Academic literature on the topic 'Hydrazine'

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Journal articles on the topic "Hydrazine"

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Ananthi, Vadamalai, Kaliyaraj Rajalakshmi, Inbasekaran Muthuvel, and Ganesamoorthy Thirunarayanan. "Solid acidic FeCl3/Bentonite catalyzed solvent-free condensation: Synthesis, spectral studies and antimicrobial activities of some aryl hydrazine Schiff’s bases." Annales Universitatis Mariae Curie-Sklodowska, sectio AA – Chemia 71, no. 2 (April 3, 2017): 127. http://dx.doi.org/10.17951/aa.2016.71.2.127.

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<p>Some aryl hydrazide derivatives have been synthesized including 1-(3-chloro-4-nitrophenyl)-2-(3-substituted benzylidene) hydrazines by FeCl<sub>3</sub>/Bentonite catalyzed solvent-free condensation of substituted phenyl hydrazine and aldehydes under microwave irradiation. The yields of the hydrazides are more than 70%. The synthesized hydrazides are characterized by the physical constants, micro analysis and spectroscopic data. Effect of catalyst, solvent effect substituent effect and optimization of the catalyst was studied by the percentage of isolated yields. From the catalyst optimization, the present study catalyst gave the better yield of products. The antimicrobial activities of all synthesized of 1-(3-chloro-4-nitrophenyl)-2-(3-substituted benzylidene) hydrazines have been evaluated using Bauer-Kirby disc diffusion method.</p>
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Ekram Abdullah Basheer, Kalid Matny Al-jaanaby, and Feras Shauki Al-joboury. "Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin." Tikrit Journal of Pure Science 20, no. 5 (February 10, 2023): 84–95. http://dx.doi.org/10.25130/tjps.v20i5.1244.

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In this paper, the preparation a number of heterocyclic compounds five membered rings like oxadiazole, imidazolidine, thiozolidine, tetrazole, azetidine 2-on. Hydrazide (1) was synthesized from the reaction of levofloxacin with hydrazine hydrate. Hydrazone compounds (2-9) were synthesized from the reaction (1) with a number of aldehydes, and 3-acetyl-1,3,4-oxadiazol (10-17) was prepared from the reaction of hydrazones (2-9) with acetic anhydride, 5-oxo-2-aryl imadazoldine derivative (18-25) were prepared from the reaction of hydrazone derivatives (2-9) with glycine, while the reaction of hydrazone with thioglygolic acid gave 4-oxo-2-aryl-thiozolidine (26-33),tetrazole derivative(34-41)prepared from the reaction of hydrazone(2-9) with sodium azide in tetrahyro furan.azetidine-2-on(42-49)with chloro acetyl chloride in DMF and and in the presence of triethyl amine these compounds were characterized on bases of spectral and physical data.
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Al-Shiekh, Mariam A., Hanady Y. Medrassi, Mohamed H. Elnagdi, and Ebtisam A. Hafez. "Substituted Hydrazonals as Building Blocks in Heterocyclic Synthesis: A New Route to Arylhydrazonocinnolines." Journal of Chemical Research 2007, no. 7 (July 2007): 432–36. http://dx.doi.org/10.3184/030823407x234617.

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2-heteroylhydrazonopropanals 2a–e and 3-oxo-2-arylhydrazonopropanals 2f–k were prepared via coupling of enaminones 1 with aromatic diazonium salts. Compounds 2a–c condensed with hydrazine hydrate to yield the corresponding hydrazones 3a–c which afford on cyclisation the cinnoline derivatives 6a–c, while condensation of 2g, j with hydrazine hydrate directly yielded the pyrazole derivatives 4g–j. Condensation of 2a–c, f, g with phenyl hydrazine gave the corresponding phenyl hydrazone derivatives 7a–c, f, g. Structures of 2a, h and 3a were assessed by single crystal X-ray analyses.
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Prateeptongkum, Saisuree, Nongnaphat Duangdee, and Wiratchanee Mahavorasirikul. "Evaluation of Cytotoxicity and Apoptosis Induced by Coumarin Hydrazide-Hydrazone Derivatives in Human Hepatocellular Carcinoma Cell Line." Trends in Sciences 21, no. 7 (May 1, 2024): 7628. http://dx.doi.org/10.48048/tis.2024.7628.

