Relevant bibliographies by topics / Hyperthermia

Academic literature on the topic 'Hyperthermia'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 May 2024

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Journal articles on the topic "Hyperthermia"

1

Schlader, Zachary J., Thomas Seifert, Thad E. Wilson, Morten Bundgaard-Nielsen, Niels H. Secher, and Craig G. Crandall. "Acute volume expansion attenuates hyperthermia-induced reductions in cerebral perfusion during simulated hemorrhage." Journal of Applied Physiology 114, no. 12 (June 15, 2013): 1730–35. http://dx.doi.org/10.1152/japplphysiol.00079.2013.

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Hyperthermia reduces the capacity to withstand a simulated hemorrhagic challenge, but volume loading preserves this capacity. This study tested the hypotheses that acute volume expansion during hyperthermia increases cerebral perfusion and attenuates reductions in cerebral perfusion during a simulated hemorrhagic challenge induced by lower-body negative pressure (LBNP). Eight healthy young male subjects underwent a supine baseline period (pre-LBNP), followed by 15- and 30-mmHg LBNP while normothermic, hyperthermic (increased pulmonary artery blood temperature ∼1.1°C), and following acute volume infusion while hyperthermic. Primary dependent variables were mean middle cerebral artery blood velocity (MCAvmean), serving as an index of cerebral perfusion; mean arterial pressure (MAP); and cardiac output (thermodilution). During baseline, hyperthermia reduced MCAvmean ( P = 0.001) by 12 ± 9% relative to normothermia. Volume infusion while hyperthermic increased cardiac output by 2.8 ± 1.4 l/min ( P < 0.001), but did not alter MCAvmean ( P = 0.99) or MAP ( P = 0.39) compared with hyperthermia alone. Relative to hyperthermia, at 30-mmHg LBNP acute volume infusion attenuated reductions ( P < 0.001) in cardiac output (by 2.5 ± 0.9 l/min; P < 0.001), MAP (by 5 ± 6 mmHg; P = 0.004), and MCAvmean (by 12 ± 13%; P = 0.002). These data indicate that acute volume expansion does not reverse hyperthermia-induced reductions in cerebral perfusion pre-LBNP, but that it does attenuate reductions in cerebral perfusion during simulated hemorrhage in hyperthermic humans.
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Trinity, Joel D., Matthew D. Pahnke, Joshua F. Lee, and Edward F. Coyle. "Interaction of hyperthermia and heart rate on stroke volume during prolonged exercise." Journal of Applied Physiology 109, no. 3 (September 2010): 745–51. http://dx.doi.org/10.1152/japplphysiol.00377.2010.

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People who become hyperthermic during exercise display large increases in heart rate (HR) and reductions in stroke volume (SV). It is not clear if the reduction in SV is due primarily to hyperthermia or if it is a secondary effect of an elevation in HR reducing ventricular filling. In the present study, the upward drift of HR during prolonged exercise was prevented by a very small dose of the β1-adrenoreceptor blocker (atenolol; βB), thus allowing SV to be compared at a given HR during normothermia and hyperthermia. Eleven men cycled for 60 min at 57% of peak O2 uptake after receiving placebo control (PL) or a low dose (0.2 mg/kg) of βB. Hyperthermia was induced by reducing heat dissipation during exercise. Four experimental conditions were studied: normothermia-PL, normothermia-βB, hyperthermia-PL, and hyperthermia-βB. Hyperthermia increased skin and core temperature by 4.3°C and 0.8°C ( P < 0.01), respectively. βB prevented HR elevation with hyperthermia: HR values were similar at minute 60 during normothermia-PL and hyperthermia-βB (155 ± 11 and 154 ± 13 beats/min, respectively, P = 0.82). However, SV was increased by 7% during the final 20 min of exercise during hyperthermia-βB compared with normothermia-PL (treatment × time interaction, P = 0.03). In conclusion, when matched for HR, mild hyperthermia increased SV during exercise. Furthermore, the reduction in SV throughout prolonged exercise under normothermic and mildly hyperthermic conditions appears to be due to the increase in HR.
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Mammar, Mohamed Sidi, Xavier Vignon, Edmond Rock, Frederique Mathieu, and Gilles Gandemer. "Analysis of lipid composition of sarcoplasmic reticulum membranes from normal and malignant hyperthermic pig skeletal muscle." Biochemistry and Cell Biology 71, no. 7-8 (July 1, 1993): 324–30. http://dx.doi.org/10.1139/o93-049.

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In search of a general membrane defect hypothesis for malignant hyperthermia syndrome, we analysed the lipid profiles of heavy sarcoplasmic reticulum membranes isolated from normal and malignant hyperthermia longissimus dorsi pig muscle. Malignant hyperthermia susceptibility was assessed by halothane challenge of pigs. Sarcoplasmic reticulum membranes from malignant hyperthermia susceptible pigs differed significantly from control ones in the cholesterol content and phosphatidylethanolamine/phosphatidylcholine ratio; both were higher in former membranes. These latter lipid modifications were in agreement with the significant increase of their bulk lipid viscosity, as evidenced by an increase of diphenyl hexatriene fluorescence anisotropy. The increased level of phosphatidylethanolamine associated with the decreased content of phosphatidylcholine in malignant hyperthermic membranes was shown to be a potential consequence of depressed activities of both phospholipid N-methyltransferase I and II activities. Finally, the distribution of fatty acids in these particular phospholipids showed no change in phosphatidylcholine molecules, whereas the percentage of arachidonate and stearate in the phosphatidylethanolamine species were respectively higher and lower in malignant hyperthermic membranes. These differences in major phospholipids content and the enrichment of a metabolically important fatty acyl chains in malignant hyperthermia sarcoplasmic reticulum membranes strongly suggest that the lipid metabolism may contribute to the molecular mechanism of malignant hyperthermia syndrome.Key words: malignant hyperthermia, sacroplasmic reticulum, ryanodine, phospholipid N-methyltransferase, fluidity.
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Holt, David W. "Hyperthermia in Extracorporeal Technology." Journal of ExtraCorporeal Technology 21, no. 2 (June 1989): 65–72. http://dx.doi.org/10.1051/ject/1989212065.

