Relevant bibliographies by topics / Hyper-plasticity

Academic literature on the topic 'Hyper-plasticity'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Hyper-plasticity"

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Wilson, J. F., V. Lodhia, D. P. Courtney, I. J. Kirk, and J. P. Hamm. "Evidence of hyper-plasticity in adults with Autism Spectrum Disorder." Research in Autism Spectrum Disorders 43-44 (November 2017): 40–52. http://dx.doi.org/10.1016/j.rasd.2017.09.005.

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Sengupta, Soumya, Gargee Bhattacharya, Subhasmita Mohanty, Shubham K. Shaw, Gajendra M. Jogdand, Rohila Jha, Prakash K. Barik, Jyoti R. Parida, and Satish Devadas. "IL-21, Inflammatory Cytokines and Hyperpolarized CD8+ T Cells Are Central Players in Lupus Immune Pathology." Antioxidants 12, no. 1 (January 12, 2023): 181. http://dx.doi.org/10.3390/antiox12010181.

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Systemic lupus erythematous (SLE) is a chronic autoimmune disorder, broadly characterized by systemic inflammation along with heterogeneous clinical manifestations, severe morbidity, moribund organ failure and eventual mortality. In our study, SLE patients displayed a higher percentage of activated, inflamed and hyper-polarized CD8+ T cells, dysregulated CD8+ T cell differentiation, significantly elevated serum inflammatory cytokines and higher accumulation of cellular ROS when compared to healthy controls. Importantly, these hyper-inflammatory/hyper-polarized CD8+ T cells responded better to an antioxidant than to an oxidant. Terminally differentiated Tc1 cells also showed plasticity upon oxidant/antioxidant treatment, but that was in contrast to the SLE CD8+ T cell response. Our studies suggest that the differential phenotype and redox response of SLE CD8+ T cells and Tc1 cells could be attributed to their cytokine environs during their respective differentiation and eventual activation environs. The polarization of Tc1 cells with IL-21 drove hyper-cytotoxicity without hyper-polarisation suggesting that the SLE inflammatory cytokine environment could drive the extreme aberrancy in SLE CD8+ T cells.
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Stahl, Martin, and Alain Stintzi. "Identification of essential genes in C. jejuni genome highlights hyper-variable plasticity regions." Functional & Integrative Genomics 11, no. 2 (February 23, 2011): 241–57. http://dx.doi.org/10.1007/s10142-011-0214-7.

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Flavahan, William A. "Epigenetic plasticity, selection, and tumorigenesis." Biochemical Society Transactions 48, no. 4 (August 14, 2020): 1609–21. http://dx.doi.org/10.1042/bst20191215.

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Epigenetic processes converge on chromatin in order to direct a cell's gene expression profile. This includes both maintaining a stable cell identity, but also priming the cell for specific controlled transitions, such as differentiation or response to stimuli. In cancer, this normally tight control is often disrupted, leading to a wide scale hyper-plasticity of the epigenome and allowing stochastic gene activation and silencing, cell state transition, and potentiation of the effects of genetic lesions. Many of these epigenetic disruptions will confer a proliferative advantage to cells, allowing for a selection process to occur and leading to tumorigenesis even in the case of reversible or unstable epigenetic states. This review seeks to highlight how the fundamental epigenetic shifts in cancer contribute to tumorigenesis, and how understanding an integrated view of cancer genetics and epigenetics may more effectively guide research and treatment.
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Soldatos, D., and S. P. Triantafyllou. "Logarithmic Spin, Logarithmic Rate and Material Frame-Indifferent Generalized Plasticity." International Journal of Applied Mechanics 08, no. 05 (July 2016): 1650060. http://dx.doi.org/10.1142/s1758825116500605.