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Coumarin and aryl hydrazide-hydrazone have attracted our attention due to their vast biological properties. Previous studies suggested that coumarin-tethered aryl hydrazide-hydrazone showed potent activities against HepG2. In the present study, we investigated the cytotoxic potency of the coumarin derivatives 1 - 3 to compare with coumarin hydrazine-hydrazone hybrids 4 and 5 against hepatocellular carcinoma HepG2 and LH86 cell lines. Among the tested coumarins, hybrids 4 and 5 showed highly potent activity against HepG2 with IC50 values of 17.82 ± 2.79 and 7.87 ± 0.88 𝜇g/mL, respectively. The hybrid 4 also showed the strongest activity against LH86 cell line with IC50 values of 48.32 ± 2.64 𝜇g/mL. Further, we have studied the mechanism of action of the hybrid compounds 4 and 5 in HepG2 cells via the flow-cytometry analysis and the activation of the caspase-3 and caspase-7. The results showed that hybrids 4 and 5 obviously inhibited the proliferation of HepG2 cell line through inducing apoptosis. HIGHLIGHTS Focusing on coumarin and aryl hydrazide-hydrazone possess significant biological properties. We reported the preparation of coumarin hydrazine-hydrazone hybrids and evaluated their effects against hepatocellular carcinoma cell lines HepG2 and LH86. The hybrid compounds exhibited high potency against HepG2 and LH86. Flow-cytometry and caspase-3/7 expression analysis revealed that the hybrid compounds induced apoptosis in HepG2 cells. GRAPHICAL ABSTRACT
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Ibtehal K. Abdullah and Meaad K. Buniya. "Preparation and Identification of some heterocyclic compounds from cyano compounds." Tikrit Journal of Pure Science 20, no. 5 (February 10, 2023): 96–105. http://dx.doi.org/10.25130/tjps.v20i5.1245.

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This article included prepared cyano acetic acid hydrazid from interaction cyano ethylacetate with hydrate hydrazen, and interaction with 2- acytel thiophene and 2- acytelpyridine it will formation of hydrazide- hydrazone derivative (I, II), and through the undergo the compounds (I,II) for chain of interactions with different chemical materials then enclosed cyclo formed derivative of (arylidene ,coumarin , aryl hydrazon , thiophene ) . Prepared compounds have been studied and Identification by physical and spectral means.
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Agili, Fatimah. "Novel Hydrazide Hydrazone Derivatives as Antimicrobial Agents: Design, Synthesis, and Molecular Dynamics." Processes 12, no. 6 (May 22, 2024): 1055. http://dx.doi.org/10.3390/pr12061055.

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Ester 2 was produced by reacting thiourea derivative 1 with ethyl 2-chloro-3-oxobutanoate in MeOH containing piperidine. Hydrazide 3 was produced by reacting the latter ester with hydrazine hydrate in EtOH at reflux. By reacting hydrazide 3 with aromatic/heterocyclic aldehydes, twelve derivatives of hydrazide hydrazone 5a–l were produced. Spectral measurements and elemental analysis verified the molecular structure. Compounds 2, 5a, 5c, 5d, and 5f had strong effects on all the pathogenic bacterial strains according to an evaluation of the antimicrobial qualities of the synthetic compounds. With inhibitory zone diameters ranging from 16 to 20.4 mm, hydrazide hydrazone 5f exhibited the strongest activity. Additionally, the minimum inhibitory concentration (MIC) was assessed. The best outcomes were found with hydrazones 5c and 5f. For B. subtilis, the MIC of 5c was 2.5 mg/mL. For E. coli and K. pneumoniae, the MIC of 5f was 2.5 mg/mL. The molecular mechanics-generalized born surface area (MM/GBSA) was utilized to compute binding free energies via a molecular dynamics simulation analysis of the most active compounds, 5f and 5c. Moreover, computational analyses demonstrated that 5f had a substantial affinity for the active site of DNA gyrase B, suggesting that this compound could be a strong platform for new structure-based design efforts.
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Wu, Shouting, Xi Liang, Fang Luo, Hua Liu, Lingyi Shen, Xianjiong Yang, Yali Huang, et al. "Synthesis, Crystal Structure and Bioactivity of Phenazine-1-carboxylic Acylhydrazone Derivatives." Molecules 26, no. 17 (September 1, 2021): 5320. http://dx.doi.org/10.3390/molecules26175320.

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A phenazine-1-carboxylic acid intermediate was synthesized from the reaction of aniline and 2-bromo-3-nitro-benzoic acid. It was then esterified and reacted with hydrazine hydrate to afford phenazine-1-carboxylic hydrazine. Finally, 10 new hydrazone compounds 3a–3j were obtained by the condensation reaction of phenazine-1-carboxylic acid hydrazide and the respective aldehyde-containing compound. The structures were characterized by 1H and 13C NMR spectroscopy, MS and single crystal X-ray diffraction. The antitumor activity of the target compounds in vitro (HeLa and A549) was determined by thiazolyl blue tetrazolium bromide. The results showed that compound (E)-N′-(2-hydroxy-4-(2-(piperidine-1-yl) ethoxy) benzyl) phenazine-1-carbonyl hydrazide 3d exhibited good cytotoxic activity.
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Geschwentner, Michael, Gernot Elter, and Anton Meller. "Supermesityl-substituierte Hydrazinoborane / Supermesityl-Substituted Hydrazinoboranes." Zeitschrift für Naturforschung B 49, no. 4 (April 1, 1994): 459–64. http://dx.doi.org/10.1515/znb-1994-0405.

