Relevant bibliographies by topics / Human thoracic intervertebral disc

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Human thoracic intervertebral disc'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Human thoracic intervertebral disc"

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Teufack, Sonia, Peter Campbell, Pranshu Sharma, Tim Lachman, Lawrence Kenyon, James Harrop, and Srinivas Prasad. "Thoracic Myelopathy Due to an Intramedullary Herniated Nucleus Pulposus: First Case Report and Review of the Literature." Neurosurgery 71, no. 1 (April 8, 2012): E199—E202. http://dx.doi.org/10.1227/neu.0b013e3182582cf1.

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Abstract BACKGROUND AND IMPORTANCE: Herniation of intervertebral discs is relatively common. Migration usually occurs in the ventral epidural space; very rarely discs migrate in the subdural space. No cases of intradural intramedullary disc have been reported in humans. CLINICAL PRESENTATION: A case of a herniated intervertebral disc directly into the spinal cord parenchyma is presented. The patient presented with 2 weeks of progressive bilateral lower extremity numbness and weakness, saddle hypoesthesia, urinary dysfunction and gait disturbance. Spine magnetic resonance imaging (MRI) with gadolinium revealed a solitary well-defined intramedullary lesion (T7-T8 level) with ring enhancement and focal cord expansion with significant surrounding edema. Metastatic workup and neural axis imaging was negative. A thoracic laminectomy and myelotomy was performed; the lesion was pearlescent and well circumscribed. It was densely adherent to the ventral pia and gross totally removed. Pathology was consistent with nucleus pulposus. CONCLUSION: Intradural intramedullary migration of a herniated intervertebral disc is extremely rare but should be considered in the differential. It may present in a variety of clinical scenarios, including thoracic myelopathy, and mimic intramedullary spinal cord tumor.
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Brown, P. J., G. L. D. Alterio, and D. Fews. "A case of invertebral disc degeneration and prolapse with Schmorl's node formation in a sheep." Veterinary and Comparative Orthopaedics and Traumatology 19, no. 03 (2006): 187–89. http://dx.doi.org/10.1055/s-0038-1632997.

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SummaryA Schmorl's node is the herniation of nucleus pulposus through the cartilaginous end plate of the vertebral disc into the body of the adjacent vertebra. Their formation is relatively common in people, and they may be symptomatic or asymptomatic. In contrast, there are few reported cases of Schmorl's nodes in non-human animals. This report describes a case of thoracic intervertebral disc degeneration, with Schmorl's node formation in a sheep.
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Guo, Li-Xin, Ee-Chon Teo, and Tian-Xia Qiu. "PREDICTION OF BIOMECHANICAL CHARACTERISTICS OF INTACT AND INJURED LOWER THORACIC SPINE SEGMENT UNDER DIFFERENT LOADS." Journal of Musculoskeletal Research 08, no. 02n03 (June 2004): 87–99. http://dx.doi.org/10.1142/s0218957704001259.

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In this study, the biomechanical roles of disc nucleus and ligaments of human lower thoracic spine (T10–T12) under different loads were investigated using finite element (FE) method. The T10–T12 FE model was developed and validated against the published results. The FE model was then modified accordingly to simulate the injured conditions of nucleus, ligaments and facets and loaded under different configurations to analyze the segmental gross responses and the stress distribution around the annulus circumference. The high first-principal stress of annulus at the posterolateral region has an important role on the disc annulus's tear and a flexion moment causes a high first-principal stress at posterolateral region, despite of the existence of ligaments. The study also shows that decompression in intervertebral discs can reduce the dilatation of annulus tears by 18% around the posterolateral regions of disc annulus. The disc nucleus and the posterior ligaments have important roles in resisting compression and flexion loads, respectively. The investigations in this paper not only supplement experimental research but are also helpful in the understandings of biomechanics of lower thoracic spine.
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Teo, Ee-Chon, Tian-Xia Qiu, Kai Yang, Hong-Wan Ng, and Kim-Kheng Lee. "BIOMECHANICAL EFFECT OF THORACIC POSTERIOR VERTEBRAL ELEMENTS ON PATTERNS OF THE LOCI OF INSTANTANEOUS AXES OF ROTATION IN SAGITTAL PLANE." Journal of Musculoskeletal Research 07, no. 03n04 (September 2003): 191–200. http://dx.doi.org/10.1142/s0218957703001095.

