Relevant bibliographies by topics / HVE

Academic literature on the topic 'HVE'

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Published: 10 March 2023

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Journal articles on the topic "HVE"

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Vilain, Lionel. "Certification HVE, contribution au débat." Pour 201, no. 3 (2009): 25. http://dx.doi.org/10.3917/pour.201.0025.

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Vilain, Lionel. "Certification HVE : contribution au débat." Pour 202, no. 4 (2009): 12. http://dx.doi.org/10.3917/pour.202.0012.

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Lu, Weitao, Qi Qi, Ying Ma, Luwen Chen, Xu Yan, Vladimir A. Rakov, Daohong Wang, and Yijun Zhang. "Two basic leader connection scenarios observed in negative lightning attachment process." High Voltage 1, no. 1 (April 2016): 11–17. http://dx.doi.org/10.1049/hve.2016.0002.

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Zeng, Rong, Chijie Zhuang, Xuan Zhou, She Chen, Zezhong Wang, Zhanqing Yu, and Jinliang He. "Survey of recent progress on lightning and lightning protection research." High Voltage 1, no. 1 (April 2016): 2–10. http://dx.doi.org/10.1049/hve.2016.0004.

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Chen, Kunjin, Caowei Huang, and Jinliang He. "Fault detection, classification and location for transmission lines and distribution systems: a review on the methods." High Voltage 1, no. 1 (April 2016): 25–33. http://dx.doi.org/10.1049/hve.2016.0005.

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Tanaka, Hiroki, Daiki Tanahashi, Yoshihiro Baba, Naoto Nagaoka, Naoki Okada, Hideto Ohki, and Masayasu Takeuchi. "Finite‐difference time‐domain simulation of partial discharges in a gas insulated switchgear." High Voltage 1, no. 1 (April 2016): 52–56. http://dx.doi.org/10.1049/hve.2016.0006.

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Tarasenko, Victor F., and Dmitry V. Rybka. "Methods for recording the time profile of single ultrashort pulses of electron beams and discharge currents in real‐time mode." High Voltage 1, no. 1 (April 2016): 43–51. http://dx.doi.org/10.1049/hve.2016.0007.

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Xiao, Meng, and Bo Xue Du. "Review of high thermal conductivity polymer dielectrics for electrical insulation." High Voltage 1, no. 1 (April 2016): 34–42. http://dx.doi.org/10.1049/hve.2016.0008.

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Sima, Wenxia, Potao Sun, Ming Yang, Jingyu Wu, and Jiefang Hua. "Impact of time parameters of lightning impulse on the breakdown characteristics of oil paper insulation." High Voltage 1, no. 1 (April 2016): 18–24. http://dx.doi.org/10.1049/hve.2016.0009.

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Levko, Dmitry, and Laxminarayan L. Raja. "Influence of field emission on microwave microdischarges." High Voltage 1, no. 1 (April 2016): 57–59. http://dx.doi.org/10.1049/hve.2016.0010.

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Dissertations / Theses on the topic "HVE"

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Gomez, Consarnau Rafael J. "A Simplified Methodology for Validating the Hyper-Viscoelastic (HVE) Dynamic Response." Thesis, California State University, Long Beach, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10837944.

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This thesis presents a mathematical modeling process for characterizing a hyperelastic material with viscous response under dynamic loading conditions. The model is designed with the advantage of performing only one compressive dynamic test in order to provide the requisite parameters to fully determine the hyper-viscoelastic response. This is achieved in both deformations and contact forces, using digital image correlation and force sensors. Experiments performed at strain rates ranging from 10–3–10 2 s–1 correlate with computational simulations at the same loading rates up to 80% compression. The validity of the fit and prediction is assessed using MATLAB along with ABAQUS finite element software.

The results provided by this novel methodology, i.e. the mathematical model using non-homogeneous deformations and the subsequent dynamic experimental techniques, proves that this approach is a more effective alternative to the current standards used to characterize the mechanical response of hyperelastic, viscoelastic, and hyper-viscoelastic materials.

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Wang, Molin 1975. "Globalization and higher vocational education (HVE) in China : a case study in Shanghai." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102767.

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In China, higher vocational education (HVE) is a specific educational form in terms of its the educational goals, management structure, and close relationship with the economy. During the past quarter century, China has experienced not only a substantial increase in economic progress, but also the influence of globalization on its political, socio-economic, and educational development. This thesis examines how HVE has changed since the emergence of a socialist market economy (SME) in 1992. It interprets the relationship between globalization and HVE in terms of actual changes that have occurred at the Vocational College of Shanghai Jiaotong University (VCSJTU).
The thesis is significant for three reasons. First, it generates useful insights into the process of HVE policy implementation in China since its economic transformation in the early 1990s, and interprets the relationship between globalization, SME, and HVE. The case study also generates insights which can contribute to understanding HVE policy on learning in relation to the context of the economic situation within China and the impact of globalization. Second, the thesis puts special emphasis on analyzing the culture and value changes in VCSJTU since its foundation and explores the deep roots between different values and their implications for people's understanding and appreciation of globalization in the school context. Third, the academic contributions of this case study include theoretical frames of reference on culture, education, and economic globalization. In particular, the study outlines and analyzes (with reflections) the experience gained during the internal economic transformations within China---an analysis which contributes to the international sociology of education, to an understanding of the values within education in relation to the impact of globalization.
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Garcia, José Antonio Dias. "Efeito antiinflamatorio da S-nitroso-N-acetilcisteina (SNAC) na hipertrofia ventricular esquerda (HVE) em camundongos hipercolesterolemicos knockout para o receptor de LDL (LDLr-/-)." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314562.

