Journal articles on the topic 'Hyperthermia'
To see the other types of publications on this topic, follow the link: Hyperthermia.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Hyperthermia.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Schlader, Zachary J., Thomas Seifert, Thad E. Wilson, Morten Bundgaard-Nielsen, Niels H. Secher, and Craig G. Crandall. "Acute volume expansion attenuates hyperthermia-induced reductions in cerebral perfusion during simulated hemorrhage." Journal of Applied Physiology 114, no. 12 (June 15, 2013): 1730–35. http://dx.doi.org/10.1152/japplphysiol.00079.2013.
Full textAbstract:
Hyperthermia reduces the capacity to withstand a simulated hemorrhagic challenge, but volume loading preserves this capacity. This study tested the hypotheses that acute volume expansion during hyperthermia increases cerebral perfusion and attenuates reductions in cerebral perfusion during a simulated hemorrhagic challenge induced by lower-body negative pressure (LBNP). Eight healthy young male subjects underwent a supine baseline period (pre-LBNP), followed by 15- and 30-mmHg LBNP while normothermic, hyperthermic (increased pulmonary artery blood temperature ∼1.1°C), and following acute volume infusion while hyperthermic. Primary dependent variables were mean middle cerebral artery blood velocity (MCAvmean), serving as an index of cerebral perfusion; mean arterial pressure (MAP); and cardiac output (thermodilution). During baseline, hyperthermia reduced MCAvmean ( P = 0.001) by 12 ± 9% relative to normothermia. Volume infusion while hyperthermic increased cardiac output by 2.8 ± 1.4 l/min ( P < 0.001), but did not alter MCAvmean ( P = 0.99) or MAP ( P = 0.39) compared with hyperthermia alone. Relative to hyperthermia, at 30-mmHg LBNP acute volume infusion attenuated reductions ( P < 0.001) in cardiac output (by 2.5 ± 0.9 l/min; P < 0.001), MAP (by 5 ± 6 mmHg; P = 0.004), and MCAvmean (by 12 ± 13%; P = 0.002). These data indicate that acute volume expansion does not reverse hyperthermia-induced reductions in cerebral perfusion pre-LBNP, but that it does attenuate reductions in cerebral perfusion during simulated hemorrhage in hyperthermic humans.
2
Trinity, Joel D., Matthew D. Pahnke, Joshua F. Lee, and Edward F. Coyle. "Interaction of hyperthermia and heart rate on stroke volume during prolonged exercise." Journal of Applied Physiology 109, no. 3 (September 2010): 745–51. http://dx.doi.org/10.1152/japplphysiol.00377.2010.
Full textAbstract:
People who become hyperthermic during exercise display large increases in heart rate (HR) and reductions in stroke volume (SV). It is not clear if the reduction in SV is due primarily to hyperthermia or if it is a secondary effect of an elevation in HR reducing ventricular filling. In the present study, the upward drift of HR during prolonged exercise was prevented by a very small dose of the β1-adrenoreceptor blocker (atenolol; βB), thus allowing SV to be compared at a given HR during normothermia and hyperthermia. Eleven men cycled for 60 min at 57% of peak O2 uptake after receiving placebo control (PL) or a low dose (0.2 mg/kg) of βB. Hyperthermia was induced by reducing heat dissipation during exercise. Four experimental conditions were studied: normothermia-PL, normothermia-βB, hyperthermia-PL, and hyperthermia-βB. Hyperthermia increased skin and core temperature by 4.3°C and 0.8°C ( P < 0.01), respectively. βB prevented HR elevation with hyperthermia: HR values were similar at minute 60 during normothermia-PL and hyperthermia-βB (155 ± 11 and 154 ± 13 beats/min, respectively, P = 0.82). However, SV was increased by 7% during the final 20 min of exercise during hyperthermia-βB compared with normothermia-PL (treatment × time interaction, P = 0.03). In conclusion, when matched for HR, mild hyperthermia increased SV during exercise. Furthermore, the reduction in SV throughout prolonged exercise under normothermic and mildly hyperthermic conditions appears to be due to the increase in HR.
3
Mammar, Mohamed Sidi, Xavier Vignon, Edmond Rock, Frederique Mathieu, and Gilles Gandemer. "Analysis of lipid composition of sarcoplasmic reticulum membranes from normal and malignant hyperthermic pig skeletal muscle." Biochemistry and Cell Biology 71, no. 7-8 (July 1, 1993): 324–30. http://dx.doi.org/10.1139/o93-049.
Full textAbstract:
In search of a general membrane defect hypothesis for malignant hyperthermia syndrome, we analysed the lipid profiles of heavy sarcoplasmic reticulum membranes isolated from normal and malignant hyperthermia longissimus dorsi pig muscle. Malignant hyperthermia susceptibility was assessed by halothane challenge of pigs. Sarcoplasmic reticulum membranes from malignant hyperthermia susceptible pigs differed significantly from control ones in the cholesterol content and phosphatidylethanolamine/phosphatidylcholine ratio; both were higher in former membranes. These latter lipid modifications were in agreement with the significant increase of their bulk lipid viscosity, as evidenced by an increase of diphenyl hexatriene fluorescence anisotropy. The increased level of phosphatidylethanolamine associated with the decreased content of phosphatidylcholine in malignant hyperthermic membranes was shown to be a potential consequence of depressed activities of both phospholipid N-methyltransferase I and II activities. Finally, the distribution of fatty acids in these particular phospholipids showed no change in phosphatidylcholine molecules, whereas the percentage of arachidonate and stearate in the phosphatidylethanolamine species were respectively higher and lower in malignant hyperthermic membranes. These differences in major phospholipids content and the enrichment of a metabolically important fatty acyl chains in malignant hyperthermia sarcoplasmic reticulum membranes strongly suggest that the lipid metabolism may contribute to the molecular mechanism of malignant hyperthermia syndrome.Key words: malignant hyperthermia, sacroplasmic reticulum, ryanodine, phospholipid N-methyltransferase, fluidity.
4
Holt, David W. "Hyperthermia in Extracorporeal Technology." Journal of ExtraCorporeal Technology 21, no. 2 (June 1989): 65–72. http://dx.doi.org/10.1051/ject/1989212065.
Full textAbstract:
A review of the application of hyperthermia in the treatment of cancer is presented. The definition, historical background, biological rationale, indications and contraindications are discussed. The five basic methods of inducing hyperthermia as well as the five objective therapeutic modalities are reviewed. Hyperthermia for the treatment of cancer applied by extracorporeal circulation either alone or in conjunction with isolated regional perfusion is the specific target of the review. The published results demonstrating hyperthermic therapy as a “detrimental” therapy, an “indifferent” therapy or a “positive” therapy are explored (J. Extra-Corpor. Technol. 21(2): 65-72, 1989, 83 Ref).
5
Tryba, Andrew K., and Jan-Marino Ramirez. "Hyperthermia Modulates Respiratory Pacemaker Bursting Properties." Journal of Neurophysiology 92, no. 5 (November 2004): 2844–52. http://dx.doi.org/10.1152/jn.00752.2003.
Full textAbstract:
Most mammals modulate respiratory frequency (RF) to dissipate heat (e.g., panting) and avoid heat stroke during hyperthermic conditions. Respiratory neural network activity recorded in an isolated brain stem-slice preparation of mice exhibits a similar RF modulation in response to hyperthermia; fictive eupneic frequency increases while inspiratory network activity amplitude and duration are significantly reduced. Here, we study the effects of hyperthermia on the activity of synaptically isolated respiratory pacemakers to examine the possibility that these changes may account for the hyperthermic RF modulation of the respiratory network. During heating, modulation of the bursting frequency of synaptically isolated pacemakers paralleled that of population bursting recorded from the intact network, whereas nonpacemaker neurons were unaffected, suggesting that pacemaker bursting may account for the temperature-enhanced RF observed at the network level. Some respiratory neurons that were tonically active at hypothermic conditions exhibited pacemaker properties at approximately the normal body temperature of eutherian mammals (36.81 ± 1.17°C; mean ± SD) and continued to burst at 40°C. At elevated temperatures (40°C), there was an enhancement of the depolarizing drive potential in synaptically isolated pacemakers, while the amplitude of integrated population activity declined. Isolated pacemaker bursting ceased at 41–42°C ( n = 5), which corresponds to temperatures at which hyperthermic-apnea typically occurs in vivo. We conclude that pacemaker properties may play an important role in the hyperthermic frequency modulation and apnea, while network effects may play important roles in generating other aspects of the hyperthermic response, such as the decreased amplitude of ventral respiratory group activity during hyperthermia.
6
José, González-Alonso,, Ricardo Mora-Rodríguez, Paul R. Below, and Edward F. Coyle. "Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise." Journal of Applied Physiology 82, no. 4 (April 1, 1997): 1229–36. http://dx.doi.org/10.1152/jappl.1997.82.4.1229.
Full textAbstract:
González-Alonso, José, Ricardo Mora-Rodrı́guez, Paul R. Below, and Edward F. Coyle.Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise. J. Appl. Physiol. 82(4): 1229–1236, 1997.—We identified the cardiovascular stress encountered by superimposing dehydration on hyperthermia during exercise in the heat and the mechanisms contributing to the dehydration-mediated stroke volume (SV) reduction. Fifteen endurance-trained cyclists [maximal O2consumption (V˙o2 max) = 4.5 l/min] exercised in the heat for 100–120 min and either became dehydrated by 4% body weight or remained euhydrated by drinking fluids. Measurements were made after they continued exercise at 71%V˙o2 maxfor 30 min while 1) euhydrated with an esophageal temperature (Tes) of 38.1–38.3°C (control); 2) euhydrated and hyperthermic (39.3°C); 3) dehydrated and hyperthermic with skin temperature (Tsk) of 34°C; 4) dehydrated with Tesof 38.1°C and Tskof 21°C; and 5) condition 4 followed by restored blood volume. Compared with control, hyperthermia (1°C Tesincrease) and dehydration (4% body weight loss) each separately lowered SV 7–8% (11 ± 3 ml/beat; P < 0.05) and increased heart rate sufficiently to prevent significant declines in cardiac output. However, when dehydration was superimposed on hyperthermia, the reductions in SV were significantly ( P< 0.05) greater (26 ± 3 ml/beat), and cardiac output declined 13% (2.8 ± 0.3 l/min). Furthermore, mean arterial pressure declined 5 ± 2%, and systemic vascular resistance increased 10 ± 3% (both P < 0.05). When hyperthermia was prevented, all of the decline in SV with dehydration was due to reduced blood volume (∼200 ml). These results demonstrate that the superimposition of dehydration on hyperthermia during exercise in the heat causes an inability to maintain cardiac output and blood pressure that makes the dehydrated athlete less able to cope with hyperthermia.