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Difluoro(supermesityl)borane reacts with monolithiated hydrazines to give the correspond­ ing fluoroborylated hydrazines 1a-c , which could not be dehydrofluorinated to yield definite products. From dilithiated hydrazine the 1,2-borylated species 2 was obtained. The fluoro-borylhydrazones 3a-3d prepared in an analogous way, by dehydrofluorination with tert-butyllithium, led to 5-, 6-and 7-membered boron nitrogen heterocycles depending upon the substituents of the hydrazones.
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Lerner, Hans-Wolfram, Nils Wiberg, Michael Bolte, H. Nöth, and J. Knizek. "Supersilyliertes Ammoniak und supersilyliertes Hydrazin: Synthese, Struktur und Eigenschaften / Supersilyl Ammonia and Supersilyl Hydrazine: Synthesis, Structure and Properties." Zeitschrift für Naturforschung B 57, no. 2 (February 1, 2002): 177–82. http://dx.doi.org/10.1515/znb-2002-0208.

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An excellent supersilylation agent, supersilyl triflate, tBu3SiO3SCF3, is easily obtained from tBu3SiH and CF3SO3H. Supersilyl triflate, tBu3SiO3SCF3, reacts with lithium amide or lithium hydrazide to form the supersilyl amine, tBu3SiNH2, or the supersilyl hydrazines, tBu3SiNHNH2 and tBu3SiNH-HNSitBu3, respectively. The structures of supersilyl triflate, tBu3SiO3SCF3, and bissupersilyl hydrazine, tBu3SiNH-HNSitBu3, have been determined by X-ray structure analysis.
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Shu, Zhang, Wang Longyu, Cao Pengzhang, Gu Xuefan, Zhang Huani, and Chen Gang. "Synthesis of New Hydrazone Compounds from Natural Grease and Investigation as Flow Improver for Crude Oil." Нефтехимия 63, no. 3 (June 15, 2023): 354–62. http://dx.doi.org/10.31857/s0028242123030061.

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n this work, salicylaldehyde hydrazone (SAH), different from the traditional polymers, was synthesized from natural oils (castor, SAСH, rapeseed, SARH and soybean, SASH), hydrazine hydrate and salicylaldehyde. Firstly, natural grease reacts with hydrazine hydrate to produce hydrazide, and then salicylaldehyde reacts with hydrazide to synthesis salicylaldehyde hydrazone. In this work, SAH were evaluated as viscosity-reducers and pour point depressors for crude oil. The results show that the SAH can significantly reduce the pour point and viscosity of crude oil, with the increase of crude oil fluidity, the viscosity reduction rate of сrude oil from Jinghe Oilfield (QHO) reaches to 80.1% (40°С), the pour point decreases by 12.1°С, the viscosity reduction rate of сrude oil from Xinjiang Oilfield (STO) reaches to 87.5% (15°С), and the pour point decreases by 6.2°С. Based on the efficiency of different SAH, structure-function relationship was discussed. The mechanism of SAH effecting on crude oil is that the long alkyl chain is conducive to inhibiting the growth of crystals when eutectic with wax nuclei in heavy oil, and plays the role of pour point and viscosity reduction.
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Dissertations / Theses on the topic "Hydrazine"

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Hsu, Ivann Hong, Joanna Emerson, Andrew Wong, and Phillip Zinsli. "2-HYDROXYETHYL HYDRAZINE AND HYDRAZINE HYDRATE PLANT DESIGN." Thesis, The University of Arizona, 2009. http://hdl.handle.net/10150/192492.

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Saalmann, Thomas. "Umwandlung cyclischer Hydrazine." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97226888X.

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Guevrekian, Soghomoniantz Marina. "Synthèse de nouvelles hydrazones dérivées d'hydrazines disubstituées en position 1 : étude de leurs propriétés antibactériennes, de leur cytotoxicité sur deux espèces d'algues et de leur toxicité sur les alevins de truites." Paris 7, 1985. http://www.theses.fr/1985PA07F059.

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Cette thèse est constituée de deux parties, chimique et biologique. Des hydrazines disubstituées en position 1, soit par deux groupes acyles, soit par un groupe acyle et un groupe alkyle ou aralkyle, ont été préparées par une méthode originale. Ces hydrazines ont ensuite été traitées par des diacétates de nitro-5 furfurylidène ou de nitro-5 thénylidène pour donner les hydrazones correspondantes. Par ailleurs, la dibenzyloxycarbonyl-1,1 hydrazine a été synthétisée et utilisée pour faire la réaction de REES et des dérivés nouveaux de lfamino-1 aziridine ont été obtenus. Les hydrazones ont été testées sur trois espèces de bactéries : certaines d'entre elles présentent une activité sur Staphylococcus aureus et sur Escherichia coli. La plupart des nouvelles hydrazones ont été ensuite testées pour déterminer leur cytotoxicité sur deux espèces d'algues (marine et d'eau douce). L'une d'elles est cytotoxique à 3 ppm. Enfin, en raison d'éventuelles applications de ces résultats dans l'industrie, une étude de leur toxicité a été réalisée sur les alevins de truites : le produit le plus intéressant n'est toxique pour les alevins de truites qu'à une concentration sept fois supérieure à celle de sa cytotoxicité sur les algues.
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Vogt, Kirkland W. "Nitridation reactions with hydrazine." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/10032.

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REIS, RONALD DA SILVA. "TREATEMENT WASTEWATER EFFLUENTS CONTAINING HYDRAZINE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2003. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5112@1.

