Journal articles: 'HYBRID BTC'

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Seto, Kahori, Junichi Shoda, Tomohisa Horibe, Eiji Warabi, Masayuki Kohno, Toru Yanagawa, Hiroki Bukawa, Yasuni Nakanuma, and Koji Kawakami. "Targeting Interleukin-4 Receptor Alpha by Hybrid Peptide for Novel Biliary Tract Cancer Therapy." International Journal of Hepatology 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/584650.

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It is known that the interleukin-4 receptorα(IL-4Rα) is highly expressed on the surface of various human solid tumors. We previously designed novel IL-4Rα-lytic hybrid peptide composed of binding peptide to IL-4Rαand cell-lytic peptide and reported that the designed IL-4Rα-lytic hybrid peptide exhibited cytotoxic and antitumor activity bothin vitroandin vivoagainst the human pancreatic cancer cells expressing IL-4Rα. Here, we evaluated the antitumor activity of the IL-4Rα-lytic hybrid peptide as a novel molecular targeted therapy for human biliary tract cancer (BTC). The IL-4Rα-lytic hybrid peptide showed cytotoxic activity in six BTC cell lines with a concentration that killed 50% of all cells (IC50) as low as 5 μM. We also showed that IL-4Rα-lytic hybrid peptide in combination with gemcitabine exhibited synergistic cytotoxic activityin vitro. In addition, intravenous administration of IL-4Rα-lytic hybrid peptide significantly inhibited tumor growth in a xenograft model of human BTCin vivo. Taken together, these results indicated that the IL-4Rα-lytic hybrid peptide is a potent agent that might provide a novel therapy for patients with BTC.

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Zhang, Hai-Long, Xiao-Yuan Wu, Jian-Zhen Liao, Xiao-Fei Kuang, Wenbin Yang, and Can-Zhong Lu. "A novel trigonal propeller-shaped hybrid tri-neodymium-polyoxometalate exhibiting single-molecule magnet behavior." Dalton Transactions 47, no. 6 (2018): 1796–800. http://dx.doi.org/10.1039/c7dt04908k.

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A trigonal propeller-shaped hybrid polyoxometalate (POM) (NH₂Me₂)₃{[Nd(Mo₄O₁₃)(DMF)₄]₃(BTC)₂}·8DMF (1; BTC = 1,3,5-benzenetricarboxylate) has been synthesized and structurally characterized.

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Lee, Do Nam, Yeong Rim Kim, Sohyeon Yang, Ngoc Minh Tran, Bong Joo Park, Su Jung Lee, Youngmee Kim, Hyojong Yoo, Sung-Jin Kim, and Jae Ho Shin. "Controllable Nitric Oxide Storage and Release in Cu-BTC: Crystallographic Insights and Bioactivity." International Journal of Molecular Sciences 23, no. 16 (August 13, 2022): 9098. http://dx.doi.org/10.3390/ijms23169098.

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Crystalline metal–organic frameworks (MOFs) are extensively used in areas such as gas storage and small-molecule drug delivery. Although Cu-BTC (1, MOF-199, BTC: benzene-1,3,5-tricarboxylate) has versatile applications, its NO storage and release characteristics are not amenable to therapeutic usage. In this work, micro-sized Cu-BTC was prepared solvothermally and then processed by ball-milling to prepare nano-sized Cu-BTC (2). The NO storage and release properties of the micro- and nano-sized Cu-BTC MOFs were morphology dependent. Control of the hydration degree and morphology of the NO delivery vehicle improved the NO release characteristics significantly. In particular, the nano-sized NO-loaded Cu-BTC (NO⊂nano-Cu-BTC, 4) released NO at 1.81 µmol·mg−1 in 1.2 h in PBS, which meets the requirements for clinical usage. The solid-state structural formula of NO⊂Cu-BTC was successfully determined to be [CuC6H2O5]·(NO)0.167 through single-crystal X-ray diffraction, suggesting no structural changes in Cu-BTC upon the intercalation of 0.167 equivalents of NO within the pores of Cu-BTC after NO loading. The structure of Cu-BTC was also stably maintained after NO release. NO⊂Cu-BTC exhibited significant antibacterial activity against six bacterial strains, including Gram-negative and positive bacteria. NO⊂Cu-BTC could be utilized as a hybrid NO donor to explore the synergistic effects of the known antibacterial properties of Cu-BTC.

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Wu, Y., and D. C. Coll. "BTC-VQ-DCT hybrid coding of digital images." IEEE Transactions on Communications 39, no. 9 (1991): 1283–87. http://dx.doi.org/10.1109/26.99132.

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Travlou, Nikolina A., Kavindra Singh, Enrique Rodríguez-Castellón, and Teresa J. Bandosz. "Cu–BTC MOF–graphene-based hybrid materials as low concentration ammonia sensors." Journal of Materials Chemistry A 3, no. 21 (2015): 11417–29. http://dx.doi.org/10.1039/c5ta01738f.

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Bikiaris, Nikolaos, Nina Ainali, Evi Christodoulou, Margaritis Kostoglou, Thomas Kehagias, Emilia Papasouli, Emmanuel Koukaras, and Stavroula Nanaki. "Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework." Nanomaterials 10, no. 12 (December 11, 2020): 2490. http://dx.doi.org/10.3390/nano10122490.

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In the present work, the porous metal-organic framework (MOF) Basolite®F300 (Fe-BTC) was tested as a potential drug-releasing depot to enhance the solubility of the anticancer drug paclitaxel (PTX) and to prepare controlled release formulations after its encapsulation in amphiphilic methoxy poly(ethylene glycol)-poly(ε-caprolactone) (mPEG-PCL) nanoparticles. Investigation revealed that drug adsorption in Fe-BTC reached approximately 40%, a relatively high level, and also led to an overall drug amorphization as confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The dissolution rate of PTX-loaded MOF was substantially enhanced achieving a complete (100%) release within four days, while the neat drug only reached a 13% maximum rate (3–4 days). This PTX-Fe-BTC nanocomposite was further encapsulated into a mPEG-PCL matrix, a typical aliphatic amphiphilic copolyester synthesized in our lab, whose biocompatibility was validated by in vitro cytotoxicity tests toward human umbilical vein endothelial cells (HUVEC). Encapsulation was performed according to the solid-in-oil-in-water emulsion/solvent evaporation technique, resulting in nanoparticles of about 143 nm, slightly larger of those prepared without the pre-adsorption of PTX on Fe-BTC (138 nm, respectively). Transmission electron microscopy (TEM) imaging revealed that spherical nanoparticles with embedded PTX-loaded Fe-BTC nanoparticles were indeed fabricated, with sizes ranging from 80 to 150 nm. Regions of the composite Fe-BTC-PTX system in the infrared (IR) spectrum are identified as signatures of the drug-MOF interaction. The dissolution profiles of all nanoparticles showed an initial burst release, attributed to the drug amount located at the nanoparticles surface or close to it, followed by a steadily and controlled release. This is corroborated by computational analysis that reveals that PTX attaches effectively to Fe-BTC building blocks, but its relatively large size limits diffusion through crystalline regions of Fe-BTC. The dissolution behaviour can be described through a bimodal diffusivity model. The nanoparticles studied could serve as potential chemotherapeutic candidates for PTX delivery.

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Wong, Danny, Osama Abuzalat, Sherif Mostafa, Simon S. Park, and Seonghwan Kim. "Intense pulsed light-based synthesis of hybrid TiO2–SnO2/MWCNT doped Cu-BTC for room temperature ammonia sensing." Journal of Materials Chemistry C 8, no. 22 (2020): 7567–74. http://dx.doi.org/10.1039/d0tc00762e.