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The objective of this study was to investigate the effect of the thoracic posterior vertebral elements on the kinematics of T10–T11 motion segment in sagittal plane by assessing the locations and loci of the instantaneous axes of rotation (IARs) under flexion and extension pure moments using finite element (FE) method. The IAR has proven to be a useful parameter of vertebral motion and it is an indicator of spinal instability. An anatomically accurate FE model of thoracic T10–T11 functional spinal unit (FSU) was used to characterize the loci of centers of rotation for the intact T10–T11 FSU and disc body unit (without posterior vertebral elements) under flexion and extension pure moments. The centers of rotation predicted by the intact model and disc body unit of thoracic T10–T11 for both flexion and extension were directly below the geometrical center of the moving vertebra. However, the loci of the IARs were significantly affected by the posterior vertebral elements. The loci of instantaneous axes of rotation for the intact model were tracked superoanteriorly and inferoposteriorly for flexion and extension with rotation, respectively. While, for the disc body unit, the loci were detected to diverge lateroinferiorly from the mid-height of the intervertebral disc, they converge medio-inferiorly toward the superior endplate of the inferior vertebra T11 with increased moment. These findings may offer an insight to better understanding the kinematics of the human thoracic spine and provide clinically relevant information for the evaluation of spinal stability and implant devices functionality.
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Healy, Andrew T., Prasath Mageswaran, Daniel Lubelski, Benjamin P. Rosenbaum, Virgilio Matheus, Edward C. Benzel, and Thomas E. Mroz. "Thoracic range of motion, stability, and correlation to imaging-determined degeneration." Journal of Neurosurgery: Spine 23, no. 2 (August 2015): 170–77. http://dx.doi.org/10.3171/2014.12.spine131112.

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OBJECT The degenerative process of the spinal column results in instability followed by a progressive loss of segmental motion. Segmental degeneration is associated with intervertebral disc and facet changes, which can be quantified. Correlating this degeneration with clinical segmental motion has not been investigated in the thoracic spine. The authors sought to determine if imaging-determined degeneration would correlate with native range of motion (ROM) or the change in ROM after decompressive procedures, potentially guiding clinical decision making in the setting of spine trauma or following decompressive procedures in the thoracic spine. METHODS Multidirectional flexibility tests with image analysis were performed on thoracic cadaveric spines with intact ib cage. Specimens consisted of 19 fresh frozen human cadaveric spines, spanning C-7 to L-1. ROM was obtained for each specimen in axial rotation (AR), flexion-extension (FE), and lateral bending (LB) in the intact state and following laminectomy, unilateral facetectomy, and unilateral costotransversectomy performed at either T4–5 (in 9 specimens) or T8–9 (in 10 specimens). Image grading of segmental degeneration was performed utilizing 3D CT reconstructions. Imaging scores were obtained for disc space degeneration, which quantified osteophytes, narrowing, and endplate sclerosis, all contributing to the Lane disc summary score. Facet degeneration was quantified using the Weishaupt facet summary score, which included the scoring of facet osteophytes, narrowing, hypertrophy, subchondral erosions, and cysts. RESULTS The native ROM of specimens from T-1 to T-12 (n = 19) negatively correlated with age in AR (Pearson’s r coefficient = -0.42, p = 0.070) and FE (r = -0.42, p = 0.076). When regional ROM (across 4 adjacent segments) was considered, the presence of disc osteophytes negatively correlated with FE (r = −0.69, p = 0.012), LB (r = −0.82, p = 0.001), and disc narrowing trended toward significance in AR (r = −0.49, p = 0.107). Facet characteristics, scored using multiple variables, showed minimal correlation to native ROM (r range from −0.45 to +0.19); however, facet degeneration scores at the surgical level revealed strong negative correlations with regional thoracic stability following decompressive procedures in AR and LB (Weishaupt facet summary score: r = −0.52 and r = −0.71; p = 0.084 and p = 0.010, respectively). Disc degeneration was not correlated (Lane disc summary score: r = −0.06, p = 0.861). CONCLUSIONS Advanced age was the most important determinant of decreasing native thoracic ROM, whereas imaging characteristics (T1–12) did not correlate with the native ROM of thoracic specimens with intact rib cages. Advanced facet degeneration at the surgical level did correlate to specimen stability following decompressive procedures, and is likely indicative of the terminal stages of segmental degeneration.
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Tan, C. I., G. Neil Kent, A. G. Randall, S. J. Edmondston, and K. P. Singer. "Age-Related Changes in Collagen, Pyridinoline, and Deoxypyridinoline in Normal Human Thoracic Intervertebral Discs." Journals of Gerontology Series A: Biological Sciences and Medical Sciences 58, no. 5 (May 1, 2003): B387—B393. http://dx.doi.org/10.1093/gerona/58.5.b387.