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No Brasil está em larga expansão o uso de geração de eletricidade por termoeléctricas. Na geração de eletricidade por usinas térmicas são utilizados grandes quantidades de água e produtos químicos, que após utilização geram efluentes. A hidrazina é um produto químico usado para controle de corrosão em águas de caldeiras, sistemas de vapor e outros sistemas de usinas térmicas que após utilização acaba incorporada aos efluentes líquidos destas usinas. Com intuito de promover uma sistemática de controle de efluentes produzidos nas usinas, procurou-se, nesta dissertação, estudar efluentes contendo hidrazina com enfoque tecnológico. O processo abordado neste estudo consistiu no tratamento de efluentes contendo hidrazina, utilizando peróxido de hidrogênio com auxílio de catalisador de íons de cobre, para decomposição da hidrazina. Os ensaios foram feitos em laboratório, utilizando-se efluentes sintéticos com concentrações pré- determinadas de hidrazina que variaram entre 10 e 100 mg/L, com controle do pH que variou em 7 e 9,5, temperatura fixada em 220C, com adição de concentrações calculadas de peróxido de hidrogênio e catalisador de sulfato de cobre. Concluiu-se que o processo é viável para reduzir a concentração de hidrazina em efluentes a níveis inferiores aos limites da legislação (1 mg/L), utilizando-se quantidades estequiométricas de peróxido de hidrogênio em conjunto com sulfato de cobre em concentrações de 1 mg/L de Cu 2+ como catalisador, em efluentes com pH 9,5, a temperatura ambiente, em tempos inferiores a 30 minutos. Assim sendo, o trabalho mostrou-se adequado para satisfazer as condições de descarte de efluentes em águas brasileiras de acordo com a resolução CONAMA 20, carta P-031/01 cláusula 2 artigo V, de 9 de Fevereiro de 2001.
In Brazil, the use of energy produced by power plant generators is in expansion. Power plants use large quantities of water and chemical products that after use end up in effluents. Hydrazine is used in water systems for corrosion control, because of its excelents oxygen scavenging capacity. The present work was conducted to study the treatment of effluents containing hydrazine, under a technological approach, with the purpose of contributing to a systematic of effluents control in power stations. The process studied in this work was the decomposition of hydrazine with hydrogen peroxid in presence catalyst cooper íon. The experiments were made in laboratory scale, using synthetic effluents with initial concentration of hydrazine at the levels 10 and 100 mg/L, with initial pH values 7 and 9,5, temperature fixed at 220C, with addition of st oichiometric amounts of hydrogen peroxide, with and without addition of cooper ion catalyst. It was conclued that the process its viable for reduction of hydrazine concentration in effluents with pH 9,5, below to levels under legislation (1mg/L), using stoichiometric amounts of hydrogen peroxide together with 1 mg/L of cooper ion, in times less that 30 minutes and ambient temperature. Therefore this work showed that the process is adequate in satisfying the Brazilian legislation for discharge of effluents into water bodies according to regulation CONAMA 20, letter P-031/01 clause 2 article V, 09 February 2001.
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Thompsett, David. "Hydrazine and carbazate complexes of chromium and manganese : their role in the catalytic decomposition of hydrazine." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376340.

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Moody, K. N. "The vapour phase oxidation of hydrazine." Thesis, University of Leeds, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354436.

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Huttenhower, Hillary Anne. "Development of new chemistry for a dual use hydrazine thruster, switchable room temperature ionic liquids, a study of silane grafting to polyethylene and its model compounds, synthesis of the novel hydrazine replacement fuel molecules 1,1-dimethyl-2-[2-azidoethyl]hydrazine and 1,1-dimethyl-2-[2-azidoethyl]hydrazone." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/41055.

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This thesis focuses on the development of new compounds or new processes that are more environmentally friendly and economical than those currently in use. The decomposition of hydrazine, a well established liquid rocket fuel for both the aerospace and defense industries, to the product ammonia is studied. Control of this reaction will allow hydrazine to be used as a propellant for both chemical and electric propulsion. From this a dual stage thruster will be developed that will be more efficient than current systems decreasing the amount of propellant needed and allowing for either a larger mission payload or a longer duration of individual missions. Hydrazine, while beneficial and well established, is also highly toxic, so other work in this thesis focuses on the synthesis of the novel molecule 1,1-dimethyl-2-[2-azidoethyl]hydrazine or DMAEH and its hydrazone intermediate 1,1-dimethyl-2-[2-azidoethyl]hydrazone or De-DMAEH as less toxic hydrazine replacements. Novel "switchable" ionic liquids have been investigated in this research. These are solvents that can change from molecular liquids to ionic liquids and back, simply with the addition or removal of CO₂ from the system. They can be used for a variety of applications, including as solvents for a reaction and separation system. Due to the recyclable nature of these solvents, waste is decreased making their development and implementation both environmentally and economically beneficial. Finally, the grafting reaction of vinyl silanes onto a hydrocarbon backbone is investigated. Fundamental work is being performed to study the graft distribution, selectivity and mechanism by which this reaction occurs. A more thorough understanding of how this reaction proceeds will allow for the development of a more efficient industrial process.
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Lindgren, Kristjon, and Dana Seng. "The Effects of Cyp2e1 on Hepatic Gene Expression in 129/Sv-Cyp2e1^tm1Gonz/J and 129S1/SvImJ Mice Exposed to Hydrazine." The University of Arizona, 2007. http://hdl.handle.net/10150/624424.

