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Relevant bibliographies by topics / Human lymphocyte

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Academic literature on the topic 'Human lymphocyte'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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Journal articles on the topic "Human lymphocyte"

1

Schimpff, R. M., and A. M. Repellin. "In vitro effect of human growth hormone on lymphocyte transformation and lymphocyte growth factors secretion." Acta Endocrinologica 120, no. 6 (June 1989): 745–52. http://dx.doi.org/10.1530/acta.0.1200745.

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Abstract. Cultures of human blood peripheral lymphocytes were performed in the presence or absence of human growth hormone, and also of phytohemagglutinin and normal human serum 10%. After incubation for 48 h, the supernatants were tested for their ability to promote the uptake of [3H]thymidine into lectin-activated lymphocytes. Supernatants from lymphocyte-free control samples, treated in the same manner, were assayed under the same experimental conditions. Variance analysis of the different dose-response relationships was performed. The results of these in vitro experiments confirm that physiological levels of GH inhibit the lectin-induced lymphoproliferation and that lymphocytes secrete an 'activity' able to stimulate the incorporation of [3H]thymidine into lectin activated lymphocytes. Furthermore we show that: 1) Secretion of this lymphocyte-stimulating activity is increased by physiological levels of GH; 2) This lymphocytic secretion is not radioimmunoassayable IGF-I; 3) Using fast protein liquid chromatography (FPLC), this activity appears in fractions with various molecular weights.

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Jalkanen, ST, and EC Butcher. "In vitro analysis of the homing properties of human lymphocytes: developmental regulation of functional receptors for high endothelial venules." Blood 66, no. 3 (September 1, 1985): 577–82. http://dx.doi.org/10.1182/blood.v66.3.577.577.

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Abstract Circulating lymphocytes leave the blood by binding to specialized high endothelial cells lining postcapillary venules in lymphoid organs or sites of chronic inflammations, migrating through the vessel wall into the surrounding tissue. The capacity of lymphocytes to recognize and bind to high endothelial venules (HEVs) is thus central to the overall process of lymphocyte traffic and recirculation. We show that viable human lymphocytes bind selectively to HEVs in frozen sections of normal human lymph nodes, thus defining a simple in vitro model for the study of human lymphocyte homing properties. Optimal conditions for the quantitative analysis of lymphocyte-HEV interaction are described. Furthermore, by using this assay, we demonstrate that the ability of human lymphocyte populations to bind to HEVs parallels their presumed migratory status in vivo. Thus, thymocytes and bone marrow cells, which are sessile in vivo, bind poorly to HEVs in comparison with mature circulating lymphocytes in peripheral blood or in peripheral lymphoid tissues. These results indicate that HEV-binding ability is a regulated property of mature lymphocytes and, as demonstrated previously in animal models, probably plays a fundamental role in controlling lymphocyte traffic in humans. The in vitro model of lymphocyte-HEV interaction thus provides a unique means to assay the migratory properties of normal and neoplastic human lymphocyte subsets, to analyze the role of lymphocyte traffic mechanisms in normal and pathologic inflammatory reactions, and to define some of the molecular mechanisms responsible for the control of lymphocyte migration and positioning in humans.

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Jalkanen, ST, and EC Butcher. "In vitro analysis of the homing properties of human lymphocytes: developmental regulation of functional receptors for high endothelial venules." Blood 66, no. 3 (September 1, 1985): 577–82. http://dx.doi.org/10.1182/blood.v66.3.577.bloodjournal663577.

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Circulating lymphocytes leave the blood by binding to specialized high endothelial cells lining postcapillary venules in lymphoid organs or sites of chronic inflammations, migrating through the vessel wall into the surrounding tissue. The capacity of lymphocytes to recognize and bind to high endothelial venules (HEVs) is thus central to the overall process of lymphocyte traffic and recirculation. We show that viable human lymphocytes bind selectively to HEVs in frozen sections of normal human lymph nodes, thus defining a simple in vitro model for the study of human lymphocyte homing properties. Optimal conditions for the quantitative analysis of lymphocyte-HEV interaction are described. Furthermore, by using this assay, we demonstrate that the ability of human lymphocyte populations to bind to HEVs parallels their presumed migratory status in vivo. Thus, thymocytes and bone marrow cells, which are sessile in vivo, bind poorly to HEVs in comparison with mature circulating lymphocytes in peripheral blood or in peripheral lymphoid tissues. These results indicate that HEV-binding ability is a regulated property of mature lymphocytes and, as demonstrated previously in animal models, probably plays a fundamental role in controlling lymphocyte traffic in humans. The in vitro model of lymphocyte-HEV interaction thus provides a unique means to assay the migratory properties of normal and neoplastic human lymphocyte subsets, to analyze the role of lymphocyte traffic mechanisms in normal and pathologic inflammatory reactions, and to define some of the molecular mechanisms responsible for the control of lymphocyte migration and positioning in humans.

