Academic literature on the topic 'Human population history of Indians'
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Journal articles on the topic "Human population history of Indians"
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Goicoechea, Alicia S., Francisco R. Carnese, Alicia L. Caratini, Sergio Avena, Maria Salaberry, and Francisco M. Salzano. "Demography, genetic diversity, and population relationships among Argentinean Mapuche Indians." Genetics and Molecular Biology 23, no. 3 (September 2000): 513–18. http://dx.doi.org/10.1590/s1415-47572000000300001.
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Fertility, mortality and migration data from four Mapuche Indian communities located along a 215-km NE-SW linear area in the Province of Río Negro, Argentina, were collated with genetic information furnished by nine blood group systems and by mtDNA haplogroups. The demographic and genetic data indicated a clear dichotomy, which split the four populations into two groups of two. Differing degrees of non-Indian exchanges was probably the main determining factor for this separation. Total genetic variability was very similar in all groups, and the interpopulational variability accounted for only 10% of the total variability. A low prevalence of the Diego(a) antigen among the Mapuche was confirmed. The fact that significant genetic heterogeneity and population clusters were found in such a small territorial region attests to the sensitivity of demographic and genetic approaches in unraveling human history.
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Martinez-Serna, Gabriel. "Jesuit Missionaries, Indian Polities, and Environmental Transformation in the Lagoon March of Northeastern New Spain." Journal of Early American History 3, no. 2-3 (2013): 207–34. http://dx.doi.org/10.1163/18770703-00303008.
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The introduction of European agriculture and livestock transformed the natural and human landscape of the Americas profoundly. In the borderlands of the continent, it was often missionaries who introduced these practices to areas where mobile Indians groups had adapted their cultures to an environment that was irrevocably changed. Transforming a landscape usually doomed a mobile ethnic group to forced adaptation, migration or extinction, but could also prove a catalyst to an ethnogenesis that could not have occurred without the effects the Columbian Exchange brought about by the missionaries. The so-called Lagoon March (Comarca Lagunera) of the northeastern borderlands of New Spain experienced perhaps the most dramatic of these episodes in this story of Colonial North America. This region was home to the Lagunero Indians, the most populous pre-contact group in the borderlands, and as late as the last decade of the sixteenth century it was a lush lagoon environment surrounded by wooded mountains. The Jesuits founded the Parras mission there in 1598, and within two generations, the Laguneros had largely disappeared, and the area was transformed into an archipelago of highly productive oasis surrounded by scrub barely suitable for livestock. Viticulture made the area the richest non-mining region of the entire frontier, and a magnet for population. Tlaxcalan (Nahua) colonist that had lived in the mission and survived the Lagunero extinction became a borderlands community intrinsically attached to viticulture and communal rights to water from the region’s only major spring, giving them a legal status that distinguished them from other Indian groups (including other Tlaxcalans) and underlining a social cohesion that lasted until the Independence period. Thus, the unintended effects of the Jesuit presence transformed the Parras environment and the way Indian identity related to it.
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Jones, Alick R. "Dietary Change and Human Population at Indian Creek, Antigua." American Antiquity 50, no. 3 (July 1985): 518–36. http://dx.doi.org/10.2307/280319.
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The midden at Indian Creek, Antigua, is very probably a nearly complete record of the animal food consumed by the inhabitants over about 1,100 years of occupation. During that time the resource exploitation pattern changed in a number of major and minor ways. The most obvious change, when crab gave way to bivalve mollusks as an important dietary element, has been examined in some detail and the possible causes for the change discussed. Although the data presented here could be used for a variety of theoretical models it seems likely that no single model is sufficient to explain all the changes. The faunal remains obtained from the excavation have been used to calculate the amount of protein represented and this in turn used to calculate the approximate mean human population over the period of occupation. The figure obtained is between 21-53 depending upon the criteria adopted. The possible sources of error in the calculations are identified and discussed.
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Rahman, Gazi Mizanur. "Transnational History and Colonial Records: Locating Bengali Mobility in the British Malaya." Journal of Maritime Studies and National Integration 3, no. 2 (December 9, 2019): 97. http://dx.doi.org/10.14710/jmsni.v3i2.6267.
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By the late 1980s, some historians began to identify their works as transnational history – which dealt with the past human mobility, and the circulation of goods, information, and ideas across the globe. Colonial records are an essential source for reconstructing transnational history. However, some of the colonial census-makers were not aware of the racial identity of transmigrants during the population enumeration. They categorised the transmigrants under different umbrella heads, and due to their stringent systems of cataloguing, the identity of diverse migrants was misplaced or generalised in census reports. Therefore, these certain ambiguities complicate the reconstruction of the transnational history of some specific migrant communities. With the impact of British colonialism in present-day South and Southeast Asia, South Asian multi-ethnic people, including Bengalis, migrated to Malaya. Initially, the British colonial administrators categorised the South Asian multi-racial migrants under different heads including “Bengalis & c.”, “Tamils & c.” and “Indians”. These umbrella terms in colonial records create problems in reconstructing the transnational history of anyone specific race from South Asia, such as the Bengali. Through a reinterpretation of colonial documents, empirical evidence, and oral interviews, this paper attempts to locate the Bengali migrants in British Malaya.
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Sommer, Barbara A. "Colony of the Sertão: Amazonian Expeditions and the Indian Slave Trade." Americas 61, no. 3 (January 2005): 401–28. http://dx.doi.org/10.1353/tam.2005.0053.
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After expelling their European rivals from the Amazon in the early–seventeenth century, the Portuguese set about exploiting the principal assets of the vast basin—the indigenous inhabitants. As allies, converts, and slaves the native population provided the labor and much of the social fabric of the developing colony. While a variety of canoe-borne expeditions ventured ever farther up the main river and its tributaries seeking elusive gold, harvesting forest products, and expanding the crown's domain, prosperity and power for the leaders and sponsors of those forays derived mainly from the human cargo brought downstream to missions, forts, and other settlements. As a result, crown and colonial authorities attempted to regulate and control the expeditions, and fierce competition developed among institutions and individuals involved in the process. Documents in Portuguese and Brazilian archives reveal the key role played by the Indians themselves in collaboration with the little-studied cross-cultural intermediaries, known as cunhamenas.
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Pande, S., and M. Ertsen. "Endogenous change: on cooperation and water in ancient history." Hydrology and Earth System Sciences Discussions 10, no. 4 (April 17, 2013): 4829–68. http://dx.doi.org/10.5194/hessd-10-4829-2013.
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Abstract. We propose and test the theory of endogenous change based on historical reconstructions of two ancient civilizations, Indus and Hohokam, in two water scarce basins, the Indus basin in the Indian subcontinent and the Lower Colorado basin in Southwestern United States. The endogenous institutional change sees changes in institutions as a sequence of equilibria brought about by changes in "quasi-parameters" such as rainfall, population density, soil and land use induced water resource availability. In the historical reconstructions of ancient civilizations, institutions are proximated by the scale of cooperation be it in the form of the extent of trade, sophisticated irrigation network, a centrally planned state or a loosely held state with a common cultural identity. The "quasi-parameters" either change naturally or are changed by humans and the changes affect the stability of cooperative structures over time. However, human influenced changes in the quasi-parameters itself are conditioned on the scale of existing cooperative structures. We thus provide insights into the quantitative dimensions of water access by ancient populations and its co-evolution with the socioeconomic and sociopolitical organization of the human past. We however do not suggest that water manipulation was the single most significant factor in stimulating social development and complexity – clearly this has been shown as highly reductionist, even misleading. The paper cautiously contributes to proximate prediction of hydrological change by attempting to understand the complexity of coupled human-hydrological systems.
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Stannard, David E. "Disease and Infertility: a New Look at the Demographic Collapse of Native Populations in the Wake of Western Contact." Journal of American Studies 24, no. 3 (December 1990): 325–50. http://dx.doi.org/10.1017/s0021875800033661.
