Relevant bibliographies by topics / Human Embryotoxicity

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Human Embryotoxicity'

Author: Grafiati
Published: 1 April 2023

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Journal articles on the topic "Human Embryotoxicity"

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Huxtable, Ryan J. "Human embryotoxicity of pyrrolizidine-containing drugs." Hepatology 9, no. 3 (March 1989): 510–11. http://dx.doi.org/10.1002/hep.1840090332.

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Aikawa, Nobuo, Atsushi Kunisato, Kenji Nagao, Hideaki Kusaka, Katsumi Takaba, and Kinya Ohgami. "Detection of Thalidomide Embryotoxicity by In Vitro Embryotoxicity Testing Based on Human iPS Cells." Journal of Pharmacological Sciences 124, no. 2 (2014): 201–7. http://dx.doi.org/10.1254/jphs.13162fp.

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Van Maele-Fabry, G., P. Therasse, E. Lenoir, J. P. Desager, K. Despontin, G. Gofflot, M. C. Jacobs, et al. "Embryotoxicity of human sera from patients treated with isotretinoin." Toxicology in Vitro 7, no. 6 (November 1993): 809–15. http://dx.doi.org/10.1016/0887-2333(93)90085-j.

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Walker, Lauren Michelle, Nicole R. L. Sparks, Veronica Puig-Sanvicens, Beatriz Rodrigues, and Nicole I. zur Nieden. "An Evaluation of Human Induced Pluripotent Stem Cells to Test for Cardiac Developmental Toxicity." International Journal of Molecular Sciences 22, no. 15 (July 29, 2021): 8114. http://dx.doi.org/10.3390/ijms22158114.

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To prevent congenital defects arising from maternal exposure, safety regulations require pre-market developmental toxicity screens for industrial chemicals and pharmaceuticals. Traditional embryotoxicity approaches depend heavily on the use of low-throughput animal models which may not adequately predict human risk. The validated embryonic stem cell test (EST) developed in murine embryonic stem cells addressed the former problem over 15 years ago. Here, we present a proof-of-concept study to address the latter challenge by updating all three endpoints of the classic mouse EST with endpoints derived from human induced pluripotent stem cells (hiPSCs) and human fibroblasts. Exposure of hiPSCs to selected test chemicals inhibited differentiation at lower concentrations than observed in the mouse EST. The hiPSC-EST also discerned adverse developmental outcomes driven by novel environmental toxicants. Evaluation of the early cardiac gene TBX5 yielded similar toxicity patterns as the full-length hiPSC-EST. Together, these findings support the further development of hiPSCs and early molecular endpoints as a biologically relevant embryotoxicity screening approach for individual chemicals and mixtures.
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Krtolica, Ana, Dusko Ilic, Olga Genbacev, and Richard K. Miller. "Human embryonic stem cells as a model for embryotoxicity screening." Regenerative Medicine 4, no. 3 (May 2009): 449–59. http://dx.doi.org/10.2217/rme.09.13.

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Rettie, Allan E., Albert W. Rettenmeier, Bruce K. Beyer, Thomas A. Baillie, and Mont R. Juchau. "Valproate hydroxylation by human fetal tissues and embryotoxicity of metabolites." Clinical Pharmacology and Therapeutics 40, no. 2 (August 1986): 172–77. http://dx.doi.org/10.1038/clpt.1986.160.

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Turkez, Hasan, Ozlem Ozdemir Tozlu, Arzu Tatar, Mehmet Enes Arslan, Kenan Cadirci, Lisa Marinelli, Omer Erkan Yapca, Ivana Cacciatore, Antonio Di Stefano, and Adil Mardinoglu. "Toxicity of Glycyl-l-Prolyl-l-Glutamate Pseudotripeptides: Cytotoxic, Oxidative, Genotoxic, and Embryotoxic Perspectives." Journal of Toxicology 2022 (November 19, 2022): 1–8. http://dx.doi.org/10.1155/2022/3775194.

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The tripeptide H-Gly-Pro-Glu-OH (GPE) and its analogs began to take much interest from scientists for developing effective novel molecules in the treatment of several disorders including Alzheimer’s disease, Parkinson’s disease, and stroke. The peptidomimetics of GPEs exerted significant biological properties involving anti-inflammatory, antiapoptotic, and anticancer properties. The assessments of their hematological toxicity potentials are critically required for their possible usage in further preclinical and clinical trials against a wide range of pathological conditions. However, there is so limited information on the safety profiling of GPE and its analogs on human blood tissue from cytotoxic, oxidative, and genotoxic perspectives. And, their embryotoxicity potentials were not investigated yet. Therefore, in this study, measurements of mitochondrial viability (using MTT assay) and lactate dehydrogenase (LDH) release as well as total antioxidant capacity (TAC) assays were performed on cultured human whole blood cells after treatment with GPE and its three novel peptidomimetics for 72 h. Sister chromatid exchange (SCE), micronucleus (MN), and 8-oxo-2-deoxyguanosine (8-OH-dG) assays were performed for determining the genotoxic damage potentials. In addition, the nuclear division index (NDI) was figured out for revealing their cytostatic potentials. Embryotoxicity assessments were performed on cultured human pluripotent NT2 embryonal carcinoma cells by MTT and LDH assays. The present results from cytotoxicity, oxidative, genotoxicity, and embryotoxicity testing clearly propounded that GPEs had good biosafety profiles and were trouble-free from the toxicological point of view. Noncytotoxic, antioxidative, nongenotoxic, noncytostatic, and nonembryotoxic features of GPE analogs are worthwhile exploring further and may exert high potentials for improving the development of novel disease-modifying agents.
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Delaroche, L., P. Oger, E. Genauzeau, P. Meicler, F. Lamazou, C. Dupont, and P. Humaidan. "Embryotoxicity testing of IVF disposables: how do manufacturers test?" Human Reproduction 35, no. 2 (February 2020): 283–92. http://dx.doi.org/10.1093/humrep/dez277.