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Landesberg, Regina, and Richard A. Insel. "Autologous mixed lymphocyte reaction in human neonatal lymphocytes." Human Immunology 24, no. 4 (April 1989): 231–38. http://dx.doi.org/10.1016/0198-8859(89)90017-7.

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Li, Lijin, Sharon M. Dial, Monika Schmelz, Margaret A. Rennels, and Neil M. Ampel. "Cellular Immune Suppressor Activity Resides in Lymphocyte Cell Clusters Adjacent to Granulomata in Human Coccidioidomycosis." Infection and Immunity 73, no. 7 (July 2005): 3923–28. http://dx.doi.org/10.1128/iai.73.7.3923-3928.2005.

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ABSTRACT The in situ immunologic response in human coccidioidomycosis remains undefined. To explore this further, pulmonary necrotizing coccidioidal granulomata were examined using immunohistochemical staining for lymphocyte subsets and for the cytokines interleukin-10 (IL-10) and gamma interferon (IFN-γ). Discrete perigranulomatous lymphocytic clusters were seen in eight of nine tissues examined. In these tissues, T lymphocytes (CD3+) significantly outnumbered B lymphocytes (CD20+) in the mantle area of the granulomata (P = 0.028), whereas the clusters were composed of roughly equal numbers of T and B lymphocytes. While the number of cells in the mantle expressing IL-10 was similar to those in the perigranulomatous clusters, there were significantly more cells expressing IFN-γ in the mantle than in the clusters (P = 0.037). Confocal microscopy revealed that CD4+ T lymphocytes and B lymphocytes are associated with IL-10 production. CD4+CD25+ T lymphocytes were identified in the perigranulomatous clusters but were not associated with IL-10 production. This is the first report noting perigranulomatous lymphocyte clusters and IL-10 in association with human coccidioidal granulomata and suggests that down-regulation of the cellular immune response is occurring within coccidioidal granulomata.

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Park, Suk W., Walter Royal, Richard D. Semba, Gordon W. Wiegand, and Diane E. Griffin. "Expression of Adhesion Molecules and CD28 on T Lymphocytes during Human Immunodeficiency Virus Infection." Clinical Diagnostic Laboratory Immunology 5, no. 4 (July 1, 1998): 583–87. http://dx.doi.org/10.1128/cdli.5.4.583-587.1998.

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ABSTRACT Adhesion molecules, which play a major role in lymphocyte circulation, have not been well characterized in human immunodeficiency virus (HIV) infection. T-lymphocyte populations, including CD3, CD4, CD28, and adhesion molecules (L selectin, LFA-1, VLA-4, and ICAM-1) were measured by flow cytometry in a cross-sectional study of 100 HIV-infected and 49 HIV-seronegative adults. HIV-infected adults had lower numbers of CD3+ lymphocytes expressing L selectin (P < 0.0001) and VLA-4 (P < 0.01) and higher numbers of CD3+ lymphocytes expressing LFA-1bright (P < 0.002) than did HIV-negative adults. By CD4+-lymphocyte count category (>500, 200 to 500, or <200 cells/μl), HIV-infected adults with more advanced disease had lower percentages of CD3+ lymphocytes expressing L selectin and VLA-4 and higher percentages of CD3+ lymphocytes expressing LFA-1. The percentages of CD3+ CD28+ lymphocytes and of CD3+L selectin+ lymphocytes were positively correlated (Spearman coefficient = 0.86; P < 0.0001), and the percentage of CD3+ CD28+ lymphocytes and the CD3+ LFA-1bright lymphocyte/CD3+LFA-1dim lymphocyte ratio were negatively correlated (Spearman coefficient = −0.92; P <0.00001). The results of this study suggest that HIV infection is associated with altered expression of adhesion molecules.

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Wu, N. W., S. Jalkanen, P. R. Streeter, and E. C. Butcher. "Evolutionary conservation of tissue-specific lymphocyte-endothelial cell recognition mechanisms involved in lymphocyte homing." Journal of Cell Biology 107, no. 5 (November 1, 1988): 1845–51. http://dx.doi.org/10.1083/jcb.107.5.1845.

