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Dissertations / Theses on the topic 'Human abdominal sepsis][Sepsis'

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1

Vasconcelos, P. R. L. de. "Hepatic metabolism during sepsis." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233530.

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2

Lattuada, Marco. "Effect of Ventilatory Support on Abdominal Fluid Balance in a Sepsis Model." Doctoral thesis, Uppsala universitet, Klinisk fysiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207218.

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In patients affected by acute respiratory failure or acute respiratory distress syndrome (ARDS) the leading cause of death is failure of different vital organs other than the lungs, so called multiple organ dysfunction syndrome (MODS). The abdominal organs have a crucial role in the pathogenesis of this syndrome. There is a lack of knowledge regarding the mechanisms by which mechanical ventilation can affect the abdominal compartment. One hypothesis is that mechanical ventilation can interfere with abdominal fluid balance causing edema and inflammation. We addressed the question whether differ
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3

Bleszynski, Michael Sean. "Impact of open abdomen and Vacuum Assisted Closure Device in surgical abdominal sepsis." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61001.

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Introduction: Surgical abdominal sepsis has traditionally been managed with by a single staged procedure, otherwise known as primary abdominal closure (PAC). An on demand laparotomy may be performed for post-operative clinical deterioration. Open abdomen and a planned re-laparotomy with vacuum assisted closure (VAC) is an alternate method to single staged procedure. Inflammatory cytokines can potentially help stratify severity of sepsis and guide surgical management. The objective of the study was to identify if inflammatory cytokines could differentiate between PAC and VAC. Secondary objectiv
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4

Perry, Sara Elizabeth. "The phenotypic characterization of the monocyte in human sepsis." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268902.

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5

Sartelli, M., F. M. Abu-Zidan, L. Ansaloni, et al. "The role of the open abdomen procedure in managing severe abdominal sepsis: WSES position paper." BioMed Central, 2015. http://hdl.handle.net/10150/610338.

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The open abdomen (OA) procedure is a significant surgical advance, as part of damage control techniques in severe abdominal trauma. Its application can be adapted to the advantage of patients with severe abdominal sepsis, however its precise role in these patients is still not clear. In severe abdominal sepsis the OA may allow early identification and draining of any residual infection, control any persistent source of infection, and remove more effectively infected or cytokine-loaded peritoneal fluid, preventing abdominal compartment syndrome and deferring definitive intervention and anastomo
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6

Januszkiewicz, Anna. "In vivo protein synthesis determinations in human immune cells /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-219-5/.

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7

Cajander, Sara. "Dynamics of Human Leukocyte Antigen-D Related expression in bacteremic sepsis." Doctoral thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56125.

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Monocytic human leukocyte antigen-D related (mHLA-DR) expression determined by flow cytometry has been suggested as a biomarker of sepsisinduced immunosuppression. In order to facilitate use of HLA-DR in clinical practice, a quantitative real-time PCR technique measuring HLA-DR at the transcription level was developed and evalutated. Levels of HLA-DR mRNA correlated to mHLADR expression and were robustly measured, with high reproducibility, during the course of infection. Dynamics of mHLA-DR expression was studied during the first weeks of bloodstream infection (BSI) and was found to be depend
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8

González, Lisorge Ada. "Estudio sobre la sepsis grave de origen abdominal. Utilidad de la procalcitonina y otros marcadores pronósiticos." Doctoral thesis, Universidad de Murcia, 2013. http://hdl.handle.net/10803/128673.

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INTRODUCCIÓN: La sepsis es una de las principales causas de morbimortalidad en las unidades de cuidados intensivos (UCIs). La sepsis grave de origen abdominal es uno de los cuadros más frecuentes en las UCIs Posquirúrgicas. Su mortalidad es elevada y oscila entre 40% y el 70% según las series. Sin embargo, es un cuadro que suele tener poco protagonismo en la literatura científica. Los biomarcadores son elementos fundamentales para el diagnóstico, seguimiento y pronóstico de la sepsis. Uno de los biomarcadores más estudiados en las últimas décadas ha sido la procalcitonina. Muchos autores consi
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9

Smith, Laura Ann. "Effects of Bacterial Products on Human Blood Leukocytes." University of Toledo Health Science Campus / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=mco1164046331.

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10

Lima, Erica Silva. "Efeito da suplementação dietética com L-glutamina na sepse abdominal induzida em rato." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=5869.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Após o estímulo deflagrador de um trauma ou infecção, a liberação de citocinas na circulação sanguínea desempenha um importante papel efetor e também modulador da resposta imune sistêmica. Essas citocinas podem ser pró-inflamatórias, que estimulam a liberação de diversos tipos celulares e de outras citocinas, como fator de necrose tumoral-alfa (TNF-&#945;), interleucina 1 (IL-1), IL-2, IL-6, IL-8, IL-12 e interferon-gama (INF-&#61543;); ou citocinas com efeitos antiinflamatórios, que inibem o processo inflamatório, em parte pela
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11

Al-Bahrani, Ahmed Z. "An Investigation of Intra-Abdominal Pressure and the Potential Impact of Intra-Abdominal Hypertension on Gut Barrier and Other Organ Functions in Patients With Severe Acute Pancreatitis and in Patients with Abdominal Sepsis." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501974.