7
Baugher, Paige J. "Abstract 2878: Hyperthermia increases the efficacy of aminolevulinic acid-mediated photodynamic therapy in human osteosarcoma cells." Cancer Research 84, no. 6_Supplement (March 22, 2024): 2878. http://dx.doi.org/10.1158/1538-7445.am2024-2878.
Full textAbstract:
Abstract Osteosarcoma is a malignant osteoid tumor that arises from mesenchymal cells exhibiting osteoblastic differentiation. Common treatments for this neoplasm include limb-salvage surgery and/or amputation of the affected limb, either of which can substantially decrease quality of life. Therefore, other, less invasive treatments should be explored. Photodynamic therapy (PDT) represents a more targeted, less invasive treatment possibility for osteosarcoma. Previous data from my laboratory demonstrated that aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) can be used to induce significant cell death in human osteosarcoma MG-63 cells in vitro. However, delivering high doses of drugs to deep osteosarcoma tumors could prove difficult, so we aim to explore the use of combination therapies to increase the efficacy of ALA-PDT in human osteosarcoma cells. Previous studies have shown that hyperthermia (increased temperature) can induce cell death in cancer cells. Furthermore, data suggest that combining PDT with hyperthermia can induce cell death in cancer cells synergistically by activating differential death-inducing pathways. However, hyperthermia in combination with ALA-PDT has not been explored in human osteosarcoma. Therefore, we aim to investigate the possibility that hyperthermia in combination with ALA-PDT can increase cell death in human osteosarcoma cells compared to ALA-PDT alone. Data from our lab show that compared to normal body temperature (37°C), cell death in MG-63 human osteosarcoma cells was not significantly increased by mild hyperthermia alone (40°C and 43°C respectively), while moderate hyperthermic temperatures alone (46°C and 49°C) did significantly increase cell death. We also found that at moderately hyperthermic temperatures, ALA-PDT does not increase cell death any further compared to moderate hyperthermia alone. Furthermore, we found that at the mildly hyperthermic temperature of 40°C, cell death was not significantly increased any further by ALA-PDT compared to ALA-PDT alone. However, our data do show that at a temperature of 43°C, hyperthermia plus ALA-PDT increased cell death compared to ALA-PDT alone. Therefore, our data suggest that inducing mild hyperthermia could increase the efficacy of ALA-PDT in human osteosarcoma cells. Citation Format: Paige J. Baugher. Hyperthermia increases the efficacy of aminolevulinic acid-mediated photodynamic therapy in human osteosarcoma cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2878.
8
Vertrees, Roger A., Joseph B. Zwischenberger, Lee C. Woodson, Eric A. Bedell, Donald J. Deyo, and Jill M. Chernin. "Veno-venous perfusion-induced systemic hyperthermia: case report with perfusion considerations." Perfusion 16, no. 3 (May 2001): 243–48. http://dx.doi.org/10.1177/026765910101600310.
Full textAbstract:
Cancer cells are more susceptible to destruction by heat than are their normal counterparts. However, optimization of this hyperthermic susceptibility for selective cancer cell kill has been difficult to define and technically difficult to achieve. A whole-body hyperthermic technique - veno-venous perfusion-induced systemic hyperthermia (VV-PISH) was designed in in vitro and in swine experiments to achieve selective hyperthermic cancer cell destruction. In this case report, VV-PISH is studied for its safety and therapeutic efficiency in a Food and Drug Administration (FDA) approved phase-I study, where hyperthermia is used to treat advanced (Stage III B or IV) lung cancer. VV-PISH, utilizing the ThermoChem™ HT system in an extracorporeal circuit, was used to induce hyperthermia to 42.5°C sustained for 120 min. Cooling returned the body temperature to 37°C. After completion of the treatment, the patient was transferred to the intensive care unit on a ventilator, norepinephrine and diuretics. The patient remained somnolent for 36 h, developed pulmonary congestion requiring an additional 48 h before extubation, was transferred to the intermediate unit on day 4 and discharged in good condition on day 8. He did experience hyperthermia-related shrinkage of his lung cancer; however, he succumbed 270 days after this treatment from further progression of this disease. Hyperthermia is not a benign therapy; management techniques have been developed that have ameliorated many of the problems associated with extremely high temperatures, but pathophysiology still exists. Using these techniques, VV-PISH can be safety implemented, albeit not without temporary sequelae and further hospitalization.
9
Schwartz, A., D. Kaplan, V. Rosenzweig, M. Klein, B. F. Gruenbaum, S. E. Gruenbaum, M. Boyko, A. Zlotnik, and E. Brotfain. "The incidence of hyperthermia during cochlear implant surgery in children." Journal of Laryngology & Otology 131, no. 10 (August 15, 2017): 900–906. http://dx.doi.org/10.1017/s0022215117001682.
Full textAbstract:
AbstractBackground:Inadvertent hyperthermia during anaesthesia is a rare but life-threatening complication. We have encountered several cases of severe hyperthermia in paediatric patients undergoing anaesthesia for cochlear implantation.Methods:This study aimed to describe the clinical characteristics of children who developed hyperthermia while undergoing cochlear implantation, and to explore possible mechanisms and predisposing factors. The anaesthetic charts of all patients aged under 18 years who underwent cochlear implantation, or mastoid or ophthalmic surgery, between 1 January 2006 and 31 December 2009, at Soroka Medical Center in Beer Sheva, Israel, were reviewed. Patients undergoing mastoid and ophthalmic surgical procedures were used as controls.Results:A larger percentage of patients who underwent cochlear implant surgery (10 per cent) developed hyperthermia compared to controls (0.7 per cent, p < 0.05). In five of the seven cases, hyperthermia appeared in combination with tachycardia and hypercapnia, adhering to the clinical triad of malignant hyperthermia.Conclusion:Patients undergoing cochlear implantation are susceptible to developing intra-operative hyperthermia. This article describes the hyperthermic events that occur during paediatric cochlear implantation, and attempts to identify potential triggers of hyperthermia.
10
Zhou, Xun, Jamal Bouitbir, Matthias E. Liechti, Stephan Krähenbühl, and Riccardo V. Mancuso. "Hyperthermia Increases Neurotoxicity Associated with Novel Methcathinones." Cells 9, no. 4 (April 14, 2020): 965. http://dx.doi.org/10.3390/cells9040965.
Full textAbstract:
Hyperthermia is one of the severe acute adverse effects that can be caused by the ingestion of recreational drugs, such as methcathinones. The effect of hyperthermia on neurotoxicity is currently not known. The primary aim of our study was therefore to investigate the effects of hyperthermia (40.5 °C) on the neurotoxicity of methcathinone (MC), 4-chloromethcathinone (4-CMC), and 4-methylmethcathinone (4-MMC) in SH-SY5Y cells. We found that 4-CMC and 4-MMC were cytotoxic (decrease in cellular ATP and plasma membrane damage) under both hyper- (40.5 °C) and normothermic conditions (37 °C), whereby cells were more sensitive to the toxicants at 40.5 °C. 4-CMC and 4-MMC impaired the function of the mitochondrial electron transport chain and increased mitochondrial formation of reactive oxygen species (ROS) in SH-SY5Y cells, which were accentuated under hyperthermic conditions. Hyperthermia was associated with a rapid expression of the 70 kilodalton heat shock protein (Hsp70), which partially prevented cell death after 6 h of exposure to the toxicants. After 24 h of exposure, autophagy was stimulated by the toxicants and by hyperthermia but could only partially prevent cell death. In conclusion, hyperthermic conditions increased the neurotoxic properties of methcathinones despite the stimulation of protective mechanisms. These findings may be important for the understanding of the mechanisms and clinical consequences of the neurotoxicity associated with these compounds.
11
Jarboe, Tara, Danielle Quaranto, Nicole R. DeSouza, Kaci Kopec, Jan Geliebter, Raj K. Tiwari, and Mark D. Hurwitz. "Abstract 6643: Hyperthermic induction of immunotherapeutic response in in vitro melanoma model." Cancer Research 84, no. 6_Supplement (March 22, 2024): 6643. http://dx.doi.org/10.1158/1538-7445.am2024-6643.
Full textAbstract:
Abstract Immunotherapy has revolutionized the treatment of advanced melanoma, yet challenges persist with non-responders, development of resistance, and dosage concerns. Our strategy to enhance checkpoint inhibitor efficacy is to combine it with hyperthermia. Moderate hyperthermia, 39-45°C, is an interesting anti-neoplastic therapy which induces production of tumor associated antigens rendering tumor sites more amenable to immunotherapy. To investigate temperature-induced alterations on carcinogenic phenotypes in vitro, B16-F10 melanoma cells were grown at 37°C under normal culture conditions, or incubated at 41°C for 2 hours for moderate, febrile hyperthermic induction. Hyperthermia-induced changes were analyzed by trypan blue exclusion assay, scratch wound assay, collection of conditioned media for cytokine array, and protein isolation for Western Blot. Conditioned media from the hyperthermia-treated group showed an inflammatory shift in cytokine and chemokine expression, with increased TNFa and decreased IL-4 expression. Prior studies found the hyperthermia-induced apoptotic effect is directly correlated to endogenous TNFa levels, elucidating a potential molecular mechanism. Treatment for two hours at 41°C decreased proliferation of B16-F10 cells by 62% after 48 hours and 94% after 72 hours. Additionally, hyperthermia decreased cellular migration by 70% after 24 hours. Further evaluation of cellular interactions in important pathways responsible for these hyperthermia-induced changes were investigated via Western blot. Expression of constitutively active MAPK signaling cascade effectors pERK and ERK was decreased by 86% and 50%, respectively, helping to regulate pro-tumorigenic proliferative signaling. Some cancer cells have been demonstrated to resist hyperthermia via mechanisms to inhibit induction of caspase-3, however, in our model caspase-3 expression increased by 31% following 41°C treatment, thus allowing for induction of apoptosis via caspase-3 in this model. Cellular stress may induce these cell death pathways, as well as heat shock responses. Following febrile hyperthermic induction, hsp70 expression increased by 188% compared to cells cultured at 37°C. Hsp70 has a well-established role in supporting tumor-specific immune responses. Induction of hyperthermia in combination with anti-PDL1, anti-PD-1, or IL-15 immunotherapy is currently being evaluated in a C57BL/6 mouse model by our group. These studies aim to assess if hyperthermia augments response to immunotherapies in vivo. Our current works suggests that moderate, non-ablative hyperthermia helps initiate anti-tumor immune responses, assisting in the induction of anti-tumorigenic cell programs and, potentially, the production of additional tumor associated antigens, thereby making it an interesting candidate for combination with immune checkpoint inhibition and other immunotherapeutic approaches. Citation Format: Tara Jarboe, Danielle Quaranto, Nicole R. DeSouza, Kaci Kopec, Jan Geliebter, Raj K. Tiwari, Mark D. Hurwitz. Hyperthermic induction of immunotherapeutic response in in vitro melanoma model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6643.
