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1

Sica, Domenic A. "Hypertension Treatment." Hypertension 50, no. 2 (August 2007): 287–88. http://dx.doi.org/10.1161/hypertensionaha.107.092114.

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2

Dustan, Harriet P. "Hypertension Treatment." Archives of Internal Medicine 156, no. 17 (September 23, 1996): 1913. http://dx.doi.org/10.1001/archinte.1996.00440160013002.

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3

Shimamoto, Kazuaki. "Hypertension treatment for elderly hypertension." Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 40, no. 3 (2003): 213–15. http://dx.doi.org/10.3143/geriatrics.40.213.

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4

ARAKAWA, KIKUO. "Hypertension : progress in diagnosis and treatment. Treatment. General treatment of hypertension." Nihon Naika Gakkai Zasshi 79, no. 1 (1990): 33–37. http://dx.doi.org/10.2169/naika.79.33.

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5

Zanchetti, Alberto. "Challenges of hypertension and hypertension treatment." Journal of Hypertension 32, no. 10 (October 2014): 1917–18. http://dx.doi.org/10.1097/hjh.0000000000000359.

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6

Mushtaq, Ayesha. "The Nutrition Therapy, Treatment, Pathophysiology, Etiology, Epidemiology of Hypertension." Journal of Food and Nutrition 1, no. 2 (December 7, 2022): 01–04. http://dx.doi.org/10.58489/2836-2276/008.

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Hypertension is both a cardiovascular condition and risk factor for other forms of cardiovascular disease. An increase in BP increases the forces applied to the endothelium and can cause initiation of an atherosclerotic lesion. Changes in pressure may also cause established plaques to rupture, which not only can initiate an event such as an infarct but also cause a proliferation of existing plaques. From 40 to 70 years of age, an increase of systolic BP by 20 mmHg increases risk of CVD in systolic blood pressure of hypertensive will prevent one death for every 11 patients treated. Basically, hypertension is a condition of chronically elevated blood pressure. Nutrition treatment of hypertension include lifestyle modification in which nutrition therapy, physical activity, ideal BMI, weight loss goals are added to prevent the more risk. Furthermore, the DASH is used to approach the nutrition therapy for hypertension. Minerals are added to diet to treat the hypertension i.e., potassium, calcium magnesium have all been positively correlated with reduction of BP and treatment of hypertension. It is important to remember that the nutritional effects demonstrated by the DASH study and in particular the relationship between K, Ca, Mg and blood pressure reduction were a result of a dietary pattern rich in these nutrients rather than mineral intake from supplements.
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7

&NA;. "Hypertension treatment recommendations." Inpharma Weekly &NA;, no. 1198 (July 1999): 2. http://dx.doi.org/10.2165/00128413-199911980-00002.

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8

Takahashi, Atsuhiko, and Toshio Kushiro. "Hypertension treatment guidelines." Health Evaluation and Promotion 39, no. 2 (2012): 285–94. http://dx.doi.org/10.7143/jhep.39.285.

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9

Milošević, Maja, and Petar Otašević. "Treatment-resistant hypertension." Arhiv za farmaciju 72, no. 1 (2022): 1–19. http://dx.doi.org/10.5937/arhfarm72-34248.

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Treatment-resistant hypertension is one of the most significant causes of poor blood pressure regulation. Patients with resistant hypertension are at a higher risk of developing comorbidities compared to the general hypertensive population. As a result, these patients have an increased incidence of disability and premature death, as well as increased treatment costs. Due to the above-mentioned, in the last decade, there has been an increase in researchers' interest in elucidating the pathogenesis, diagnosis, and treatment of resistant hypertension. However, recent data indicate that 20% of female and 24% of male patients with arterial hypertension still have uncontrolled blood pressure, despite maximum doses of three antihypertensive drugs (including a diuretic) and appropriate lifestyle measures. New treatment modalities (i.e. devicebased interventions - catheter-based renal denervation and baroreceptor stimulation) offer hope for achieving adequate blood pressure regulation in these patients. In this paper, we have summarized previous knowledge about the mechanisms underlying the pathogenesis of resistant hypertension, as well as optimal diagnostic methods to differentiate true from pseudo-resistant hypertension. We have also given an overview of the current therapeutic approach, including optimal medical therapy and new treatment modalities (i.e. device-based interventions) and their role in the treatment of resistant hypertension.
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10

Dustan, Harriet P. "Treatment of Hypertension." Southern Medical Journal 90, Supplement (December 1997): 1. http://dx.doi.org/10.1097/00007611-199712001-00001.

