Relevant bibliographies by topics / Human bioactivity

Academic literature on the topic 'Human bioactivity'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Human bioactivity"

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Simpson, B. J. B., C. G. Tsonis, and F. C. W. Wu. "INHIBIN BIOACTIVITY IN HUMAN TESTICULAR EXTRACTS." Journal of Endocrinology 115, no. 2 (November 1987): R9—R12. http://dx.doi.org/10.1677/joe.0.115r009.

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ABSTRACT Inhibin bioactivity was measured in human testicular extracts by a sensitive sheep pituitary cell bioassay. The relationship between testicular inhibin bioactivity, daily sperm production (DSP) and plasma concentrations of FSH, LH, testosterone and oestradiol were examined. The mean level of testicular inhibin bioactivity was 4.4 ±1.3 U/g (mean ± SD) with a significantly lower value in those who received radiotherapy (3.2 ± 1.4 U/g) than in the untreated group (4.8 ± 1.1 U/g). In contrast to the rat, human testicular inhibin bioactivity was not significantly correlated to FSH or DSP. These findings suggest that inhibin may have a complex role in normal and/or pathological testicular function.
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De Aza, P. N., Z. B. Luklinska, M. R. Anseau, F. Guitian, and S. De Aza. "Bioactivity of pseudowollastonite in human saliva." Journal of Dentistry 27, no. 2 (February 1999): 107–13. http://dx.doi.org/10.1016/s0300-5712(98)00029-3.

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Katlinski, Kanstantsin, Sviatlana Akalovich, Yuliya Katlinskaya, Anton Sholukh, Tatyana Doroshenko, Yury Chaly, and Nikolai N. Voitenok. "Soluble human CXCR2: Structure, properties, bioactivity." Cytokine 48, no. 1-2 (October 2009): 2. http://dx.doi.org/10.1016/j.cyto.2009.07.377.

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Katlinski, Kanstantsin, Sviatlana Akalovich, Yuliya Katlinskaya, Anton Sholukh, Tatyana Doroshenko, Yury Chaly, and Nikolai N. Voitenok. "Soluble human CXCR2: Structure, properties, bioactivity." Cytokine 48, no. 1-2 (October 2009): 102. http://dx.doi.org/10.1016/j.cyto.2009.07.431.

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Page, S. R., A. H. Taylor, W. Driscoll, M. Baines, R. Thorpe, A. P. Johnstone, S. S. Nussey, and G. St J. Whitley. "Modulation of the biological activity of thyrotrophin by anti-human thyrotrophin monoclonal antibodies." Journal of Endocrinology 126, no. 2 (August 1990): 333–40. http://dx.doi.org/10.1677/joe.0.1260333.

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ABSTRACT The mechanism by which monoclonal antibodies enhance the biological activity of a number of hormones is poorly understood. One such antibody (GC73), which binds to human but not bovine TSH, enhances the bioactivity of human TSH in vivo. We have investigated whether GC73 enhancement of TSH bioactivity involves potentiation of hormone-receptor activation assessed by the cyclic AMP (cAMP) responses of both primary human thyrocyte cultures and a TSH-responsive human thyrocyte cell line (SGHTL-45). GC73 had no effect on basal cAMP production. In contrast to its enhancement of the bioactivity of human TSH in vivo, it markedly inhibited the cAMP response to 1 and 10 mU human TSH/ml in primary thyrocytes. This effect was dose-dependent with neutralization of the bioactivity of TSH occurring at 2 mg GC73/ml. GC73 had no effect on the bioactivity of bovine TSH. In contrast, a second anti-TSH monoclonal antibody (TC12), which binds to both human and bovine TSH, inhibited the bioactivity of both species of TSH. Similar results were obtained using SGHTL-45 cells, although the peak concentrations of cAMP were lower. We conclude that binding of GC73 to human TSH resulted in inhibition rather than enhancement of the in-vitro biological activity of human TSH. We suggest that GC73 enhancement of human TSH bioactivity seen in vivo does not result from a mechanism involving potentiation of receptor activation by human TSH. Journal of Endocrinology (1990) 126, 333–340
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Ackland, J. F., S. J. Ratter, G. L. Bourne, and L. H. Rees. "Corticotrophin-releasing factor-like immunoreactivity and bioactivity of human fetal and adult hypothalami." Journal of Endocrinology 108, no. 2 (February 1986): 171–80. http://dx.doi.org/10.1677/joe.0.1080171.

