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1
Kong, Yu-Chien. "Ability, education choice and life cycle earnings." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/2548.
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This dissertation consists of two chapters. In the first chapter, I explain changes in the life-cycle earnings profile for different birth cohorts. The second chapter assesses the quantitative importance of federal aid for college education in explaining college premium.
In the first chapter, I document the life-cycle earnings profile for the 25-year- old college- and high school-educated white men in 1940, 1950, 1960 and 1970. I find that later cohorts have flatter average life-cycle earnings profile. Using a version of the Ben-Porath model, I propose an explanation based on the composition effect. In my model, all individuals have a high school diploma and are differentiated by their ability. They must decide whether to work or go to a four-year college. There is a threshold ability above which individuals choose to attend college and below which they work. All cohorts face the same ability distribution and an exogenous sequence of wage rate per unit of human capital that grows at a constant rate. A higher initial level of wage rate increases college attainment implying that the average ability is lower for both college- and high school-educated individuals. From the Ben- Porath model, lower ability individuals have less steep increment in their earnings. This implies that the average college (and high school) life-cycle earnings profile for the 1970 cohort will be flatter than that of the 1940 cohort. My model is able to quantitatively explain 67 and 35 percent of the flattening in the average life-cycle earnings profile for college and high school-educated individuals, respectively.
Since the late 1970s, there has been a strong increase in the college premium. While most papers focus on skill-biased technical change, the second chapter explores the role of federal aid as a possible source of inequality. I build a model where all individuals have a high-school diploma but are heterogeneous with respect to their innate abilities and initial human capital. They decide whether to attend college to accumulate more human capital before working, or to start working right away. The production function for human capital in college requires two inputs: human capital and goods. In this context, two mechanisms are key for the behavior of the college premium. First, federal aid makes it easier to afford the goods input in the human capital technology. This induces college students to accumulate more human capital and consequently, they have higher earnings. Second, as more individuals attend college due to rising income, the composition of college graduates changes: more low- ability individuals attend college, implying a decrease in average college earnings. A calibrated version of the model accounts fully for the rise in the college premium. Federal aid alone accounts for about 70 percent of the rise.
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Paris, Christian. "The role of CTCF in the life cycle of human papillomavirus." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6367.
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Papillomaviruses (PV) are epithelium specific DNA viruses that can cause health problems ranging from harmless warts to invasive cancer. Papillomavirus induced tumours most often arise in the cervix where human papillomavirus (HPV) infections were shown to cause 99.7 % of all malignancies. This study aims to map binding sites of the multifunctional host protein CCCTC binding factor (CTCF) to the papillomavirus genome, validate them and determine the function of CTCF in the papillomavirus life cycle. Computer predictions of CTCF binding sites in the sequence of 8 different PV revealed a CTCF binding pattern including a conserved high-affinity binding site around nucleotide 3000 in high risk HPV and around nucleotide 5400 in low risk HPV. This binding pattern was experimentally confirmed using electrophoretic mobility shift assays (EMSA). The binding site around nucleotide 3000 in HPV18 was mutated and human foreskin keratinocytes (HFK) were transfected with mutant and wild type HPV18 to analyse the effect of the mutation on viral gene expression and life cycle. Western blotting of methylcellulose differentiated HFK revealed earlier expression of E2 and decreased expression of E1^E4 in the mutant compared to the wild type. Immunostaining of organotypic raft cultures grown from the mutant maintaining cells showed a significant increase in proliferating cells compared to the HFK maintaining the wild type. This was accompanied by pseudo-differentiation of keratinocytes since the cells of the granular layer of the raft expressed the terminal differentiation marker loricrin but maintained the morphology of undifferentiated cells. Thus CTCF was shown to have a major impact on the HPV life cycle and it may play a role in HPV induced carcinogenesis. Furthermore a function of CTCF in long term maintenance of the viral episome was revealed as cells maintaining the CTCF mutant were shown to lose episomes more quickly compared to wild type maintaining cells.
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Harvey, Olivia School of Sociology & Anthropology UNSW. "(Re)producing the human : reflections on technology and nature." Awarded by:University of New South Wales. School of Sociology and Anthropology, 2005. http://handle.unsw.edu.au/1959.4/20580.
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Contemporary culture abounds with stories about how new technologies are radically altering human existence. In many respects it seems intuitively obvious that there is nothing new in this, and that new techniques for doing things change social relationships. Indeed, this has been a common refrain in the modern world. Yet there is something strange about the most recent variations of how the social impact of technological change is understood. In the early twenty-first century, new technologies are argued to have changed our daily lives so much so that what we take as the most fundamental features of human experience can no longer be assumed. Specifically, in its more contemporary articulation, the argument that new technologies have radical social consequences insists that the human subject is undergoing a fundamental transformation into something entirely different: the cyborg or posthuman. This thesis offers an exploration of some of the assumptions that underpin contemporary accounts of new technologies and their presumed impact on human experience. Using a textual analysis methodology, this thesis takes up discussions from various areas; feminist technology studies, technology studies, the history and politics of technology as well as continental philosophy to explore changing perceptions about 'technology' and 'the human'. In addition, this thesis examines some curious examples from this diverse field in order to highlight some of the inherent ambiguities and paradoxes that endure when technology is assumed to be a detachable supplement. Assisted reproductive technologies, animal tool-use, automata, stem-cell research and human cloning, all indicate that the criteria which typically define 'the human' or 'technology' are far more amorphous than is usually presumed. What comes out of these deliberations is an intriguing tension between how both technology and human subjectivity are understood which complicates our understanding of the difference between humans and machines, nature and culture, and agency and instrumentality. In turn, this raises certain questions about the experiential implications for contemporary subjectivity.
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Campbell, David Michael. "Empirical studies of earnings over the life cycle in Great Britain." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368071.
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James, Claire Deborah. "A study of PDZ protein expression during the human papillomavirus life cycle." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6127/.
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The E6 protein of oncogenic α-human papillomaviruses encodes a conserved C-terminal PDZ binding motif (PBM). Conservation of an overlapping kinase recognition site has shown that phosphorylation negatively regulates the E6:PDZ interaction. Many E6 PDZ targets are associated with signalling complexes that regulate cell proliferation and polarity. This study used primary keratinocyte-based models of HPV16 and 18 life cycles to investigate the expression of PDZ targets and the functional role of PBM phosphorylation. The data indicate that changes in total levels of major E6 PDZ targets are not associated with E6-PBM activity. Interestingly, transcription profiles of E6-PBM targets DLG1, PATJ and PTPN13 are dramatically changed in the presence of HPV16 and 18, whilst others remain unaffected. Further analysis of transcriptional changes of DLG1 revealed upregulation of specific alternatively spliced isoforms, including a novel isoform containing an exon previously thought to be intronic. This investigation revealed that phosphorylation of the PBM is linked to oncoprotein stability, presenting a potential regulatory mechanism of E6 PDZ interactions during the virus life cycle. Together, these data offer interesting new perspectives on interactions between oncogenic HPV types and PDZ domain-containing targets and indicate that deregulation of their function by the virus may occur through multiple mechanisms.