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Tissue-specific interactions with specialized high endothelial venules (HEV) direct the homing of lymphocytes from the blood into peripheral lymph nodes, mucosal lymphoid organs, and tissue sites of chronic inflammation. These interactions have been demonstrated in all mammalian species examined and thus appear highly conserved. To assess the degree of evolutionary divergence in lymphocyte-HEV recognition mechanisms, we have studied the ability of lymphocytes to interact with HEV across species barriers. By using an in vitro assay of lymphocyte binding to HEV in frozen sections of lymphoid tissues, we confirm that mouse, guinea pig, and human lymphocytes bind to xenogeneic as well as homologous HEV. In addition, we show that mouse and human lymphoid cell lines that bind selectively to either peripheral lymph node or mucosal vessels (Peyer's patches, appendix) in homologous lymphoid tissues exhibit the same organ specificity in binding to xenogeneic HEV. Furthermore, monoclonal antibodies that recognize lymphocyte "homing receptors" and block homologous lymphocyte binding to peripheral lymph node or to mucosal HEV, also inhibit lymphocyte interactions with xenogeneic HEV in a tissue-specific fashion. Similarly, anti-HEV antibodies against organ-specific mouse high endothelial cell "addressins" involved in lymphocyte homing to peripheral lymph node or mucosal lymphoid organs, not only block the adhesion of mouse lymphocytes but also of human lymphocytes to target mouse HEV. The results illustrate a remarkable degree of functional conservation of elements mediating these cell-cell recognition events involved in organ-specific lymphocyte homing.

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Moriguchi, S., J. C. Jacksont, and R. R. Watson. "Effects of Retinoids on Human Lymphocyte Functions in vitro." Human Toxicology 4, no. 4 (July 1985): 365–78. http://dx.doi.org/10.1177/096032718500400402.

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1 E-Rosette formation in vitro, lymphocyte mitogenesis and natural killer (NK) activity of human blood lymphocytes were strongly inhibited by high concentration (10 -4 M) of retinol or retinal. Other retinoids at 10-4 M (retinoic acid and 13-cis-retinoic acid) and lower concentrations (10-7 or 10-9 M) of retinol, retinal and carotenes also inhibited E-rosette formation. 2 Lymphocyte transformation responses induced by concanavalin A (Con A) or pokeweed mitogen (PWM) were also inhibited while NK activity was not affected. 3 There was a remarkable depression of the total number of viable lymphocytes after incubation with retinol or retinal 10-4 M. However, other retinoids, 10-7 and 10-9 M of retinol and retinal and carotenes did not show marked decrease of lymphocyte number or viability even after prolonged incubation (48 h). 4 The mechanism of inhibition by retinol or retinal (10-4 M) is due in part to the decrease of viable lymphocytes. It is unclear how other retinoids, carotenes and lower concentrations (10-7 or 10-9 M) of retinol or retinal inhibit E-rosette formation or lymphocyte transformation.

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Sun, Anyuan, Haiming Wei, Rui Sun, Weihua Xiao, Yongguang Yang, and Zhigang Tian. "Human Interleukin-15 Improves Engraftment of Human T Cells in NOD-SCID Mice." Clinical and Vaccine Immunology 13, no. 2 (February 2006): 227–34. http://dx.doi.org/10.1128/cvi.13.2.227-234.2006.

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ABSTRACT Human nonobese diabetic-severe combined immune deficiency (NOD-SCID) mouse chimeras have been widely used as an in vivo model to assess human immune function. However, only a small fraction of transferred human T lymphocytes can be detected in human peripheral blood lymphocyte (huPBL)-NOD-SCID chimeras. To improve the reconstitution of human T lymphocytes in NOD-SCID mice, the use of recombinant human interleukin-15 (rhIL-15) as a stimulator of human lymphocytes was explored. Administration of rhIL-15 after transplantation of huPBLs into NOD-SCID mice increased reconstitution of human T lymphocytes in a dose-dependent manner, with an optimal dosage of 1 μg/mouse. The number of human T lymphocytes (HLA-ABC+ CD3+) in the lymphoid organs or tissue of rhIL-15-treated huPBL-NOD-SCID mice increased 11- to 80-fold, and phytohemagglutinin-induced T-lymphocyte proliferation and cytokine production were significantly enhanced. Additionally, although mature human cells have not been thought to enter the murine thymus, human T lymphocytes were detected in the huPBL-NOD-SCID thymus after rhIL-15 treatment. Thus, rhIL-15 can be used to optimize long-term peripheral T-cell engraftment in these human-mouse chimeras and may also be useful in clinical treatment of T-cell deficiencies.

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Spain, B. A., D. M. Soliman, R. A. Sidner, and H. L. Twigg. "Enhanced proliferation and IL-2 secretion by lung lymphocytes from HIV-infected subjects." American Journal of Physiology-Lung Cellular and Molecular Physiology 269, no. 4 (October 1, 1995): L498—L506. http://dx.doi.org/10.1152/ajplung.1995.269.4.l498.