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A review of the application of hyperthermia in the treatment of cancer is presented. The definition, historical background, biological rationale, indications and contraindications are discussed. The five basic methods of inducing hyperthermia as well as the five objective therapeutic modalities are reviewed. Hyperthermia for the treatment of cancer applied by extracorporeal circulation either alone or in conjunction with isolated regional perfusion is the specific target of the review. The published results demonstrating hyperthermic therapy as a “detrimental” therapy, an “indifferent” therapy or a “positive” therapy are explored (J. Extra-Corpor. Technol. 21(2): 65-72, 1989, 83 Ref).
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Tryba, Andrew K., and Jan-Marino Ramirez. "Hyperthermia Modulates Respiratory Pacemaker Bursting Properties." Journal of Neurophysiology 92, no. 5 (November 2004): 2844–52. http://dx.doi.org/10.1152/jn.00752.2003.

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Most mammals modulate respiratory frequency (RF) to dissipate heat (e.g., panting) and avoid heat stroke during hyperthermic conditions. Respiratory neural network activity recorded in an isolated brain stem-slice preparation of mice exhibits a similar RF modulation in response to hyperthermia; fictive eupneic frequency increases while inspiratory network activity amplitude and duration are significantly reduced. Here, we study the effects of hyperthermia on the activity of synaptically isolated respiratory pacemakers to examine the possibility that these changes may account for the hyperthermic RF modulation of the respiratory network. During heating, modulation of the bursting frequency of synaptically isolated pacemakers paralleled that of population bursting recorded from the intact network, whereas nonpacemaker neurons were unaffected, suggesting that pacemaker bursting may account for the temperature-enhanced RF observed at the network level. Some respiratory neurons that were tonically active at hypothermic conditions exhibited pacemaker properties at approximately the normal body temperature of eutherian mammals (36.81 ± 1.17°C; mean ± SD) and continued to burst at 40°C. At elevated temperatures (40°C), there was an enhancement of the depolarizing drive potential in synaptically isolated pacemakers, while the amplitude of integrated population activity declined. Isolated pacemaker bursting ceased at 41–42°C ( n = 5), which corresponds to temperatures at which hyperthermic-apnea typically occurs in vivo. We conclude that pacemaker properties may play an important role in the hyperthermic frequency modulation and apnea, while network effects may play important roles in generating other aspects of the hyperthermic response, such as the decreased amplitude of ventral respiratory group activity during hyperthermia.
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José, González-Alonso,, Ricardo Mora-Rodríguez, Paul R. Below, and Edward F. Coyle. "Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise." Journal of Applied Physiology 82, no. 4 (April 1, 1997): 1229–36. http://dx.doi.org/10.1152/jappl.1997.82.4.1229.

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González-Alonso, José, Ricardo Mora-Rodrı́guez, Paul R. Below, and Edward F. Coyle.Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise. J. Appl. Physiol. 82(4): 1229–1236, 1997.—We identified the cardiovascular stress encountered by superimposing dehydration on hyperthermia during exercise in the heat and the mechanisms contributing to the dehydration-mediated stroke volume (SV) reduction. Fifteen endurance-trained cyclists [maximal O2consumption (V˙o2 max) = 4.5 l/min] exercised in the heat for 100–120 min and either became dehydrated by 4% body weight or remained euhydrated by drinking fluids. Measurements were made after they continued exercise at 71%V˙o2 maxfor 30 min while 1) euhydrated with an esophageal temperature (Tes) of 38.1–38.3°C (control); 2) euhydrated and hyperthermic (39.3°C); 3) dehydrated and hyperthermic with skin temperature (Tsk) of 34°C; 4) dehydrated with Tesof 38.1°C and Tskof 21°C; and 5) condition 4 followed by restored blood volume. Compared with control, hyperthermia (1°C Tesincrease) and dehydration (4% body weight loss) each separately lowered SV 7–8% (11 ± 3 ml/beat; P < 0.05) and increased heart rate sufficiently to prevent significant declines in cardiac output. However, when dehydration was superimposed on hyperthermia, the reductions in SV were significantly ( P< 0.05) greater (26 ± 3 ml/beat), and cardiac output declined 13% (2.8 ± 0.3 l/min). Furthermore, mean arterial pressure declined 5 ± 2%, and systemic vascular resistance increased 10 ± 3% (both P < 0.05). When hyperthermia was prevented, all of the decline in SV with dehydration was due to reduced blood volume (∼200 ml). These results demonstrate that the superimposition of dehydration on hyperthermia during exercise in the heat causes an inability to maintain cardiac output and blood pressure that makes the dehydrated athlete less able to cope with hyperthermia.
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Baugher, Paige J. "Abstract 2878: Hyperthermia increases the efficacy of aminolevulinic acid-mediated photodynamic therapy in human osteosarcoma cells." Cancer Research 84, no. 6_Supplement (March 22, 2024): 2878. http://dx.doi.org/10.1158/1538-7445.am2024-2878.

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Abstract Osteosarcoma is a malignant osteoid tumor that arises from mesenchymal cells exhibiting osteoblastic differentiation. Common treatments for this neoplasm include limb-salvage surgery and/or amputation of the affected limb, either of which can substantially decrease quality of life. Therefore, other, less invasive treatments should be explored. Photodynamic therapy (PDT) represents a more targeted, less invasive treatment possibility for osteosarcoma. Previous data from my laboratory demonstrated that aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) can be used to induce significant cell death in human osteosarcoma MG-63 cells in vitro. However, delivering high doses of drugs to deep osteosarcoma tumors could prove difficult, so we aim to explore the use of combination therapies to increase the efficacy of ALA-PDT in human osteosarcoma cells. Previous studies have shown that hyperthermia (increased temperature) can induce cell death in cancer cells. Furthermore, data suggest that combining PDT with hyperthermia can induce cell death in cancer cells synergistically by activating differential death-inducing pathways. However, hyperthermia in combination with ALA-PDT has not been explored in human osteosarcoma. Therefore, we aim to investigate the possibility that hyperthermia in combination with ALA-PDT can increase cell death in human osteosarcoma cells compared to ALA-PDT alone. Data from our lab show that compared to normal body temperature (37°C), cell death in MG-63 human osteosarcoma cells was not significantly increased by mild hyperthermia alone (40°C and 43°C respectively), while moderate hyperthermic temperatures alone (46°C and 49°C) did significantly increase cell death. We also found that at moderately hyperthermic temperatures, ALA-PDT does not increase cell death any further compared to moderate hyperthermia alone. Furthermore, we found that at the mildly hyperthermic temperature of 40°C, cell death was not significantly increased any further by ALA-PDT compared to ALA-PDT alone. However, our data do show that at a temperature of 43°C, hyperthermia plus ALA-PDT increased cell death compared to ALA-PDT alone. Therefore, our data suggest that inducing mild hyperthermia could increase the efficacy of ALA-PDT in human osteosarcoma cells. Citation Format: Paige J. Baugher. Hyperthermia increases the efficacy of aminolevulinic acid-mediated photodynamic therapy in human osteosarcoma cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2878.
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Vertrees, Roger A., Joseph B. Zwischenberger, Lee C. Woodson, Eric A. Bedell, Donald J. Deyo, and Jill M. Chernin. "Veno-venous perfusion-induced systemic hyperthermia: case report with perfusion considerations." Perfusion 16, no. 3 (May 2001): 243–48. http://dx.doi.org/10.1177/026765910101600310.

