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Relevant bibliographies by topics / Human thorax surrogate

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Academic literature on the topic 'Human thorax surrogate'

Author: Grafiati

Published: 25 May 2024

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Journal articles on the topic "Human thorax surrogate"

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Van Baelen, Karen, Gitte Zels, Maxim De Schepper, et al. "Abstract PO1-06-06: Underestimation of metastatic spread in patients with lobular breast cancer: results from the post-mortem tissue donation program UPTIDER." Cancer Research 84, no. 9_Supplement (2024): PO1–06–06—PO1–06–06. http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-06-06.

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Abstract Background: Invasive lobular carcinoma (ILC) accounts for 15% of all invasive breast cancers (BC) and has a peculiar metastatic spread in comparison to BC of no-special type. Since ILC is less likely to disrupt normal tissue architecture and is usually non-mass forming, imaging of ILC lesions entails many challenges. Insights into pathologic versus radiological metastatic invasion can lead to better diagnostic and monitoring tools for patients with ILC. Here, we compare microscopical findings during autopsy with clinical findings prior to death in patients with metastatic ILC included

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Hamel, Ronald P. "Surrogate Motherhood: The Ethics of Using Human Beings. By Thomas A. Shannon. New York: Crossroad, 1989. xi + 191 pages. $17.95." Horizons 16, no. 2 (1989): 408–9. http://dx.doi.org/10.1017/s0360966900040937.

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Yoganandan, Narayan, Alok Shah, Lewis Somberg, et al. "A Novel Paradigm to Develop Regional Thoracoabdominal Criteria for Behind Armor Blunt Trauma Based on Original Data." Military Medicine 188, Supplement_6 (2023): 598–605. http://dx.doi.org/10.1093/milmed/usad272.

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ABSTRACT Introduction For behind armor blunt trauma (BABT), recent prominent BABT standards for chest plate define a maximum deformation distance of 44 mm in clay. It was developed for soft body armor applications with limited animal, gelatin, and clay tests. The legacy criterion does not account for differing regional thoracoabdominal tolerances to behind armor-induced injury. This study examines the rationale and approaches used in the legacy BABT clay criterion and presents a novel paradigm to develop thoracoabdominal regional injury risk curves. Materials and Methods A review of the origin

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Kleine-Kohlbrecher, Daniela, Nadia Viborg Petersen, Michail Angelos Pavlidis, et al. "Abstract LB199: A personalized neoantigen vaccine is well tolerated and induces specific T-cell immune response in patients with resected melanoma." Cancer Research 83, no. 8_Supplement (2023): LB199. http://dx.doi.org/10.1158/1538-7445.am2023-lb199.

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Abstract Tumor mutations giving rise to neoantigens have recently emerged as promising targets for cancer immunotherapy. Vaccines delivering tumor-specific neoantigens have demonstrated favorable efficacy and safety results in numerous preclinical and early clinical studies. However, selecting therapeutically relevant neoantigens amongst the myriad of cancer mutations has proven challenging. To overcome this, we have developed a proprietary AI-based target discovery platform, PIONEER, with enhanced predictive performance and increased precision. The PIONEER top-ranked neoantigens were selected

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Monteiro Crozier, Thomas W., Martha Lopez-Yrigoyen, Helena Engman, et al. "Abstract LB201: ENIGMAC platform enables at-scale CRISPRi screenings for macrophage target discovery." Cancer Research 84, no. 7_Supplement (2024): LB201. http://dx.doi.org/10.1158/1538-7445.am2024-lb201.

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Abstract RNA sequencing has improved our understanding of cellular heterogeneity by providing in-depth transcriptome information at the single cell level. However, this “dataset infodemic” did not translate into an abundance of new validated targets due to the difficulties in performing gene-to-function studies. The main goal of the ENIGMAC™ discovery platform is to support gene-to-function studies and to deliver new validated macrophage targets. ENIGMAC™ combines custom, disease relevant assays and unique genome editing methods supported by multi-omics bioinformatics analyses yielding selecte

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Duvall, Jeremy R., Raghida A. Bukhalid, Naniye M. Cetinbas, et al. "Abstract 3503: XMT-2056, a HER2-targeted Immunosynthen STING-agonist antibody-drug conjugate, binds a novel epitope of HER2 and shows increased anti-tumor activity in combination with trastuzumab and pertuzumab." Cancer Research 82, no. 12_Supplement (2022): 3503. http://dx.doi.org/10.1158/1538-7445.am2022-3503.

