Relevant bibliographies by topics / Humoral immune reponse

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  1. Journal articles
  2. Dissertations / Theses
  3. Books

Academic literature on the topic 'Humoral immune reponse'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Humoral immune reponse"

1

Fest, Stefan, Kerstin Hilt, Nicole Huebener, Yan Zeng, Anne Strandsby, Silke Weixler, Gerhard Gaedicke, et al. "GD2 Peptide Mimotope DNA Vaccines for Anti-Neuroblastoma Immunotherapy." Blood 104, no. 11 (November 16, 2004): 1350. http://dx.doi.org/10.1182/blood.v104.11.1350.1350.

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Abstract The tumor-associated antigen disialoganglioside-GD2 is expressed on neuroblastoma and melanoma and is an established target for passive immunotherapy. The aim of this study was to develop an active immunization strategy leading to the induction of a humoral anti-GD2 immune response. However, carbohydrates and glycolipids are T cell-independent antigens (TI) and usually evoke a poor immune response in tumor-bearing hosts. Here, we describe the identification, characterization and in vivo efficacy of cyclic peptides mimicking the structure of glycolipid GD2, i.e. GD2 mimotopes, in order to overcome T-cell independency. First, GD2 peptide mimotopes were identified by biopanning experiments of a phage-display library displaying circular decapeptides against the human/mouse chimeric anti-GD2 antibody (Ab) ch14.18. Thirteen independent phage clones were isolated which bind to ch14.18 with high specificity. Competitive binding of phages expressing GD2 peptide mimotopes to ch14.18 antibody revealed two superior peptide candidates, mimotope A (MA) and and mimotope D (MD), which were subjected to further evaluation. Second, two plasmid DNA minigene vaccines were generated by overlapping PCR encoding for MA and MD, respectively. The plasmids were based on pSecTag2-A also including a kappa leader sequence, a T-cell helper epitope from HIV-1 gp 120 (T1) and a myc-tag. Minigene expression was demonstrated following transfection of COS-7 cells in western-blots and GD2 mimikry was determined in solid phase ELISA experiments. Third, the efficacy of these mimotope DNA vaccines to induce a tumor protective anti-GD2 immune response was tested in the syngeneic NXS2 model of neuroblastoma expressing ganglioside GD2. The DNA vaccination was accomplished with attenuated Salmonella typhimurium (SL 7207) used as an oral vaccine carrier. Only mice receiving the mimotope DNA vaccines revealed a decrease in primary tumor growth by 50% and a dramatic reduction of spontaneous liver metastases with a mean liver weight of 1g in both groups (MA and MD) in contrast to negative controls (3g). Interestingly, mice immunized with KLH conjugated peptide mimotopes A and D revealed an increased rate of s.c. tumor growth and spontaneous liver metastasis with average liver weights of 5 (MA) and 7 (MD), respecively, suggesting the induction of tolerance using this peptide vaccine approach. Finally the highest anti-GD2 humoral immune response was observed in sera of mice from both GD2 mimotope DNA vaccine groups, consistent with the anti-tumor reponse observed in vivo. Based on these data, we belive that GD2 mimotope DNA vaccines may provide a useful strategy for active immunization against neuroblastoma.
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2

Chiuppesi, Flavia, Jenny Nguyen, Soojin Park, Heidi Contreras, Mindy Kha, Zhuo Meng, Teodora Kaltcheva, et al. "Multiantigenic Modified Vaccinia Virus Ankara Vaccine Vectors To Elicit Potent Humoral and Cellular Immune Reponses against Human Cytomegalovirus in Mice." Journal of Virology 92, no. 19 (July 25, 2018). http://dx.doi.org/10.1128/jvi.01012-18.

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The development of a human cytomegalovirus (HCMV) vaccine to prevent congenital disease and transplantation-related complications is an unmet medical need. While many HCMV vaccine candidates have been developed, partial success in preventing or controlling HCMV infection in women of childbearing age and transplant recipients has been observed with an approach based on envelope glycoprotein B (gB). We introduce a novel vaccine strategy based on the clinically deployable modified vaccinia virus Ankara (MVA) vaccine vector to elicit potent humoral and cellular immune responses by multiple immunodominant HCMV antigens, including gB, phosphoprotein 65, and all five subunits of the pentamer complex. These findings could contribute to development of a multiantigenic vaccine strategy that may afford more protection against HCMV infection and disease than a vaccine approach employing solely gB.
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Dissertations / Theses on the topic "Humoral immune reponse"

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Gibb, Alison L. "Studies on human complement component C4." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358680.

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2

WACHSMANN, LEVY DOMINIQUE. "Immunite des muqueuses : etude de la reponse immune locale apres stimulation orale par des antigenes proteiques et polysaccharidiques de streptococcus mutans." Strasbourg 1, 1986. http://www.theses.fr/1986STR13125.