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Gabor, Juliana. "Role and regulation of tRNALys3 in the life cycle of human immunodeficency virus type 1." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19462.
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tRNALys3 is selectively packaged into HIV-1 during viral assembly, and is placed upon the primer binding site (PBS) of the viral genome where it acts as the primer for reverse transcriptase. This Ph.D. project involved studying the factors involved in the regulation of tRNALys packaging, as well as the effect of overexpression of tRNALys3 in the virion.
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Mole, Sarah. "Regulation of splicing related SR proteins during the life cycle of human papillomavirus type 16." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438066.
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KAUSHAL, HIMANSHU. "HOW DOES ISO 14001:2015 STANDARD IMPACT OF LIFE CYCLE PERSPECTIVE TOWARD ORGANIZATION." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-42191.
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Holland, Caroline Anne. "Housing histories : older women's experience of home across the life course." Thesis, n.p, 2001. http://ethos.bl.uk/.
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Yasin, Cepnioglu. "An Assessment of the Commercial Accommodation Facilities in Umeå : Tourism Area Life-Cycle Perspective." Thesis, Umeå universitet, Institutionen för geografi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-171325.
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Tourist destinations have been under a significantly growing interest of academia from the second half of the 20th century. The underlying patterns that are shared by destinations’ past, and shapes their future constitute a good share for the context of this interest. This study applies Butler’s Tourist Area Life-Cycle model to an urban tourism destination, Umeå. The model puts the life of a tourism area (destination) on an s-curve and defines several stages on the curve with designated features. Application of the model to the case of Umeå is limited to accommodation branch of the hospitality industry to apply a comprehensive approach and it shows that the city is in the development stage for in this particular branch. However, there are some divergences in the case compared to the model. The capacity edge that causes pressure to the tourist destinations growth does not appear where the model expects, and some stage features appear to take place in a different sequence than the original model. Consequently, the study connects these divergences to the fact that Umeå is an urban destination and also offers a modified version of the model that might be a good alternative for applications on other urban tourist destinations.
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Shariat, Zadeh Navid. "Standardized architectures for information integration and life cycle management in the domain of production engineering." Doctoral thesis, KTH, Industriell produktion, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-206381.
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While design and management of production systems based on digital models brings benefits, the communication of models comes with challenges since models typically reside in a distributed heterogeneous IT environment using different syntax and semantics. Coping with heterogeneity requires an appropriate integration strategy and methodology. One main paradigm to integrate information and consequently IT-systems is to deploy standardized information models. In particular, ISO 10303 STEP has been endorsed as a suitable standard to exchange a wide variety of product manufacturing data. The representation and integration of product, process and production resources information using different STEP application protocols are well covered and extensively investigated by many researchers. However, the information representation and integration of logical relations of material flow such as product routing, and its integration with factory layout information has been less subject of research focuses. Hence, this thesis first contributes to identifying, describing and clarifying information requirements for an integrated representation of material flow logic and plant layout using the STEP standard. One the other hand, service-oriented IT-tool integration solutions are increasingly deployed for the data and tool interoperability, especially with the evolution of Open Services for Lifecycle Collaboration (OSLC) whose focus is on the linking of data from heterogeneous software tools. OSLC focuses on the integration of the most common concepts across domains. Assuming a loosely coupled distributed architecture of IT-tools and services, OSLC adopts the Linked Data (LD) approach to ensure data consistency across the data sources. Thus the thesis studies the use of OSLC for tool integration and has found that it cannot be practiced independently for all types of integration in the production engineering domain. Therefore, in practice, there should be a combination of the standardized information and linked data approaches to facilitate the integration process. Thus, this thesis investigates the integration applicability of linked data and OSLC, the principles behind them, and criteria to identify where to use which approach. In addition, the thesis explores the synergy between the standardized information and linked data approaches and consequently suggests an approach based on a combination of these. Further, different computer applications in industrial cases were implemented to verify the suggested approaches. Finally the thesis is concluded with a discussion and suggestions for future work.<br><p>QC 20170503</p>
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Gerdne, Therese. "The Importance of Human Capital in Export Performance." Thesis, Jönköping University, JIBS, Economics, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-269.
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<p>The purpose of this thesis is to analyze the effect of human capital in Swedish export. Human capital is here expressed as the number of employees in the private sector per municipality with university education of at least three years. Two regression models were tested with aggregated export value/municipality and export value per kilo/municipality as dependent variables. Human capital as well as the total accessibility to R&D was assumed to have a positive impact on the Swedish export performance.</p><p>During the last decades many economists have attached great importance to education, knowledge and investments in R&D. Sweden is in general abundant in human capital and have also several world leading companies characterized by knowledge intensive production and export. According to the Product Life Cycle Theory, Sweden should focus on the first phase that requires high input of human capital and product competition to maintain the competitiveness in the international market.</p><p>The results indicate as expected that the access to human capital as well as accessibility to R&D have a positive impact on the Swedish aggregated export value and export value per kilo. The assumption about human capital being even more important in high value export could not be confirmed by the results. Innovation promoting investments together with continuous efforts to improve innovation nets and interaction possibilities are presumed to be important factors for Swedish competitiveness also in the future.</p>
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Morgan, Ethan Luc. "The role of STAT3 during the human papillomavirus (HPV) life cycle and in HPV-associated cervical cancer." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22723/.
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Human papillomaviruses (HPV) activate a number of host factors to control their differentiation-dependent life cycles. The manipulation of these host cell signalling pathways can result in the developement of cancer and HPV is responsible for around 5% of all cancers worldwide. Gaining a better understanding of these virus: host interactions is critical for the development of treatments for HPV infection and associated cancers. The transcription factor signal transducer and activator of transcription (STAT)-3 is important for cell cycle progression and cell survival in response to cytokines and growth factors. STAT3 requires phosphorylation on Ser727, in addition to phosphorylation on Tyr705 to be transcriptionally active. Although STAT3 has been shown to be hyperactive in many cancers, including cervical cancer, there is a paucity of information on the role of STAT3 during the productive HPV life cycle and HPV-associated cancers. Utilising a primary keratinocyte system to study the full HPV life cycle, this study demonstrates that STAT3 is essential for the HPV18 life cycle in both undifferentiated and differentiated keratinocytes. Furthermore, the HPV E6 oncoprotein is identified to be sufficient to induce the dual phosphorylation of STAT3 at Ser727 and Tyr705 by a mechanism requiring Janus kinases and members of the MAPK family. Importantly, silencing of STAT3 protein expression by siRNA or inhibition of STAT3 activation by small molecule inhibitors, or by expression of dominant negative STAT3 phosphorylation site mutants, results in blockade of cell cycle progression. Organotypic raft cultures of HPV18 containing keratinocytes expressing a phosphorylation site STAT3 mutant display a profound reduction in suprabasal hyperplasia, which correlates with a loss of cyclin B1 expression and increased differentiation. Finally, increased STAT3 expression and phosphorylation is observed in HPV positive cervical disease biopsies compared to normal cervical tissue, highlighting a role for STAT3 activation in cervical carcinogenesis. In confirmation of this, STAT3 phosphorylation was demonstrated to be in increased in HPV+ cervical cancer cells when compared to HPV- cervical cancer cells. Detailed mechanistic study identified that this was due to an increase in IL-6 auto/paracrine signalling induce by HPV E6 in an NFkB-dependent manner. Finally, STAT3 was demonstrated to essential for the proliferation, migration and invasion of HPV+ cervical cancer cells. Utilisation of a clinically available inhibitor of JAK2, an upstream kinase for STAT3, also resulted in a similar impairment of proliferation, migration and invasion. In summary, our data provides evidence of a critical role for STAT3 in the HPV18 life cycle and in HPV+ cervical cancer cells. This suggests a possible therapeutic target for both HPV infection and in the treatment HPV+ cervical cancer.
