, Jun-Feng Du, Feng Wu, and Hai-Chang Wang. "Apelin decreases the SR Ca2+ content but enhances the amplitude of [Ca2+]i transient and contractions during twitches in isolated rat cardiac myocytes." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 6 (2008): H2540—H2546. http://dx.doi.org/10.1152/ajpheart.00046.2008.

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Apelin has been reported to have a positive inotropic action in the isolated rat heart. However, the effect of apelin on sarcoplasmic reticulum (SR) Ca2+ content and its influence on intracellular Ca2+ transient during excitation-contraction coupling remains poorly understood. In the present study, we determined the effect of apelin on Ca2+ transient and contractions in isolated rat cardiomyocytes. When compared with control, treatment with apelin caused a 55.7 ± 13.9% increase in sarcomere fraction shortening and a 43.6 ± 4.56% increase in amplitude of electrical-stimulated intracellular Ca2+

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Berezin, Alexander A., Ivan M. Fushtey, and Alexander E. Berezin. "The Effect of SGLT2 Inhibitor Dapagliflozin on Serum Levels of Apelin in T2DM Patients with Heart Failure." Biomedicines 10, no. 7 (2022): 1751. http://dx.doi.org/10.3390/biomedicines10071751.

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Apelin is a multifunctional peptide that plays a pivotal role in cardiac remodeling and HF manifestation because of counteracting angiotensin-II. We hypothesized that positive influence of sodium-glucose co-transporter-2 (SGLT2) inhibitor on cardiac function in T2DM patients with HF might be mediated by apelin and that its levels seem to be a target of management. A total of 153 type 2 diabetes mellitus (T2DM) patients with II/III HF NYHA class and average left ventricular (LV) ejection fraction (EF) of 46% have been enrolled and treated with dapagliflosin. The serum levels of apelin and N-ter

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Kurowska, Patrycja, Alix Barbe, Marta Różycka, Justyna Chmielińska, Joelle Dupont, and Agnieszka Rak. "Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review." International Journal of Endocrinology 2018 (June 6, 2018): 1–12. http://dx.doi.org/10.1155/2018/9170480.

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Apelin has been isolated from the bovine stomach extracts as an endogenous ligand of the previously orphan receptor APJ. Expression of the apelinergic system (apelin and APJ) was described in many organs where pleiotropic effects like regulation of food intake, body weight, or cardiovascular and immune function were described. Recent studies have shown that apelin also plays an important role in the regulation of female and male reproduction. Some data showed that the gene and protein of apelin/APJ are expressed in the hypothalamic-pituitary-gonad (HPG) axis tissue. Thus, apelin is synthesized

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Bülbül, Mehmet, V. Nimet İzgüt-Uysal, Osman Sinen, İlknur Birsen, and Gamze Tanrıöver. "Central apelin mediates stress-induced gastrointestinal motor dysfunction in rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 310, no. 4 (2016): G249—G261. http://dx.doi.org/10.1152/ajpgi.00145.2015.

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Apelin, an endogenous ligand for APJ receptor, has been reported to be upregulated in paraventricular nucleus (PVN) following stress. Central apelin is known to stimulate release of corticotropin-releasing factor (CRF) via APJ receptor. We tested the hypothesis that stress-induced gastrointestinal (GI) dysfunction is mediated by central apelin. We also assessed the effect of exogenous apelin on GI motility under nonstressed (NS) conditions in conscious rats. Prior to solid gastric emptying (GE) and colon transit (CT) measurements, APJ receptor antagonist F13A was centrally administered under N

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Rastaldo, Raffaella, Sandra Cappello, Anna Folino, and Gianni Losano. "Effect of Apelin-Apelin Receptor System in Postischaemic Myocardial Protection: A Pharmacological Postconditioning Tool?" Antioxidants & Redox Signaling 14, no. 5 (2011): 909–22. http://dx.doi.org/10.1089/ars.2010.3355.

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Jiang, He, Xiao-Ping Ye, Zhong-Yin Yang, et al. "Aldosterone directly affects apelin expression and secretion in adipocytes." Journal of Molecular Endocrinology 51, no. 1 (2013): 37–48. http://dx.doi.org/10.1530/jme-13-0025.