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In this work, we present a new rate type formulation of large deformation generalized plasticity which is based on the consistent use of the logarithmic rate concept. For this purpose, the basic constitutive equations are initially established in a local rotationally neutralized configuration which is defined by the logarithmic spin. These are then rephrased in their spatial form, by employing some standard concepts from the tensor analysis on manifolds. Such an approach, besides being compatible with the notion of (hyper)elasticity, offers three basic advantages, namely: (i) The principle of material frame-indifference is trivially satisfied. (ii) The structure of the infinitesimal theory remains essentially unaltered. (iii) The formulation does not preclude anisotropic response. A general integration scheme for the computational implementation of generalized plasticity models which are based on the logarithmic rate is also discussed. The performance of the scheme is tested by two representative numerical examples.
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Biundo, F., C. d'Abramo, M. D. Tambini, H. Zhang, D. Del Prete, F. Vitale, L. Giliberto, O. Arancio, and L. D'Adamio. "Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations." Translational Psychiatry 7, no. 8 (August 2017): e1198-e1198. http://dx.doi.org/10.1038/tp.2017.165.

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Abstract TAU mutations are genetically linked to fronto-temporal dementia (FTD) and hyper-phosphorylated aggregates of Tau form neurofibrillary tangles (NFTs) that constitute a pathological hallmark of Alzheimer disease (AD) and FTD. These observations indicate that Tau has a pivotal role in the pathogenesis of neurodegenerative disorders. Tau is cleaved by caspases at Aspartate421, to form a Tau metabolite known as δTau; δTau is increased in AD, due to the hyper-activation of caspases in AD brains. δTau is considered a critical toxic moiety underlying neurodegeneration, which initiates and facilitates NFT formation. As Tau is a therapeutic target in neurodegeneration, it is important to rigorously determine whether δTau is a toxic Tau species that should be pharmacologically attacked. To directly address these questions, we have generated a knock-in (KI) mouse called Tau DN —that expresses a Tau mutant that cannot be cleaved by caspases. Tau DN mice present short-term memory deficits and synaptic plasticity defects. Moreover, mice carrying two mutant Tau alleles show increased total insoluble hyper-phosphorylated Tau in the forebrain. These data are in contrast with the concept that δTau is a critical toxic moiety underlying neurodegeneration, and suggest that cleavage of Tau by caspases represents a negative feedback mechanism aimed to eliminate toxic Tau species. Alternatively, it is possible that either a reduction or an increase in δTau leads to synaptic dysfunction, memory impairments and Tau pathology. Both possibilities will have to be considered when targeting caspase cleavage of Tau in AD therapy.
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Bains, Amarpreet Singh, and Nicolas Schweighofer. "Time-sensitive reorganization of the somatosensory cortex poststroke depends on interaction between Hebbian and homeoplasticity: a simulation study." Journal of Neurophysiology 112, no. 12 (December 15, 2014): 3240–50. http://dx.doi.org/10.1152/jn.00433.2013.

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Together with Hebbian plasticity, homeoplasticity presumably plays a significant, yet unclear, role in recovery postlesion. Here, we undertake a simulation study addressing the role of homeoplasticity and rehabilitation timing poststroke. We first hypothesize that homeoplasticity is essential for recovery and second that rehabilitation training delivered too early, before homeoplasticity has compensated for activity disturbances postlesion, is less effective for recovery than training delivered after a delay. We developed a neural network model of the sensory cortex driven by muscle spindle inputs arising from a six-muscle arm. All synapses underwent Hebbian plasticity, while homeoplasticity adjusted cell excitability to maintain a desired firing distribution. After initial training, the network was lesioned, leading to areas of hyper- and hypoactivity due to the loss of lateral synaptic connections. The network was then retrained through rehabilitative arm movements. We found that network recovery was unsuccessful in the absence of homeoplasticity, as measured by reestablishment of lesion-affected inputs. We also found that a delay preceding rehabilitation led to faster network recovery during the rehabilitation training than no delay. Our simulation results thus suggest that homeoplastic restoration of prelesion activity patterns is essential to functional network recovery via Hebbian plasticity.
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Jiao, Yang, and Jacob Fish. "On the equivalence between the multiplicative hyper-elasto-plasticity and the additive hypo-elasto-plasticity based on the modified kinetic logarithmic stress rate." Computer Methods in Applied Mechanics and Engineering 340 (October 2018): 824–63. http://dx.doi.org/10.1016/j.cma.2018.06.017.