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Class of 2007 Abstract
Objectives: To characterize the difference in hepatic gene expression between Cyp2e1 +/+ and Cyp2e1 -/- mice after exposure to hydrazine in order to elucidate the functional pathway(s) for hydrazine-induced steatosis. Methods: The project was designed by Dr. Charlene McQueen and consisted of the following aims: (1) to characterize the hepatic pathology induced by hydrazine in CYP2E1 +/+ and -/- mice, (2) to evaluate hepatic gene expression profiles following exposure to hydrazine, and (3) to determine the expression of CYP2E1 and CYP4A14. The animal exposure and data collection have been completed and aim #2 is awaiting data analysis. Aim #2 consisted of treating CYP2E1 +/+ and CYP2E1 -/- mice to saline and hydrazine at doses of 100 mg/kg. Livers were collected at six and 24 hours and the mRNA was isolated with an Absolutely RNA RT-PCR Miniprep Kit. The transcriptome was determined using the Affymetrix GeneChip Expression Analysis System using total mouse genome GeneChips. The GeneChips were scanned using an Agilent GeneArray Scanner and the image was quantitated and archived awaiting data analysis. The data was collected by the SWEHSC Microarray Facility on June 20, 2005 was analyzed. The data analysis was completed by both Kristjon Lindgren and Dana Seng with the help and training from Dr. George Watts. The six sets of data from aim #2 was analyzed using Agilent's GeneSpring 7.3.1 software to characterize the two-fold differences in mice (n = 2 per group) hepatic gene expression. Genes of interest were identified as containing the keywords cyp, fatty, glutathione, hepat, lipid, liver, oxid, perox, steroid, and phosphatidylinositol in the Gene Ontology Biological Process, Cellular Component, or Molecular Function descriptions. Lastly, pathway mining of/for genes of interest was performed using Bioresource for array of genes (BioRag) available at www.biorag.org and maintained by the AzCC/SWEHSC Bioinformatics Facility. Results: The amount of information extracted from this research project is too immense to be described or summarized on this form. For more information, please obtain a copy of this research project from the University of Arizona College of Pharmacy or from the project co-authors Kristjon Lindgren (kristjon.lindgren@gmail.com) or Dana Seng (dana.seng@gmail.com). Conclusions: The effects of Cyp2e1 on hepatic gene expression in 129/Sv-Cyp2e1tm1Gonz/J and 129S1/SvImJ mice exposed to hydrazine was analyzed. Data showing that Cyp2e1 was protective against HD-induced hepatotoxicity was consistent with the proposed hypothesis. Hepatic gene expression results show that Cyp2e1 -/- mice have decreased expression of microsomal ω-oxidation genes (Cyp4a10 and Cyp4a14) compared to Cyp2e1 +/+ at 6h (both increased at 24h) and peroxisomal β–oxidation genes (Ehhadh) at 6h like Cyp2e1 +/+ (but increased at 24h only in Cyp2e1 -/-). Conversely, an increased expression of mitochondrial β-oxidation genes (Cpt1a) in both genotypes at 6 and 24h and cholesterol synthesis genes (Fdft1, Hmgcr, Hmgcs1, Idi, Lss, Mvk, Nsdhl, Sc4mol, and Sqle) in Cyp2e1 -/- at 24h was observed. These results support mechanisms by which ω-oxidation or PPARγ is protective or peroxisomal β- oxidation is damaging. Additional studies are needed to further eludidate the mechanisms of HD-induced steatosis.
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Clavette, Christian. "Synthesis of Beta-Aminocarbonyl Compounds and Hydrazine Derivatives Using Amino- and Imino-Isocyanates." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32004.

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Over the past recent years, β-aminocarbonyls have been of great interest to medicinal chemists. As a practical method to obtain these moieties, alkene aminocarbonylation, accounting for the formation of a C-N and a C-C bond, has been the subject of limited research efforts (very specific intramolecular metal-catalyzed variants have been reported). Direct aminocarbonylation of alkenes constitutes a challenging and an important potential innovation in the synthesis of β-aminocarbonyls such as β-amino acids. The research efforts described in the present thesis have been primarily directed towards the development of concerted pathways for the amination of alkenes using hydrazine derivatives as bifunctional reagents. Building on our previous report on the reactivity of hydrazides, progress on the aminocarbonylation of alkenes along with the synthetic scope of this reactivity are herein provided. Therefore, the first part of the present thesis (Chapter 2) focuses primarily on the development of thermolytic conditions for the intramolecular aminocarbonylation of alkenes using amino-isocyanates. Alongside, development of imino-isocyanates have provided complementary synthetic tools for aminocarbonylation. The second part (Chapter 3) describes the work accomplished towards intermolecular aminocarbonylation of alkenes and the synthesis of complex azomethine imine products (Chapter 3). Finally, the last part of the discussion (Chapter 4) will be on the development of new hydrazide reagents for the intramolecular Cope-type hydroamination of alkenes. In doing so, description of the synthetic utility of amino-isocyanates as amphoteric reagents for cascade reactions and heterocyclic synthesis will be provided.
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Books on the topic "Hydrazine"

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International Program on Chemical Safety., ed. Hydrazine. Geneva: World Health Organization, 1987.