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Cancer cells are more susceptible to destruction by heat than are their normal counterparts. However, optimization of this hyperthermic susceptibility for selective cancer cell kill has been difficult to define and technically difficult to achieve. A whole-body hyperthermic technique - veno-venous perfusion-induced systemic hyperthermia (VV-PISH) was designed in in vitro and in swine experiments to achieve selective hyperthermic cancer cell destruction. In this case report, VV-PISH is studied for its safety and therapeutic efficiency in a Food and Drug Administration (FDA) approved phase-I study, where hyperthermia is used to treat advanced (Stage III B or IV) lung cancer. VV-PISH, utilizing the ThermoChem™ HT system in an extracorporeal circuit, was used to induce hyperthermia to 42.5°C sustained for 120 min. Cooling returned the body temperature to 37°C. After completion of the treatment, the patient was transferred to the intensive care unit on a ventilator, norepinephrine and diuretics. The patient remained somnolent for 36 h, developed pulmonary congestion requiring an additional 48 h before extubation, was transferred to the intermediate unit on day 4 and discharged in good condition on day 8. He did experience hyperthermia-related shrinkage of his lung cancer; however, he succumbed 270 days after this treatment from further progression of this disease. Hyperthermia is not a benign therapy; management techniques have been developed that have ameliorated many of the problems associated with extremely high temperatures, but pathophysiology still exists. Using these techniques, VV-PISH can be safety implemented, albeit not without temporary sequelae and further hospitalization.
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Schwartz, A., D. Kaplan, V. Rosenzweig, M. Klein, B. F. Gruenbaum, S. E. Gruenbaum, M. Boyko, A. Zlotnik, and E. Brotfain. "The incidence of hyperthermia during cochlear implant surgery in children." Journal of Laryngology & Otology 131, no. 10 (August 15, 2017): 900–906. http://dx.doi.org/10.1017/s0022215117001682.

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AbstractBackground:Inadvertent hyperthermia during anaesthesia is a rare but life-threatening complication. We have encountered several cases of severe hyperthermia in paediatric patients undergoing anaesthesia for cochlear implantation.Methods:This study aimed to describe the clinical characteristics of children who developed hyperthermia while undergoing cochlear implantation, and to explore possible mechanisms and predisposing factors. The anaesthetic charts of all patients aged under 18 years who underwent cochlear implantation, or mastoid or ophthalmic surgery, between 1 January 2006 and 31 December 2009, at Soroka Medical Center in Beer Sheva, Israel, were reviewed. Patients undergoing mastoid and ophthalmic surgical procedures were used as controls.Results:A larger percentage of patients who underwent cochlear implant surgery (10 per cent) developed hyperthermia compared to controls (0.7 per cent, p < 0.05). In five of the seven cases, hyperthermia appeared in combination with tachycardia and hypercapnia, adhering to the clinical triad of malignant hyperthermia.Conclusion:Patients undergoing cochlear implantation are susceptible to developing intra-operative hyperthermia. This article describes the hyperthermic events that occur during paediatric cochlear implantation, and attempts to identify potential triggers of hyperthermia.
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Zhou, Xun, Jamal Bouitbir, Matthias E. Liechti, Stephan Krähenbühl, and Riccardo V. Mancuso. "Hyperthermia Increases Neurotoxicity Associated with Novel Methcathinones." Cells 9, no. 4 (April 14, 2020): 965. http://dx.doi.org/10.3390/cells9040965.

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Hyperthermia is one of the severe acute adverse effects that can be caused by the ingestion of recreational drugs, such as methcathinones. The effect of hyperthermia on neurotoxicity is currently not known. The primary aim of our study was therefore to investigate the effects of hyperthermia (40.5 °C) on the neurotoxicity of methcathinone (MC), 4-chloromethcathinone (4-CMC), and 4-methylmethcathinone (4-MMC) in SH-SY5Y cells. We found that 4-CMC and 4-MMC were cytotoxic (decrease in cellular ATP and plasma membrane damage) under both hyper- (40.5 °C) and normothermic conditions (37 °C), whereby cells were more sensitive to the toxicants at 40.5 °C. 4-CMC and 4-MMC impaired the function of the mitochondrial electron transport chain and increased mitochondrial formation of reactive oxygen species (ROS) in SH-SY5Y cells, which were accentuated under hyperthermic conditions. Hyperthermia was associated with a rapid expression of the 70 kilodalton heat shock protein (Hsp70), which partially prevented cell death after 6 h of exposure to the toxicants. After 24 h of exposure, autophagy was stimulated by the toxicants and by hyperthermia but could only partially prevent cell death. In conclusion, hyperthermic conditions increased the neurotoxic properties of methcathinones despite the stimulation of protective mechanisms. These findings may be important for the understanding of the mechanisms and clinical consequences of the neurotoxicity associated with these compounds.
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Dissertations / Theses on the topic "Hyperthermia"

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Nijhuis, Erwin. "Hyperthermia-induced apoptosis." Enschede : University of Twente [Host], 2008. http://doc.utwente.nl/59801.