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Albensi, Benedict C., Derek R. Oliver, Justin Toupin, and Gary Odero. "Electrical stimulation protocols for hippocampal synaptic plasticity and neuronal hyper-excitability: Are they effective or relevant?" Experimental Neurology 204, no. 1 (March 2007): 1–13. http://dx.doi.org/10.1016/j.expneurol.2006.12.009.

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van Leeuwe, Tim M., Mark Arentshorst, Gabriel Forn-Cuní, Nicholas Geoffrion, Adrian Tsang, Frank Delvigne, Annemarie H. Meijer, Arthur F. J. Ram, and Peter J. Punt. "Deletion of the Aspergillus niger Pro-Protein Processing Protease Gene kexB Results in a pH-Dependent Morphological Transition during Submerged Cultivations and Increases Cell Wall Chitin Content." Microorganisms 8, no. 12 (December 2, 2020): 1918. http://dx.doi.org/10.3390/microorganisms8121918.

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There is a growing interest in the use of post-fermentation mycelial waste to obtain cell wall chitin as an added-value product. In the pursuit to identify suitable production strains that can be used for post-fermentation cell wall harvesting, we turned to an Aspergillus niger strain in which the kexB gene was deleted. Previous work has shown that the deletion of kexB causes hyper-branching and thicker cell walls, traits that may be beneficial for the reduction in fermentation viscosity and lysis. Hyper-branching of ∆kexB was previously found to be pH-dependent on solid medium at pH 6.0, but was absent at pH 5.0. This phenotype was reported to be less pronounced during submerged growth. Here, we show a series of controlled batch cultivations at a pH range of 5, 5.5, and 6 to examine the pellet phenotype of ΔkexB in liquid medium. Morphological analysis showed that ΔkexB formed wild type-like pellets at pH 5.0, whereas the hyper-branching ΔkexB phenotype was found at pH 6.0. The transition of phenotypic plasticity was found in cultivations at pH 5.5, seen as an intermediate phenotype. Analyzing the cell walls of ΔkexB from these controlled pH-conditions showed an increase in chitin content compared to the wild type across all three pH values. Surprisingly, the increase in chitin content was found to be irrespective of the hyper-branching morphology. Evidence for alterations in cell wall make-up are corroborated by transcriptional analysis that showed a significant cell wall stress response in addition to the upregulation of genes encoding other unrelated cell wall biosynthetic genes.
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Dissertations / Theses on the topic "Hyper-plasticity"

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Jiao, Yang. "On the Equivalence between the Additive Hypo-Elasto-Plasticity and Multiplicative Hyper-Elasto-Plasticity Models and Adaptive Propagation of Discontinuities." Thesis, 2018. https://doi.org/10.7916/D8JW9SBC.