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Kabak, S. L., V. V. Zatochnaya, and N. O. Zhizhko-Mikhasevich. "X-ray genetic phenotype of congenital disease development." Proceedings of the National Academy of Sciences of Belarus, Medical series 15, no. 4 (January 14, 2019): 414–21. http://dx.doi.org/10.29235/1814-6023-2018-15-4-414-421.

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The aim of the study is to describe the radiological phenotype of vertebral malformations in congenital scoliosis and to discuss the possible mechanisms of morphogenesis of some of these anomalies. The article describes 5 cases of complete or partial splitting in the sagittal plane of the body of one of the thoracic vertebrae (butterfly-shaped vertebra). The anterior vertebral cleft was combined with other congenital vertebral anomalies: block of vertebra, hemivertebrae, spina bifida posterior. All patients had scoliosis with right-sided or left-sided curves. In the human fetuses of the first trimester of gestation without visible malformations in the cartilaginous anlages of the thoracic vertebral bodies we revealed the presence of one o three centers of ossification, and in the fetus with exensephaly – the lack of the intervertebral disc anlage between the bodies C2-C3. According to the published data, the etiology of congenital vertebral anomalies is multifactorial. In the pathogenesis of this pathology, there is a violation of local blood flow due to the anomalous course of intersegmental arteries and as a consequence – a complete or partial separation of adjacent somites or associated mesenchyme. According to the published data, a possible cause of the anterior cleft may be untimely an involution of cartilage canals, the growth of which in the cartilaginous anlage of the vertebral body precedes the appearance of the ossification center. The absence of the intervertebral disk at a considerable length between the cartilaginous anlages of bodies 2 and 3 of the cervical vertebrae in the human fetus with exencephaly indicates a close relationship between the axial skeleton and the neural tube.
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Kunkel, Maria E., Andrea Herkommer, Michael Reinehr, Tobias M. Böckers, and Hans-Joachim Wilke. "Morphometric analysis of the relationships between intervertebral disc and vertebral body heights: an anatomical and radiographic study of the human thoracic spine." Journal of Anatomy 219, no. 3 (May 25, 2011): 375–87. http://dx.doi.org/10.1111/j.1469-7580.2011.01397.x.

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Weiler, C., M. Schietzsch, T. Kirchner, A. G. Nerlich, N. Boos, and K. Wuertz. "Age-related changes in human cervical, thoracal and lumbar intervertebral disc exhibit a strong intra-individual correlation." European Spine Journal 21, S6 (August 12, 2011): 810–18. http://dx.doi.org/10.1007/s00586-011-1922-3.

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Lohse, C. L., D. M. Hyde, and D. R. Benson. "Comparative Development of Thoracic Intervertebral Discs and Intra-Articular Ligaments in the Human, Monkey, Mouse, and Cat." Cells Tissues Organs 122, no. 4 (1985): 220–28. http://dx.doi.org/10.1159/000146019.

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Dissertations / Theses on the topic "Human thoracic intervertebral disc"

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Tan, Celia I. C. "A radiological and biochemical perspective on ageing and degeneration of the human thoracic intervertebral disc." University of Western Australia. School of Surgery and Pathology, 2004. http://theses.library.uwa.edu.au/adt-WU2004.0059.