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Abstract STUDY QUESTION How do manufacturers perform embryotoxicity testing in their quality control programs when validating IVF consumables? SUMMARY ANSWER The Mouse Embryo Assay (MEA) and Human Sperm Survival Assay (HSSA) used for IVF disposables differed from one manufacturer to another. WHAT IS KNOWN ALREADY Many components used in IVF laboratories, such as culture media and disposable consumables, may negatively impact human embryonic development. STUDY DESIGN, SIZE, DURATION Through a questionnaire-based survey, the main manufacturers of IVF disposable devices were contacted during the period November to December 2018 to compare the methodology of the MEA and HSSA. We focused on catheters for embryo transfer, catheters for insemination, straws, serological pipettes, culture dishes and puncture needles used in the ART procedures. PARTICIPANTS/MATERIALS, SETTING, METHODS We approached the manufacturers of IVF disposables and asked for details about methodology of the MEA and HSSA performed for toxicity testing of their IVF disposable devices. All specific parameters like mouse strains, number of embryos used, culture conditions (media, temperature, atmosphere), extraction protocol, subcontracting, and thresholds were registered and compared between companies. MAIN RESULTS AND THE ROLE OF CHANCE Twenty-one companies were approached, of which only 11 answered the questionnaire. Significant differences existed in the methodologies and thresholds of the MEA and HSSA used for toxicity testing of IVF disposables. Importantly, some of these parameters could influence the sensitivity of the tests. LIMITATIONS, REASONS FOR CAUTION Although we approached the main IVF manufacturers, the response rate was relatively low. WIDER IMPLICATIONS OF THE FINDINGS Our study confirms the high degree of heterogeneity of the embryotoxicity tests performed by manufacturers when validating their IVF disposable devices. Currently, no regulations exist on this issue. Professionals should call for and request standardization and a future higher degree of transparency as regards embryotoxicity testing from supplying companies; moreover, companies should be urged to provide the users clear and precise information about the results of their tests and how testing was performed. Future recommendations are urgently awaited to improve the sensitivity and reproducibility of embryotoxicity assays over time. STUDY FUNDING/COMPETING INTEREST(S) This study did not receive any funding. L.D. declares a competing interest with Patrick Choay SAS. TRIAL REGISTRATION NUMBER N/A
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Aikawa, N. "The development of in vitro embryotoxicity testing using human iPS cells." Toxicology Letters 295 (October 2018): S70. http://dx.doi.org/10.1016/j.toxlet.2018.06.521.

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Verma, Vinod, A. Mehta, and S. J. S. Flora. "Human Pluripotent Stem Cells and Drug Discovery: A New Beginning." Defence Life Science Journal 1, no. 1 (June 1, 2016): 27. http://dx.doi.org/10.14429/dlsj.1.10060.

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Human pluripotent stem cells (hPSCs) offer unique opportunities to discover and develop a new generation of drugs. Their ability to differentiate into virtually any cell type renders them a cost-effective, renewable source of tissue-specific cell types capable of predicting human responses towards novel chemical entities. Using these improved in vitro models based on physiologically relevant human cell types could result in identifying highly precise and safe compounds, thereby reducing drug attrition rates. Moreover, ability to develop humanised disease models for patient-stratified drug screening makes hPSCs an impeccable tool in translational medicine. In this mini-review we focus on the positives and negatives of utilising hPSC-derived cell types as drug discovery platforms with special emphasis on cardio-, hepato- and embryotoxicity.
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Dissertations / Theses on the topic "Human Embryotoxicity"

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Al-Rubai, Abdal-jabbar. "Human neural stem cell culture and other in vitro model for prediction of embryotoxicity and neurotoxicity." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33765/.

