Dissertations / Theses on the topic 'Human bioactivity'
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Ferruzzi, Mario G. "Digestive stability, human intestinal cell uptake, and bioactivity of dietary chlorophyll derivatives /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394475978215.
Full textYateman, Martin Edward. "Regulation of human fibroblast insulin-like growth factor (IGF)-binding proteins by IGF-1 and cytokines, mechanisms of action and effects upon IGF bioactivity." Thesis, Queen Mary, University of London, 1995. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1742.
Full textDe, Araújo Júnior José Vitor. "Chitosan/carrageenan-based polyelectrolyte complexes and their composites with calcium phosphate for bone tissue engineering." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608264.
Full textAor, Bruno. "Engineering microchannels for vascularization in bone tissue engineering." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0430/document.
Full textIn vitro, tubular-like structures formation with human umbilical vein endothelial cells (HUVECs) was investigated by combining material chemistry functionalization and three-dimensional geometry development. Polycarbonate (PC) was used as a template for the development of the scaffold. Natural polysaccharide’s film based on alternate layer-by-layer (LbL) deposition of hyaluronic acid (HA) and chitosan (CHI), was first applied to PC surface and characterized in terms of thickness growth both, in dry conditions using ellipsometry, and confocal lascar scanning microscopy (CLSM). This first functionalization results in a complete coating of the PC layer. Further biofunctionalization with one adhesive peptide (RGD) and two angiogenetic peptides (SVV and QK) was investigated, immobilizing those peptides on the carboxylic group of HA previously deposited, using the well-known carbodiimide chemistry. The labeled version of each peptide was used to characterize the peptides’ immobilization and penetration into the polyelectrolytes layers, resulting in a successful grafting with complete penetration through the entire thickness of the LbL. In vitro tests were performed using HUVECs to assess their adhesion efficiency and their metabolic activity on the LbL with and without peptide immobilization, resulting in a preliminary improved activity when peptide-combinations is used. Finally, PC micro-channels (μCh) were first developed and characterized, and the rest of the experiments were performed on μCh of 25μm width, functionalized with (HA/CHI)12.5 architecture (PC-LbL) with RGD and QK peptides (PC-RGD+QK) or with RGD and SVV peptides (PC-RGD+SVV). Our first tubulogenesis experiment surprisingly showed the formation of tubular-like structures already after 2h of incubation using the double-peptides combination but only using PC-RGD+QK the tubes were present also after 3 and 4 hours of culture. The co-culture experiment with human pericytes derived from placenta (hPC-PL) demonstrates how the stabilization of the tubes was improved after 3 and 4 hours also for the PC-RGD+SVV sample. Globally our bio-functional material with PC-RGD+QK and PC-RGD+SVV peptides allow the formation of tubular-like structure in both mono and co-culture experiment
Hamill, Lesley L. "Whole grain components : bioavailability and bioactivity in humans." Thesis, University of Ulster, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554200.
Full textDe, Ferrars Rachel. "The metabolic fate and bioactivity of anthocyanins in humans." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/49475/.
Full textTaylor, Alistair Michael. "Bioactivity of the insulin-like growth factors in normal and diabetic humans and rats." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266647.
Full textWilliamson, Kelly Scott. "Pharmacology, epidemiology, and bioactivites of tocopherols and their metabolites in human and non-human models for inflammatory disease." Oklahoma City : [s.n.], 2008.
Find full textBen, Henda Yesmine. "Bioactivités de cryptides marins : quels potentiels pour la santé humaine ?" Thesis, La Rochelle, 2014. http://www.theses.fr/2014LAROS032/document.