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11

Volpe, Massimo. "Treatment of Hypertension." High Blood Pressure & Cardiovascular Prevention 10, no. 1 (2003): 7–9. http://dx.doi.org/10.2165/00151642-200310010-00003.

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12

Murdoch, J. C. "Treatment of Hypertension." Journal of Cardiovascular Pharmacology 16 (1990): S108—S109. http://dx.doi.org/10.1097/00005344-199000167-00034.

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13

Murdoch, J. C. "Treatment of Hypertension." Journal of Cardiovascular Pharmacology 16 (1990): S108—S109. http://dx.doi.org/10.1097/00005344-199006167-00034.

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14

Poulter, Neil R. "Treatment of Hypertension." Journal of Cardiovascular Pharmacology 18 (1991): S35—S38. http://dx.doi.org/10.1097/00005344-199100182-00008.

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15

Ménard, Joël. "Improving Hypertension Treatment." American Journal of Hypertension 5, no. 12_Pt_2 (December 1992): 252S—258S. http://dx.doi.org/10.1093/ajh/5.12.252s.

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16

Chapman, John, and Marie Bent. "Treatment of hypertension." Practice Nursing 10, no. 17 (October 19, 1999): 29–30. http://dx.doi.org/10.12968/pnur.1999.10.17.29.

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17

Moser, Marvin, Vasilios Papademetriou, Thomas G. Pickering, and Domenic A. Sica. "Hypertension Treatment Guidelines." Journal of Clinical Hypertension 6, no. 8 (August 2004): 452–57. http://dx.doi.org/10.1111/j.1524-6175.2004.03745.x.

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18

Withers, Sarah B., Sophie N. Saxton, and Anthony M. Heagerty. "Personalizing Hypertension Treatment?" Hypertension 71, no. 6 (June 2018): 1028–29. http://dx.doi.org/10.1161/hypertensionaha.118.11107.

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19

Bolli, Peter. "Treatment Resistant Hypertension." American Journal of Therapeutics 15, no. 4 (July 2008): 351–55. http://dx.doi.org/10.1097/mjt.0b013e318164c67b.

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20

Sanderson, J. E. "Hypertension treatment update." International Journal of Cardiology 125 (February 2008): S33. http://dx.doi.org/10.1016/s0167-5273(08)70175-x.

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21

Tobe, Sheldon W., Richard E. Gilbert, Charlotte Jones, Lawrence A. Leiter, Ally P. H. Prebtani, and Vincent Woo. "Treatment of Hypertension." Canadian Journal of Diabetes 42 (April 2018): S186—S189. http://dx.doi.org/10.1016/j.jcjd.2017.10.011.

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22

Poulter, Neil R. "Treatment of Hypertension." Journal of Cardiovascular Pharmacology 18 (1991): S35—S38. http://dx.doi.org/10.1097/00005344-199106182-00008.

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23

Hollenberg, N. K. "Treatment of Hypertension." Journal of Cardiovascular Pharmacology 20 (1992): S29. http://dx.doi.org/10.1097/00005344-199206211-00006.

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24

Hollenberg, N. K. "Treatment of Hypertension." Journal of Cardiovascular Pharmacology 20 (October 1992): S29. http://dx.doi.org/10.1097/00005344-199210001-00006.

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25

Goetze, Jens P., Lasse H. Hansen, Dijana Terzic, and Peter Dall Mark. "Upgrading hypertension treatment." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318, no. 6 (June 1, 2020): R1025—R1026. http://dx.doi.org/10.1152/ajpregu.00086.2020.

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26

Bavry, Anthony A., and Carl J. Pepine. "Treatment of Hypertension." Hypertension 60, no. 2 (August 2012): 281–82. http://dx.doi.org/10.1161/hypertensionaha.112.197632.

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27

Egan, Brent M. "Treatment Resistant Hypertension." Ethnicity & Disease 25, no. 4 (November 10, 2015): 495. http://dx.doi.org/10.18865/ed.25.4.495.