12
Rajan, Govind, Robert Victor, Richard Kelly, Ryan Cockrill, Karen Katrivesis, and Corey Nelson. "A rare case of late onset malignant hyperthermia." Anaesthesia, Pain & Intensive Care 26, no. 4 (October 8, 2022): 546–50. http://dx.doi.org/10.35975/apic.v26i4.1963.
Full textAbstract:
A 42-year-old man with neck squamous cell carcinoma underwent awake fiberoptic intubation and tumor resection under general anesthesia. He developed malignant hyperthermia several hours into the surgical procedure. This case highlights malignant hyperthermia’s (MH) variable time course, pathognomonic signs, and the need for rapid diagnosis and treatment. Early recognition and treatment led to rapid resolution of MH. Ongoing discussion of MH is imperative because this disease is often difficult to diagnose early in its time course and may be fatal if not treated expeditiously.
Abbreviations: DS - Dantrolene sodium; DSIS - dantrolene sodium injectable suspension; GA - general anesthesia; MH - malignant hyperthermia; EtCO2 - end tidal carbon dioxide; RYR1 - Ryanodine Receptor gene
Key words: Anesthesia, General / methods; Dantrolene / therapeutic use; Diagnosis, Differential; Humans; Malignant Hyperthermia / diagnosis; Malignant Hyperthermia / etiology; Malignant Hyperthermia / physiopathology; Malignant Hyperthermia / therapy
Citation: Victor R, Kelly R, Cockrill R, Katrivesis K, Nelson C, Rajan G. A rare case of late onset malignant hyperthermia. Anaesth. pain intensive care. 2022;26(4):546-550; DOI: 10.35975/apic.v26i4.1963
Received: November 19, 2021; Reviewed: April 25, 2022; Accepted: July 12. 2022
13
Trychta, Kathleen A., and Brandon K. Harvey. "Caffeine and MDMA (Ecstasy) Exacerbate ER Stress Triggered by Hyperthermia." International Journal of Molecular Sciences 23, no. 4 (February 10, 2022): 1974. http://dx.doi.org/10.3390/ijms23041974.
Full textAbstract:
Drugs of abuse can cause local and systemic hyperthermia, a known trigger of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). Another trigger of ER stress and UPR is ER calcium depletion, which causes ER exodosis, the secretion of ER-resident proteins. In rodent models, club drugs such as 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) can create hyperthermic conditions in the brain and cause toxicity that is affected by the environmental temperature and the presence of other drugs, such as caffeine. In human studies, MDMA stimulated an acute, dose-dependent increase in core body temperature, but an examination of caffeine and MDMA in combination remains a topic for clinical research. Here we examine the secretion of ER-resident proteins and activation of the UPR under combined exposure to MDMA and caffeine in a cellular model of hyperthermia. We show that hyperthermia triggers the secretion of normally ER-resident proteins, and that this aberrant protein secretion is potentiated by the presence of MDMA, caffeine, or a combination of the two drugs. Hyperthermia activates the UPR but the addition of MDMA or caffeine does not alter the canonical UPR gene expression despite the drug effects on ER exodosis of UPR-related proteins. One exception was increased BiP/GRP78 mRNA levels in MDMA-treated cells exposed to hyperthermia. These findings suggest that club drug use under hyperthermic conditions exacerbates disruption of ER proteostasis, contributing to cellular toxicity.
14
Maduabuchi, Wisdom O., Felista L. Tansi, Regine Heller, and Ingrid Hilger. "Hyperthermia Influences the Secretion Signature of Tumor Cells and Affects Endothelial Cell Sprouting." Biomedicines 11, no. 8 (August 12, 2023): 2256. http://dx.doi.org/10.3390/biomedicines11082256.
Full textAbstract:
Tumors are a highly heterogeneous mass of tissue showing distinct therapy responses. In particular, the therapeutic outcome of tumor hyperthermia treatments has been inconsistent, presumably due to tumor versus endothelial cell cross-talks related to the treatment temperature and the tumor tissue environment. Here, we investigated the impact of the average or strong hyperthermic treatment (43 °C or 47 °C for 1 h) of the human pancreatic adenocarcinoma cell line (PANC-1 and BxPC-3) on endothelial cells (HUVECs) under post-treatment normoxic or hypoxic conditions. Immediately after the hyperthermia treatment, the distinct repression of secreted pro-angiogenic factors (e.g., VEGF, PDGF-AA, PDGF-BB, M-CSF), intracellular HIF-1α and the enhanced phosphorylation of ERK1/2 in tumor cells were detectable (particularly for strong hyperthermia, 2D cell monolayers). Notably, there was a significant increase in endothelial sprouting when 3D self-organized pancreatic cancer cells were treated with strong hyperthermia and the post-treatment conditions were hypoxic. Interestingly, for the used treatment temperatures, the intracellular HIF-1α accumulation in tumor cells seems to play a role in MAPK/ERK activation and mediator secretion (e.g., VEGF, PDGF-AA, Angiopoietin-2), as shown by inhibition experiments. Taken together, the hyperthermia of pancreatic adenocarcinoma cells in vitro impacts endothelial cells under defined environmental conditions (cell-to-cell contact, oxygen status, treatment temperature), whereby HIF-1α and VEGF secretion play a role in a complex context. Our observations could be exploited for the hyperthermic treatment of pancreatic cancer in the future.
15
Park, Robert I., and William J. Richtsmeier. "Hyperthermia Effects on the Growth of a Laryngeal Squamous Cell Carcinoma Cell Line Treated with Recombinant Human Interferons α and γ." Otolaryngology–Head and Neck Surgery 101, no. 5 (November 1989): 542–48. http://dx.doi.org/10.1177/019459988910100505.
Full textAbstract:
Clinical therapy with either interferon alpha or interferon gamma is associated with a febrile response. However, the effects of hyperthermia on the response to these interferons have not been elucidated fully. in this study, a cell line derived from a laryngeal squamous cell carcinoma (JHU-011-SCC-L-P) was grown in the presence of recombinant human interferon alpha (rHulFNα) or recombinant human Interferon gamma (rHulFNγ) and incubated at either 37° or 39° C, and cell growth rates were measured. Cells incubated with rHulFNα demonstrated no difference in growth rates from control cells. Cells treated with rHulFNγ showed significant inhibition of growth at both temperatures, and the ratio of decreased growth at 39° C was significantly greater than for the rHulFNα and control groups. This hyperthermic effect did not depend on the continued exposure to rHulFNγ, and the effect appeared to depend on the duration of hyperthermia instead of the time sequence of hyperthermic exposure. Moreover, initial treatment at 39° C for 24 hours was ineffective in producing the hyperthermic response produced with continuous hyperthermic exposure. These findings would indicate that the effect of rHulFNγ on this laryngeal squamous cell carcinoma cell line is enhanced significantly at 39° C compared with 37°C. There appears to be no similar hyperthermia-augmented antiproliferative effect of rHulFNα-treated cells.
16
Nybo, Lars, Bodil Nielsen, Eva Blomstrand, Kirsten Møller, and Niels Secher. "Neurohumoral responses during prolonged exercise in humans." Journal of Applied Physiology 95, no. 3 (September 2003): 1125–31. http://dx.doi.org/10.1152/japplphysiol.00241.2003.
Full textAbstract:
This study examined neurohumoral alterations during prolonged exercise with and without hyperthermia. The cerebral oxygen-to-carbohydrate uptake ratio (O2/CHO = arteriovenous oxygen difference divided by arteriovenous glucose difference plus one-half lactate), the cerebral balances of dopamine, and the metabolic precursor of serotonin, tryptophan, were evaluated in eight endurance-trained subjects during exercise randomized to be with or without hyperthermia. The core temperature stabilized at 37.9 ± 0.1°C (mean ± SE) in the control trial, whereas it increased to 39.7 ± 0.2°C in the hyperthermic trial, with a concomitant increase in perceived exertion ( P < 0.05). At rest, the brain had a small release of tryptophan (arteriovenous difference of -1.2 ± 0.3 μmol/l), whereas a net balance was obtained during the two exercise trials. Both the arterial and jugular venous dopamine levels became elevated during the hyperthermic trial, but the net release from the brain was unchanged. During exercise, the O2/CHO was similar across trials, but, during recovery from the hyperthermic trial, the ratio decreased to 3.8 ± 0.3 ( P < 0.05), whereas it returned to the baseline level of ∼6 within 5 min after the control trial. The lowering of O2/CHO was established by an increased arteriovenous glucose difference (1.1 ± 0.1 mmol/l during recovery from hyperthermia vs. 0.7 ± 0.1 mmol/l in control; P < 0.05). The present findings indicate that the brain has an increased need for carbohydrates during recovery from strenuous exercise, whereas enhanced perception of effort as observed during exercise with hyperthermia was not related to alterations in the cerebral balances of dopamine or tryptophan.
17
Kitagawa, Kazuo, Masayasu Matsumoto, Masafumi Tagaya, Keisuke Kuwabara, Ryuji Hata, Nobuo Handa, Ryuzo Fukunaga, Kazufumi Kimura, and Takenobu Kamada. "Hyperthermia-Induced Neuronal Protection against Ischemic Injury in Gerbils." Journal of Cerebral Blood Flow & Metabolism 11, no. 3 (May 1991): 449–52. http://dx.doi.org/10.1038/jcbfm.1991.86.
Full textAbstract:
We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemic neuronal death.
18
Siquier-Coll, Jesús, Juan Manuel Flores, Francisco Javier Grijota, Ignacio Bartolomé, Marcos Maynar-Mariño, and Víctor Toro-Román. "Acute Effect of Passive Hyperthermia on Lactate Concentrations." Applied Sciences 14, no. 7 (March 29, 2024): 2895. http://dx.doi.org/10.3390/app14072895.