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Abstract We present here a novel therapeutic agent, XMT-2056, that results in robust anti-tumor activity mediated by an immune response through targeted delivery of a STING agonist to the tumor microenvironment. By leveraging an antibody-drug conjugate (ADC) strategy, systemic administration of a STING agonist with tumor-targeted delivery can be achieved, potentially overcoming limitations of either intratumoral or intravenous administrations of unconjugated, small molecule STING agonists. XMT-2056 was generated through conjugation of Immunosynthen, a platform that employs a novel STING agonis

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Schwenck, Johannes, Dominik Sonanini, Walter Ehrlichmann, et al. "Abstract LB058: Imaging of CD8+ cytotoxic T-cells by Zr-89-Df-IAB22M2C PET/MRI: First clinical experience in patients with metastatic cancer." Cancer Research 82, no. 12_Supplement (2022): LB058. http://dx.doi.org/10.1158/1538-7445.am2022-lb058.

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Abstract CD8+ cytotoxic T cells are key players in anti-cancer immune responses as they destroy MHC class I-dependent tumor cells. Therefore, the spatial distribution of CD8+ cytotoxic T cells might represent an important surrogate for the response to cancer immunotherapy including immune checkpoint inhibitor therapy ICT. The radiolabeled minibody [89Zr]Zr-Df-IAB22M2C is characterized by a high affinity to human CD8 and was already investigated in a phase I study. Here, we present our first experience with the non invasive in vivo assessment of the whole body CD8 T cell distribution in cancer

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Updyke, Joel, Shubhmita Bhatnagar, Nitu Bhaskar та ін. "Abstract 1993: Sulfobutylether-β-cyclodextrin hydrogel microspheres delivering TLR 7/8 agonist for transarterial immunoembolization". Cancer Research 83, № 7_Supplement (2023): 1993. http://dx.doi.org/10.1158/1538-7445.am2023-1993.

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Abstract Drug-eluting bead transcatheter arterial chemoembolization (DEB-TACE) is a treatment procedure for liver cancer that involves the selective catheterization and subsequent embolization of tumor-feeding arteries with drug-eluting beads (DEBs). DEB-TACE elicits ischemic cell death in the embolized tumor while simultaneously delivering a local, sustained release of chemotherapy. We hypothesize that the application of DEBs loaded with an immunostimulatory adjuvant in the DEB-TACE procedure will promote local antigen presenting cells to utilize the antigens released by dying tumor cells to

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McKeon, Thomas P., Vicky Tam, Wei-Ting Hwang, Paul Wileyto, Karen Glanz, and Trevor M. Penning. "Abstract PR06: Geocoding and integrating multiple environmental exposomics sources: Assessing population hazard to lung carcinogens in 421 zip codes of a cancer center catchment area." Cancer Epidemiology, Biomarkers & Prevention 29, no. 9_Supplement (2020): PR06. http://dx.doi.org/10.1158/1538-7755.modpop19-pr06.

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Abstract To assess risk factors that contribute to lung cancer burden in the Abramson Cancer Center (ACC) catchment area, we integrated geospatial data of exposure to pollutants from publicly available EPA and NASA datasets. The study area covers the 421 zip codes that make up the 12 counties of the catchment area from which most of the ACC patients come. The counties include 5 that surround Philadelphia, 6 in New Jersey, and 1 in Delaware. Environmental exposure data, sourced from US-EPA Air Quality System (AQS) Data Mart, were focused on air pollutants since air pollution is recognized by th

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van den Bruele, Astrid Botty, Morgan Paul, Samantha M. Thomas, et al. "Abstract P3-05-20: Low 21-Gene Recurrence Score Is Not Associated with a High Axillary Nodal Burden in Post-Menopausal Women Presenting with a Clinically Negative Axilla." Cancer Research 83, no. 5_Supplement (2023): P3–05–20—P3–05–20. http://dx.doi.org/10.1158/1538-7445.sabcs22-p3-05-20.

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Abstract Background: The predictive and prognostic value of the 21-gene recurrence score (RS) has emphasized the importance of tumor biology and minimized the credence of a limited (1-3 positive) nodal burden. The practice changing results of RxPonder demonstrated that post-menopausal women with 1-3 positive lymph nodes (pN1) and a RS of ≤25 did not necessarily benefit from adjuvant chemotherapy. Given that RS influences adjuvant therapy decision-making more significantly than nodal status, it is unclear whether axillary staging with sentinel lymph node biopsy (SLNB) has a continued role in th

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Dissertations / Theses on the topic "Human thorax surrogate"

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Chaufer, Martin. "Développement d’un substitut physique de thorax humain et de son jumeau numérique dédiés à la prédiction du risque lésionnel lors d'impacts balistiques non pénétrants." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2023. http://www.theses.fr/2023UBFCA015.

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Au cours des dernières années, l'utilisation d'armes à létalité réduite a augmenté. Ces armes, conçues pour neutraliser des individus présentant un comportement dangereux, peuvent causer des blessures, voire la mort. Des mécanismes de lésions similaires sont observés lors de la déformation arrière des gilets pare-balles au cours d'impact avec projectiles d’arme à feu. Afin de protéger les citoyens et les forces de l’ordre, il est nécessaire de prévenir de tels scénarios. Or aujourd'hui peu d'outils sont disponibles pour aider au dimensionnement de tel équipements. Dans cette optique, ce travai

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Albert, Devon Lee. "Biomechanical Responses of Human Surrogates under Various Frontal Loading Conditions with an Emphasis on Thoracic Response and Injury Tolerance." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/100947.