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Ductile and brittle failure of solids are closely related to their plastic and fracture behavior, respectively. The two most common energy dissipation mechanisms in solids possess distinct kinematic characteristics, i.e. large strain and discontinuous displacement, both of which pose challenges to reliable, efficient numerical simulation of material failure in engineering structures. This dissertation addresses the reliability and efficiency issues associated with the kinematic characteristics of plasticity and fracture. At first, studies are conducted to understand the relation between two well recognized large strain plasticity models that enjoy widespread popularity in numerical simulation of plastic behavior of solids. These two models, termed the additive hypo-elasto-plasticity and multiplicative hyper-elasto-plasticity models, respectively, are regarded as two distinct strategies for extending the classical infinitesimal deformation plasticity theory into the large strain regime. One of the most recent variants of the additive models, which features the logarithmic stress rate, is shown to give rise to nonphysical energy dissipation during elastic unloading. A simple modification to the logarithmic stress rate is accordingly made to resolve such a physical inconsistency. This results in the additive hypo-elasto-plasticity models based on the kinetic logarithmic stress rate in which energy dissipation-free elastic response is produced whenever plastic flow is absent. It is then proved that for isotropic materials the multiplicative hyper-elasto-plasticity models coincide with the additive ones if a newly discovered objective stress rate is adopted. Such an objective stress rate, termed the modified kinetic logarithmic rate, reduces to the kinetic logarithmic rate in the absence of strain-induced anisotropy which is characterized as kinematic hardening in the present dissertation. In the second part of the dissertation, the computational complexity of finite element analysis of the onset and propagation of interface cracks in layered materials is addressed. The study is conducted in the context of laminated composites in which interface fracture (delamination) is a dominant failure mode. In order to eliminate the complexities of remeshing for constant initiation and propagation of delamination, two hierarchical approaches, the extended finite element method (XFEM) and the s-version of the finite element method (s-method) are studied in terms of their effectiveness in representing displacement discontinuity across delaminated interfaces. With one single layer of 20-node serendipity solid elements resolving delamination-free response of the layered materials, it is proved that the delamination representations based on the s-method and the XFEM result in the same discretization space as the conventional non-hierarchical ply-by-ply approach which employs one layer of solid elements for each ply as well as double nodes on delaminated interfaces. Delamination indicators based on the s-method representation of delamination are then proposed to detect the onset and propagation of delamination. An adaptive methodology is accordingly developed in which the s-method displacement field enrichment for delamination is adaptively added to interface areas with high likelihood of delamination. Numerical examples show that the computational cost of the adaptive s-method is significantly lower than that incurred by the conventional ply-by-ply approach despite the fact that the two approaches produce practically identical results.
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Book chapters on the topic "Hyper-plasticity"

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Kuhn, G. "A Total-Lagrangian Fbem-Approach for Hyper-Elasticity and Plasticity at Finite Strains." In IABEM Symposium on Boundary Integral Methods for Nonlinear Problems, 139–44. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5706-3_22.

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Gandour, Mhemmed. "Abiotic Stress Response in Brachypodium." In Plant Stress Physiology - Perspectives in Agriculture [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102000.

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Understanding the mechanisms of physiological response in plants is crucial to building sustainable agriculture, especially under the current worldwide climate and environmental crises. Thus, plants that successfully acclimate to stress can decrease growth under stressful conditions. Brachypodium, an undomesticated grass species with close evolutionary relationships to wheat and barley, is a promising model organism of crop research. It can grow under various conditions and possess specific adaptations or tolerance mechanisms. Hence, it promises to greatly accelerate the process of gene discovery in the grasses and to serve as bridges in the exploration of panicoid and pooid grasses, arguably two of the most important clades of plants from a food security perspective. Brachypodium could hence efficaciously acclimate to the drought, salinity, cold, heat, and nutrient stress variations by reversible hypo (hyper)-activation of specific genes or sustaining transcription states as well as by reducing growth and osmotic adjustment. Nonetheless, B. stacei and B. hybridum have more plasticity and more adaptiveness than B. distachyon to abiotic stress. This review will describe advancements in knowledge of the physiological and metabolic adjustments that are needed for abiotic stress tolerance.
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Marwaha, Lovleen. "The Queen Honey Bee: Introduction, Development, Pheromones, Mating, and Role in the Colony." In The Polyandrous Queen Honey Bee: Biology and Apiculture, 1–34. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815079128112010002.

