Academic literature on the topic 'Human liver microsomes'
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Journal articles on the topic "Human liver microsomes"
Minoda, Yuko, and Evan D. Kharasch. "Halothane-dependent Lipid Peroxidation in Human Liver Microsomes Is Catalyzed by Cytochrome P4502A6 (CYP2A6)." Anesthesiology 95, no. 2 (August 1, 2001): 509–14. http://dx.doi.org/10.1097/00000542-200108000-00037.
Full textMyllynen, P., P. Pienimäki, H. Raunio, and K. Vähäkangas. "Microsomal metabolism of carbamazepine and oxcarbazepine in liver and placenta." Human & Experimental Toxicology 17, no. 12 (December 1998): 668–76. http://dx.doi.org/10.1177/096032719801701204.
Full textBarnes, T. S., M. D. Burke, and W. T. Melvin. "Differences in adult and foetal human cytochrome P-450 forms recognized by monoclonal antibodies with specificity for the P450III family." Biochemical Journal 260, no. 3 (June 15, 1989): 635–40. http://dx.doi.org/10.1042/bj2600635.
Full textGeorge, R., P. J. Davis, L. Luong, and M. J. Poznansky. "Cholesterol-mediated regulation of HMG-CoA reductase in microsomes from human skin fibroblasts and rat liver." Biochemistry and Cell Biology 68, no. 3 (March 1, 1990): 674–79. http://dx.doi.org/10.1139/o90-097.
Full textNguyen, Ngoc, Ngoc Cao, Thi Nguyen, Thien-Kim Le, Gun Cha, Soo-Keun Choi, Jae-Gu Pan, Soo-Jin Yeom, Hyung-Sik Kang, and Chul-Ho Yun. "Regioselective Hydroxylation of Phloretin, a Bioactive Compound from Apples, by Human Cytochrome P450 Enzymes." Pharmaceuticals 13, no. 11 (October 22, 2020): 330. http://dx.doi.org/10.3390/ph13110330.
Full textCourt, Michael H., Su X. Duan, Leah M. Hesse, Karthik Venkatakrishnan, and David J. Greenblatt. "Cytochrome P-450 2B6 Is Responsible for Interindividual Variability of Propofol Hydroxylation by Human Liver Microsomes." Anesthesiology 94, no. 1 (January 1, 2001): 110–19. http://dx.doi.org/10.1097/00000542-200101000-00021.
Full textMilewich, L., P. C. MacDonald, and B. R. Carr. "Activity of 17β-hydroxysteroid oxidoreductase in tissues of the human fetus." Journal of Endocrinology 123, no. 3 (December 1989): 509–18. http://dx.doi.org/10.1677/joe.0.1230509.
Full textWang, Li, Zhe Wang, Meng-ming Xia, Ying-ying Wang, Hai-yun Wang, and Guo-xin Hu. "Inhibitory effect of silybin on pharmacokinetics of imatinib in vivo and in vitro." Canadian Journal of Physiology and Pharmacology 92, no. 11 (November 2014): 961–64. http://dx.doi.org/10.1139/cjpp-2014-0260.
Full textSenler, T. I., W. L. Dean, L. F. Murray, and J. L. Wittliff. "Quantification of cytochrome P-450-dependent cyclohexane hydroxylase activity in normal and neoplastic reproductive tissues." Biochemical Journal 227, no. 2 (April 15, 1985): 379–87. http://dx.doi.org/10.1042/bj2270379.
Full textSvobodová, Martina, Markéta Martínková, Eva Frei, and Marie Stiborová. "Identification of human enzymes oxidizing a human metabolite of carcinogenic 2-nitroanisole, 2-nitrophenol. Evidence for its oxidative detoxification by human cytochromes P450." Collection of Czechoslovak Chemical Communications 75, no. 6 (2010): 703–19. http://dx.doi.org/10.1135/cccc2010023.
Full textDissertations / Theses on the topic "Human liver microsomes"
Emery, Maurice George. "Aspects of human CYP 2E1 regulation in health and disease /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7943.
Full textMcLure, James Alexander, and james mclure@flinders edu au. "Physicochemical determinants of the non-specific binding of drugs to human liver microsomes." Flinders University. Medicine, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081102.165952.
Full textSchjølberg, Tiril Helgesen. "In Vitro Synthesis of Metabolites of three Anabolic Androgenic Steroids, by Human Liver Microsomes." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for bioteknologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22910.
