Relevant bibliographies by topics / Hypoglycemia – Epidemiology

Academic literature on the topic 'Hypoglycemia – Epidemiology'

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Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Hypoglycemia – Epidemiology"

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Kim, Hae Jin. "Epidemiology of Hypoglycemia in Diabetes." Korean Clinical Diabetes 9, no. 2 (2008): 91. http://dx.doi.org/10.4093/kcd.2008.9.2.91.

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Klimontov, Vadim V. "Impaired hypoglycemia awareness in diabetes: epidemiology, mechanisms and therapeutic approaches." Diabetes mellitus 21, no. 6 (February 18, 2019): 513–23. http://dx.doi.org/10.14341/dm9597.

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Impaired awareness of hypoglycemia (IAH) is a frequent complication of insulin therapy. Up to half insulin-treated individuals with type 1 and type 2 diabetes report the problems with hypoglycemia awareness, and 1525% of patients have a permanent IAH. A recurrent hypoglycemia is a cornerstone in IAH formation. The repeated episodes of hypoglycemia impair neurohumoral response to hypoglycemia, reduce its symptoms and induce inadequate brain adaptation to low glucose levels. In this regard, the IAH phenomenon can be considered as an example of "metabolic memory" in diabetes. The IAH is associated with episodes of severe hypoglycemia, fear of hypoglycemia and cognitive dysfunction. These associates can be combined into IAH syndrome. Development of IAH becomes a serious barrier in diabetes management. A growing body of evidence indicates that IAH is a reversible condition. If the syndrome is present, the hypoglycemia avoidance should be primary goal of the treatment. Structured training under specialized programs with psychological support is the most reasonable therapeutic approach to IAH amending. Technological approaches, including continuous subcutaneous insulin infusion, real-time continuous glucose monitoring, closed-loop insulin delivery systems ("artificial pancreas"), and islet transplantation also showed efficacy in hypoglycemia awareness improvement in some clinical studies. The diabetes management in patients with IAH is time-consuming and expensive. Therefore, step-by-step approach, from insulin personalization and therapeutic training to advanced medical technologies, should be recommended for these patients.
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Ahmad, Iram, Leila R. Zelnick, Zona Batacchi, Nicole Robinson, Ashveena Dighe, Jo-Anne E. Manski-Nankervis, John Furler, et al. "Hypoglycemia in People with Type 2 Diabetes and CKD." Clinical Journal of the American Society of Nephrology 14, no. 6 (April 17, 2019): 844–53. http://dx.doi.org/10.2215/cjn.11650918.

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Background and objectivesAmong people with diabetes mellitus, CKD may promote hypoglycemia through altered clearance of glucose-lowering medications, decreased kidney gluconeogenesis, and blunted counter-regulatory response. We conducted a prospective observational study of hypoglycemia among 105 individuals with type 2 diabetes treated with insulin or a sulfonylurea using continuous glucose monitors.Design, setting, participants & measurementsWe enrolled 81 participants with CKD, defined as eGFR<60 ml/min per 1.73 m2, and 24 control participants with eGFR≥60 ml/min per 1.73 m2 frequency-matched on age, duration of diabetes, hemoglobin A1c, and glucose-lowering medications. Each participant wore a continuous glucose monitor for two 6-day periods. We examined rates of sustained level 1 hypoglycemia (<70 mg/dl) and level 2 hypoglycemia (<54 mg/dl) among participants with CKD. We then tested differences compared with control participants as well as a second control population (n=73) using Poisson and linear regression, adjusting for age, sex, and race.ResultsOver 890 total days of continuous glucose monitoring, participants with CKD were observed to have 255 episodes of level 1 hypoglycemia, of which 68 episodes reached level 2 hypoglycemia. Median rate of hypoglycemic episodes was 5.3 (interquartile range, 0.0–11.7) per 30 days and mean time spent in hypoglycemia was 28 (SD 37) minutes per day. Hemoglobin A1c and the glucose management indicator were the main clinical correlates of time in hypoglycemia (adjusted differences 6 [95% confidence interval, 2 to 10] and 13 [95% confidence interval, 7 to 20] fewer minutes per day per 1% higher hemoglobin A1c or glucose management indicator, respectively). Compared with control populations, participants with CKD were not observed to have significant differences in time in hypoglycemia (adjusted differences 4 [95% confidence interval, −12 to 20] and −12 [95% confidence interval, −29 to 5] minutes per day).ConclusionsAmong people with type 2 diabetes and moderate to severe CKD, hypoglycemia was common, particularly with tighter glycemic control, but not significantly different from groups with similar clinical characteristics and preserved eGFR.
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Van Staa, Tjeerd, Lucien Abenhaim, and Johanne Monette. "Rates of hypoglycemia in users of sulfonylureas." Journal of Clinical Epidemiology 50, no. 6 (June 1997): 735–41. http://dx.doi.org/10.1016/s0895-4356(97)00024-3.