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Human immunodeficiency virus (HIV)-positive patients frequently develop a CD3+/CD8+ cytotoxic T cell lymphocytic alveolitis. This could occur through in situ expansion of lung lymphocytes. We evaluated lung and blood lymphocyte proliferation in asymptomatic HIV-infected individuals by measuring spontaneous and cytokine-induced tritiated thymidine incorporation. Interleukin (IL)-2 and IL-4 secretion was determined with the use of enzyme-linked immunosorbent assay, Western blotting, and immunoprecipitation techniques. Spontaneous proliferation by lung lymphocytes from HIV-positive patients was significantly greater than that of normal volunteers. Proliferation was confined to the CD8+ lymphocyte subset. Over time, spontaneous proliferation declined unless autologous alveolar macrophages (AM) were added, suggesting AM were providing additional stimulatory signals to lung lymphocytes. Lung and blood lymphocytes proliferated in response to IL-2 but not IL-4. Lymphocytes in HIV-infected lung spontaneously produced and secreted more IL-2 than either normal lung lymphocytes or autologous blood lymphocytes. IL-4 production was not detectable in either group. These findings support the hypothesis that lymphocytic alveolitis in asymptomatic HIV-positive patients results from IL-2-dependent in situ proliferation of CD3+/CD8+ cytotoxic T cells.

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Dissertations / Theses on the topic "Human lymphocyte"

1

Paterson, Alastair Glen. "Lymphocyte function in human breast cancer." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/20091.

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DiSanto, James Philip. "Molecular events in human T cell activation : CD4, CD8 and the human Lyt-3 molecules /." Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=745024391&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Boroujerdnia, Mehri Ghafourian. "Investigation of lymphocyte populations in human endometrium." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307830.

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Krajewski, Andrew Stephen. "Human T-lymphocyte colony formation in vitro." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/24047.

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Nowak, Monika. "Human herpesvirus-6-induced cytokines and lymphocyte anergy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0009/NQ28364.pdf.

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Arkwright, P. D. "Effects of the human trophoblast on lymphocyte proliferation." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236250.

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Gargett, Caroline Eve, and mikewood@deakin edu au. "Studies of the human lymphocyte P2Z receptor and its activation of phospholipase D." Deakin University, 1997. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20060727.144101.

