Academic literature on the topic 'Humigard'

Background Perioperative hypothermia during laparoscopy for bowel resection is a risk factor for postoperative medical complications and surgical wound infections. Despite various warming methods used during surgery, a significant number of patients experience perioperative hypothermia. Use of dry, unwarmed insufflation carbon dioxide (CO2) during laparoscopic procedures may contribute to this problem. Evidence exists that the HumiGard device, which humidifies and heats CO2 for insufflation, can reduce the risk of perioperative hypothermia. Objective The aim is to determine if insufflation with warmed, humidified CO2 using the HumiGard device, alongside standard perioperative warming techniques, can improve patient recovery, including pain, surgical site infections, complications, and the use of analgesia compared with standard care alone. Methods The study is a multicenter, randomized, blinded (patient, surgeon, and assessor), sham device-controlled, parallel group-controlled trial of 232 patients. The study aims to recruit patients undergoing elective laparoscopic, segmental, or total colectomy. Patients will be randomized to receive HumiGard plus standard care or standard care alone (1:1 ratio). The primary outcome is patient-reported quality of recovery, measured by the validated QoR-40 (quality of recovery) questionnaire, from baseline to postoperative day 1. Secondary outcomes include postoperative pain, the incidence of hypothermia, and the rate of postoperative complications. Results The information gathered during a small-scale service evaluation at a single hospital was used to inform this study protocol. Before applying for a grant for this full randomized controlled trial, the authors will conduct a feasibility study of 40 patients to ensure that the protocol is feasible and to inform our sample size calculation. Conclusions The randomized controlled trial is designed to provide high-quality evidence on the effectiveness of the HumiGard device in potentially reducing the risk of perioperative hypothermia in patients scheduled for laparoscopic colectomy. The results will be used to improve the maintenance of adequate patient body temperature during surgery. International Registered Report Identifier (IRRID) PRR1-10.2196/14533

Background: Cool and dry gas insufflation during laparoscopy induces hypothermia and cytokine increase, with significant perioperative morbidity. Our aim was to assess if warmed and humidified CO2 insufflation with HumiGard™ device can achieve significant benefits over standard insufflation in terms of risk of hypothermia, cytokine response, blood gases, and intra- and postoperative parameters, in the setting of robot-assisted radical prostatectomy (RARP). Methods: This was a prospective, randomized controlled clinical trial. Sixty-four patients with prostate cancer undergoing RARP were randomized to receive warmed and humidified CO2 insufflation with HumiGard device, plus hot air warming blanket (treatment group, H + WB), or standard CO2 insufflation, plus hot air warming blanket (control group, WB). Body core temperature (BCT), plasma levels of IL-6 and TNF-α, pain scores, and intraoperative parameters were recorded. The data were analyzed according to the Bayesian paradigm. Results: Intraoperative BCT increased in both groups during surgery, with a statistically significant difference favoring group H + WB, ending at 0.2°C higher on average than group WB. No difference across groups was shown for cytokine levels. Blood gas parameters were not affected by warmed CO2 insufflation. No statistical differences were noted for pain scores and the other intra- and postoperative parameters. Conclusions: During RARP, warm and humidified CO2 insufflation with the HumiGard device was more effective than the standard CO2 insufflation in maintaining the patient’s heat homeostasis, even if the difference was minimal. No imbalances were detected on blood gas analyses. No benefit could be shown in terms of cytokine levels and pain scores.

Abstract Introduction Hypothermia is defined as a decrease in body core temperature to below 36 °C. If intraoperative heat-preserving measures are omitted, a patientʼs temperature will fall by 1 – 2 °C. Even mild forms of intraoperative hypothermia can lead to a marked increase in morbidity and mortality. The temperature of the insufflation gas is usually disregarded in the treatment and prevention of hypothermia. This study was conducted to investigate the effect of body-temperature and humidified CO2 on the intraoperative temperature profile and avoidance of hypothermia in laparoscopic surgery. Material and Methods In this retrospective, non-randomised case control study, 110 patients whose planned operation lasted at least 60 minutes were identified from 376 patients by means of an algorithm. Dry (20% humidity) CO2 at room temperature was insufflated in 51 patients (control group). 59 patients were insufflated with humidified (98% humidity) CO2 at body temperature (37 °C) (study group). These conditions were achieved with the HumiGard MR860 Surgical Humidification System (Fisher & Paykel Healthcare Limited, Auckland, New Zealand). The intraoperative temperature profile was evaluated by measurements every 10 minutes. Statistical analysis was performed with IBM® SPSS® Statistics 23.0.0. Results The intraoperative temperature in the control group fell steadily, while a continuous rise in temperature was observed in the study group. Warming was demonstrated in the study group with a start-end temperature difference of 0.09 °C, which differed significantly from the control group, in which it was − 0.09 °C (p = 0.011). The middle-end difference of 0.11 °C showed even higher significance in favour of the warmed gas (p = 0.003). The rate of hypothermia at the start of the operation fell from 50 to 36% in the study group and increased from 36 to 42% in the control group. Conclusion These results show that the use of body-temperature and humidified insufflation gas for laparoscopy can help to prevent intraoperative hypothermia.