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3

Gougerot-Pocidalo, Marie-Anne. "Processus oxydants et reponses immunitaires : mecanismes biochimiques et cellulaires." Paris 7, 1988. http://www.theses.fr/1988PA077063.

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Mahana, Wahib. "Etude de la reconnaissance des antigenes du soi par les autoanticorps naturels." Paris 7, 1987. http://www.theses.fr/1987PA077130.

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5

Brunet, Jean-François. "Recherche et caractérisation des activités anticorps des liquides kystiques des tumeurs cérébrales." Université Joseph Fourier (Grenoble ; 1971-2015), 1994. http://www.theses.fr/1994GRE10222.

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Le but de cette these est d'etudier les reponses immunes humorales intracerebrales lors de processus tumoraux cerebraux. Elle comprend donc une introduction sur les interactions entre les systemes immunitaire et nerveux central d'une part et sur les tumeurs cerebrales d'autre part. Puis une presentation du materiel biologique donne notamment les raisons du choix des liquides kystiques pour cette etude immunologique. Le troisieme chapitre decrit les etudes qualitative et quantitative des immunoglobulines des liquides kystiques des tumeurs cerebrales. Les deux chapitres suivants presentent la recherche des activites anticorps des liquides kystiques dirigees respectivement contre le tissu cerebral non tumoral et contre les tissus cerebraux tumoraux, par immunohistochimie et par immunotransfert. Les effets des immunoglobines de classe g des liquides kystiques, sur des lignees cellulaires, sont decrits dans le sixieme chapitre. Puis les protocoles developpes pour la purification des antigenes reconnus par les liquides kystiques sont exposes, avant une discussion generale sur l'ensemble des resultats
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6

Shidani, Babak. "Effet de la cyclosporine a sur le systeme immunitaire de la souris." Paris 7, 1987. http://www.theses.fr/1987PA077159.

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7

Florentin, Irène. "Caracterisation fonctionnelle comparative de substances immunomodulatrices." Paris 6, 1987. http://www.theses.fr/1987PA066374.

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8

BESSIERES, CATHALA MARIE-HELENE. "Contributon dans un but diagnostique a l'etude de la reponse immune humorale au cours des toxoplasmoses acquises et congenitales." Toulouse 3, 1991. http://www.theses.fr/1991TOU30170.

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Ce travail, axe sur le depistage de la toxoplasmose congenitale, fait le point sur les methodes utilisees pour le diagnostic. Confronte a des choix de techniques et a des difficultes d'interpretation, le biologiste doit avoir une meilleure connaissance de la reponse immune. Les methodes immunoenzymatiques ont ete evaluees et comparees a l'immunofluorescence. Il est ainsi demontre que les cinetiques des anticorps igg reveles par ces deux tests sont differentes. L'elisa igg ne se revele pas plus sensible; des igm non specifiques interferent et des anticorps igm persistent au-dela du stade aigu de l'infection. Des schemas d'interpretation de la serologie sont proposes. L'interet du diagnostic antenatal est souligne. L'isolement du parasite par inoculation a des cellules en culture ameliore ce diagnostic. En outre, par la technique d'immunotransfert, deux preparations d'antigenes solubles, impliquees dans les reactions elisa, ont ete analysees, une correspondant a un extrait lytique, l'autre ou exo-antigene preparee a partir de surnageants de culture de toxoplasma gondii. Cette derniere pourrait etre utilisee comme solution antigenique car elle est d'obtention facile, evite l'inoculation du parasite a la souris et se revele d'une bonne antigenicite. De plus, l'apport pour le diagnostic de la detection des anticorps iga a ete etudie. Par immunotransfert, ils revelent des antigenes reconnus par les igg et igm specifiques. La mise en evidence des iga permet de mieux apprecier le stade evolutif d'une toxoplasmose acquise et ameliore le depistage de la toxoplasmose congenitale
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9

ECOCHARD, DENISE. "Immunite humorale au cours des infections lentivirales : caracterisation de la reponse anticorps induite par le virus visna-maedi (lentivirus apparente aux virus de l'immunodeficience acquise)." Lyon 1, 1990. http://www.theses.fr/1990LYO1M168.

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10

Gruaz-Guyon, Anne. "Reponse anticorps et protection locale induites par des immunogenes synthetiques selectionnes dans la sequence de la toxine cholerique : immunisation systemique et orale." Paris 6, 1987. http://www.theses.fr/1987PA066409.

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Proposition d'une sequence immunogenique devant contenir des tetrapeptides absents de proteines de l'hote (ou presentant peu d'homologie avec les sequences contenues dans les banques de donnees) en association avec les sequences capables de reconnaitre les antigenes du complexe majeur d'histocompatibilite
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Books on the topic "Humoral immune reponse"

1

M, Snapper Clifford, ed. Cytokine regulation of humoral immunity: Basic and clinical aspects. Chichester: J. Wiley, 1996.

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2

Snapper, Clifford M. Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects. Wiley & Sons, Incorporated, John, 2008.

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3

Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects. Wiley, 1996.

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