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ABSTRACT Corticotrophin releasing factor-like immunoreactivity (CRF-LI) and bioactivity, and arginine vasopressinlike immunoreactivity (AVP-LI) have been measured in extracts of human fetal and adult hypothalamic tissue and their development with the gestational age of the fetuses (12–27 weeks) studied. CRF-LI was measured by a radioimmunoassay developed for ovine corticotrophin-releasing factor (oCRF-41). Corticotrophin-releasing factor bioactivity was measured in a rat isolated anterior pituitary cell perfusion system. CRF-LI and bioactivity and AVP-LI were all detectable in fetal hypothalamic extracts from 12 to 13 weeks of gestational age. CRF-LI was also present in human fetal pituitary glands from 12 weeks of gestational age. The concentration of CRF-LI in the fetal hypothalamic extracts (9·2±11·4 ng/g, mean ± s.e.m., n = 33) showed no significant correlation with the gestational age of the fetuses. However the concentration of AVP-LI (25·0–36·8 ng/g, n = 17) did show a positive correlation (r = 0·508, P<0·05) with gestational age, as did the concentration of CRF bioactivity (471·3–556·3 ng ACTH released/g tissue, n = 13, r = 0·725, P < 0·01). The CRF bioactivity of all fetal hypothalamic extracts was potentiated by the addition of synthetic human (h)AVP, but the bioactivity of the adult hypothalamic extracts was not, presumably because of the higher levels of AVP-LI already present in the adult extracts. Pretreatment of tissue extracts with antisera to oCRF-41 and/or hAVP reduced the CRF bioactivity of all hypothalamic extracts. Sephadex chromatography of fractions which co-eluted with synthetic oCRF-41 or hAVP contained CRF bioactivity and this bioactivity was potentiated when synthetic hAVP or oCRF-41, respectively, were added to the fractions. However, a larger molecular weight form of CRF-LI (8000–10 000 daltons), which was observed only in fetuses of 20 weeks of gestational age or less, did not contain any significant CRF bioactivity. J. Endocr. (1986) 108, 171–180
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Fukushima, Naobumi, Kanji Nagashima, and Takayoshi Kuroume. "Fibronectin Synthesis Bioactivity in Human Breast Milk." Neonatology 65, no. 2 (1994): 77–84. http://dx.doi.org/10.1159/000244030.

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Iriti, Marcello, and Franco Faoro. "Bioactivity of Grape Chemicals for Human Health." Natural Product Communications 4, no. 5 (May 2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400502.

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Grapevine ( Vitis vinifera) products, grape and grape juice, represent a valuable source of bioactive phytochemicals, synthesized by three secondary metabolic pathways (phenylpropanoid, isoprenoid and alkaloid biosynthetic routes) and stored in different plant tissues. In the last decades, compelling evidence suggested that regular consumption of these products may contribute to reducing the incidence of chronic illnesses, such as cancer, cardiovascular diseases, ischemic stroke, neurodegenerative disorders and aging, in a context of the Mediterranean dietary tradition. The health benefits arising from grape product intake can be ascribed to the potpourri of biologically active chemicals occurring in grapes. Among them, the recently discovered presence of melatonin adds a new element to the already complex grape chemistry. Melatonin, and its possible synergistic action with the great variety of polyphenols, contributes to further explaining the observed health benefits associated with regular grape product consumption.
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Elliott, Steve, Tony Lorenzini, David Chang, Jack Barzilay, and Evelyne Delorme. "Mapping of the Active Site of Recombinant Human Erythropoietin." Blood 89, no. 2 (January 15, 1997): 493–502. http://dx.doi.org/10.1182/blood.v89.2.493.

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Abstract Recombinant human erythropoietin (rHuEPO) variants have been constructed to identify amino acid residues important for biological activity. Immunoassays were used to determine the effect of each mutation on rHuEPO folding. With this strategy, we could distinguish between mutations that affected bioactivity directly and those that affected bioactivity because the mutation altered rHuEPO conformation. Four regions were found to be important for bioactivity: amino acids 11 to 15, 44 to 51, 100 to 108, and 147 to 151. EPO variants could be divided into two groups according to the differential effects on EPO receptor binding activity and in vitro biologic activity. This suggests that rHuEPO has two separate receptor binding sites. Mutations in basic residues reduced the biologic activity, whereas mutations in acidic residues did not. This suggests that electrostatic interactions between rHuEPO and the human EPO receptor may involve positive charges on rHuEPO.
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Li, Yun Cang, Jian Yu Xiong, C. S. Wong, Peter D. Hodgson, and Cui E. Wen. "Bioactivating the Surfaces of Titanium by Sol-Gel Process." Materials Science Forum 614 (March 2009): 67–71. http://dx.doi.org/10.4028/www.scientific.net/msf.614.67.

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In the present study, titanium (Ti) samples were surface-modified by titania (TiO2), silica (SiO2) and hydroxyapatite (HA) coatings using a sol-gel process. The bioactivity of the film-coated Ti samples was investigated by cell attachment and morphology study using human osteoblast-like SaOS-2 cells. Results of the cell attachment indicated that the densities of cell attachment on the surfaces of Ti samples were significantly increased by film coatings; the density of cell attachment on HA film-coated surface was higher than those on TiO2 and SiO2 film-coated surfaces. Cell morphology study showed that the cells attached, spread and grew well on the three kinds of film-coated surfaces. It can be concluded that the three kinds of film coatings can bioactivate the surfaces of Ti samples effectively. Overall, Ti sample with HA film-coated surface exhibited the best bioactivity.
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Dissertations / Theses on the topic "Human bioactivity"

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Ferruzzi, Mario G. "Digestive stability, human intestinal cell uptake, and bioactivity of dietary chlorophyll derivatives /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394475978215.