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Foltz, Douglas Jay. "Holistic development." Online full text .pdf document, available to Fuller patrons only, 2003. http://www.tren.com.
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Kleinhen, Rachel M. "From cohabitation to marriage: couples' perceptions of the transition stage II of the family life cycle." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/39718.
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Cohabitation, as a relationship form, is becoming much more common in the United States. Approximately half of the persons currently in their 30s cohabit prior to marriage and more than half of all recent marriages were preceded by cohabitation between those marrying. Through the use of in-depth interviews I studied the transition between this new form of "dating" and the traditional course of marriage. Couples who cohabited with each other prior to their marriage were interviewed about how they made the transition to marriage. Couples' perceptions are what changed in the transition from cohabitation to marriage. The transition comes about through the passage of time, through external events which make an impact on the couple's relationship, and through beliefs about what certain events and behaviors mean.<br>Ph. D.
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McLaughlin, Pamela F. "Analysis of the integrated defense acquisition, technology, and logistics life cycle management framework for human systems integration documentation." Thesis, Monterey, California. Naval Postgraduate School, 2009. http://hdl.handle.net/10945/4410.
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Approved for public release, distribution unlimited<br>L framework can potentially aid in redefining how the Navy should address HSI, by identifying areas where HSI policies and guidelines should exist, but currently do not (i.e., gaps), and then proposing ways to close those gaps and streamline the HSI process as a whole throughout the Navy. This thesis suggests a potential, strengthened framework for HSI in the Navy, based on the information and findings gathered from not only the current framework, but also current Navy policies. The outcome of this thesis is to improve the entire HSI process throughout the Navy and help ensure that HSI is used effectively throughout the acquisition process.
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Harris, Leanne. "Association of human papillomavirus type 16 E2 with ChlR1 : implications for E2 function and the HPV life cycle." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6058/.
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Human papillomavirus (HPV) E2 is essential for transcriptional regulation of viral oncoprotein expression and the replication and persistence of episomal HPV genomes. Episomal persistence is mediated by tethering of viral genomes to host cell chromosomes during mitosis. Previous work demonstrated that interaction of E2 with the cellular DNA helicase ChlR1 is necessary for viral genome tethering. Therefore, disruption of this interaction is a potential therapeutic target for persistent HPV infections. To investigate the use of fragment-based drug discovery in the development of novel inhibitors of the E2-ChlR1 interaction, a fragment library was screened to identify those that bind E2 and several hits were identified. Concurrently, the interaction between HPV16 E2 and ChlR1 was characterised and shown to be a direct protein-protein interaction. The binding sites within E2 and ChlR1 were mapped and this information was used to identify a mutant E2 protein unable to bind ChlR1 (E2-Y131A). E2-Y131A was functionally characterised. HPV16 genomes encoding E2 wild type and Y131A were transfected into primary human keratinocytes to study the differentiation-dependent virus life cycle. Mutant genomes failed to establish genome maintenance, providing strong evidence that the interaction between HPV16 E2 and ChlR1 is necessary for the persistence of HPV infection.
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Dupont, Stefan A. "The Functional Roles of the Human Immunodeficiency Virus Type-1 Matrix Protein during Viral Life Cycle: A Dissertation." eScholarship@UMMS, 2000. http://escholarship.umassmed.edu/gsbs_diss/191.
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The human immunodeficiency virus type-1 matrix (HIV-1 MA) is best described as a multi-functional, structural protein. However, the multitude of functional activities ascribed to this viral component is not nearly as interesting as are its seemingly paradoxical and opposing roles during the viral life cycle.
At the time of virus infection, HIV-1 MA remains associated with the reverse transcription complex, in which viral nucleic acids are synthesized, and facilitates its translocation to the host cell nucleus (Bukrinsky, Sharova et al. 1992; Bukrinsky, Sharova et al. 1993). This activity of MA has been proposed to form the basis for the infection of non-dividing cells (Bukrinsky, Haggerty et al. 1993). An interaction between the C-terminally phosphorylated form of MA and HIV-1 integrase, an integral component of the complex, was initially proposed to mediate this association (Gallay, Swingler et al. 1995; Gallay, Swingler et al. 1995). However, conditions which promote dissociation of integrase from the reverse transcription complex do not reduce MA association (Miller, Farnet et al. 1997). The possibility of a direct interaction between MA and the viral genome is discussed in Chapter III.
The nucleophilic nature of HIV-1 MA is paradoxical with its reported activity in targeting the viral precursor proteins to the cytoplasmic membrane (Krausslich and Welker 1996), during the particle production phase of the viral life cycle. Furthermore, MA when expressed in the absence of other viral proteins exhibits a cytoplasmic localization (Fouchier, Meyer et al. 1997); a result which does not support a nuclear translocation role for this protein. The work presented here resolves this seemingly controversial issue.
We demonstrate that MA exhibits a strong nuclear export activity. This newly discovered activity is designed to effectively counteract the protein's innate nucleophilic nature, thus maintaining a cytoplasmic localization. The nuclear export function of MA is sensitive to changes within the conformation of the protein as C- and N-terminal deletions, as well as point mutations in the protein, abolish the activity. Furthermore, the export activity is mediated by the Crm1 NES receptor (Fornerod, Ohno et al. 1997; Fukuda, Asano et al. 1997; Ossareh-Nazari, Bachelerie et al. 1997) despite the lack of a leucine-rich export signal within the matrix coding region. Therefore, the interaction between matrix protein and Crm1 is most likely to be mediated by another, perhaps cellular, protein. Any changes in matrix structure may lead to the disruption of this protein-protein interaction. We discuss a model implicating a phosphorylation event in the inactivation of this nuclear export signal.