Full textAbstract:
Background: Knowledge on the effect of heat on recovery is still incomplete. The present study aimed to evaluate the effect of a passive acute hyperthermic stimulus before and after a lactic anaerobic test on the production and oxidation of lactate blood concentrations. In addition, the purpose was to evaluate the effect that the application of this previous hyperthermic stimulus may have on the athletic performance in the test. Methods: For this purpose, a cross-over design through an anaerobic treadmill test in three different situations (normothermia, pre-test hyperthermia, and post-test hyperthermia) was performed. Twelve male subjects participated (age: 21.25 ± 1.64 years; height: 1.76 m ± 0.08; weight: 72.59 ± 9.44 kg). An anthropometric assessment was carried out with weight, height, skinfolds, body perimeters and diameters, and external and internal body temperatures in each of the tests. A nutritional survey was also carried out 48 h prior to each test. Results: The results of the study showed a decrease in blood lactate concentrations when the hyperthermic effect was applied as passive recovery just after the end of the test (p < 0.05). A decrease in lactate concentrations was also achieved when applying the hyperthermic effect just before the start of the test (p < 0.05). However, no significant improvements were obtained from this application of heat on test performance. Conclusions: The results suggest that the application of passive acute hyperthermia has a favourable effect in terms of decreasing blood lactate concentrations in a 5 min recovery period after lactic anaerobic activity.
19
Moriyama, Y., M. Narita, K. Sato, M. Urushiyama, S. Koyama, H. Hirosawa, K. Kishi, M. Takahashi, K. Takai, and A. Shibata. "Application of hyperthermia to the treatment of human acute leukemia: purging human leukemic progenitor cells by heat." Blood 67, no. 3 (March 1, 1986): 802–4. http://dx.doi.org/10.1182/blood.v67.3.802.802.
Full textAbstract:
Abstract The application of hyperthermia to the treatment of neoplastic disease has focused on solid tumors. Since the hyperthermic sensitivity of human acute leukemia cells is not known, we have studied the in vitro response of human leukemic progenitor cells (L-CFU) to hyperthermia using a quantitative assay system for L-CFU. Human L-CFU were found to be more sensitive than committed normal myeloid progenitor cells to hyperthermic killing (41 to 42 degrees C). In addition, in the five acute myelogenous leukemic patients studied, it was shown that their leukemic progenitor cells--all types were studied according to the French-American-British diagnosis--were unable to form colonies when exposed to a temperature of 42 degrees C for 60 minutes, whereas the residual normal clones suppressed by the leukemic cell population were found to recover and to form more colonies in vitro as compared with untreated leukemic marrows. This strongly suggests that in vitro hyperthermia may selectively purge residual leukemic cells, especially L-CFU in stored remission bone marrow before autologous bone marrow transplantation.
20
Moriyama, Y., M. Narita, K. Sato, M. Urushiyama, S. Koyama, H. Hirosawa, K. Kishi, M. Takahashi, K. Takai, and A. Shibata. "Application of hyperthermia to the treatment of human acute leukemia: purging human leukemic progenitor cells by heat." Blood 67, no. 3 (March 1, 1986): 802–4. http://dx.doi.org/10.1182/blood.v67.3.802.bloodjournal673802.
Full textAbstract:
The application of hyperthermia to the treatment of neoplastic disease has focused on solid tumors. Since the hyperthermic sensitivity of human acute leukemia cells is not known, we have studied the in vitro response of human leukemic progenitor cells (L-CFU) to hyperthermia using a quantitative assay system for L-CFU. Human L-CFU were found to be more sensitive than committed normal myeloid progenitor cells to hyperthermic killing (41 to 42 degrees C). In addition, in the five acute myelogenous leukemic patients studied, it was shown that their leukemic progenitor cells--all types were studied according to the French-American-British diagnosis--were unable to form colonies when exposed to a temperature of 42 degrees C for 60 minutes, whereas the residual normal clones suppressed by the leukemic cell population were found to recover and to form more colonies in vitro as compared with untreated leukemic marrows. This strongly suggests that in vitro hyperthermia may selectively purge residual leukemic cells, especially L-CFU in stored remission bone marrow before autologous bone marrow transplantation.
21
Zhang, Cuiwei, Shuiqin Li, and Ziyi Zhao. "β-Elemene Promotes Apoptosis Induced by Hyperthermia via Inhibiting HSP70." Disease Markers 2022 (July 19, 2022): 1–10. http://dx.doi.org/10.1155/2022/7313026.
Full textAbstract:
Thermotherapy has been presented as a promising strategy to be used as an effective nonsurgical technique for colorectal carcinoma. Although this strategy presents several advantages, including low toxicity and high repeatability, thermotherapy often needs to be combined with other therapies because residual tumor cells that survive hyperthermal treatment often lead to relapse. In this study, we evaluated the effects of β-elemene, which has been proven to have the potential to reverse chemotherapy drug resistance, on promoting the antitumor effects of hyperthermia. β-elemene treatment significantly promoted apoptosis after 2 hours of hyperthermia treatment and blocked cell cycle phases at G1/G0. β-elemene also significantly decreased colony formation and tumor formation abilities after hyperthermia treatment. β-elemene treatment significantly decreased HSP70, but not HSP90 or HSP27, induced by hyperthermia treatment without disturbing HSP70 mRNA. It was also found that β-elemene decreased phosphorylated ERK1/2 induced by hyperthermia. Regain of HSP70 reversed β-elemene-mediated apoptosis, indicating that β-elemene may induce apoptosis by decreasing HSP70. Moreover, β-elemene treatment significantly decreased invasion capacity by decreasing the EMT, which was induced by hyperthermia treatment. Taken together, our results offer a potential strategy for CRC therapy via the combination of hyperthermia and β-elemene.
22
Antanavičiūtė, Ieva, Vida Mildažienė, Edgaras Stankevičius, Thomas Herdegen, and Vytenis Arvydas Skeberdis. "Hyperthermia Differently Affects Connexin43 Expression and Gap Junction Permeability in Skeletal Myoblasts and HeLa Cells." Mediators of Inflammation 2014 (2014): 1–16. http://dx.doi.org/10.1155/2014/748290.
Full textAbstract:
Stress kinases can be activated by hyperthermia and modify the expression level and properties of membranous and intercellular channels. We examined the role of c-Jun NH2-terminal kinase (JNK) in hyperthermia-induced changes of connexin43 (Cx43) expression and permeability of Cx43 gap junctions (GJs) in the rabbit skeletal myoblasts (SkMs) and Cx43-EGFP transfected HeLa cells. Hyperthermia (42°C for 6 h) enhanced the activity of JNK and its target, the transcription factor c-Jun, in both SkMs and HeLa cells. In SkMs, hyperthermia caused a 3.2-fold increase in the total Cx43 protein level and enhanced the efficacy of GJ intercellular communication (GJIC). In striking contrast, hyperthermia reduced the total amount of Cx43 protein, the number of Cx43 channels in GJ plaques, the density of hemichannels in the cell membranes, and the efficiency of GJIC in HeLa cells. Both in SkMs and HeLa cells, these changes could be prevented by XG-102, a JNK inhibitor. In HeLa cells, the changes in Cx43 expression and GJIC under hyperthermic conditions were accompanied by JNK-dependent disorganization of actin cytoskeleton stress fibers while in SkMs, the actin cytoskeleton remained intact. These findings provide an attractive model to identify the regulatory players within signalosomes, which determine the cell-dependent outcomes of hyperthermia.
23
Gabriele, Pietro, Roberto Orecchia, Eugenia Madon, Maria Grazia Ruo Redda, and Gian Luca Sannazzari. "The Cost of Hypertermia: Nine Years Experience at the Radiation Therapy Department of the Turin University." Tumori Journal 80, no. 5 (October 1994): 327–31. http://dx.doi.org/10.1177/030089169408000502.
Full textAbstract:
Background In this paper the authors try to quantify the expenditure for the equipment, staff, treatment per patient and research, sustained at the Radiation Therapy Department of the University of Turin for the treatment of cancer with hyperthermia Methods Two hyperthermic computerized devices are available: the SAPIC SV03 multifrequencies system (915, 434 and 2-30 MHz) for external hyperthermia, and the SACEM system. working only with the frequency of 915 MHz, for interstitial and intracavitary heating. From September 1983 to December 1991, 408 patients have been treated with hyperthermia, for a total number of treated sites of 483; 2960 heating sessions were performed, with a average of six sessions per patient. Results The overall cost of our “hyperthermia project” was about 2,000,000,000 Italian liras; the equipment cost was estimated at 1,258,650,000 Liras (839,100 US$), and the cost per treatment and per heat session at about 3,985,200 (2676 US$) and 664,200 liras (443 US$), respectively. The cost of the research program can be estimated in 175,000,000 liras (116,666 US$). The National Health System provides for a partial reimbursement of 2,000,000 liras (1,333 US$) for each course of hyperthermia. Taking into account the mean expected life expectancy and increasing purchases for replacement of equipment, these costs increase 10% each year. As regards the cost-benefit problem, using the Rees formula it varies from 1112 US$ when hyperthermia is used as elective treatment to 3380 US$ when hyperthermia is used as palliative treatment. Conclusions Hyperthermia is, in our experience, an expensive therapy.
24
Tabatabaee, Fakhrosadat, Shahram Darabi, Reza Soltani, Fakhroddin Aghajanpour, Azar Afshar, Hojjat Allah Abbaszadeh, and Hassan Rajabi-Maham. "Therapeutic Effects of Exosome Therapy and Photobiomodulation Therapy on the Spermatogenesis Arrest in Male Mice After Scrotum Hyperthermia." Journal of Lasers in Medical Sciences 15 (March 3, 2024): e3. http://dx.doi.org/10.34172/jlms.2024.03.