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Yateman, Martin Edward. "Regulation of human fibroblast insulin-like growth factor (IGF)-binding proteins by IGF-1 and cytokines, mechanisms of action and effects upon IGF bioactivity." Thesis, Queen Mary, University of London, 1995. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1742.

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The insulin-like growth factors, IGF-I and IGF-II, are ubiquitous polypeptide molecules that have mitogenic and metabolic actions in a wide variety of cell types, and consequently play a major role in mammalian growth and development. Unlike many other peptide hormones, IGF levels and their bioactivity are highly dependent upon the secretion of a family of six specific binding proteins, named IGFBPs. In this thesis, we have developed a normal human fibroblast in vitro cell culture model to investigate both factors that affect IGFBP secretion, the mechanisms behind such regulation, and also the effect of IGFBP modulation upon subsequent IGF-I mitogenic activity. Firstly, we have examined the possible role that the recently discovered IGFBP proteases may have in determining the effect of IGF-I on IGFBP-3 abundance in fibroblast conditioned media. We show that IGF-I increased IGFBP-3 when assessed by ligand blotting, but did not increase immunoreactive IGFBP-3, a discrepancy that could be explained by further data showing an inhibitory effect of IGF-I on the activity of the fibroblast IGFBP-3 protease. Thus, IGF-I protection of IGFBP-3 from enzymatic degradation may help explain the post-transcriptional, non-receptor mediated 'stimulation' of IGFBP-3 by IGF-I in these cells. We also show for the first time the ability of a number of cytokines to regulate IGFBP secretion, perhaps indicating a novel pathway of communication between these immune cell molecules and the IGFs. The inflammatory cytokine interleukin 113(] L-16) inhibited Hs68 fibroblast IGFBP-3 secretion by down-regulating its gene expression, whilst tumour necrosis factor oc (TNF(x) had a similar inhibitory effect on IGFBP-3 and IGFBP-4 but acted via a post-transcriptional mechanism. The exact nature of the TNF(x effect remains to be determined as no evidence was found to suggest TNF(x increased IGFBP protease activity, or that TNF(x removed IGFBPs from the conditioned media by increasing the proportion immobilised on the cell surface. The inhibition of IGFBP secretion by TNF(x was observed to have marked effects upon the mitogenic activity of IGF-I in these cells, with a five-fold increase in sensitivity to the growth factor seen in a novel cytochemical bioassay. 1 Inhibition of fibroblast IGFBP secretion appeared to be restricted to certain cytokines as IL-6 had no effect, whilst high doses of interferon gamma abolished the TNF(X effect. Conversely, transforming growth factor 6 (TGFB) directly stimulated fibroblast IGFBP-3 secretion, via an increase in gene expression, and subsequently resulted in the reduction in the mitogenic activity of IGF-I. These data indicate that a variety of mechanisms can be employed by a number of factors to elicit changes in fibroblast IGFBP secretion, and that these changes may have direct consequencesin determining IGF-I bioactivity. Such is the importance given to the IGFs in maintaining normal somatic growth, changes in IGFBP secretion may contribute to the altered cellular growth and metabolism seen associated with cytokines in conditions as diverse as chronic infection, rheumatoid arthritis, cancer and the wound healing process.
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De, Araújo Júnior José Vitor. "Chitosan/carrageenan-based polyelectrolyte complexes and their composites with calcium phosphate for bone tissue engineering." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608264.

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Aor, Bruno. "Engineering microchannels for vascularization in bone tissue engineering." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0430/document.