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Orientadores: Marta Helena Krieger, Regina Celia Spadari-Bratfisch
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-08T07:50:11Z (GMT). No. of bitstreams: 1 Garcia_JoseAntonioDias_D.pdf: 1987747 bytes, checksum: 1ec8d731703522ccf42a42dafd7b13a7 (MD5) Previous issue date: 2006
Resumo: Recentemente demonstrou-se que S-nitroso-N-acetilcisteína (SNAC) atenua o desenvolvimento da placa de aterosclerose na aorta em cerca de 55% de camundongos deficientes do receptor de lipoproteína de baixa densidade (LDLr-/-). O presente estudo teve como objetivo: i) verificar se a deleção do gene do receptor de LDL pode alterar o perfil hemodinâmico e a resposta inotrópica do coração a agentes adrenérgicos; ii) determinar a capacidade do SNAC na prevenção das alterações estruturais e funcionais do miocárdio e; iii) verificar o efeito do SNAC na pressão arterial de camundongos hipercolesterolêmicos. Camundongos machos C57BL6 (Wild Type = WT) e camundongos LDLr-/- (S) foram alimentados com dieta comercial por 15 dias. Em relação aos camundongos WT, os camundongos S apresentaram aumento de 11% na pressão arterial, diminuição de 62% na contratilidade do átrio esquerdo, e aumento na expressão do CD40L e redução na expressão de NOSe no tecido ventricular esquerdo. Camundongos LDLr-/- alimentados com dieta enriquecida em 1,25% de colesterol, 20% de gordura e 0,5% de ácido cólico por 15dias (Chol) apresentaram hipertrofia ventricular esquerda (HVE) comparados aos camundongos S, a qual foi caracterizada por: a) aumento de 1,25 vezes na razão entre o peso ventricular esquerdo (mg) e o peso corporal (g) (4,17±0,09 vs 3,34±0,07 mg/g, respectivamente; p< 0,05); b) aumento do diâmetro dos cardiomiócitos (25±0,6 vs 19±0,7 µm, p<0.05); c) aumento na expressão das isoformas das NOS (óxido nítrico sintases) e hiperexpressão do CD40L; d) aumento do depósito de colágeno; e) sem alterações na performance contrátil do átrio esquerdo e na responsividade à noradrenalina. A administração do SNAC aos camundongos Chol (chol+SNAC) (0,51 µmol/kg/dia, i.p.), preveniu o aumento na razão do peso ventricular esquerdo (mg) e o peso corporal (g) (3.38±0.23 mg/g), no diâmetro dos cardiomiócitos (20±0.7 µm), no deposito de colágeno, na expressão das isoformas da NOS e a hiperexpressão do CD40L. O SNAC não apresentou efeito no aumento da pressão arterial e nem sobre a hipocontratilidade, mas recuperou a responsividade para noradrenalina. Em conclusão, o presente estudo demonstrou que camundongos com deleção do gene do receptor LDL apresentaram hipertensão e marcada redução contrátil. Essas características podem estar relacionados com o estresse oxidativo resultante do processo inflamatório e da hipoexpressão da NOSe. A dieta hiperlipídica promoveu hipertrofia ventricular esquerda (HVE), devida ao aumento nos processos inflamatório e oxidativo. O SNAC impediu o desenvolvimento da HVE por mecanismos que envolveram efeito antiinflamatório (detectado pela diminuição na expressão do CD40L), a hiperexpressão das NOS, a redução das alterações estruturais ventriculares induzidas pela hipercolesterolemia de maneira independente da hipertensão. No presente estudo, a necessidade de quantificar as análises histológicas exigiu a validação de um software interativo para analisar imagens de amostras teciduais. O software foi projetado para permitir que o usuário altere os tipos de coloração vermelha, verde e azul (RGB) para uma cor padrão que possa ser usada para segmentar a imagem e calcular a fração da área de interesse. Os resultados obtidos com a contagem manual e com a contagem feita com o uso do software foram similares, indicando que são métodos alternativos confiáveis para análises quantitativas de cortes histológicos. Entretanto, o software permite processar as imagens de maneira eficiente e confiável, além de reproduzir o corte tecidual em um menor tempo, e pode ser executado com o microscópio e o computador padrão
Abstract: Recently, it has been that S-nitroso-N-acetylcysteine (SNAC) attenuate in 55% the plaque development in low-density lipoprotein-receptor-deficient (LDLr-/-) mice fed a hypercholesterolemic diet for 15 days. The present study was designed to verify whether deletion of the low-density lipoprotein (LDL) receptor gene may affect the hemodynamic profile and adrenergic inotropic cardiac responses and, particularly, to identify the ability of SNAC to prevent the myocardial alterations and hypertension in hypercholesterolemic mice. C57BL6 wild-type (WT) and LDLr-/- male mice (S) were fed a commercial diet for 15 days. Control mice (S) showed 11 % blood pressure increase, 62% left atrial contractility decrease, CD40L overexpression and eNOS underexpression in comparison to WT. LDLr-/- mice which were fed for 15 days with 1,25% cholesterol, 20% of fat and 0.5% of colic acid enriched diet (Chol), showed significant left ventricular hypertrophy (LVH) versus S, which was characterized by: a) 1.25-fold increase in the LV weight (mg)/body weight (g) ratio (4.17±0.09 vs. 3.34±0.07 mg/g, respectively; p<0.05); b) increased cardiomyocyte diameter (25±0.6 vs. 19±0.7 µm, p<0.05); c) enhanced expression of the constitutive and inducible NOS isoforms and CD40L;d) increased collagen deposit; e) no alteration in the atrial contractile performance or responsiveness to norepinephrine. Administration of SNAC to Chol mice ( Chol +SNAC) (0.51 µmol/kg/day, for 15day, i.p.) prevented increases in the left ventricular weight/body weight ratio (3.38±0.23 mg/g), cardiomyocyte diameter (20±0.7 µm), collagen deposit, NOS isoforms and CD40L overexpression, but had no effect on increased blood pressure or atrial basal hypocontractility, although it recovered responsiveness to norepinephrine. In conclusion, the present study demonstrated that the deletion of the LDL receptor gene in mice determined hypertension and a marked left atrial contractile deficit. These findings may be related to oxidative stress, resulting from inflammation and eNOS underexpression. High-cholesterol diet promoted LVH in LDLr-/- mice associated with enhanced inflammatory and oxidant processes. SNAC prevented LVH by processes that involved decreased CD40L expression and NOS overexpression effects attenuating the ventricular structural alterations induced by hypercholesterolemia independent of hypertension. Histological quantization demanded the development of interactive software for image analysis of tissue samples. The software was designed to allow a user-oriented change of a chosen red, green and blue (RGB) staining in a standardized color that can be used to segment the image and calculate the fractional area of interest. Thus the method allows efficient, reliable and reproducible processing of tissue sections that is less time-consuming than conventional methods and can be performed with standard microscope and computer
Doutorado
Fisiologia
Doutor em Biologia Funcional e Molecular
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Bispo, Vanderson da Silva. "Investigação dos mecanismos biológicos de detoxificação de aldeídos α,β- insaturados em ratos SODG93A modelo para ALS." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-07122015-105825/.