Full textAbstract:
Introduction: In men, several factors cause infertility, among which we can mention damage to sperm due to high temperature. So far, various treatments have been proposed for it, but they have not been highly effective. The current study aimed to evaluate the effect of exosome therapy (EXO) and photobiomodulation therapy (PBMT) on spermatogenesis arrest in male mice after scrotum hyperthermia. Methods: In this experimental study, the animals were divided into four groups: control, scrotal hyperthermia, scrotal hyperthermia+EXO (100 μL/d) (mice were treated for 30 days), scrotal hyperthermia+PBMT (laser of 0.03 J/cm2 for 30 seconds/for 30 days). Hyperthermia was induced by exposure to the temperature of 43 °C for 20 minute every day for 5 times. After 6 weeks, the animals were sacrificed. Results: The treated groups showed a significant increase in sperm parameters, as compared to the hyperthermic groups. Moreover, these favorable effects were observed in relation to the volume of testicular tissue, the number of germ cells, Leydig cells and Sertoli cells, and the level of testosterone. Research on antioxidants showed a significant reduction in oxidized glutathione (GSSG) and reactive oxygen species (ROS) in the treatment groups in comparison to the hyperthermia group (P<0.001). Also, there has been a significant increase in the amount of hydrogen peroxide enzyme observed in the hyperthermia group as opposed to the treatment group (P<0.001). Conclusion: These findings show that EXO and PBMT can improve spermatogenesis caused by hyperthermia, reduce ROS and GSSG, and increase glutathione (GSH) and sperm quality.
25
Rafael, Stefanus Evan, Ah Yusuf, Hanik Endang Nihayati, and Aries Abiyoga. "Penerapan Evidence Based Nursing Tepid Sponge Bath dalam Menurunkan Suhu Tubuh Anak Demam." Journal of Telenursing (JOTING) 5, no. 2 (November 9, 2023): 2982–89. http://dx.doi.org/10.31539/joting.v5i2.5922.
Full textAbstract:
This study aims to analyze tepid sponge baths' effect in reducing hyperthermic children's body temperature. The research method used by Quasy is an experimental pre-test and post-test design. This study's results show a significant change in pre-measurements in respondents with hyperthermic body temperature. The criteria for achieving body temperature within normal limits with the tepid sponge bath intervention for 10-15 minutes, the post-test results show a decrease in the average body temperature of respondents from 38.5℃ to 36.5℃ in 10 respondents, the results criteria were achieved. In conclusion, providing tepid sponge bath therapy effectively reduces body temperature in children who experience problems treating hyperthermia.
Keywords: Hyperthermia, Childhood Concept, Increased Body Temperature, Tepid Sponge Bath
26
Zou, G.-Y., H. Shen, Y. Jiang, and X.-L. Zhang. "Synergistic Effect of a Novel Focal Hyperthermia on the Efficacy of Rifampin in Staphylococcal Experimental Foreign-Body Infection." Journal of International Medical Research 37, no. 4 (August 2009): 1115–26. http://dx.doi.org/10.1177/147323000903700416.
Full textAbstract:
This study was designed to evaluate the efficacy of focal hyperthermia and rifampin in vitro and in vivo using a rabbit model of foreign-body infection by methicillin-resistant Staphylococcus aureus (MRSA). In vitro studies demonstrated bacterial re-growth and development of rifampin resistance after 24 h with rifampin alone, which was prevented under hyperthermic conditions. For the in vivo studies, rifampin was administered intraperitoneally every 12 h for 7 days to rabbits with MRSA-containing cages implanted into their flanks. When combined with hyperthermia at 39°C, 41°C and 43°C, rifampin significantly reduced in-cage bacterial counts by > 3.0 log10 colony forming units/ml compared with rifampin alone. Eradication of cage-associated infection was achieved more effectively when rifampin was combined with hyperthermia, with cure rates of 70-95% on day 10. Focal hyperthermia combined with rifampin prevented the emergence of rifampin resistance and maintained rifampin efficacy. These findings might have implications for orthopaedic surgery.
27
Thompson, Ann M., and J. Gail Neely. "Induction of heat shock protein in interdental cells by hyperthermia." Otolaryngology–Head and Neck Surgery 107, no. 6_part_1 (December 1992): 769–74. http://dx.doi.org/10.1177/019459988910700611.1.
Full textAbstract:
The effect of hyperthermia on Induction of the 72 kllodalton (kDa) heat shock protein (HSP72) was examined In interdental cells of the guinea pig cochlea. After being Immersed in a water bath of either normal body temperature (37° C, control condition) or 43° C (hyperthermic condition), animals were killed either 0, 1, 2, 6, or 18 hours later. Cochlear sections were incubated with a monoclonal antibody raised against HSP72 and relative staining densities were quantified with a light microscopic image analysis system. Optical densities of the interdental cell region of animals receiving hyperthermia treatment were significantly greater than those of animals in the control group. Further analysis revealed that levels of HSP72 Immunoreactlvlty began increasing by 1 hour after hyperthermia and continued to increase thereafter, to reach maximal levels at 6 hours. The maximal levels were maintained for the rest of the experiment—18 hours. The results indicate that hyperthermia leads to an increase in the synthesis of HSP72 in guinea pig Interdental cells.
28
Panda, Pratikeswar. "Application of Hyperthermia for Cancer Treatment: Various Techniques and Recent Advancement." International Journal of Advanced Pharmaceutical Sciences and Research 4, no. 1 (December 30, 2023): 17–25. http://dx.doi.org/10.54105/ijapsr.a4035.124123.
Full textAbstract:
Cancer is a disease characterized by uncontrollable cell division in a specific area of the body. It is a leading cause of death, and its prevalence is increasing. There are numerous techniques and protocols employed, including as chemotherapy, radiography, surgical tumor removal, etc. However, these procedures have a number of negative side effects that cause excruciating pain and intense anxiety in the patients. It has been increasingly difficult to find new cancer-fighting strategies during the past few decades. One of the best cancer treatment choices is hyperthermia, an ancient form of therapy that offers fresh hope when paired with engineering methods. This study examines the crucial data for the coupling with hyperthermia of various engineering techniques, which is carefully organized according to the techniques used, such as hyperthermic perfusion, frequency enhancers, ultrasonic hyperthermia, external radio-frequency devices, microwave hyperthermia, using a catheter, heat the target area before injecting superparamagnetic and magnetic nanoparticles.
29
Tapper, Simon, Joseph J. Nocera, and Gary Burness. "Experimental evidence that hyperthermia limits offspring provisioning in a temperate-breeding bird." Royal Society Open Science 7, no. 10 (October 2020): 201589. http://dx.doi.org/10.1098/rsos.201589.
Full textAbstract:
In many vertebrates, parental care can require long bouts of daily exercise that can span several weeks. Exercise, especially in the heat, raises body temperature, and can lead to hyperthermia. Typical strategies for regulating body temperature during endurance exercise include modifying performance to avoid hyperthermia (anticipatory regulation) and allowing body temperature to rise above normothermic levels for brief periods of time (facultative hyperthermia). Facultative hyperthermia is commonly employed by desert birds to economize on water, but this strategy may also be important for chick-rearing birds to avoid reducing offspring provisioning when thermoregulatory demands are high. In this study, we tested how chick-rearing birds balance their own body temperature against the need to provision dependent offspring. We experimentally increased the heat dissipation capacity of breeding female tree swallows ( Tachycineta bicolor ) by trimming their ventral feathers and remotely monitored provisioning rates, body temperature and the probability of hyperthermia. Birds with an experimentally increased capacity to dissipate heat (i.e. trimmed treatment) maintained higher feeding rates than controls at high ambient temperatures (greater than or equal to 25°C), while maintaining lower body temperatures. However, at the highest temperatures (greater than or equal to 25°C), trimmed individuals became hyperthermic. These results provide evidence that chick-rearing tree swallows use both anticipatory regulation and facultative hyperthermia during endurance performance. With rising global temperatures, individuals may need to increase their frequency of facultative hyperthermia to maintain nestling provisioning, and thereby maximize reproductive success.
30
Schlader, Zachary J., Eric Rivas, Babs R. Soller, Victor A. Convertino, and Craig G. Crandall. "Tissue oxygen saturation during hyperthermic progressive central hypovolemia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 307, no. 6 (September 15, 2014): R731—R736. http://dx.doi.org/10.1152/ajpregu.00190.2014.
Full textAbstract:
During normothermia, a reduction in near-infrared spectroscopy (NIRS)-derived tissue oxygen saturation (So2) is an indicator of central hypovolemia. Hyperthermia increases skin blood flow and reduces tolerance to central hypovolemia, both of which may alter the interpretation of tissue So2 during central hypovolemia. This study tested the hypothesis that maximal reductions in tissue So2 would be similar throughout normothermic and hyperthermic central hypovolemia to presyncope. Ten healthy males (means ± SD; 32 ± 5 yr) underwent central hypovolemia via progressive lower-body negative pressure (LBNP) to presyncope during normothermia (skin temperature ≈34°C) and hyperthermia (+1.2 ± 0.1°C increase in internal temperature via a water-perfused suit, skin temperature ≈39°C). NIRS-derived forearm (flexor digitorum profundus) tissue So2 was measured throughout and analyzed as the absolute change from pre-LBNP. Hyperthermia reduced ( P < 0.001) LBNP tolerance by 49 ± 33% (from 16.7 ± 7.9 to 7.2 ± 3.9 min). Pre-LBNP, tissue So2 was similar ( P = 0.654) between normothermia (74 ± 5%) and hyperthermia (73 ± 7%). Tissue So2 decreased ( P < 0.001) throughout LBNP, but the reduction from pre-LBNP to presyncope was greater during normothermia (−10 ± 6%) than during hyperthermia (−6 ± 5%; P = 0.041). Contrary to our hypothesis, these findings indicate that hyperthermia is associated with a smaller maximal reduction in tissue So2 during central hypovolemia to presyncope.
31
Brophy, Hannah, Gaik Min Tan, and Charles William Yoxall. "Very Low Birth Weight Outcomes and Admission Temperature: Does Hyperthermia Matter?" Children 9, no. 11 (November 7, 2022): 1706. http://dx.doi.org/10.3390/children9111706.
Full textAbstract:
National and international recommendations for thermal care at preterm birth include recommendations to avoid hypothermia and hyperthermia. There is limited evidence demonstrating harm resulting from admission hyperthermia. Our aim was to assess the relationships between admission temperature and outcomes in very low birth weight (VLBW) babies in a unit with low rates of hypothermia and a higher rate of hyperthermia. This was an observational study based on routinely collected data including demographics, admission temperature, survival and major morbidity outcomes. Subjects were 1104 consecutive inborn VLBW babies admitted to a Neonatal Intensive Care Unit in United Kingdom between 2010 and 2017. Results: 155 (14%) of babies were hypothermic (<36.5 °C) with only 21 (1.9%) < 36 °C, and 254 (23%) of babies were hyperthermic (>37.5 °C). The rate of major abnormality on cranial ultrasound scan was increased in the hyperthermic babies compared to the normothermic babies (37/239 (15.5%) vs. 54/601 (9%), relative risk (95% CI) 1.723 (1.166 to 2.546), p = 0.006). There was no difference in survival or other major morbidity in the hyperthermic babies compared to the normothermic babies. There was no association between hypothermia and survival or any major morbidity, although this probably reflects the low power of the study given the low rates of significant hypothermia. Higher admission temperature was associated with an increase in the risk of major cranial ultrasound abnormality using multiple logistic regression analysis (p = 0.007) with an increased odds ratio (95% CI) of 1.48 (1.11 to 1.97) for each degree of increase. We conclude that admission hyperthermia is independently associated with an increased risk of preterm brain injury. It is not possible to state whether this is a causative association, or whether the association is a consequence of a shared aetiology of perinatal infection.