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In vitro, la formation de structures de type tubulaire avec des cellules endothéliales de veine ombilicale humaine (HUVEC) a été étudiée en combinant la fonctionnalisation de la chimie des matériaux et le développement de la géométrie tridimensionnelle. Le polycarbonate (PC) a été utilisé comme modèle pour le développement de l'échafaud. Le film de polysaccharide naturel, basé sur un dépôt alternatif couche par couche (LbL) d’acide hyaluronique (HA) et de chitosane (CHI), a d’abord été appliqué sur une surface PC et caractérisé en termes de croissance d’épaisseur microscopie à balayage lascar (CLSM). Cette première fonctionnalisation se traduit par un revêtement complet de la couche PC. Une biofonctionnalisation supplémentaire avec un peptide adhésif (RGD) et deux peptides angiogénétiques (SVV et QK) a été étudiée, immobilisant ces peptides sur le groupe carboxylique de HA précédemment déposé, en utilisant la chimie bien connue du carbodiimide. La version marquée de chaque peptide a été utilisée pour caractériser l’immobilisation et la pénétration des peptides dans les couches de polyélectrolytes, aboutissant à une greffe réussie avec une pénétration complète dans toute l’épaisseur du LbL. Des tests in vitro ont été effectués à l'aide de cellules HUVEC pour évaluer leur efficacité d'adhésion et leur activité métabolique sur la LbL avec et sans immobilisation de peptides, ce qui a permis d'améliorer l'activité préliminaire lorsque des combinaisons de peptides sont utilisées. Enfin, les micro-canaux PC (μCh) ont été développés et caractérisés pour la première fois, et les autres expériences ont été réalisées sur un micromètre de 25 μm de largeur, fonctionnalisé avec une architecture (HA / CHI) 12,5 (PC-LbL) avec des peptides RGD et QK -RGD + QK) ou avec des peptides RGD et SVV (PC-RGD + SVV). Notre première expérience de tubulogénèse a montré de manière surprenante la formation de structures de type tubulaire déjà après 2h d'incubation en utilisant la combinaison double-peptides, mais uniquement avec PC-RGD + QK. Les tubes étaient également présents après 3 et 4 heures de culture. L'expérience de co-culture avec des péricytes humains dérivés du placenta (hPC-PL) montre comment la stabilisation des tubes a été améliorée après 3 et 4 heures également pour l'échantillon de PC-RGD + SVV. Globalement, notre matériel bio-fonctionnel avec les peptides PC-RGD + QK et PC-RGD + SVV permet la formation d'une structure de type tubulaire à la fois dans une expérience de monoculture et de co-culture
In vitro, tubular-like structures formation with human umbilical vein endothelial cells (HUVECs) was investigated by combining material chemistry functionalization and three-dimensional geometry development. Polycarbonate (PC) was used as a template for the development of the scaffold. Natural polysaccharide’s film based on alternate layer-by-layer (LbL) deposition of hyaluronic acid (HA) and chitosan (CHI), was first applied to PC surface and characterized in terms of thickness growth both, in dry conditions using ellipsometry, and confocal lascar scanning microscopy (CLSM). This first functionalization results in a complete coating of the PC layer. Further biofunctionalization with one adhesive peptide (RGD) and two angiogenetic peptides (SVV and QK) was investigated, immobilizing those peptides on the carboxylic group of HA previously deposited, using the well-known carbodiimide chemistry. The labeled version of each peptide was used to characterize the peptides’ immobilization and penetration into the polyelectrolytes layers, resulting in a successful grafting with complete penetration through the entire thickness of the LbL. In vitro tests were performed using HUVECs to assess their adhesion efficiency and their metabolic activity on the LbL with and without peptide immobilization, resulting in a preliminary improved activity when peptide-combinations is used. Finally, PC micro-channels (μCh) were first developed and characterized, and the rest of the experiments were performed on μCh of 25μm width, functionalized with (HA/CHI)12.5 architecture (PC-LbL) with RGD and QK peptides (PC-RGD+QK) or with RGD and SVV peptides (PC-RGD+SVV). Our first tubulogenesis experiment surprisingly showed the formation of tubular-like structures already after 2h of incubation using the double-peptides combination but only using PC-RGD+QK the tubes were present also after 3 and 4 hours of culture. The co-culture experiment with human pericytes derived from placenta (hPC-PL) demonstrates how the stabilization of the tubes was improved after 3 and 4 hours also for the PC-RGD+SVV sample. Globally our bio-functional material with PC-RGD+QK and PC-RGD+SVV peptides allow the formation of tubular-like structure in both mono and co-culture experiment
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Hamill, Lesley L. "Whole grain components : bioavailability and bioactivity in humans." Thesis, University of Ulster, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554200.

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Epidemiological evidence indicates that increased consumption of whole grain foods is associated with decreased incidence of chronic diseases. The mechanisms underlying these effects are poorly understood but may be due to the antioxidant effects of phenolics or other components. The first postprandial study assessed the effects of consumption of minimally processed wheat bran and aleurone fractions on ferulic acid responses and antioxidant measures in humans. Results showed that both fractions significantly increased urinary total phenolics and plasma and urinary ferulic acid, and that plasma MetSO was significantly reduced after consumption of aleurone. The second postprandial study, which assessed the effects of consumption of aleurone, incorporated into breads, with or without iron addition, showed significant increases in plasma and urinary ferulic acid, and significant decreases in plasma MetSO; the addition of iron did not influence these responses. The third study, which assessed the effects of longer term consumption of aleurone enriched products on antioxidant, inflammatory and other disease risk factors in a parallel, four week intervention study, showed significant decreases in hs CRP and LDL-cholesterol, but other lipids and biomarkers of inflammatory status were unaffected. Furthermore, there were no significant effects on fasting plasma ferulic acid, or antioxidant, anthropometric or blood glucose measures. Overall, the results indicated that wheat bran and aleurone fractions can impact on postprandial ferulic acid levels, and antioxidant measures, and that longer term consumption of wheat aleurone enriched products can ameliorate inflammatory and lipid biomarkers. Future studies should further assess these effects, and extend this work to other components and mechanisms underlying the health benefits of whole grains.
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De, Ferrars Rachel. "The metabolic fate and bioactivity of anthocyanins in humans." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/49475/.