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Disc degenerative changes are directly or indirectly associated with spinal pain and disability. Literature revealed a high prevalence of disc degeneration in the thoracic region, however thoracic MRI degeneration trends and information on disc biochemical matrix constituents are limited for thoracic discs compared to lumbar and cervical discs. The objective of this thesis was to use MRI to investigate the prevalence of disc degenerative changes affecting the human thoracic spine, and to determine the factors affecting spinal disc biochemical matrix. A 3-point subjective MRI grading scale was used to grade the films. The feasibility of using archived formalin-fixed cadaver material was investigated to analyse collagen and elastin crosslinks. The prevalence of degenerative changes in human thoracic discs and vertebrae (T1 to T12) was determined retrospectively from an audit of 216 MRI cases, using sagittal T1- and T2-weighted MR images. In a subsequent series of ex-vivo studies, human thoracic discs and LF from 26 formalin-fixed and two fresh spines, involving all thoracic levels, were examined macroscopically to determine the degeneration status. Subsequently, disc and ligament tissues were analysed biochemically for collagen (pyridinoline and deoxypyridinoline) and elastin (desmosine and isodesmosine) crosslinks. These crosslinks were extracted from hydrolysed samples by cellulose partition chromatography, and analysed by reverse-phase HPLC. Collagen content was determined using its hydroxyproline content, and proteoglycan content was assayed using a modified DMB assay for chondroitin sulphate. Finally the MRI and macroscopic assessments of thoracic discs, were compared with the biochemical data from two fresh cadaver thoracic spines. The 3-point MRI grading scale had a high inter- (k = 0.57 to 0.78) and intra-rater (k = 0.71 to 0.87) reliability. There were no significant differences in the collagen and elastin content and extent of collagen crosslinks between formalin fixed and unfixed ligament and disc tissues, after 25 weeks of formalin fixation. From the in-vivo MRI series of investigations (n = 216 MRI films), the prevalence of thoracic disc degenerative and vertebral morphological changes revealed significant age, gender and spinal level trends (p < 0.05).Generally, males had a higher propensity for disc degeneration in contrast to females, especially older females, where the trend showed a higher prevalence of osteophytes and vertebral body changes. In particular, the mid and lower thoracic levels have a higher prevalence of degenerative changes, except for osteophytes and anterior vertebral wedging. With increased age, there was a concomitant increase in anterior wedging and bi-concavity and disc degenerative changes except for end-plates. The biochemical investigations on the ex-vivo series of formalin-fixed thoracic discs (n = 303) also revealed significant changes in the disc matrix due to degeneration status, age, gender and spinal regional factors. With increased age, normal disc matrices have significantly lower collagen content and extent of pyridinoline (p < 0.001). In contrast, the degenerated disc matrix revealed significantly higher collagen content and extent of deoxypyridinoline (p < 0.05). These findings suggest that an altered matrix existed in normal ageing discs, which render the disc prone to injury and degeneration over the life span. The higher collagen and deoxypyridinoline in degenerated disc matrices reflects an increase in chondrocyte synthesis, and is also a novel finding, suggesting that they may be used as markers of ageing and degeneration processes. The biochemical investigations on another series of ex-vivo spinal LF tissues (n = 364), revealed that this had a lower collagen and pyridinoline, but significantly higher elastin and deoxypyridinoline compared to spinal discs (p < 0.05). Elastin crosslinks however were difficult to detect in spinal discs, being present in negligible amounts in a few lumbar discs. The elastin crosslinks in the LF were not significantly affected by age, but were significantly higher in calcified, and female ligamentum tissues, and also in the lumbar region (p < 0.05). These MRI prevalence findings enhanced our knowledge of vertebral body and disc degeneration trends in the thoracic region and contributed to the interpretation of MR images for pathology in the human thoracic spine. Information on the associated collagenous and elastic changes in the disc and ligamentum matrices provide original data and insight on the pathogenesis of degeneration in the disc matrix from a biochemical perspective, highlighting gender, age and spinal level influences on the matrix tensile strength and cellular synthetic activities.
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Liu, Jane J. "Proteoglycans of the human intervertebral disc." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68204.

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The composition and heterogeneity of human intervertebral disc proteoglycans from different aged individuals were investigated. (1) The glycosaminoglycan content in the nucleus pulposus was greater than that in the annulus fibrosus at all ages. Glycosaminoglycan content increased from the infant to the young adult, and then decreased from the young to the mature adult. (2) Disc contained a higher content of hyaluronate than articular cartilage at all ages. (3) Proteolytically modified LP3 was predominant in the disc. (4) Very low link protein concentrations were observed in adult disc proteoglycan preparations and adult disc extracts analysed by SDS/PAGE and immunoblotting suggesting a deficiency in link protein content. In contrast, radioimmunoassay of disc extracts suggests no deficiency in link protein content. (5) The existence of extremely fragmented link protein in adult disc is postulated to reconcile the results of the two analytic methods. (6) Non-proteoglycan forms of biglycan and decorin are present in the disc. The difference between the two non-proteoglycan forms of biglycan appears to be due to different N-linked oligosaccharide substitution rather than proteolysis.
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Pockert, Aneta Joanna. "Aggrecanolytic ADAMTS Expression in Human Intervertebral Disc Degeneration." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492880.

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Low Back Pain (LBP) affects 60-80% of the population at some point in their lives with approximately 10% of sufferers being chronically disabled. Degeneration of the intervertebral disc (DIVD) has been identified as one of the main causes of LBP.
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Antoniou, John. "Quantitative biochemical changes in the human lumbar intervertebral disc." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0028/NQ50103.pdf.

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Frain, Jennie. "The effects of mechanical load on human intervertebral disc cells." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493463.