32
Ali, Adnan, and John J. Heikkila. "Enhanced accumulation of constitutive heat shock protein mRNA is an initial response of eye tissue to mild hyperthermia in vivo in adult Xenopus laevis." Canadian Journal of Physiology and Pharmacology 80, no. 11 (November 1, 2002): 1119–23. http://dx.doi.org/10.1139/y02-133.
Full textAbstract:
We have examined the effect of mild hyperthermia in vivo on heat shock transcription factor (HSF) binding activity and heat shock protein (hsp) gene expression in eye tissue of adult Xenopus laevis. A specific interaction between HSF and a synthetic oligonucleotide corresponding to the proximal heat shock element of the Xenopus hsp70B gene was greatly enhanced in eyes from hyperthermic animals compared with controls. Given these results, we examined the effect of hyperthermia in vivo on the expression of five hsp genes (hsp70, hsc70, BiP, hsp90, and hsp30) in eye tissue. Interestingly, at 28°C constitutively expressed hsp genes hsc70, BiP, and hsp90 were strongly enhanced, with further accumulation at 30°C. However, hsp70 and hsp30 mRNA accumulation were not detectable at 28°C but were strongly induced at 30°C. No enhancement of the relative levels of cytoskeletal actin mRNA was observed in the eye tissue of hyperthermic animals. These results suggest that one of the primary responses of eye tissue to hyperthermia in vivo is in the elevation of mRNAs encoding a set of constitutively expressed molecular chaperones.Key words: Xenopus, mRNA, eye, heat shock, heat shock factor.
33
Arcicasa, Mauro, Giovanni Franchin, Gabriella Bassignano, Giovanna Sartor, Annalisa Drigo, Roberto Bortolus, Mario Roncadin, Antonino De Paoli, and Mauro G. Trovò. "Hyperthermia in Clinical Practice: Preliminary Results and Current Problems in the Treatment of 21 Patients." Tumori Journal 78, no. 4 (August 1992): 262–65. http://dx.doi.org/10.1177/030089169207800410.
Full textAbstract:
From February 1988 through February 1991, 21 patients were managed by superficial hyperthermia and radiotherapy. Nineteen patients had received previous treatment; the most common histology was breast carcinoma. Twenty-six cycles of combined hyperthermia and radiotherapy were delivered: 4 complete responses (15.4 %), 17 partial responses (65.4 %), 1 minimal partial response (3.8 %), 3 stable diseases (11.6 %) and 1 disease progression (3.8 %) were obtained. The median duration of response was 7 months (range 1-16) for responding and 4 months (range 2.5-4) for non-responding patients. The toxicity encountered (confined mostly to epithelitis –- 7/21 patients) was completely reversible. In our experience, hyperthermia combined with radiotherapy proved to be an effective treatment. However, some problem that emerged during treatment planning and delivery showed the need for further development and research into hyperthermic devices and thermometry systems.
34
Nybo, Lars, Kirsten Møller, Stefanos Volianitis, Bodil Nielsen, and Niels H. Secher. "Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans." Journal of Applied Physiology 93, no. 1 (July 1, 2002): 58–64. http://dx.doi.org/10.1152/japplphysiol.00049.2002.
Full textAbstract:
The development of hyperthermia during prolonged exercise in humans is associated with various changes in the brain, but it is not known whether the cerebral metabolism or the global cerebral blood flow (gCBF) is affected. Eight endurance-trained subjects completed two exercise bouts on a cycle ergometer. The gCBF and cerebral metabolic rates of oxygen, glucose, and lactate were determined with the Kety-Schmidt technique after 15 min of exercise when core temperature was similar across trials, and at the end of exercise, either when subjects remained normothermic (core temperature = 37.9°C; control) or when severe hyperthermia had developed (core temperature = 39.5°C; hyperthermia). The gCBF was similar after 15 min in the two trials, and it remained stable throughout control. In contrast, during hyperthermia gCBF decreased by 18% and was therefore lower in hyperthermia compared with control at the end of exercise (43 ± 4 vs. 51 ± 4 ml · 100 g−1· min−1; P < 0.05). Concomitant with the reduction in gCBF, there was a proportionally larger increase in the arteriovenous differences for oxygen and glucose, and the cerebral metabolic rate was therefore higher at the end of the hyperthermic trial compared with control. The hyperthermia-induced lowering of gCBF did not alter cerebral lactate release. The hyperthermia-induced reduction in exercise cerebral blood flow seems to relate to a concomitant 18% lowering of arterial carbon dioxide tension, whereas the higher cerebral metabolic rate of oxygen may be ascribed to a Q10(temperature) effect and/or the level of cerebral neuronal activity associated with increased exertion.
35
Scutigliani, Enzo M., Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, et al. "Evaluation of the Heat Shock Protein 90 Inhibitor Ganetespib as a Sensitizer to Hyperthermia-Based Cancer Treatments." Cancers 14, no. 21 (October 26, 2022): 5250. http://dx.doi.org/10.3390/cancers14215250.
Full textAbstract:
Hyperthermia is being used as a radio- and chemotherapy sensitizer for a growing range of tumor subtypes in the clinic. Its potential is limited, however, by the ability of cancer cells to activate a protective mechanism known as the heat stress response (HSR). The HSR is marked by the rapid overexpression of molecular chaperones, and recent advances in drug development make their inhibition an attractive option to improve the efficacy of hyperthermia-based therapies. Our previous in vitro work showed that a single, short co-treatment with a HSR (HSP90) inhibitor ganetespib prolongs and potentiates the effects of hyperthermia on DNA repair, enhances hyperthermic sensitization to radio- and chemotherapeutic agents, and reduces thermotolerance. In the current study, we first validated these results using an extended panel of cell lines and more robust methodology. Next, we examined the effects of hyperthermia and ganetespib on global proteome changes. Finally, we evaluated the potential of ganetespib to boost the efficacy of thermo-chemotherapy and thermo-radiotherapy in a xenograft murine model of cervix cancer. Our results revealed new insights into the effects of HSR inhibition on cellular responses to heat and show that ganetespib could be employed to increase the efficacy of hyperthermia when combined with radiation.
36
Caldwell, Aaron R., Jenna Burchfield, Nicole E. Moyen, Matthew A. Tucker, Cory L. Butts, R. J. Elbin, and Matthew S. Ganio. "Obesity, but not hypohydration, mediates changes in mental task load during passive heating in females." PeerJ 6 (August 16, 2018): e5394. http://dx.doi.org/10.7717/peerj.5394.
Full textAbstract:
BackgroundThe independent effects of hypohydration and hyperthermia on cognition and mood is unclear since the two stresses often confound each other. Further, it is unknown if obese individuals have the same impairments during hyperthermia and hypohydration that is often observed in non-obese individuals.MethodsThe current study was designed to assess the independent and combined effects of mild hypohydration and hyperthermia on cognition, mood, and mental task load in obese and non-obese females. Twenty-one healthy females participated in two passive heating trials, wherein they were either euhydrated or hypohydrated prior to and throughout passive heating. Cognition (ImPACT), mental task load (NASA-TLX), and mood (Brunel Mood Scale; BRUMS) were measured before and after a 1.0 °C increase in core temperature (TC).ResultsAfter a 1.0 °C TCelevation, hypohydration resulted in greater (p < 0.05) body mass loss (−1.14 ± 0.48 vs −0.58 ± 0.48 kg; hypohydrated and euhydrated, respectively) and elevation in serum osmolality (292 ± 4 vs 282 ± 3 mOsm;p < 0.05) versus euhydration. Hypohydration, independent of hyperthermia, did not affect mental task load or mood (p > 0.05). Hyperthermia, regardless of hydration status, impaired (∼5 A.U) measures of memory-based cognition (verbal and visual memory), and increased mental task load, while worsening mood (p < 0.05). Interestingly, obese individuals had increased mental task load while hyperthermic compared to the non-obese individuals (p < 0.05) even while euhydrated. Hypohydration did not exacerbate any heat-related effects on cognition between obese and non-obese females (p > 0.05).ConclusionThese data indicate that hyperthermia independently impairs memory-based aspects of cognitive performance, mental task load, and leads to a negative mood state. Mild hypohydration did not exacerbate the effects of hyperthermia. However, obese individuals had increased mental task load during hyperthermia.
37
Yusri, Rahmawati, and Muldarisnur Muldarisnur. "Application of Complementary Split Ring Resonator for Hyperthermia." JURNAL ILMU FISIKA | UNIVERSITAS ANDALAS 13, no. 1 (February 28, 2021): 34–40. http://dx.doi.org/10.25077/jif.13.1.34-40.2021.
Full textAbstract:
One of the most promising research for cancer therapy with less side effects is hyperthermia treatment using metamaterial. This treatment may stand independently or adjunct to other cancer treatments such as chemotherapy, radiotherapy, and others. Metamaterial may control the heating process needed and also the depth of metamaterial itself from the skin surface. In this simulation, complementary split-ring resonator (cSRR) metamaterial with gaps from 0.5 to 3.5 mm can be used for the hyperthermia treatment. In the simulation of the cSRR metamaterial as hyperthermia therapy for cancer cells, the heat generated from each cSRR model was not significantly different. All cSRR models can reach hyperthermal temperatures under 5 minutes. The highest temperature achievement after 60 minutes can be seen in the use of single gap cSRR (58.9 ℃), dual gaps cSRR (58.1 oC), triple gaps cSRR (57.5 ℃), and quad gaps cSRR (57.2 ℃). The cSRR metamaterial structure can be used for hyperthermia therapy by adjusting the treatment duration treatment on cancer cells.
38
Takagi, K., M. D. Ginsberg, M. Y. Globus, E. Martinez, and R. Busto. "Effect of hyperthermia on glutamate release in ischemic penumbra after middle cerebral artery occlusion in rats." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 5 (November 1, 1994): H1770—H1776. http://dx.doi.org/10.1152/ajpheart.1994.267.5.h1770.