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12

Soop, Anne. "Experimental studies on endotoxin infusion in human : evaluation of pharmacological immunomodulation by adenosine and nicotinamide /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-716-9/.

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13

Vesali, Rokhsareh Farrah. "Amino acid and protein turnover in human skeletal muscle /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-285-3/.

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14

O'Leary, Michael James. "Tissue protein catabolism in sepsis : mechanisms, and modulation by nutrition, glutamine and recombinant human growth hormone." Thesis, Queen Mary, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415158.

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15

Youssef, Nermeen. "Assessment of manual and robotic miRNAs extraction methods with optimization of the two-tailed RT-qPCR technology for miRNAs detection as biomarkers from human plasma for early sepsis diagnosis : Future diagnostics of sepsis." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20233.

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Sepsis is a life-threatening syndrome that occurs due to dysregulated body response to pathogenic infections. More than 30 million cases are recorded annually worldwide, with a high mortality rate of up to 40% of the recorded cases. Early diagnosis of sepsis will help clinicians to start proper therapy as early as possible and save lives. Circulating miRNAs in biofluids were found previously as potential biomarkers that can be used in a multi-marker panel to develop a rapid, friendly user diagnostic kit for the early sepsis diagnosis. This study assessed miRNAs from healthy donors’ human plasm
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16

Krüger, Anne [Verfasser], and Carsten Jürgen [Akademischer Betreuer] Kirschning. "Towards understanding bacterial induced sepsis : RNA recognition by murine TLR13 and human TLR8 / Anne Krüger. Betreuer: Carsten Jürgen Kirschning." Duisburg, 2016. http://d-nb.info/1109745583/34.

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17

Merino, Chávez Oscar Miguel. "Estudio comparativo de la evolución de la sepsis abdominal con relaparotomía a demanda y relaparatomía planeada. Hospital Alberto Sabogal Sologuren – Callao - Perú, enero 2004 a diciembre 2005." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2006. https://hdl.handle.net/20.500.12672/15869.

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La sepsis abdominal es una de las patologías con alta mortalidad y costos elevados. A pesar de los avances en antibioticoterapia y manejo intensivo se registran valores de hasta un 70 % de mortalidad, estancias hospitalarias prolongadas y gran número de complicaciones. El estudio tiene como finalidad la comparación entre la evolución de los pacientes con sepsis de origen abdominal sometidos a relaparotomías a demanda y la de aquellos tratados con relaparotomías planeadas. Se contó con una muestra total de 137 pacientes con sepsis abdominal, de los cuales 63 fueron sometidos a Relaparotomía Pla
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18

Mommert, Marine. "Modulation de l'expression des rétrovirus endogènes humains dans des contextes d'inflammation et d'immunosuppression." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEN044.

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Le sepsis est défini par l’apparition de dysfonctions d’organes, multiples et mortelles, causées par une réponse de l’hôte dérégulée suite à une infection. L’hétérogénéité de la maladie représente un défi clinique majeur au regard de la prise en charge thérapeutique, et à ce jour les marqueurs proposés ne suffisent pas à stratifier les patients. Les rétrovirus endogènes humains (HERV) pourraient être des marqueurs pertinents,compte tenu des propriétés immunosuppressives de leurs enveloppes et de leur expression dans des maladies inflammatoires et auto-immunes. Cette thèse a pour objectif de sa
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19

Ara?jo, Filho Irami. "Influ?ncia da laparoscopia e da laparotomia na gasometria, leucometria diferencial e citocinas em modelo de sepse abdominal em ratos." Universidade Federal do Rio Grande do Norte, 2005. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13419.

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Made available in DSpace on 2014-12-17T14:14:03Z (GMT). No. of bitstreams: 1 IramiAF.pdf: 222778 bytes, checksum: 19ba0c4bd484b69016b906c3ab34fc7f (MD5) Previous issue date: 2005-10-27<br>Laparoscopic surgery is associated with reduced surgical trauma, and less acute phase response, as compared with open surgery. Cytokines are important regulators of the biological response to surgical and anesthetic stress. The aim of this study was to determine if CO2 pneumoperitoneum would change cytokine expression, gas parameters and leukocyte count in septic rats. Methods: Wistar rats were randomly ass
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20

Von, Ehr Michelle. "Optimization of the Two-Tailed RT qPCR method with synthetic miR-16 and miR-210 in human plasma for future diagnostics of sepsis." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18844.