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Organization, World Health, and International Program on Chemical Safety, eds. Hydrazine. Geneva: World Health Organization, 1987.

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Schmidt, Eckart W. Hydrazine and its derivatives: Preparation, properties, applications. 2nd ed. New York: Wiley-Interscience, 2001.

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Kagaku Busshitsu Hyōka Kenkyū Kikō and Shin Enerugī Sangyō Gijutsu Sōgō Kaihatsu Kikō (Japan), eds. Hidorajin: Hydrazine. Tōkyō-to Shibuya-ku: Seihin Hyōka Gijutsu Kiban Kikō Kagaku Busshitsu Hyōka Kenkyū Kikō, 2007.

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Shigeo, Murata, and United States. National Aeronautics and Space Administration., eds. Detonation velocity of the hydrazinum nitrate-hydrazine water system. Washington, DC: National Aeronautics and Space Administration, 1988.

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Patil, K. C., and Tanu Mimani Rattan, eds. Inorganic Hydrazine Derivatives. Chichester, United Kingdom: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.

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United States. National Aeronautics and Space Administration., ed. The catalysis of hydrazine. Washington, DC: National Aeronautics and Space Administration, 1987.

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Suzuki, M. Decomposition of hydrazine by high frequency glow electrical discharges. Washington, DC: National Aeronautics and Space Administration, 1988.

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International Program on Chemical Safety., International Labour Organisation, United Nations Environment Programme, and World Health Organization, eds. Hydrazine health and safety guide. Geneva: World Health Organization, 1991.

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Canada, Canada Health. Hydrazine sulphate: An information package. Toronto: Health Canada, 1996.

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Book chapters on the topic "Hydrazine"

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Dilworth, J. R., and S. Morton. "To Form Hydrazine and Hydrazine and Hydrazido Complexes." In Inorganic Reactions and Methods, 17–18. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145227.ch13.

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Lane, J. D., C. J. Pickett, and D. R. Stanley. "From Hydrazine and Coordinated Hydrazines." In Inorganic Reactions and Methods, 116–17. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145227.ch86.

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Lane, J. D., C. J. Pickett, and D. R. Stanley. "Hydrazine and Substituted Hydrazine Complexes." In Inorganic Reactions and Methods, 100–102. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145227.ch74.

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Aruna, Singanahally T., and K. C. Patil. "Hydrazine Salts." In Inorganic Hydrazine Derivatives, 37–82. Chichester, United Kingdom: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch02.

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Audrieth, L. F., T. T. Nickles, G. Gibson, and R. E. Kirk. "Hydrazine Sulfate." In Inorganic Syntheses, 90–91. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132326.ch31.

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Audrieth, L. F., T. T. Nickles, G. Gibson, and R. E. Kirk. "Recovery of Hydrazine Residues as Hydrazine Dihydro Chloride or Hydrazine Sulfate." In Inorganic Syntheses, 92–94. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132326.ch32.

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Patil, K. C., and Tanu Mimani Rattan. "Metal Hydrazine Carboxylates." In Inorganic Hydrazine Derivatives, 133–70. Chichester, United Kingdom: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch04.

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Vogt, J. "813 H4N2 Hydrazine." In Asymmetric Top Molecules. Part 3, 439–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-14145-4_235.

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Rattan, Tanu Mimani, and K. C. Patil. "Hydrazine and Its Inorganic Derivatives." In Inorganic Hydrazine Derivatives, 1–36. Chichester, United Kingdom: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch01.

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Gajapathy, Dasaratharam, and Tanu Mimani Rattan. "Metal Hydrazines." In Inorganic Hydrazine Derivatives, 83–132. Chichester, United Kingdom: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118693599.ch03.

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Conference papers on the topic "Hydrazine"

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Guo, Hong, Pengdi Ren, Xiaoyu Zhang, Guangxiong Chen, and Yi Ye. "Fretting Wear Behavior of NC30Fe in Distilled Water and Hydrazine Solution." In 2013 21st International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icone21-15879.

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In this study, fretting wear behavior of NC30Fe tubes against 1Cr13 stainless steel cylinder in distilled water and hydrazine solution was investigated at room temperature. Wear scar was analyzed systematically by NanoMap500DLS dual-mode profilometer, SEM, EDX. The results showed that the fretting logs were running in slip regime. The hydrazine solution may lead to corrosion. The friction coefficient in aqueous medium was lowered obviously, but it in distilled water was lower than that in hydrazine solution due to the effect of hydrazine solution. The wear was lightened in aqueous medium significantly, but it was more severe in hydrazine solution than that in distilled water for the reason of hydrazine solution. The abrasive wear, friction oxidation and delamination were the main wear mechanisms of NC30Fe in ambient. However, in aqueous medium the abrasive wear and delamination were the main wear mechanisms of NC30Fe.
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Popusoi, Ana, Nicanor Barba, and Aurelian Gulea. "Synthesis of 1,3-Phenyl(Pyridyl)propenones with thiosemicarbazidic groups." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab03.