Full textMarine products represent an important source of active substances, in particular bioactive peptides called cryptides. Cryptides are hidden within the sequence of a parent protein and are released during digestion or industrial proteolytic processes. These cryptides could provide physiological benefit or protection against diseases such as those of metabolic syndrome. In this context, we investigated the action of some marine cryptides on hypertension, diabetes and obesity. We demonstrated that some cryptides can target in vitro several factors associated with the development of metabolic syndrome
Faure, Dominique. "Dégradation du facteur natriurétique auriculaire humain in vitro et in vivo : immunoréactivité et bioactivité des fragments de dégradation chez le sujet sain et pathologique." Bordeaux 2, 1996. http://www.theses.fr/1996BOR28420.
Full textWang, Chien-Yu, and 王倩俁. "Analysis of Bioactivity and Functional Genomic Effect of Phytocompounds from Echinacea on human Dendritic cells." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/50828058472401159387.
Full text國立臺灣大學
植物學研究所
91
Abstract : Echinacea spp. is widely and heavily used as a medicinal herb or food supplement for stimulating immune function in many American and European countries. Three major species have been studied for candidate bioactivity in pharmacological and immunological effects, e.g., on macrophages or other immune cells. However, little or no evidence has been reported for possible effects of Echinacea on dendritic cells (DC). Dendritic cells are professional antigen-presentation cells (APC) and play an important role in innate as well as adaptive immunities. In this study, we analyzed the immune-associated surface proteins (CD markers) and the differential gene/genomic expression patterns of dendritic cells treated with or without Echinacea extract, using flow cytometry and DNA microarray techniques. Our preliminary results show that Echinacea root extract apparently can stimulate the expression of CD83 in dendritic cells with or without co-treatment with lipopolysaccharide. On the other hand, when treated with Echinacea stem plus leaf extract, CD83 expression apparently get inhibited. Furthermore, by using a home-made, mini-DNA microarray ( containing 225 genes) analysis system, we have been able to detect distinct patterns for the expression of specific immune or other functional activity associated mRNA species. About 10 genes, including those encoding NAFTp, IL-7R, Cybr, Jun, MCP-1, ICAM-1, Erm, Wnt-1, CCR-1 and CCR-9, were up- or down-regulated within 4 to 16 h post treatment. Since this mini-chip genes were selected and organized for immune related or other known functions, bioinformatics analyses are being carried out to evaluate these responsive genes for possible significance in immune or cellular-signaling mechanisms. Previous studies reputed that Echinacea may be associated with anti-inflammatory activity. We show in this study that Echinacea can stimulate or suppress certain specific activities of dendritic cells at the gene and/or protein expression level. In addition, based on these results and leads, bioactivity-guided assays of specific phytocompounds from this medicinal herb can now be systematically tested, by bio-organic partition/fractionation, for identifying phytocompound groups, single compounds or reconstituted formulations from Echinacea plant extracts as candidate therapeutics or health care supplements.
Snyder, Dawn. "Raspberries and Human Health: A Clinical Perspective on the Bioactivity and Bioavailability of Red Raspberry Antioxidants." Thesis, 2012. http://hdl.handle.net/1807/33687.
Full textAraújo, Lucas Quintino da Silva. "Expression, Purification and Stability Study of the Recombinant Human Interferon α-2b." Master's thesis, 2016. http://hdl.handle.net/10362/76560.
Full textChiang, Yu Ling, and 蔣裕玲. "Bioactivity of active ingredient in dietary seasonings --Rosmarinic acid(I)Inhibition on invasive activity of human colorectal carcinoma cells(II)Inhibitory effect and mechanism on multiple-drug resistant Mycobacterium tuberculosis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/81873134553699820316.