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A lipoperoxidação gera diversas espécies carbonílicas altamente reativas dentre as quais se destacam acroleína (ACR), malondialdeído (MDA), 4-hidroxi-2-hexenal (HHE) e 4-hidroxi-2-nonenal (HNE). A principal via endógena de metabolização desses compostos é através de conjugação com glutationa por ação da glutationa-S-tranferase. Contudo, diversos trabalhos têm mostrado que dipeptídeos contendo histidina, tal como a carnosina (CAR), também podem formar conjugados com aldeídos e auxiliar na detoxificação desses compostos. Em nosso trabalho adutos de CAR com ACR, HHE, HHEd5, HNE e HNEd11 foram sintetizados, purificados e caracterizados. A reação da CAR com ACR foi estudada em detalhes. Resultados mostraram que a carnosina reage com acroleína formando 03 produtos principais: m/z = 265, m/z = 283 e m/z = 303, sendo este último mais estável e mais abundante. Dados de RMN H1, COSY e HSQC permitiram elucidar a estrutura dessa molécula (m/z = 303) e propor uma rota de reação. Em seguida, uma metodologia baseada em cromatografia líquida acoplada à espectrometria de massas do tipo \"Ion Trap\" (ESI+ HPLC/MS-MS) foi desenvolvida e validada para quantificação simultânea dos adutos sintetizados. Pelo método desenvolvido é possível quantificar com precisão 25 pmol de CAR-HHE, 1 pmol de CAR-ACR e 1 pmol de CAR-HNE com um coeficiente de variação de aproximadamente 10 % e acurácia de 98 % (HHEd5 e HNEd11 foram usados como padrão interno). Análise em urina de adultos não fumantes mostraram que os produtos sintetizados estão presentes na urina de humanos em concentrações de 3,6 ± 1,4; 2,3 ± 1,5 e 1,3 ± 0,5 nmol / mg de creatinina, respectivamente para CAR-ACR, CAR-HHE e CAR-HNE. Em ratos transgênicos SODG93A modelo para esclerose lateral amiotrófica (ELA), a suplementação da dieta dos animais com 35 ± 5 mg carnosina/animal/semana melhorou a manutenção do peso e a sobrevida dos animais. Análises dos adutos sintetizados em amostras de músculo sugerem que a metabolização de aldeídos esteja comprometida nesses animais e que a carnosina poderia funcionar como \"scavenger\" para esses compostos. Esses resultados comprovam que dipeptídeos de histidina atuam na detoxificação de compostos carbonílicos e participa de suas vias de excreção. Além disso, a caracterização da estrutura e desenvolvimento de método sensível de detecção abre a possibilidade de utilização desses adutos como biomarcadores de estresse redox e exposição a aldeídos.
Lipid peroxidation generates reactive carbonyl species, including 4-hydroxy-2-nonenal (HNE), acrolein (ACR), 4-hydroxy-2-hexenal (HHE) and malondialdehyde (MDA). One major pathway of aldehyde detoxification in vivo is through conjugation with glutathione catalyzed by glutathione-S-transferases or, alternatively, by conjugation with endogenous histidine containing dipeptides, such as carnosine (CAR). The reaction of CAR with ACR was investigated in an effort to assess its possible biological role. One stable adduct was isolated by reverse-phase HPLC and characterized on the basis of extensive spectroscopic measurements. The proposed reaction route for product formation involves the reaction of the CAR amino group with ACR via a Schiff base formation followed by dehydration and cyclization through Michael addition in the imidazole ring forming an instable compound with m/z = 265. The subsequent reaction with another molecule of ACR followed by cyclization gives rise to the final product with m/z = 303.A highly sensitive method involving HPLC-MS analysis was developed for the simultaneous accurate quantification of CAR- ACR, CAR-HHE and CAR-HNE adducts in human urinary samples from non-smoking adults. This methodology permits quantification of 10 pmol CAR-HHE and 1 pmol of CAR-ACR and CAR-HNE. Adduct levels in urine were 3.6 ± 1.4, 2.3 ± 1.5, 1.3 ± 0.5 nmol/mg of creatinine, respectively to CAR-ACR, CAR-HHE and CAR-HNE. In SODG93A transgenic rats model to amyotrophic lateral sclerosis (ALS), the food supplementation of the animals with 35 ± 5 mg carnosine/animal/week improve de body weight and the life span of the ALS treated group. Analysis of the synthesized adducts in muscle sample showed suggest than aldehyde metabolization is compromised in this animals and that may be carnosine work like a scavenger for these compounds. Our results indicate that carnosine adduction can be an important detoxification route of α,β -unsaturated aldehydes. Moreover, carnosine adducts quantification may be useful as redox stress indicator in vivo.
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Pudupakam, Raghavendra Sumanth Kumar. "Understanding the Role of the Hypervariable Region in the Open Reading Frame 1 of the Hepatitis E virus in Viral Replication." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/77083.