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The bibliographic study of chalcones of the type 1,3-aryl(heteryl)propen-2-one with thiosemicarbazidic 4- and 1,4-disubstituted and thisemicarbazonic groups respectively gives us the information that they have a wide spectrum of biological activity, but methods of their synthesis are less described in the literature, and they became our object of study. 4,5-Dihydro-1-H-(pyrazol-3-yl)phenylhydrazinecarbothioamides 3a and 3b were obtained according to the following scheme:Reagents and reaction conditions: i, ii) 2-Py, 25oC – 24h, 90-95oC – 3h, 77-82%; iii) DMF, CH3COOH, 70-80oC, 2-3h, 60-63%. Figure 1. Synthesis of chalcone derivatives 3a, 3b, 4a and 4b.Initially N,N-dimethylthioureas 1a and 1b with hydrazine hydrate from hydrazones in pyridine at room temperature, which without being isolated upon heating cyclize to pyrazole derivatives (Fig. 1.) as described in the literature, and in parallel, dimethylamine is substituted by the hydrazine group [1] with the formation of compounds 3a and 3b, with a yield of 77%. Compound 3a was also obtained by an alternative route from isothiocyanatophenylpropen-2one 2a and hydrazine hydrate at room temperature, then on heating in pyridine (Fig. 1.). It is possible to from the same intermediates, which turn in to the finished product 3a, the yield is 82%. Compounds 4a and 4b were obtained from products 3a and 3b by boiling in ethanol with 2-pyridinecarboxyaldehyde. The antiproliferative activity of N-(4-(5-(pyridine-2-yl)-4,5dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridine-2-ylmethylene)hydrazinecarbotioamide towards HL-60 leukemia cells were patented [2].
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Won, Hui-Jun, Jung-Soon Park, Chong-Hun Jung, Sang-Yoon Park, Wang-Kyu Choi, and Jei-Kwon Moon. "A Reductive Dissolution Study of Magnetite." In ASME 2013 15th International Conference on Environmental Remediation and Radioactive Waste Management. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icem2013-96101.

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Magnetite dissolution tests using a hydrazine base solution were performed at a temperature range of 90 to 150 °C. The dissolution rate of magnetite increased with [N2H4], time, and temperature. The optimum solution pH in the experimental range was 3. The addition of copper ion to the hydrazine base solution greatly increased the magnetite dissolution rate. This was explained by the complex formation between N2H4 and Cu ions, and the reducing power of the hydrazine-Cu complex to the ferric ions of magnetite. The reductive decontamination solution can be applied below 100 °C by the addition of copper ions. The chemical decontamination of a Type 304 stainless steel specimen using a hydrazine base reductive decontamination solution was also performed. The contact dose rate was greatly decreased by the repetitive application of NP and the hydrazine base solution.
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Chapman, K., G. Mihaylov, B. Nurney, and K. Kirollos. "70. Selective, Direct-Read Monitoring System for Parts-Per-Billion Levels of Hydrazine, Monomethyl Hydrazine (MMH), and 1,1-Dimethyl Hydrazine (UDMH)." In AIHce 2003. AIHA, 2003. http://dx.doi.org/10.3320/1.2757969.

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Pathak, Anisha, and Banshi Dhar Gupta. "Palladium nanoparticles decorated MWCNTs engraved in polypyrrole matrix for the sensitive detection of hydrazine based on FOSPR." In JSAP-OSA Joint Symposia. Washington, D.C.: Optica Publishing Group, 2017. http://dx.doi.org/10.1364/jsap.2017.6a_a410_7.

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Hydrazine, a well-known reactive base and a critical reducing agent is a colorless liquid used substantially in industrial as well as in military applications [1]. Despite its acknowledged and long established applications, it is considered as a human carcinogen on minute levels of exposure through inhalation, ingestion or eye/skin contact. Hence, trace level detection of hydrazine is necessary for health safety. Various methods like liquid chromatography, spectrometry, electrochemical and optical have been reported for hydrazine sensing. We report a fiber optic SPR probe based on plasmonic property of silver thin film and palladium decorated MWCNTs engraved in polypyrrole matrix as sensing layer. Polypyrrole is a well-known conducting polymer used extensively for detection of hydrazine by charge transfer reactions leading to change in both its electrical and optical properties [2]. It also helps in attachments of Palladium-MWCNTs composite on silver coated probe.
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WHITEHEAD, JOHN, DON SWINK, JR., GERALD BREWSTER, JEFFREY MAYBEE, and HANS TOEWS. "Pumped hydrazine miniaturized propulsion system." In 25th Joint Propulsion Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1989. http://dx.doi.org/10.2514/6.1989-2958.

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Garcia, Benjamin O., and David J. Chavez. "Shock compression of liquid hydrazine." In Proceedings of the conference of the American Physical Society topical group on shock compression of condensed matter. AIP, 1996. http://dx.doi.org/10.1063/1.50612.