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Kumar, JuvvaGowtham, KPP Abhilash, RamaPrakasha Saya, Neeha Tadipaneni, and JMaheedhar Bose. "A retrospective study on epidemiology of hypoglycemia in Emergency Department." Indian Journal of Endocrinology and Metabolism 21, no. 1 (2017): 119. http://dx.doi.org/10.4103/2230-8210.195993.

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Awoniyi, Omodele, Rabia Rehman, and Samuel Dagogo-Jack. "Hypoglycemia in Patients with Type 1 Diabetes: Epidemiology, Pathogenesis, and Prevention." Current Diabetes Reports 13, no. 5 (August 4, 2013): 669–78. http://dx.doi.org/10.1007/s11892-013-0411-y.

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Ginde, A. A., R. M. Lieberman, D. J. Pallin, and C. A. Camargo. "169: Emergency Department Visits for Hypoglycemia: Epidemiology, Patient Education and Outcomes." Annals of Emergency Medicine 50, no. 3 (September 2007): S54. http://dx.doi.org/10.1016/j.annemergmed.2007.06.202.

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Min, Jea Young, Caroline A. Presley, Jennifer Wharton, Marie R. Griffin, Robert A. Greevy, Adriana M. Hung, Jonathan Chipman, Carlos G. Grijalva, Amber J. Hackstadt, and Christianne L. Roumie. "Accuracy of a composite event definition for hypoglycemia." Pharmacoepidemiology and Drug Safety 28, no. 5 (March 6, 2019): 625–31. http://dx.doi.org/10.1002/pds.4712.

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Ratzki-Leewing, Alexandria, Stewart B. Harris, Selam Mequanint, Sonja M. Reichert, Judith Belle Brown, Jason Edward Black, and Bridget L. Ryan. "Real-world crude incidence of hypoglycemia in adults with diabetes: Results of the InHypo-DM Study, Canada." BMJ Open Diabetes Research & Care 6, no. 1 (April 2018): e000503. http://dx.doi.org/10.1136/bmjdrc-2017-000503.

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ObjectiveVery few real-world studies have been conducted to assess the incidence of diabetes-related hypoglycemia. Moreover, there is a paucity of studies that have investigated hypoglycemia among people taking secretagogues as a monotherapy or in combination with insulin. Accordingly, our research team developed and validated the InHypo-DM Person with Diabetes Mellitus Questionnaire (InHypo-DMPQ) with the aim of capturing the real-world incidence of self-reported, symptomatic hypoglycemia. The questionnaire was administered online to a national sample of Canadians (≥18 years old) with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) treated with insulin and/or insulin secretagogues.Research design and methodsSelf-report data obtained from the InHypo-DMPQ were descriptively analyzed to ascertain the crude incidence proportions and annualized incidence densities (rates) of 30-day retrospective non-severe and 1-year retrospective severe hypoglycemia, including daytime and nocturnal events.ResultsA total of 552 people (T2DM: 83%; T1DM: 17%) completed the questionnaire. Over half (65.2%) of the total respondents reported experiencing at least one event (non-severe or severe) at an annualized crude incidence density of 35.1 events per person-year. The incidence proportion and rate of non-severe events were higher among people with T1DM versus T2DM (77% and 55.7 events per person-year vs 54% and 28.0 events per person-year). Severe hypoglycemia was reported by 41.8% of all respondents, at an average rate of 2.5 events per person-year.ConclusionsThe results of the InHypo-DMPQ, the largest real-world investigation of hypoglycemia epidemiology in Canada, suggest that the incidence of hypoglycemia among adults with diabetes taking insulin and/or insulin secretagogues is higher than previously thought.
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Brož, Jan, and Jana Urbanová. "A general view of epidemiology of hypoglycemia in type 1 and type 2 diabetes mellitus." Vnitřní lékařství 65, no. 4 (April 1, 2019): 289–94. http://dx.doi.org/10.36290/vnl.2019.050.