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<p>Treatment resistant hypertension (TRH) is defined by office blood pressure (BP) uncontrolled on ≥3 or controlled on ≥4 antihypertensive medications, preferably at optimal doses and including a diuretic. Apparent (a)TRH is used when optimal therapy, adherence, and measurement artifacts are unknown. Among treated hy­pertensives, ~30% of uncontrolled and 10% of controlled individuals have aTRH, with a higher prevalence in Blacks than other race-ethnicity groups. In ≥50% of aTRH patients, BP measurement artifacts (‘office’ TRH), suboptimal regimens, or suboptimal adher­ence are present, ie, pseudo-resistance. While patients with ‘office’ TRH have fewer cardiovascular events than those with ‘true’ TRH, no evidence confirms that patients with suboptimal regimens or adherence are spared. Averaging several office BPs obtained with an automated monitor can reduce ‘office’ TRH. Home or ambulatory BP monitoring can identify office resistance. Prescribing ≥3 different antihypertensive medication classes, eg, thiazide-type diuret­ic, renin-angiotensin blocker and calcium antagonist at ≥50% of maximum recom­mended doses reasonably defines optimal therapy. Intensifying diuretic therapy, eg, adding an aldosterone antagonist, is effec­tive for many TRH patients who are volume expanded. Clinical information, hemody­namic and renin-guided therapeutics can inform other treatment options. Attention to adverse effects, medication costs, and pill burden can improve adherence and control. Patients with aTRH and suspected second­ary hypertension should be evaluated. Inter­fering substances or medications should be discontinued. These approaches will identify or correct the problem in ~80% of aTRH patients. Referral to a hypertension special­ist and newer therapeutic approaches are options for TRH patients who cannot take or do not respond to optimal therapy. <em>Ethn Dis. </em>2015;25(4):495-498; doi:10.18865/ ed.25.4.495</p>
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28

Kaplan, Norman M. "Treatment of Hypertension." Hypertension 47, no. 1 (January 2006): 10–13. http://dx.doi.org/10.1161/01.hyp.0000196271.03526.50.

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29

Koenig, W., U. Keil, S. Perz, J. Stieber, and A. Döring. "Treatment of hypertension." Klinische Wochenschrift 64, no. 23 (December 1986): 1229–36. http://dx.doi.org/10.1007/bf01734464.

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30

Gilbert, Richard E., Doreen Rabi, Pierre LaRochelle, Lawrence A. Leiter, Charlotte Jones, Richard Ogilvie, Sheldon Tobe, Nadia Khan, Luc Poirier, and Vincent Woo. "Treatment of Hypertension." Canadian Journal of Diabetes 37 (April 2013): S117—S118. http://dx.doi.org/10.1016/j.jcjd.2013.01.033.

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31

Qamar, Arman, and Eugene Braunwald. "Treatment of Hypertension." JAMA 320, no. 17 (November 6, 2018): 1751. http://dx.doi.org/10.1001/jama.2018.16579.

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32

Carey, Robert M., Andrew E. Moran, and Paul K. Whelton. "Treatment of Hypertension." JAMA 328, no. 18 (November 8, 2022): 1849. http://dx.doi.org/10.1001/jama.2022.19590.

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ImportanceHypertension, defined as persistent systolic blood pressure (SBP) at least 130 mm Hg or diastolic BP (DBP) at least 80 mm Hg, affects approximately 116 million adults in the US and more than 1 billion adults worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (coronary heart disease, heart failure, and stroke) and death.ObservationsFirst-line therapy for hypertension is lifestyle modification, including weight loss, healthy dietary pattern that includes low sodium and high potassium intake, physical activity, and moderation or elimination of alcohol consumption. The BP-lowering effects of individual lifestyle components are partially additive and enhance the efficacy of pharmacologic therapy. The decision to initiate antihypertensive medication should be based on the level of BP and the presence of high atherosclerotic CVD risk. First-line drug therapy for hypertension consists of a thiazide or thiazidelike diuretic such as hydrochlorothiazide or chlorthalidone, an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker such as enalapril or candesartan, and a calcium channel blocker such as amlodipine and should be titrated according to office and home SBP/DBP levels to achieve in most people an SBP/DBP target (&amp;lt;130/80 mm Hg for adults &amp;lt;65 years and SBP &amp;lt;130 mm Hg in adults ≥65 years). Randomized clinical trials have established the efficacy of BP lowering to reduce the risk of CVD morbidity and mortality. An SBP reduction of 10 mm Hg decreases risk of CVD events by approximately 20% to 30%. Despite the benefits of BP control, only 44% of US adults with hypertension have their SBP/DBP controlled to less than 140/90 mm Hg.Conclusions and RelevanceHypertension affects approximately 116 million adults in the US and more than 1 billion adults worldwide and is a leading cause of CVD morbidity and mortality. First-line therapy for hypertension is lifestyle modification, consisting of weight loss, dietary sodium reduction and potassium supplementation, healthy dietary pattern, physical activity, and limited alcohol consumption. When drug therapy is required, first-line therapies are thiazide or thiazidelike diuretics, angiotensin-converting enzyme inhibitor or angiotensin receptor blockers, and calcium channel blockers.
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33

Rakugi, Hiromi. "2. Treatment of Complicated Hypertension. 6) Treatment of Elderly Hypertension." Nihon Naika Gakkai Zasshi 100, no. 2 (2011): 413–19. http://dx.doi.org/10.2169/naika.100.413.