Full textMaley, Mary. "The role of individual forms of cytochrome P450 in drug metabolism in human liver microsomes." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU078654.
Full textAbu-Omar, Ghada M. "Drug interactions and metabolism of cyclosporin A and steroids by human liver microsomes in vitro." Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU545502.
Full textDowsley, Taylor Forbes. "CYP2E1-dependent bioactivation of 1,1-dichloroethylene to reactive intermediates in murine and human lung and liver microsomes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ38304.pdf.
Full textStrömqvist, Malin. "Development of quantitative methods for the determination of vemurafenib and its metabolites in human plasma." Thesis, Linköpings universitet, Kemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-110076.
Full textShepard, Dale Randall. "The Metabolism of Phenytoin by Human Liver Microsomes and Cytochrome P450s Expressed in Saccharomyces Cerevisiae and COS-1 Cells /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487931512618872.
Full textUwimana, Eric. "Probing the PCB metabolome: metabolism of chiral and non-chiral polychlorinated biphenyls to chiral hydroxylated metabolites in humans and rats." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6657.
Full textLarabi, Islam Amine. "Nouveaux produits de synthèse : analyse, consommation et métabolisme ; Applications cliniques et médicolégales Rapid and simultaneous screening of new psychoactive substances and conventional drugs of abuse. A comparative study of Biochip Array Technology versus LC-MS/MS in whole blood and urine Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances Validation of an UPLC-MS/MS method for the determination of sixteen synthetic cannabinoids in human hair. Application to document chronic use of JWH-122 following a non-fatal overdose Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review Prevalence of New Psychoactive Substances(NPS) and conventional drugs of abuse (DOA) in high risk populations from Paris(France) and its suburbs A cross sectional study by hair testing(2012–2017) Evaluation of drug abuse by hair analysis and self-reported use among MSM under PrEP: Results from a sub-study of the ANRS-IPERGAY trial. Hair testing for 3‑fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose Drug‐facilitated sexual assault (DFSA) involving 4‐methylethcathinone (4‐MEC),3,4‐Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis Metabolic Profiling of Deschloro-N-ethyl-ketamine (O-PCE) and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL029.
Full textThe aim of the present work was to develop two analytical approaches dedicated to the analysis of new psychoactive substances in different biological matrices (blood, urine and hair). The first approach is based on untargeted screening by both biochip array technology chemiluminescence assay and liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) and the second corresponds to a targeted screening by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). These two approaches were then applied in observational studies to assess the consumption of NPS in high risk populations (overdose, drug abuse, drug facilitated crimes) in clinical and forensic settings. The last part of the work was devoted to the development of a new analytical tool for LC-HRMS data processing which made it possible to study the metabolism of 9 NPS In vitro on human liver microsomes (HLM) and In vivo in biological samples from drug users. This approach has enabled the creation of HRMS spectral library containing 228 metabolites, some of which have been proposed as relevant markers of NPS exposure.This work has resulted on 10 scientific publications and allowed to initiate many multidisciplinary collaborations
Books on the topic "Human liver microsomes"
Nicotine C-oxidation by human liver microsomes: A major role for CYP2A6. Ottawa: National Library of Canada, 1996.
Find full textBarsoum, Rashad S. Schistosomiasis. Edited by Neil Sheerin. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0181_update_001.
Full textBook chapters on the topic "Human liver microsomes"
McManus, M. E., D. J. Birkett, W. M. Burgess, I. Stupans, J. A. Koenig, A. R. Boobis, D. S. Davies, P. J. Wirth, P. H. Grantham, and S. S. Thorgeirsson. "Flavin-Containing Monooxygenase Activity in Human Liver Microsomes." In Biological Reactive Intermediates III, 773–79. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5134-4_72.
Full textJia, Jia. "Cytochrome P450 Inhibition Assay Using Human Liver Microsomes." In Methods in Pharmacology and Toxicology, 91–105. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1542-3_6.
Full textYan, Zhengyin, and Gary W. Caldwell. "Evaluation of Cytochrome P450 Inhibition in Human Liver Microsomes." In Optimization in Drug Discovery, 231–44. Totowa, NJ: Humana Press, 2004. http://dx.doi.org/10.1385/1-59259-800-5:231.
Full textCoe, Kevin J., Judith Skaptason, and Tatiana Koudriakova. "Identification of Time-Dependent CYP Inhibitors Using Human Liver Microsomes (HLM)." In Methods in Pharmacology and Toxicology, 305–14. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-742-6_18.