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Every year, around 6 million people lose the fight against sepsis. Sepsis is a dysregulated response from the host to an infection, leading to life-threatening organ dysfunction. The gold-standard diagnostics of sepsis to date is blood culturing and the results take up to three days to be validated Therefore, it is important to focus on biomarkers like MicroRNA [miRNA] to develop faster diagnostics tools as they have previously shown to be potential minimally-invasive biomarkers for many diseases of different origin. RT-qPCR is known to amplify DNA, while a new primer, called the two-tailed pr
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21

Souza, Yglesio Luciano Moyses Silva de. "Avaliação dos efeitos da ozonioterapia no tratamento da infecção intra-abdominal em ratos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-05032010-164441/.

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INTRODUÇÃO: O ozônio (O3) é encontrado na natureza e também pode ser produzido no corpo humano através da ativação de anticorpos. Seus efeitos anti-bactericidas são descritos na literatura, mas esses dados são controversos quanto a um potencial efeito benéfico da ozonioterapia no tratamento de certos tipos de infecção. OBJETIVO: Avaliar os efeitos da aplicação intraperitoneal (i.p.) de uma mistura gasosa de ozônio em um modelo de ligadura e punção de ceco (LPC) em ratos, através da dosagem de interleucinas (IL)-6, IL-10 e da quimiocina CINC-1 (cytokine-induced neutrophil chemoattractant), da l
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22

Stephens, Alick Christopher. "Studies on human monocyte tissue factor expression and inhibition following endotoxin exposure : plasma measurement of tissue factor and tissue factor pathway inhibitor in sepsis." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393656.

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23

Oliveira, Luciana Mello de. "Frequência reduzida de genes KIR ativadores em pacientes com sepse." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/149582.

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Base teórica: A sepse é uma síndrome heterogênea, definida como disfunção orgânica que ameaça à vida, causada por uma resposta desregulada do hospedeiro à infecção. É um problema de saúde mundial, graças à sua alta prevalência, morbimortalidade associada, além de custos para seu tratamento. As células Natural Killer (NK) fazem parte do sistema imune inato reconhecendo moléculas de HLA de classe I em células alvo, através de seus receptores de membrana killer cell immunoglobulin-like receptors (KIR). A intensidade da resposta à infecção pode variar entre indivíduos, logo pode-se considerar que
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24

Costa, Luciane Pires da. "Consumo de óleo de peixe na resposta inflamatória em ratos submetidos a esplenectomia total isolada ou combinada com autoimplante esplênico e à indução de sepse abdominal." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4858.

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Em órgãos potencialmente importantes na resposta imune, como o baço, alternativas como o autoimplante de segmentos esplênicos, quando a esplenectomia total torna-se necessária, e a utilização de nutrientes com funcionalidade imunomoduladora vêm sendo estudadas, objetivando minimizar o efeito pró-inflamatório persistente da sepse abdominal. O objetivo deste trabalho foi avaliar o efeito do consumo de óleo de peixe na modulação da resposta inflamatória em animais submetidos a esplenectomia total isolada ou combinada com autoimplante esplênico e à indução de sepse abdominal, verificando a possíve
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25

Berthet, Julien. "Rôle fonctionnel du Toll-Like Receptor 4 exprimé par les plaquettes sanguines en tant que cellules inflammatoires de l'immunité." Phd thesis, Université Jean Monnet - Saint-Etienne, 2010. http://tel.archives-ouvertes.fr/tel-00673243.

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Les plaquettes jouent un rôle majeur dans l'hémostase primaire ainsi que dans l'inflammation. Elles contiennent et sécrètent une grande variété de facteurs solubles et parmi les nombreux récepteurs qu'elles expriment à leur surface, les plaquettes expriment les " Toll-Like Receptor " (TLR), récepteurs clés de l'interaction entre l'immunité innée et adaptative. En réponse à un stimulus infectieux, comme le lipopolysaccharide (LPS) des bactéries Gram-négative, ligand naturel du TLR4, ou des peptides issus d'une partie de la protéine d'enveloppe du VIH (gp41), les plaquettes vont s'activer de man
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26

Bürfent, Benedikt [Verfasser]. "The immunomodulatory capacity of helminths on inflammation: Impact of eosinophils on E. coli-induced sepsis and genome-wide transcriptome profiling of human monocytes stimulated with helminth extract and LPS implicate immune functions and diseases / Benedikt Bürfent." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1149154284/34.

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27

Manzoli, Talita Freitas. "Dosagem de HLA-DR (Human Leukocyte antigen DR) de mononucleares para avaliação de imunoparalisia em pacientes sépticos na Unidade de Terapia Intensiva Pediátrica (UTIP) de um Hospital Terciário." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-09082017-114631/.