Full textAbstract:
Using microdialysis, we investigated the effect of hyperthermia on glutamate release in penumbral cortex of rats with 2 h of either normothermic (37 degrees C) or hyperthermic (39 degrees C) middle cerebral artery (MCA) occlusion. Penumbral blood flow (CBF) was measured by laser-Doppler flowmetry. CBF values (expressed as % preischemic values) in normothermic and hyperthermic groups were 24 +/- 11 (SD) and 24 +/- 16%, respectively, during ischemia and 102 +/- 81 and 147 +/- 79% during recirculation. Average extracellular glutamate in the hyperthermic group increased from a baseline of 7 +/- 2 microM to a peak of 217 +/- 184 microM at 10-20 min after onset of ischemia but returned to near baseline after 60 min. Glutamate in the normothermic group increased from 4 +/- 2 microM to a peak of 26 +/- 17 microM at 10-20 min after MCA occlusion but fell to near-baseline before recirculation. Thus reuptake systems appeared to remain functional in ischemic penumbra, even during hyperthermia. Ischemic glutamate release was significantly higher in hyperthermic than in normothermic rats: average values of individual rats' peak levels were 251 +/- 221 microM and 37 +/- 34 microM, respectively. The ischemic CBF threshold value for glutamate release was 33% of control in the normothermic group but 61% in the hyperthermic group.
39
Lismayanti, Lilis, Andika Abdul Malik, Nida Siti Padilah, Fidya Anisa Firdaus, and Henri Setiawan. "Warm Compress on Lowering Body Temperature Among Hyperthermia Patients: A Literature Review." International Journal of Nursing and Health Services (IJNHS) 4, no. 3 (November 23, 2021): 344–55. http://dx.doi.org/10.35654/ijnhs.v4i3.465.
Full textAbstract:
Hyperthermia increased the core human body temperature above normal 36.7-37.5 °C, usually caused by infection, resulting in fever, and was the most common manifestation. One of the efforts that could be done to overcome the symptoms of hyperthermia was the application of warm compresses to the frontal, axillary, and dorsalis pedis. The study aimed to describe body temperature changes in hyperthermic patients after warm compress was applied. This study used a descriptive design with a literature review approach. Twelve articles were included in this review by six journal databases: PubMed, JSTOR, Wiley Online Library, Sage Journal, Taylor and Francis Online, and Google Scholar. The selection was carried out by assessing articles that met the inclusion criteria, including the publication range for 2008-2021, English and Indonesian languages ??, and open access to full-text pdf. The critical assessment was carried out by using the Critical Appraisal Skills Programmed instrument. The review results showed that the warm compress method had a positive effect in lowering body temperature in the nursing process in patients with hyperthermia. Based on the literature from the reviewed articles, it could be concluded that a warm compress intervention needed to be given to hyperthermic patients to lower the patient's body temperature whether they were undergoing treatment or not
40
Curtis, Andrew N., Michael L. Walsh, and Matthew D. White. "Influence of passive hyperthermia on human ventilation during rest and isocapnic hypoxia." Applied Physiology, Nutrition, and Metabolism 32, no. 4 (August 2007): 721–32. http://dx.doi.org/10.1139/h07-035.
Full textAbstract:
The purpose of this study was to examine the potential interaction of core temperature and isocapnic hypoxia on human ventilation and heart rate (HR). In 2 resting head-out water-immersion trials, 8 males first breathed air and then 12% O2 in N2 while the end-tidal partial pressure of carbon dioxide was kept 0.98 (0.66) mmHg (mean (SD)) above normothermic resting levels. The first immersion trial was with a normothermic esophageal temperature (Tes) of ~36.7 °C, and for the second trial, 1 h later, water temperature was increased to give a hyperthermic Tes of ~38.2 °C. Isocapnic hypoxia increased normothermic ventilation by 4 L·min–1 (p = 0.01) from 10.12 (1.07) to 14.20 (3.21) L·min–1, and hyperthermic ventiliation by 7 L·min–1 (p = 0.002) from 13.58 (2.58) to 20.79 (3.73) L·min–1. Ventilation increases during hyperthermia were mediated by breathing frequency and, during isocapnic hypoxia, by tidal volume. Unexpectedly, there was an absence of any hypoxic ventilatory decline that could be attributed to a hydrostatic effect of immersion. Isocapnic hypoxia increased the HR by similar amounts of ~10 and ~11 beats·min–1 in normothermia and hyperthermia, respectively. In conclusion, it appears that hyperthermia increases human ventilatory but not heart rate responses to isocapnic hypoxia.
41
Demirel, Haydar A., Karyn L. Hamilton, R. Andrew Shanely, Nihal Tümer, Mary Jo Koroly, and Scott K. Powers. "Age and attenuation of exercise-induced myocardial HSP72 accumulation." American Journal of Physiology-Heart and Circulatory Physiology 285, no. 4 (October 2003): H1609—H1615. http://dx.doi.org/10.1152/ajpheart.00982.2002.
Full textAbstract:
Overexpression of heat shock protein (HSP)72 is associated with cardioprotection. Hyperthermia-induced HSP72 overexpression is attenuated with senescence. While exercise also increases myocardial HSP72 in young animals, it is unknown whether this effect is attenuated with aging. Therefore, we investigated the effect of aging on exercise-induced myocardial heat shock factor (HSF)-1 activation and HSP72 expression. Male Fischer-344 rats (6 or 24 mo) were randomized to control, exercise, and hyperthermic groups. Exercise consisted of 2 days of treadmill running (60 min/day, ∼75% maximal oxygen consumption). Hyperthermia, 15 min at ∼41°C (colonic temperature), was achieved using a temperature-controlled heating blanket. Analyses included Western blotting for myocardial HSP72 and HSF-1, electromobility shift assays for HSF-1 activation, and Northern blotting for HSP72 mRNA. Exercise and hyperthermia increased ( P < 0.05) myocardial HSP72 in both young (>3.5- and 2.5-fold, respectively) and aged (>3- and 1.5-fold, respectively) animals. Both exercise and hyperthermic induction of HSP72 was attenuated with age. Myocardial HSF-1 protein, HSF-1 activation, and HSP72 mRNA did not differ with age. These data demonstrate that aging is associated with diminished exercise-induced myocardial HSP72 expression. Mechanisms other than HSF-1 activation and transcription of HSP72 mRNA are responsible for this age-related impairment.
42
Naučienė, Zita, Rasa Žūkienė, Laima Degutytė-Fomins, and Vida Mildažienė. "Mitochondrial Membrane Barrier Function as a Target of Hyperthermia." Medicina 48, no. 5 (June 5, 2012): 36. http://dx.doi.org/10.3390/medicina48050036.
Full textAbstract:
Background and Objective. Hyperthermia is a promising modality for cancer treatment that urgently requires detailed knowledge on molecular and cellular processes for the rational development of treatment protocols. The thorough study of the response of the inner membrane of heart and liver mitochondria to hyperthermia was performed in order to establish the pattern of the hyperthermia-induced changes in the membrane barrier function. Material and Methods. The isolated mitochondria from rat heart and liver (of both genders) were used for experiments, as well as mitochondria isolated from the perfused male rat liver. Changes in the membrane permeability were evaluated by mitochondrial respiration in state 2 or by estimation of the modular kinetics of the membrane leak. Results. The inner membrane of isolated mitochondria from healthy tissues was found to be an extremely sensitive target of hyperthermia that exerted the response even in the febrile range. More severe hyperthermia compromised the inner mitochondrial membrane function; however, this response was tissue-specific and, to some extent, gender-dependent (for liver mitochondria). The data obtained by direct heating of isolated mitochondria were validated by experiments on the perfused liver. Conclusions. The obtained results imply a crucial importance of the evaluation of the tissue- and gender-specific differences while developing or improving the protocols for hyperthermic treatment or combinatory therapy.
43
Atkins, Coleen M., Helen M. Bramlett, and W. Dalton Dietrich. "Is temperature an important variable in recovery after mild traumatic brain injury?" F1000Research 6 (November 20, 2017): 2031. http://dx.doi.org/10.12688/f1000research.12025.1.
Full textAbstract:
With nearly 42 million mild traumatic brain injuries (mTBIs) occurring worldwide every year, understanding the factors that may adversely influence recovery after mTBI is important for developing guidelines in mTBI management. Extensive clinical evidence exists documenting the detrimental effects of elevated temperature levels on recovery after moderate to severe TBI. However, whether elevated temperature alters recovery after mTBI or concussion is an active area of investigation. Individuals engaged in exercise and competitive sports regularly experience body and brain temperature increases to hyperthermic levels and these temperature increases are prolonged in hot and humid ambient environments. Thus, there is a strong potential for hyperthermia to alter recovery after mTBI in a subset of individuals at risk for mTBI. Preclinical mTBI studies have found that elevating brain temperature to 39°C before mTBI significantly increases neuronal death within the cortex and hippocampus and also worsens cognitive deficits. This review summarizes the pathology and behavioral problems of mTBI that are exacerbated by hyperthermia and discusses whether hyperthermia is a variable that should be considered after concussion and mTBI. Finally, underlying pathophysiological mechanisms responsible for hyperthermia-induced altered responses to mTBI and potential gender considerations are discussed.
44
Kuroiwa, Toshihiko, Petra Bonnekoh, and Konstantin-Alexander Hossmann. "Prevention of Postischemic Hyperthermia Prevents Ischemic Injury of CA1 Neurons in Gerbils." Journal of Cerebral Blood Flow & Metabolism 10, no. 4 (July 1990): 550–56. http://dx.doi.org/10.1038/jcbfm.1990.97.
Full textAbstract:
Halothane-anesthetized Mongolian gerbils were submitted to 5-min bilateral carotid artery occlusion. After ischemia, halothane anesthesia was continued for various periods of up to 85 min, and the degree of CA1 neuronal injury was estimated 7 days later by counting the number of surviving pyramidal cells. During ischemia and postischemic halothane anesthesia, rectal and cranial temperature was kept at control level (37.7 and 37.0°C, respectively) using a feedback-controlled heating system. When anesthesia was discontinued after ischemia, transient hyperthermia occurred. In animals with 0- and 15-min postischemic halothane anesthesia, both cranial and rectal temperature rose by ∼1.5°C, and the number of surviving CA1 neurons amounted to <25% of control. After 45- or 85-min postischemic anesthesia, hyperthermia was significantly reduced and the number of surviving neurons increased to 65 and 89%, respectively. The protective effect of postischemic anesthesia was lost when anesthetized animals were submitted to the same hyperthermic profile as nonanesthetized ones, using a feedback-controlled heating system (16% surviving neurons in hyperthermia vs. 89% in normothermia, respectively). These observations demonstrate that postischemic anesthesia with 1% halothane protects against delayed neuronal death by preventing postischemic hyperthermia and not by its anesthetic effects.