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Extracellular adenosine 5′-triphosphate (ATP) is an agonist for the P2Z receptor of human leukaemic lymphocytes and opens a Ca ²⁺-selective ion channel, which also conducts Ba²⁺, Sr²⁺ and the small fluorescent dye, ethidium⁺. A wide range of receptor agonists, many of which raise cytosolic [Ca²⁺] activate phospholipase D (PLD). In the present study, it was shown that both ATP and 3′-O-(4-benzoylbenzoyl)-ATP (BzATP) stimulated PLD activity in a concentration-dependent manner, and the inhibitory effects of suramin, oxidised ATP, extracellular Na⁺ and Mg²⁺ suggested that the effect of these agonists is mediated by P2Z receptors. The role of divalent cations in ATP-stimulated PLD activity was investigated. Several agonists (eg ATP, thapsigargin, ionomycin) stimulated a rise in cytosolic [Ca²⁺] in human lymphocytes, but only ATP and ionomycin stimulated PLD activity. When Ca²⁺ influx was prevented by EGTA, the majority of ATP-stimulated and all of ionomycin-stimulated PLD activity was inhibited. Preloading cells with the Ca²⁺ chelator, BAPTA, reduced cytosolic [Ca²⁺] and, paradoxically, ATP-stimulated PLD activity was potentiated. ATP-stimulated PLD activity was supported by both Ba²⁺ and Sr²⁺ when they were substituted for extracellular Ca²⁺. Furthermore, both ATP-stimulated PLD activity and ATP-stimulated ¹³³Ba²⁺ influx showed a linear dependence on extracellular [Ba²⁺]. Thus it was concluded that ATP stimulated PLD activity in direct proportion to the influx of divalent cations through the P2Z ion channel and this PLD activity was insensitive to changes in bulk cytosolic [Ca²⁺]. The calmodulin (Ca²⁺/CaM) inhibitor, trifluoperazine (TFP) inhibited ionomycin- and ATP-stimulated PLD activity and ATP-stimulated apoptosis, but had no effect on PLD activity already activated by ATP. However, TFP inhibited ATP-stimulated Ca²⁺, Ba²⁺ and ethidium⁺ fluxes, at concentrations below those which inhibit Ca²⁺/CaM, suggesting that TFP inhibits the P2Z receptor. Similarly, the isoquinolinesulphonamide, KN-62, a selective inhibitor of Ca²⁺/CaM-dependent protein kinase II (CaMKII), also prevented ATP-stimulated apoptosis, but had no effect on pre-activated PLD. In addition, KN-62, and an analogue, KN-04, which has no effect on CaMKII, potently inhibited ATP-stimulated Ba²⁺ influx (IC₅₀ 12.7 ± 1.5 and 17.3 ± 2.7 nM, respectively), ATP-stimulated ethidium⁺ uptake (IC₅₀ 13.1 ± 2.6 and 37.2 ± 8.9 nM, respectively), ATP-stimulated phospholipase D activity (50% inhibition 5.9 ± 1.2 and 9.7 ± 2.8 nM, respectively) and ATP-induced shedding of the surface adhesion molecule, L-selectin (IC₅₀ 31.5 ± 4.5 and 78.7 ± 10.8 nM, respectively). They did not inhibit phorbol ester- or ionomycin-stimulated PLD activity or phorbol ester-induced L-selectin shedding. Neither KN-62 nor KN-04 (both 500 nM) have any effect on UTP-stimulated Ca²⁺ transients in fura-2-loaded human neutrophils, a response which is mediated by the P2Y₂ receptor, neither did they inhibit ATP-stimulated contractile responses mediated by the P2X₁ receptor of guinea pig urinary bladder. Thus, KN-62 and KN-04 are almost equipotent as P2Z inhibitors with IC₅₀s in the nanomolar, indicating that their actions cannot be due to CaMKII inhibition, but rather that they are potent and direct inhibitors of the P2Z receptor. Extracellular ATP-induced shedding of L-selectin from lymphocytes into the medium is a Ca²⁺-independent response. L-selectin is either cleaved by a metalloproteinase or a PLD with specificity for glycosylphosphatidylinositol (GPI). The novel hydroxamic acid-based zinc chelator, Ro-31-9790 blocks ATP-induced L-selectin shedding, but was without effect on ATP-induced Ba²⁺ influx or ATP-stimulated PLD activity. Furthermore, another zinc chelator, 1,10-phenanthroline, an inhibitor of a GPI-PLD, potentiated rather than inhibited ATP-stimulated PLD activity, suggesting that ATP-induced L-selectin shedding and ATP-stimulated PLD activity are independent of each other. Although extracellular ATP is the natural ligand for the lymphocyte P2Z receptor, it is less potent than BzATP in stimulating Ba²⁺ influx. Concentration-response curves for BzATP- and ATP-stimulated ethidium⁺ influx gave EC₅₀s 15.4 ± 1.4 µM and 85.6 ± 8.8 µM, respectively. The maximal response to ATP was only 69.8 ± 1.9% of that for BzATP. Hill coefficients were 3.17 ± 0.24 and 2.09 ± 0.45 for BzATP and ATP respectively, suggesting greater positive cooperativity for BzATP than for ATP in opening the P2Z-operated ion channel. A rank order of agonist potency of BzATP > ATP = 2MeSATP > ATPγS was observed for agonist-stimulated ethidium⁺ influx, while maximal influxes followed a rank order of BzATP > ATP > 2MeSATP > ATPγS. When ATP (300 -1000 µM) was added simultaneously with 30 µM BzATP (EC₉₀), it reduced both ethidium⁺ and Ba²⁺ fluxes by 30 - 40% relative to values observed with BzATP alone. KN-62, previously shown to be a specific inhibitor of the lymphocyte P2Z receptor, was a less potent antagonist of BzATP-induced fluxes than ATP, when maximal concentrations of both agonists (50 and 500 µM respectively) were used. However, when BzATP (18 µM) was used at a concentration equiactive with a maximally effective ATP concentration, KN-62 showed the same inhibitory potency for both agonists. The ecto-ATPase antagonist, ARL-67156, inhibited both ATP- and BzATP-stimulated Ba²⁺ influx, suggesting that the lower efficacy of ATP compared with BzATP was not due to preferential hydrolysis of ATP. Thus, the natural ligand, ATP, is a partial agonist for the P2Z receptor while BzATP is a full agonist. Moreover the competitive studies show that only a single class of P2-receptor (P2Z class) is expressed on human leukaemic lymphocytes. Both ATP- and BzATP-stimulated PLD activity were significantly inhibited (P < 0.05) when cells were suspended in iso-osmotic choline Cl medium. Choline⁺ was found to be a permeant for the P2Z ion channel, since ATP induced a large uptake of [¹⁴C]choline⁺ (60 to 150 µmol/ml intracellular water) during a 5 min incubation, which remained in the cells for several hours, and ATP was used to load cells with these levels of choline⁺. Intracellular choline⁺ inhibited ATP-, BzATP-, PMA- and ionomycin-stimulated PLD activity. Brief exposure of lymphocytes to ATP increased the subsequent basal rate of ethidium⁺ uptake, and this was prevented by intracellular choline⁺. It is proposed that P2Z-mediated Ca²⁺ influx in lymphocytes activates PLD leading to significantly changes of the phospholipid composition of the plasma membrane, which subsequently produces a permeability lesion, which in turn contributes to cell death.

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Dessureault, Sophie. "Lymphocyte responses to B7-1 expressing human cancer cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq41014.pdf.

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Noble, Peter Richard. "CD4 T lymphocyte responses to human papillomavirus type 16." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314205.

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Dunne, Jenny. "Human T lymphocyte cell surface antigens and their genes." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281609.