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34

FUJISHIMA, MASATOSHI. "Hypertension : progress in diagnosis and treatment. Treatment. Treatment of hypertension with complications. Hypertension complicated by cerebrovascular disorders." Nihon Naika Gakkai Zasshi 79, no. 1 (1990): 65–70. http://dx.doi.org/10.2169/naika.79.65.

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35

KAJIWARA, NAGAO. "Hypertension : progress in diagnosis and treatment. Treatment. Treatment of hypertension with complications. Hypertension accmpanied by diabetes and obesity." Nihon Naika Gakkai Zasshi 79, no. 1 (1990): 54–59. http://dx.doi.org/10.2169/naika.79.54.

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36

KURAMOCHI, MORIO. "Hypertension : progress in diagnosis and treatment. Treatment. Treatment of hypertension with complications. Hypertension complicated by ischemic heart disease and hypertension following myocardial infarction." Nihon Naika Gakkai Zasshi 79, no. 1 (1990): 60–64. http://dx.doi.org/10.2169/naika.79.60.

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37

NISHIO, ICHIRO. "Hypertension : progress in diagnosis and treatment. Treatment. Treatment of hypertension with complications. Hypertension complicated by renal disorders and hypertension due to pregnancy toxemias." Nihon Naika Gakkai Zasshi 79, no. 1 (1990): 71–75. http://dx.doi.org/10.2169/naika.79.71.

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38

MIYAMORI, ISAMU. "Hypertension : progress in diagnosis and treatment. Treatment. Actual status of treatment of secondary hypertension." Nihon Naika Gakkai Zasshi 79, no. 1 (1990): 76–80. http://dx.doi.org/10.2169/naika.79.76.

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39

Anonymous. "Alternate Treatment for Hypertension." Journal of Gerontological Nursing 15, no. 8 (August 1989): 44. http://dx.doi.org/10.3928/0098-9134-19890801-28.

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40

Cohen, Debbie, Raymond Townsend, Mark Miani, and David Bernard. "Treatment Expectations in Hypertension." Disease Management and Health Outcomes 9, no. 11 (2001): 631–40. http://dx.doi.org/10.2165/00115677-200109110-00003.

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41

Motoyoshi, Yaeko. "Treatment for pediatric hypertension." Japanese journal of pediatric nephrology 34, no. 1 (2021): 13–19. http://dx.doi.org/10.3165/jjpn.rv.2021.0001.

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42

Stafylas, Panagiotis C. "Carvedilol in hypertension treatment." Vascular Health and Risk Management 4, no. 1 (2008): 23–30. http://dx.doi.org/10.2147/vhrm.2008.04.01.23.

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43

Sarafidis, Pantelis. "Carvedilol in hypertension treatment." Vascular Health and Risk Management Volume 4 (February 2008): 23–30. http://dx.doi.org/10.2147/vhrm.s1480.

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44

Aronow, Wilbert S. "Treatment of resistant hypertension." Future Cardiology 16, no. 5 (September 2020): 353–56. http://dx.doi.org/10.2217/fca-2020-0038.

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45

&NA;. "Improving treatment of hypertension." Inpharma Weekly &NA;, no. 1220 (January 2000): 6. http://dx.doi.org/10.2165/00128413-200012200-00011.

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46

Taler, Sandra J. "Hypertension: Evaluation and Treatment." Mayo Clinic Proceedings 74, no. 3 (March 1999): 312. http://dx.doi.org/10.4065/74.3.312-a.

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47

Prichard, B. N. C. "Drug Treatment of Hypertension." Drugs 35, Supplement 6 (1988): 40–52. http://dx.doi.org/10.2165/00003495-198800356-00006.

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48

Dandel, Michael. "Apparent Treatment-Resistant Hypertension." JACC: Heart Failure 10, no. 9 (September 2022): 696–97. http://dx.doi.org/10.1016/j.jchf.2022.06.014.

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49

Nussbaumerová, Barbora. "Hypertension treatment in stroke." Praktické lékárenství 17, no. 2 (August 5, 2021): e14-e18. http://dx.doi.org/10.36290/lek.2021.025.

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50

McLean, Keith. "Hypertension: Evaluation and Treatment." Annals of Internal Medicine 129, no. 4 (August 15, 1998): 340. http://dx.doi.org/10.7326/0003-4819-129-4-199808150-00030.

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