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Anthocyanins, the class of flavonoid responsible for giving a red hue to many berries, have been associated with a decreased risk of cardiovascular disease. However, numerous intervention studies feeding anthocyanin-rich foods report limited (<1%) bioavailability of the parent anthocyanins in vivo. Due to the instability of anthocyanins at neutral pH, it is postulated that degradation products and metabolites of anthocyanins may be responsible for the perceived bioactive effects. The aims of the present thesis were: (1) To model and establish analytical methods for the extraction and quantification of putative anthocyanin metabolites in urine, serum and faecal samples. (2) To identify and explore the pharmacokinetics of anthocyanin metabolites via the analysis of urine, serum and faecal samples from two human interventions, feeding either (a) 500 mg of isotopically (13C5) labelled anthocyanin or (b) 500 mg elderberry anthocyanins for 12 wks. (3) To explore the impact of acute (500 mg) versus chronic (500 mg/day for 12 wks) anthocyanin consumption on their metabolism and (4) To investigate the anti-inflammatory activity of six anthocyanin metabolites at physiologically relevant concentrations (0.01 μM to 10 μM) using human umbilical vein endothelial cells (HUVECs). Following the consumption of 500 mg elderberry anthocyanins, 28 anthocyanin metabolites were identified in urine and 21 in plasma, with the phenolic metabolites within plasma identified at 45 fold higher levels than their parent compounds. Similar results were observed within the 13C-labelled anthocyanin intervention, where 17 13C-labelled compounds were identified in serum and 31 in urine. However, chronic consumption of anthocyanins had no impact on the formation of the metabolites. The cardiovascular bioactivity of anthocyanins may be linked to the antiinflammatory activity of their metabolites. IL-6 and VCAM-1 are cytokines and adhesion molecules integral to the initiation and progression of inflammation. In vitro, anthocyanin metabolites reduced CD40L and TNF-α stimulated expression of the inflammatory markers, sVCAM-1 and IL-6, indicating that the anti-inflammatory effects of anthocyanins are likely attributed to their metabolites. In conclusion, the present thesis provides a new understanding into the metabolism and bioactivity of anthocyanins, which should provide an informative insight into how the consumption of higher intakes of anthocyanins may contribute to optimising human health.
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Taylor, Alistair Michael. "Bioactivity of the insulin-like growth factors in normal and diabetic humans and rats." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266647.

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Williamson, Kelly Scott. "Pharmacology, epidemiology, and bioactivites of tocopherols and their metabolites in human and non-human models for inflammatory disease." Oklahoma City : [s.n.], 2008.

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Ben, Henda Yesmine. "Bioactivités de cryptides marins : quels potentiels pour la santé humaine ?" Thesis, La Rochelle, 2014. http://www.theses.fr/2014LAROS032/document.

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Les ressources marines constituent un réservoir considérable de substances actives, en particulier, de peptides bioactifs appelés cryptides. Les cryptides, qui sont initialement dissimulés au cœur des protéines, sont libérés lors de la digestion ou lors de procédés protéolytiques industriels. Ces cryptides pourraient procurer des bienfaits physiologiques ou assurer une protection contre des pathologies telles que celles du syndrome métabolique. Dans ce contexte, nous nous sommes intéressés à l’action de certains cryptides marins sur des cibles impliquées dans l’hypertension, le diabète et l’obésité. Nous avons pu mettre en évidence que certains cryptides pouvaient cibler in vitro plusieurs facteurs de risques associés au développement des anomalies du syndrome métabolique
Marine products represent an important source of active substances, in particular bioactive peptides called cryptides. Cryptides are hidden within the sequence of a parent protein and are released during digestion or industrial proteolytic processes. These cryptides could provide physiological benefit or protection against diseases such as those of metabolic syndrome. In this context, we investigated the action of some marine cryptides on hypertension, diabetes and obesity. We demonstrated that some cryptides can target in vitro several factors associated with the development of metabolic syndrome
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Faure, Dominique. "Dégradation du facteur natriurétique auriculaire humain in vitro et in vivo : immunoréactivité et bioactivité des fragments de dégradation chez le sujet sain et pathologique." Bordeaux 2, 1996. http://www.theses.fr/1996BOR28420.

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Book chapters on the topic "Human bioactivity"

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Kunz, Clemens, Sabine Kuntz, and Silvia Rudloff. "Bioactivity of Human Milk Oligosaccharides." In Food Oligosaccharides, 1–20. Chichester, UK: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118817360.ch1.

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Kapurniotu, A., and J. W. Taylor. "Structural features of human calcitonin bioactivity: CD and bioactivity studies of cyclic human calcitonin analogues." In Peptides 1994, 625–26. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-1468-4_285.

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Kluge, Stefan, Martin Schubert, Lisa Schmölz, Maria Wallert, Marc Birringer, and Stefan Lorkowski. "Bioactivity of Vitamin E Long-Chain Metabolites." In Vitamin E in Human Health, 61–79. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05315-4_6.

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Wessel, M. D., P. C. Jurs, J. W. Tolan, and S. M. Muskal. "Prediction of Human Intestinal Absorption of Drug Compounds from Molecular Structure." In Molecular Modeling and Prediction of Bioactivity, 249–55. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-4141-7_30.

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Yamashita, Eiji. "Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human." In Advances in Experimental Medicine and Biology, 249–59. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-7360-6_23.

