Relevant bibliographies by topics / Human Embryotoxicity

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Human Embryotoxicity'

Author: Grafiati
Published: 1 April 2023

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Journal articles on the topic "Human Embryotoxicity"

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Huxtable, Ryan J. "Human embryotoxicity of pyrrolizidine-containing drugs." Hepatology 9, no. 3 (1989): 510–11. http://dx.doi.org/10.1002/hep.1840090332.

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Aikawa, Nobuo, Atsushi Kunisato, Kenji Nagao, Hideaki Kusaka, Katsumi Takaba, and Kinya Ohgami. "Detection of Thalidomide Embryotoxicity by In Vitro Embryotoxicity Testing Based on Human iPS Cells." Journal of Pharmacological Sciences 124, no. 2 (2014): 201–7. http://dx.doi.org/10.1254/jphs.13162fp.

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Van Maele-Fabry, G., P. Therasse, E. Lenoir, et al. "Embryotoxicity of human sera from patients treated with isotretinoin." Toxicology in Vitro 7, no. 6 (1993): 809–15. http://dx.doi.org/10.1016/0887-2333(93)90085-j.

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Walker, Lauren Michelle, Nicole R. L. Sparks, Veronica Puig-Sanvicens, Beatriz Rodrigues, and Nicole I. zur Nieden. "An Evaluation of Human Induced Pluripotent Stem Cells to Test for Cardiac Developmental Toxicity." International Journal of Molecular Sciences 22, no. 15 (2021): 8114. http://dx.doi.org/10.3390/ijms22158114.

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To prevent congenital defects arising from maternal exposure, safety regulations require pre-market developmental toxicity screens for industrial chemicals and pharmaceuticals. Traditional embryotoxicity approaches depend heavily on the use of low-throughput animal models which may not adequately predict human risk. The validated embryonic stem cell test (EST) developed in murine embryonic stem cells addressed the former problem over 15 years ago. Here, we present a proof-of-concept study to address the latter challenge by updating all three endpoints of the classic mouse EST with endpoints de
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Krtolica, Ana, Dusko Ilic, Olga Genbacev, and Richard K. Miller. "Human embryonic stem cells as a model for embryotoxicity screening." Regenerative Medicine 4, no. 3 (2009): 449–59. http://dx.doi.org/10.2217/rme.09.13.

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Rettie, Allan E., Albert W. Rettenmeier, Bruce K. Beyer, Thomas A. Baillie, and Mont R. Juchau. "Valproate hydroxylation by human fetal tissues and embryotoxicity of metabolites." Clinical Pharmacology and Therapeutics 40, no. 2 (1986): 172–77. http://dx.doi.org/10.1038/clpt.1986.160.

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Turkez, Hasan, Ozlem Ozdemir Tozlu, Arzu Tatar, et al. "Toxicity of Glycyl-l-Prolyl-l-Glutamate Pseudotripeptides: Cytotoxic, Oxidative, Genotoxic, and Embryotoxic Perspectives." Journal of Toxicology 2022 (November 19, 2022): 1–8. http://dx.doi.org/10.1155/2022/3775194.

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The tripeptide H-Gly-Pro-Glu-OH (GPE) and its analogs began to take much interest from scientists for developing effective novel molecules in the treatment of several disorders including Alzheimer’s disease, Parkinson’s disease, and stroke. The peptidomimetics of GPEs exerted significant biological properties involving anti-inflammatory, antiapoptotic, and anticancer properties. The assessments of their hematological toxicity potentials are critically required for their possible usage in further preclinical and clinical trials against a wide range of pathological conditions. However, there is
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Delaroche, L., P. Oger, E. Genauzeau, et al. "Embryotoxicity testing of IVF disposables: how do manufacturers test?" Human Reproduction 35, no. 2 (2020): 283–92. http://dx.doi.org/10.1093/humrep/dez277.

