Relevant bibliographies by topics / Hydroxyapatite targeting

Academic literature on the topic 'Hydroxyapatite targeting'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Hydroxyapatite targeting"

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Xiong, Hui, Shi Du, Ping Zhang, Zhijie Jiang, Jianping Zhou, and Jing Yao. "Primary tumor and pre-metastatic niches co-targeting “peptides-lego” hybrid hydroxyapatite nanoparticles for metastatic breast cancer treatment." Biomaterials Science 6, no. 10 (2018): 2591–604. http://dx.doi.org/10.1039/c8bm00706c.

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Lalatonne, Y., M. Monteil, H. Jouni, J. M. Serfaty, O. Sainte-Catherine, N. Lièvre, S. Kusmia, P. Weinmann, M. Lecouvey, and L. Motte. "Superparamagnetic Bifunctional Bisphosphonates Nanoparticles: A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic." Journal of Osteoporosis 2010 (2010): 1–7. http://dx.doi.org/10.4061/2010/747852.

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A bone targeting nanosystem is reported here which combined magnetic contrast agent for Magnetic Resonance Imaging (MRI) and a therapeutic agent (bisphosphonates) into one drug delivery system. This new targeting nanoplatform consists of superparamagneticγFe2O3nanoparticles conjugated to 1,5-dihydroxy-1,5,5-tris-phosphono-pentyl-phosphonic acid (di-HMBPs) molecules with a bisphosphonate function at the outer of the nanoparticle surface for bone targeting. The as-synthesized nanoparticles were evaluated as a specific MRI contrast agent by adsorption study onto hydroxyapatite and MRI measurment. The strong adsorption of the bisphosphonates nanoparticles to hydroxyapatite and their use as MRIT2∗contrast agent were demonstrated. Cellular tests performed on human osteosarcoma cells (MG63) show thatγFe2O3@di-HMBP hybrid nanomaterial has no citoxity effect in cell viability and may act as a diagnostic and therapeutic system.
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Lee, Kyung Kwan, Jae-Geun Lee, Chul Soon Park, Sun Hyeok Lee, Naren Raja, Hui-suk Yun, Jeong-Soo Lee, and Chang-Soo Lee. "Bone-targeting carbon dots: effect of nitrogen-doping on binding affinity." RSC Advances 9, no. 5 (2019): 2708–17. http://dx.doi.org/10.1039/c8ra09729a.

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Kim, Jong-Won, Kyung-Kwan Lee, Kyoung-Woo Park, Moonil Kim, and Chang-Soo Lee. "Genetically Modified Ferritin Nanoparticles with Bone-Targeting Peptides for Bone Imaging." International Journal of Molecular Sciences 22, no. 9 (May 3, 2021): 4854. http://dx.doi.org/10.3390/ijms22094854.

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Bone homeostasis plays a major role in supporting and protecting various organs as well as a body structure by maintaining the balance of activities of the osteoblasts and osteoclasts. Unbalanced differentiation and functions of these cells result in various skeletal diseases, such as osteoporosis, osteopetrosis, and Paget’s disease. Although various synthetic nanomaterials have been developed for bone imaging and therapy through the chemical conjugation, they are associated with serious drawbacks, including heterogeneity and random orientation, in turn resulting in low efficiency. Here, we report the synthesis of bone-targeting ferritin nanoparticles for bone imaging. Ferritin, which is a globular protein composed of 24 subunits, was employed as a carrier molecule. Bone-targeting peptides that have been reported to specifically bind to osteoblast and hydroxyapatite were genetically fused to the N-terminus of the heavy subunit of human ferritin in such a way that the peptides faced outwards. Ferritin nanoparticles with fused bone-targeting peptides were also conjugated with fluorescent dyes to assess their binding ability using osteoblast imaging and a hydroxyapatite binding assay; the results showed their specific binding with osteoblasts and hydroxyapatite. Using in vivo analysis, a specific fluorescent signal from the lower limb was observed, demonstrating a highly selective affinity of the modified nanoparticles for the bone tissue. These promising results indicate a specific binding ability of the nanoscale targeting system to the bone tissue, which might potentially be used for bone disease therapy in future clinical applications.
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Kupikowska-Stobba, Barbara, and Mirosław Kasprzak. "Fabrication of nanoparticles for bone regeneration: new insight into applications of nanoemulsion technology." Journal of Materials Chemistry B 9, no. 26 (2021): 5221–44. http://dx.doi.org/10.1039/d1tb00559f.