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de Wit, Maryna, and Herman Fouché. "South African Perspective on Opuntia spp.: Cultivation, Human and Livestock Food and Industrial Applications." In Opuntia spp.: Chemistry, Bioactivity and Industrial Applications, 13–47. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-78444-7_2.

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Ligor, Magdalena, Ileana-Andreea Rațiu, Hossam Al-Suod, Agnieszka Owczarczyk-Saczonek, Lesław Lahuta, Ryszard Górecki, and Bogusław Buszewski. "Cyclitols – Determination in Food and Bioactivity in the Human Organism." In Food Bioactive Ingredients, 163–91. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-61879-7_7.

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Policepatel, Shivakumar Singh, Pavankumar Pindi, and Vidyasagar Gunagambhere Manikrao. "In-Vitro Antidermatophytic Bioactivity of Peel Extracts of Red Banana (Musa Acuminate) and Common Banana (Musa Paradisica)." In Assessment of Medicinal Plants for Human Health, 191–201. Series statement: Innovations in plant science for better health : from soil to fork: Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429328541-16.

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Born, Walter, Nigel Loveridge, Charles Nagant de Deuxchaisnes, and Jan A. Fischer. "Inhibition of Parathyroid Hormone Bioactivity in Pseudohypoparathyroidism Type I and by Human PTH (3–84) Produced inE.Coli." In New Actions of Parathyroid Hormone, 387–91. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0567-5_44.

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Karlén, Anders, Susanne Winiwarter, Nicholas Bonham, Hans Lennernäs, and Anders Hallberg. "Correlation of Intestinal Drug Permeability in Humans (In Vivo) with Experimentally and Theoretically Derived Parameters." In Molecular Modeling and Prediction of Bioactivity, 491–92. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-4141-7_132.

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Conference papers on the topic "Human bioactivity"

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Chahal, Bindu, Mun'delanji C. Vestergaard, Tsuyoshi Yoda, Masamune Morita, and Masahiro Takagi. "Structure-dependent membrane interaction and bioactivity of flavonoids with lipid bilayers." In 2012 International Symposium on Micro-NanoMechatronics and Human Science (MHS). IEEE, 2012. http://dx.doi.org/10.1109/mhs.2012.6492463.

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HU, Yan-ying, Yong-hui ZHONG, Jing ZHEN, Hui-tu ZHANG, Shi-ru JIA, Fu-ping LU, Yu-jie DAI, and Xiu-li ZHANG. "Extracellular Expression and Catalytic Bioactivity of Optimized Human Aromatase (CYP19) in Pichia Pastoris." In 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017). Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/bbe-17.2017.3.

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Chen, Y. K., H. Ji, and X. B. Zheng. "Apatite Formation on Vacuum Plasma Sprayed Titanium Coating after Chemical Modification." In ITSC2007, edited by B. R. Marple, M. M. Hyland, Y. C. Lau, C. J. Li, R. S. Lima, and G. Montavon. ASM International, 2007. http://dx.doi.org/10.31399/asm.cp.itsc2007p0381.

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Abstract Formation of bonelike apatite is an essential prerequisite for implants to make direct bond to living bone. The apatite formation can be assessed in vitro using a simulated body fluid (SBF) that has almost equal compositions of inorganic ions to human blood plasma. In this study, Ti coatings were prepared by vacuum plasma spraying, and then they were treated by NaOH aqueous solution, immersed in distilled water, heated at 600 °C in a furnace. Microstructure and bioactivity of the surface modified Ti coatings were examined by SEM observation and SBF test respectively. The results obtained revealed that a net-like structure comprising of many micropores was present on the surfaces of the treated Ti coatings. After immersed in SBF, apatite layer was formed on their surfaces, suggesting that the surface modification coatings have good bioactivity.
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Liao, Chao-Yaug, Po-Lun Wu, and Chao-Yu Lee. "Customized PEEK Implants With Microporous and Surface Modification Using 3D Printing." In ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-97117.

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Abstract Polyetheretherketone (PEEK) is a high-performance, semi-crystalline thermal polymer with medical advantages such as biocompatibility and radiolucency. PEEK has an elastic modulus comparable to that of human cortical bone, so it can effectively reduce the stress shielding effect caused by the mismatch between the mechanical properties of an implant and human bone tissue. However, PEEK is biologically inert, and its use typically relies on a variety of surface modification methods, such as surface coatings of bio-ceramic materials, enhancing the surface bioactivity, and osseointegration. Compared to thermal spray or plasma spray technologies, the cold spray is carried out at relatively low temperatures, retaining the original properties of the material. This research establishes an open-source three-dimensional printer compatible with PEEK and also develops a powder-spray module based on the cold spray technology that can coat the surfaces of PEEK printings with hydroxyapatite (HA) to improve its bioactivity. This paper discusses the best parameter selection for PEEK printing, a thermal history analysis of the printing process, and the adhesion of HA powder coated on PEEK specimens with different porosities. Finally, the PEEK implant is printed to measure its performance under a vertical load.
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Lechman, Eric R., Bernhard Gentner, Peter van Galen, Kolja Eppert, Katsuto Takenaka, Mark Minden, Luigi Naldini, and John E. Dick. "Abstract 1013: Enriched miR-126 bioactivity marks the primitive compartment in human AML and regulates leukemia stem cell numbers." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1013.