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During the past fifty years few subjects of historical consequence have been more controversial than that of the population history of the American Indian. At one extreme, in 1939 Alfred L. Kroeber estimated the population of pre-Columbian North America at about 900,000. At the other extreme, in 1983 Henry F. Dobyns estimated it at about 18,000,000. Since the total North American Indian population by the early twentieth century was no more than 350,000 to 450,000, the human question concealed in the statistical controversy is staggering: did the North American Indian population decline by a ratio of about 2 to 1 between the end of the fifteenth century and the end of the nineteenth century – or did it decline by 50 to 1 ? Or more?
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Bahl, Ankur, Lalit Dar, BK Mohanti, Pankaj Kumar, Alok Thakar, Venkat Karthikeyan, and Atul Sharma. "Prevalence, trends, and survival impact of human papillomavirus on oropharyngeal cancer in Indian population." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 5540. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.5540.
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5540 Background: Among oropharyngeal squamous cell carcinoma (OSCC), the true prevalence of HPV remains variable and studies have estimated that up to 60% may be HPV positive. Patients with HPV positive tumor are usuallyyounger in age, less likely to have history of tobacco or alcohol consumption and associated with a better prognosis but this information for Indian patients is largely unknown. Methods: 105 newly diagnosed patients of OSCC were enrolled. HPV genotyping was done on the biopsy specimen by consensus polymerase chain reaction and reverse line-blot hybridization assay. HPV prevalence was studied according to gender, age, tobacco and alcohol use and high risk sexual behavior. Results: Overall HPV prevalence was 22.8%. HPV positive patients were younger by 8 years as compared to negative patients (P=0.003). No significant correlation between tobacco consumption, alcoholic habits, and HPV status was observed. The mean number of life time sexual partners in HPV positive patients was 1.66 while, it was 1.33 in HPV negative patients (P=0.049). Incidence of high risk sexual behaviors was more in HPV positive patients (P<0.001). There were no significant associations between the two groups with respect to tumor size, nodal stage and the overall stage of the tumor. 16% of the base of tongue cancers and 40% of tonsillar carcinoma were positive (P = 0.02). Among positive samples, HPV 16 was the commonest (79%) followed by HPV 18 (12%). 96% of patients received treatment. At 18.8 months there was no significant difference in OS, EFS between HPV positive and negative OSCC (P = 0.97 and P= 0.51 respectively). Conclusions: The current study reconfirms that HPV positive OSCC patients are younger with high risk sexual behavior. Impact of smoking and alcohol consumption on HPV status was not found in this study. HPV positive rates were significantly higher for tonsillar cancer. Contrary to literature, we did not find any differences in OS or EFS between two groups. Small numbers of patients in the study group, short follow up period and significant tobacco smoking in HPV group may be the one of the reason for this.
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Haring, Lee. "Eastward to the Islands: The Other Diaspora." Journal of American Folklore 118, no. 469 (July 1, 2005): 290–307. http://dx.doi.org/10.2307/4137915.
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Abstract The Indian Ocean islands of Mauritius, Réunion, and Seychelles, named the "Mascareignes" after a Portuguese explorer, are products of an eastward African diaspora, almost invisible in the West except to a few historians. Empty of human population until European exploitation settled them with afew colonists and thousands of slaves from East Africa and Madagascar, their multicultural history demonstrates the astonishing durability of African and Malagasy cultures. Folktales provide the finest window into that history and its values. Through that window, creolization is revealed in its actual occurrence.
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Sharma, Shivam. "Partition of India: The Gurdaspur Dispute." Journal of University of Shanghai for Science and Technology 23, no. 07 (July 27, 2021): 1270–78. http://dx.doi.org/10.51201/jusst/21/07271.
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The Partition of India was arguably one of the largest Two-way migration in human history. There are several sets of census data and other verified sources which strengthens the argument that the exchange of population since 1947 has caused immense harm to the integrity of the Indian Sub-continent which is beyond repair. The paper discusses a brief history and the sequence of events that lead to the allotment of three out of four tehsil’s of Gurdaspur district to the Indian dominion despite having a majority Muslim population. The importance of Gurdaspur was remarkable for both the dominions and the contested area was earlier assumed to be allotted to Pakistan while a later amendment made it a part of India, which opened routes for a direct pathway to Kashmir. It also discusses the Radcliffe Commission that was appointed to demarcate the two new separate dominions, India, and Pakistan in just eight weeks.
Dissertations / Theses on the topic "Human population history of Indians"
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Klaus, Haagen D. "Out of Light Came Darkness: Bioarchaeology of Mortuary Ritual, Health, and Ethnogenesis in the Lambayeque Valley Complex, North Coast Peru (AD 900-1750)." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1209498934.
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Warrick, Gary A. "A population history of the Huron-Petun, A.D. 900-1650." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39238.
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This study presents a population history of the Huron-Petun, Iroquoian-speaking agriculturalists who occupied south-central Ontario from A.D. 900 to A.D. 1650. Temporal change in the number, size, and residential density of prehistoric and contact village sites of the Huron-Petun are used to delineate population change. It is revealed that Huron-Petun population grew dramatically during the fourteenth century, attaining a maximum size of approximately 30,000 in the middle of the fifteenth century. This growth appears to have been intrinsic (1.2% per annum) and is best explained by colonization of new lands and increased production and consumption of corn. Population stabilized during the fifteenth century primarily because of an increased burden of density-dependent diseases (tuberculosis) arising from life in large nucleated villages. Huron-Petun population remained at 30,000 until A.D. 1634; there is no archaeological evidence for protohistoric epidemics of European origin. The historic depopulation of the Huron-Petun country, resulting from catastrophic first encounters with European diseases between 1634 and 1640, is substantiated by archaeological data.
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Wilson, James F. "Human population structure and demographic history using genetic markers." Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:5a4844ff-9347-44b5-999e-64ce5025006f.
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The evolutionary history of the human species has generated complex patterns of population structure and linkage disequilibrium (non-random associations of alleles at different loci or LD). The understanding of these patterns is crucial to two of the most important challenges facing biomedical science today: the identification of disease predisposing genes and prediction of variable drug reactions. The genetic variation revealed by these endeavours can also illuminate the underlying population historical processes. Here, I illustrate each of these applications: first, by assessing the demographic context of cultural change in the British Isles. Y chromosome variation indicates that the Viking age invasions left a significant paternal legacy (at least in Orkney), while the Neolithic and Iron Age cultural transitions did not. In contrast, mitochondrial DNA and X chromosome variation indicate that one or more of these pre-Anglo-Saxon revolutions had a major effect on the maternal genetic heritage of the British Isles. Second, I provide conclusive evidence that diverse demographic histories produce strikingly different patterns of association. Elevated LD extends an order of magnitude further in the Lemba, a Bantu-Semitic hybrid population, than in the putative parental populations. A significant relationship between allele-frequency differentials in the parental populations and the Lemba LD demonstrates that it is admixture-generated. Third, I demonstrate that the genetic structure inferred in a heterogeneous sample using neutral markers (a) shows ethnic labels to be inaccurate descriptions of human population structure, and (b) predicts drug metabolising profiles, defined by the distribution of drug metabolising enzyme variants. Thus the trade-off between therapeutic response and adverse drug reactions will differ between different sub-clusters. Assessment of genetic structure during drug trials is therefore, like the empirical evaluation of each population’s pattern of LD, a necessity.
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Siska, Veronika. "Human population history and its interplay with natural selection." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/284164.