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The precise mechanisms by which human intervertebral discs (IVD) respond to load remains unknown and are a challenge to investigate in vitro. In this study, a novel mechanical loading system was devised, built, tested and successfully used to apply hydrostatic pressure to nucleus pulposus (NP) and annulus fibrosis (AF) cells and explants obtained from human nondegenerate and degenerate IVD. Cells were removed from the IVD, cultured in monolayer to generate sufficient numbers and subsequently embedded in alginate constructs prior to application of dynamic cyclic hydrostatic pressure at physiological levels.
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Chak-Sum, S. Ng. "The connective tissue degrading enzyme system of the human intervertebral disc." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376277.

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Montanari, Sara. "The effect of intervertebral disc simulated damage on the human spine biomechanics." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/19926/.

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More than 50% of intervertebral discs in the third and fourth decade of life exhibit annular tears and fissures with different orientations and extents. On the other hand, in vitro biomechanical investigations of the disc surgery treatment, sometimes requires collaterals lesions, such as incision or disc material removal to recreate biological injuries, as in discoplastly. These lesions could have a mechanical impact on the spine flexibility and in the surrounding tissue and could alter the final outcomes of in vitro studies. The influence of the presence of lesions on the biomechanics of the segment is still a debated research question. Thus, this in vitro study aims to evaluate changes in spine biomechanics, in terms of stiffness, range of motion and disc height, induced by an increasing damage of human disc. In order to assess the impact of the annulus damage on the surrounding tissues, principal strain distributions were investigated in the lateral side opposite than the damaged region. Eight fresh cadaver thoraco-lumbar FSUs were used in this study. The specimens were tested sequentially in flexion and extension in five different configurations: a) with the intact disc; b) with two vertical cuts; c) with four cuts, forming a square, without removing any part of the annulus; d) after having removed the cut part of the AF; e) after having removed the nucleus pulposus. Image analysis and surface strain distribution were performed on the lateral disc by means of the Digital Image Correlation.
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Parry, Joanna. "The comparison of different pathologies of the annulus fibrosus in human intervertebral disc." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342052.

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Lakstins, Katherine S. "Investigating the human cartilage endplate in chronic low back pain: from mechanisms of degeneration to molecular, cell and tissue level characterization." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1584627459584403.

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Stolworthy, Dean K. "Advancing Biomechanical Research Through a Camelid Model of the Human Lumbar Spine." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5590.

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The increasing incidence of disc degeneration and its correlation with lower back pain is an alarming trend in modern society. The research of intervertebral disc degeneration and low back pain would greatly benefit from additional methods to study its etiology and possible treatment methods. A large animal model that maintains the biological and mechanical environment that is most similar to the human lumbar spine could provide substantial improvements in understanding and resolving the problem of intervertebral disc related low back pain.This dissertation presents my doctoral work of investigating the potential for the camelid cervical spine to serve as a suitable animal model for advancing biomechanical research of low back pain and intervertebral disc degeneration in the human lumbar spine. Specifically, this work identifies the cellular, morphological and biomechanical characteristics of the camelid cervical spine and intervertebral disc as compared to the human lumbar spine. My results demonstrate that there are remarkable similarities in all aspects. Many of the similarities with respect to the cellular environment of the intervertebral disc are a consequence of the camelid status as a large mammal. Additional testing of the cellular makeup of the camelid intervertebral disc cells revealed that many human qRT-PCR primers associated with disc degeneration are suitable for use in alpacas without modification. From a biomechanics standpoint, the camelid cervical spine also has a vertically oriented spinal posture and is unsupported near the end in an open kinetic chain, providing a mechanical parallel with the human lumbar spine. The camelid cervical intervertebral disc size is closer to the human lumbar intervertebral disc than all other currently used animal models available for comparison in the literature. Average flexibility (range of motion) of a camelid spinal motion segment showed similarities in all modes of loading. Based on magnetic resonance imaging and radiologic grading of the intervertebral disc, almost 90% of elderly camelids exhibited advanced degeneration (Pfirrmann grade 3 or higher) in their cervical spine, and about half of aged camelids have developed severe degeneration (Pfirrmann grade 4 or higher) in at least one or more of their cervical segments, most commonly within the two lowest cervical segments (e.g. c6c7 and/or c7t1). Thus, while there remain differences, the remarkable similarities between the camelid and human spine strengthen the case for using camelids as a model for human disc degeneration, normal and pathological biomechanics and fluid transport, and potentially as a pre-clinical model for investigating the efficacy of novel spinal devices.
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Books on the topic "Human thoracic intervertebral disc"

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Hadley, Graham R., Matthew Novitch, Mark R. Jones, Vwaire Orhurhu, Alan D. Kaye, and Sudhir A. Diwan. Comprehensive Review of Discography in Spinal Pain. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190626761.003.0014.