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Hepatitis E virus (HEV) is a major cause of enterically transmitted acute viral hepatitis in developing countries that lack proper hygienic infrastructure. Hepatitis E is globally distributed and has emerged as an important public health disease in both developing and industrialized countries. HEV is a non-enveloped virus carrying a single-stranded positive-sense RNA genome of approximately 7.200 bp in length. The life cycle of HEV is poorly understood due to the lack of an efficient cell culture system. Animal model systems, including non-human primates, swine, and chickens are being used to study some fundamental aspects of the HEV biology. Recently, novel animal strains of rat and rabbit HEV have been discovered, and whose usage as animal model systems needs to be established. HEV infections in pigs and chickens provide excellent model systems to study the replication and pathogenesis aspects of HEV. Recently, we identified a hypervariable region (HVR) in the open reading frame 1 (ORF1) of HEV. The objectives of this dissertation were to utilize chicken and swine model systems to study the role of HVR in HEV infection in vivo, to determine the effects of HVR on replication of HEV in vitro, and to analyze the effect of exchange of HVR among different genotypes on the replication-competency and virion production in vitro. Extensive sequence variability in the HVR among HEV strains of different genotypes prompted us to study the dispensability of this region. Initially we constructed two partial deletion mutants of genotype 1 human HEV, hHVRd1 and hHVRd2, with in-frame deletion of amino acids (aa) 711 to 777 and 747 to 761 in the HVR of a sub-genomic GFP HEV replicon. Expression of enhanced green fluorescent protein by the mutant hHVRd2 confirmed the dispensability of amino acid residues 747-761 of the HVR. To confirm our in vitro results, specific-pathogen-free (SPF) chickens were intra-hepatically inoculated with capped RNA transcripts from three avian HEV HVR-deletion mutants: mutants aHVRd1 (Δ557-585), aHVRd2 (Δ612-641), and aHVRd3 (Δ557-641). Chickens intra-hepatically inoculated with the mutants, aHVRd1 and aHVRd2, developed active viral infection as evidenced by seroconversion, viremia, and fecal virus shedding. Mutant aHVRd3, with a larger HVR deletion, was apparently attenuated in chickens. Additionally, we used the swine model system to further verify our results from the chicken study. The infectivity of four genotype 3 swine HEV HVR-deletion mutants, sHVRd1 (Δ712-790), sHVRd2 (Δ722-781), sHVRd3 (Δ735-765), and sHVRd4 (Δ712-765) constructed using the genotype 3 swine HEV as the backbone was determined in SPF pigs. Pigs intra-hepatically inoculated with capped RNA transcripts from the mutants sHVRd2, sHVRd3, and sHVRd4 developed active viral infection, whereas mutant sHVRd1 (Δ712-790), with a nearly complete HVR deletion, exhibited an attenuation phenotype. The data from these studies indicate that deletions in HVR do not abolish HEV infectivity in vitro or in vivo, although evidence for attenuation was observed for HEV mutants with a larger or nearly complete HVR deletion. To further elucidate the role of HVR in HEV replication, we investigated the effects of serial amino acid deletions in HVR on the replication of HEV. We first constructed a genotype 1 human HEV luciferase replicon by replacing the ORF2 gene that encodes for the capsid protein with the fire fly luciferase reporter gene. Using the backbone of human HEV genotype 1 luciferase replicon, we constructed a series of HVR-deletion mutants with deletions of variable lengths in the HVR. Amino acid deletions Δ711-725, 711-740 and Δ711-750 were engineered at the N-terminus, deletions Δ729-754, Δ721-766, and Δ716-771 were engineered in the central region, and deletions Δ761-775, Δ746-775, and Δ736-775 were engineered at C-terminus of the HVR. The effects of these serial deletions on HEV RNA replication in the human liver carcinoma cell line, Huh7, were examined. Replication levels of mutants carrying these deletions were compared with that of the wild-type HEV in Huh7 cells. We observed that deletions in the HVR did