Academic literature on the topic 'HSC criteria'
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Journal articles on the topic "HSC criteria"
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Hyatt, Sarah A., Wei Wang, Bryce A. Kerlin, and Sarah H. O’Brien. "Applying Diagnostic Criteria for Type 1 von Willebrand Disease to a Pediatric Population." Blood 110, no. 11 (November 16, 2007): 2138. http://dx.doi.org/10.1182/blood.v110.11.2138.2138.
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Abstract Background: Although type 1 von Willebrand disease (VWD) is the most common bleeding disorder seen by pediatric hematologists, making a definitive diagnosis continues to be a challenge in clinical practice. Both the International Society on Thrombosis and Haemostasis (ISTH) and the Hospital for Sick Children in Toronto (HSC) have proposed diagnostic criteria for type 1 VWD. These include abnormal laboratory values, significant mucocutaneous bleeding, and/or a positive family history. Most recently, the ISTH published updated recommendations, which differed only in the requirement of more abnormal laboratory results (VWF:Ag 5–20 IU/ml). We applied ISTH and HSC criteria, as well as updated ISTH criteria, to a large population of pediatric patients diagnosed with type 1 VWD. We hypothesized that a substantial number of patients would not meet either HSC or ISTH diagnostic criteria. Methods: We performed a retrospective medical record review of all type 1 VWD patients at our Hemostasis and Thrombosis Center. We evaluated each record for bleeding history, family history, and laboratory values. Frequencies of fit for HSC, ISTH and updated ISTH criteria were calculated. Mean VWF:Ag, VWF:RCo, and bleeding scores (Rodeghiero et al, J Thromb Haemost, 2006) were compared across populations meeting each proposed criteria. Results: Of 201 patients, 33.9% met the HSC definition of “definitive” type 1 VWD, 4.5% met ISTH definition, and 0% met updated ISTH definition. An additional 56.2% (HSC), 15.4% (ISTH), and 6% (updated ISTH) met definitions of “possible” type 1 VWD. For each proposed definition, criteria for significant mucocutaneous bleeding were most likely to be met, while criteria for abnormal laboratory values were least likely. In fact, 74% of patients had significant bleeding as defined by the HSC (56% as defined by ISTH). We did find significant clinical and laboratory differences between patients labeled as definite, possible, and normal by ISTH and HSC criteria. For example, patients meeting criteria for definite disease by HSC criteria had a mean bleeding score of 3.5 and mean VWF:Ag of 31 IU/ml, compared to 2.6 and 47 IU/ml in patients labeled as possible, and 2.2 and 68 IU/ml in patients labeled as normal (p=0.001 bleeding score, <0.001 mean VWF:Ag). Regardless of whether they met any set of criteria, most patients (94%) received some type of medical intervention (pre-operative or therapeutic desmopressin or VWF replacement). Discussion: We found that the majority of our pediatric type 1 VWD patients did not meet the original ISTH definition of definite or even possible type 1 VWD, thus confirming in a larger population the findings of HSC investigators (Dean et al, Thromb Haemost, 2000). In addition, we have demonstrated that the new ISTH criteria are even more inappropriate for clinical practice in a pediatric population, with 0% of patients meeting criteria for definite disease. Therefore, these criteria failed to identify a substantial number of children and adolescents who presented to medical attention, had significant mucocutaneous bleeding, and required therapeutic interventions. The new ISTH criteria may be an excellent scientific tool for identifying a narrow, severely affected population of patients likely to have autosomal dominant VWD mutations. However, they do not appear to have clinical validity in the pediatric setting.
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Shepherd, Bryan E., Hans-Peter Kiem, Cynthia E. Dunbar, Andre Larochelle, Robert E. Donahue, Ruth Seggewiss, Peter M. Lansdorp, Peter Guttorp, and Janis L. Abkowitz. "Estimating the Replication Rate of Hematopoietic Stem Cells in Non-Human Primates: A Test of Hayflick’s Hypothesis." Blood 106, no. 11 (November 16, 2005): 1710. http://dx.doi.org/10.1182/blood.v106.11.1710.1710.