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This review discusses nanoemulsion technology as a tool for fabrication of nanoparticles for bone regeneration applications including hydroxyapatite nanoparticles, polymer nanoparticles for drug/biomolecule delivery and bone-targeting nanoparticles.
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Vaingankar, Sucheta M., Thomas A. Fitzpatrick, Kristen Johnson, James W. Goding, Michele Maurice, and Robert Terkeltaub. "Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1." American Journal of Physiology-Cell Physiology 286, no. 5 (May 2004): C1177—C1187. http://dx.doi.org/10.1152/ajpcell.00320.2003.

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The ectonucleoside pyrophosphatase phosphodiesterase 1 (NPP1/PC-1) is a member of the NPP enzyme family that is critical in regulating mineralization. In certain mineralizing sites of bone and cartilage, membrane-limited vesicles [matrix vesicles (MVs)] provide a sheltered internal environment for nucleation of calcium-containing crystals, including hydroxyapatite. MV formation occurs by budding of vesicles from the plasma membrane of mineralizing cells. The MVs are enriched in proteins that promote mineralization. Paradoxically, NPP1, the type II transmembrane protein that generates the potent hydroxyapatite crystal growth inhibitor inorganic pyrophosphate (PPi), is also enriched in MVs. Although osteoblasts express NPP1, NPP2, and NPP3, only NPP1 is enriched in MVs. Therefore, this study uses mineralizing human osteoblastic SaOS-2 cells, a panel of NPP1 mutants, and NPP1 chimeras with NPP3, which does not concentrate in MVs, to investigate how NPP1 preferentially targets to MVs. We demonstrated that a cytosolic dileucine motif (amino acids 49–50) was critical in localizing NPP1 to regions of the plasma membrane that budded off into MVs. Moreover, transposition of the NPP1 cytoplasmic dileucine motif and flanking region (AAASLLAP) to NPP3 conferred to NPP3 the ability to target to the plasma membrane and, subsequently, concentrate in MVs. Functionally, the cytosolic tail dileucine motif NPP1 mutants lost the ability to support MV PPi concentrations and to suppress calcification. The results identify a specific targeting motif in the NPP1 cytosolic tail that delivers PPi-generating NPP activity to osteoblast MVs for control of calcification.
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Albayati, Zaineb A. F., Manjula Sunkara, Suzannah M. Schmidt-Malan, Melissa J. Karau, Andrew J. Morris, James M. Steckelberg, Robin Patel, et al. "Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone." Antimicrobial Agents and Chemotherapy 60, no. 3 (December 14, 2015): 1865–68. http://dx.doi.org/10.1128/aac.01609-15.

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We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.
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Song, Jiaming, Naiyu Cui, Xuran Mao, Qixuan Huang, Eui-Seok Lee, and Hengbo Jiang. "Sorption Studies of Tetracycline Antibiotics on Hydroxyapatite (001) Surface—A First-Principles Insight." Materials 15, no. 3 (January 21, 2022): 797. http://dx.doi.org/10.3390/ma15030797.

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Owing to the limitations of traditional systemic drug delivery in the treatment of bone diseases with side effects on normal cells, the selection of materials with high affinities for bones, as targeting ligands to modify drug carriers, has become an important research topic. Tetracyclines (TCs) have an adsorption effect on hydroxyapatite (HAp). Thus, they can be used as bone-targeting ligands and combined with drug carriers. In this study, density functional theory is used to analyze the interaction mechanism of TC, oxytetracycline (OTC), chlortetracycline, and HAp. We calculate the electrostatic potential (ESP) and molecular orbitals to predict the possible binding sites of TCs on the HAp surface. The adsorption energy is used to compare the affinities of the three TCs to HAp. An independent gradient model analysis is performed to study the weak interaction between TCs and HAp. The coordination bond between TCs and the HAp surface is evaluated by conducting a charge density difference analysis. The results show that OTC has the highest affinity to HAp because the introduction of hydroxyl groups change the adsorption configuration of OTC. Thus, OTC adsorbed on HAp in a broken-line shape exposes more binding sites. This study provides a theoretical basis for TCs as bone-targeting ligands in treating bone diseases and in improving the safety of treatment by selecting different bone-targeting ligands.
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Soriano‐Souza, Carlos, Helder Valiense, Elena Mavropoulos, Victor Martinez‐Zelaya, Andrea Machado Costa, Adriana T. Alves, Mariana Longuinho, et al. "Doxycycline containing hydroxyapatite ceramic microspheres as a bone‐targeting drug delivery system." Journal of Biomedical Materials Research Part B: Applied Biomaterials 108, no. 4 (May 2020): 1351–62. http://dx.doi.org/10.1002/jbm.b.34484.