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Yang, Ke, Yu Yan, Wen Chen, Hongtao Kang, Yi Han, Wenquan Zhang, Yafeng Fan, and Zhenxing Li. "Nut-like MOF/hydroxylated graphene hybrid materials for adsorptive desulfurization of thiophene." RSC Advances 8, no. 42 (2018): 23671–78. http://dx.doi.org/10.1039/c8ra03834a.

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A series of novel metal–organic framework/hydroxylated graphene hybrid materials were successfully designed and synthesized with different ratios of Cu-BTC and hydroxylated graphene and their adsorption performances for thiophene from oils were evaluated.

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Tiwari, Ranjay K., and J. N. Behera. "Hybrid materials based on transition metal–BTC–benzimidazole: solvent assisted crystallographic and structural switching." CrystEngComm 20, no. 41 (2018): 6602–12. http://dx.doi.org/10.1039/c8ce01299g.

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Five transition metal–BTC–BIm based coordination polymers with hierarchical structures were synthesized under hydro/solvothermal condition. Crystal structure analysis of the compounds showed that 1 forms a 1D chain, 2 and 3 have 2D layers, while 4 and 5 have three-dimensional architectures.

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Ayub, Nosheen, and Uzaira Rafique. "Synthesis and characterization of aluminosilicates [Zn3 (BTC)2] hybrid composite materials." Epitoanyag - Journal of Silicate Based and Composite Materials 69, no. 3 (2017): 98–101. http://dx.doi.org/10.14382/epitoanyag-jsbcm.2017.17.

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Petruseva, Silvana, Valentina Zileska-Pancovska, and Diana Car-Pušić. "Implementation of Process-Based and Data-Driven Models for Early Prediction of Construction Time." Advances in Civil Engineering 2019 (January 23, 2019): 1–12. http://dx.doi.org/10.1155/2019/7405863.

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The need of respecting the construction time as one of the construction contract elements points out that early prediction of construction time is of crucial importance for the construction project participants’ business. Thus, having a model for early prediction of construction time is useful not only for the participants involved in the construction contracting process, but also for other participants in the construction project realization. Regarding that, this paper aims to present a hybrid method for predicting construction time in the early project phase, which is a combination of process-based and data-driven models. Five hybrid models have been developed, and the most accurate one was the BTC-GRNN model, which uses Bromilow’s time-cost (BTC) model as a process-based model and the general regression neural network (GRNN) as a data-driven model. For evaluating the quality of the models, the 10-fold cross-validation method has been used. The mean absolute percentage error (MAPE) of the BTC-GRNN is 3.34% and the coefficient of determination R2, which reflects the global fit of the model, is 93.17%. These results show a drastic improvement of the accuracy in comparison to the model when only data-driven model (GRNN) has been used, where MAPE was 31.8% and R2 was 75.64%. This model can be useful to the investors, the contractors, the project managers, and other project participants for construction time prediction in the early project phases, especially in the phases of bidding and contracting, when many factors, that can determine the construction project realization, are unknown.

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Jain, Apurva, Rachna T. Shroff, Mingxin Zuo, Jacqueline Weatherly, Funda Meric-Bernstam, Randi Isaacs, Siraj Mahamed Ali, Tanios S. Bekaii-Saab, and Milind M. Javle. "Tumor mutational burden (TMB) and co-existing actionable mutations in biliary tract cancers (BTC)." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 4086. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.4086.

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4086 Background: Mutations in DNA repair pathway were identified in 13% of Biliary Tract Cancers (BTC) [ Cancer2016;122:3838–3847]. High TMB tumors including melanoma, lung cancer and those with microsatellite instability (MSI-H) are associated with susceptibility to immune blockade using checkpoint inhibitors. TMB data in BTC is limited and its association with actionable somatic mutation (mut) profiles in BTC is unknown. Methods: Comprehensive genomic profiling (CGP) of 309 FFPE tissue blocks of BTC pts with a hybrid capture of all coding exons of 236 cancer-related genes and 47 introns of 19 genes rearranged in cancer was done using FoundationOne. Base substitutions, indels, gene fusion/rearrangements, TMB, and MSI status were assessed. TMB was calculated by counting mutations across a 1.25Mb region and classified into high (TMBH; ≥20 mut/Mb), intermediate (TMBI; 6 - 19mut/Mb) and low (TMBL; < 6mut/Mb). MSI high (MSIH) and Stable (MSS) status was assigned by a computational algorithm examining 114 intronic homopolymer loci. Patients with TMB ≥6 mut/Mb (N = 60) were included in the clinical correlative portion of this study. Results: Sixty patients with TMB ≥6 mut were identified out of 309 pts of which 9 (15%) were TMBH and 51 (85%) were TMBI. These included 3 (5%) MSIH and 18 (30 %) MSS. The median age was 59 years (range: 29-86), 35 (58%) were females, majority were intrahepatic cholangiocarcinoma (n = 31; 52%) and 28 (47%) presented with advanced disease at diagnosis. Twenty three (38%) pts had received radiation therapy, 28 (47%) surgery and 3 (5%) received immunotherapy. Most frequent co-existing mut seen was TP53 (N = 35; 58%). APC mut was seen in 7 (12%) pts. DNA repair pathway muts ( MSH6, BRCA1, BRCA2, ATM, MLH1, or MSH2 genes) were identified in 78% of TMBH versus 16% in TMBI cases (p < 0.0001). Frequency of PIK3CA mut differed significantly between TMBH and TMBI (44% vs 10%, p < 0.0001). Pts with TMBI had a significantly better median OS (110 weeks) as compared to TMBH (43 weeks) (p = 0.003). Conclusions: DNA repair pathway and PIK3CA mut maybe associated with TMBH in BTC. A better understanding of TMB and associated actionable mutations in BTC may be of value for the management of BTC patients with targeted agents and immunotherapy.

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Azizi Vahed, Tahereh, M. Reza Naimi-Jamal, and Leila Panahi. "(Fe)MIL-100-Met@alginate: a hybrid polymer–MOF for enhancement of metformin's bioavailability and pH-controlled release." New Journal of Chemistry 42, no. 13 (2018): 11137–46. http://dx.doi.org/10.1039/c8nj01946k.

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Metformin hydrochloride (Met) was combined with iron(iii) chloride and trimesic acid (1,3,5-benzene tricarboxylic acid, BTC) as an organic linker in a short and simple method, providing a MOF in which the drug is a part of the constituent.

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Li, Sa-Ying, and Zhi-Hong Liu. "Co5In(BTC)4[B2O4(OH)]2: the first MOF material constructed by borate polyanions and carboxylate mixed ligands." Dalton Transactions 45, no. 1 (2016): 66–69. http://dx.doi.org/10.1039/c5dt03535j.

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A novel heterometallic organic–inorganic hybrid MOF material, Co₅In(BTC)₄[B₂O₄(OH)]₂, has been synthesized under ionothermal conditions. Its structure is characterized as a 3D open framework constructed by the Co_2.5In_0.5[B₂O₄(OH)] cluster and the 1,3,5-benzenetricarboxylate ligand.

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Umemoto, Kumiko, Hiroyuki Yamamoto, Ritsuko Oikawa, Hiroyuki Takeda, Ayako Doi, Yoshiki Horie, Takashi Ogura, et al. "Genomic alterations for novel targeted therapies in pancreatobiliary cancers from real-world data." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 4124. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.4124.