Aim. To establish indicators of chemical composition, nutrition and energy intensity of spring triticale and seed pea in single-species and compatible crops depending on the ratio of components and fertilizers. Methods. Field, laboratory, mathematical-statistical, analytical. Results. The results of studies on the chemical composition of fodder annual binary agrophytocenoses with the participation of triticale spring pea seed with different ratios of components and different fertilizers on black earth soils of the Forest Steppe, which were conducted annually during 2020–2022, are shown. Conclusions. The inclusion of spring peas in the leguminous-cereal mixture of triticale improves the chemical composition of the feed, increasing the content of crude protein in the dry weight of the feed from 12.9 to 14.8−16.3%, or by 1.9−3.4%. At the same time, the content of protein and crude fat in the dry mass increases, the digestibility of the dry mass in vitro − by 3−7%, the nutritional value according to the content of feed units, the energy intensity according to the content of exchangeable energy − the supply of one feed unit with digestible protein − from 83 to 112−128 g, raw ash − by 0.3−0.6%, calcium − by 0.06−0.10%, magnesium − by 0.01−0.06%, Ca:P ratio and the content of crude fiber decreases by 1.5−3.1%, potassium and the K:(Ca+Mg) ratio. With the introduction of humigran in the dry mass of triticale, pea and their compatible crops, the content of crude protein increases by 1.4−2.0%, protein – by 0.4−1.9%, and N45P45K45 − by 1.4−2,5% and 0.8−2.4%. Under the influence of these fertilizers, the content of crude fat, fodder units, exchangeable energy, supply of digestible protein, raw ash of the fodder unit in the dry weight of the forage simultaneously increases, and the content of non-nitrogenous extractive substances decreases in all grass stands.

Abstract Background Optimized drug delivery systems are needed for intraperitoneal chemotherapy. The aim of this study was to develop a technology for applying pressurized intraperitoneal aerosol chemotherapy (PIPAC) under hyperthermic conditions (hPIPAC). Methods This is an ex-vivo study in an inverted bovine urinary bladder (IBUB). Hyperthermia was established using a modified industry-standard device (Humigard). Two entry and one exit ports were placed. Warm-humid CO2 was insufflated in the IBUB placed in a normothermic bath to simulate body thermal inertia. The temperature of the aerosol, tissue, and water bath was measured in real-time. Results Therapeutic hyperthermia (target tissue temperature 41–43 °C) could be established and maintained over 30 min. In the first phase (insufflation phase), tissue hyperthermia was created by insufflating continuously warm-humid CO2. In the second phase (aerosolization phase), chemotherapeutic drugs were heated up and aerosolized into the IBUB. In a third phase (application phase), hyperthermia was maintained within the therapeutic range using an endoscopic infrared heating device. In a fourth phase, the toxic aerosol was discarded using a closed aerosol waste system (CAWS). Discussion We introduce a simple and effective technology for hPIPAC. hPIPAC is feasible in an ex-vivo model by using a combination of industry-standard medical devices after modification. Potential pharmacological and biological advantages of hPIPAC over PIPAC should now be evaluated.

A development project was undertaken within the consortia formed by Polygon and AK-konsult. The aim of this project was to map out the impact of humidity leakages on the result of humidity measurements in concrete slabs according to the so-called RBK-method. It is behind the idea of this development project that the main purpose of this thesis can be derived from. For instance, an evaluation of already existing data material from a RBK-measurement has been done. A method has been retrieved in order to compare the trend of the measured values of the relative humidity with the trend of the expected values of the relative humidity during the drying process. The main goal has been to implement this method as an instrument to analyze the actual drying process. A survey study was undertaken among the employees of the consortia in order to point out the differences that arise during the installation of the measurement equipment prior to measurement according to the RBK-method. The result of the survey has been summarized and analyzed in purpose to catch a wider glimpse over the different kinds of variables that might have an impact on the result from a RBK-measurement. The outcome from the study of the existing measurement data shows that some of the measurement spots tends to dry out faster than the calculated drying process, while other spots indicates a slower drying process. Three of them actually pointed out that they were under humidity, which implies that they still hadn’t reached the stadium of moisture equilibrium with the concrete. The main reason behind the observed discrepancies might have its explanation in the fact that measurement wholes that have been subjected to a big humidity leakage. The consequence of measurement spots subjected to big humidity leakages, is that the measured value of the relative humidity turns out to be much lower than the actual level of the relative humidity in the concrete. An observation has been made in the plausibility analysis and in the Vaisalaproject that the normative equilibrium time exceeds the number of three days that’s been ordained by RBK. A further study of the normative equilibrium time can thereby be recommended to clarify if it still can be compatible with the different kinds of concrete classes of today.