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Fang, Hsu-Wei, and Yu-Chih Su. "Effects of Biological Lubrication on the Morphology of UHMWPE Wear Particles Generated With Surface Textures." In World Tribology Congress III. ASMEDC, 2005. http://dx.doi.org/10.1115/wtc2005-63501.

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Osteolysis induced by ultra-high molecular weight polyethylene (UHMWPE) wear particles has emerged as a critical failure mechanism of artificial joints. Many researchers have performed cell culture studies or animal tests to investigate the UHMWPE particles induced immunological responses. However, the effect of size and shape remains elusive. This is partly because of the difficulty in obtaining UHMWPE wear particles with specific sizes and shapes for bioactivity tests. Previously, we have shown the feasibility of producing narrowly distributed UHMWPE particle sizes and shapes by rubbing UHMWPE pins against textured surfaces [1]. The correlations between the surface texture dimensions and the size and shape of wear particles generated in water have been obtained [2]. In addition, this novel technique of UHMWPE particle generation enables the investigation of the effects of UHMWPE particle size and shape on bioactivity. It is concluded that the elongated particles and the particles which can be engulfed by macrophage cells induced stronger immunological responses [3]. Thus, it is possible to enhance the life of total joint replacements by reducing the production of the most toxic particle populations in terms of size and shape. Our idea is to apply surface textures on the articulating surface of joint implant in order to control the size and shape of UHMWPE wear particles. While maintaining a low wear rate of UHMWPE parts, further reduction of the most “toxic” particles released into human body shall prevent particle-induced osteolysis.
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Lopes Filho, Wilson Roberto, Yago F. Lopes, Lilian T. F. de M. Camargo, and Ademir J. Camargo. "Dinâmica Molecular Ab Initio da Complexarão de Íons zinco com a vitamina C em Fase Gasosa." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol2020166.

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Zinc and vitamin C are essential micronutrients for the conservation of the human body, being essential for the maintenance of the immune system, reducing the risk, severity and duration of infectious diseases. They are taken together as a food supplement, resulting in the improvement of pneumonia and malaria infections. Vitamin C and zinc are also associated with measures of obesity and adiposity. Studies report that vitamin C complexed in zinc promotes adipogenesis and stimulates the generation of insulin-responsive adipocytes. Therefore, since vitamin C together with zinc are fundamental for the body, and that vitamin C complexed with zinc can promote adipogenesis and stimulate the generation of adipocytes responsive to insulin, the study of the interaction between these micronutrients will broaden the understanding of its bioactivity, which may be important in the study of a new use of vitamin C and zinc combined. Thus, it is intended to study the complexation of Vitamin C with the zinc ion using simulations of Molecular Dynamics ab initio. Through the results of the dynamics, it is found that zinc interacted significantly with 3 atoms of vitamin C, thus identifying the formation of a tridentate complex, since the average distances between the metal and these atoms were between 2.176 and 2.261 Å. A decrease in the free Helmholtz energy is perceived as the zinc approaches these atoms, up to a distance of high stability, which corresponds to the average distance of these interactions. It is also evident that the complexation energy is -220,64 Kcal/mol indicating that the complexation is energetically favorable and that the complex formed is stable. Therefore, the results obtained broadened the knowledge about the complexation of zinc ions with vitamin C, which will be of great importance for the understanding of its bioactivity and in the planning of new drugs.
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Suzuki, Takuji, Takuro Sakagami, J. C. van der Loo, Brenna Carey, Claudia Chalk, and Bruce Trapnell. "A Novel Cell Line (mAM-hGM-R) For Measuring The Bioactivity Of GM-CSF And Neutralizing Capacity Of GM-CSF Autoantibodies In Human Serum." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2983.

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Xiao, K., J. A. Dyson, K. W. Dalgarno, P. Genever, D. J. Wood, R. D. Goodridge, and C. Ohtsuki. "Manufacture and Characterisation of Bioceramic Tissue Engineering Scaffolds Produced by Selective Laser Sintering." In ASME 2007 International Manufacturing Science and Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/msec2007-31031.

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Currently there is no adequate bone replacement available that combines a long implant life with complete integration and appropriate mechanical properties. This paper reports on the use of human mesenchymal stem cells (MSCs) to populate porous bioceramic scaffolds produced by selective laser sintering (SLS) to create bespoke bioactive bone replacement structures. Apatite-wollastonite glass ceramic was chosen for use in this study because of its combination of excellent mechanical and biological properties, and has been processed using an indirect SLS approach. Process maps have been developed to identify process conditions for the SLS stage of manufacture and an optimised furnace cycle for the material has been developed to ensure that the required material phases for bioactivity are present in the manufactured scaffold. Results from tissue culture with the MSC’s on the scaffolds (using confocal and scanning electron microscopy) show that MSCs adhere, spread and retain viability on the surface, and penetrate into the pores of apatite wollastonite (A-W) glass ceramic scaffolds over a 21 day culture period. The MSC’s also show strong indications of osteogenesis, indicating that the MSC’s are differentiating to osteoblasts. These results indicate good biocompatibility and osteo supportive capacity of SLS generated A-W scaffolds and excellent potential in bone replacement applications.
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McClure, Michael J., Scott A. Sell, David G. Simpson, Beat H. Walpoth, and Gary L. Bowlin. "Optimizing a Three Layered Electrospun Matrix to Mimic Native Arterial Architecture: Cellular and Mechanical Analysis." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53689.