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4124 Background: Cancers of the pancreas and biliary tract remain one of the unfavorable malignant tumors with few driver genomic alterations. Tumor-agnostic approaches are promising for cancers with poor prognosis, with some potentially actionable alterations, such as BRCA1/2 mutations, ERBB2 amplification, MSI-High, or tumor mutational burden (TMB)-High. However, co-existing alterations, clinical significance of other genomic alterations, or frequency of alterations by clinical and genomic background are unclear. Here we investigated the genomic profile in a large cohort of advanced pancreatobiliary cancers to help refine and discover new targets for improved cancer therapies. Methods: Comprehensive genomic profiling was performed at Foundation Medicine, on patients with RWD tested during the course of routine clinical care. Hybrid capture was carried out on up to 395 cancer-related genes and select introns from up to 31 genes frequently rearranged in cancer. 16,913 pancreatic cancer (PC) patients and 3,031 biliary tract cancer (BTC) patients were available for analyses and were stratified by age (≥40/ < 40), MSI status, TMB status (High ≥10/Low < 10 Muts/Mb), and select gene alterations. Using a chi-square test with Yate’s correction, frequencies of genetic alterations were analyzed according to clinical or genomic background. Results: KRAS (84.8%), TP53 (73.3%), CDKN2A (51.2%), CDKN2B (26.5%), and SMAD4 (23.2%) were frequently altered in PC patients, versus TP53 (60.6%), CDKN2A (33.5%), KRAS (27.1%), CDKN2B (20.6%) and SMAD4 (16.9%) in BTC patients. The frequency of MSI-High and TMB-High in BTC was 1.2% and 5.7%, respectively, while these were lower in PC (0.48% and 2.1%, respectively). In PC patients, the KRAS alteration rate was significantly lower in both MSI-High (57.3%, P< 0.001) and TMB-High populations (51.3%, P< 0.001). In BTC patients, the rate of ERBB2 amplification was 6.4% in TMB-High and 8.6% in TMB-Low population. Interestingly, CDK12 rearrangement was observed in BTC patients with ERBB2 amplified tumors but not in those without ERBB2 amplified tumors. In patients of pediatric/adolescents and young adults ( < 40 years old), the mutation rate of KRAS/ TP53/ CDKN2A/ SMAD4 was lower, and FGFR2 rearrangement (4%) was observed in PC patients; GATA6 amplification (11.1%) and rearrangement of BRAF (2.8%), FGFR2 (5.6%) were observed in BTC patients. Conclusions: A large real-world dataset showed differences in genomic landscape according to clinical or genomic background, and some potential targets for the development of novel drugs in advanced pancreatobiliary cancers. These findings may lead to the improvement of cancer therapies in PC and BTC patients with poor prognosis.

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Lin, Zheng-Zhong, Fei-Long Jiang, Lian Chen, Da-Qiang Yuan, You-Fu Zhou, and Mao-Chun Hong. "Two Novel Inorganic-Organic Hybrid Frameworks Based on InIII-BTC and InIII-BTEC." European Journal of Inorganic Chemistry 2005, no. 1 (January 2005): 77–81. http://dx.doi.org/10.1002/ejic.200400591.

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Drozd, Oleksandr, Yevhen Zaika, and T. Pyvovar. "Character of inheritance of economic markings in flax." Bast and Technical Crops, no. 6(11) (December 1, 2018): 53–59. http://dx.doi.org/10.48096/btc.2018.6(11).53-59.

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In the first and second generation of hybrids revealed different character of inheritance of basic qualitative and quantitative traits – dominance, heterosis, over-domination and intermediate inheritance, which allows to assume high efficiency of individual selections in the following generations, with the selection of transgressive forms. The actual ratio of distribution groups in F2 hybrids and the genetic control of these traits in parental forms by weight of 1000 seeds were determined. The source material and the perspective hybrid combinations in the breeding nursery were studied and the perspective numbers were distinguished according to the complex of features.

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Magar, Satyawati, and Bhavani Sridharan. "Lossless Hybrid Coding technique based on Quasi Fractal & Oscillation Concept Method for Medical Image Compression." International Journal of Computer Communication and Informatics 2, no. 1 (May 29, 2020): 38–48. http://dx.doi.org/10.34256/ijcci2015.

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The Image compression is the most important entity in various fields. Image compression plays vital role in many applications. Out of which biomedical is one of the challenging applications. In medical research, everyday there is fast development and advancement. Medical researchers are thinking about digital storage of data hence medical image compression has a crucial role in hospitals. Here Morphological filter & adaptive threshold are used for refinement and used Quasi Fractal & Oscillation concept for developing new hybrid algorithm. Oscillation concept is lossy image compression technique hence applied on Non-ROI. Quasi fractal is lossless image compression technique applied on ROI. The experimental results shows that better CR with acceptable PSNR has been achieved using hybrid technique based on Morphological band pass filter and Adaptive thresholding for ROI. Here, innovative hybrid technique gives the CR 24.61 which improves a lot than hybrid method using BTC-SPIHT is 5.65. Especially PSNR is also retained and bit improved i.e. 33.51. This hybrid technique gives better quality of an image.

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Ye, Ranfeng, Min Ni, Hao Chen, and Shengqing Li. "Synthesis of mesoporous nickel–titanium-trimesic acid inorganic–organic hybrid composite in ionic liquid microemulsions for adsorption of rhodamine B from aqueous solution." Materials Express 10, no. 2 (February 1, 2020): 251–57. http://dx.doi.org/10.1166/mex.2020.1639.

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For the first time, mesoporous nickel–titanium-trimesic acid (NTT) inorganic–organic hybrid composite was synthesized in water-in-[Bmim]PF6 ionic liquid microemulsions using the trimesic acid (BTC) as the linker. The synthesized NTT was characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) analysis, powder X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR) methods, etc. Then, the isotherm and kinetic of adsorption were studied. The experimental data were well fitted with isotherm models of Langmuir and Freundlich (IMLF) at 298 K and 308 K and better fitted with the isotherm model of Langmuir (IML) at 318 K with the adsorption capacity of 662.212 μmol/g (maximum). The adsorption of rhodamine B (RhB) on NTT can be described by pseudo-second-order (PSO) kinetic model. This proposed method for synthesis of mesoporous NTT inorganic–organic hybrid composite is facile, environment-friendly and operated at room temperature, which could be applied to synthesis of other mesoporous inorganic–organic hybrid composites.

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Shuherk, Carol C., Susan R. Glaser, and Peter A. Glaser. "BreakThrough Communication in a Hybrid World: Amplifying Interactive, Experiential Learning." International Journal of Advanced Corporate Learning (iJAC) 15, no. 2 (November 29, 2022): 65–71. http://dx.doi.org/10.3991/ijac.v15i2.34091.

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This case study document describes the research foundation and instructional design of BreakThrough Communication, an evidence-based hybrid learning enterprise that builds organizational capacity by boosting communication skill in individuals and teams. BTC’s tiered talent development program combines asynchronous, self-paced video instruction in foundational knowledge; live virtual workshops customized to engage learners in practicing new skills on organizational challenges they face; and change-sustaining follow-through to embed new skills through assessment, video reinforcers, and real-time practice sessions. A certificate program that prepares internal trainers to assume communication coach roles completes the process. The BTC learning system is grounded in the traditional pedagogy of the communication field, aligns with adult learning theory, and reflects recent neuroscience research on how the human brain most efficiently learns. Three distinct areas of communication skill comprise the program’s subject material: inter-personal conflict; teamwork; persuasive speaking. The communication models within each area have been validated in both experimental and field studies, shown to change behavior and affect outcomes.

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Yang, Jie, Jia Li, Dickon H. L. Ng, Ping Yang, Wenning Yang, and Yong Liu. "Micromotor-assisted highly efficient Fenton catalysis by a laccase/Fe-BTC-NiFe2O4 nanozyme hybrid with a 3D hierarchical structure." Environmental Science: Nano 7, no. 9 (2020): 2573–83. http://dx.doi.org/10.1039/c9en01443h.

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Hao, Na, Fuchen Liu, Enbo Wang, Rudan Huang, Yangguang Li, and Changwen Hu. "A novel two-dimensional organic–inorganic hybrid compound with a (4,6)-lattice-type network: {[Co(H2O)2][Co2(phen)2(btc)2]}n (btc=benzene-1,2,4-tricarboxylate)." Inorganic Chemistry Communications 6, no. 6 (June 2003): 728–32. http://dx.doi.org/10.1016/s1387-7003(03)00094-7.