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Habash, Riadh W. Y. "Non-Invasive Microwave Hyperthermia." Thesis, Indian Institute of Science, 1994. https://etd.iisc.ac.in/handle/2005/193.

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Presented in this thesis are the following theoretical investigations carried out on the non-invasive microwave hyperthermia of malignant tumours in the human body: Fundamental concepts of electromagnetic wave propagation through a biomass and its interaction with it, are discussed. Various types of applicators used for producing hyperthermia in a biomass, are also discussed. Propagation of a uniform plane electromagnetic wave through a human body is investigated for the general case of oblique incidence. Various models used for the human body have been discussed and the planar multilayer model has been chosen for this study. Reflection and transmission coefficients for both the parallel and perpendicular linear polarisations of the wave, have been determined. For normal incidence, power transfer ratio at the muscle has been defined and calculated at 433, 915 and 2450 MHz (ISM frequencies). Efects of skin thickness and also of fat thickness, on the power transfer ratio at muscle, have been studied. Effects of the thickness and dielectric constant of a bolus, and also of the dielectric constant of an initial layer, on the power transfer ratio, have been studied and their optimum values obtained at the ISM frequencies. For microwave hyperthermia, 915 MHz is recommended as the frequency of operation. Steady-state solution of the bioheat transfer equation has been obtained, assuming the biomass to be a semi-infinite homogeneous medium. Effects of various physical parameters on the temperature profile in the biomass, have been studied. Also studied is the effect of the surface temperature on the magnitude, location and the width of the temperature peak attained in the biomass. A method to determine the microwave power and the surface temperature required to produce a prescribed temperature profile in the biomass, has been developed. The transient-state solution of the bioheat transfer equation has been obtained to study the building up of the temperature profile. Procedures for the design of an open-ended rectangular metal waveguide applicator and for estimating the total microwave power requirement to produce hyperthermia in the human body, have been developed. Performance of the applicators employing linear as well as planar arrays of open-ended rectangular metal waveguide antennas, has also been studied. In order to reduce the overall physical size of the applicators, filling up of the feed waveguide with a high dielectric constant but low loss material is suggested. A simple method of obtaining the elements of the array by partitioning a large aperture by using metal walls has been adopted. Calculation of the total microwave power required by various applicators for producing hyperthermia at various depths in a biomas, have been made and a comparison of the performance of various applicators, has been presented.
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Habash, Riadh W. Y. "Non-Invasive Microwave Hyperthermia." Thesis, Indian Institute of Science, 1994. http://hdl.handle.net/2005/193.

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Presented in this thesis are the following theoretical investigations carried out on the non-invasive microwave hyperthermia of malignant tumours in the human body: Fundamental concepts of electromagnetic wave propagation through a biomass and its interaction with it, are discussed. Various types of applicators used for producing hyperthermia in a biomass, are also discussed. Propagation of a uniform plane electromagnetic wave through a human body is investigated for the general case of oblique incidence. Various models used for the human body have been discussed and the planar multilayer model has been chosen for this study. Reflection and transmission coefficients for both the parallel and perpendicular linear polarisations of the wave, have been determined. For normal incidence, power transfer ratio at the muscle has been defined and calculated at 433, 915 and 2450 MHz (ISM frequencies). Efects of skin thickness and also of fat thickness, on the power transfer ratio at muscle, have been studied. Effects of the thickness and dielectric constant of a bolus, and also of the dielectric constant of an initial layer, on the power transfer ratio, have been studied and their optimum values obtained at the ISM frequencies. For microwave hyperthermia, 915 MHz is recommended as the frequency of operation. Steady-state solution of the bioheat transfer equation has been obtained, assuming the biomass to be a semi-infinite homogeneous medium. Effects of various physical parameters on the temperature profile in the biomass, have been studied. Also studied is the effect of the surface temperature on the magnitude, location and the width of the temperature peak attained in the biomass. A method to determine the microwave power and the surface temperature required to produce a prescribed temperature profile in the biomass, has been developed. The transient-state solution of the bioheat transfer equation has been obtained to study the building up of the temperature profile. Procedures for the design of an open-ended rectangular metal waveguide applicator and for estimating the total microwave power requirement to produce hyperthermia in the human body, have been developed. Performance of the applicators employing linear as well as planar arrays of open-ended rectangular metal waveguide antennas, has also been studied. In order to reduce the overall physical size of the applicators, filling up of the feed waveguide with a high dielectric constant but low loss material is suggested. A simple method of obtaining the elements of the array by partitioning a large aperture by using metal walls has been adopted. Calculation of the total microwave power required by various applicators for producing hyperthermia at various depths in a biomas, have been made and a comparison of the performance of various applicators, has been presented.
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Duong, Lawrence. "Computational electromagnetics in microwave hyperthermia." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83861.

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Microwave hyperthermia is a cancer treatment used in combination with radiotherapy and/or chemotherapy. Hyperthermia sensitizes cancer cells to the primary treatment by sublethal heat. An antenna array non-invasively launches electromagnetic waves, targeting cancer cells, and produces preferential heating. This thesis discusses the two-arm Archimedean spiral antenna as a possible antenna to deliver such energy.
Simulations are performed on a homogeneous cylindrical numerical phantom using the finite-difference time-domain (FDTD) method. FDTD is well-suited for the analysis of the interaction between electromagnetic waves and complex media.
This thesis explores two types of input signals to the antenna array: a continuous wave and a pulse. By strategically changing the phase of the continuous wave or the delay of the pulse of individual antenna elements, spots of maximal energy deposition within the phantom can be controlled. In the case of pulse-excited antenna array, temperature distribution is also computed.
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Thomas, L. "Nanoparticle synthesis for magnetic hyperthermia." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/646236/.