Full textWu, Wu-Nan, and Linda A. McKown. "In Vitro Drug Metabolite Profiling Using Hepatic S9 and Human Liver Microsomes." In Optimization in Drug Discovery, 163–84. Totowa, NJ: Humana Press, 2004. http://dx.doi.org/10.1385/1-59259-800-5:163.
Full textChristians, U., H. M. Schiebel, J. Bleck, and K. Fr Sewing. "Elucidation of the Metabolic Pathways of Cyclosporine in Vitro by Human Liver Microsomes." In Drugs and the Liver: High Risk Patients and Transplantation, 165–70. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1994-8_27.
Full textBenga, Gh. "Molecular Composition, Fluidity of Membranes and Functional Properties of Human Liver Mitochondria and Microsomes." In Molecular Basis of Membrane-Associated Diseases, 285–302. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74415-0_24.
Full textHörnsten, Lena, Johan Bylund, and Ernst H. Oliw. "Bisallylic Hydroxylation of Linoleic and Arachidonic Acids by Adult and Fetal Human Liver Microsomes and a Comparison with Human Recombinant Cytochromes P450." In Advances in Experimental Medicine and Biology, 123–26. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1810-9_25.
Full textCaldwell, Gary W., and Zhengyin Yan. "Rapidly Distinguishing Reversible and Time-Dependent CYP450 Inhibition Using Human Liver Microsomes, Co-incubation, and Continuous Fluorometric Kinetic Analyses." In Methods in Pharmacology and Toxicology, 281–303. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-742-6_17.
Full textAhmed, S. Sohail, Kimberly L. Napoli, and Henry W. Strobel. "Oxygen Radical Formation Due to the Effect of Varying Hydrogen Ion Concentrations on Cytochrome P450-Catalyzed Cyclosporine Metabolism in Rat and Human Liver Microsomes." In Advances in Experimental Medicine and Biology, 135–39. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4757-9480-9_19.
Full textConference papers on the topic "Human liver microsomes"
Widdison, Wayne C., Sharon Wilhelm, Karen Veale, Yelena Kovtun, Hans Erickson, Charlene Audette, Barbara Leeca, Gregory Jones, and Ravi Chari. "Abstract 2668: Detoxification of metabolites from antibody-maytansinoid conjugates by human liver microsomes." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2668.
Full textLiu, Xing, Albert DeJesus, Dana Vardeman, Zhisong Cao, and Beppino Giovanella. "Abstract 4337:In vitrobiotransformation of and inhibitory effects of CZ48 in human liver microsomes." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4337.
Full textGrafakou, M. E., C. Barda, E. Skaltsa, and J. Heilmann. "Identification of parthenolide metabolites in human liver microsomes by LC-Q-TOF-MS/MS." In GA – 69th Annual Meeting 2021, Virtual conference. Georg Thieme Verlag, 2021. http://dx.doi.org/10.1055/s-0041-1736874.
Full textOuyang, Hui, Huiping Liao, Junmao Li, Mingzhen He, Yan Li, Xiaoyong Rao, Qi Wang, Shilin Yang, Zhifeng Li, and Yulin Feng. "COMPARATIVE METABOLISM CHARACTERISTICS RESEARCH OF TETRAHYDROPALMATINE IN FIVE SPECIES (DOG, HUMAN, MICE, MONKEY, AND RAT) LIVER MICROSOMES BY UHPLC/ESI-QTOF-MS/MS." In 2016 International Conference on Biotechnology and Medical Science. WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789813145870_0023.
Full textReports on the topic "Human liver microsomes"
Abou-Donia, M. B., and A. W. Abu-Quare. In Vitro Metabolism of Pyridostigmine Bromide (PB), DEET and Permethrin, Alone and in Combination by Human Plasma and Liver Microsomes. Fort Belvoir, VA: Defense Technical Information Center, March 2001. http://dx.doi.org/10.21236/ada402080.
Full textCasabar, Richard C., Andrew D. Wallace, Ernest Hodgson, and Randy L. Rose. Metabolism of Endosulfan-Alpha by Human Liver Microsomes and its Utility as a Simultaneous In Vitro Probe for CYP2B6 and CYP3A4. Fort Belvoir, VA: Defense Technical Information Center, March 2006. http://dx.doi.org/10.21236/ada445178.
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