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There is a high incidence of metabolic syndrome among patients with primary aldosteronism (PA), which has recently been associated with an unfavorable cardiometabolic profile. However, the underlying mechanisms have not been clarified in detail. Characterizing aldosterone (Ald) target genes in adipocytes will help us to elucidate the deleterious effects associated with excess Ald. Apelin, a novel adipokine, exerts beneficial effects on obesity-associated disorders and cardiovascular homeostasis. The objective of this study was to investigate the effects of high Ald levels on apelin expression

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Hamza, Reham Z., Abdel Aziz A. Diab, Mansour H. Zahra, Ali K. Asalah, Mai S. Attia, and Suzan MM Moursi. "Ameliorative effect of apelin-13 against renal complications in L-NAME-induced preeclampsia in rats." PeerJ 9 (March 31, 2021): e11110. http://dx.doi.org/10.7717/peerj.11110.

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Pre-eclampsia (PE) accompanying acute liver and kidney injury has remained a master cause of both fetal and maternal mortality and morbidity. Vasoactive mediators, oxidative stress and inflammatory imbalanceshave an important role in PE pathogenesis. Apelin is an adipokine that improves endothelial dysfunction; has anti-inflammatory and antioxidant effects; moreover, its level reduced during PE. This study aimed to explore the effects of apelin-13 administration on preeclampsia-associated renal dysfunction and proteinuria. Thirty-three pregnant female rats were divided into three groups; group

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Chen, Li, Yong Tao, Jing Feng, and Yan Rong Jiang. "Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis." Journal of Ophthalmology 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/186946.

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Pericytes are a population of cells that participate in normal vessel architecture and regulate permeability. Apelin, as the endogenous ligand of G protein-coupled receptor APJ, participates in a number of physiological and pathological processes. To date, the effect of apelin on pericyte is not clear. Our study aimed to investigate the potential protection mechanisms of apelin, with regard to primary rat retinal pericytes under hypoxia. Immunofluorescence staining revealed that pericytes colocalized with APJ in the fibrovascular membranes dissected from proliferative diabetic retinopathy pati

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Tobin, Vicky A., Philip M. Bull, Sathya Arunachalam, Anne-Marie O'Carroll, Yoichi Ueta, and Mike Ludwig. "The Effects of Apelin on the Electrical Activity of Hypothalamic Magnocellular Vasopressin and Oxytocin Neurons and Somatodendritic Peptide Release." Endocrinology 149, no. 12 (2008): 6136–45. http://dx.doi.org/10.1210/en.2008-0178.

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Apelin, a novel peptide originally isolated from bovine stomach tissue extracts, is widely but selectively distributed throughout the nervous system. Vasopressin and oxytocin are synthesized in the magnocellular neurons of the hypothalamic supraoptic nucleus (SON) and paraventricular nucleus, which are apelin-rich regions in the central nervous system. We made extracellular electrophysiological recordings from the transpharyngeally exposed SON of urethane-anaesthetized rats to assess the role of apelin in the control of the firing activity of identified magnocellular vasopressin and oxytocin n

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Respekta, Natalia, Karolina Pich, Monika Dawid, Ewa Mlyczyńska, Patrycja Kurowska, and Agnieszka Rak. "The Apelinergic System: Apelin, ELABELA, and APJ Action on Cell Apoptosis: Anti-Apoptotic or Pro-Apoptotic Effect?" Cells 12, no. 1 (2022): 150. http://dx.doi.org/10.3390/cells12010150.

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The apelinergic system comprises two peptide ligands, apelin and ELABELA, and their cognate G-protein-coupled receptor, the apelin receptor APJ. Apelin is a peptide that was isolated from bovine stomach extracts; the distribution of the four main active forms, apelin-36, -17, -13, and pyr-apelin-13 differs between tissues. The mature form of ELABELA-32 can be transformed into forms called ELABELA-11 or -21. The biological function of the apelinergic system is multifaceted, and includes the regulation of angiogenesis, body fluid homeostasis, energy metabolism, and functioning of the cardiovascu

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Shpakov, A. O., and K. V. Derkach. "The Role of Apelin in the Functioning of the Reproductive System." Acta Biomedica Scientifica 4, no. 3 (2019): 7–17. http://dx.doi.org/10.29413/abs.2019-4.3.1.