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The complex demographic changes that underlie the expansion of anatomically modern humans out of Africa have important consequences on the dynamics of natural selection and our ability to detect it. In this thesis, I aimed to refine our knowledge on human population history using ancient genomes, and then used a climate-informed, spatially explicit framework to explore the interplay between complex demographies and selection. I first analysed a high-coverage genome from Upper Palaeolithic Romania from ~37.8 kya, and demonstrated an early diversification of multiple lineages shortly after the out-of-Africa expansion (Chapter 2). I then investigated Late Upper Palaeolithic (~13.3ky old) and Mesolithic (~9.7 ky old) samples from the Caucasus and a Late Upper Palaeolithic (~13.7ky old) sample from Western Europe, and found that these two groups belong to distinct lineages that also diverged shortly after the out of Africa, ~45-60 ky ago (Chapter 3). Finally, I used East Asian samples from ~7.7ky ago to show that there has been a greater degree of genetic continuity in this region compared to Europe (Chapter 4). In the second part of my thesis, I used a climate-informed, spatially explicit demographic model that captures the out-of-Africa expansion to explore natural selection. I first investigated whether the model can represent the confounding effect of demography on selection statistics, when applied to neutral part of the genome (Chapter 5). Whilst the overlap between different selection statistics was somewhat underestimated by the model, the relationship between signals from different populations is generally well-captured. I then modelled natural selection in the same framework and investigated the spatial distribution of two genetic variants associated with a protective effect against malaria, sickle-cell anaemia and β⁰ thalassemia (Chapter 6). I found that although this model can reproduce the disjoint ranges of different variants typical of the former, it is incompatible with overlapping distributions characteristic of the latter. Furthermore, our model is compatible with the inferred single origin of sickle-cell disease in most regions, but it can not reproduce the presence of this disorder in India without long-distance migrations.
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Bycroft, Clare. "Genomic data analyses for population history and population health." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:c8a76d94-ded6-4a16-b5af-09bbad6292a2.
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Many of the patterns of genetic variation we observe today have arisen via the complex dynamics of interactions and isolation of historic human populations. In this thesis, we focus on two important features of the genetics of populations that can be used to learn about human history: population structure and admixture. The Iberian peninsula has a complex demographic history, as well as rich linguistic and cultural diversity. However, previous studies using small genomic regions (such as Y-chromosome and mtDNA) as well as genome-wide data have so far detected limited genetic structure in Iberia. Larger datasets and powerful new statistical methods that exploit information in the correlation structure of nearby genetic markers have made it possible to detect and characterise genetic differentiation at fine geographic scales. We performed the largest and most comprehensive study of Spanish population structure to date by analysing genotyping array data for ~1,400 Spanish individuals genotyped at ~700,000 polymorphic loci. We show that at broad scales, the major axis of genetic differentiation in Spain runs from west to east, while there is remarkable genetic similarity in the north-south direction. Our analysis also reveals striking patterns of geographically-localised and subtle population structure within Spain at scales down to tens of kilometres. We developed and applied new approaches to show how this structure has arisen from a complex and regionally-varying mix of genetic isolation and recent gene-flow within and from outside of Iberia. To further explore the genetic impact of historical migrations and invasions of Iberia, we assembled a data set of 2,920 individuals (~300,000 markers) from Iberia and the surrounding regions of north Africa, Europe, and sub-Saharan Africa. Our admixture analysis implies that north African-like DNA in Iberia was mainly introduced in the earlier half (860 - 1120 CE) of the period of Muslim rule in Iberia, and we estimate that the closest modern-day equivalents to the initial migrants are located in Western Sahara. We also find that north African-like DNA in Iberia shows striking regional variation, with near-zero contributions in the Basque regions, low amounts (~3%) in the north east of Iberia, and as high as (~11%) in Galicia and Portugal. The UK Biobank project is a large prospective cohort study of ~500,000 individuals from across the United Kingdom, aged between 40-69 at recruitment. A rich variety of phenotypic and health-related information is available on each participant, making the resource unprecedented in its size and scope. Understanding the role that genetics plays in phenotypic variation, and its potential interactions with other factors, provides a critical route to a better understanding of human biology and population health. As such, a key component of the UK Biobank resource has been the collection of genome-wide genetic data (~805,000 markers) on every participant using purpose-designed genotyping arrays. These data are the focus of the second part of this thesis. In particular, we designed and implemented a quality control (QC) pipeline on behalf of the current and future use of this multi-purpose resource. Genotype data on this scale offers novel opportunities for assessing quality issues, although the wide range of ancestral backgrounds in the cohort also creates particular challenges. We also conducted a set of analyses that reveal properties of the genetic data, including population structure and familial relatedness, that can be important for downstream analyses. We find that cryptic relatedness is common among UK Biobank participants (~30% have at least one first cousin relative or closer), and a full range of human population structure is present in this cohort: from world-wide ancestral diversity to subtle population structure at sub-national geographic scales. Finally, we performed a genome-wide association scan on a well-studied and highly polygenic phenotype: standing height. This provided a further test of the effectiveness of our QC, as well as highlighting the potential of the resource to uncover novel regions of association.
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Beckley, Julia Ruth. "How Cultural Factors Hastened the Population Decline of the Powhatan Indians." VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1553.
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Solé, Morata Neus 1988. "Inferring recent human population history from a Y chromosome perspective." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/543846.
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The Y chromosome is the longest non-recombining DNA sequence of the human genome. This avoidance of recombination, together with its paternal inheritance, makes the Y chromosome a powerful tool with which to study population history, male genealogy, forensics and medical genetics. Besides the progress made in the field during the last two decades, the recent advent of massive parallel sequencing (MPS) has yielded the discovery of thousands of new variants that have allowed to build a more reliable phylogeny and to obtain direct estimates of its mutation rate. In the present thesis, I analyse the Y-chromosome diversity from two different perspectives and with different purposes. First, by targeting specific SNPs and STRs in ~ 2,500 men bearing one of the selected 50 Catalan surnames, we investigated the driving forces behind the origin, systematization, and diffusion of surnames. And then, by using whole Y-chromosome sequences from North African individuals belonging to the most frequent lineage in the area (E-M183), we have been able to refine the phylogeography of this lineage and to shed light on the controversial dates for its origin and spread.El comportament únic del cromosoma Y, heretat per via paterna sense patir recombinació amb cap altre cromosoma, el converteix en un marcador excepcional amb aplicacions en àmbits com la genètica de poblacions humanes, la genealogia o la genètica forense. Tot i el progrés en l’estudi del cromosoma Y realitzat en les últimes dues dècades, el recent desenvolupament de les tecnologies de seqüenciació massiva ha permès el descobriment de milers de noves variants, mitjançant les quals s’ha obtingut una millor reconstrucció filogenètica, així com una estimació directa de la seva taxa de mutació. En aquesta tesi s’analitza la diversitat del cromosoma Y des de dues perspectives diferents i amb els següents propòsits. En primer lloc, mitjançant el genotipat de marcadors específics del cromosoma Y en ~2500 homes portadors d’un dels 50 cognoms catalans escollits, s’han investigat els processos que han donat lloc a l’origen, la sistematització i la difusió dels cognoms. Per altra banda, la seqüenciació de cromosomes Y en homes nord africans pertanyents al llinatge més freqüent en aquesta àrea (E-M183), ha permès un refinament de l’estructura filogeogràfica d’aquest llinatge, així com l’establiment temporal del seu origen i dispersió.
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Bergström, Anders. "Genomic insights into the human population history of Australia and New Guinea." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273775.