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This work reports on an investigation into the synthesis, control, and stabilisation of iron oxide nanoparticles for biomedical applications using magnetic hyperthermia. A new understanding of the factors effecting nanoparticle growth in a coprecipitation methodology has been determined. This thesis challenges the highly cited Ostwald Ripening as the primary mechanism for nanoparticulate growth, and instead argues that in certain conditions, such as increasing reaction temperature, a coalescence mechanism could be favoured by the system. Whereas in a system with a slower rate of addition of the reducing agent, Ostwald ripening is the favoured mechanism. The iron oxide nanoparticles made in the study were stabilised and functionalised for the purpose of stability in physiological environments using either carboxylic acid or phosphonate functionalised ligands. It was shown that phosphonate ligands form a stronger attachment to the nanoparticle surface and promote increased stability in aqueous solutions, however, this affected the magnetic properties of the particles and made them less efficient heaters when exposed to an alternating magnetic fields. Tiopronin coated iron oxide nanoparticles were a far superior heater, being over four times more effective than the best commercially available product. Due to its strong response, experiments into the antimicrobial properties of tiopronin coated iron oxide nanoparticles were undertaken, specifically on Staphylococcus aureus, to our knowledge this is the first time magnetic hyperthermia has been used for such an application. At concentrations of 50 mg/ml the sample was capable of complete bacterial kills following exposure to the in-house magnetic hyperthermia MACH system. Aging and oxidation over a period of a month did decrease the performance of the particles to kill bacteria using MACH heating, however they were still shown to be effective in killing Staphylococcus aureus.
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Neufeld, Esra. "High resolution hyperthermia treatment planning." Konstanz Hartung-Gorre, 2008. http://d-nb.info/992327873/04.

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Flores, Glen P. "Ferroelectric hyperthermia for cancer therapy." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0001113.

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Taylor, Arthur. "Engineering Carbon Encapsulated Nanomagnets towards Their Use for Magnetic Fluid Hyperthermia." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-63695.

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Magnetic fluid hyperthermia is a potential therapy for achieving interstitial hyperthermia and is currently under clinical trials. This approach is based on the instillation of magnetic nanoparticles at the tumour site, which dissipate heat when exposed to an alternating magnetic field. This procedure leads to a local increase of temperature and induction of tumour death or regression. Nanoparticles of metallic iron are potential heating agents for this therapy, but rely on the presence of a protecting coat that avoids reactions with their environment. In this work, iron nanospheres and iron nanowires with a graphite coat are explored for this purpose. From these two nanostructures, the nanospheres are shown to have a greater potential in terms of heat dissipation. The graphite shell is further investigated as an interface for conjugation with other molecules of relevance such as drugs and fluorescent probes. The effect of acidic treatments on the magnetic and surface properties of the nanospheres is systematically studied and a suitable method to generate carboxylic functionalities on the nanoparticle surface alongside with a good preservation of the magnetic properties is developed. These carboxylic groups are shown to work as a bridge for conjugation with a model molecule, methylamine, as well as with a fluorescent dye, allowing the detection of the nanoparticles in cells by means of optical methods. The carboxylic functionalities are further explored for the conjugation with the anti-cancer drug cisplatin, where the amount of drug loaded per particle is found to be dependent on the density of free carboxylic groups. The release of the drug in physiological salt solutions is time and temperature dependent, making them particularly interesting for multi-modal anti-cancer therapies, where concomitant hyperthermia and chemotherapy could be achieved. Their potential for such therapies is shown in vitro by inducing hyperthermia in cell suspensions containing these nanoparticles. These results are finally translated to a three dimensional cell culture model where the in vitro growth of tumour spheroids is inhibited. The developed nanostructures have a great potential for therapeutic approaches based on the synergistic effects of hyperthermia and chemotherapy.
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Niculaes, Dina. "Iron oxide nanocubes for magnetic hyperthermia." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/441740.