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Neck and back pain are common in the adult population, with many adults experiencing such pain at any one point in time. Both are a common cause of disability and socioeconomic burden, with relatively high annual prevalence rates. The aim of discography involves determination of the morphology of the nucleus pulposus and annulus fibrosus of the intervertebral disc. The knowledge of structural integrity of the disc is the fundamental principle in determining whether the neck or back pain is discogenic in nature. This chapter discusses the safety profile and diagnostic utility of discography, as well as the controversy that still remains over its clinical use, with respect to the cervical, thoracic, and lumbar spine regions.
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Book chapters on the topic "Human thoracic intervertebral disc"

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Wieslander, S., J. Praestholm, H. Videbæk, V. Hennild, O. Osgaard, and O. Henriksen. "Thoracic intervertebral disc herniation: diagnostic value of MRI and CT." In Proceedings of the XIV Symposium Neuroradiologicum, 347–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-49329-4_119.

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Glinkowski, W., E. Łukowiak, and M. Brzozowska. "Optical Properties of the Human Lumbar Intervertebral Disc." In Lasers in the Musculoskeletal System, 244–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56420-8_37.

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Bergknut, Niklas, Franck Forterre, Jonathan M. Levine, Steven D. Lasser, and James M. Fingeroth. "Comparisons between Biped (Human) and Quadruped (Canine/Feline) Intervertebral Disc Disease." In Advances in Intervertebral Disc Disease in Dogs and Cats, 14–22. Chichester, UK: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118940372.ch3.

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Snijders, H., J. Huyghe, P. Willems, M. Drost, J. Janseen, and A. Huson. "A Mixture Approach to the Mechanics of the Human Intervertebral Disc." In Mechanics of Swelling, 545–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-84619-9_31.

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Snijders, H., J. Huyghe, C. Oomens, M. Drost, and J. Janssen. "A Mixture Approach to the Mechanics of the Human Intervertebral Disc." In Integration of Theory and Applications in Applied Mechanics, 65–71. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-2125-2_6.

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Jaffee, Stephen, Isaac Swink, Brett Phillips, Michele Birgelen, Alexander Yu, Nick Giannoukakis, Boyle Cheng, et al. "Mechanobiology of the Intervertebral Disc and Treatments Working in Conjunction with the Human Anatomy." In Handbook of Spine Technology, 1–18. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-33037-2_22-1.

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Jaffee, Stephen, Isaac R. Swink, Brett Phillips, Michele Birgelen, Alexander K. Yu, Nick Giannoukakis, Boyle C. Cheng, et al. "Mechanobiology of the Intervertebral Disc and Treatments Working in Conjunction with the Human Anatomy." In Handbook of Spine Technology, 275–91. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-44424-6_22.

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Balamurugan, S., P. Susai Manickam, and Sachit Chawla. "Lumbar Discography: Study of Biomechanical Changes in the L1-L2 Intervertebral Disc of the Human Lumbar Spine Using Finite Element Methods." In Lecture Notes in Mechanical Engineering, 623–33. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-4488-0_52.

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Lostado Lorza, Rubén, Fátima Somovilla Gomez, Roberto Fernandez Martinez, Ruben Escribano Garcia, and Marina Corral Bobadilla. "Improvement in the Process of Designing a New Artificial Human Intervertebral Lumbar Disc Combining Soft Computing Techniques and the Finite Element Method." In International Joint Conference SOCO’16-CISIS’16-ICEUTE’16, 223–32. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-47364-2_22.

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"Thoracic Intervertebral Disc Herniation." In Imaging in Neurology, 361. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-323-44781-2.50278-3.

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Conference papers on the topic "Human thoracic intervertebral disc"

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Truman, Mari S., Lisa A. Ferrara, Ryan Milks, Illya Gordon, and Jason Eckhardt. "Acute Thoracic Vertebral Injury Thresholds." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-62178.