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Masse, Robert K., Benjamin A. Glassy, Ronald A. Spores, Andrew T. Vuong, Zhenghao Zhu, and Timothee L. Pourpoint. "Hydrazine-Based Green Monopropellant Blends." In AIAA SCITECH 2024 Forum. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2024. http://dx.doi.org/10.2514/6.2024-1619.

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Domae, Masafumi, Hirotaka Kawamura, Daisuke Akutagawa, Kenji Hisamune, Yosuke Katsumura, and Yusa Muroya. "Corrosion Test of 304 Stainless Steel in Hydrazine and Methanol Solutions at 320°C Under Gamma-Irradiation and Gamma Radiolysis of Hydrazine and Methanol." In 18th International Conference on Nuclear Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/icone18-29281.

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It has been pointed out that dissolved hydrogen is one of the key factors of PWSCC (primary water stress corrosion cracking) in the primary systems of pressurized water reactors. The authors consider that application of alternative reductant for hydrogen may mitigate PWSCC. The corrosion tests of 304 stainless steels in 2 mmol dm−3 methanol solution and 2 mmol dm−3 hydrazine solution at 320 °C were carried out under γ-ray irradiation, and the corrosion environment was evaluated. Electrochemical corrosion potential (ECP) of the stainless steels was measured during the immersion tests. The ECP values were −605 mV and −643 mV vs. SHE in 2 mmol dm−3 hydrazine solution and 2 mmol dm−3 methanol solution at 320 °C, respectively. After the immersion tests, oxide films formed on the stainless steel specimens were analyzed with scanning probe microscope and X-ray diffraction. It is concluded that from the ECP measurement and comparison with previous results corrosion environment under following conditions is similar: (1) DH 1.5 ppm without irradiation, (2) methanol 2.9 ppm without irradiation, (3) hydrazine 2 mmol dm−3 under γ-ray irradiation and (4) methanol 2 mmol dm−3 under γ-ray irradiation. During the immersion tests, the test waters were sampled several times, and analyzed, in order to understand radiolysis of the methanol solution and the hydrazine solution at 320 °C. Hydrazine is decomposed predominantly through thermal decomposition, and an ammonia molecule is formed from a hydrazine molecule. Formaldehyde and ethylene glycol were detected in the methanol solution. But, carboxylates were not detected. The present results do not demonstrate oxidation of methanol to CO or CO2. It is pointed out that irradiation experiments of higher absorbed dose are necessary.
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GRAY, C., and R. WOOD. "Development of a 500N bipropellant apogee engine capable of using hydrazine and monomethyl hydrazine." In 25th Joint Propulsion Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1989. http://dx.doi.org/10.2514/6.1989-2735.

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Reports on the topic "Hydrazine"

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Garcia, B., and D. Chavez. Shock compression of liquid hydrazine. Office of Scientific and Technical Information (OSTI), January 1995. http://dx.doi.org/10.2172/105881.

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Karraker, D. G. The Oxidation of Hydrazine by Nitric Acid. Office of Scientific and Technical Information (OSTI), July 2001. http://dx.doi.org/10.2172/784248.

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Thiem, Terry L., Jason Brown, Johnathan Kiel, Eric Holwitt, and Gerald J. O'Brien. The Chemical and Biochemical Degradation of Hydrazine. Fort Belvoir, VA: Defense Technical Information Center, January 1997. http://dx.doi.org/10.21236/ada333221.

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Karraker, D. G. Cu(II) - Catalyzed Hydrazine Reduction of Ferrous Nitrate. Office of Scientific and Technical Information (OSTI), October 2001. http://dx.doi.org/10.2172/787806.

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HARDING LAWSON ASSOCIATES NOVATO CA. Hydrazine Blending and Storage Facility, Interim Response Action. Fort Belvoir, VA: Defense Technical Information Center, January 1991. http://dx.doi.org/10.21236/ada273439.

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Karraker, D. G. The Iron-Catalyzed Oxidation of Hydrazine by Nitric Acid. Office of Scientific and Technical Information (OSTI), July 2001. http://dx.doi.org/10.2172/783929.

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Zube, Dieter M., and Dan Fye. Low Bus Voltage Hydrazine Arcjet System for Geostationary Satellites. Fort Belvoir, VA: Defense Technical Information Center, July 1998. http://dx.doi.org/10.21236/ada408186.

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Bertrand, Guy. Ammonia and hydrazine. Transition-metal-catalyzed hydroamination and metal-free catalyzed functionalization. Office of Scientific and Technical Information (OSTI), June 2012. http://dx.doi.org/10.2172/1253630.

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HARDING LAWSON ASSOCIATES NOVATO CA. Hydrazine Blending and Storage Facility, Interim Response Action Implementation. Final Safety Plan. Fort Belvoir, VA: Defense Technical Information Center, August 1989. http://dx.doi.org/10.21236/ada271897.

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HARDING LAWSON ASSOCIATES NOVATO CA. Hydrazine Blending and Storage Facility, Interim Response Action Implementation, Final Task Plan. Fort Belvoir, VA: Defense Technical Information Center, August 1989. http://dx.doi.org/10.21236/ada272026.

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