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Abstract Because hematopoietic stem cells (HSC) cannot be directly observed, stochastic simulations in conjunction with competitive repopulation experiments have been used to estimate the replication rate of feline (1 rep per 8–10 wks) and murine (1 rep per 2.5 wks) HSC (model description and estimates in Nat Med2:190, 1996; Blood96:3399, 2001). These results could suggest that the HSC replication rate decreases with animal size and longevity, perhaps implying that the number of lifetime replications per HSC is limited and conserved in mammals. To test this, we analyzed retroviral vector gene marking and granulocyte telomere length data from baboons and rhesus macaques. Rhesus macaques are approximately the same size (weight 8 kg) as cats and have a similar lifespan (15–20 years); their hematopoietic demand, defined as the number of blood cells required per lifetime, is comparable. In contrast, baboons are larger (15 kg), live for 30 years, and have a hematopoietic demand more similar to humans. We simulated HSC dynamics for virtual baboons and macaques using specific HSC replication rates and then determined if observed data could be a random draw from 1000 simulated datasets. Compatibility of simulated and observed gene marking studies was determined by 3 formal criteria computed for both observed and simulated data: 1) the time after transplantation until the percent of marked cells stabilizes (measured using a change point model), 2) the presence or absence of drift after stabilization (drift is defined as a post-stabilization slope significantly different from 0 and estimated as at least 2% per 100 days), and 3) the amount of residual variation after stabilization (variation about a smoothed fit to the data -- transforming using the variance-stabilization transformation, arcsine of square root). Binomial probabilities were computed to evaluate Criterion 2 and Kolmogorov-Smirnov goodness of fit tests were used for evaluating Criteria 1 and 3, with p-values < 0.05 defining incompatibility. Mice and cat HSC parameters did not yield simulated data compatible with the observed baboon data. Rather, the analyses required that baboon HSC replicated less frequently, approximately once per 27–77 weeks (with 300 transplanted HSC (the estimated number infused); the range was robust to other modeling assumptions). In contrast, cat HSC parameters yielded simulated data compatible with the observed macaque data if 100–500 HSC were transplanted, whereas mice HSC parameters trended towards incompatibility (incompatible for 100 and 500 transplanted HSC; nearly incompatible for 300 transplanted HSC, p=0.07). Next, granulocyte telomere length data were simulated (methods in Exp Hematol32:1040; 2004) and preliminary data yielded best estimates for the replication rate of HSC in macaques and baboons of once per 18 weeks and once per 24 weeks, respectively. Our results (derived from 2 independent experimental approaches) demonstrate that the replication rate of macaque HSC is slower than mouse, whereas the replication rate of baboon HSC is slower than both cat and mouse; argue that the rate of HSC replication inversely correlates with longevity; and support Hayflick’s hypothesis that cells can only undergo a relatively constant finite number of lifetime replications. This apparent evolutionary constraint may extend to human HSC behavior.
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Agarwal, Sachin, Ravi Kant, and Ravi Shankar. "Humanitarian supply chain management frameworks." Benchmarking: An International Journal 26, no. 6 (August 5, 2019): 1749–80. http://dx.doi.org/10.1108/bij-08-2018-0245.
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Purpose The purpose of this paper is to examine and compare extant framework in humanitarian supply chain management (HSCM) and to propose a framework on humanitarian supply chain (HSC) performance measurement based on the content, context and process. Design/methodology/approach The structured keywords, namely humanitarian supply chain (HSC), humanitarian logistic (HL), humanitarian relief chain (HRC) and humanitarian chain (HC) as an exact phrase were searched in the title, abstract and keywords in the academic database. A total of 66 peer-reviewed articles were selected for analysis purpose that reports framework from the reviewed literature. These selected frameworks are categorized in dimensions, namely framework novelty, framework source, recognize elements/constructs of framework, comparative analysis of the framework and in-depth study of HSCM performance measurement. Findings The analysis reveals that the majority of these developed frameworks are novel and academic based. Case study is most prominent research methodology in the development of HSCM framework. Lack of coordination among humanitarian stakeholders is the major challenge in the empirical implementation of framework. This study proposes future research trend toward a unified HSCM framework that will facilitate to uncover the coherent set of elements/constructs in the field of HSCM. Research limitations/implications This study considers peer-reviewed articles published in English language, and excludes conference papers, working articles, technical data/reports and book chapters. Practical implications This study categorizes new dimension for framework analysis and proposed an HSC performance measurement framework which gives new insights to the academicians, practitioners and policy makers for future work. Social implications This examination gives the establishment to facilitate investigation of viable, efficient and effective HSCM, and detail opportunities for practices. Originality/value This study critically analyzes 66 frameworks under the different criteria to identify research gap and trends. Furthermore, this study proposes the HSC performance measurement framework.
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Szmigielska-Kaplon, Anna, Janusz Szemraj, Krzysztof Jamroziak, Agnieszka Pluta, Marta Robak, Anna Krawczynska, Katarzyna Hamara, Katarzyna Szmigielska, Tadeusz Robak, and Agnieszka Wierzbowska. "Polymorphism Of CD44 Influences Efficacy Of CD34+Cells Mobilization In Patients With Hematological Malignancies." Blood 122, no. 21 (November 15, 2013): 3270. http://dx.doi.org/10.1182/blood.v122.21.3270.3270.