not abolish viral RNA synthesis but substantially reduced the replication levels of viral RNA, as measured by the reporter luciferase activity. To further verify the effects of HVR deletions on viral RNA replication as observed with the genotype 1 human HEV replicon, we subsequently used a genetically-distinct strain of HEV, avian HEV, and constructed an avian HEV sub-genomic luciferase replicon by substituting the ORF2 gene of avian HEV with the fire fly luciferase gene. Avian HEV HVR-deletion mutants Δ557-603, Δ566-595, and Δ573-587 were then engineered using the backbone of avian HEV luciferase replicon. The replication efficiency of the three deletion mutants of avian HEV in chicken liver hepatoma cell line, LMH, was evaluated. Compared with the wild-type avian HEV, the viral RNA synthesis of the avian HEV HVR-deletion mutants was considerably reduced by the HVR deletions. To analyze the impact of the complete HVR deletion on avian HEV infectivity, we constructed an avian HEV mutant with a deletion of the entire HVR region (aaΔ557-603) using the avian HEV infectious cDNA clone as the backbone. After confirming the viability of the complete HVR-deletion mutant in LMH cells, SPF chickens were intrahepatically inoculated with capped RNA transcripts generated from the mutant. None of the chickens inoculated with the complete HVR-deletion mutant showed evidence of HEV infection, indicating that drastic reduction in replication levels due to complete HVR deletion has resulted in the loss of virus infectivity. The results indicated that HVR may have critical residues that may interact with viral/and or host factors and modulate the replication efficiency of HEV. In the final part of the dissertation research, we sought to determine if the variable sequences of HVR are genotype-specific for in vitro virus replication. By using the genotype 1 human HEV as the backbone, we swapped the HVR of genotype 1 human HEV with the HVRs of the genotype 3 swine HEV and the distantly-related avian HEV to construct two inter-genotypic chimeras, pSKHEV2-Sw and pSKHEV2-Av. Similarly, by using the genotype 3 swine HEV as the backbone, the HVR of genotype 3 swine HEV was swapped with the HVR of genotype 1 human HEV to construct the chimera, pSHEV3-Hu. The viability of these chimeras was tested in Huh7 cells that are permissive for HEV replication. Immunofluorescence assay (IFA) with anti-HEV antibodies revealed that all the three chimeras were replication-competent in Huh7 cells. The infectivity of these chimeras was subsequently evaluated in HepG2 cells. The results showed that exchange of the HVR between different genotypes of mammalian HEVs does not abolish the replication competency and infectivity of HEV. This finding suggests that HVR is not genotype-specific with respect to viral replication and infectivity. The absence of detectable viral antigen in HepG2 cells infected with chimera pSKHEV2-Av suggested a functional incompatibility of the HVR of avian HEV in the mammalian HEV genome. In summary, we identified a highly variable sequence, HVR, in the ORF1 of the HEV genome, and the sequences of the HVR vary significantly among HEV strains of different genotypes. We found that the HVR contain sequences that are dispensable for virus infectivity both in vitro and in vivo. Deletion analysis of HVR revealed that the region may play a role in modulating the replication efficiency of HEV RNA by interacting with viral and/or host factors. Finally, we demonstrated that HVR is not genotype-specific for virus replication and the region can be functionally replaced between mammalian HEV genotypes for virus replication and virion production in vitro. The results from this dissertation research have important implications for better understanding the biology and mechanism of HEV replication and may aid in our efforts to eventually develop a modified live-attenuated vaccine against HEV.
Ph. D.
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Menezes, Adriana Pereira Domarques de. "Modificações em proteínas induzidas por compostos eletrofílicos. possível papel em esclerose lateral amiotrófica." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-26042018-142018/.