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The architecture of the vascular wall is highly intricate and requires unique biomechanical properties in order to function properly. Native artery is composed of a mix of collagen, elastin, endothelial cells (ECs), smooth muscle cells (SMC), fibroblasts, and proteoglycans arranged into three distinct layers: the intima, media, and adventitia. Throughout artery, collagen and elastin play an important role, providing a mechanical backbone, preventing vessel rupture, and promoting recovery while undergoing pulsatile deformations [1]. The low-strain mechanical response of artery to blood flow is dominated by the elastic behavior of elastin which prevents pulsatile energy from being dissipated as heat [2]. Previous work has shown the ability to fabricate multi-layered electrospun scaffolds composed of polycaprolactone (PCL), elastin (ELAS), and collagen (COL), and their associated mechanical advantages. PCL was chosen, in this case, to provide mechanical integrity and elasticity, while elastin and collagen would provide further elasticity and bioactivity [3,4]. However, when the grafts were implanted in the descending aorta of a rat, cellular results were not as desirable as predicted. Therefore, further graft optimization was required. The hypothesis of this study was that blended polymers and biopolymers would be conducive for cellular attachment through specific integrin binding sites. To test this hypothesis, human umbilical artery smooth muscle cells (hUASMC) were seeded on electrospun PCL, COL, and ELAS blends for evaluation in a cell adhesion inhibition experiment.
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Reports on the topic "Human bioactivity"

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Cytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7598174.bard.

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Control of agro-associated pathogens is becoming increasingly difficult due to increased resistance and mounting restrictions on chemical pesticides and antibiotics. Likewise, in veterinary and human environments, there is increasing resistance of pathogens to currently available antibiotics requiring discovery of novel antibiotic compounds. These drawbacks necessitate discovery and application of microorganisms that can be used as biocontrol agents (BCAs) and the isolation of novel biologically-active compounds. This highly-synergistic one year project implemented an innovative pipeline aimed at detecting BCAs and associated biologically-active compounds, which included: (A) isolation of multidrug-resistant desert soil bacteria and root-associated bacteria from medicinal plants; (B) invitro screening of bacterial isolates against known plant, animal and human pathogens; (C) nextgeneration sequencing of isolates that displayed antagonistic activity against at least one of the model pathogens and (D) in-planta screening of promising BCAs in a model bean-Sclerotiumrolfsii system. The BCA genome data were examined for presence of: i) secondary metabolite encoding genes potentially linked to the anti-pathogenic activity of the isolates; and ii) rhizosphere competence-associated genes, associated with the capacity of microorganisms to successfully inhabit plant roots, and a prerequisite for the success of a soil amended BCA. Altogether, 56 phylogenetically-diverse isolates with bioactivity against bacterial, oomycete and fungal plant pathogens were identified. These strains were sent to Auburn University where bioassays against a panel of animal and human pathogens (including multi-drug resistant pathogenic strains such as A. baumannii 3806) were conducted. Nineteen isolates that showed substantial antagonistic activity against at least one of the screened pathogens were sequenced, assembled and subjected to bioinformatics analyses aimed at identifying secondary metabolite-encoding and rhizosphere competence-associated genes. The genome size of the bacteria ranged from 3.77 to 9.85 Mbp. All of the genomes were characterized by a plethora of secondary metabolite encoding genes including non-ribosomal peptide synthase, polyketidesynthases, lantipeptides, bacteriocins, terpenes and siderophores. While some of these genes were highly similar to documented genes, many were unique and therefore may encode for novel antagonistic compounds. Comparative genomic analysis of root-associated isolates with similar strains not isolated from root environments revealed genes encoding for several rhizospherecompetence- associated traits including urea utilization, chitin degradation, plant cell polymerdegradation, biofilm formation, mechanisms for iron, phosphorus and sulfur acquisition and antibiotic resistance. Our labs are currently writing a continuation of this feasibility study that proposes a unique pipeline for the detection of BCAs and biopesticides that can be used against phytopathogens. It will combine i) metabolomic screening of strains from our collection that contain unique secondary metabolite-encoding genes, in order to isolate novel antimicrobial compounds; ii) model plant-based experiments to assess the antagonistic capacities of selected BCAs toward selected phytopathogens; and iii) an innovative next-generation-sequencing based method to monitor the relative abundance and distribution of selected BCAs in field experiments in order to assess their persistence in natural agro-environments. We believe that this integrated approach will enable development of novel strains and compounds that can be used in large-scale operations.
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