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Frontal motor vehicle collisions (MVCs) resulted in 10,813 fatalities and 937,000 injuries in 2014, which is more than any other type of MVC. In order to mitigate the injuries and fatalities resulting from MVCs, new safety restraint technologies and more biofidelic anthropomorphic test devices (ATDs) have been developed. However, the biofidelity of these new ATDs must be evaluated, and the mechanisms of injury must be understood in order to accurately predict injury. Evaluating the biomechanical response, injury mechanisms, and injury threshold of the thorax are particularly important because

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Book chapters on the topic "Human thorax surrogate"

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Chaufer, Martin, Rémi Delille, Benjamin Bourel, et al. "The Use of Human Surrogate for the Assessment of Ballistic Impacts on the Thorax." In Dynamic Behavior of Materials, Volume 1. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-50646-8_18.

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Chaufer, Martin, Rémi Delille, Benjamin Bourel, et al. "Toward a Physical Human Thorax Surrogate Dedicated to Blunt Ballistic Impacts Based on FE Simulations." In Computer Methods in Biomechanics and Biomedical Engineering II. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-55315-8_26.

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"Outblooming Human Rights Violations in Surrogacy: Thorns Beneath the Rose." In Advancement of Human Rights in India: Contemporary and Emerging Challenges. SAGE Publications Pvt. Ltd, 2021. http://dx.doi.org/10.4135/9789354793134.n16.

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Conference papers on the topic "Human thorax surrogate"

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Shah, Chirag S., Jong B. Lee, Warren N. Hardy, and King H. Yang. "A Partially Validated Finite Element Whole-Body Human Model for Organ Level Injury Prediction." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61844.

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A finite element whole-body human model, which represents a 50th percentile male, was developed by integrating three detailed human component models previously developed at Wayne State University (WSU): a thorax model with detailed representation of the great vessels [1], an abdomen model [2], and a shoulder model [3]. This new model includes bony structures such as scapulae, clavicles, the vertebral column, rib cage, sternum, sacrum, and illium and soft tissue organs such as the heart, lungs, trachea, esophagus, diaphragm, kidneys, liver, spleen, and all major blood vessels including the aort

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Cesari, Dominique, and Robert Bouquet. "Behaviour of Human Surrogates Thorax under Belt Loading." In Stapp Car Crash Conference. SAE International, 1990. http://dx.doi.org/10.4271/902310.

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Yoganandan, Narayan, John R. Humm, Frank A. Pintar, Karen H. Brasel, Rodney W. Rudd, and Stephen A. Ridella. "Thoraco-Abdominal Deflection Responses of Post Mortem Human Surrogates in Side Impacts." In 56th Stapp Car Crash Conference. SAE International, 2012. http://dx.doi.org/10.4271/2012-22-0002.

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Serres, Jennifer L., Dan V. Jones, Rabih E. Tannous, Nathan Dau, and Cynthia A. Bir. "Evaluation of Lower Limb Injury Mitigation Techniques for High Velocity Impacts With the Mil-LX." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53269.

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Improvised Explosive Devices (IED) and landmines present a significant threat to mounted troops currently serving in Iraq and Afghanistan. As a result of these threats, a substantial number of lower limb injuries are sustained by service members. Due to this reality, a critical factor in military vehicle design is the mitigation of lower limb trauma. Past studies have shown that the standard Hybrid III and THOR-LX are not biofidelic in military axial loading conditions (up to 12 m/s). Both of these surrogates over predict axial forces compared to Post Mortem Human Specimens (PMHS) [1]. As a re

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Jaradat, Waseem, Joseph Hassan, Guy Nusholtz, Khalil Taraman, and Sanaa Taraman. "A Comparison Between Head Impact Response of Hybrid III and THOR-NT Dummy Heads in FMVSS201 Tests." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-16322.

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The impact response of the forehead of both the Hybrid III dummy and THOR dummy was designed to the same human surrogate data. Therefore, when the forehead of either dummy is impacted with the same initial conditions, the acceleration response and consequently the head impact criterion HIC should be similar. If the THOR dummy is used in the FMVSS 201 free motion headform tests, then when it strikes the interior trim of the vehicle, as prescribed by the FMVSS 201 procedure, the acceleration response should be similar to that of the Hybrid III, as long as only the forehead engages the vehicle in

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Albert, Devon L., Stephanie M. Beeman, and Andrew R. Kemper. "Assessment of Thoracic Response and Injury Risk Using the Hybrid III, THOR-M, and Post-Mortem Human Surrogates under Various Restraint Conditions in Full-Scale Frontal Sled Tests." In 62nd Stapp Car Crash Conference. SAE International, 2018. http://dx.doi.org/10.4271/2018-22-0001.

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