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Durant la meva tesi s’han desenvolupat tres projectes principals, centrats en l'estudi de nanosistemes basats en l'ús de nanocubs d'òxid de ferro (IONCs) per a la hipertèrmia magnètica (HM). S’ha demostrat l'ús innovador de la configuració de HM per a l'oxidació suau de nanocubs tipus core-shell Fe1-xO/Fe3-δO4 a una única fase de Fe3O4. Atès que els valors de la taxa d'absorció específica (SAR) dels nanocubs tipus core-shell wüstita/magnetita han estat menors en comparació amb els IONCs de magnetita amb una longitud d’aresta de cub similar, el nucli de FeO s’ha oxidat mitjançant estimulació MH. Després de diversos tractaments amb HM, els valors de SAR s’han duplicat, mentre que l'estabilitat col·loïdal, la distribució de mida i la forma no s’han vist afectades. Els IONCs estimulats magnèticament han mostrat un valor de magnetització de saturació més elevat, reflectint canvis estructurals i de composició, confirmats a través d'estudis de microscòpia electrònica i de dispositius superconductors d'interferència quàntica. El tractament suau amb HM també ha fet possible l'ancoratge de molècules biològicament rellevants a la superfície dels nanocubs, preservant la seva activitat i millorant alhora el rendiment tèrmic dels IONCs. Els valors de SAR de IONCs tipus core-shell també s'han millorat acoblant els nanocubs en estructures de tipus cadena. Inicialment, es va desenvolupar l'agregació controlada dels IONCs durant la seva transferència en aigua, permetent la formació d'agregats (clústers) amb formats hidrodinàmics mitjans entre 30 i 100 nm. Així mateix, s’ha avaluat la resposta d’hipertèrmia de nanocubs individuals envers de nanoclústers col·loïdals tous de diferents mides. Les estructures denominades "dímers" i "trímers"—2D formades amb dos i tres IONCs—han mostrat valors SAR més alts. S’ha aconseguit la càrrega de fàrmac en dos nanosistemes dissenyats per alliberament de fàrmac quimioterapèutic desencadenat mitjançant calor. Tots dos sistemes s’han basat en IONCs de magnetita revestits amb polímers termo-responsius carregats amb doxorubicina. L'objectiu era obtenir nanotransportadors estables a la temperatura corporal que alliberessin la càrrega exclusivament sota l'aplicació d'un camp magnètic altern (AMF). D'aquesta manera, un cop obtinguts els IONCs individuals revestits amb polímer termo-responsiu amb alts
Tres proyectos principales se desarrollaron durante mi tesis centrada en el estudio de nanosistemas basados en el uso de nanocubos de óxido de hierro (IONCs) para la hipertermia magnética (HM). Se demostró el uso novedoso de la configuración de HM para la oxidación suave de nanocubos tipo core-shell Fe1-xO/Fe3-δO4 a una única fase de Fe3O4. Dado que los valores de la tasa de absorción específica (SAR) de los nanocubos tipo core-shell wüstita/magnetita fueron menores en comparación con los IONCs de magnetita con una longitud de borde de cubo similar, el núcleo de FeO se oxidó mediante estimulación MH. Después de varios tratamientos con HM, los valores de SAR se duplicaron, mientras que la estabilidad coloidal, la distribución del tamaño y la forma no se vieron afectadas. Los IONCs estimulados magnéticamente mostraron un valor de magnetización de saturación más elevado, reflejando cambios estructurales y de composición, confirmados a través de estudios de microscopía electrónica y de dispositivos superconductores de interferencia cuántica. El tratamiento suave con HM también hizo posible el anclaje moléculas biológicamente relevantes a la superficie de los nanocubos preservando su actividad y mejorando al mismo tiempo el rendimiento térmico de los IONCs. Los valores de SAR de IONCs tipo core-shell también se han mejorado ensamblando los nanocubos en estructuras de tipo cadena. Inicialmente, se desarrolló la agregación controlada de los IONCs durante su transferencia en agua, permitiendo la formación de agregados (clusters) con tamaños hidrodinámicos medios entre 30 y 100 nm. Asimismo, se evaluó la respuesta de hipertermia de nanocubos individuales frente a nanoclusters coloidales blandos de diferentes tamaños. Las estructuras denominadas "dímeros" y "trímeros"—2D formadas con dos y tres IONCs—mostraron valores SAR más altos. Se logró la carga de fármaco en dos nanosistemas diseñados para liberación de fármaco quimioterapéutico desencadenada mediante calor. Ambos sistemas se basaron en IONCs de magnetita revestidas con polímeros termo-responsivos cargados con doxorrubicina. El objetivo era obtener nanotransportadores estables a la temperatura corporal que liberaran la carga exclusivamente bajo la aplicación de un campo magnético alterno (AMF). De este modo, una vez obtenidos los IONCs individuales revestidos con
Three main projects were conducted during my thesis that was focused on the study of nanosystems based on iron oxide nanocubes (IONCs) for magnetic hyperthermia (MH). The novel use of MH set-up for the mild oxidization of Fe1-xO/Fe3-δO4 core-shell nanocubes to single Fe3O4 phase was demonstrated. As specific absorption rate (SAR) values of wüstite/magnetite core-shell nanocubes were lower compared to magnetite IONCs of similar cube edge length, the FeO core was oxidized by MH stimulation. After several MH treatments, the SAR values increased twice, while colloidal stability, size distribution and shape remained unaffected. The magnetically stimulated IONCs showed higher saturation magnetization, reflecting structural and compositional changes, as confirmed by electron microscopy and superconductive quantum interference device studies. The mild MH treatment also opened up the possibility of attaching biologically relevant molecules to the surface of nanocubes and preserving their activity while improving the IONCs heat performance. The SAR values of core-shell IONCs were also enhanced by clustering the nanocubes in chain like structures. Initially, the controlled clustering of the IONCs during their water transfer was developed, enabling the formation of clusters with mean hydrodynamic sizes between 30 and 100 nm. The hyperthermia response of individual nanocubes vs. soft colloidal nanoclusters of different sizes was evaluated. The so called “dimers” and “trimers”—2D structures formed with two and three IONCs—showed higher SAR values. Drug loading on two nanosystems designed for heat-triggered chemotherapeutic drug release was achieved. Both systems were based on magnetite IONCs coated with thermo-responsive polymers loaded with doxorubicin. The goal was to have stable nanocarriers at body temperature that would release the cargo exclusively upon the application of an alternating magnetic field (AMF). Once individually thermo-responsive polymer coated IONCs with high SAR values were obtained, the heat-triggered doxorubicin release under AMF—at biologically relevant field conditions—was qualitatively, but not quantitatively proven.
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Ramasamy, Manoshika. "Material analysis of wearabale hyperthermia applicator." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/20371.

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Master of Science
Department of Apparel, Textiles, and Interior Design
Minyoung Suh
The purpose of this study was to explore printed antennas as an alternative technique for applying hyperthermia treatment. The antenna consisted of a printed ground plane and a thin copper plate. The ground plane was made of silver conductive ink printed on a flexible substrate. The challenge of the printed ground plane was limited conductivity. Multi-layer printing was one of the ways to increase the conductivity of the printed trace. This study examined whether the multiple-layered printings on the ground plane influence the performance of the antenna. The ground plane printed on a flexible substrate was evaluated for its conductivity and capacity to handle the heat energy for the extended time duration at the elevated temperature. This research was conducted in two experimental stages. The first stage of the experiment was designed to test conductivity of the ground plane. Ground planes were printed on a 32.5 mm × 17.0 mm substrate. The thickness and resistance of up to five layers of conductive printing were tested to verify how repeated printing improved the resistance and resistivity. Results showed that the multi-layering technique reduced the resistance of the printed trace, but statistically, the ground plane had no significant improvement in resistance beyond the triple layer printing. With an increase of the thickness, resistivity rather increased after the triple layer printing. The second stage of the experiment was used to assess the performance of the entire antenna. Antennas were fabricated using ground planes with triple and quintuple layers based on resistance and resistivity measurements. The antennas showed an acceptable level of performance in terms of antenna return loss and temperature elevation. The statistical analysis of return loss, power handling capability over the time, and temperature elevation was not significant among the antennas with triple and quintuple layered ground planes. Antennas were able to achieve 42 ˚C within 10 minutes at a 2cm deep location with the return loss of -13.76 dB. Most importantly, experimental results showed that antennas were able to handle 15 watt power without degrading the antenna performance. The antenna showed a successful performance in power handling and reaching the tumor temperature.
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Books on the topic "Hyperthermia"

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1921-, Bergmann H., Mauritz W, Steinbereithner Karl 1920-, and Ludwig Boltzmann-Institut für Experimentelle Anaesthesiologie und Intensivmedizinische Forschung. Symposium., eds. Maligne Hyperthermie =: Malignant hyperthermia. Wien: Verlag Wilhelm Maudrich, 1989.