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Permana, Antonius Dimas Chandra, Ling Ding, Ignacio Guillermo Gonzalez-Martinez, Martin Hantusch, Kornelius Nielsch, Daria Mikhailova, and Ahmad Omar. "Comparative Study of Onion-like Carbons Prepared from Different Synthesis Routes towards Li-Ion Capacitor Application." Batteries 8, no. 10 (October 6, 2022): 160. http://dx.doi.org/10.3390/batteries8100160.

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Li-ion capacitors (LIC) have emerged as a promising hybrid energy storage system in response to increasing energy demands. However, to achieve excellent LIC performance at high rates, along with cycling stability, an alternative anode to graphite is needed. Porous high-surface-area carbons, such as onion-like carbons (OLCs), have been recently found to hold high potential as high-rate-capable LIC anodes. However, a systematic understanding of their synthesis route and morphology is lacking. In this study, OLCs prepared from self-made metal organic frameworks (MOFs) Fe-BTC and Fe-MIL100 by a simple pyrolysis method were compared to OLCs obtained via high-temperature annealing of nanodiamonds. The LICs with OLCs produced from Fe-BTC achieved a maximum energy density of 243 Wh kg−1 and a power density of 20,149 W kg−1. Furthermore, excellent capacitance retention of 78% after 10,000 cycles was demonstrated. LICs with MOF-derived OLCs surpassed the energy and power density of LICs with nanodiamond-derived OLCs. We determined the impact of the MOF precursor structure and morphology on the resulting OLC properties, as well as on the electrochemical performance. Thus, MOF-derived OLCs offer significant potential toward high-performance anode material for LICs, enabling control over structure and morphology, as well as easy scalability for industrial implementation.

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Delpiano, Giulia Rossella, Davide Tocco, Luca Medda, Edmond Magner, and Andrea Salis. "Adsorption of Malachite Green and Alizarin Red S Dyes Using Fe-BTC Metal Organic Framework as Adsorbent." International Journal of Molecular Sciences 22, no. 2 (January 14, 2021): 788. http://dx.doi.org/10.3390/ijms22020788.

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Synthetic organic dyes are widely used in various industrial sectors but are also among the most harmful water pollutants. In the last decade, significant efforts have been made to develop improved materials for the removal of dyes from water, in particular, on nanostructured adsorbent materials. Metal organic frameworks (MOFs) are an attractive class of hybrid nanostructured materials with an extremely wide range of applications including adsorption. In the present work, an iron-based Fe-BTC MOF, prepared according to a rapid, aqueous-based procedure, was used as an adsorbent for the removal of alizarin red S (ARS) and malachite green (MG) dyes from water. The synthesized material was characterized in detail, while the adsorption of the dyes was monitored by UV-Vis spectroscopy. An optimal adsorption pH of 4, likely due to the establishment of favorable interactions between dyes and Fe-BTC, was found. At this pH and at a temperature of 298 K, adsorption equilibrium was reached in less than 30 min following a pseudo-second order kinetics, with k″ of 4.29 × 10−3 and 3.98 × 10−2 g∙mg−1 min−1 for ARS and MG, respectively. The adsorption isotherm followed the Langmuir model with maximal adsorption capacities of 80 mg∙g−1 (ARS) and 177 mg∙g−1 (MG), and KL of 9.30·103 L∙mg−1 (ARS) and 51.56·103 L∙mg−1 (MG).

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Samuel, Melvin S., K. Mohanraj, Narendhar Chandrasekar, Ramachandran Balaji, and Ethiraj Selvarajan. "Synthesis of recyclable GO/Cu3(BTC)2/Fe3O4 hybrid nanocomposites with enhanced photocatalytic degradation of aflatoxin B1." Chemosphere 291 (March 2022): 132684. http://dx.doi.org/10.1016/j.chemosphere.2021.132684.

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Zhang, Qiuju, Lujie Cao, Baihai Li, and Liang Chen. "Catalyzed activation of CO2 by a Lewis-base site in W–Cu–BTC hybrid metal organic frameworks." Chemical Science 3, no. 9 (2012): 2708. http://dx.doi.org/10.1039/c2sc20521a.

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Riou-Cavellec, M., C. Albinet, C. Livage, N. Guillou, M. Noguès, J. M. Grenèche, and G. Férey. "Ferromagnetism of the hybrid open framework K[M3(BTC)3]·5H2O (M=Fe, Co) or MIL-45." Solid State Sciences 4, no. 2 (February 2002): 267–70. http://dx.doi.org/10.1016/s1293-2558(01)01225-0.

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Seo, You-Kyong, Geeta Hundal, In Tae Jang, Young Kyu Hwang, Chul-Ho Jun, and Jong-San Chang. "Microwave synthesis of hybrid inorganic–organic materials including porous Cu3(BTC)2 from Cu(II)-trimesate mixture." Microporous and Mesoporous Materials 119, no. 1-3 (March 2009): 331–37. http://dx.doi.org/10.1016/j.micromeso.2008.10.035.

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Smalenskaite, Aurelija, Lina Pavasaryte, Thomas Yang, and Aivaras Kareiva. "Undoped and Eu3+ Doped Magnesium-Aluminium Layered Double Hydroxides: Peculiarities of Intercalation of Organic Anions and Investigation of Luminescence Properties." Materials 12, no. 5 (March 4, 2019): 736. http://dx.doi.org/10.3390/ma12050736.

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The Mg3/Al and Mg3/Al0.99Eu0.01 layered double hydroxides (LDHs) were fabricated using a sol-gel chemistry approach and intercalated with different anions through ion exchange procedure. The influence of the origin of organic anion (oxalate, laurate, malonate, succinate, tartrate, benzoate, 1,3,5-benzentricarboxylate (BTC), 4-methylbenzoate (MB), 4-dimethylaminobenzoate (DMB) and 4-biphenylacetonate (BPhAc)) on the evolution of the chemical composition of the inorganic-organic LDHs system has been investigated. The obtained results indicated that the type and arrangement of organic guests between layers of the LDHs influence Eu3+ luminescence in the synthesized different hybrid inorganic–organic matrixes. For the characterization of synthesis products X-ray diffraction (XRD) analysis, infrared (FTIR) spectroscopy, fluorescence spectroscopy (FLS), and scanning electron microscopy (SEM), were used.

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Lin, Jianzhen, Xu Yang, Yinghao Cao, Guangyu Li, Songhui Zhao, Junping Shi, Jie Pan, et al. "Genomics and translational precision oncology for 803 patients with biliary tract cancer." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 4589. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.4589.

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4589 Background: Both incidence and mortality of biliary tract cancer (BTC) are increasing, and BTCs are characterized by poor prognosis and limited antitumoral treatments. There is no well-received regimen as the non-first-line treatment in patients with advanced BTCs, leading to the urgency of umbrella-setting personalized therapies according to genomic alterations. Methods: We performed genomic sequencing in a total of 803 BTCs, including 160 patients with whole-exome sequencing and 643 patients with hybrid capture–based comprehensive genomic profiling. Our molecular tumor board developed precise targeted therapies for patients with actionable targets. Results: Overall, the median tumor mutation burden was 3.0 (IQR: 0.8-6.1) Mut/Mb, with 10.5% patients of hypermutated BTCs. The most frequently mutated genes included TP53 (51%), KRAS (23%), ARID1A (16%) and SMAD4 (11%). The most common genes with significantly amplified oncogenes were CCND1 (6.97%), MET (6.72%) and MDM2 (6.6%), while the frequently deleted tumor-suppressor genes are CDKN2A (5.73%) and CDKN2B (5.35%). The mutational map of BTCs highlighted pathways of receptor-tyrosine kinase (RTK)/RAS and p53 signaling were frequently altered. Somatic truncating mutations of mismatch repair genes were identified in 6.1% (49/803) of patients, and germline pathogenic mutations in DNA damage response genes occurred in 8% (64/803) of BTCs. In addition, we demonstrate the amplified chromosomal focal at 7q31.2 was an oncogenic factor and it independently predicts both disease-free survival and overall survival of BTC patients. When molecular screening was linked to targeted therapies, 25.4% (204/803) of patients could match biomarker-assigned drug treatment (BADT). The frequent actionable biomarkers included amplifications of ERBB2 and MET, FGFR2/3 fusions and IDH1 mutations. For 46 patients with refractory BTCs received BADT, the objective response rate was 26.1%, with a median progression-free survival (mPFS) of 5.0 (95%CI: 3.5-6.5) months, and 56.8% patients achieved a ≥1.3 ratio of PFS2/PFS1. 4 of 6 (67%) patients with high microsatellite instability (MSI-H) BTCs had a responsive status after immunotherapy of PD1 inhibitor, confirming that MSI-H status was a robust biomarker of anti-PD1 treatments. Conclusions: Our study established the largest cohort in Chinese BTC patients to investigate the tumor mutational profiling and its translational clinical applications. Clinical trial information: NCT02715089 .