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Books on the topic "Human lymphocyte"

1

Carlos, Rodríguez-Gallego, and Arnaiz-Villena Antonio, eds. Human T-lymphocyte activation deficiencies. Austin, TX: R.G. Landes, 1994.

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Finney, Michael. A study in the molecular basis of human B lymphocyte activation. Birmingham: University of Birmingham, 1991.

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Collins, Clive Dennis. The adult human liver as a site of extrathymic T lymphocyte differentiation. Dublin: University College Dublin, 1997.

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Hurn, A. S. Modelling the lifespan of human lymphocyte subsets: Maximum likelihood estimation by embedded simulation. Glasgow: Glasgow University Department of Political Economy, 1994.

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M, Optiz John, Paul Natalie W, and March of Dimes Birth Defects Foundation., eds. Blastogenesis: Normal and abormal : proceedings of the Second International Workshop on Fetal Genetic Pathology, held at Big Sky, Montana, 12-16 October 1991. New York: Wiley-Liss, 1993.

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Tumor-infiltrating lymphocytes in human malignancies. Austin: R.G. Landes Co., 1993.

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Kamal, Mohammed. Role of CD72 on human lymphocytes. Birmingham: University of Birmingham, 1993.

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Carton, Janet. Heterogeneity of Human Intestinal T Lymphocytes. Dublin: University College Dublin, 1998.

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Oldstone, Michael B. A., ed. Cytotoxic T-Lymphocytes in Human Viral and Malaria Infections. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78530-6.

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Abdul-Hassan, K. S. M. Infidelity of DNA repair in selenium treated human lymphocytes. Manchester: UMIST, 1996.

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Book chapters on the topic "Human lymphocyte"

1

Stein, H. "Lymphocyte differentiation." In Human Lymphoma: Clinical Implications of the REAL Classification, 9–12. London: Springer London, 1999. http://dx.doi.org/10.1007/978-1-4471-0857-3_2.

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Milanese, Claudio, Robert F. Siliciano, Neil E. Richardson, Hsiu-Ching Chang, Andres Alcover, and Ellis L. Reinherz. "Human T Lymphocyte Activation." In Mechanisms of Lymphocyte Activation and Immune Regulation, 59–68. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5323-2_7.

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Olive, D., D. Charmot, P. Dubreuil, A. Tounkara, M. Ragueneau, C. Mawas, and P. Mannoni. "Human Lymphocyte Functional Antigens." In Human T Cell Clones, 173–85. Totowa, NJ: Humana Press, 1985. http://dx.doi.org/10.1007/978-1-4612-4998-6_16.

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Iwamoto, Ryo, Eisuke Mekada, Thomas G. Hofmann, Eva Krieghoff-Henning, Masaaki Kobayashi, Ken Takamatsu, Jennifer Defren, et al. "Human Mucosal Lymphocyte Antigen 1." In Encyclopedia of Signaling Molecules, 886. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100631.

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Söder, Olof. "Isolation of Lymphocyte Activating Factors from Human Milk." In Human Lactation 3, 384. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4899-0837-7_53.

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Gazzolo, L., M. Duc Dodon, A. Gessain, M. Robert-Guroff, and G. de-The. "RNA Viruses and Lymphocyte Immune Functions." In International Symposium: Retroviruses and Human Pathology, 353–61. Totowa, NJ: Humana Press, 1985. http://dx.doi.org/10.1007/978-1-4612-5008-1_31.

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Vuadens, Françoise, David Crettaz, Amalio Telenti, Manfredo Quadroni, Michel A. Duchosal, Philippe Schneider, and Jean-Daniel Tissot. "Proteomic Studies of Human Lymphocytes: New Insights into HIV Lymphocyte Infection?" In Biomedical Applications of Proteomics, 245–62. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2004. http://dx.doi.org/10.1002/3527601562.ch14.

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Berrih-Aknin, S., D. Safar, and S. Cohen-Kaminsky. "Analysis of Lymphocyte Phenotype in Human Thymomas." In Advances in Experimental Medicine and Biology, 369–74. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5535-9_55.

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Coutre, Steven, Steven K. H. Foung, and Edgar G. Engleman. "Human T-Lymphocyte Subsets and T-T Hybridomas." In Human Hybridomas and Monoclonal Antibodies, 311–21. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-4949-5_18.

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Wu, Rong, Nicholas Coleman, Geoffrey Higgins, Esther Choolun, and Margaret A. Stanley. "Lymphocyte-Mediated Natural Cytotoxicity to HPV16 Infected Cervical Keratinocytes." In Immunology of Human Papillomaviruses, 255–58. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2449-6_40.

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Conference papers on the topic "Human lymphocyte"

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Filippi, J. F., D. Arnoux, N. Tubiana, B. Boutière, F. Le Caär, J. Sampol, Lab Hématol, Pr J. Sampol, and Pr Y. Carcassonne. "PLASMINOGEN ACTIVATOR ACTIVITY OF NORMAL AND MALIGNANT MONONUCLEAR HUMAN CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643167.