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Adipokine apelin through the apelin receptors activates a wide range of signaling cascades in the target cells and controls their growth, differentiation, apoptosis, and energy metabolism. In the recent years, the evidence has been obtained that all components of the hypothalamic-pituitary-gonad axis, in which apelin and its receptor are expressed, are targets of apelin. In the hypothalamus, apelin modulates the activity of the melanocortin and ghrelin systems and indirectly affects the production of gonadoliberin. In the ovaries, it controls the growth and maturation of the follicles, stimula

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Akbari, Hamed, Mahnaz Hosseini-Bensenjan, Sarvenaz Salahi, et al. "Apelin and its ratio to lipid factors are associated with cardiovascular diseases: A systematic review and meta-analysis." PLOS ONE 17, no. 8 (2022): e0271899. http://dx.doi.org/10.1371/journal.pone.0271899.

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Background The present systematic review and meta-analysis aimed to ascertain if the circulating levels of apelin, as an important regulator of the cardiovascular homeostasis, differ in patients with cardiovascular diseases (CVDs) and controls. Methods A comprehensive search was performed in electronic databases including PubMed, Scopus, EMBASE, and Web of Science to identify the studies addressing apelin in CVD up to April 5, 2021. Due to the presence of different units to measure the circulating levels of apelin across the included studies, they expressed the standardized mean difference (SM

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Bodineau, Laurence, Christopher Taveau, Hong-Hanh Lê Quan Sang, et al. "Data Supporting a New Physiological Role for Brain Apelin in the Regulation of Hypothalamic Oxytocin Neurons in Lactating Rats." Endocrinology 152, no. 9 (2011): 3492–503. http://dx.doi.org/10.1210/en.2011-0206.

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Apelin is a bioactive peptide identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ in 1998. The present data show that apelin modulates the activity of magnocellular and parvocellular oxytocin (OXY) neurons in the lactating rat. A combination of in situ hybridization and immunohistochemistry demonstrated the presence of apelin receptor mRNA in hypothalamic OXY neurons. Double immunofluorescence labeling then revealed the colocalization of apelin with OXY in about 20% of the hypothalamic OXY-positive neurons. Intracerebroventricular apelin administration inhibi

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Xu, Gang, Xianming Li, Shihai Wu, Dong Yang, and Mao Sheng Yan. "Biostatistical Relationship Between Apelin Expression and Radiosensitization in Nasopharyngeal Carcinoma Cells Based on Flow Cytometry and Cell Imaging." Journal of Medical Imaging and Health Informatics 9, no. 8 (2019): 1575–82. http://dx.doi.org/10.1166/jmihi.2019.2765.

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Objective: To explore the biostatistical relationship between Apelin expression and radiosensitization in nasopharyngeal carcinoma (NPC) cells. Methods: The main operation of the experiment on NPC cells 6-10B and HNE2 include: colony formation, flow cytometry for radiotherapy, detection of cell proliferation according to the results of radiotherapy, protein immunoblotting for cells, detection of the effect of Apelin on the expression of hormones in cells by Western Blot method, immunofluorescence assay, electrophoresis, transmembrane closure, incubation of anti-cancer cells. The effects of Ape

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Vitale, Emanuela, Rachele Rosso, Marco Lo Iacono, Caterina Cristallini, Claudia Giachino, and Raffaella Rastaldo. "Apelin-13 Increases Functional Connexin-43 through Autophagy Inhibition via AKT/mTOR Pathway in the Non-Myocytic Cell Population of the Heart." International Journal of Molecular Sciences 23, no. 21 (2022): 13073. http://dx.doi.org/10.3390/ijms232113073.