An even more fascinating issue regards the role of this nuclear export activity, during the viral life cycle, and is detailed in Chapter II. In short, mutations in MA which impair its nuclear export activity result in nuclear accumulation of the precursor Gag polyprotein (Pr55) and the nucleocapsid-associated viral genomic RNA. As a result, non-infectious virions deficient in genomic viral RNA are produced. Therefore, drugs designed to block this export activity can undermine the carefully orchestrated course of events during HIV replication and can shut down the growth of the virus.
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Lang, Jeanine A. McLaughlin Pamela F. "Analysis of the integrated defense acquisition, technology, and logistics life cycle management framework for human systems integration documentation." Monterey, California : Naval Postgraduate School, 2009. http://edocs.nps.edu/npspubs/scholarly/theses/2009/Dec/09Dec%5FLang.pdf.
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Thesis (M.S. in Operations Research)--Naval Postgraduate School, December 2009.<br>Thesis Advisor(s): Shattuck, Lawrence G. Second Reader: Miller, Nita Lewis. "December 2009." Description based on title screen as viewed on January 27, 2010. Author(s) subject terms: Human Systems Integration, Acquisition, Manpower, Training, Personnel, Human Factors Engineering, Safety Health Hazards, Human Survivability, Policy. Includes bibliographical references (p. 93-94). Also available in print.
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Salmani, Mona. "Cost Modelling of Resources in the Personnel Life Cycle : A case study of the Swedish Air Force." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Informatik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-18671.
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Over the past few years, the Swedish Armed Forces (SAF) in similarity with forces inmany other countries has been undergoing a major process of change. One of the majorreforms is the government‘s decision to replace the compulsory military service with aprofessional army. In order to manage this, SAF requires tools to evaluate the long-termconsequences of different decisions regarding its manpower, such as different recruitment,training and educations policies, mission rehearsal, mission planning, and etc.These tools should, for instance, include information about different type of resourcessuch as weapon systems and materials required for conducting training and missions, asthey directly affect planning of courses, training sessions, etc. These resources have a totallife cycle cost that besides the acquisition cost includes maintenance costs, cost forspare parts and cost of human resources which are required for training and deploymentof the resource.This thesis has been performed in collaboration with FOI (Swedish Defence ResearchAgency) in order to support development of a decision support simulation tool for assistingin the personnel planning process of the SAF. The main objective is to determinethe connection between LCC (Life cycle cost) of personnel and LCC of system Hence,the study facilitates flow of information between the Human Resource Department atSAF and the Defence Material Administration (FMV) in order to base their decisionmaking process on more accurate and complete information about resource costs relatedto different activities that are important to both organizations.In this paper, the inductive approach is the chosen approach as appropriate theories arestudied and used for making hypothesis in order to create a new model. Consequentlythe interpretive approach is deployed as it is associated with this reasoning style. Furthermore,the research purpose is exploratory as it is essential to identify the resourcescost factors and the relations between them.The research strategy is case study and the utilized technique for collecting primary datais interview. The secondary data is gathered by studying hard or digital copy of books,articles, journals, handbooks and dictionaries.Hence, through a set of interviews, information about different activities regarding theeducation and operation phases of the fighter pilots at the Swedish Air Force has beencollected. As a result a corresponding model consisting of resources employed in thoseiiactivities and their relation has been developed. The model is based on the Unified EnterpriseCompetence Modelling Language (UECML).The contributions of this thesis are (1) Identification of the cost factors of personnelrelatedactivities including courses, training sessions and missions, 2) Classification ofcost factor elements in a number of classes, and 3) Illustrating the connections betweenthe classes using UECML.
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Bourgeois, Chantal G. "The impact of AIDS on the life cycle of young gay men." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0022/MQ50697.pdf.
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Lemieux, William J. "Urban housing tenure choice from an economic and demographic perspective." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24400.
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This thesis evaluates the influence of family life cycle stages as a factor of residential tenure choice. The importance of tenure choice is being more widely recognized through the greater use of housing market and demand models. The purpose of this thesis is to contribute to the knowledge of the tenure decision process so that planners, policy makers, and other market participants are more effective in achieving their goals.
In this study an empirical analysis is performed using urban Canadian data for households with head's between the age of 25 and 44. Eight family life cycle stages are used to classify households. A joint tenure choice and mobility model is used to test for ownership probability differences among the life cycle stages. Within the study framework allowances are made for recent and non-recent movers.
The results indicate that family life cycle stages impact on tenure choice, and that this occurs outside of their impact on expected mobility (or holding period). The life cycle stage impact is strong through the effect of household reactions to income and wealth, and weak through just group membership. This suggests that utility preferences for ownership tend to shift as households progress through various life cycle stages. When elasticities are estimated they are found to reflect the different housing consumption and mobility decisions of households at different family life cycle stages. This also
supports the concept of a changing utility preference function.
In general this study finds that tenure choice is affected by consumption and mobility influences that result from different family life cycle stage demands. Further research studies, government and business policies, dealing with residential tenure choice are encouraged to recognize family life cycle stages and the impact of household expected mobility.<br>Business, Sauder School of<br>Real Estate Division<br>Graduate
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Bardo, Anthony Richard. "The Comparability of Happiness and Life Satisfaction: A Life Course Approach." Oxford, Ohio : Miami University, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1272746230.
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Petersen, Hans-Georg. "Poverty, human capital, life-cycle and the tax and transfer bases : the role of education for development and international competition." Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2011/5396/.
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The paper is based on an individual life-cycle model, which describes the purely economic components of human capital. The present value of human capital is determined by all future income flows, which at the same time constitute the individual as well as the total tax base of a nation. Therefore, the income of the productive population determines the total tax revenue, which is spent for public goods (including education) and transfers (for poverty reduction). The efficient design of the education system (by private and public education investments) determines the quality of the human capital stock as well as the future gross income flows. The costs of public goods and the transfer expenditures have to be financed from the total tax revenue, which also affects the individual tax burden via the specific tax bases and tax rates. Especially the redistribution of income is connected with serious disincentives, influencing the preferences for work and leisure as well as for consumption and saving.
An efficient tax and transfer system being accompanied by an education system financed in public private partnership, which treats equally labor and capital income, sets positive incentives for the formation of human, financial, and real capital. An important prerequisite for a sustainable growth process is the efficient design of the social security system, being based on the family as well as a collective risk equalization scheme. If that system is diminishing absolute poverty in an appropriate time period by transfers and vocational education measures for the grown-up as well as high quality primary, secondary and tertiary education programs for the children, the transfer expenditure would decrease and the tax bases (income and consumption) increase, lowering the burden on the productive population. For the first time, this micro model presented in this paper pools all the relevant variables for development within a simple life-cycle model, which can also be used for a powerful analysis of the current failures in existing tax and transfer schemes and fruitful empirical investigations. Hence, an efficient tax and transfer scheme strongly contributes to an improved national position in the global competition.
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Pawa, Nishant. "Probing the viral determinants of cellular fusion and the early post-entry events of the human immunodeficiency virus life cycle." Thesis, Queen Mary, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545977.