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Dong, Yayu, Jian Zhang, Yulin Yang, Lele Qiu, Debin Xia, Kaifeng Lin, Jiaqi Wang, Xiao Fan, and Ruiqing Fan. "Self‐Assembly of Hybrid Oxidant POM@Cu‐BTC for Enhanced Efficiency and Long‐Term Stability of Perovskite Solar Cells." Angewandte Chemie International Edition 58, no. 49 (December 2, 2019): 17610–15. http://dx.doi.org/10.1002/anie.201909291.

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Dong, Yayu, Jian Zhang, Yulin Yang, Lele Qiu, Debin Xia, Kaifeng Lin, Jiaqi Wang, Xiao Fan, and Ruiqing Fan. "Self‐Assembly of Hybrid Oxidant POM@Cu‐BTC for Enhanced Efficiency and Long‐Term Stability of Perovskite Solar Cells." Angewandte Chemie 131, no. 49 (October 23, 2019): 17774–79. http://dx.doi.org/10.1002/ange.201909291.

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Asma R Tariq, Asma R. Tariq, Misbah Sultan Misbah Sultan, Tariq Mahmud Tariq Mahmud, Ghayoor Abbas Chotana Ghayoor Abbas Chotana, Muhammad Rizwan Dilshad Muhammad Rizwan Dilshad, Asim Laeeq Khan Asim Laeeq Khan, Muhammad Imran Muhammad Imran, and Saadia Rashid Tariq and Prof Dr Klaus M. ller Buschbaum Saadia Rashid Tariq and Prof Dr Klaus M ller Buschbaum. "Use of 1D [Pr(BTC)(H2O)6] MOF as a Filler for Fabrication of Matrimidand#174; based MMMs." Journal of the chemical society of pakistan 45, no. 3 (2023): 203. http://dx.doi.org/10.52568/001245/jcsp/45.03.2023.

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Selection of good filler-polymer pair results in improved gas separation performances. Present study deals with fabrication of Matrimid based hybrid or mixed matrix membranes (MMMs) by using three weight loadings (10, 20 and 30 wt. %) of 1D rod shaped nanoporous [Pr(BTC)(H2O)6] metal organic framework (MOF). The fourier transform infrared (FTIR) spectrophotometric analysis indicated the bonding of lanthanide metal ion with the linker and thus formation of the MOF, and further revealed that the structure of MOF remained intact after incorporation into the polymer matrix. Powder X-ray (PXRD) analysis revealed purity and crystallinity of the MOF while the PXRD results for the MMMs indicated that crystallinity of the MOF remained unaffected after fabrication of the MMMs. The Scanning electron microscopy (SEM) results gave an indication of the formation of the MOF in same morphology as it is previously reported. Additionally, nice distribution and well adherence of the additive particles throughout the polymer matrix was observed while the interfacial voids were visibly absent. The MOF and the MMMs were thermally stable and crystallinity of MOF particles remained intact after dispersion into polymer matrix. The Brunauer Emmett Teller (BET) surface area of the MOF was also obtained that indicated its permanent porosity. The prepared MMMs were flexible enough to handle for all analysis. These findings led to conclude that a proper polymer-filler pair was made that produced defect free MMMs. The prepared MMMs can be evaluated in future for their performance towards separation of different gases after modification of the pore of the filler

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Zhang, Wenming, Jintao Chen, Xiaorui Li, Jiaqing Zhang, Yanan Li, Yajun Zhao, Liye Cao, and Xiaoshi Jin. "Cuprum Metal-Organic-Framework and Polyacrylonitrile-Derived Cu-N-C Electrocatalyst for Application in Zinc-Air Batteries." Nano 15, no. 01 (January 2020): 2050012. http://dx.doi.org/10.1142/s1793292020500125.

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Cu-N-C electrocatalyst was successfully prepared with Cu-BTC and polyacrylonitrile as templates by electrospinning and in-situ growth method. The effect of various [Formula: see text]-doped content on the electrochemical performance of the catalyst were investigated and the Cu-N-C-0.25 exhibited the best OER/ORR catalytic activities. When it was applied to the cathode of the zinc-air batteries, the power density of Cu-N-C-0.25 was 209.1[Formula: see text]mW[Formula: see text]cm[Formula: see text], which exceeded that of the commercial Pt/C[Formula: see text]IrO2 hybrid catalyst (157[Formula: see text]mW[Formula: see text]cm[Formula: see text]). The excellent electrochemical performance may be attributed to large number of active sites and high specific surface area on Cu-N-C electrocatalyst. It will be a promising alternative to precious metal catalysts containing Pt, Ir or Ru and their oxides.

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Lestari, Witri Wahyu, Robiah Al Adawiyah, Moh Ali Khafidhin, Rika Wijiyanti, Nurul Widiastuti, and Desi Suci Handayani. "CO2 gas separation using mixed matrix membranes based on polyethersulfone/MIL-100(Al)." Open Chemistry 19, no. 1 (January 1, 2021): 307–21. http://dx.doi.org/10.1515/chem-2021-0033.

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Abstract The excessive use of natural gas and other fossil fuels by the industrial sector leads to the production of great quantities of gas pollutants, including CO2, SO2, and NO x . Consequently, these gases increase the temperature of the earth, producing global warming. Different strategies have been developed to help overcome this problem, including the utilization of separation membrane technology. Mixed matrix membranes (MMMs) are hybrid membranes that combine an organic polymer as a matrix and an inorganic compound as a filler. In this study, MMMs were prepared based on polyethersulfone (PES) and a type of metal–organic framework (MOF), Materials of Institute Lavoisier (MIL)-100(Al) [Al3O(H2O)2(OH)(BTC)2] (BTC: benzene 1,3,5-tricarboxylate) using a phase inversion method. The influence on the properties of the produced membranes by addition of 5, 10, 20, and 30% MIL-100(Al) (w/w) to the PES was also investigated. Fourier-transform infrared spectroscopy (FTIR) analysis indicated that no chemical interactions occurred between PES and MIL-100(Al). Scanning electron microscope (SEM) images showed agglomeration at PES/MIL-100(Al) 30% (w/w) and that the thickness of the dense layer increased up to 3.70 µm. After the addition of MIL-100(Al) of 30% (w/w), the permeability of the MMMs for CO2, O2, and N2 gases was enhanced by approximately 16, 26, and 14 times, respectively, as compared with a neat PES membrane. The addition of MIL-100(Al) to PES increased the thermal stability of the membranes, reaching 40°C as indicated by thermogravimetry analysis (TGA). An addition of 20% MIL-100(Al) (w/w) increased membrane selectivity for CO2/O2 from 2.67 to 4.49 (approximately 68.5%), and the addition of 10% MIL-100(Al) increased membrane selectivity for CO2/N2 from 1.01 to 2.12 (approximately 110.1%).