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Goswami, Moushmi, Pavni Rekhi, Mousumi Debnath, and Seeram Ramakrishna. "Microbial Polyhydroxyalkanoates Granules: An Approach Targeting Biopolymer for Medical Applications and Developing Bone Scaffolds." Molecules 26, no. 4 (February 6, 2021): 860. http://dx.doi.org/10.3390/molecules26040860.

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Microbial polyhydroxyalkanoates (PHA) are proteinaceous storage granules ranging from 100 nm to 500 nm. Bacillus sp. serve as unique bioplastic sources of short-chain length and medium-chain length PHA showcasing properties such as biodegradability, thermostability, and appreciable mechanical strength. The PHA can be enhanced by adding functional groups to make it a more industrially useful biomaterial. PHA blends with hydroxyapatite to form nanocomposites with desirable features of compressibility. The reinforced matrices result in nanocomposites that possess significantly improved mechanical and thermal properties both in solid and melt states along with enhanced gas barrier properties compared to conventional filler composites. These superior qualities extend the polymeric composites’ applications to aggressive environments where the neat polymers are likely to fail. This nanocomposite can be used in different industries as nanofillers, drug carriers for packaging essential hormones and microcapsules, etc. For fabricating a bone scaffold, electrospun nanofibrils made from biocomposite of hydroxyapatite and polyhydroxy butyrate, a form of PHA, can be incorporated with the targeted tissue. The other methods for making a polymer scaffold, includes gas foaming, lyophilization, sol–gel, and solvent casting method. In this review, PHA as a sustainable eco-friendly NextGen biomaterial from bacterial sources especially Bacillus cereus, and its application for fabricating bone scaffold using different strategies for bone regeneration have been discussed.
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Dissertations / Theses on the topic "Hydroxyapatite targeting"

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Miguel, Martínez de Aragón Laura de. "Nanoparticules multifonctionnelles de PBLG destinées au ciblage et à la délivrance d’anticancéreux aux tissus osseux." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA114829/document.

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Des nanoparticules multifonctionnelles polymères, préparées par auto-assemblage de plusieurs dérivés du poly (L-glutamate de gamma-benzyle) (PBLG), ont été conçues afin d’assurer le ciblage des tissus osseux et la libération contrôlée de molécules actives. Des propriétés d'attachement aux tissus osseux leur ont été conférées par la présentation en surface de différents ligands ostéotropes, l'alendronate et l' acide poly(glutamique), seuls ou en combinaison. Leur affinité pour les tissus osseux a été évaluée in vivo ainsi que leur distribution fine dans ces tissus. Par ailleurs, des propriétés anticancéreux ont été conférées aux nanoparticules grâce à un mécanisme originale d’association du cisplatin par complexation. Le procédé mis en œuvre permet d’obtenir des cinétiques de libération très progressives de dérivés actifs du platine et déclenchée par la présence des ions chlorure. Enfin, leur cytotoxicité a été mesurée. Cette stratégie constitue donc une approche prometteuse en vue d’améliorer le traitement des métastases osseuses
Multifunctional bone targeted polymeric nanoparticles prepared by self-assembly of several poly(gamma-benzyl-L-glutamate) (PBLG) derivates have been developed. Their bone binding properties were provided by two different osteotropic moieties, alendronate or/and poly(glutamic acid) exposed on the nanoparticle surface. Their affinity for bone tissues has been evaluated in vitro, ex vivo and in vivo, including their detailed distribution in bone tissues structures. Further, in view of bone cancer therapeutics, nanoparticles were provided with anticancer properties thanks to the complexation of cisplatin, which leaded to very well controlled release properties. Finally, cytotoxicity were studied. Therefore, this strategy constitute a promising approach for the improvement of bone cancer therapeutics
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Lin, Jing-Yun, and 林靖昀. "HER-2 Antibody-Conjugated Magnetic Mesoporous Hydroxyapatite Nanocrystal for Breast Cancer Targeting and Chemohyperthermia." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/93625160280357103125.

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碩士
大同大學
材料工程學系(所)
103
In this study, the result demonstrated that iron doped hydroxyapatite nanocrystal with mesoporous structure was successfully prepared through one step route. mesoporous materials have gained enhanced interest with particular attention as drug storage and release hosts due to their higher surface area(54 m2/g) and unique textural properties. This material exhibits rod-like, crystalline structure, which is suitable for drug (Doxorubicin) release as drug carrier and prolong the release time(130 hr).Due to some tumor may overexpressing HER-2 genes, so it can immobilization HER-2 antibody onto MPmHAp surface to active targeting tumor cell and through receptor-mediated endocytosis, it can enhance cell uptake of HER2-MPmHAp(341.1 pg/cell). Finally, it can using chemohyperthermia that hyperthermia improves the antitumor effect of some chemotherapeutic agents.
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