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Danos em biomoléculas podem ocorrer a partir de uma interação direta entre as biomoléculas e espécies reativas de oxigênio e nitrogênio como também, pela reação de produtos secundários dessas espécies como eletrófilos gerados na peroxidação lipídica. Alguns desses produtos secundários possuem estabilidade química maior que as espécies reativas das quais foram derivadas e podem se ligar covalentemente as biomoléculas comprometendo o funcionamento normal das mesmas. Portanto, modificações em proteínas por aldeídos gerados na lipoperoxidação têm sido investigadas por suas implicações com desordens patológicas relacionadas à agregação proteica, e modificações em diversas vias de sinalização amplificando os efeitos deletérios em sistemas biológicos. Os objetivos desse trabalho foi contribuir na elucidação dos mecanismos moleculares associados ao desenvolvimento da esclerose lateral amiotrófica (ELA) através da identificação, caracterização e quantificação de modificações póstraducionais em proteínas pelos aldeídos 4-hidroxi-2-hexenal (HHE) e trans-4-hidroxi-2-nonenal (HNE) in vitro (citocromo c) e in vivo (modelo ELA) a partir de técnicas de Western blot, imunoprecipitação e espectrometria de massa com abordagem proteômica de \"shotgun\" em ratosSOD1G93A modelo de esclerose lateral amiotrófica (ELA). Estudos com citocromo c mostraram a ligação dos aldeídos ao citocromo c e mecanismos de reação foram propostos. Foram encontrados seis peptídeos modificados por HHE e um para o HNE, e o peptídeo TGPNLHGLFGR se mostrou modificado pelos dois aldeídos paralelamente. Foi demonstrado que a histidina 33 é um \"hot spot\" frente as adições pelos aldeídos. Nas análises por western blot das proteínas ligadas a aldeídos foi possível observar uma tendência de aumento na concentração de proteínas ligadas ao HNE nos animais ELA, mais acentuada nas amostras de 70 dias comparadas ao controle. Com relação aos resultados obtidos com HHE tanto os animais pré-sintomáticos quanto os sintomáticos não apresentaram diferenças de HHE-proteína, tantonos controles quanto nos animais ELA. Nas amostras dos animais sintomáticos não detectamos diferença significativa na concentração de aldeído-proteína entre os grupos. Já as análises proteômicas revelaram 24 proteínas diferencialmente expressas, com destaque para proteínas com os maiores valores de significância (p-value), como a ubiquitina no grupo dos pré- sintomáticos e a neurogranina, no grupo dos animais sintomáticos e várias proteínas de metabolismo energético, de neurofilamentos, proteínas de processos redox e proteínas ligadas o metabolismo de cálcio (fundamentais na fisiopatologia em ELA). Algumas proteínas importantes foram encontradas com exclusividades nos grupos pré-sintomáticos e sintomáticos pelo diagrama de Venn. Com relação a proteínas modificadas pelos aldeídos, foram encontradas algumas relevantes como a proteína 2 de interação com a polimerase delta que foi modificada por HNE via adição de Michael encontrada nos animais ELA pré-sintomáticos e sintomáticos, a catalase que foi encontrada modificada por HNE via base de Schiff apenas nos ELA pré- sintomáticos, e a tiol redutase induzível por interferon gama no grupo dos animais ELA sintomáticos. Com relação a proteínas modificadas por HHE, foram encontradas a Janus quinase e proteína 3 de interação com microtúbulo, modificadas tanto por adição de Michael quanto via base de Schiff nos animais ELA sintomáticos. É interessante ressaltar que algumas modificações encontradas em proteínas não caracterizadas podem indicar proteínas novas ainda não descritas como modificadas por esses aldeídos. Os resultados mostram que algumas das proteínas modificadas por HNE e HHE encontradas neste trabalho, estão relacionadas ao estresse redox, vias metabólicas energéticas, proteínas envolvidas na resposta a danos oxidativos, e processos inflamatórios. Tais modificações ocorrem não só no modelo de neurodegeneração, mas foram previamente descritas em outros processos patológicos, como doença cardiovascular, lesão hepática por uso crônico de álcool.
Damage to biomolecules can occur from a direct interaction between biomolecules and reactive of oxygen and nitrogen species as well as from the reaction of secondary products of these species as electrophiles generated in lipid peroxidation. Some of these by-products have greater chemical stability than the derived reactive species and can bind to biomolecules compromising their normal function. Therefore, protein modifications by aldehydes generated during lipoperoxidation have been investigated for their implications with pathological disorders related to protein aggregation and modifications in signaling pathways amplifying the deleterious effects in biological systems. The aim of this work was to contribute to the elucidation of the molecular mechanisms associated with the development of amyotrophic lateral sclerosis (ALS) through the identification, characterization and quantification of posttranslational modifications in proteins by 4-hydroxy-2-hexenal (HHE) and trans-4-hydroxy-2- nonenal (HNE) in vitro, cytochrome c, and in vivo, rat model (SOD1G93A) of amyotrophic lateral sclerosis (ALS), throught Western blot techniques, and mass spectrometry with shotgun proteomics approach. The results showed the binding of aldehydes to cytochrome c. Six peptides were modified by HHE and one by HNE. The peptide TGPNLHGLFGR was modified by the two aldehydes. Histidine 33 has been shown to be a hot spot against aldehydes additions. By western blot analysis of the aldehyde-bound proteins, it was possible to observe a tendency of increase in the concentration of HNE-bound proteins in the ALS animals, more pronounced in the samples of 70 days compared to control samples. Regarding the results obtained with HHE, both pre-symptomatic and symptomatic animals did not show HHE-protein differences, both in controls and in ALS animals. We did not detect a significant difference in the aldehyde-protein concentration between the groups in the samples of the symptomatic animals. Proteomic analysis revealed 24 differentially expressed proteins, with emphasis on proteins with thehighest values of significance (p-value), such as the ubiquitin in the pre-symptomatic group and neurogranin in the group of the symptomatic animals and several proteins of the energetic metabolism pathways, neurofilaments, proteins of redox processes and proteins linked to calcium metabolism (fundamental in the pathophysiology of ALS). Some important proteins were found exclusivity in the pre-symptomatic and symptomatic groups by the Venn diagram. With regard to aldehyde-modified proteins, some relevant ones such as Delta-2 polymerase interaction protein, that was modified by HNE via the addition of Michael found in presymptomatic and symptomatic ELA animals, catalase that was found to be modified by HNE via Schiff\'s base only in pre-symptomatic ALS, and gamma interferon-inducible thiol reductase in the group of symptomatic ALS animals. Janus kinase and microtubule interaction protein 3, were found to be modified by Michael addition and Schiff base pathway respectively in symptomatic ALS animals. It is interesting to note that some modifications found in uncharacterized proteins may indicate new proteins not yet described as modified by these aldehydes. The results show that some of the proteins modified by HNE and HHE found in this work are related to redox stress, energetic metabolic pathways, proteins involved in the response to oxidative damage, and inflammatory processes. Such modifications occur not only in the neurodegeneration model, but were previously described in other pathological processes, such as cardiovascular disease, liver injury due to chronic alcohol use
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Amann, Freya. "„Hie Bayern, hie Preußen“?" Diss., Ludwig-Maximilians-Universität München, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-155787.