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The ancient continent of Sahul, encompassing Australia, New Guinea and Tasmania, contains some of the earliest archaeological evidence for humans outside of Africa, dating back to at least 50 thousand years ago (kya). New Guinea was also one of the sites were humans developed agriculture in the last 10 thousand years. Despite the importance of this part of the world to the history of humanity outside Africa, little is known about the population history of the people living here. In this thesis I present population-genetic studies using whole-genome sequencing and genotype array datasets from more than 500 indigenous individuals from Australia and New Guinea, as well as initial work on large-scale sequencing of other, worldwide, human populations in the Human Genome Diversity Project panel. Other than recent admixture after European colonization of Australia, and Southeast Asian ad- mixture in the lowlands of New Guinea in the last few millennia, the populations of Sahul appear to have been genetically independent from the rest of the world since their divergence ∼50 kya. There is no evidence for South Asian gene flow to Australia, as previously suggested, and the highlands of Papua New Guinea (PNG) have remained unaffected by non-New Guinean gene flow until the present day. Despite Sahul being a single connected landmass until ∼8 kya, different groups across Australia are nearly equally related to Papuans, and vice versa, and the two appear to have separated genetically already ∼30 kya. In PNG, all highlanders strikingly appear to form a clade relative to lowlanders, and population structure seems to have been reshaped, with major population size increases, on the same timescale as the spread of agriculture. However, present- day genetic differentiation between groups is much stronger in PNG than in other parts of the world that have also transitioned to agriculture, demonstrating that such a lifestyle change does not necessarily lead to genetic homogenization. The results presented here provide detailed insights into the population history of Sahul, and sug- gests that its history can serve as an independent source of evidence for understanding human evolutionary trajectories, including the relationships between genetics, lifestyle, languages and culture.
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Moorjani, Priya. "Genetic Study of Population Mixture and Its Role in Human History." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10932.
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Mixture between populations is an evolutionary process that shapes genetic variation. Intermixing between groups of distinct ancestries creates mosaics of chromosomal segments inherited from multiple ancestral populations. Studying populations of mixed ancestry (admixed populations) is of special interest in population genetics as it not only provides insights into the history of admixed groups but also affords an opportunity to reconstruct the history of the ancestral populations, some of whom may no longer exist in unmixed form. Furthermore, it improves our understanding of the impact of population migrations and helps us discover links between genetic and phenotypic variation in structured populations. The majority of research on admixed populations has focused on African Americans and Latinos where the mixture is recent, having occurred within the past 500 years. In this dissertation, I describe several studies that I have led that expand the scope of admixed studies to West Eurasians and South Asians where the mixture is older, and data from ancestral groups is mostly unavailable. First, I introduce a novel method that studies admixture linkage disequilibrium (LD) to infer the time of mixture. I analyze genomewide data from 40 West Eurasian populations and show that all Southern European, Levantine and Jewish groups have inherited sub-Saharan African ancestry in the past 100 generations, likely reflecting events during the Roman Empire and subsequent Arab migrations. Next, I apply a range of methods to study the history of Siddi groups that harbor African, Indian and Portuguese ancestry, and to infer the history of Roma gypsies from Europe. Finally, I develop a novel approach that combines the insights of frequency and LD-based statistics to infer the underlying model of mixture. I apply this method to 73 South Asian groups and infer that major mixture occurred ~2,000-4,000 years ago. In a subset of populations, all the mixture occurred during this period, a time of major change in India marked by the de- urbanization of the Indus valley civilization and recolonization of the Gangetic plateau. Inferences from our analyses provide novel insights into the history of these populations as well as about the broad impact of human migrations.
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Haber, Marc 1980. "Study of human genetic diversity : inferences on population origin and history." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/127113.
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Patterns of human genetic diversity suggest that all modern humans originated from a small population in Africa that expanded rapidly 50,000 years ago to occupy the whole world. While moving into new environments, genetic drift and natural selection affected populations differently, creating genetic structure. By understanding the genetic structure of human populations, we can reconstruct human history and understand the genetic basis of diseases. The work presented here contributes to the ongoing effort to catalogue human genetic diversity by exploring populations that have been underrepresented in genetic studies. We use variations on the genomes of populations from Central Asia, the Near East, and North Africa to reconstruct the history of these populations. We find that climate change and geography appear to be major factors shaping genetic diversity. In addition, we identify recent cultural developments and historical events that have influenced admixture and gene flow between populations, leading to the genetic diversity observed in humans today.Els patrons de diversitat genètica humana suggereixen que els humans van sorgir d’un petit grup a l’Àfrica que es va expandir ràpidament fa uns 50,000 anys per tot el planeta. En migrar cap a nous hàbitats, la deriva genètica i la selecció natural van afectar de manera diferencial les poblacions, generant una estructura genètica. Mitjançant la comprensió de l’estructura genètica de les poblacions podem reconstruir la història humana i entendre la base genètica de les malalties. Aquest treball contribueix a l’esforç continu de catalogar la diversitat genètica humana explorant poblacions poc representades en altres estudis genètics. Hem utilitzat variacions al llarg del genoma de poblacions d’Àsia Central, Orient Mitjà i el Nord d’Àfrica per tal de reconstruir la seva història. Hem observat que canvis climàtics i geogràfics semblen ser els factors principals que han modelat la diversitat genètica. A més, hem identificat esdeveniments culturals i històrics recents que afavorit les barreges i el flux genètic entre poblacions, generant la diversitat genètica observada avui en dia.
Books on the topic "Human population history of Indians"
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Old souls in a new world: The secret history of the Cherokee Indians. Phoenix: Panther's Lodge, 2013.
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Fernán González de la Vara. caida de Teotihuacan valle de Toluca hasta la caída de Teotihuacan. México, D.F: Instituto Nacional de Antropología e Historia, 1999.
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Stojanowski, Christopher M. Bioarchaeology of ethnogenesis in the colonial Southeast. Gainesville: University Press of Florida, 2010.
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Stojanowski, Christopher M. Bioarchaeology of ethnogenesis in the colonial Southeast. Gainesville: University Press of Florida, 2010.
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Stojanowski, Christopher M. Bioarchaeology of ethnogenesis in the colonial Southeast. Gainesville: University Press of Florida, 2010.
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Bioarchaeology of ethnogenesis in the colonial Southeast. Gainesville: University Press of Florida, 2010.
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Demographic perspectives on India's tribes. New Delhi: New York, 2005.
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Biocultural histories in La Florida: A bioarchaeological perspective. Tuscaloosa: University of Alabama Press, 2005.
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Skeletons in our closet: Revealing our past through bioarchaeology. Princeton, N.J: Princeton University Press, 2000.
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Indigenous South Americans of the past and present: An ecological perspective. Boulder, Colo: Westview Press, 1999.
Find full textBook chapters on the topic "Human population history of Indians"
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Wall, Jeffrey D. "Inferring Human Demographic History from Genetic Data." In Human Population Genomics, 187–204. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-61646-5_8.
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Relethford, John H. "Human Population Structure and History." In A Companion to Anthropological Genetics, 121–35. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2019. http://dx.doi.org/10.1002/9781118768853.ch9.
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Marciniak, Stephanie, and Hendrik N. Poinar. "Ancient Pathogens Through Human History: A Paleogenomic Perspective." In Population Genomics, 115–38. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/13836_2018_52.
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McCorriston, Joy, and Louise Martin. "Southern Arabia’s Early Pastoral Population History: Some Recent Evidence." In The Evolution of Human Populations in Arabia, 237–50. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2719-1_17.
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Zilversmit, Martine, and Daniel L. Hartl. "Evolutionary History and Population Genetics of Human Malaria Parasites." In Molecular Approaches to Malaria, 95–109. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555817558.ch7.
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Chaudhuri, Plaban, Riju Ghosh, Mithun Das, Indrani Lodh, and Riddhi Goswami. "Effect of Metabolic Risk Factors, Gene Polymorphisms and Family History Among T2DM Population in Asian Indians." In Lecture Notes in Bioengineering, 143–50. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-7409-2_14.
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Foley, Charles A. H., and Lara S. Foley. "The History, Status, and Conservation of the Elephant Population in the Tarangire Ecosystem." In Tarangire: Human-Wildlife Coexistence in a Fragmented Ecosystem, 209–32. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-93604-4_10.
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Tsai, Ming-Chi, Guy Blelloch, R. Ravi, and Russell Schwartz. "A Consensus Tree Approach for Reconstructing Human Evolutionary History and Detecting Population Substructure." In Bioinformatics Research and Applications, 167–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13078-6_20.
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Rivero-Cantillano, Rodrigo, and Manuel Llorca-Jaña. "Population, Biological Welfare and Human Capital in Norway, Sweden, Bolivia, Chile and Peru During the Nineteenth and Twentieth Centuries." In Palgrave Studies in Economic History, 143–67. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71044-6_6.