Full text台南應用科技大學
生活應用科學研究所
100
(I) Colorectal cancer is the leading cause of cancer mortality, and metastasis is responsible for approximately 40% of death in colon cancer patients. Matrix metalloproteinases (MMPs) are key enzymes in the degradation of extracellular matrix, and MMP-2 and -9 are critical for cell migration leading to invasion and metastasis of cancer. The inhibition of MMP-2 and -9 is therefore considered that might depress the occurrence of tumor invasion and metastasis. Rosmarinic acid (RA) is a bioactive polyphenol that widely presented in Rosmarinus officinalis L. However, the literature regarding the effect of RA on invasion of cancer cells is still limited. In this study, we investigated the anti-invasion activity of RA against human colorectal adenocarcinoma Colo205 and HT-29 cells. The cells were treated with 0, 10, 50, 100, or 200 M of RA at 37C for 24 h, and the MMP-2, -9, and uPA activities as well as cell-matrix adhesion, motility, and invasion activities were determined. The MMP-2, -9, TIMP-1 and -2 mRNA levels were assayed by RT-PCR. The molecular signaling was determined by Weastern blot. The results showed that the MMP-2 and uPA activities of Colo205 and HT-29 cells were significantly inhibited by RA at a concentration of > 50 μM. The migration and invasion activities of Colo205 and HT-29 cells were also suppressed after treating with RA at a concentration higher than 50 M. The mRNA level of MMP-2 in HT-29 and Colo205 were significantly inhibited by RA at a concentration of > 50 M. The mRNA levels of TIMP-1 and -2 in HT-29 and TIMP-1 in Colo205 were significantly increased by RA. The signaling of p-ERK and p-p38 in Colo205 and HT-29 were signigicantly inhibited by RA. Furthermore, the activations of NF-κB and AP-1 in colorectal cancer cells were also suppressed by RA. Our results suggest that RA might be a bioactive with potential anti-invasive activity against colorectal cancer cells by inhibiting uPA and MMP-2 activity and reducing motility capabilities through inhibiting the activations of MAPKs signaling pathways and NF-κB and AP-1 transcription factors. (II) Tuberculosis (TB) is a contagious disease which causes a serious public health risk. WHO estimates that there were approximately 9,400,000 new TB cases globally in 2008, and South-East Asia Region accounted for 34% of incident cases. Multidrug-resistant TB (MDR-TB) is a particularly dangerous form of TB, which is responsible for the majority of failures in TB therapy. Mycobacterium tuberculosis is the major pathogeny of TB, and uridine diphosphate-glucose pyrophosphorylase (UGPase; EC 2.7.7.9) is the major enzyme that involved to the synthesis of cell wall. The inhibition of UGPase might depress the proliferation of the bacilli. Rosmarinic acid (RA), a polyphenol which is widely presented in natural plants of Lamiaceae and Boraginaceae family, has been reported that possesses several biological activities such as anti-virus, anti-inflammation, and anti-bacteria. The aim of this study was to investigate the inhibitory effects of RA on the viability of multidrug-resistant M. tuberculosis, and their impact on UGPase was also evaluated. Because the biological activity of a bioactive sometimes having an association with their antioxidant power, we therefore first determined the antioxidant activity of RA by trolox equivalent antioxidant capacity (TEAC) method. The viability of the bacilli was measured by counting the colony growing on 7H11 agar plates, and the expression of UGPase was performed by RT-PCR. The results showed RA having a strong antioxidant activity, and the viability of M. tuberculosis was reduced by treating with RA at a concentration of > 250 g/ml for 24 h. Furthermore, the expression of UGPase was also decreased by treating with 250 g/ml RA for 24 h. Based on the data mentioned above, it is suggested that RA can be used to inhibit the proliferation of multidrug-resistant M. tuberculosis, and the anti-proliferous activity of RA might be through inhibiting the expression of UGPase.
Chiang, Yu-Ling, and 蔣裕玲. "Bioactivity of active ingredient in dietary seasonings --Rosmarinic acid(I) Inhibition on invasive activity of human colorectal carcinoma cells(II) Inhibitory effect and mechanism on multiple-drug resistant Mycobacterium tuberculosis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/35663803510360707953.