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This study measures select static and dynamic characteristics of the human mid-thoracic spine, and compares them to previously published data for the thoraco-lumbar and cervical regions. Little information is available on the acute injury threshold for mid-thoracic intervertebral discs. The aim of this study was to characterize injury thresholds for the thoracic spine. Non-destructive combined flexion-compression loading experiments were conducted on 5 fresh human T5-T10 functional spinal units (FSU) at quasi-static and physiologic strain rates, and the resulting load-deflection responses were converted into global and local stiffness. Subsequently, 29 thoracic vertebrae (T5-T10) from 6 spines were subjected to moderate to severe impact loading in flexion. The peak forces and pressures were not statistically different between the thoracic disc levels. However, the mean injury forces and pressures were statistically different from mean failure forces found in the literature for both the lumbar and cervical spine regions, with the thoracic values falling between the cervical and lumbar values.
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2

Stemper, Brian D., Narayan Yoganandan, and Frank A. Pintar. "Effects of Thoracic Ramping on Whiplash Kinematics." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-59447.

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Whiplash injuries result from differential motion between the head and thorax. Experimental investigations using human volunteers and full body cadavers have described thoracic ramping due to interaction with the seatback and straightening of the thoracic spine. The effect of this motion on cervical kinematics has not been investigated. A head-neck computer model was used to determine the effects of thoracic ramping on whiplash kinematics. The model consisted of skull, cervical spine, first thoracic vertebra, intervertebral discs, spinal ligaments, facet joints, and passive musculature, and was subjected to 2.7 m/sec rear impact velocity. Vertical acceleration of T1 was prescribed according to literature. Segmental angulations and region dependent facet joint capsular ligament distractions were obtained from levels C2-C3 through C7-T1 during the time of cervical S-curvature. Maximum capsular ligament distractions during this time occurred in the dorsal region at the C2-C3 level and in the lateral region at the C3-C4 through C7-T1 levels. Increasing magnitudes of T1 ramping decreased segmental angulations and ligament distractions by less than 20% in most cases. Results of the present investigation demonstrated that thoracic ramping may play a secondary role in whiplash kinematics.
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3

Jackson, Alicia R., Tai-Yi Yuan, Chun-Yuh Huang, and Wei Yong Gu. "Mechanical Compression Affects Nutritional Transport in Human Intervertebral Disc." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19262.

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Although the exact cause is not clear, low back pain has been attributed to degeneration of the intervertebral disc (IVD) of the spine, which has been linked to poor nutritional supply to the disc. Because the IVD is the largest avascular structure in the human body, disc cells must rely on diffusional transport for delivery of important nutrients, such as oxygen and glucose, from the surrounding vasculature. Thus, understanding factors affecting nutritional supply to the cells is important in elucidating the etiology of disc degeneration and related back pain. While knowledge of how mechanical strain affects nutritional transport is important in understanding these phenomena, little can be found in the literature regarding strain-dependent diffusion of nutrients in human IVD.
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4

Ranu, Harcharan Singh, Aman Sweet Bhullar, and Abdulrahim Zakaria. "Viscoelastic Behaviour of the Human Spinal Disc." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-38036.

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An intradiscal pressure transducer (IDPT) and a set of intervertebral pressure transducer (IVPT) were developed to measure the pressures in the nucleus pulposus and around the annulus. Human lumbar spinal segments were loaded up to 2.0 kN and following parameters were recorded: applied compressive load as a function of time, intradiscal pressure as a function of time, intervertebral pressure as a function of time for anterior and lateral edges of the vertebra, strain as a function of time for anterior and lateral right and left sites of the vertebra, stress-relaxation of the complete segment as a function of time. All show very similar response to loading and stress-relaxation. However, annulus pressure did not respond to stress-relaxation. This was due to functional aspect of annulus.
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5

Yao, Hai, and Wei Yong Gu. "Multiphasic Mechano-Electrochemical Finite Element Model of Human Intervertebral Disc." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176511.

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The intervertebral disc (IVD) is the largest cartilaginous structure in human body that contributes to flexibility and load support in the spine. To accomplish these functions, the disc has a unique architecture consisting of a centrally-located nucleus pulposus (NP) surrounded superiorly and inferiorly by cartilage endplates and peripherally by the annulus fibrosus (AF). Because the disc is avascular and experiences mechanical loads, the cells in IVD tissues live in a complex physical environment. Knowledge of mechanical, chemical and electrical signals within the tissue is important for understanding mechanobiology of IVD [1]. The objective of this study was to develop a three-dimensional (3D), inhomogeneous finite element model (FEM) for human IVD for analyzing the physical environment and solute transport within the tissue under different mechanical loading conditions. A case of IVD under axial compression was simulated and reported.
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6

Natarajan, Raghu N., Alejandro Espinoza, and Gunnar B. J. Andersson. "Effect of Needle Puncture Injury on Human Intervertebral Disc Mechanics." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19116.