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Lancaster, Jane B. "The Evolutionary History of Human Parental Investment in Relation to Population Growth and Social Stratification." In Feminism and Evolutionary Biology, 466–88. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5985-6_19.
Full textConference papers on the topic "Human population history of Indians"
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Uslu, Kamil. "The History of the Cannabis Plant, its Place in the Economies of Countries, and its Strategic Importance." In International Conference on Eurasian Economies. Eurasian Economists Association, 2022. http://dx.doi.org/10.36880/c14.02694.
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Cannabis is a plant that is extraordinarily useful and has been used in almost every form for thousands of years by mankind. It is a small family of flowering plants, also known as the cannabis family. This family contains about 170 species grouped in about 11 genera, including Cannabis, Humulus, and Celtis. Obtaining the drug, which is a by-product of cannabis, is shown as a potential danger to societies. Despite this, it should not be ignored that hemp is gaining more importance in our global world. The economic and social benefits of cannabis, which are very important in human history, still maintain their place today. It can be said that political preferences are more prominent here. Cannabis has been freely used by a large part of the world's population since prehistoric times. There are countries that stand out in the history of hemp. These; Among the Chinese, Indians, the Native Americans are prominent. The areas where cannabis is used; It acts as a natural filter in paper production, textile industry, agriculture, energy, automotive industry, cleaning carbon dioxide in the air. In addition, hemp, which is widely used in medicine, is a strategic plant that is also used in many areas.
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Bosch, V., N. Bosch, M. Valles, N. Ortíz, and R. Gómez. "FATTY ACIDS AND PLATELET FUNCTION IN A SOUTH AMERICAN INDIAN GROUP WITH A HIGH DIETARY CONSUMPTION OF DOCOSAHEXAENOIC ACID." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643403.
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The effect of dietary polyunsaturated fatty acids on hemostasis has elicited much interest. We studied indians from the Orinoco river shore, whose main animal protein intake derives from river fishes with a high confceqt of 22:6n-3 (0.2g/100g)r We determined in 50 indians plasma phospholipid fatty acids (FApl) by gas/liq chromatography and bleeding time by Symplate I divice (BT), in 15 were analyzed platelet count, aggregation with collagen and ADP, platelet factor 3 availability (PF3), platelet phospolipid fatty acids (FApt) and plasma vWFAg.RA from human milk was also determined. Subjets from the city of Caracas served as control. Data on BT, FAlp and FApt are shown in table (X±SD).FA Composition of milk showed that indians have 3 times more 22: 6n-3 than controls. Platelet studies shewed normal number and morphology. Percent platelet aggregation with collagen (4ug/ml) was below 50% in 4 of indians, 2 of them with a BT within the control range. Maximum slope of aggregation with ADP (4uM) was diminished in 2 cases. Diference in PF3 was not significant, VWFAg range from 50 to 100% and control from 53 to 127%. In conclusion we have found a population that shows an increased plasma and platelet 22:6n-3 and a prolonged BT most likely of dietary origen. Mechanism by wich n-3 FA modifies BT needs fur ther investigation.
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Kowarsch, Dandan, and Zining Yang. "A System Dynamics Approach on Modeling Homeless Prevention Strategy: A Case Study of LA County." In Intelligent Human Systems Integration (IHSI 2022) Integrating People and Intelligent Systems. AHFE International, 2022. http://dx.doi.org/10.54941/ahfe100986.
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This article presents a system dynamic modeling approach to simulate the effect of a homeless prevention strategy on the homeless population in Los Angeles. Despite the implementation of rehousing strategy suggested by policy makers, the Los Angeles homeless population has increased over time. Traditional statistics analysis is widely used in researching this topic, but using aggregated data fails to provide sufficient explanations on the correlation between the permanent supportive housing and homeless population. Our system dynamics model overcomes this challenge in a unique way using stocks and flows. We model stocks as key factors that have significant impact on homelessness, including prevented homeless population, the population of the homeless who are in the temporary housing programs, and the population of those who are settled in the permanent supportive housing program. Flows provide details on how stocks are related to each other, allowing memories of the history and interconnection in the homeless system. Each stock may affect the other due to time delays and feedback loops through inflows and outflows. To assess the impact of homeless prevention programs, we perform simulation and scenario analysis by adjusting model inputs including ratios for prevented homelessness and the rapid re-housing. The system dynamics model helps unveil the unintended consequence introduced by the Housing-First policy and allows us to evaluate various policies to come up with data-driven recommendations. The simulation results suggest that prevention strategy could lead to a positive impact on reducing the homeless population. Indeed, the use of Housing-First policy along with a preventative program for homelessness could be considered as a more effective strategy for the mitigation of LA homelessness.
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Pizarro, Jorge, Byron Vásquez, Willan Steven Mendieta Molina, and Remigio Hurtado. "Hepatitis predictive analysis model through deep learning using neural networks based on patient history." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1001449.
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First of all, one of the applications of artificial intelligence is the prediction of diseases, including hepatitis. Hepatitis has been a recurring disease over the years as it seriously affects the population, increasing by 125,000 deaths per year. This process of inflammation and damage to the organ affects its performance, as well as the functioning of the other organs in the body. In this work, an analysis of variables and their influence on the objective variable is made, in addition, results are presented from a predictive model.We propose a predictive analysis model that incorporates artificial neural networks and we have compared this prediction method with other classification-oriented models such as support vector machines (SVM) and genetic algorithms. We have conducted our method as a classification problem. This method requires a prior process of data processing and exploratory analysis to identify the variables or factors that directly influence this type of disease. In this way, we will be able to identify the variables that intervene in the development of this disease and that affect the liver or the correct functioning of this organ, presenting discomfort to the human body, as well as complications such as liver failure or liver cancer. Our model is structured in the following steps: first, data extraction is performed, which was collected from the machine learning repository of the University of California at Irvine (UCI). Then these data go through a variable transformation process. Subsequently, it is processed with learning and optimization through a neural network. The optimization (fine-tuning) is performed in three phases: complication hyperparameter optimization, neural network layer density optimization, and finally dropout regularization optimization. Finally, the visualization and analysis of results is carried out. We have used a data set of patient medical records, among the variables are: age, sex, gender, hemoglobin, etc. We have found factors related either indirectly or directly to the disease. The results of the model are presented according to the quality measures: Recall, Precision and MAE.We can say that this research leaves the doors open to new challenges such as new implementations within the field of medicine, not only focused on the liver, but also being able to extend the development environment to other applications and organs of the human body in order to avoid risks possible, or future complications. It should be noted that the future of applications with the use of artificial neural networks is constantly evolving, the application of improved models such as the use of random forests, assembly algorithms show a great capacity for application both in biomedical engineering and in focused areas to the analysis of different types of medical images.
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Isupov, V. "Birth Rate and Marriage in Wartime Conditions (Rear Population of the RSFSR), 1939-1945." In XIII Ural Demographic Forum. GLOBAL CHALLENGES TO DEMOGRAPHIC DEVELOPMENT. Institute of Economics of the Ural Branch of RAS, 2022. http://dx.doi.org/10.17059/udf-2022-1-10.
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Historical demography in Russia as a scientific field is experiencing rapid growth. Since the late 1980s, numerous works have been published on various issues of demographic history. Considerable attention is now being paid to the demographic aspects of the World War II. While the issue of human losses in the USSR is of great interest, much less attention is drawn to the problem of population reproduction in 1939-1945. Simultaneously, reproduction processes underwent such a significant distortion during the war years that they should be taken into account when determining the scale of the demographic catastrophe that shook Russia. The main purpose of this article is to identify the leading trends and features of marriage and birth rate of the Russian population during the World War II.
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MARTSENIUK, Maryna. "ON THE INFLUENCE OF HAPPINESS ON HUMAN HEALTH." In Happiness And Contemporary Society : Conference Proceedings Volume. SPOLOM, 2021. http://dx.doi.org/10.31108/7.2021.42.