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Apis mellifera (2n=32), commonly known as the European honey bee or the Western honey bee, is a eusocial insect. Each honey bee colony is a composite unit of thousands of bees, with three different castes: a polyandrous reproductively active queen; thousands of workers; and a few hundred drones. The queen and the workers represent the female caste that develops from fertilized eggs, whereas the drones are male bees formed from unfertilized or fertilized eggs. In the case of the female honey bees, the phenomenon of polyphenism can be easily highlighted, which is the developmental plasticity of the same genomic contents to express differently as per environmental cues. During the queen larval developmental phase, the exclusive diet is royal jelly, which induces hyper-secretion of juvenile and ecdysone hormones that ultimately cause sequential activation of certain genetic elements, specifically after 3rd instar onward. For the worker honey bee larvae, initially, the diet includes royal jelly exclusively, followed by honey, pollen grains, and worker jelly, which collectively direct development toward the worker caste. Furthermore, for harmonious social interaction, the queen secretes certain volatile chemical bouquets including 9- ODA(2E)-9-oxodecenoic acid), 9-HDA (9-hydroxy-(E)-2-decenoic acid), 10-HDA (10-hrdroxy-2-decenoic acid), HVA (4-hydroxy-3-methoxyphenylethanol), HOB (Methyl-p-hydroxybenzoate), 10-HDAA (10-hydroxydecanoic acid), OLA (oligolactide), methyl oleate, decyl decanoate, linolenic acid, coniferyl alcohol, cetyl alcohol, etc. The concerned pheromones facilitate the regulation of workers' behavior; workers' ovarian suppression; retinue control; overall worker’s development modulation; colonial product production; swarming tendency; pseudo-queen formation suppression; mating, etc. The queen honey bee is polyandrous, as she mates with many drones during the nuptial flight in 'Drone Congregation Areas (DCA)’, within about 2 weeks of her post-emergence. This chapter provides a comprehensive review of the polyandrous queen honey bee; her synchronous developmental phases; her pheromone dominance; her regulation and coordination of colonies; her mating preference and habits; and her role in a composite hive. Subsequent chapters provide an elaborative view of different aspects of the queen honey bees' life cycle.
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Conference papers on the topic "Hyper-plasticity"

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Emami Azadi, M. Reza. "Reliability Study of a North-Sea Jack-Up Under Action of Wave-in-Deck, SH- and SV-Seismic Waves Considering Spud-Can-Soil Interaction." In ASME 2010 29th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/omae2010-20003.

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In the current study, the effect of spud-can-soil interaction modeling as well as wave load modeling and sea-state on the reliability index of a three-leg North-sea drilling type jack-up platform is studied. The platform has operated in depths of 95–105m and its three main legs modeled as pipe elements and the main deck is also modeled using general beam and also shell/plate elements. The spud-can foundation is modeled using elasto-plastic, hyper-elastic springs as well as spud-model of usfos using a general non-associative plasticity model. The wave-in-deck load is considered using API-RP2A [1], Shell and Statoil models. The SH and SV-seismic waves are considered separately at spud-can base as scaled. The preliminary results of this study showed that the annual probability of failure for the Jack-up platform is significantly affected by the random-sea and wave-in-deck modeling as well as spud-can-soil interaction modeling and soil parameters. Study of importance factors indicated that more refined spud-can-soil interaction modeling as well as wave-in-deck load modeling might improve the calculation models and hence reduce their associated uncertainty in reliability analysis of jack-up type platform.
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Chieslar, J. D. "A Comprehensive Constitutive Model Solver." In 56th U.S. Rock Mechanics/Geomechanics Symposium. ARMA, 2022. http://dx.doi.org/10.56952/arma-2022-0865.