45
Shecterle, L. M., N. Wetherall, and J. A. St. Cyr. "Effects on C3 and CH50 Levels During and Following Extracorporeal Whole Body Hyperthermia." Journal of ExtraCorporeal Technology 31, no. 4 (December 1999): 191–94. http://dx.doi.org/10.1051/ject/1999314191.
Full textAbstract:
Cardiopulmonary bypass can affect inflammatory reactions and evoke the “postperfusion syndrome,” manifested as multiple organ dysfunction in the recovery period. This syndrome is generated by the activation of complement, macrophages, neutrophils, and inflammatory cytokines. Following the use of hypothermia during cardiac procedures, active hyperthermic rewarming is used to reestablish body temperature. Complement levels and their interactions have been investigated during and following hypothermia. Hyperthermia is being used clinically; however, the effect of markedly elevated temperatures on complement is unknown and, therefore, needs to be investigated. A pilot canine study was designed to begin to explore what role hyperthermia may play on complement levels during and following extracorporeal whole body hyperthermia. Five dogs were heated to a core temperature of approximately 42°C, held at this elevated temperature for 90 minutes, then cooled to normothermia. A decline in C3 levels at the end of warming with further declines through day 4 post treatment was observed. CH50 levels mimicked the C3 level decline; however, there was a trend for rebounding by day 4. The findings involving complement factors following hyperthermia signify that this increase in temperature causes a decrease in both C3 and CH50 levels.
46
Nybo, Lars, and Bodil Nielsen. "Hyperthermia and central fatigue during prolonged exercise in humans." Journal of Applied Physiology 91, no. 3 (September 1, 2001): 1055–60. http://dx.doi.org/10.1152/jappl.2001.91.3.1055.
Full textAbstract:
The present study investigated the effects of hyperthermia on the contributions of central and peripheral factors to the development of neuromuscular fatigue. Fourteen men exercised at 60% maximal oxygen consumption on a cycle ergometer in hot (40°C; hyperthermia) and thermoneutral (18°C; control) environments. In hyperthermia, the core temperature increased throughout the exercise period and reached a peak value of 40.0 ± 0.1°C (mean ± SE) at exhaustion after 50 ± 3 min of exercise. In control, core temperature stabilized at ∼38.0 ± 0.1°C, and exercise was maintained for 1 h without exhausting the subjects. Immediately after the cycle trials, subjects performed 2 min of sustained maximal voluntary contraction (MVC) either with the exercised legs (knee extension) or with a “nonexercised” muscle group (handgrip). The degree of voluntary activation during sustained maximal knee extensions was assessed by superimposing electrical stimulation (EL) to nervus femoralis. Voluntary knee extensor force was similar during the first 5 s of contraction in hyperthermia and control. Thereafter, force declined in both trials, but the reduction in maximal voluntary force was more pronounced in the hyperthermic trial, and, from 30 to 120 s, the force was significantly lower in hyperthermia compared with control. Calculation of the voluntary activation percentage (MVC/MVC + EL) revealed that the degree of central activation was significantly lower in hyperthermia (54 ± 7%) compared with control (82 ± 6%). In contrast, total force of the knee extensors (MVC + force from EL) was not different in the two trials. Force development during handgrip contraction followed the same pattern of response as was observed for the knee extensors. In conclusion, these data demonstrate that the ability to generate force during a prolonged MVC is attenuated with hyperthermia, and the impaired performance is associated with a reduction in the voluntary activation percentage.
47
White, Matthew D. "Components and mechanisms of thermal hyperpnea." Journal of Applied Physiology 101, no. 2 (August 2006): 655–63. http://dx.doi.org/10.1152/japplphysiol.00210.2006.
Full textAbstract:
The pattern of breathing during a hyperthermia-induced hyperventilation varies across different species. Thermal tachypnea is a first phase panting response adopted during hyperthermia when tidal volume is minimized and the frequency of breathing is maximized. Blood-gas tensions and pH are maintained during this hyperventilation, and the associated heat loss helps the animal regulate its body temperature. A second pattern of breathing adopted in hyperthermia is thermal hyperpnea; this response is the focus of this review. This form of hyperventilation is evident after an increase in core temperature and it is apparent in humans. Increases of tidal volume as well as frequency of breathing are evident during this response that results in a respiratory alkalosis. The cause of thermal hyperpnea is not resolved; evidence of the potential mechanisms underlying this response support that modulators of the response act in either a multiplicative or additive manner with body temperatures. The details of the designs and methodologies of the studies supporting or refuting these two views are discussed. A physiological rationale for thermal hyperpnea is presented in which it is suggested this response serves a heat-loss role and contributes to selective brain cooling in hyperthermic humans. Ongoing research in this area is focused on resolving the mechanisms underlying thermal hyperpnea and its contribution to cranial thermoregulation. The direct application of this research is for the care of febrile and hyperthermic patients.
48
Ni, Dan, and Lu-Yuan Lee. "Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons." American Journal of Physiology-Lung Cellular and Molecular Physiology 294, no. 3 (March 2008): L563—L571. http://dx.doi.org/10.1152/ajplung.00336.2007.
Full textAbstract:
Hyperthermia has been shown to sensitize vagal pulmonary C-fibers in anesthetized rats. However, it was not clear whether the effect was due to a direct action of hyperthermia on these sensory neurons. To answer this question, we carried out this study to determine the effect of increasing temperature on the responses to various chemical stimuli in isolated nodose and jugular ganglion neurons innervating the rat lungs. In the whole cell perforated patch-clamp study, when the temperature was increased from normal (∼36°C) to hyperthermic (∼40.6°C) level of the rat body temperature, the inward currents evoked by capsaicin, a selective activator of the transient receptor potential vanilloid type 1 (TRPV1), and 2-aminoethoxydiphenyl borate (2-APB), a nonselective activator of TRPV1–3 receptors, were both significantly increased. This potentiating effect was clearly present even at a moderate level of hyperthermia (∼39°C). However, only the slow, sustained component of acid-evoked current mediated through the TRPV1 receptor was potentiated by hyperthermia, whereas the rapid, transient component was inhibited. In contrast, the currents evoked by adenosine 5′-triphosphate and acetylcholine, neither of which is known to activate the TRPV1 channel, did not increase when the same temperature elevation was applied. Furthermore, the hyperthermia-induced potentiation of the cell response to 2-APB was significantly attenuated by either capsazepine or AMG 9810, selective TRPV1 antagonists. In conclusion, increasing temperature within the physiological range exerts a potentiating effect on the response to TRPV1 activators in these neurons, which is probably mediated through a positive interaction between hyperthermia and these chemical activators at the TRPV1 channel.
49
Verhulst, Johanna. "Hyperthermic intraperitoneal chemoperfusion with high dose oxaliplatin: Influence of perfusion temperature on postoperative outcome and survival." F1000Research 2 (September 3, 2013): 179. http://dx.doi.org/10.12688/f1000research.2-179.v1.
Full textAbstract:
Introduction: Hyperthermic intraperitoneal chemotherapy (HIPEC) is becoming a standard therapy in the treatment of peritoneal carcinomatosis (PC). Compared to systemic chemotherapy, HIPEC improves survival in patients with PC. This therapy has high morbidity rates (up to 41%). In vitro it has been demonstrated that hyperthermia has a toxic effect on malign cells. However, hyperthermia also affects normal tissue. To my knowledge, any additional effect of hyperthermia combined with chemotherapy has never been demonstrated in a clinical setting. In this study, the effects of hyperthermia on outcome and survival were analyzed.Methods: Patients with PC from any origin who were treated with HIPEC were included in this retrospective, non-randomized study. Data on patient characteristics, tumor characteristics, features of the surgery and postoperative complications were extracted from patient files. Models predicting time to removal of nasogastric tube (TRNT), post-operative major complications, the occurrence of anastomotic leaks and post-operative survival were built, using negative binomial regression, logistic regression or Cox proportional hazards regression as appropriate.Results: 138 patients treated with HIPEC were included. Maximal temperature during the operation was not statistically significantly associated with anastomotic leaks or post-operative major complications. Maximal temperature during the operation was negatively associated with post-operative survival (P=0.01).Conclusion: The results suggest that hyperthermia may negatively affect survival in patients who are treated with HIPEC for PC of various origins. This study has the classical limitations of a retrospective study. Therefore, randomized trials are required to confirm the results.
50
Verhulst, Johanna. "Hyperthermic intraperitoneal chemoperfusion with high dose oxaliplatin: Influence of perfusion temperature on postoperative outcome and survival." F1000Research 2 (October 16, 2015): 179. http://dx.doi.org/10.12688/f1000research.2-179.v2.
Full textAbstract:
Introduction: Hyperthermic intraperitoneal chemotherapy (HIPEC) is becoming a standard therapy in the treatment of peritoneal carcinomatosis (PC). Compared to systemic chemotherapy, HIPEC improves survival in patients with PC. This therapy has high morbidity rates (up to 41%). In vitro it has been demonstrated that hyperthermia has a toxic effect on malign cells. However, hyperthermia also affects normal tissue. To my knowledge, any additional effect of hyperthermia combined with chemotherapy has never been demonstrated in a clinical setting. In this study, the effects of hyperthermia on outcome and survival were analyzed. Methods: Patients with PC from any origin who were treated with HIPEC were included in this retrospective, non-randomized study. Data on patient characteristics, tumor characteristics, features of the surgery and postoperative complications were extracted from patient files. Models predicting time to removal of nasogastric tube (TRNT), post-operative major complications, the occurrence of anastomotic leaks and post-operative survival were built, using negative binomial regression, logistic regression or Cox proportional hazards regression as appropriate. Results: 138 patients treated with HIPEC were included. Maximal temperature during the operation was not statistically significantly associated with anastomotic leaks or post-operative major complications. Maximal temperature during the operation was negatively associated with post-operative survival (P=0.01). Conclusion: The results suggest that hyperthermia may negatively affect survival in patients who are treated with HIPEC for PC of various origins. This study has the classical limitations of a retrospective study. Therefore, randomized trials are required to confirm the results.