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The article considers the concept and phenomen on of happiness from the perspective of different authors. The subjective perception and interpretation of the term happiness and the vital interest in this phenomen on by such sciences as philosophy, ethics, psychology, history, medicine. The concept of happiness in a narrow (fate, talent, luck, success, joy) and broad (psycho-emotional state of complete satisfaction with life, a sense of complete joy) senses has been covered. The ratings of the countries on the level of happiness among population (WorldHappinessReport) and the «happiness index» studied by the international foundation NEF (NewEconomicsFoundation) have been analyzed, along with the position of Ukraine. The finding soft helongest-running study from Harvard University, which aimed to find out what makes people happy from adolescence to old age, have been presented. It has been found that good relationships with people make us happier and healthier. Good social connections are good for us, but loneliness shortens life. It was proved that the happiest of the participants in the experiment, even feeling physicalpain, stayed positive. In stead, un happy people feltthat the physical pain became even stronger dueto a bad emotional state. The importance of a spouse supporting, and its positive impact on such a process as memory was emphasized. Instead, it was noted that their memory did not deteriorate as rapidly as in single people. Key words: health, life satisfaction, feelings of happiness, level of happiness.
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AbdalKhabir Ali, Ali, and Hajar Salah Auda. "The effect of marsh draining on biodiversity." In Peacebuilding and Genocide Prevention. University of Human Development, 2021. http://dx.doi.org/10.21928/uhdicpgp/64.
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"The marsh represents a rare natural environment of its kind for a number of reasons. First, the marshes were the cradle of the Sumerian civilization and an environment that embraces a unique biodiversity. Its geography and vast area, which is equivalent to the size of a country like Lebanon, made it a resting place and provided food and reproduction for migratory birds. It is worthy of being included in the World Heritage List as one of the treasures of the world that must be preserved, but unfortunately, the Iraqi marshes have not been subjected throughout history to extensive and systematic drying operations, which reached 95% of their total area, as they were exposed to during the era of the previous dictatorial regime in the nineties of last century, which led to the emergence of a number of environmental problems that collectively led to the disruption of natural ecological balance through the loss of the ability to achieve the environmental balance and causing biological diversity damage . This is as a result of the lack of incoming water resources and the high percentage of salinity and pollution, which caused the death of huge numbers of wildlife and aquatic life, as well as the extinction of large numbers of them, causing a mass migration of the population of those areas to other areas that provide them with a minimum standard of decent living after they lost their main sources of livelihood represented by fishing and raising animals. The paper aims to present a study on the impact of the widespread and systematic drying stages that began after the Iran-Iraq war in the eighties of last century and culminated in the nineties, bringing the percentage of the remaining water from the marshes to 5% in 2002, and the extent of its impact on the destruction of the environment and biodiversity, which includes humans and animals, as well as migratory birds from Siberia to the Indian subcontinent, which lost their habitats and places for laying eggs and breeding. It will also present a number of solutions that will help reduce the environmental degradation that the marshes have been exposed to."
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Patnaik, Sourav S., Benjamin Weed, Ali Borazjani, Robbin Bertucci, Mark Begonia, Bo Wang, Lakiesha Williams, and Jun Liao. "Biomechanical Characterization of Sheep Vaginal Wall Tissue: A Potential Application in Human Pelvic Floor Disorders." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80886.
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Pelvic Organ Prolapse (POP) is a leading women’s health issue affecting a significant portion of the population and has been recently coined as a “silent epidemic”. POP leads to a considerable reduction in women’s quality of life and can cause chronic pelvic pain, sexual dysfunction, and social/psychological issues. The lifetime risk for having surgery for POP is approximately 11% with 200,000 POP procedures performed each year in USA, with an annual direct cost of over $1000 million. Exact etiology of POP is unclear, but it is understood that POP is multi-factorial in nature. Risk factors for POP include increasing age, obesity, multiple vaginal births, gravidity, history of hysterectomy, smoking, chronic cough conditions, frequent heavy lifting, and some genetic factors. POP results due to loss or damage of structural supports that support the pelvic organs (i.e. rectum, bowel, bladder, etc). Vaginal wall prolapse (anterior and posterior) is the most common presentation. This can result from weakening of the levator ani muscle and other connective tissue structures which not only control the mechanical function, but also help support neurological and anatomical function[1].
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Graham, J. B., D. B. Lubahn, J. D. Kirshtein, S. T. Lord, I. M. Nilsson, A. Wallmark, R. Ljung, et al. "THE “MALMO“ EPITOPE OF FACTOR IX: PHENOTYPIC EXPRESSION OF THE “VIKING“ GENE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643566.
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The epitope of a mouse monoclonal AB (9.9) which detects a Factor IX (F.IX) polymorphism in the plasma of normal persons (PNAS 82:3839, 1985) has been related to not more than 6 AA residues of F.IX by recombinant DNA technology. The same 6 residues define Smith’s polymorphic epitope (Am. J. Human Genet. 37:688, 1985 and in press). This region of F.IX contains the alanine:threonine dimorphism at residue 148 first suggested by McGraw et al. (PNAS 82: 2847, 1985) and established by Winship and Brownlee with synthetic DNA oligomers (Lancet in press). Using synthetic DNA probes, we have found that the DNA difference between positive and negative reactors to 9.9 is whether base pair 20422, the first pair in the codon for residue 148, is A:T or G:C. We can conclude that 9.9 reacts with F.IX containing threonine but not alanine at position 148.The F.IX immunologic polymorphism-whose epitope we are referring to as “Malmo”-is, not surprisingly, in strong linkage disequilibrium with two F.IX DNA polymorphisms, TaqI and Xmnl. The highest frequency of the rarer Malmo allele in 6 disparate ethnic groups was in Swedes (32%); a lower frequency (14%) was seen in White Americans whose ancestors came overwhelmingly from the Celtic regions of the British Isles; it was at very low frequency or absent in Black Americans, East Indians, Chinese and Malays. A maximum frequency in Swedes and absence in Africans and Orientals suggest that the transition from A:T to G:C occurred in Scandinavia and spread from there. The history of Europe and America plus the geographical distribution of the rare allele lead us to suggest that this locus might be designated: “the Viking gene”.
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Anisah, Wafie, and Filosa Gita Sukmono. "Promotional Strategies of Local Governments in Improving Tourists’ Post Pandemic Experience: Case Study in Yogyakarta, Indonesia." In 8th International Conference on Human Interaction and Emerging Technologies. AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1002769.
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This study aims to find out how to manage the official Twitter social media account of the Indonesian local government after the pandemic. Twitter has become an important part of the government’s social media, one of which is an effective tourism industry promotion medium. This condition is supported by Indonesian social media users reaching 170 million of the total population. Therefore, the authors to look at how social media work for the Yogyakarta City Government, creating tourism industry promotion after the COVID-19 pandemic. This study used a Qualitative Data Analysis Software approach, with NvivoPlus 12 as the data analysis tool. The source of this research data came from @humas_jogja, the official Twitter account of the Yogyakarta City Government. The findings of this study indicated that, first, social media worked well as a tourism industry promotion medium for Yogyakarta after the pandemic. Second, as a communication medium, the Yogyakarta City Government encourages people to be vaccinated before traveling to Yogyakarta. Third, as a medium for mitigation tourism industry, new adaptations are promoted through the health protocol campaign while traveling to Yogyakarta. Fourth, as an educational medium, @humas_jogja encourages history-based tourism industry for students. These findings are based the intensity of information submitted by the @humas_jogja account using the tagline of special areas as a characteristic of Yogyakarta.
Reports on the topic "Human population history of Indians"
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Harris, Bernard. Anthropometric history and the measurement of wellbeing. Verlag der Österreichischen Akademie der Wissenschaften, June 2021. http://dx.doi.org/10.1553/populationyearbook2021.rev02.