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Samuel, Melvin S., Swati Suman, Venkateshkannan, Ethiraj Selvarajan, Thangavel Mathimani, and Arivalagan Pugazhendhi. "Immobilization of Cu3(btc)2 on graphene oxide-chitosan hybrid composite for the adsorption and photocatalytic degradation of methylene blue." Journal of Photochemistry and Photobiology B: Biology 204 (March 2020): 111809. http://dx.doi.org/10.1016/j.jphotobiol.2020.111809.

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Abdel-Wahab, Reham, Siraj Mahamed Ali, Mitesh J. Borad, Rachna T. Shroff, Lawrence Kwong, Jean-Nicolas Vauthey, Eugene Jon Koay, et al. "Variations in DNA repair genomic alterations and tumor mutation burden in biliary tract cancer (BTC) subtypes." Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 263. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.263.

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263 Background: DNA repair genomic alterations (GAs) have been identified in 12% of Intrahepatic cholangiocarcinoma (IHCCA), 26% of extrahepatic CCA (EHCCA) and 8% of gallbladder cancer (GBC) patients (pts) ( Cancer 2016;122:3838–3847). Recently, the Cancer Genome Atlas (TCGA) has described more than 20 mutated DNA repair genes, many of which were not previously represented in prior reports. DNA repair GAs including MSI are associated with higher tumor mutational burden (TMB). Our study aim is to identify variations in the frequency of DNA repair GAs in IHCCA, EHCCA, and GBC. Methods: Hybrid capture-based next-generation sequencing of 422 fixed formalin paraffin embedded (FFPE) tissue blocks of BTC including; 270 IHCCA, 60 EHCCA, and 92 GBC was performed. We included 20 DNA repair genes and classified them as "direct" DNA repair genes ( ATM, ATR, BRCA1, BRCA2, FANCA, FANCD2, MLH1, MSH2, MSH6, PALB2, POLD1, POLE, PRKDC, RAD50, SLX4) and "caretaker" genes that induce genomic instability ( BAP1, CDK12, MLL3, TP53, BLM). We calculated TMB on 1.1 Mb of sequenced DNA in 205 tissue specimens [138 IHCCA, 23 EHCCA, and 44 GBC] and classified into three groups; high (TMB-H; ≥ 20 mut/Mb), intermediate (TMB-I; 6-19mut/Mb) and low (TMB-L; < 6mut/Mb). Results: A distinct pattern of DNA repair GAs in each tumor type was detected. (Table 1). DNA repair GAs were more commonly noted in both EHCCA and GB (63%) as compared with IHCAA (45.2%) (p= .002). Direct DNA repair GAs were highest within EHCCA (25%), while indirect DNA GAs were predominant in GBC (59.8%) (p= 0.04 and 0.001, respectively). The frequency of TMB-H and TMB-I differed significantly between BTC subtypes. Pts with EHCCA and GBC had significantly higher TMB-H and TMB-I versus IHCCA. Conclusions: The frequency of DNA repair GA’s is higher in EHCCA and GBC as compared with IHCCA. These results may have implications for clinical trials with DNA repair inhibitors and immune checkpoint blockers. [Table: see text]

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Huang, Xiaoqiao, Li Cai, Tingting Fan, Kexi Sun, Le Yao, Lijun Zhang, and Zhongbo Li. "Fabrication of Au-Nanoparticle-Decorated Cu Mesh/Cu(OH)2@HKUST-1 Nanorod Arrays and Their Applications in Surface-Enhanced Raman Scattering." Sustainability 14, no. 1 (December 27, 2021): 228. http://dx.doi.org/10.3390/su14010228.

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Here we report a simple fabrication method for large-scale hybrid surface-enhanced Raman scattering (SERS) active substrates composed of Au-nanoparticle-decorated three-dimensional (3D) Cu(OH)2@HKUST-1 (Cu3(btc)2, H3btc = 1,3,5-benzenetricarboxylic acid) nanorod arrays on a woven Cu mesh (Cu mesh/Cu(OH)2@HKUST-1@Au). Cu(OH)2 nanorods were first obtained from a simple in situ chemical engraving Cu mesh and then utilized as self-sacrificing templates to achieve HKUST-1 nanocube-assembled nanorods; finally, Au nanoparticles (Au NPs) were sputtered onto the Cu(OH)2@HKUST-1 nanorods. Due to the large surface area, the three-dimensional Cu mesh/Cu(OH)2@HKUST-1 nanorods could load high-density Au NPs and capture target detection molecules, which is beneficial to the formation of a strong electromagnetic field coupling between Au NPs, and provides abundant “hot spots” for a sensitive and uniform SERS effect. Using the Cu mesh/Cu(OH)2@HKUST-1@Au nanorod arrays as the SERS substrate, 10−9 M Rhodamine 6G and 10−8 M 4-aminothiophenolcan were identified. To verify their practical application, the fabricated arrays were employed as SERS substrates for the detection of thiram, and 10−8 M thiram could be recognized. The hybrid SERS substrates show potential applications in the field of environmental pollutant detection and this is of great significance to the sustainable development of the environment.

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Yang, Yizhen, Qingxiang Wang, Weiwei Qiu, Hongxu Guo, and Feng Gao. "Covalent Immobilization of Cu3(btc)2 at Chitosan–Electroreduced Graphene Oxide Hybrid Film and Its Application for Simultaneous Detection of Dihydroxybenzene Isomers." Journal of Physical Chemistry C 120, no. 18 (May 4, 2016): 9794–803. http://dx.doi.org/10.1021/acs.jpcc.6b01574.

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Magar, Satyawati, and Bhavani Sridharan. "Comparative analysis of various Image compression techniques for Quasi Fractal lossless compression." International Journal of Computer Communication and Informatics 2, no. 2 (October 30, 2020): 30–45. http://dx.doi.org/10.34256/ijcci2024.

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The most important Entity to be considered in Image Compression methods are Paek to signal noise ratio and Compression ratio. These two parameters are considered to judge the quality of any Image.and they a play vital role in any Image processing applications. Biomedical domain is one of the critical areas where more image datasets are involved for analysis and biomedical image compression is very, much essential. Basically, compression techniques are classified into lossless and lossy. As the name indicates, in the lossless technique the image is compressed without any loss of data. But in the lossy, some information may loss. Here both lossy & lossless techniques for an image compression are used. In this research different compression approaches of these two categories are discussed and brain images for compression techniques are highlighted. Both lossy and lossless techniques are implemented by studying it’s advantages and disadvantages. For this research two important quality parameters i.e. CR & PSNR are calculated. Here existing techniques DCT, DFT, DWT & Fractal are implemented and introduced new techniques i.e Oscillation Concept method, BTC-SPIHT & Hybrid technique using adaptive threshold & Quasi Fractal Algorithm.

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Ndlovu, Thabani, and Delson Chikobvu. "A Wavelet-Decomposed WD-ARMA-GARCH-EVT Model Approach to Comparing the Riskiness of the BitCoin and South African Rand Exchange Rates." Data 8, no. 7 (July 24, 2023): 122. http://dx.doi.org/10.3390/data8070122.