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Studies have shown a link between the downregulation of connexin 43 (Cx43), the predominant isoform in cardiac gap junctions, and high susceptibility to cardiac arrhythmias and cardiomyocyte death. Non-myocytic cells (NMCs), the most abundant component of the heart, exert multiple cardiac functions and represent an important therapeutic target for diseased cardiac tissue. A few studies have investigated the effect of Apelin-13, an endogenous peptide with a key role in various cardiovascular functions, on Cx43 expression in cardiomyocytes. However, it remained unknown whether Apelin-13 influenc

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SUGIYAMA, Keikichi, Koji TAKADA, Makoto EGAWA, Ikuo YAMAMOTO, Hiromu ONZUKA, and Kenkichi ÔBA. "Hypotensive effect of fish protein hydrolysate." Journal of the agricultural chemical society of Japan 65, no. 1 (1991): 35–43. http://dx.doi.org/10.1271/nogeikagaku1924.65.35.

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Domaingue, Charles M., and Daryl H. Nye. "Hypotensive Effect of Mannitol Administered Rapidly." Anaesthesia and Intensive Care 13, no. 2 (1985): 134–36. http://dx.doi.org/10.1177/0310057x8501300204.

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Henning, M., та P. A. Zwieten. "Central Hypotensive Effect of α-methyldopa". Acta Pharmacologica et Toxicologica 25, S4 (2009): 25. http://dx.doi.org/10.1111/j.1600-0773.1967.tb03015.x.

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Villar, A., M. C. Terencio, and M. Paya. "Hypotensive effect of Rhamnus lycioides extracts." Journal of Ethnopharmacology 16, no. 2-3 (1986): 269–73. http://dx.doi.org/10.1016/0378-8741(86)90093-0.

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Sheikh, Ahmad Y., Hyung J. Chun, Alexander J. Glassford, et al. "In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 1 (2008): H88—H98. http://dx.doi.org/10.1152/ajpheart.00935.2007.

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Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has a potent inotropic effect on cardiac contractility and modulates systemic vascular resistance through nitric oxide-dependent signaling. In addition, there is evidence for counterregulation of the angiotensin and vasopressin pathways. Regulatory stimuli of the apelin-APJ pathway are of obvious importance but remain to be elucidated. To better understand the physiological response of apelin-APJ to disease states such as heart failure and to elucidate the mechanism by which such a response might occur, we ha

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Mishra, Aastha, Samantha Kohli, Sanchi Dua, Tashi Thinlas, Ghulam Mohammad, and M. A. Qadar Pasha. "Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema." Proceedings of the National Academy of Sciences 112, no. 19 (2015): 6134–39. http://dx.doi.org/10.1073/pnas.1422759112.

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Hypoxia-inducible factor stimulates the expression of apelin, a potent vasodilator, in response to reduced blood arterial oxygen saturation. However, aberrations in the apelin system impair pulmonary vascular function, potentially resulting in the development of high-altitude (HA)-related disorders. This study aimed to elucidate the genetic and epigenetic regulation of apelin, apelin receptor (APLNR), and endothelial nitric oxide synthase (NOS3) in HA adaptation and HA pulmonary edema (HAPE). A genome-wide association study and sequencing identified variants of apelin, APLNR, and NOS3 that wer

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Han, Xue, Dong-Liang Zhang, Dao-Xin Yin, Qi-Dong Zhang, and Wen-Hu Liu. "Apelin-13 deteriorates hypertension in rats after damage of the vascular endothelium by ADMA." Canadian Journal of Physiology and Pharmacology 91, no. 9 (2013): 708–14. http://dx.doi.org/10.1139/cjpp-2013-0046.

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Asymmetric dimethylarginine (ADMA) is a risk factor for endothelial dysfunction. The polypeptide apelin has biphasic effects on blood vessels in vivo and in vitro. We investigated the effect of apelin-13 on ADMA-damaged vessels. Rats were divided among ADMA-treated and control groups, which were treated with ADMA (10 mg·(kg body mass)−1·day−1) or saline, respectively, for 4 weeks. Systolic blood pressure (SBP) was measured before and after the injection of apelin-13. The ultrastructure of endothelial cells in caudal arteries was examined using transmission electron microscopy. The reactivities

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Wang, Sha, Guoying Gao, Yiwei He, Qiong Li, Zhan Li та Guoxiang Tong. "Amidation-Modified Apelin-13 Regulates PPARγ and Perilipin to Inhibit Adipogenic Differentiation and Promote Lipolysis". Bioinorganic Chemistry and Applications 2021 (7 травня 2021): 1–9. http://dx.doi.org/10.1155/2021/3594630.