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Plasminogen activators (PA) are thought to play a role in the invasive and metastatic properties of many types of cancer cells. Though, discrepancies in correlations between fibrinolytic activity and metastatic potential of malignant cells have been described.In this study, we evaluated both tissue type (tPA) and urokinase type (UK) cellular PA activities in different mononuclear cell types : normal T and B human peripheral lymphocytes, B cells from patients with chronic lymphocytic leukemia (CLL), human blood monocytes, alveolar macrophages, U 937, RAJI and JM cell 1ines.Mononuclear cells were isolated by Ficoll-hypaque gradients and monocytes by plastic adhesion. T and B cells were separated by a rosetting technique using sheep red blood cells. Cellular extracts were prepared by 0.5 % Triton X 100 buffer treatment followed by sonication and centrifugation 10 ' at 2000 g. PA assays were performed on the supernatants.UK-type PA was evaluated by a liquid-phase assay in presence of human plasminogen (Kabi) and chromogenic substrate S 2251 (Kabi).tPA was determinated using a solid-phase fibrin activity assay which involves an affinity separation step and thus allows selective detection of tPA.In both cases, results were reported in international units by reference to standard curves of UK (Choay) or tPA (Kabi).In all cell types tested, PA detected was essentially urokinase-type. Highest PA activity was found in U 937 cells (0.7 IU/5×l06 cells). In normal blood lymphocytes, mean PA activity was 0.08 IU/5×l06 cells. Examination of lymphocytes from patients with CLL revealed a marked decrease in UK activity as compared to normals (< 0.01 IU/5×106 cells in more than 50 % cases).The function of PA in normal lymphocyte physiology and the potential pathogenic role of diminished PA in CLL lymphocytes remains to be investigated.

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Mohapatra, Subrajeet, Dipti Patra, Sunil Kumar, and Sanghamitra Satpathi. "Kernel Induced Rough c-means clustering for lymphocyte image segmentation." In 2012 4th International Conference on Intelligent Human Computer Interaction (IHCI). IEEE, 2012. http://dx.doi.org/10.1109/ihci.2012.6481865.

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Aydar, S., S. Alataş, L. Numanoğlu, and A. Sönmezdağ. "EFFECT OF ORAL ANTICOAGULANTS ON STABLE ROSETTE FORMATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643271.

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Human peripheral blood T lymphacytes when cultered in the presence of mitogen Phytohemogglutinin (PHA) acquire the capacity to form E rosettes with sheep erythrocytes that are resistant to incubation at 37° C. Whereas human thymus lymphocytes form 37° C stable E rosettes. On the other hand, it is shown that the use of anticoagulants can prevent cancer metastases which brings forth the importance of explaining the relationship between the lymphocyte functions and anticoagulant action mecha-nismus. In order to investigate this relationship, we did a group af experiments with lymphocytes of normal children and of children with severe burn wounds. Peripheral blood lymphocytes were seperated by “Lymphoprep” centrifugation technique. The lymphocytes of normal children and patients with burn were divided in two groups: A-Activated lymphocytes: 1×106 /ml lymphocytes were cultured and activated by PHAfor 48 hours at 37° C in RPMI 1640. B-Non activated lymphocytes were in culture witout PHA. 1×10™6 M/ml warfarin sulfate was added to some of the cultures of each group prior to the culture conditions. At the end of the 48 hour incubation, heat stable rosette formation was determined by the method of Wauve and co-workers. Significantly elevated levels of heat stable rosette forming cells were found in the PHA activated culture treated with warfarin sulfate in normals and patients with burn. Although the blastic transformation of T lymphocytes was found to be depressed, heat stable rosette formation of warfarin sulfate treated lymphocytes abtained from burn patients was observed to be significantly elevated. It is concluded that warfarin sulfate increases the activity of T lymphocytes by interfering with the resynthesis of heai stable E receptors.

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Grimaldi, Domenico, Francesco Lamonaca, and Alfonso Nastro. "Blind correction of human lymphocyte images by optimal thresholding in UWT domain." In 2010 IEEE International Workshop on Medical Measurements and Applications (MeMeA). IEEE, 2010. http://dx.doi.org/10.1109/memea.2010.5480200.

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Grimaldi, Domenico, and Francesco Lamonaca. "Surface Measurement of the Human Lymphocyte Micro-Nucleus in Image Affected by Alterations." In 2007 IEEE International Workshop on Medical Measurement and Applications. IEEE, 2007. http://dx.doi.org/10.1109/memea.2007.4285171.