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It has often been recognised that the average height of a population is influencedby the economic, social and environmental conditions in which it finds itself, andthis insight has inspired a generation of historians to use anthropometric data toinvestigate the health and wellbeing of past populations. This paper reviews someof the main developments in the field, and assesses the extent to which heightremains a viable measure of historical wellbeing. It explores a number of differentissues, including the nature of human growth; the impact of variations in diet andexposure to disease; the role of ethnicity; the relationships between height, mortalityand labour productivity; and the “social value” of human stature. It concludes that,despite certain caveats, height has retained its capacity to act as a “mirror” of theconditions of past societies, and of the wellbeing of their members.
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Rankin, Nicole, Deborah McGregor, Candice Donnelly, Bethany Van Dort, Richard De Abreu Lourenco, Anne Cust, and Emily Stone. Lung cancer screening using low-dose computed tomography for high risk populations: Investigating effectiveness and screening program implementation considerations: An Evidence Check rapid review brokered by the Sax Institute (www.saxinstitute.org.au) for the Cancer Institute NSW. The Sax Institute, October 2019. http://dx.doi.org/10.57022/clzt5093.
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Background Lung cancer is the number one cause of cancer death worldwide.(1) It is the fifth most commonly diagnosed cancer in Australia (12,741 cases diagnosed in 2018) and the leading cause of cancer death.(2) The number of years of potential life lost to lung cancer in Australia is estimated to be 58,450, similar to that of colorectal and breast cancer combined.(3) While tobacco control strategies are most effective for disease prevention in the general population, early detection via low dose computed tomography (LDCT) screening in high-risk populations is a viable option for detecting asymptomatic disease in current (13%) and former (24%) Australian smokers.(4) The purpose of this Evidence Check review is to identify and analyse existing and emerging evidence for LDCT lung cancer screening in high-risk individuals to guide future program and policy planning. Evidence Check questions This review aimed to address the following questions: 1. What is the evidence for the effectiveness of lung cancer screening for higher-risk individuals? 2. What is the evidence of potential harms from lung cancer screening for higher-risk individuals? 3. What are the main components of recent major lung cancer screening programs or trials? 4. What is the cost-effectiveness of lung cancer screening programs (include studies of cost–utility)? Summary of methods The authors searched the peer-reviewed literature across three databases (MEDLINE, PsycINFO and Embase) for existing systematic reviews and original studies published between 1 January 2009 and 8 August 2019. Fifteen systematic reviews (of which 8 were contemporary) and 64 original publications met the inclusion criteria set across the four questions. Key findings Question 1: What is the evidence for the effectiveness of lung cancer screening for higher-risk individuals? There is sufficient evidence from systematic reviews and meta-analyses of combined (pooled) data from screening trials (of high-risk individuals) to indicate that LDCT examination is clinically effective in reducing lung cancer mortality. In 2011, the landmark National Lung Cancer Screening Trial (NLST, a large-scale randomised controlled trial [RCT] conducted in the US) reported a 20% (95% CI 6.8% – 26.7%; P=0.004) relative reduction in mortality among long-term heavy smokers over three rounds of annual screening. High-risk eligibility criteria was defined as people aged 55–74 years with a smoking history of ≥30 pack-years (years in which a smoker has consumed 20-plus cigarettes each day) and, for former smokers, ≥30 pack-years and have quit within the past 15 years.(5) All-cause mortality was reduced by 6.7% (95% CI, 1.2% – 13.6%; P=0.02). Initial data from the second landmark RCT, the NEderlands-Leuvens Longkanker Screenings ONderzoek (known as the NELSON trial), have found an even greater reduction of 26% (95% CI, 9% – 41%) in lung cancer mortality, with full trial results yet to be published.(6, 7) Pooled analyses, including several smaller-scale European LDCT screening trials insufficiently powered in their own right, collectively demonstrate a statistically significant reduction in lung cancer mortality (RR 0.82, 95% CI 0.73–0.91).(8) Despite the reduction in all-cause mortality found in the NLST, pooled analyses of seven trials found no statistically significant difference in all-cause mortality (RR 0.95, 95% CI 0.90–1.00).(8) However, cancer-specific mortality is currently the most relevant outcome in cancer screening trials. These seven trials demonstrated a significantly greater proportion of early stage cancers in LDCT groups compared with controls (RR 2.08, 95% CI 1.43–3.03). Thus, when considering results across mortality outcomes and early stage cancers diagnosed, LDCT screening is considered to be clinically effective. Question 2: What is the evidence of potential harms from lung cancer screening for higher-risk individuals? The harms of LDCT lung cancer screening include false positive tests and the consequences of unnecessary invasive follow-up procedures for conditions that are eventually diagnosed as benign. While LDCT screening leads to an increased frequency of invasive procedures, it does not result in greater mortality soon after an invasive procedure (in trial settings when compared with the control arm).(8) Overdiagnosis, exposure to radiation, psychological distress and an impact on quality of life are other known harms. Systematic review evidence indicates the benefits of LDCT screening are likely to outweigh the harms. The potential harms are likely to be reduced as refinements are made to LDCT screening protocols through: i) the application of risk predication models (e.g. the PLCOm2012), which enable a more accurate selection of the high-risk population through the use of specific criteria (beyond age and smoking history); ii) the use of nodule management algorithms (e.g. Lung-RADS, PanCan), which assist in the diagnostic evaluation of screen-detected nodules and cancers (e.g. more precise volumetric assessment of nodules); and, iii) more judicious selection of patients for invasive procedures. Recent evidence suggests a positive LDCT result may transiently increase psychological distress but does not have long-term adverse effects on psychological distress or health-related quality of life (HRQoL). With regards to smoking cessation, there is no evidence to suggest screening participation invokes a false sense of assurance in smokers, nor a reduction in motivation to quit. The NELSON and Danish trials found no difference in smoking cessation rates between LDCT screening and control groups. Higher net cessation rates, compared with general population, suggest those who participate in screening trials may already be motivated to quit. Question 3: What are the main components of recent major lung cancer screening programs or trials? There are no systematic reviews that capture the main components of recent major lung cancer screening trials and programs. We extracted evidence from original studies and clinical guidance documents and organised this into key groups to form a concise set of components for potential implementation of a national lung cancer screening program in Australia: 1. Identifying the high-risk population: recruitment, eligibility, selection and referral 2. Educating the public, people at high risk and healthcare providers; this includes creating awareness of lung cancer, the benefits and harms of LDCT screening, and shared decision-making 3. Components necessary for health services to deliver a screening program: a. Planning phase: e.g. human resources to coordinate the program, electronic data systems that integrate medical records information and link to an established national registry b. Implementation phase: e.g. human and technological resources required to conduct LDCT examinations, interpretation of reports and communication of results to participants c. Monitoring and evaluation phase: e.g. monitoring outcomes across patients, radiological reporting, compliance with established standards and a quality assurance program 4. Data reporting and research, e.g. audit and feedback to multidisciplinary teams, reporting outcomes to enhance international research into LDCT screening 5. Incorporation of smoking cessation interventions, e.g. specific programs designed for LDCT screening or referral to existing community or hospital-based services that deliver cessation interventions. Most original studies are single-institution evaluations that contain descriptive data about the processes required to establish and implement a high-risk population-based screening program. Across all studies there is a consistent message as to the challenges and complexities of establishing LDCT screening programs to attract people at high risk who will receive the greatest benefits from participation. With regards to smoking cessation, evidence from one systematic review indicates the optimal strategy for incorporating smoking cessation interventions into a LDCT screening program is unclear. There is widespread agreement that LDCT screening attendance presents a ‘teachable moment’ for cessation advice, especially among those people who receive a positive scan result. Smoking cessation is an area of significant research investment; for instance, eight US-based clinical trials are now underway that aim to address how best to design and deliver cessation programs within large-scale LDCT screening programs.