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Ryckman, Kirssa Cline. "Repression and the Civil-War Life-Cycle: Explaining the Use and Effect of Repression Before, During, and After Civil War." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/238651.
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The central goal of this project is to better understand the relationship between civil war and repression at each phase of the "civil-war life-cycle," which is composed of the escalation and onset of civil war, the war itself, and the post-war period. The project then seeks to understand the role of repression in civil war onset, where repression is argued to be either a permissive condition or a direct cause of civil war, where the role of repression is tied to what type of civil war occurs. As a permissive condition, repression essentially provides the opportunity for a group to carry out an attack, invasion, mutiny, and the like. During other conflicts, repression may be a direct cause of the war. The repression of protest movements may lead those groups to view "normal," non-violent political channels as closed, while also increasing grievances and therefore their willingness to fight. This direct mechanism along with the escalation process that leads to civil war is explored in depth, using data from the 2011 Arab Spring. This project also seeks to explain when conflicts are likely to be accompanied by harsh repression and the targeting of civilians, and to address whether that strategy is effective. It is argued that insurgencies rely on civilian populations for material and non-material support; if the government targets this resource pool then it may be able to undercut that lifeline and thus the military effectiveness of the group. Yet, as repression is costly this is only a strategy likely to be employed when the rebels are gaining ground, when they are relatively strong and militarily effective. As such, governments that employ repression as a war-time strategy are likely beginning from a point of weakness or disadvantage. It is thus further argued that the "gamble" of repression is not likely to reverse the government's fortunes; rather, wars marked by high levels of repression are most likely to end in stalemate. Finally, the use of, or the restraint from using, repression in post-war periods is also explored. Little attention has thus far been paid to the use of repression in post-conflict states, despite the growing literature on the consequences of conflict and the importance of this time for rebuilding and establishing peace. Here, the transformation of the war-time threat, together with various constraints against using repression in the post-war period, are considered.
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Müller, Toni. "A psychobiography of Paul Jackson Pollock." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1554.
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While the value of psychobiographical research continues to be debated, interest in this area is growing on an international basis. From the ever increasing number of studies being conducted in connection with academic institutions in South Africa, the vitality and worthiness of studying lives lived in conjunction with the applicability of psychological theories is showing itself to be an exciting world in which to participate. This particular research study aimed to explore and describe the developmental life stages of Paul Jackson Pollock. Pollock was, and continues to be, a controversial figure in the art world as there is much debate over the artistic merit of his paintings. Unconventional in all that he did, Pollock challenged the art world by moving beyond paintbrush and easel to throwing paint across canvasses laid out on the floor. Around these emerging artworks he would move in a staccato dance, mesmerising those present by the way he made art immediate using his entire body to create the abstract image. Pollock is credited with being the pioneer of abstract expressionism in the United States, and to date his paintings are credited as being among the most expensive ever sold. He struggled with alcoholism and emotional instability throughout his teens and adult life. His alcoholism eventually caused his death at the age of 44 when, while heavily intoxicated, he drove his car into a tree a few metres from his home. No known literature has adopted an exclusively psychological stance when studying the life of this individual. The progression of Pollock’s lifespan development was filtered through Erikson’s (1950) theory of psychosocial stages. Erikson’s (1950) theory takes a holistic, biopsychosocial approach to human development, with an emphasis on ego development. Data was collected from both primary and secondary sources to enhance internal validity, and the data was then analysed according to Miles and Huberman’s 1994 general approach, taking Alexander’s (1990) nine identifiers of salience into necessary consideration. Using this framework, it was found that Jackson Pollock’s development coincides with Erikson’s theoretical psychosocial stage constructs, lending weight to Erikson’s theory. While Pollock’s life paralleled Erikson’s (1950) theory in many ways, the theory failed to provide enough definition with regards to constructs and intrapsychic processes. However, this study has also shown that there is great value and relevance to be found in Erikson’s (1950) theory, even though it was developed over fifty years ago.
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Goode, Christine Marie. "Fast forward the dehumanizing emphasis on linear time in the North American television system /." Theological Research Exchange Network (TREN) Access this title online, 2005. http://www.tren.com.
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Bennett, Donald G. "Seasons of adulthood an integrated identity /." Theological Research Exchange Network (TREN), 1990. http://www.tren.com.
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Pipparelli, Aurélien. "Contribution à l'étude du cycle de la cellule endothéliale cornéenne humaine." Phd thesis, Université Jean Monnet - Saint-Etienne, 2010. http://tel.archives-ouvertes.fr/tel-00677341.
Full textAbstract:
Les cellules endothéliales (CE), monocouche de cellules hexagonales jointives situées à la face interne de la cornée, assurent la transparence de ce tissu essentiel à la vision. Peu avant la naissance, ces CE perdent leur capacité proliférative en restant bloquées en phase G1du cycle cellulaire. Le non remplacement des cellules mortes est responsable de certaines pathologies cécitantes dont la cornea gutatta et les dystrophies bulleuses du pseudophaque sont les prototypes et comptent parmi les premières indications de greffe de cornée. Les mécanismes moléculaires impliqués dans l'arrêt de la prolifération de ces CE restent très partiellement expliqués. La première partie de cette thèse a pour objectif d'identifier si des changements d'expression transcriptionnelle des gènes régulateurs du cycle cellulaire interviennent au cours de l'organoculture (OC) et de la culture in vitro, afin de définir au mieux les cibles potentielles à inhiber ou celles à surexprimer pour re-déclencher une prolifération cellulaire contrôlée. Pour la première fois, nous avons mis en évidence des profils transcriptionnels variables en fonction de l'environnement des CE, avec une activation globale de l'expression des gènes en OC de routine et en culture primaire et l'expression accrue de gènes impliqués dans l'arrêt du cycle cellulaire en différents points comme DIRAS3, GADD45A, p15 p16, p18 et p19 ou impliqués dans la régulation du cycle des CE comme le complexe ubiquitine/protéasome (culines, APC...), laissant supposer que les freins antiprolifératifs sont encore plus complexes. Dans la seconde partie, nous avons développé une méthode d'analyse de la viabilité de l'endothélium pan-cornéenne afin d'évaluer au mieux la viabilité des cellules endothéliales sur les greffons. Nous avons développé un outil innovant de mesure combinant un triple marquage Hoechst/Ethidium/Calcéine AM à l'analyse pan-endothéliale permettant d'évaluer de définir la notion originale de densité en cellules viables d'une cornée. Cette technique peut être appliquée à l'analyse de n'importe quel procédé chirurgical ou non, susceptible d'altérer directement ou indirectement l'endothélium cornéen
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Romeiras, de Lemos M. "Sustainable competitive advantage in PFI : a systematic and holistic approach to identify the CSFs in risk management in PFI, taking into account the whole life cycle." Thesis, University of Salford, 2002. http://usir.salford.ac.uk/14839/.