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In this paper, a hybrid of a Wavelet Decomposition–Generalised Auto-Regressive Conditional Heteroscedasticity–Extreme Value Theory (WD-ARMA-GARCH-EVT) model is applied to estimate the Value at Risk (VaR) of BitCoin (BTC/USD) and the South African Rand (ZAR/USD). The aim is to measure and compare the riskiness of the two currencies. New and improved estimation techniques for VaR have been suggested in the last decade in the aftermath of the global financial crisis of 2008. This paper aims to provide an improved alternative to the already existing statistical tools in estimating a currency VaR empirically. Maximal Overlap Discrete Wavelet Transform (MODWT) and two mother wavelet filters on the returns series are considered in this paper, viz., the Haar and Daubechies (d4). The findings show that BitCoin/USD is riskier than ZAR/USD since it has a higher VaR per unit invested in each currency. At the 99% significance level, BitCoin/USD has average values of VaR of 2.71% and 4.98% for the WD-ARMA-GARCH-GPD and WD-ARMA-GARCH-GEVD models, respectively; and this is slightly higher than the respective 2.69% and 3.59% for the ZAR/USD. The average BitCoin/USD returns of 0.001990 are higher than ZAR/USD returns of −0.000125. These findings are consistent with the mean-variance portfolio theory, which suggests a higher yield for riskier assets. Based on the p-values of the Kupiec likelihood ratio test, the hybrid model adequacy is largely accepted, as p-values are greater than 0.05, except for the WD-ARMA-GARCH-GEVD models at a 99% significance level for both currencies. The findings are helpful to financial risk practitioners and forex traders in formulating their diversification and hedging strategies and ascertaining the risk-adjusted capital requirement to be set aside as a cushion in the event of the occurrence of an actual loss.

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Murray, Kate, Andrea Rossi, Diego Carraro, and Andrea Visentin. "On Forecasting Cryptocurrency Prices: A Comparison of Machine Learning, Deep Learning, and Ensembles." Forecasting 5, no. 1 (January 29, 2023): 196–209. http://dx.doi.org/10.3390/forecast5010010.

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Traders and investors are interested in accurately predicting cryptocurrency prices to increase returns and minimize risk. However, due to their uncertainty, volatility, and dynamism, forecasting crypto prices is a challenging time series analysis task. Researchers have proposed predictors based on statistical, machine learning (ML), and deep learning (DL) approaches, but the literature is limited. Indeed, it is narrow because it focuses on predicting only the prices of the few most famous cryptos. In addition, it is scattered because it compares different models on different cryptos inconsistently, and it lacks generality because solutions are overly complex and hard to reproduce in practice. The main goal of this paper is to provide a comparison framework that overcomes these limitations. We use this framework to run extensive experiments where we compare the performances of widely used statistical, ML, and DL approaches in the literature for predicting the price of five popular cryptocurrencies, i.e., XRP, Bitcoin (BTC), Litecoin (LTC), Ethereum (ETH), and Monero (XMR). To the best of our knowledge, we are also the first to propose using the temporal fusion transformer (TFT) on this task. Moreover, we extend our investigation to hybrid models and ensembles to assess whether combining single models boosts prediction accuracy. Our evaluation shows that DL approaches are the best predictors, particularly the LSTM, and this is consistently true across all the cryptos examined. LSTM reaches an average RMSE of 0.0222 and MAE of 0.0173, respectively, 2.7% and 1.7% better than the second-best model. To ensure reproducibility and stimulate future research contribution, we share the dataset and the code of the experiments.

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Castañón, Guillermo, Dan Jeffers, Héctor Hidalgo, and Hugo Tosquy. "Prueba de mestizos de maíz en el estado de Veracruz, México." Agronomía Mesoamericana 9, no. 2 (May 30, 2016): 89. http://dx.doi.org/10.15517/am.v9i2.20114.

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Twenty-four lines at the S5 inbreeding level were crossed with two testers (CML 247 and CML 254) to produce test crosses. The resulting hybrids were evaluated in San Andrés Tuxtla, and Ignacio de la Llave, where major environmental differences are found in temperature, precipitation, and average height above sea level. Results showed that general combining ability (GCA) and specific combining ability (SCA) were significant. Three variables were significant sources of variation in the first case: bad ear cover (BEC), roUen ears (RE), and grain yield (GY); while for hybrid combinations (line x tester), only two variables were significant: BEC and GY. Significant ACE values separated the lines by varialbe evaluated, but the most interesting variable was GY. In general, the best test crosses were superior to their commercial controls. Hybrid 12 had the highest GY, ranking 1 (Tester 1), producing 8973 kg/ha; and hybrid 4 had the lowest GY, ranking 24 (Tester 1), yielding 5480 kg/ha. Hybrids combined with Tester 2 had a lower performance: the highest GY - ranking as 1 - was hybrid 3- which produced 7972 kg/ha; and hybrid 20 showed the lowest GY, producing 3553 kg/ha, occupying the lowest position in the ranking. It was also noted that the lines x tester with the best SCA for GY resulted in higher values in at least one of the other three variables evaluated.

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FLINTHAM, J. E., W. J. ANGUS, and M. D. GALE. "Heterosis, overdominance for grain yield, and alpha-amylase activity in F1 hybrids between near-isogenic Rht dwarf and tall wheats." Journal of Agricultural Science 129, no. 4 (December 1997): 371–78. http://dx.doi.org/10.1017/s0021859697004899.

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The Rht-B1b, Rht-D1b and Rht-B1c alleles for reduced height in wheat (the Norin 10 and Tom Thumb dwarfing genes previously known as Rht1, Rht2 and Rht3) were exploited in combinations to generate a near-continuous range of plant heights, from 53 cm to 123 cm, amongst near-isogenic homozygotes and F1 hybrids. Pleiotropic yield effects of Rht genes were measured in both homozygous (intravarietal) and heterozygous (intervarietal) genetic backgrounds. Heterosis due to overdominance of Rht genes was detected among intravarietal hybrids. The effects of heterozygosity at other genetic loci (mean dominance) were determined, independently of Rht effects, from comparisons between intravarietal and intervarietal F1 hybrids.Genotypes of intermediate plant heights gave maximum yields, in agreement with other trials of the homozygous lines, so that heterosis (hybrid exceeding best parent) for Rht yield effects was observed in crosses between tall and dwarf isogenic pairs. This heterosis combined additively with increased mean weight per grain in intervarietal crosses, generating the highest overall grain yields in hybrids with semi-dwarf stature in heterozygous genetic backgrounds. The Rht-B1c allele showed single-gene overdominance for grain yield, also the production of alpha-amylase in ripening grains of Maris Huntsman was effectively inhibited in the Rht-B1a/c intravarietal hybrid. The Rht-B1c allele thus offers advantages for both grain yield and grain quality in the heterozygous condition and should be considered as an alternative to the conventional semi-dwarfing genes Rht-B1b and Rht-D1b for F1 varieties in environments conductive to preharvest sprouting.

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Cabaniols, J. P., I. Bolonakis-Tsilivakos, R. Cibotti, E. Churaqui, H. T. Duc, O. Halle-Pannenko, and K. Kosmatopoulos. "Mechanism of hybrid resistance. The role of a natural antibody in parental bone marrow cell rejection." Journal of Immunology 146, no. 3 (February 1, 1991): 860–64. http://dx.doi.org/10.4049/jimmunol.146.3.860.

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Abstract Hybrid resistance (HR) to parental bone marrow growth is specifically directed against hemopoietic histocompatibility (Hh-1) Ag that are present in parental bone marrow cells (bmc). The mechanism of HR seems to be a multistep process. According to a model we proposed earlier, a T cell recognizes the Hh-1 Ag and stimulates a macrophage to secrete IFN-alpha/beta (recognition phase). IFN-alpha/beta activates a NK-like cell that specifically kills the parental bmc (effector phase). We have also described in a previous paper that serum from resistant F1 hybrids contains a humoral factor that seems to be involved in the effector phase of HR. In the present work, we study the role and the nature of this humoral factor. Our results show that this humoral factor: 1) is present in all resistant H-2Db heterozygous F1 hybrids we have tested but not in nonresistant H-2Db homozygous mice; 2) seems to recognize the Hh-1b Ag because it is absorbed on bmc from Hh-1b mice but not on bmc from Hh-1d and Hh-1- mice; and 3) is an IgG1 Ig (natural antibody). These results could help us to explain the specificity of HR at the effector phase by supposing that this natural antibody recognize the Hh-1 Ag and enable NK-like cells to kill parental bmc cells in Hh-1 specific manner.