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Dissertations / Theses on the topic "Hypoglycemia – Epidemiology"

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Bulsara, Mahesh K. "Epidemiology of severe hypoglycaemia in children and adolescents with type 1 diabetes." Telethon Institute for Child Health Research, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0226.

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[Truncated abstract] Type 1 Diabetes is emerging as a significant public health problem faced by nearly every country in the world. It has major economic and social implications with considerable burden of illness. Approximately 140,000 Australians have been diagnosed with T1DM with an annual increase in incidence rate of 3% per year, comparable to the overall global increase. The management of T1DM requires insulin therapy which places considerable burden on the patient and their carers. Coping with daily insulin injections, dietary changes, modification of physical activity and vigilant monitoring of blood glucose levels, will impact on patient?s quality of life. The optimum goal for the treatment of type 1 diabetes is to safely achieve near-normal glycaemia and failure to maintain this goal accelerates the progression of the devastating long term complications of diabetes. Unfortunately attempts to achieve near normal glycaemia are limited by the risk of excessive lowering of blood glucose levels and hypoglycaemia remains a major barrier to strict glucose control of diabetes. In general this thesis focuses on two fundamental issues related to the epidemiology of severe hypoglycaemia. Namely, methodological consideration when analysing prospective observational data and application of the most robust methodology. A prospective open cohort study of the Princess Margaret Hospital diabetes clinic established in 1992, with 99% case ascertainment was used. This hospital is the only paediatric referral centre for type 1 diabetes and every child diagnosed in the state of Western Australia is treated at this centre. ... The results of this study showed that severe hypoglycaemia remains a major problem and recent approaches to therapy may be allowing a degree of improved control without the expected increased risk of severe hypoglycaemia. The study in chapter 7 investigates genetic risk factors related to severe hypoglycaemia. A significant relationship where the presence of the iv deletion (D) allele of the angiotensin-converting enzyme (ACE) increases risk of severe hypoglycaemia has been reported. This study concludes that the presence of D allele of the ACE gene does not predict a significantly higher risk of severe hypoglycaemia. In an attempt to optimize glycemic control, patients may suffer multiple episodes of severe hypoglycaemia which can adversely affect quality of life as well as educational and intellectual disadvantage. The study in chapter 8 investigates the factors related to recurrent severe hypoglycaemia. A rigorous and informative time-to-event approach is used to account for within child correlation, staggered enrolment and timevarying covariates. This allows important risk factors to change over time. Preschool children have an increased risk of experiencing recurrent severe hypoglycaemia. The findings of this thesis highlights the importance of selecting appropriate analytical methodology to identify risk factors associated with severe hypoglycaemia and also to dismiss factors that had previously been thought to be important. This will help in formulating management plans in order to limit the impact of severe hypoglycaemia.
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Nordfeldt, Sam. "On Severe Hypoglycaemia in Children and Adolescents with Type 1 Diabetes." Doctoral thesis, Linköping : Univ, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5018.

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Iser, Betine Pinto Moehlecke. "Prevalência de diabetes autorreferido em capitais brasileiras : estimativa a partir do Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por inquérito telefônico - VIGITEL." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/115618.