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I wish to express my gratitude to Professor Martin Betts and Professor Luis Tadeu de Almeida, my joint supervisors, for their support and encouragement throughout the entire period of my research. My special thanks to Dr. David Eaton for his invaluable assistance, continued support, encouragement and patience. I would like to thank all staff from the School of Construction and Property Management of Salford University and from the Departamento de Engenharia e Gestão do Instituto Superior Técnico for their help during this period. My thanks to my colleagues in my Department in Lisbon and to my research colleagues in Salford. Their insights, opinions and support were of great value to my research and for myself. I would like also to express my gratitude to all that contributed to my research, making themselves available for interviewing and also providing material for my research. Thanks to my parents, all my family and friends for their support. Finally, a very special kiss to my sons and daughter: Luis Miguel, Maria Joana and Filipe Manuel for their love, encouragement and patience during this period as my time was short for them.
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Medis, Michael D. "Erik Erikson's eight ages of man in context of the Orthodox Christian tradition." Online full text .pdf document, available to Fuller patrons only, 2000. http://www.tren.com.
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McKechnie, Allan. "The use of developmental stages as a model for addressing and assessing spiritual formation and maturity." Theological Research Exchange Network (TREN), 2008. http://www.tren.com/search.cfm?p046-0069.
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McKechnie, Allan D. "The use of developmental stages as a model for addressing and assessing spiritual formation and maturity." St. Paul, MN : Bethel Seminary, 2008. http://dx.doi.org/10.2986/tren.046-0069.
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Pugh, Alice Georgia. "An investigation of post-translational modification of human papillomavirus E4 and the role of modified E4 proteins during the virus life cycle." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/823/.
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Infection with human papillomaviruses (HPV) is the etiological basis for cervical cancer. The HPV E1^E4 protein is proposed to be a major regulator of the HPV life cycle and the multiple and diverse activities associated with E1^E4 suggest that it is a multi-functional protein. This thesis has sought to address the hypothesis that phosphorylation and proteolysis contribute towards the pleiotrophic functions of the E1^E4 protein, and has investigated the functional significance of these E1^E4 post-translational modifications during the HPV life cycle. This study has uncovered the novel finding that the E1^E4 protein of HPV type 18 (HPV18) exists as a phospho-protein within cells and is a substrate for multiple cellular kinases in vitro. The phospho-acceptor residue for cyclin-dependent kinases (CDK) 1 and 2 has been identified as threonine 23, whilst serine 58 is phosphorylated by protein kinase A (PKA). Furthermore, a cyclin binding motif (\(^{43}\)RRL\(^{45}\)) within the HPV18 E1^E4 protein is required for association with active CDK complexes and this association may influence CDK activity since the activity of CDK2-cyclin A was shown to be reduced in the presence of HPV18 E1^E4. This thesis has revealed that HPV18 E1^E4 is a target for N-terminal proteolysis, and this post-translational modification occurs during the HPV18 replication cycle. Key elements necessary for proteolysis have been mapped to a conserved leucine-rich sequence (LLXLL) present at the N-terminus of the HPV18 E1^E4 protein. Since E1^E4 expression is required for HPV18 genome amplification, N-terminally truncated E4 species may contribute towards its role in the replication cycle. To examine this hypothesis, mutations that attenuate E1^E4 proteolysis were introduced into HPV18 genomes and transfected into human foreskin keratinocytes (HFK). Mutation of the leucine-rich motif prevented efficient proteolysis of the E1^E4 protein during the HPV life cycle and resulted in reduced viral genome amplification within differentiating HFKs suggesting that efficient E1^E4 proteolysis may be required for this E4 function.
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Willis, Lynn Sherri. "A psychobiographical study of Robert Nesta “Bob” Marley." Thesis, Nelson Mandela University, 2017. http://hdl.handle.net/10948/13480.
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Psychobiography is a qualitative research design used to explore and understand the life story of an individual through the lens of psychological theory. The application of theory is typically done to finished lives of well-known or enigmatic people, and covers the person’s entire lifespan. The aim of the study was to explore and describe the personality development of the Rastafarian reggae musician Bob Marley.To meet this aim the study created a comprehensive picture of Marley’s life within the particular social, economic and historical context in which he lived. Marley’s work was considered influential both during and after his life. His music is listened to by diverse groups of people, and is known internationally. Marley’s personality was explored by applying Eric Berne’s theory of Transactional Analysis (TA) to his life story. Data was collected and analyzed using a strategy consisting of three steps, namely, data reduction, data display, and conclusion drawing and verification. Results of the study indicated that TA is a suitable theory for creating insight into the life of this historical figure, and has led to an increased understanding of the application of this psychological theory. Lastly, the study has contributed towards increasing the number of psychobiographical studies conducted in the South African context.
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Källviks, Mikaela, Marcus Nilsson, and Marcus Karlsson. "A Motivational Journey : A study about the entrepreneur and the changes in motivation from start-up to present." Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Företagsekonomi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-26762.
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The purpose of this thesis is to identify what motivational changes occur while a lifestyle entrepreneur moves through three different organizational stages. The focus will however be on stage one and three. The problem of an under-researched field is addressed and how the motivation of specific lifestyle entrepreneurs, in these cases hairdressing salon owners, has changed. This thesis has been conducted with an interpretivistic viewpoint, an inductive approach and with a qualitative research method. The authors have selected to analyze the data through pattern matching and dividing the interviewees into two different case studies, one for each of the two chosen organizational stages in focus. In conclusion the authors found that intrinsic and extrinsic motivations have had different effects within all stages in the organizational life cycle. The authors have discovered that during stage one the intrinsic motivations play a large role. During stage one where the organization is small and young the lifestyle entrepreneurs are motivated by factors such as independence and self-efficacy. Stage two is a more extrinsic dominated phase with the factors integrated regulations and identified regulation as motivators. The third stage is a return to the intrinsic motivations with factors such as locus of control and egoistic passion. This is further explained within the chapter with help of the analysis and empirical findings. A figure has been presented to show the different phases and their motivational change.
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Huckins, Rachel. "Origination /." Online version of thesis, 2008. http://hdl.handle.net/1850/8831.
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Klotz, Jared Lee. "Foraging for Demand: Applying Optimal Foraging Theory to Decisions in a Simulated Business Context." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/theses/1053.
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Charnov's (1976) marginal value theorem has had success in predicting that animals will optimize net rate of gain when foraging in a patchy environment. The present study attempts to apply the marginal value theorem (MVT) to human behavior in a business setting in 3 Experiments. Businesses also attempt to optimize net rate of gain when choosing to discontinue one product in lieu of another using a product life cycle (PLC). Experiments 1 & 2 attempted to assess human behavior in a business context by varying time necessary to retool and monetary cost of retooling respectively. Experiment 3 attempted to add ecological validity by introducing variability to the PLC. The results of Experiments 1, 2, & 3 indicate that the MVT does not accurately predict human behavior in a business context, though methodological issues may have affected these results. Future research must be conducted in this area.