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Abstract Background In the last decade peripheral blood was the main source of hematopoietic stem cells (HSC) for autologous (auto-SCT) and allogeneic (allo-SCT) transplantation. The exact mechanisms of HSC mobilization are still not clear and efficacy of the procedure is hardly predictable. Numerous clinical factors including age, number of previous intensive regimens, radiotherapy and type of disease can influence efficacy of CD34+ cell mobilization for auto-SCT in patients with hematologic malignancies. Recently it has been stated that ligand- receptor interactions of adhesion molecules such as SDF1/CXCR4, VLA4/VCAM-1 or CD44/osteopontin play important role in homing of HSC in hematopoietic niche. There is evidence that disruption of the ligand-receptor complex leads to egress of HSC to peripheral blood. Influence of single nucleotide polymorphisms in CD44, VCAM-1 and CXCR4 on efficacy of HSC mobilization was evaluated in healthy donors, but not in patients with hematological disorders. The aim of the present study was evaluation of constitutive polymorphism of genes encoding cytokines and receptors present in HSC niche and their impact on efficacy of mobilization of HSC in patients with hematological malignancies. Patients and Methods 110 (60 females and 50 males) were enrolled to the study. The median age of the patients was 55 (range 22-69) years. All of the patients evaluated were eligible for autologous HSC mobilization and transplantation. The group consisted of patients with multiple myeloma (74), non-Hodgkin lymphoma (19), Hodgkin lymphoma (15) or acute myeloid leukemia (2). The mobilization procedures comprised chemotherapy and then G-CSF at a dose of 10µg/kg daily. ‘Poor mobilizers’ group was defined according to GITMO criteria: patients with peak CD34+ in peripheral blood < 20/μL or total yield <2x 106 CD34+/kg in maximum 3 aphereses. Genotyping was performed using standard PCR-based assays. Three subgroups were established for the genotype in each polymorphism (homozygous more frequent, heterozygous and homozygous less frequent). Results The group of patients (N=108) who achieved minimal threshold for collections (CD34+ at least 10/µl) proceeded to aphereses. Median total yield of CD34+ in this group of patients was 5,6 x 106//kg, while median number of cells collected during first apheresis was 3,3x 106//kg. Median number of days of G-CSF treatment before first apheresis was 10. Fifteen patients fulfilled the criteria for ‘poor mobilizer’. The group of ‘poor mobilizers’ had higher frequency of TT allele in rs13347 (CD44) gene (CC+ CT vs TT p=0,047), the difference was even more pronounced in patients with multiple myeloma (N=72, p=0,027). TT homozygous genotype resulted in reduced CD44 mRNA expression at the time of apheresis in comparison with carries of C allele (median=40 in TT group, median=77 in CT and median=85 in CC group, p<0,001). Patients with TT allele had lower total yield CD34+/kg than the group with allele C (Median=3,7x 106//kg vs. 5,8x 106//kg, p=0.019) and lower number of CD34+cells gathered during first apheresis (0,95x 106//kg vs. 3,3x 106//kg, p=0.04). Multivariate logistic regression analysis including age, sex, diagnosis (multliple myeloma vs. others), number of previous treatment lines and CD44 polymorhism (TT vs CT+CC) revealed TT allele was the only factor associated with 5 fold higher risk of poor mobilization (p=0,037). Polymorphic variants of CXCR4 and VCAM-1 did not influence significantly efficacy of HSC mobilization in our group of patients. In conclusion, our results indicate that among investigated SNPs, only CD44 rs13347 has impact on efficacy HSC mobilization in patients with hematologic malignancies. CD44 SNPs analysis may be helpful for predicting of ‘poor mobilizers’ population that may benefit from newer modalities using adhesion molecules inhibitors. Disclosures: No relevant conflicts of interest to declare.
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McKinney-Freeman, Shannon, Hu Li, Matthew Curran, Sabine Loewer, Catherine Spina, Olaia Naveiras, James J. Collins, and George Q. Daley. "A Systems Biology Approach to Study the Acquisition of Adult Repopulating Potential During Hematopoietic Stem Cell Ontogeny." Blood 114, no. 22 (November 20, 2009): 1479. http://dx.doi.org/10.1182/blood.v114.22.1479.1479.