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Chen, Bety. "Estudo dos polimorfismos das regiões hipervariáveis HV1 e HV2 do DNA mitocondrial da população brasileira aplicado à identificação humana." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-19032015-095415/.

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Com o intuito de avaliar os polimorfismos de mtDNA e a diversidade genética na população brasileira, foram estudados 84 indivíduos não aparentados: 49 caucasóides e 35 negróides da região sudeste do Brasil. As amostras de sangue obtidas por punção da polpa digital foram colocadas em papel de filtro e o mtDNA extraído pelo método orgânico. Foram amplificadas as regiões hipervariáveis HV1 a partir do nucleotídeo 16.051 até 16.365 e HV2 entre os nucleotídeos 71 e 340. O fragmento foi purificado e após a reação de seqüenciamento, as fitas sense e anti-sense foram alinhadas com a seqüência de Anderson e sobrepostas para confirmação. Foram encontradas 108 posições contendo transições, 15 transversões, 11 deleções e 4 inserções. Nove regiões apresentaram duas variantes de seqüência polimórfica. A maioria das seqüências foi observada uma única vez e em 84 indivíduos foram observados 80 haplótipos distintos. O índice de diversidade genética e a probabilidade de semelhança entre duas seqüências escolhidas ao acaso foram respectivamente de 0,9714 e 0,0286 para os negróides e de 0,9788 e 0,0212 para os caucasóides. Ao realizar análise pareada dos haplótipos, a média de nucleotídeos diferentes entre as seqüências foi de 14,36 ± 5,68 bases em um total de 3.486 pares comparados, indicando uma alta diversidade entre haplótipos nesta população. Os resultados demonstraram que o mtDNA é informativo para identificação humana e o conhecimento da freqüência dos haplótipos na população de interesse tem utilidade significativa na aplicação Forense, principalmente para se avaliar estatisticamente os resultados, fornecendo maior precisão, exatidão e dados contundentes nas investigações.
In order to evaluate the mtDNA polymorphism and demonstrate the sequence diversity in Brazilians, we established a database of 84 unrelated individuals, 49 Caucasians and 35 negroids from the southeast of Brazil. The samples were collected on a whatman paper by finger punction, the mtDNA was extracted by organic method and hipervariable regions, HV1 from 16.051 to 16.365 bp and HV2 from 71 to 340 bp were amplified. Both sense and anti-sense strands were sequenced. When compared to Anderson sequence, 108 transitions, 15 transversions, 11 deletions and 4 insertions were found. Nine positions exhibited two variants of polymorphic sequence. The majority of the sequences were observed once, and in 84 sequences, 80 haplotypes were observed. The sequence diversity and the probability for two individuals randomly matching over two hypervariable regions were 0.9714 and 0.0286 for persons of color and 0.9788 and 0.0212 for Caucasians. In pair wise comparison, the mean sequence difference of 14,36 ± 5,68 nucleotides over 3,486 pairs compared, indicates a high diversity in this population. The data demonstrates that mtDNA sequencing can be informative in forensic cases, but it is of crucial importance to know the frequency of the mtDNA haplotypes to statistically evaluate the results.
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Sadhukhan, Sushabhan. "Metabolism & Signaling of 4-Hydroxyacids: Novel Metabolic Pathways and Insight into the Signaling of Lipid Peroxidation Products." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1339171892.

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Sen, Pallavi. "I Don’t Have Confirmation, I Only Have Context." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4236.

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Books on the topic "HVE"

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Nandā ke Jāgara: Suphala hve jāya tumārī jatarā. Deharadūna, Uttarākhaṇḍa: Vinasara Pabliśiṅga Kampanī, 2013.

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Vebjørn, Rogne, ed. Århundrets hvem, hva, hvor. [Oslo]: Schibsted, 1999.

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Norland, Andreas. Hvem, hva, hvor 1905. Oslo: Schibsted, 2004.

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Kleven, Hans I. Ny teknologi: For hvem og for hva. Oslo: Falken, 1988.

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Clifford, Mette. Hvem vet hva om internasjonalt samarbeid og utviklingshjelp. 4th ed. [Oslo]: Departementet for utviklingshjelp (DUH), 1988.

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Pong-sŭng, Sin, ed. Nanse ŭi kʻal. Sŏul-si: Sŏn, 2006.

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Pong-sŭng, Sin, ed. Nanse ŭi kʻal. Sŏul-si: Sŏn, 2006.