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Delury, Craig Phillip. "The role of the PSD95/Dlg/ZO-1 (PDZ) binding motif of human papillomavirus type 18 E6 oncoprotein in the virus life cycle." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3345/.
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A PSD95/Dlg/ZO-1(PDZ)-binding motif (PBM) in the E6 protein of high-risk, cancer-causing human papillomaviruses (HPV) targets a subset of cellular PDZ domain-containing proteins involved in diverse regulatory processes including cell polarity and proliferation, for proteasome-mediated degradation. Interaction with this select group of PDZ domain-containing proteins is negatively regulated by cAMP-dependent protein kinase (PKA) mediated phosphorylation of the E6 PBM. This thesis has sought to address the hypothesis that the PBM of E6 plays an important role within the HPV life cycle. This study has shown that deletion of the E6 PBM from HPV18 genomes affects the morphology and growth of viral episome-containing human keratinocytes and furthermore links E6 PBM function to viral episome replication (maintenance replication and differentiation-dependent amplification). Loss of negative regulation of the E6 PBM by mutation of the PKA recognition motif was associated with increased cell growth and indeed the growth of wildtype HPV18 genome-containing cells responded to changes in PKA signalling. Constitutive E6 PBM function was also associated with invasion of cells suggesting that malignant progression of HPV-infected cells may be linked to changes in PKA signalling. Modulation of the E6 PBM function in the viral genome-containing cells was associated with a change in protein levels of the PDZ domain-containing protein discs large (hDlg) and changes in the non receptor protein phosphastase PTPN13 specific species.
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Fowlin, Julaine M. "A Case Study on How Workers in a Fast-paced Environment Go Through the Knowledge Life Cycle When Dealing with Critical Incidents." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/73299.
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21st century work environments are becoming more dynamic; they are fast-paced and require critical incidents to be dealt with in a shorter time frame. At the same time, in order for organizations to survive knowledge management (KM) systems need to be in place that allow organizations to learn from these incidents and use the knowledge gained to solve new problems.
The knowledge life cycle consists of three phases: create, preserve, and disseminate. The knowledge life cycle also involves the transformation of knowledge from tacit to explicit, which is important to shift knowledge from the individual level to the organizational level; this represents a very important objective of KM.
KM is not a domain on its own but intersects with other areas such as organizational learning, performance support, and communities of practice. Learning and performance support are among the concerns of practitioners in the sister fields of instructional design and technology (IDT) and human performance technology (HPT). Yet still, there are not many studies that examine KM through the lens of these professions. There is a need for knowledge to be accessible and for structures to be put in place to facilitate the knowledge life cycle.
The purpose of this study was to explore how workers in a fast-paced environment go through the knowledge life cycle when dealing with critical incidents, and the factors that acted as driving and restraining forces. A single instrumental case study research design was used to study employees of a walk-in computer software help desk. The HPT model along with principles and procedures of critical incident technique were used to create a framework for data collection, which included interviews, a focus group session, and examination of extant data.
Findings revealed that workers went through the knowledge life cycle by making internal and external connections and both organizational and individual factors impacted the flow of knowledge. A disconnection between available tools and work processes posed the greatest barrier to going through all the knowledge life cycle process.<br>Ph. D.
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Van, Genechten Désirée Martina. "A psychobiographical study of Helen Keller." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1101.
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This psychobiographical study of Helen Keller’s life is exploratory-descriptive in nature. The subject was chosen through purposive sampling. The choice was based on the researcher’s personal interest and the remarkable impact this profoundly handicapped woman had within her society. Helen Keller also meets the psychobiographical requirements. These include that she is historically well known, inspirational, and her life has been completed. The study uses a qualitative, single case, interpretive research design. The design is employed to study Helen Keller’s entire life span within a formal psychological theory. The theory used in this study is Daniel Levinson’s (1996) Life Structure theory of adult development. Data for this study were collected from a variety of primary and secondary sources which provided alternative perspectives on her life. In addition, the data have been corroborated by historical texts, and newspaper and journal articles. Levinson’s (1996) theory divides the lifespan into four developmental eras, each with its own biopsychosocial character. Each era in turn is divided into shorter periods of development, each with particular developmental tasks. Cross-era transitions separate the eras. By describing and exploring the data according to this theory, Helen Keller as a profoundly handicapped person is shown to display universal patterns of development as suggested by Levinson. At the same time, the Life Structure she developed, her life components, and Satisfactoriness illuminated her uniqueness. Through the application of the theory to Helen Keller’s life, this psychobiographical study facilitated an examination of the theory. This led to suggestions for potential development of the theory.
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Barstad, Trenton A. "Lesbian family's developmental processes an extension of Carter and McGoldrick's model." CardinalScholar 1.0, 2009. http://liblink.bsu.edu/uhtbin/catkey/1536745.
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The purpose of this study was to examine whether current literature on the stages
of family developmental life cycles accurately describes the family and developmental
tasks for lesbian families. Due to the lack of empirical literature on this topic it was
important to examine the experiences of families headed by two women related to
developmental tasks experienced versus those proposed. Several authors have suggested
there may be differences between same-sex and opposite-sex parents in relation to
parenting styles and some child outcomes. However, none of these differences have been
studied within the framework of family developmental tasks. The purpose of the present
investigation was to explore the diversity of family structures, goals, and strategies within
families headed by two women. The present study collected data, explored the themes
related to families headed by two women who have children in the home who have not
yet entered school. The goal was to develop a theory from this data using Grounded
Theory which was compared with existing family developmental tasks theory and
proposed changes to existing theory to take into account expected differences lesbian
families may present.<br>Department of Counseling Psychology and Guidance Services
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Arosi, Ziyanda. "A psychobiographical study of Ellen Kuzwayo." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1008658.
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The current study is a psychobiography. The subject was chosen through purposive sampling based on the researcher’s personal interest and the remarkable impact this woman had within her society. Ellen Kuzwayo also meets the requirements of a psychobiography in that she is historically well known, inspirational, and her life has been completed. The study applies a qualitative research method in the form of a psychobiography, which aimed to describe Ellen Kuzwayo`s life accordingto Daniel Levinson`s Life Structure Theory of Adult Development. Levinson`s theory divides the lifespan into four developmental eras, each with its own biopsychosocial character. Each era in turn is divided into shorter periods of development. Levinson`s theory was chosenbecause it is specifically relevant to the development of women. The findings of the study indicate that Kuzwayo’s life was consistent with the pattern of development which Levinson (1996) identified. Kuzwayo was relatively successful in resolving the life tasks and transitional periods proposed by Levinson. This research study has given a positive demonstration of the value of development theory to investigate a particular human life. Furthermore, it emphasized the uniqueness of individuals in coping with the challenges of life. As a result it has opened up the possibility of perceiving people and their actions in a different way. Consequently, recommendations are offered in order to extend psychobiographical research on the life of Ellen Kuzwayo.