(9) Question 4: What is the cost-effectiveness of lung cancer screening programs (include studies of cost–utility)? Assessing the value or cost-effectiveness of LDCT screening involves a complex interplay of factors including data on effectiveness and costs, and institutional context. A key input is data about the effectiveness of potential and current screening programs with respect to case detection, and the likely outcomes of treating those cases sooner (in the presence of LDCT screening) as opposed to later (in the absence of LDCT screening). Evidence about the cost-effectiveness of LDCT screening programs has been summarised in two systematic reviews. We identified a further 13 studies—five modelling studies, one discrete choice experiment and seven articles—that used a variety of methods to assess cost-effectiveness. Three modelling studies indicated LDCT screening was cost-effective in the settings of the US and Europe. Two studies—one from Australia and one from New Zealand—reported LDCT screening would not be cost-effective using NLST-like protocols. We anticipate that, following the full publication of the NELSON trial, cost-effectiveness studies will likely be updated with new data that reduce uncertainty about factors that influence modelling outcomes, including the findings of indeterminate nodules. Gaps in the evidence There is a large and accessible body of evidence as to the effectiveness (Q1) and harms (Q2) of LDCT screening for lung cancer. Nevertheless, there are significant gaps in the evidence about the program components that are required to implement an effective LDCT screening program (Q3). Questions about LDCT screening acceptability and feasibility were not explicitly included in the scope. However, as the evidence is based primarily on US programs and UK pilot studies, the relevance to the local setting requires careful consideration. The Queensland Lung Cancer Screening Study provides feasibility data about clinical aspects of LDCT screening but little about program design. The International Lung Screening Trial is still in the recruitment phase and findings are not yet available for inclusion in this Evidence Check. The Australian Population Based Screening Framework was developed to “inform decision-makers on the key issues to be considered when assessing potential screening programs in Australia”.(10) As the Framework is specific to population-based, rather than high-risk, screening programs, there is a lack of clarity about transferability of criteria. However, the Framework criteria do stipulate that a screening program must be acceptable to “important subgroups such as target participants who are from culturally and linguistically diverse backgrounds, Aboriginal and Torres Strait Islander people, people from disadvantaged groups and people with a disability”.(10) An extensive search of the literature highlighted that there is very little information about the acceptability of LDCT screening to these population groups in Australia. Yet they are part of the high-risk population.(10) There are also considerable gaps in the evidence about the cost-effectiveness of LDCT screening in different settings, including Australia. The evidence base in this area is rapidly evolving and is likely to include new data from the NELSON trial and incorporate data about the costs of targeted- and immuno-therapies as these treatments become more widely available in Australia.
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Saville, Alan, and Caroline Wickham-Jones, eds. Palaeolithic and Mesolithic Scotland : Scottish Archaeological Research Framework Panel Report. Society for Antiquaries of Scotland, June 2012. http://dx.doi.org/10.9750/scarf.06.2012.163.
Full textAbstract:
Why research Palaeolithic and Mesolithic Scotland? Palaeolithic and Mesolithic archaeology sheds light on the first colonisation and subsequent early inhabitation of Scotland. It is a growing and exciting field where increasing Scottish evidence has been given wider significance in the context of European prehistory. It extends over a long period, which saw great changes, including substantial environmental transformations, and the impact of, and societal response to, climate change. The period as a whole provides the foundation for the human occupation of Scotland and is crucial for understanding prehistoric society, both for Scotland and across North-West Europe. Within the Palaeolithic and Mesolithic periods there are considerable opportunities for pioneering research. Individual projects can still have a substantial impact and there remain opportunities for pioneering discoveries including cemeteries, domestic and other structures, stratified sites, and for exploring the huge evidential potential of water-logged and underwater sites. Palaeolithic and Mesolithic archaeology also stimulates and draws upon exciting multi-disciplinary collaborations. Panel Task and Remit The panel remit was to review critically the current state of knowledge and consider promising areas of future research into the earliest prehistory of Scotland. This was undertaken with a view to improved understanding of all aspects of the colonization and inhabitation of the country by peoples practising a wholly hunter-fisher-gatherer way of life prior to the advent of farming. In so doing, it was recognised as particularly important that both environmental data (including vegetation, fauna, sea level, and landscape work) and cultural change during this period be evaluated. The resultant report, outlines the different areas of research in which archaeologists interested in early prehistory work, and highlights the research topics to which they aspire. The report is structured by theme: history of investigation; reconstruction of the environment; the nature of the archaeological record; methodologies for recreating the past; and finally, the lifestyles of past people – the latter representing both a statement of current knowledge and the ultimate aim for archaeologists; the goal of all the former sections. The document is reinforced by material on-line which provides further detail and resources. The Palaeolithic and Mesolithic panel report of ScARF is intended as a resource to be utilised, built upon, and kept updated, hopefully by those it has helped inspire and inform as well as those who follow in their footsteps. Future Research The main recommendations of the panel report can be summarized under four key headings: Visibility: Due to the considerable length of time over which sites were formed, and the predominant mobility of the population, early prehistoric remains are to be found right across the landscape, although they often survive as ephemeral traces and in low densities. Therefore, all archaeological work should take into account the expectation of Palaeolithic and Mesolithic ScARF Panel Report iv encountering early prehistoric remains. This applies equally to both commercial and research archaeology, and to amateur activity which often makes the initial discovery. This should not be seen as an obstacle, but as a benefit, and not finding such remains should be cause for question. There is no doubt that important evidence of these periods remains unrecognised in private, public, and commercial collections and there is a strong need for backlog evaluation, proper curation and analysis. The inadequate representation of Palaeolithic and Mesolithic information in existing national and local databases must be addressed. Collaboration: Multi-disciplinary, collaborative, and cross- sector approaches must be encouraged – site prospection, prediction, recognition, and contextualisation are key areas to this end. Reconstructing past environments and their chronological frameworks, and exploring submerged and buried landscapes offer existing examples of fruitful, cross-disciplinary work. Palaeolithic and Mesolithic archaeology has an important place within Quaternary science and the potential for deeply buried remains means that geoarchaeology should have a prominent role. Innovation: Research-led projects are currently making a substantial impact across all aspects of Palaeolithic and Mesolithic archaeology; a funding policy that acknowledges risk and promotes the innovation that these periods demand should be encouraged. The exploration of lesser known areas, work on different types of site, new approaches to artefacts, and the application of novel methodologies should all be promoted when engaging with the challenges of early prehistory. Tackling the ‘big questions’: Archaeologists should engage with the big questions of earliest prehistory in Scotland, including the colonisation of new land, how lifestyles in past societies were organized, the effects of and the responses to environmental change, and the transitions to new modes of life. This should be done through a holistic view of the available data, encompassing all the complexities of interpretation and developing competing and testable models. Scottish data can be used to address many of the currently topical research topics in archaeology, and will provide a springboard to a better understanding of early prehistoric life in Scotland and beyond.
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Investing in youth: Testing community-based approaches for improving adolescent sexual and reproductive health. Population Council, 1999. http://dx.doi.org/10.31899/rh1999.1019.
Full textAbstract:
The world is now sustaining the largest number of youth in human history; today there are nearly 900 million 10–19-year-olds and their health and livelihood issues are becoming increasingly important to policymakers worldwide. In Zambia, as in many other countries, young people face severe problems, including limited access to jobs, secondary education, and health care. The social, economic, and peer pressures that youth face often lead to high levels of sexual activity, often with subsequent negative impacts on their sexual and reproductive health. In spite of the magnitude of the reproductive health problems facing youth, they still have limited access to effective programs and services to address these problems. In an effort to address this need, CARE Zambia, in collaboration with the Planned Parenthood Association of Zambia and Makeni Ecumenical Center, with technical assistance and funding from the Population Council’s Africa Operations Research and Technical Assistance Project II, have conducted a study to test community-based approaches for improving adolescent sexual and reproductive health. As noted in this report, the study followed a pre-post test design to assess the impact of the interventions and to make comparisons between the different interventions.