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Schneider, David, and Jennifer McCullough. "The Basic Communication Course and College Student Retention: A Longitudinal Analysis." Journal of Communication Pedagogy 7 (2023): 148–64. http://dx.doi.org/10.31446/jcp.2023.1.10.

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This longitudinal study examined the relationship between two formats of the basic communication course (BCC) and first-year college student retention over a four-year period. Chi-square and logistic regression models indicated students who completed the BCC were more likely to be retained than those who did not complete the BCC. While completing the BCC was associated with retention for both formats, the hybrid BCC format was more consistently related to retention than the public speaking BCC. Students from certain demographic groups who completed the hybrid BCC were retained more frequently than students from the same demographic who did not complete the hybrid BCC. Demographics for the public speaking BCC revealed a different retention profile. Implications and future directions concerning the BCC are discussed.

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YALÇIN, Emre Deniz, and Aykut ÇANAKÇI. "CORROSION AND WEAR PERFORMANCE OF ZA27/GRAPHENE/B4C HYBRID NANOCOMPOSITES PRODUCED BY POWDER METALLURGY." Acta Metallurgica Slovaca 26, no. 3 (September 3, 2020): 126–31. http://dx.doi.org/10.36547/ams.26.3.538.

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In this research paper, dry sliding (unlubricated), corrosion and abrasive wear behavior of ZA27/ Graphene/ B4C hybrid nanocomposites were studied. The hybrid nanocomposite samples were fabricated by powder metallurgy technique. Tribological tests were performed by employing a ball-on-disc type in the unlubricated situation and different loads (1, 2, 5 and 10 N). The examination of the worn and corroded surfaces, the powder characterization was performed using scanning electron microscopy (SEM). The findings indicated that the increase in B4C nano-particle content can positively effect on the corrosion and wear behavior of the hybrid nanocomposites. The electrochemical polarization measurements showed that increasing of the nano B4C content causes high corrosion resistance in the hybrid nanocomposites. The corrosion tests showed that the corrosion rate value of the ZA27/Graphene/B4C hybrid nanocomposites decreased from 59.02 mpy to 16.77 mpy with increasing the nano B4C content from 0.25% to 2%.

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Veeranki, Krishna Chaitanya, Jalapathi Pochampally, Ravi Chander Maroju, Vishnu Thumma, and Lakshmi Satya Boddu. "1,2,3-Triazoles containing Thiazole-Piperazine Moieties: Synthesis, Biological Assessment and Molecular Docking." Asian Journal of Chemistry 35, no. 1 (December 27, 2022): 125–34. http://dx.doi.org/10.14233/ajchem.2023.26904.

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A novel series of thiazole-triazole-piperazine multi hybrids was designed for antimicrobial activity and the synthetic method for this series has been developed by copper catalyzed 1,3-dipolar cycloaddition of thiazole-based azide with Boc-piperidine based alkyne in the presence of CuSO4 and sodium ascorbate. Boc deprotection followed by alkylation of piperidine moiety in hybrid derivatives was also carried out. All the target compounds were confirmed using FTIR, 1H NMR, 13C NMR and LC-MS spectral techniques. These compounds were screened for the antimicrobial activity against bacteria and fungi. The antimicrobial activities are also comparable to standard drugs ampicillin and clotrimazole. All the molecules showed good to moderate activity and supported by molecular docking studies and ADME prediction.

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Lautre, Reema, Murlidhar J. Sadawarti, Rajesh Lekhi, R. K. Samadhiya, S. P. Singh, Roop Singh Dangi, Vinod Kumar, Dharminder Verma, and Payal Patidar. "Performance of Short-duration Potato (Solanum tuberosum L.) Hybrids and Varieties for Growth and Yield Attributing Characteristics in Chambal Region of Madhya Pradesh, India." International Journal of Environment and Climate Change 13, no. 9 (July 25, 2023): 2019–32. http://dx.doi.org/10.9734/ijecc/2023/v13i92433.

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A total of thirteen different potato hybrids and varieties grown at ICAR-Central Potato Research Institute-Research Station, Gwalior were evaluated for different growth, morphological, and yield attributes for earliness in Chambal region of Madhya Pradesh. The experiment was laid out in randomized block design in three replications. Statistically non-significant variation was recorded under emergence at 30 days and days to senescence (70% maturity) ranged from 89.33% to 95.11% and 89.7 days to 97.7 days, respectively. A statistically significant effect was recorded under different growth parameters viz., day to emergence (days), plant height (cm), number of branches per plant (Stem/plant), number of compound leaves /plant, and plant vigour after 60 days of planting (scale 1-5). Control Kufri Ganga (24.28 t/ha) recorded a significant maximum marketable tuber yield at 60 DAP with a net return of Rs 97224 per ha and a B:C ratio 1:2 followed by Kufri Khyati yielded 23.31t/ha with a net return of Rs 89521 per ha and B:C ratio 1:1.92, Kufri Pukhraj yielded 23.02 t/ha with a net return of Rs 87150 per ha and B:C ratio 1:1.9, hybrid and P-31/J/7-37 & P-36/J/8-91 yields 21.72 t/ha with a net return of Rs 76780 per ha and B:C ratio 1:1.79. At 75 DAP, Kufri Khyati (37.33t/ha) recorded the highest marketable tuber yield with a net return of Rs 192909 per ha and B:C ratio of 1: 2.82 followed by Kufri Ganga (36.33 t/ha) with a net return of Rs 184909 per ha and B:C ratio 1:2.75, Hybrid P-40/J/8-85 (35.65 t/ha) with net return of Rs 179427 per ha and B:C ratio 1:2.70 and P-27/J/-05 (35.35t/ha) with a net return of Rs 177057 per ha and B:C ratio 1: 2.67, were spotted as best for cultivation in the Chambal region of Madhya Pradesh.

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Kim, Sung-Min, and Hyun Mee Kim. "Forecast Sensitivity Observation Impact in the 4DVAR and Hybrid-4DVAR Data Assimilation Systems." Journal of Atmospheric and Oceanic Technology 36, no. 8 (August 2019): 1563–75. http://dx.doi.org/10.1175/jtech-d-18-0240.1.

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AbstractIn this study, the observation impacts on 24-h forecast error reduction (FER), based on the adjoint method in the four-dimensional variational (4DVAR) data assimilation (DA) and hybrid-4DVAR DA systems coupled with the Unified Model, were evaluated from 0000 UTC 5 August to 1800 UTC 26 August 2014. The nonlinear FER in hybrid-4DVAR was 12.2% greater than that in 4DVAR due to the use of flow-dependent background error covariance (BEC), which was a weighted combination of the static BEC and the ensemble BEC based on ensemble forecasts. In hybrid-4DVAR, the observation impacts (i.e., the approximated nonlinear FER) for most observation types increase compared to those in 4DVAR. The increased observation impact from using hybrid-4DVAR instead of 4DVAR changes depending on the analysis time and regions. To calculate the ensemble BEC in hybrid-4DVAR, analyses at 0600 and 1800 UTC (0000 and 1200 UTC) used 3-h (9-h) ensemble forecasts. Greater observation impact was obtained when 3-h ensemble forecasts were used for the ensemble BEC at 0600 and 1800 UTC, than with 9-h ensemble forecasts at 0000 and 1200 UTC. Different from other observations, the atmospheric motion vectors (AMVs) deduced from geostationary satellite are more frequently observed in the same area. When the ensemble forecasts with longer integration times were used for the ensemble BEC in hybrid-4DVAR, the observation impact of the AMVs decreased the most in East Asia. This implies that the observation impact of AMVs in East Asia shows the highest sensitivity to the integration time of the ensemble members used for deducing the flow-dependent BEC in hybrid-4DVAR.

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