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Pavlíková, Stela. "Nanobezpečnost a současné trendy v hodnocení rizik nanočástic." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-414187.
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This diploma thesis deals with the current state of nanosafety. The aim of this paper was to review and critically analyze approaches to facilitate the risk assassment of nanomaterials. In the first part it provides an overview of the most important methods and software tools that are used in this field. Methods were analyzed against a set of relevant criteria. Criteria include consideration of exposure, life cycle and physicochemical properties, transparency, applicability and the field of application. Different criteria were chosen for the software tools. Based on results, a new approach was suggested. The approach takes the form of a diagram based on questions. The purpose of the suggested approach is to recommend the most relevant method, tool or their combination to assess the safety of a nanomaterial depending on known characteristics. The approach was also implemented in a software tool.
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Karianjahi, Muhia M. "Constructing Christian rites of passage that enhance community in East African churches." Online full text .pdf document, available to Fuller patrons only, 2003. http://www.tren.com.
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Tromp, Malou. "The environmental impact of introducing a potato protein for human consumption in Sweden." Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413595.
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In this study, a Consequential Life Cycle Assessment (CLCA) was conducted on the introduction of a potato protein for human consumption in Sweden. The assessed environmental impact cathegories in the CLCA were the categories global warming potential, eutrophication and land use. Potato protein is a side-stream that occurs during the production of potato starch and is currently used for animal feed (feed-grade). With the use of the new gene-editing technique CRISPR-Cas9, the stability of proteins in a starch potato can be improved to make the potato protein fit for human consumption (food-grade). The food-grade potato protein can be used as an ingredient in the food products: plant-based meat, quiche, sauces, wine and smoothies. When using the potato protein in one of these food products seven protein sources could potentially be substituted: soybean protein, yellow pea protein, beef protein, pork protein, chicken protein, egg protein and milk protein. The results of the CLCA show that when using the potato protein as an ingredient in a food product instead of other protein sources environmental impact can potentially be reduced. Most environmental impact can be reduced by substituting animal proteins by the potato protein. Therefore, from an environmental point of view, the most interesting food products to use the potato protein in as an ingredient are the food products where currently animal products are used in as the main source of protein.
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Schade, Susann [Verfasser], Gabriele I. [Gutachter] Stangl, and Martina [Gutachter] Gerken. "Distinct microalgae for human nutrition : comparative life cycle assessments and techno-economic analysis of microalgae cultivation ; [kumulative Dissertation] / Susann Schade ; Gutachter: Gabriele I. Stangl, Martina Gerken." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2020. http://d-nb.info/1220698180/34.
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Eliastam, Liesl Marijke. "A psychobiography of Archbishop Emeritus Desmond Mpilo Tutu." Thesis, University of Fort Hare, 2011. http://hdl.handle.net/10353/537.
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Psychobiographies offer the illuminating experience of uncovering the story of an individual’s life through the lens of a psychological theory. Psychobiographies offer the chance to gain a deeper understanding of what makes that individual unique. This study aimed to explore and describe the emotional intelligence of Archbishop Emeritus Desmond Tutu according to Goleman’s (1998) theory of Emotional Intelligence. Tutu was chosen as a subject for this study because of his extraordinary life and accomplishments, and because he is regarded as a prominent figure of moral leadership in South Africa. A qualitative psychobiographical research method was utilised. Data was collected from both primary and secondary sources to enhance internal validity, and was then analysed according to Miles and Huberman’s (1994) approach. The findings suggest that Tutu applied all of the twenty five emotional intelligence capacities during his life, and that at times, some were used more extensively than others. This study is groundbreaking in that it is the first psychobiography on Desmond Tutu, and it is the first psychobiography undertaken at the University of Fort Hare. Psychobiographies offer an opportunity to evaluate the psychological theory which is applied. It was found that Goleman’s (1998) theory of Emotional Intelligence is supported by this study.
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Fonteh, Pascaline Nanga. "Gold compounds with anti-HIV and immunomodulatory activity." Thesis, University of Pretoria, 2011. http://hdl.handle.net/2263/24951.
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The human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) that subsequently develops remain major health concerns even after three decades since the first cases were reported. Successful therapeutic measures to address HIV/AIDS consist mostly of combinations of drugs targeting viral enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) as well as entry steps of the viral life cycle. The remarkable benefits (e.g. improved quality of life) derived from the use of these agents are unfortunately limited by toxicity to the host and the development of drug resistant viral strains. Drug resistance limits the repertoire of drug combinations available. Unfortunately, because latent forms of the virus exists, therapy has to be life-long and with new infections occurring every day, resistant strains tend to spread. To circumvent these problems, new drugs that inhibit resistant strains or work against new viral targets have to be developed. The history of gold compounds as potential inhibitors of HIV prompted this study in which twenty seven compounds consisting of gold(I), gold(III) and precursors from five classes were tested for drug-likeness, anti-HIV and immunomodulatory effects using wet lab and in silico methodologies. Cytotoxicity determination was done using viability dyes and flow cytometry. Cell proliferation profiles were monitored using the carboxyflourescein succinimidyl ester dye dilution technology and a real time cell analyser for confirming viability dye findings. The compounds’ effects on viral enzymes was determined using direct enzyme assays and in silico molecular modelling techniques. H and P nuclear magnetic resonance spectroscopy studies for determining stability revealed that the backbone chemical shifts of the compounds were relatively unchanged after one week (-20 and 37 ºC) when dissolved in dimethylsulfoxide. Eight of the gold compounds had drug-like properties comparable to clinically available drugs when in silico predictions were performed. The 50% cytotoxic dose of the compounds in human cells was between 1 and 20 μM (clinically relevant concentrations for gold compounds). Three gold(I) compounds inhibited viral infectivity at non-toxic concentrations and two gold(III) compounds did so at cytostatic (anti-proliferative mechanism that is also antiviral) concentrations. In the immunomodulatory assay, cytokine levels were altered by five compounds with one gold(I) and a gold(III) compound significantly reducing the frequency of CD4+ cells (an anti-viral function) from HIV+ donors (p= 0.005 and 0.027 respectively) when multi-parametric flow cytometry was performed. Inhibition of RT activity was predicted in in silico studies to be through interactions with the ribonuclease (RNase) H site although with poor stereochemical orientation while favourable binding predictions with the IN cofactor binding site were observed for some gold(III) complexes. Compounds predicted to interact with the RNase H site of RT and the IN cofactor site require structural modification to improve drug-likeness and binding affinity. The drug-like compound(s) which inhibited viral infectivity and lowered CD4+ cell frequency have potential for incorporation into virostatic cocktails (combination of cytostatic and directly anti-viral agent). Cytostatic agents are known to be less prone to drug resistance and because they lower CD4+ cell frequency, such compounds can potentially limit HIV immune activation.<br>Thesis (PhD)--University of Pretoria, 2011.<br>Biochemistry<br>unrestricted