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Kåre, Vassenden, and Norway Statistisk sentralbyrå, eds. Innvandrere i Norge: Hvem er de, hva gjør de og hvordan lever de? Oslo: Statistisk sentralbyrå, 1997.

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Hemingway, Ernest. To have and to have not. New York: Scribner/Macmillan, 1988.

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Bay, Gunnar. Hva' nu? Hva' så? Virum: Greens forlag, 2010.

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Book chapters on the topic "HVE"

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "Setting the Stage for Hive: Hadoop." In Practical Hive, 1–22. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_1.

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "Hive Security." In Practical Hive, 233–43. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_10.

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "The Future of Hive." In Practical Hive, 245–47. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_11.

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "Building a Big Data Team." In Practical Hive, 249–52. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_12.

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "Hive Functions." In Practical Hive, 253–62. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_13.

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "Introducing Hive." In Practical Hive, 23–35. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_2.

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "Hive Architecture." In Practical Hive, 37–48. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_3.

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "Hive Tables DDL." In Practical Hive, 49–76. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_4.

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "Data Manipulation Language (DML)." In Practical Hive, 77–98. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_5.

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Shaw, Scott, Andreas François Vermeulen, Ankur Gupta, and David Kjerrumgaard. "Loading Data into Hive." In Practical Hive, 99–114. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-0271-5_6.

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Conference papers on the topic "HVE"

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Grimes, Wesley D. "Programming FORTRAN Applications for HVE." In International Congress & Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1996. http://dx.doi.org/10.4271/960889.

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Neptune, James A. "Overview of an HVE Vehicle Database." In International Congress & Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1996. http://dx.doi.org/10.4271/960896.

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Grimes, Wesley D. "Using ATB Under the HVE Environment." In SAE International Congress and Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1997. http://dx.doi.org/10.4271/970967.

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Fay, Richard J., and Don Siddall. "Using Imported Objects And Images in HVE." In International Congress & Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1998. http://dx.doi.org/10.4271/980019.

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Day, Terry D. "An Overview of the HVE Vehicle Model." In International Congress & Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1995. http://dx.doi.org/10.4271/950308.

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Day, Terry D. "An Overview of the HVE Human Model." In International Congress & Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1995. http://dx.doi.org/10.4271/950659.

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Day, Terry D. "An Overview of the HVE Developer's Toolkit." In International Congress & Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1994. http://dx.doi.org/10.4271/940923.

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Metz, L. Daniel. "Simulation of Transient Maneuver Hydroplaning Events Using HVE." In SAE 2014 World Congress & Exhibition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2014. http://dx.doi.org/10.4271/2014-01-0122.

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Huang, Guozhen George. "Taxing a highly virtualised enterprise (HVE) in New Zealand." In Annual International Conference on Cloud Computing and Virtualization (CCV 2010). Global Science and Technology Forum, 2010. http://dx.doi.org/10.5176/978-981-08-5837-7_143.

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Leonard, M. Mark, Jeffrey J. Croteau, Stephen M. Werner, Steven M. Tuskan, and John L. Habberstad. "HVE EDSMAC4 Trailer Model Simulation Comparison with Crash Test Data." In SAE 2000 World Congress. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2000. http://dx.doi.org/10.4271/2000-01-0468.

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Reports on the topic "HVE"

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Bergene, Anne Cecilie, Ingar Brattbakk, Cathrine Egeland, and Arild Henrik Steen. Norsk arbeidsliv 2015. «Det nye arbeidslivet»: hvem, hva, hvor? Oslo: Arbeidsforskningsinstituttet, 2015. http://dx.doi.org/10.7577/afi/fou/2015/5.

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Crawford, Claire. Socio-economic gaps in HE participation: how have they changed over time? IFS, November 2012. http://dx.doi.org/10.1920/bn.ifs.2012.00133.

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Lee, Jung Eun. The Hive. Ames: Iowa State University, Digital Repository, November 2015. http://dx.doi.org/10.31274/itaa_proceedings-180814-1269.

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al-Muqdad, Omar. Refugees Have Few Options, We Have a Lot More. Center for Migration Studies, May 2019. http://dx.doi.org/10.14240/cmsesy053019.

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NMR Publikation. Hver er árangur hnattvæðingarverkefnisins? Nordisk Misterråd, January 2013. http://dx.doi.org/10.6027/anp2012-770.

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Carroll, H. B. Jr. Characteristics of H.E. and H.E. systems. Quarterly report, April 1964--June 1964. Office of Scientific and Technical Information (OSTI), September 1997. http://dx.doi.org/10.2172/527937.

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Khan, B. Zorina. ‘To Have and Have Not’: Are Rich Litigious Plaintiffs Favored in Court? Cambridge, MA: National Bureau of Economic Research, February 2015. http://dx.doi.org/10.3386/w20945.

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Toor, A., T. Donich, and P. Carter. High velocity impact experiment (HVIE). Office of Scientific and Technical Information (OSTI), February 1998. http://dx.doi.org/10.2172/303456.

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Barro, Robert, and Rachel McCleary. Which Countries Have State Religions? Cambridge, MA: National Bureau of Economic Research, April 2004. http://dx.doi.org/10.3386/w10438.

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Fullerton, Don. Why Have Separate Environmental Taxes? Cambridge, MA: National Bureau of Economic Research, December 1995. http://dx.doi.org/10.3386/w5380.

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