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With the adjustment of human diet and lifestyle changes, the prevalence of obesity is increasing year by year. Obesity is closely related to the excessive accumulation of white adipose tissue (WAT), which can synthesize and secrete a variety of adipokines. Apelin is a biologically active peptide in the adipokines family. Past studies have shown that apelin plays an important regulatory role in the pathogenesis and pathophysiology of diseases such as the cardiovascular system, respiratory system, digestive system, nervous system, and endocrine system. Apelin is also closely related to diabetes

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Xu, Shu, Jian Zhang, Yin-li Xu, Hai-bo Wu, Xiao-dong Xue, and Hui-shan Wang. "Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/7951793.

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It has been shown that inflammation and oxidative stress are important factors in postoperative atrial fibrillation (POAF). Angiotensin converting enzyme (ACE) and apelin have a close relationship with inflammation and oxidative stress. The effect of ACE and apelin on POAF after off-pump coronary artery bypass grafting (OPCABG) remains a question. The concentrations of serum ACE, angiotensin II (Ang II), apelin, bradykinin (BK), malondialdehyde (MDA), and C reactive protein (CRP) were measured in the perioperative period of OPCABG. The levels of serum ACE in the POAF group were higher than in

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Mousa J. Humesh, AbduL-Monaim H.M. AL-Samarraie, and Zainab A.L. AL-Samarraie. "Apelin Levels and its Relationship with a Number of Electrolytes in Patients with Myocardial Infarction." Tikrit Journal of Pure Science 23, no. 3 (2018): 16–22. http://dx.doi.org/10.25130/tjps.v23i3.495.

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The study aimed to determine the effect of the lack of Apelin peptide and its relation to the development and severity of coronary atherosclerosis and to prove its association with acute myocardial infarction and the positive effect when increasing its concentration in the body and protect it from various diseases. The study included 70 patients of different ages infected with myocardial infarction, both high blood pressure and diabetes, were significantly presented in the group of patients in this study and were compared with control group, which included 35 samples of healthy people. The stu

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Marczewski, Kamil, Natalia Gospodarczyk, Alicja Gospodarczyk, Michał Widuch, and Michał Tkocz. "APELIN IN HEART FAILURE." Wiadomości Lekarskie 75, no. 10 (2022): 2501–6. http://dx.doi.org/10.36740/wlek202210130.

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Apelin is a biologically active protein encoded by the APLN gene. It was first isolated in 1998 as a ligand for the APJ receptor. It exists in several isoforms differing in polypeptide chain length and biological activity. It is secreted by white adipose tissue, and its expression has been identified in many body tissues, including the cardiovascular system, kidneys, lungs, CNS (especially the hypothalamus, suprachiasmatic and ventricular nuclei), skeletal muscle, mammary glands, adrenal glands, ovaries, stomach, liver cells, placenta, and breast milk. However, the highest concentrations were

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Tune, Johnathan D., Hana E. Baker, Zachary Berwick, et al. "Distinct hemodynamic responses to (pyr)apelin-13 in large animal models." American Journal of Physiology-Heart and Circulatory Physiology 318, no. 4 (2020): H747—H755. http://dx.doi.org/10.1152/ajpheart.00365.2019.

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This study tested the hypothesis that (pyr)apelin-13 dose-dependently augments myocardial contractility and coronary blood flow, irrespective of changes in systemic hemodynamics. Acute effects of intravenous (pyr)apelin-13 administration (10 to 1,000 nM) on blood pressure, heart rate, left ventricular pressure and volume, and coronary parameters were measured in dogs and pigs. Administration of (pyr)apelin-13 did not influence blood pressure ( P = 0.59), dP/d tmax ( P = 0.26), or dP/d tmin ( P = 0.85) in dogs. However, heart rate dose-dependently increased > 70% ( P < 0.01), which was ac

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