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Diagnosis, repair and regeneration of the disc often necessitate needle injection to the nucleus pulposus through the annulus. Discography in which a radio opaque material is injected into the nucleus and electrothermal treatment involving inserting a catheter into the disc requires disruption of the annulus through needle puncture. Annulus puncture may also be required during placement of nucleus implants. Needle puncture is also used to inject growth factors, gene and cell therapy for regeneration of the disc. In animal models, disc degeneration is induced over time by needle puncture of the annulus. The severity of the degeneration depends on the magnitude of the annulus needle puncture. One thing that is not clear is how much of the observed changes in the disc biomechanics and biochemical changes are due to nucleus treatment and how much is due to annular disruption through needle puncture. Animal model studies have shown that significant changes in disc mechanics were noticed within 1 week of needle puncture with a large-gauge needle. Another in-vitro animal study showed that biomechanical changes were observed in the disc when the ratio of needle diameter to disc height is greater than 40%. All these studies were focused on the effect of small number of needle diameters and addressed using animal cadaver models. How these needle puncture injury studies on small and large animal models can be extrapolated to human conditions is still not known. Thus there is need to evaluate effect of range of needle puncture diameters in human lumbar disc biomechanics. The purpose of this study is, with the help of a finite element models, quantify the biomechanical effect due to varying size of needle punctures in a human lumbar intervertebral disc.
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7

Jamison, David, and Michele Marcolongo. "The Effect of Creep on Human Lumbar Intervertebral Disc Impact Mechanics." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14176.

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The intervertebral disc (IVD) is often modeled as a biphasic tissue, with both a solid and a fluid phase [1]. While under a constant compressive load, the IVD responds with continuous creep displacement, resulting in the loss of interstitial fluid from the tissue and increased strain on the annular fibers. The mechanical response of the IVD under impact loading conditions has been previously reported by the authors and others. It is unknown, however, how the loss of interstitial fluid affects disc biomechanics under impact loads. In this study, we investigate the effects of creep on IVD impact mechanics.
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8

Mistri, Gayatri K., and Kamlesh J. Suthar. "FEM of Coupled Chemo-Electro-Mechanical Behavior of Human Intervertebral Disc." In ASME 2013 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/smasis2013-3226.

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This paper describes a fully coupled finite element simulation of the chemo-electro-mechanical effect of the swelling characteristic of a human intervertebral disc. The swelling behavior of human intervertebral disc is strongly influenced by various environmental stimuli such as concentration of the mobile ions, fixed charges on fibrous material, and pH of the surrounding bio-fluid. The swelling behavior can be described by three physical partial differential equations. These equations are-Nernst-Plank for chemical species transport, Poisson’s for the balanced fixed charges inside the vertebral disc, and mechanical field for balanced osmotic pressure and resulting expansion of the disc. The converged solution of the 2D finite element simulation was achieved by full coupling among these equations in moving mesh domain. The effects of several important physical conditions, such as concentration of mobile ions, pH change in surrounding bio-fluid, electrical charge balance, and the expansion/shrinkage of vertebral disc are simulated. The simulation results are discussed in detail.
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9

Han, Hyun Kyu, Jenni M. Buckley, Kathy Kursa, Conor O’Neill, and Jeffrey C. Lotz. "Microdialysis Technique for Quantifying Drug Concentration in Human Intervertebral Discs." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206176.

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New diagnostic and treatment techniques for chronic lower back pain involve localized drug delivery into the lumbar intervertebral disc [1,2]. A better understanding of these new techniques could be gained by measuring drug concentration at specific intradiscal locations at different time points [1]. Currently, there are no established methods for quantifying real-time in situ drug concentrations in the human intervertebral disc; however, injection profiles have been successfully characterized in pig disc, human brain, adipose tissue, and blood using microdialysis [3,4,5]. This technique involves continuous sampling of interstitial fluid via semi-permeable membranes mounted on miniature, implantable catheters [6]. Given the success of microdialysis in characterizing the real-time composition of other poroelastic tissues, we hypothesize that this method will be similarly successful when applied to human lumbar disc.
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10

Liu, Xiaoyun, Xinghuo Wu, Liu Hui, Weihua Xu, Xianze Liu, and Shuhua Yang. "Morphologic characteristics of processes of nucleus pulposus cells in adult human intervertebral disc." In Photonics and Optoelectronics Meetings, edited by Qingming Luo, Lihong V. Wang, and Valery V. Tuchin. SPIE, 2008. http://dx.doi.org/10.1117/12.823399.

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