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Schreiber, A. B., R. Gillette, and M. E. Hrinda. "IN VITRO IMMUNE PARAMETERS OF MONOCLATEH, A, MONOCLONAL ANTIBODY PURIFIED HUMAN PLASMA FACTOR VIII:C THERAPEUTIC PREPARATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644051.

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MonoclateR is a highly purified human factor VIII:C preparation obtained by immunoaffinity chromatography of plasma cryoprecipitat followed by chromatography on aminohexyl sepharose. The resulting product is devoid of alloantigens, can be stabilized in the absence of extraneous human proteins and has a specific activity higher than 3000 U/mg.To ascertain product integrity, we set out to compare MonoclateR preparations with either unfractionated human plasma, cryoprecipitateor commercially available lyophilized antihemophilia factor (AHF) preparations by Western blots. As probes, we utilized a series of monoclonal antibodies to defined factor VIII:C epitopes. The MonoclateR VIII:C chain composition appeared indistinguishable from that in the native state of in commercial, clinically useful preparations.Patients with hemophilia are often afflicted with an impairment of cell-mediated immunity, when treated repeatedly with plasma cryoprecipitate preparations. Those preparations, containing at best 0.2% factor VIII:C in protein content, were found in our hands to dramatically inhibit both human mixed lymphocyte reactions and the phytohemagglutinin induced human lymphocyte mitogenesis. We obtained 50% inhibition at about 1 mg/ml protein concentration. These effects were not due to cytotoxicity nor related to procoagulant potency.MonoclateR, in contrast, was totally devoid of immunosuppressive activity at all concentrations tested. This in vitro finding may be related to clinical observation of corrections in immune impairment in adult hemophiliacs treated with MonoclateR. With this immunological profile, MonoclateR represents in our opinion, a promising novel treatment modality for hemophilia A.

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Zhang, Lu, Xin Zhao, Xingyu Chen, Kaixing Li, Yunfei Xing, Wei Chen, Hong Zhao, Zhuangde Jiang, Li Yuan, and Nianling Yao. "Spatial scattering specificities study on label free clinical lymphocyte cells of human peripheral blood." In 2015 IEEE 10th Conference on Industrial Electronics and Applications (ICIEA). IEEE, 2015. http://dx.doi.org/10.1109/iciea.2015.7334387.

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Dolbniak, Marzena, Joanna Zyla, Sylwia Kabacik, Grainne Manning, Christophe Badie, Ghazi Alsbeih, and Joanna Polanska. "Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?" In International Conference on Bioinformatics Models, Methods and Algorithms. SCITEPRESS - Science and and Technology Publications, 2015. http://dx.doi.org/10.5220/0005286102430250.

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Bolognani, Lorenzo, Michele Costato, Marziale Milani, Monica Pegna, Maria L. Villa, and Giancarlo Zonca. "Low-level laser light long-term effects on human lymphocyte proliferation and partially inactivated enzyme reactivation." In OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, edited by Michal Schwartz and Michael Belkin. SPIE, 1993. http://dx.doi.org/10.1117/12.148013.

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Grimaldi, Domenico, and Francesco Lamonaca. "Pre-processing of Image Affected by Contemporaneous Alterations for Surface Measurement of the Human Lymphocyte Micro-Nucleus." In 2007 4th IEEE Workshop on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications. IEEE, 2007. http://dx.doi.org/10.1109/idaacs.2007.4488440.

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Reports on the topic "Human lymphocyte"

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Gateva, Svetla, Gabriele Jovtchev, Alexander Stankov, Anna Dobreva, and Milka Mileva. Geraniol Inhibits the Genotoxic Effect of MNNG in Plant and Human Lymphocyte Test-systems. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, September 2019. http://dx.doi.org/10.7546/crabs.2019.09.08.

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Norman, A. Environmental damage in human lymphocytes: Final report, January 1, 1983-September 30, 1986. Office of Scientific and Technical Information (OSTI), January 1986. http://dx.doi.org/10.2172/5200148.

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Brooks, Stephen P. Can Labeled Human CD 34+ Lymphocytes be Used to Identify Sites of Angiogenesis Within Growing Tumors. Fort Belvoir, VA: Defense Technical Information Center, October 2002. http://dx.doi.org/10.21236/ada411739.

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Nelson, Marian R., Clark L. Gross, William J. Smith, and Susan A. Kelly. Determination of ATP Levels in Sulfur Mustard-Exposed Human Peripheral Blood Lymphocytes by a Chemiluminescent Assay. Fort Belvoir, VA: Defense Technical Information Center, January 2000. http://dx.doi.org/10.21236/ada390626.

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Swicord, Mays L. A Study of the Effects of High Power Pulsed 2450 MHz Microwaves, ELF modulated Microwaves, and ELF Fields on Human Lymphocytes and Selected Cell Lines. Fort Belvoir, VA: Defense Technical Information Center, January 1993. http://dx.doi.org/10.21236/ada269070.

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