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M, Ross W., and Ross W. M, eds. Hyperthermia. Glasgow: Blackie, 1986.

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Ohnishi, S. Tsuyoshi, and Tomoko Ohnishi. Malignant Hyperthermia. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780138748435.

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Britt, Beverley A., ed. Malignant Hyperthermia. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2079-1.

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Morio, Michio, Hirosato Kikuchi, and Osafumi Yuge, eds. Malignant Hyperthermia. Tokyo: Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-68346-9.

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Hinkelbein, Wolfgang, Gregor Bruggmoser, Rupert Engelhardt, and Michael Wannenmacher, eds. Preclinical Hyperthermia. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-83263-5.

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Handl-Zeller, Leonore, ed. Interstitial Hyperthermia. Vienna: Springer Vienna, 1992. http://dx.doi.org/10.1007/978-3-7091-9155-2.

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A, Britt Beverley, ed. Malignant hyperthermia. Boston: Nijhoff, 1987.

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1948-, Hinkelbein W., ed. Preclinical hyperthermia. Berlin: Springer-Verlag, 1988.

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Handl-Zeller, Leonore. Interstitial Hyperthermia. Vienna: Springer Vienna, 1992.

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Book chapters on the topic "Hyperthermia"

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Dewhirst, Mark W. "Hyperthermia." In Cancer Management in Man, 159–64. Dordrecht: Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-1095-9_15.

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Nivoche, Y., and J. Marty. "Hyperthermia." In Care of the Critically Ill Patient, 1115–24. London: Springer London, 1992. http://dx.doi.org/10.1007/978-1-4471-3400-8_65.

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Rübe, Claudia E., Bernadine R. Donahue, Jay S. Cooper, Caspian Oliai, Yan Yu, Laura Doyle, Rene Rubin, et al. "Hyperthermia." In Encyclopedia of Radiation Oncology, 336–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_6.

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Manzoor, Ashley A., and Mark W. Dewhirst. "Hyperthermia." In Encyclopedia of Cancer, 1–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_2915-2.

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Gommeren, Kris. "Hyperthermia." In Complications in Small Animal Surgery, 66–71. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119421344.ch11.

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El-Radhi, A. Sahib. "Hyperthermia." In Clinical Manual of Fever in Children, 29–51. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92336-9_2.

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Sainburg, Robert L., Andrew L. Clark, George E. Billman, Zachary J. Schlader, Toby Mündel, Kevin Milne, Earl G. Noble, et al. "Hyperthermia." In Encyclopedia of Exercise Medicine in Health and Disease, 424. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2510.

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Manzoor, Ashley A., and Mark W. Dewhirst. "Hyperthermia." In Encyclopedia of Cancer, 2179–86. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_2915.

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Manzoor, Ashley A., and Mark W. Dewhirst. "Hyperthermia." In Encyclopedia of Cancer, 1785–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_2915.

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Chang, David S., Foster D. Lasley, Indra J. Das, Marc S. Mendonca, and Joseph R. Dynlacht. "Hyperthermia." In Basic Radiotherapy Physics and Biology, 297–301. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-06841-1_30.

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Conference papers on the topic "Hyperthermia"

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Ma, Na, Ping Liu, Chao Chen, Aili Zhang, and Lisa X. Xu. "Thermal Environmental Effect on Breast Tumor Growth." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206229.

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Tissue hypoxia is a common and important feature of rapidly growing malignant tumors and their metastases. Tumor cells mainly depend on energy production thru anaerobic glycolysis rather than aerobic oxidative phosphorylation in mitochondria [1]. Intervening the tumor metabolic process via thermal energy infusion is worthy attempting. And hyperthermia, mildly elevated local temperature above the body temperature, is one of such kind. Previously, after being heated for a short period of time, tumor glucose and lactate level increased and ATP level decreased, which suggested energy metabolism was modified following hyperthermia through increased ATP hydrolysis, intensified glycolysis and impaired oxidative phosphorylation [2]. Many researchers designed experiments to determine thermal dose in hyperthermia [3], but few focused on the relationship between tumor and energy, especially for a long-term local hyperthermia treatment. One clinical trial indicated the effective long-term hyperthermo-therapy for maintaining performance status, symptomatic improvement, and prolongation of survival time in patients with peritoneal dissemination [4].
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Cozzone, P., G. Kozak Ribbens, S. Confort Gouny, D. Figarella Branger, M. Aubert, and D. Bendahan. "SP0083 Effort-induced hyperthermia: similarities with malignant hyperthermia." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.30.

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Deng, Zhong-Shan, and Jing Liu. "Theoretical Evaluation on the Thermal Effects of Extracellular Hyperthermia and Intracellular Hyperthermia." In 2007 First International Conference on Integration and Commercialization of Micro and Nanosystems. ASMEDC, 2007. http://dx.doi.org/10.1115/mnc2007-21263.

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Although not currently a routine cancer treatment therapy, hyperthermia is developing rather rapidly as an alternative way as part of conventional treatment for some cancers. This treatment takes advantage of the high sensitivity of tumor cell to heat. Up to now, a variety of heating methods have been established to induce temperature rises either locally in target tissue region, or over the whole body. Among them, magnetic nano-particles offer some attractive possibilities in tumor hyperthermia, which have controllable sizes ranging from a few nanometers up to tens of nanometers. The magnetic nano-particles can be made to resonantly respond to a time-varying electromagnetic (EM) field, with advantageous results related to the transfer of energy from the exciting field to the nano-particles. This heat then efficiently conducts into the surrounding diseased cells and tissues. A major concern involved in magnetic nano-hyperthermia is about the controversy that whether intracellular hyperthermia is superior to extracellular hyperthermia [1]. The potential of time-varying EM heating effects in a scale length smaller than the biological cell diameter was first addressed by Gordon et al. and termed as “intracellular hyperthermia” [2]. Since experimental validation of the thermal effects of intracellular hyperthermia is still not feasible with the current experimental technique, this problem has been studied theoretically. However, different researchers have suggested different results, and the controversy still goes on [1–3]. In order to understand the exact micro-mechanisms of EM heating involved in intracellular hyperthermia and extracellular hyperthermia, an energy analysis is presented in this study to simulate the corresponding heat transfer problems thus involved. Different from intracellular hyperthermia, the main characteristic of the extracellular hyperthermia is to heat up the target tissue by EM energy absorption only in the extracellular medium. A series of numerical calculations for both intracellular hyperthermia and extracellular hyperthermia are performed. The results will answer the question from the heat transfer mechanism whether intracellular hyperthermia is superior to extracellular hyperthermia in the thermal sense.
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Qin, Zhenpeng, Neha Shah, Taner Akkin, Warren C. W. Chan, and John C. Bischof. "Thermal Analysis Measurement of Gold Nanoparticle Interactions With Cell and Biomaterial." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80554.