Full text台南應用科技大學
生活應用科學研究所
100
(I) Colorectal cancer is the leading cause of cancer mortality, and metastasis is responsible for approximately 40% of death in colon cancer patients. Matrix metalloproteinases (MMPs) are key enzymes in the degradation of extracellular matrix, and MMP-2 and -9 are critical for cell migration leading to invasion and metastasis of cancer. The inhibition of MMP-2 and -9 is therefore considered that might depress the occurrence of tumor invasion and metastasis. Rosmarinic acid (RA) is a bioactive polyphenol that widely presented in Rosmarinus officinalis L. However, the literature regarding the effect of RA on invasion of cancer cells is still limited. In this study, we investigated the anti-invasion activity of RA against human colorectal adenocarcinoma Colo205 and HT-29 cells. The cells were treated with 0, 10, 50, 100, or 200 M of RA at 37C for 24 h, and the MMP-2, -9, and uPA activities as well as cell-matrix adhesion, motility, and invasion activities were determined. The MMP-2, -9, TIMP-1 and -2 mRNA levels were assayed by RT-PCR. The molecular signaling was determined by Weastern blot. The results showed that the MMP-2 and uPA activities of Colo205 and HT-29 cells were significantly inhibited by RA at a concentration of > 50 μM. The migration and invasion activities of Colo205 and HT-29 cells were also suppressed after treating with RA at a concentration higher than 50 M. The mRNA level of MMP-2 in HT-29 and Colo205 were significantly inhibited by RA at a concentration of > 50 M. The mRNA levels of TIMP-1 and -2 in HT-29 and TIMP-1 in Colo205 were significantly increased by RA. The signaling of p-ERK and p-p38 in Colo205 and HT-29 were signigicantly inhibited by RA. Furthermore, the activations of NF-κB and AP-1 in colorectal cancer cells were also suppressed by RA. Our results suggest that RA might be a bioactive with potential anti-invasive activity against colorectal cancer cells by inhibiting uPA and MMP-2 activity and reducing motility capabilities through inhibiting the activations of MAPKs signaling pathways and NF-κB and AP-1 transcription factors. (II) Tuberculosis (TB) is a contagious disease which causes a serious public health risk. WHO estimates that there were approximately 9,400,000 new TB cases globally in 2008, and South-East Asia Region accounted for 34% of incident cases. Multidrug-resistant TB (MDR-TB) is a particularly dangerous form of TB, which is responsible for the majority of failures in TB therapy. Mycobacterium tuberculosis is the major pathogeny of TB, and uridine diphosphate-glucose pyrophosphorylase (UGPase; EC 2.7.7.9) is the major enzyme that involved to the synthesis of cell wall. The inhibition of UGPase might depress the proliferation of the bacilli. Rosmarinic acid (RA), a polyphenol which is widely presented in natural plants of Lamiaceae and Boraginaceae family, has been reported that possesses several biological activities such as anti-virus, anti-inflammation, and anti-bacteria. The aim of this study was to investigate the inhibitory effects of RA on the viability of multidrug-resistant M. tuberculosis, and their impact on UGPase was also evaluated. Because the biological activity of a bioactive sometimes having an association with their antioxidant power, we therefore first determined the antioxidant activity of RA by trolox equivalent antioxidant capacity (TEAC) method. The viability of the bacilli was measured by counting the colony growing on 7H11 agar plates, and the expression of UGPase was performed by RT-PCR. The results showed RA having a strong antioxidant activity, and the viability of M. tuberculosis was reduced by treating with RA at a concentration of > 250 g/ml for 24 h. Furthermore, the expression of UGPase was also decreased by treating with 250 g/ml RA for 24 h. Based on the data mentioned above, it is suggested that RA can be used to inhibit the proliferation of multidrug-resistant M. tuberculosis, and the anti-proliferous activity of RA might be through inhibiting the expression of UGPase.
Egaña, Erazo José Tomás [Verfasser]. "Use of human mesenchymal cells to bioactivate scaffolds for dermal regeneration in vitro and in vivo / vorgelegt von José Tomás Egaña Erazo." 2008. http://d-nb.info/991532015/34.
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