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Abstract STUDY QUESTION How do manufacturers perform embryotoxicity testing in their quality control programs when validating IVF consumables? SUMMARY ANSWER The Mouse Embryo Assay (MEA) and Human Sperm Survival Assay (HSSA) used for IVF disposables differed from one manufacturer to another. WHAT IS KNOWN ALREADY Many components used in IVF laboratories, such as culture media and disposable consumables, may negatively impact human embryonic development. STUDY DESIGN, SIZE, DURATION Through a questionnaire-based survey, the main manufacturers of IVF disposable devices were contacted during the
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Aikawa, N. "The development of in vitro embryotoxicity testing using human iPS cells." Toxicology Letters 295 (October 2018): S70. http://dx.doi.org/10.1016/j.toxlet.2018.06.521.

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Verma, Vinod, A. Mehta, and S. J. S. Flora. "Human Pluripotent Stem Cells and Drug Discovery: A New Beginning." Defence Life Science Journal 1, no. 1 (2016): 27. http://dx.doi.org/10.14429/dlsj.1.10060.

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Human pluripotent stem cells (hPSCs) offer unique opportunities to discover and develop a new generation of drugs. Their ability to differentiate into virtually any cell type renders them a cost-effective, renewable source of tissue-specific cell types capable of predicting human responses towards novel chemical entities. Using these improved in vitro models based on physiologically relevant human cell types could result in identifying highly precise and safe compounds, thereby reducing drug attrition rates. Moreover, ability to develop humanised disease models for patient-stratified drug scre
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Dissertations / Theses on the topic "Human Embryotoxicity"

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Al-Rubai, Abdal-jabbar. "Human neural stem cell culture and other in vitro model for prediction of embryotoxicity and neurotoxicity." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33765/.

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Generally, most of the in vitro tests used in neurotoxicology are limited to transformed cell lines which are derived from rodent or human. For an in vitro test to have high rate of predictability of neurotoxicity and teratogenicity it should undergo the important processes of embryological development, such as cell proliferation, cell migration, and differentiation. Human neural stem cells have been proposed for this purpose, which have the ability to divide, differentiate, and migrate. In this study, it was found that double coating of laminin with either poly D lysine or poly L lysine was m
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Alvarenga, Cláudia Maria Domingues. "Avaliação dos mecanismos de ação interceptiva e/ou embriotóxica do extrato aquoso de Plectranthus barbatus Andr.(bolbo-brasileiro) administrado a ratas prenhez no período de pré-implantação /." Botucatu : [s.n.], 2006. http://hdl.handle.net/11449/104597.

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Orientador: Ione Pellegatti Lemonica<br>Banca: João Lauro Viana de Camargo<br>Banca: Márcia Guimarães da Silva<br>Banca: Silvana Lima Górniak<br>Banca: Regiane Kawakami<br>Tese não possui um resumo geral, possue um resumo para cada capítulo<br>Resumo : O objetivo do presente estudo foi verificar, experimentalmente, o possível mecanismo pelo qual o extrato aquoso de Plectranthus barbatus (boldo-brasileiro), planta utilizada popularmente como abortiva, atua sobre o organismo materno ou sobre o desenvolvimento do concepto durante o período de pré-implantação, correlacionando sua ingestão com poss
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Alvarenga, Cláudia Maria Domingues [UNESP]. "Avaliação dos mecanismos de ação interceptiva e/ou embriotóxica do extrato aquoso de Plectranthus barbatus Andr.(bolbo-brasileiro) administrado a ratas prenhez no período de pré-implantação." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/104597.

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Made available in DSpace on 2014-06-11T19:33:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-08-24Bitstream added on 2014-06-13T18:45:06Z : No. of bitstreams: 1 alvarenga_cmd_dr_botfm_prot.pdf: 1786103 bytes, checksum: 14d9f0d294fb6c639b79eab0f8e823c6 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O objetivo do presente estudo foi verificar, experimentalmente, o possível mecanismo pelo qual o extrato aquoso de Plectranthus barbatus (boldo-brasileiro), planta utilizada popularmente como abortiva, atua sobre o organismo materno ou sobre o desenvolvime
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Book chapters on the topic "Human Embryotoxicity"

1

Winn, Louise M., and Emily W. Y. Tung. "Assessment of Embryotoxicity Using Mouse Embryo Culture." In Human Embryogenesis. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-009-0_15.

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