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Objetivo: estimar a prevalência de diabetes autorreferido e caracterizar o diagnóstico e o tratamento do diabetes em adultos de capitais brasileiras. Métodos: Analisaram-se questões adicionais de diabetes do Vigitel 2011, provenientes de 54.144 entrevistas telefônicas. Estimativas de prevalência e seus IC 95% levaram em conta os pesos amostrais atribuídos aos indivíduos entrevistados. Resultados: A prevalência de diabetes autorreferido foi de 5,6% (IC 95% 5,2 – 6,0), aumentando com idade e estado nutricional. O diagnóstico ocorreu aos ≥ 35 anos para 88% dos casos, em média 48 anos para homens e 47 anos para mulheres. A quase totalidade (99,9%) dos casos informou ter realizado exame de glicemia; apenas 28% dos que não referiram diagnóstico prévio não haviam realizado o exame. Um percentual pequeno (1,2%) dos casos não realizou glicemia ou o fez há mais de cinco anos e não faz tratamento para diabetes. A prevalência de diabetes autorreferido em tratamento para diabetes foi de 5,1% e em tratamento medicamentoso de 4,4% (3,4% na região Norte e 5,0% na Região Sudeste; 2,5% em Palmas e 5,1% em São Paulo). Entre os que não relataram ter diabetes, a realização de glicemia foi menor nos homens, nos mais jovens, nos de menor escolaridade e naqueles da região Norte. Conclusões: O elevado percentual de realização de glicemia na população apóia o uso do relato de diagnóstico prévio como medida de prevalência de diabetes. As demais questões permitiram caracterizar melhor o diagnóstico e o tratamento do diabetes, trazendo informações úteis para sua vigilância. Incertezas em relação aos possíveis falsos relatos persistem, limitando correções nas estimativas de prevalência de diabetes atualmente utilizadas. Outros estudos são necessários para estimar diretamente os falsos positivos e negativos e com maior precisão informar o número total de casos de diabetes.
Objective: To estimate the prevalence of self-reported diabetes and to describe diagnostic and treatment patterns in adults living in state capitals of Brazil. Methods: Questions about diabetes added in Vigitel 2011 were analyzed from 54,144 telephone interviews. Prevalence estimates are presented as proportions and confidence intervals, taking into account sample weights assigned to each participant. Results: Prevalence of self-reported diabetes was 5.6% (CI 5.2-6.0) with increasing rates according to age and nutritional status. Diagnosis occurred at ≥ 35 years of age in 88% of cases, on average 48 years for men and 47 for women. Almost all (99.9%) cases of diabetes informed having done a previous glucose test; only 28% of the non cases informed not having done a previous test. A small proportion (1.2%) of cases did not perform a glucose test or did so more than five years before the interview. The prevalence of self-reported diabetes based on being under any type of treatment was 5.1%, and under drug treatment, 4.4% (varying from 3.4% on the North Region to 5.0% on the Southeast and from 2.5% in Palmas to 5.1% in São Paulo). Among non cases, blood glucose testing was less frequent in men, in younger adults, in less educated and in those living in the North region. Conclusions: The high percentage of glucose testing strengthens the use of self-reported diabetes as a measure of diabetes prevalence. The additional questions to Vigitel 2011 allowed a better description of the diagnostic and treatment patterns of diabetes for the means in surveillance. Uncertainty remains about possible false reports, thus limiting corrections in current estimates of diabetes prevalence. Further studies need to be done to estimate directly false reports so as to estimate more accurately the total number and characteristics of cases of diabetes.
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Book chapters on the topic "Hypoglycemia – Epidemiology"

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Rewers, Alberta B. "Epidemiology of Acute Complications: Diabetic Ketoacidosis, Hyperglycemic Hyperosmolar State and Hypoglycemia." In The Epidemiology of Diabetes Mellitus, 577–602. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/9780470779750.ch35.

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Frier, Brian M., and Simon R. Heller. "1. Epidemiology and Impact of Hypoglycemia on Patients with Diabetes." In Translational Endocrinology & Metabolism: Hypoglycemia in Diabetes Update, 15–46. 8401 Connecticut Avenue, Suite 900, Chevy Chase, Maryland 20815: The Endocrine Society, 2012. http://dx.doi.org/10.1210/team.9781936704200.ch1.

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