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The rapidly evolving field of nanomedicine focuses on the design and application of multi-functional nanoparticles for diagnosis and treatment of diseases especially cancer1. Many of these nanomaterials are designed to serve as drug delivery or image contrast agents, or even to generate heat for hyperthermia (i.e. treatment), of cancer. Heating examples include gold nanoparticles (GNPs) for photothermal therapy3, and superparamagnetic nanoparticles for magnetic fluid hyperthermia4.
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Mocna, Marta, Carlos Granja, Claude Leroy, and Ivan Stekl. "Hyperthermia in Oncology." In Nuclear Physics Medthods and Accelerators in Biology and Medicine. AIP, 2007. http://dx.doi.org/10.1063/1.2825805.

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Deng, Zhong-Shan, and Jing Liu. "Conformal Tumor Treatment by the Combined Cryosurgical and Hyperthermic System: Optimal Configuration of the Multiple Probes." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43920.

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Recently, a minimally invasive probe system capable of performing both cryosurgery and hyperthermia treatment for deep tumor was developed. With the increasing applications of such combined system, it becomes apparent that without optimal configuration of the multiple probes during multiple freeze/heat cycles, it is difficult produce a conformal lesion in the tumor tissue, which may lead to either insufficient or excessive freezing/heating and consequently, to tumor recurrence or to destruction of healthy tissue. In this study, a comprehensive three-dimensional numerical investigation is performed to design optimal configurations of the multiple probes used in the combined cryosurgical and hyperthermic treatment. The results presented in this study will be useful for treatment planning of the combined cryosurgical and hyperthermic treatment.
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Zhang, Aili, Xipeng Mi, and Lisa X. Xu. "Study of Thermally Targeted Nano-Particle Drug Delivery for Tumor Therapy." In ASME 2008 First International Conference on Micro/Nanoscale Heat Transfer. ASMEDC, 2008. http://dx.doi.org/10.1115/mnht2008-52383.

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The efficacy of cancer chemotherapeutics could be greatly enhanced by thermally targeted nanoparticle liposome drug delivery system. The tumor microvasculature response to hyperthermia and its permeability to the nano-liposomes were studied using the 4T1 mouse model and confocal fluorescence microscopy. Based on the experimental results, a new theoretical model was developed to describe the distributions of both the liposomal and free drug released as liposomes broke in tumor for treatment evaluation. In this model, the tumor was divided into two regions: peripheral and central. The drug effect on the tumor cell apoptosis and necrosis was considered. Upon the experimental validation, the model was used to simulate drug distribution in the tumor under either the hyperthermic or the alternate freezing and heating condition. Results showed that hyperthermia alone only enhanced drug accumulation in the tumor periphery and therefore more serious tumor damage induced in the region. But the tumor cells in the central region were hardly damaged due to the lack of drug diffusion. The alternate freezing and heating was proposed to aid the nanoliposomal drug delivery, and better results were found.
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Weatherburn, H. "Hyperthermia and AIDS treatment." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1988. http://dx.doi.org/10.1109/iembs.1988.95370.

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Johnson, R. H., A. W. Preece, and J. L. Murfin. "Flexible electromagnetic hyperthermia applicator." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1988. http://dx.doi.org/10.1109/iembs.1988.94978.

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Wessalowski, Rudiger, Richard Canters, and Gerard C. van Rhoon. "EMF hyperthermia in children." In 2012 42nd European Microwave Conference (EuMC 2012). IEEE, 2012. http://dx.doi.org/10.23919/eumc.2012.6459101.

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Reports on the topic "Hyperthermia"

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Dunscombe, P. B., Thomas C. Cetas, William G. Connor, Evan B. Douple, Fred W. Hetzel, W. Kaith Lee, David Loshek, et al. Hyperthermia Treatment Planning. AAPM, 1989. http://dx.doi.org/10.37206/26.

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lbbott, Geoffrey S., Ivan Brezovich, Peter Fessenden, Yakov Pipman, Taljit Sandhu, V. Sathiaseelan, Paul Stauffer, Adrianne Galdi, and Tillman Saylor. Performance Evaluation of Hyperthermia Equipment. AAPM, 1989. http://dx.doi.org/10.37206/25.

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Panyam, Jayanth. Targeted Magnetic Hyperthermia for Lung Cancer. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada568987.

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Panyam, Jayanth. Targeted Magnetic Hyperthermia for Lung Cancer. Fort Belvoir, VA: Defense Technical Information Center, September 2013. http://dx.doi.org/10.21236/ada592043.

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Panyam, Jayanth. Targeted Magnetic Hyperthermia for Lung Cancer. Fort Belvoir, VA: Defense Technical Information Center, November 2014. http://dx.doi.org/10.21236/ada620276.

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Guha, Chandan. Immunomodulation of Hyperthermia for Recurrent Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, March 2005. http://dx.doi.org/10.21236/ada437721.

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Guha, Chandan. Immunomodulation of Hyperthermia for Recurrent Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, March 2006. http://dx.doi.org/10.21236/ada456006.

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Williams, Kenneth A. Malignant Hyperthermia Preparation in the United States Air Force. Fort Belvoir, VA: Defense Technical Information Center, September 1999. http://dx.doi.org/10.21236/ad1012257.

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Lee, Lu-Yuan. Pulmonary Stress Induced by Hyperthermia: Role of Airway Sensory Nerves. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada612760.

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Lee, Lu-Yuan. Pulmonary Stress Induced by Hyperthermia: Role of Airway Sensory Nerves. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada612762.

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