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O presente estudo avaliou a ocorrência de imunoparalisia e sua associação com pior prognóstico em pacientes pediátricos internados em uma UTI de hospital terciário. Para determinar a presença de imunoparalisia procedeu-se a dosagem da expressão de mHLA-DR usando o QuantiBRITE TM Anti HLA-DR/ Anti- Monocyte, um novo reagente que padroniza os valores da citometria de fluxo para o mHLA-DR. Determinamos a expressão de mHLA-DR em 30 pacientes com sepse grave ou choque sépticos admitidos na UTI Pediátrica no período do estudo, mHLA-DR foi quantificado por duas vezes: entre os dias 3 a 5 (mHLA-DR1) e
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28

Monteiro, Norberto de K?ssio Vieira. "Avalia??o das atividades anti-inflamat?ria, anticoagulante e antiproliferativa do inibidor de quimotripsina das sementes de erythrina velutina (EvCI)." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12579.

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Made available in DSpace on 2014-12-17T14:03:37Z (GMT). No. of bitstreams: 1 NorbertoKVM_DISSERT.pdf: 2522986 bytes, checksum: 6298d49730e0d9c9d5418ad46a9b33f5 (MD5) Previous issue date: 2011-02-22<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Studies indicate that several components were isolated from medicinal plants, which have antibacterial, antifungal, antitumor and anti-inflammatory properties. Sepsis is characterized by a systemic inflammation which leads to the production of inflammatory mediators exacerbated by excessive activation of inflammatory cells and disse
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29

Boontham, Pisake. "Significant and selective modulation of function and survival in vitro of human dendritic cells (DCs) and T cell subsets by N-(3-oxododecanoyl)-L-homoserine lactones : a paradigm for understanding dysfunction of host defences in vivo in sepsis in man." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422764.

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30

Préau, Sébastien. "Implication du cytosquelette dans les dysfonctions myocardiques : exemple de la cardiomyopathie septique." Phd thesis, Université du Droit et de la Santé - Lille II, 2013. http://tel.archives-ouvertes.fr/tel-01018473.

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Le cytosquelette se compose de microfilaments (polymères d'actine), de microtubules (polymères de tubuline) et de filaments intermédiaires (polymères de desmine, de lamines ...). Le sepsis défini par une infection associée à une réaction inflammatoire systémique est responsable de dysfonctions myocardiques de mauvais pronostique. Cette cardiomyopathie apparait dans les premières heures du sepsis et guérit en moins de deux semaines chez les survivants. Même si certaines études démontrent l'implication d'éléments du cytosquelette dans la cardiomyopathie septique, les rôles des microfilaments et
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31

Grimaldi, David. "Mécanismes cellulaires et moléculaires de l'immunodépression post-infectieuse." Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00924659.

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Les infections graves entraînent une dysrégulation de la réaction inflammatoire associée à une immunodépression complexe associée à la survenue d'infections nosocomiales. Les mécanismes cellulaires et moléculaires qui régulent ces phénomènes demeurent largement incompris. A l'interface entre système immunitaire inné et adaptatif, les cellules dendritiques et les lymphocytes innés pourraient être impliqués dans l'immunodépression post-infectieuse. Par ailleurs, les récepteurs de type Toll (TLR) déterminent l'amplitude de la réponse inflammatoire initiale, mais leur contribution dans le développ
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32

Navarro, Xavier. "Analysis of cerebral and respiratory activity in neonatal intensive care units for the assessment of maturation and infection in the early premature infant." Phd thesis, Université Rennes 1, 2013. http://tel.archives-ouvertes.fr/tel-00979727.

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This Ph.D. dissertation processes and analyzes signals from the neonatal intensive care units (NICUs) for the study of maturity, systemic infection (sepsis) and the influence of immunization in the premature newborn. A special attention is payed to the electroencephalography and the breathing signal. The former is often contaminated by several sources of noise, thus methods based on the signals decomposition and optimal noise cancellation, adapted to the characteristics of the immature EEG, were proposed and evaluated objectively on real and simulated signals. By means of the EEG and delta bur
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33

Yang, Q., M. Zhang, Dean J. Harrington, G. W. Black та I. C. Sutcliffe. "A proteomic investigation of Streptococcus agalactiae reveals that human serum induces the C protein β antigen and arginine deiminase". 2011. http://hdl.handle.net/10454/11568.

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No<br>Streptococcus agalactiae is a major neonatal pathogen. Disease progression is characterised by bacterial adaptation from commensal maternal vaginal colonisation to environments associated with neonatal disease, including exposure to blood. To explore this adaptation in vitro, we have used proteomics to identify proteins differentially expressed following growth on Todd Hewitt agar in the presence or absence of 10% v/v human serum. Twelve differentially expressed proteins were identified. Notably, the C protein β antigen and arginine deiminase proteins were upregulated following growth in
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