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Generally, most of the in vitro tests used in neurotoxicology are limited to transformed cell lines which are derived from rodent or human. For an in vitro test to have high rate of predictability of neurotoxicity and teratogenicity it should undergo the important processes of embryological development, such as cell proliferation, cell migration, and differentiation. Human neural stem cells have been proposed for this purpose, which have the ability to divide, differentiate, and migrate. In this study, it was found that double coating of laminin with either poly D lysine or poly L lysine was most suitable for growing human neural stem cells rather than coating with a single extracellular molecule. Several chemicals and drugs were then chosen to assess the utility of neural stem cells as an assay for neurotoxicity: methyl mercury and lead acetate; four anti-epileptics drugs (sodium valproate, phenytoin, carbamazepine, and phenobarbitone); anti-oxidants (folic acid and melatonin). These anti-oxidants were tested alone and when added to sodium valproate and to phenytoin (which are well known in their teratogenicity), and other drugs (lithium, diazepam, and amitriptyline), which are weak teratogens. To assess the effects of these molecules on human neural stem cells cell survival, total cellular protein, neuronal process length, neurosphere sizes, migration distance, Glial Fibrillary Acidic Protein, and tubulin III protein expression were measured. The study shows that methyl mercury caused significant reduction in most of the end points from the dose of 1µM and it led to significant increase in Glial Fibrillary Acidic Protein expression (which is a sign of reactive gliosis). Lead acetate led to a significant reduction in cell migration 48hours after treatment with 10µM. In the case of the anti-epileptics, sodium valproate appeared to reduce neurosphere size significantly from the dose of 500µM and decrease migration distance significantly 48hours after treatment with 1000µM. Moreover, phenytoin treatment resulted in significant reduction in neurosphere sizes from the dose of 25µM and reduced cell migration significantly from the dose of 50µM. However, the other anti-epileptics (carbamazepine and phenobarbitone) revealed their effect only at high doses which are above their therapeutic range. On the other hand, adding the anti-oxidants (Folic acid or Melatonin) to sodium valproate or phenytoin had to some extent beneficial effects, by making their toxic effect appear at doses which were higher than when used alone. Regarding the other drugs (lithium, diazepam, and amitriptyline), it seems that their toxic effect appeared only at doses which are higher than the therapeutic range. Therefore, it can be concluded that human neural stem cells are a sensitive model in detecting the neurotoxicity of methyl mercury and lead acetate at low doses and can predict the neurotoxicity of sodium valproate and phenytoin at their therapeutic doses.
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Alvarenga, Cláudia Maria Domingues. "Avaliação dos mecanismos de ação interceptiva e/ou embriotóxica do extrato aquoso de Plectranthus barbatus Andr.(bolbo-brasileiro) administrado a ratas prenhez no período de pré-implantação /." Botucatu : [s.n.], 2006. http://hdl.handle.net/11449/104597.

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Orientador: Ione Pellegatti Lemonica
Banca: João Lauro Viana de Camargo
Banca: Márcia Guimarães da Silva
Banca: Silvana Lima Górniak
Banca: Regiane Kawakami
Tese não possui um resumo geral, possue um resumo para cada capítulo
Resumo : O objetivo do presente estudo foi verificar, experimentalmente, o possível mecanismo pelo qual o extrato aquoso de Plectranthus barbatus (boldo-brasileiro), planta utilizada popularmente como abortiva, atua sobre o organismo materno ou sobre o desenvolvimento do concepto durante o período de pré-implantação, correlacionando sua ingestão com possíveis alterações no transporte e desenvolvimento embrionário ou com alterações hormonais maternas...(Resumo completo, clicar acesso eletrônico abaixo)
Abstract : The present study was conducted to determine the possible mechanism by which the aqueous extract of Plectranthus barbatus (brazilian-boldo), a plant used popularly as abortive agent, can lead to early loss of pregnancy, correlating this possible effect with morphological alterations in the embryo, oviductal motility dysfunctions or maternal hormonal level modifications...(Complete abstract, access undermentioned electronic address)
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3

Alvarenga, Cláudia Maria Domingues [UNESP]. "Avaliação dos mecanismos de ação interceptiva e/ou embriotóxica do extrato aquoso de Plectranthus barbatus Andr.(bolbo-brasileiro) administrado a ratas prenhez no período de pré-implantação." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/104597.

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Made available in DSpace on 2014-06-11T19:33:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-08-24Bitstream added on 2014-06-13T18:45:06Z : No. of bitstreams: 1 alvarenga_cmd_dr_botfm_prot.pdf: 1786103 bytes, checksum: 14d9f0d294fb6c639b79eab0f8e823c6 (MD5)
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O objetivo do presente estudo foi verificar, experimentalmente, o possível mecanismo pelo qual o extrato aquoso de Plectranthus barbatus (boldo-brasileiro), planta utilizada popularmente como abortiva, atua sobre o organismo materno ou sobre o desenvolvimento do concepto durante o período de pré-implantação, correlacionando sua ingestão com possíveis alterações no transporte e desenvolvimento embrionário ou com alterações hormonais maternas...
The present study was conducted to determine the possible mechanism by which the aqueous extract of Plectranthus barbatus (brazilian-boldo), a plant used popularly as abortive agent, can lead to early loss of pregnancy, correlating this possible effect with morphological alterations in the embryo, oviductal motility dysfunctions or maternal hormonal level modifications...(Complete abstract, access undermentioned electronic address)
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Book chapters on the topic "Human Embryotoxicity"

1

Winn, Louise M., and Emily W. Y. Tung. "Assessment of Embryotoxicity Using Mouse Embryo Culture." In Human Embryogenesis, 241–49. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-009-0_15.

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