Academic literature on the topic 'Hypotensive effect of apelin'

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Journal articles on the topic "Hypotensive effect of apelin"

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Lee, Dennis K., Victor R. Saldivia, Tuan Nguyen, Regina Cheng, Susan R. George, and Brian F. O’Dowd. "Modification of the Terminal Residue of Apelin-13 Antagonizes Its Hypotensive Action." Endocrinology 146, no. 1 (2005): 231–36. http://dx.doi.org/10.1210/en.2004-0359.

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The apelin peptide is the endogenous ligand for the apelin G protein-coupled receptor. The distribution of the apelin peptides and receptor are widespread in the central nervous system and periphery, with reported roles in the hypothalamic-pituitary-adrenal axis, blood pressure regulation and as one of the most potent positive inotropic substances yet identified. In this report, we show that in native tissues preproapelin exists as a dimer. Dimeric preproapelin was reduced to monomers by dithiothreitol treatment, indicating disulfide linkages. To evaluate the role of the carboxyl-terminal phen
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Fernandez, Kleinberg X., Conrad Fischer, Jennie Vu, et al. "Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators." RSC Medicinal Chemistry 12, no. 8 (2021): 1402–13. http://dx.doi.org/10.1039/d1md00120e.

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Besserer-Offroy, Élie, Patrick Bérubé, Jérôme Côté та ін. "The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment". Pharmacological Research 131 (травень 2018): 7–16. http://dx.doi.org/10.1016/j.phrs.2018.02.032.

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Zhang, Rong, Jingyi Lu, Cheng Hu, et al. "Associations of Common Variants atAPLNand Hypertension in Chinese Subjects with and without Diabetes." Experimental Diabetes Research 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/917496.

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Background. Apelin, the endogenous ligand for the APJ receptor, has a potent hypotensive effect via a nitric oxide-dependent mechanism in vivo. The aim of the study was to investigate the association between the common variants of apelin gene (APLN) and hypertension, which was reported recently in a Chinese Han population with and without diabetes.Methods. Three single nucleotide polymorphisms (SNPs) onAPLNwere genotyped in 3156 diabetic patients and 3736 nondiabetic individuals. For non-diabetic subjects, 1779 were enrolled in stage 1 and 1757 were recruited for validation. A meta-analysis co
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Trojanowicz, Bogusz, Christof Ulrich, and Matthias Girndt. "Uremic Apelin and Leucocytic Angiotensin-Converting Enzyme 2 in CKD Patients." Toxins 12, no. 12 (2020): 742. http://dx.doi.org/10.3390/toxins12120742.

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Apelin peptides (APLN) serve as second substrates for angiotensin-converting enzyme 2 (ACE2) and, in contrast to angiotensin II (AngII), exert blood-pressure lowering and vasodilatation effects through binding to G-coupled APLN receptor (APLNR). ACE2-mediated cleavage of the APLN may reduce its vasodilatory effects, but decreased ACE2 may potentiate the hypotensive properties of APLN. The role of APLN in uremia is unclear. We investigated the correlations between serum-APLN, leucocytic APLNR, and ACE2 in 32 healthy controls (NP), 66 HD, and 24 CKD3–5 patients, and the impact of APLN peptides o
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Пальцын, А. А., and Н. Б. Свиридкина. "Apelin." Nauchno-prakticheskii zhurnal «Patogenez», no. 2 (June 28, 2021): 83–90. http://dx.doi.org/10.25557/2310-0435.2021.02.83-90.

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Апелин - слово, появившееся в 1998 году. Так, по аббревиатуре рецептора APJ, авторы назвали, найденный ими лиганд этого рецептора. Существует в нескольких изоформах, от 13 до 77 аминокислотных остатков. Наиболее активна самая короткая форма: апелин-13. Образуется жировой и мышечной тканью - адипокин и миокин. В экспериментах на мышах обнаружено много положительных эффектов действия апелина, в том числе торможение развития старости. В нарастающем потоке клинических результатов есть сообщения о благоприятном действии апелина при нарушениях энергетического обмена, сердечно-сосудистой патологии, г
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SUZUKI, KEIKO. "Studies on estimation of hypotensive effect by hypotensive drugs." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 21, no. 1 (1990): 143–44. http://dx.doi.org/10.3999/jscpt.21.143.

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Abdul-Ghani, A. S., R. Amin, and M. S. Suleiman. "Hypotensive Effect ofCrataegus oxyacantha." International Journal of Crude Drug Research 25, no. 4 (1987): 216–20. http://dx.doi.org/10.3109/13880208709055196.

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Villar, A., M. J. Sanz, and M. Paya. "Hypotensive Effect ofPistacia lentiscusL." International Journal of Crude Drug Research 25, no. 1 (1987): 1–3. http://dx.doi.org/10.3109/13880208709060902.

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PRIETO, Juan Carlos, Mónica QUEVEDO, Hugo F. MIRANDA, and Gianni PINARDI. "Hypotensive effect of dopamine." Acta Cardiologica 60, no. 3 (2005): 253–57. http://dx.doi.org/10.2143/ac.60.3.2005004.

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