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ABSTRACT: The object-oriented software concept is applied to material mechanics calculations. The result is a comprehensive predictor-corrector which has been employed to solve virtually all of the constitutive exercises in a mature, general-purpose, finite element program. In addition to updating internal variables consistent with global inputs (corrector), the software also produces consistent material tangents (predictor), without resort to formulae. Coupled mechanical-thermal-porous flow problems are addressed as well as compound mechanical responses: creep-plasticity, creep-damage, etc. Material and spatial coordinate transformations are incorporated as well as transformation to and from local material axes. Internal calculations may be undertaken in either spatial or material coordinates, depending upon the native definition. Even viscoelasticity and hyper-viscoelasticity, via Prony series, are efficiently handled by the sparse solver. A tool to exercise any material model, simulating global inputs, is incorporated. Historical plots may be produced and inputs may be cyclical or otherwise simulate complex histories. This is accomplished by using PostScript operators. 1 INTRODUCTION It is perhaps most common in commercial modeling software that each constitutive model is self-contained, that is, each solves the responses and forms the material tangents (algorithm-oriented software design). There is much advantage to be gained by employing a uniform solution/tangent formation strategy for all material models. Indeed, this is the subject of this communication. At first examination, this may seem incongruous considering the different solution strategies employed for different models. For example visco-elasticity, via a prony series, is most often solved by a recursive solution scheme, whereas plasticity would be solved via a Newton-Raphson scheme. Of course, for simplified versions of these models, a forward difference integration scheme is employed, Flac3d, for example. If the constitutive model is algorithmically nonlinear, it is tacitly assumed that any path dependence is captured by taking small time/load steps. The highly nonlinear nature of strain-hardening models, however, generally requires iteration at the constitutive level. This is generally not supported in forward difference programs so the material models in these codes tend to be relatively simple.
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Xu, Lei, Theocharis Baxevanis, and Dimitris Lagoudas. "A Three-Dimensional Constitutive Model for Polycrystalline Shape Memory Alloys Under Large Strains Combined With Large Rotations." In ASME 2018 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/smasis2018-8050.

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Shape Memory Alloys (SMAs), known as an intermetallic alloys with the ability to recover its predefined shape under specific thermomechanical loading, has been widely aware of working as actuators for active/smart morphing structures in engineering industry. Because of the high actuation energy density of SMAs, compared to other active materials, structures integrated with SMA-based actuators has high advantage in terms of tradeoffs between overall structure weight, integrity and functionality. The majority of available constitutive models for SMAs are developed within infinitesimal strain regime. However, it was reported that particular SMAs can generate transformation strains nearly up to 8%–10%, for which the adopted infinitesimal strain assumption is no longer appropriate. Furthermore, industry applications may require SMA actuators, such as a SMA torque tube, undergo large rotation deformation at work. Combining the above two facts, a constitutive model for SMAs developed on a finite deformation framework is required to predict accurate response for these SMA-based actuators under large deformations. A three-dimensional constitutive model for SMAs considering large strains with large rotations is proposed in this work. This model utilizes the logarithmic strain as a finite strain measure for large deformation analysis so that its rate form hypoelastic constitutive relation can be consistently integrated to deliver a free energy based hyper-elastic constitutive relation. The martensitic volume fraction and the second-order transformation strain tensor are chosen as the internal state variables to characterize the inelastic response exhibited by polycrystalline SMAs. Numerical experiments for basic SMA geometries, such as a bar under tension and a torque tube under torsion are performed to test the capabilities of the newly proposed model. The presented formulation and its numerical implementation scheme can be extended in future work for the incorporation of other inelastic phenomenas such as transformation-induced plasticity, viscoplasticity and creep under large deformations.
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"Preparation of papers for MHS 2017 28th 2017 international symposium on micro-nanomechatronics and human science (From micro & nano scale systems to robotics & mechatronics systems) Symposium on "hyper bio assembler for 3D cellular system innovation" grant-in-aid for scientific research on innovative areas, MEXT, Japan symposium on "understanding brain plasticity on body representation to promote their adaptive functions" grant-in-aid for scientific research on innovative areas, MEXT, Japan." In 2017 International Symposium on Micro-NanoMechatronics and Human Science (MHS). IEEE, 2017. http://dx.doi.org/10.1109/mhs.2017.8305279.

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