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Abstract Abstract 1479 Poster Board I-502 Hematopoietic progenitors and stem cells emerge at distinct times and anatomical locations during ontogeny. The first definitive hematopoietic progenitors appear in the yolk sac (YS) around day 8.5 of development (E8.5) while the first cells to meet the functional criteria of hematopoietic stem cell (HSC; cells capable of life-long restoration of the hematopoietic compartment of a recipient whose own hematopoietic system has been destroyed by chemicals or irradiation) can be detected in the aorta-gonads-mesonephros (AGM) at E10 of development. HSC can later be detected in large numbers in the E12.5 placenta, E14.5 fetal liver (FL) and adult bone marrow (BM). Induction of ectopic Cdx4 and HoxB4 expression during murine embryonic stem cell (ESC) differentiation followed by OP9 co-culture yields cells with in vivo hematopoietic repopulating potential (ESC-HSC). We have recently defined the phenotype of ESC-HSC relative to that of HSCs that arise in the embryo during development. Using cell fractionation followed by transplantation into irradiated Rag-2-/-γc-/- mice, we found that ESC-HSC display cell surface markers representative of both embryonic and adult HSC compartments: they express high levels of CD41, are heterogeneous for CD45, express CD150, and lack CD34 expression. We also found that CD150 is a developmentally regulated molecule on the surface of HSC, absent on the earliest HSC compartments of the AGM and placenta, but present on FL and bone marrow HSC. Although hematopoietic cells of the early YS do not display HSC potential when transplanted into the periphery of adult recipients, these cells can acquire this potential if infected with the homeobox gene HoxB4 and cultured on OP9 stroma, similarly to ESC. These data suggest that activation of specific molecular pathways can induce adult repopulating potential. To identify the critical genetic networks regulating the acquisition of adult hematopoietic repopulating potential, we are exploiting prospective purification via flow cytometry and microarray technology to assess the global gene expression profiles of HSC and progenitors from throughout murine ontogeny and embryonic stem cell differentiation. By comparing populations that lack adult repopulating potential (c-kit+CD41+CD34+ E9 YS cells, c-kit+CD41+CD45- ESC-derived cells and VE-cadherin+CD41- ESC-derived cells) with those that possess this activity (VE-cadherin+CD45+ E11.5 AGM, c-kit+CD34medCD45+ E12.5 placenta, Lin-c-kit+Sca-1+CD150+CD48- E14.5 FL, Lin-c-kit+Sca-1+CD150+CD34- BM, and CD41highCD45-CD34- cells from HoxB4 infected ESC expanded on OP9 stroma) we can use a novel gene network inference algorithm dubbed “mode-of-action by network identification” (MNI) to elucidate the key mediators for this functionality. The MNI algorithm predicts the key mediators under a particular perturbation by using a microarray compendium to infer a gene regulatory network that assesses how gene transcripts change in relation to one another and the net external influence. A large compendium with diverse experimental scenarios helps MNI to reverse engineer a comprehensive network model. We are currently using around 11,000 murine gene expression data sets acquired using 430 2.0 Affymetrix array chips to infer a regulatory network model, through which our HSC and progenitors microarray data will be filtered to identify the mode of action of the specific profiles accordingly. By comparing repopulating and non-repopulating populations from mouse ontogeny and ESC, we hope to identify the critical mediators and gene networks regulating the acquisition of adult repopulating potential during development. Disclosures: Daley: iPierian: Consultancy, Equity Ownership; Epizyme: Consultancy; Solasia: Consultancy; MPM Capital: Consultancy.
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Hawary, Amr M., Hazel E. Warburton, Richard J. Brough, Gerald N. Collins, Stephen C. Brown, Patrick H. O'Reilly, and Adebanji AB Adeyoju. "The ‘2-Week Wait’ Rule for Referrals for Suspected Urological Cancers – Urgent Need for Refinement of Criteria." Annals of The Royal College of Surgeons of England 90, no. 6 (September 2008): 517–22. http://dx.doi.org/10.1308/003588408x301082.
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INTRODUCTION All NHS-suspected cancers should be seen within 2 weeks of referral and are referred under government guidelines (Health Service Circular 205; HSC 205). This policy will be subject to review in 2009. Review is vital to allow the appropriate detection of malignancy without overburdening the premium clinic slots with the healthy. PATIENTS AND METHODS A total of 170 consecutive patients were referred from January–June 2005. Referral details, patient information, events and time to diagnosis were recorded. RESULTS Of these 170 patients, 143 were suitable for analysis. Forty-three patients (30%) were referred with frank haematuria, of whom 30% had bladder cancer. Nine percent of patients (n = 13) had microscopic haematuria none of whom had cancer. A quarter of the patients (n = 35) were referred with suspected testis cancer but none had cancer. Forty-one patients were referred with serum prostate-specific antigen (PSA) elevation; 18 cancers were detected in this group. Ten men had PSA values greater than 50 ng/ml. Only two cancers were suitable for radical prostatectomy. No cancer was found in patients less than 50 years of age. CONCLUSIONS A high cancer incidence was found (27.9%), the majority of which was bladder cancer or advanced prostate cancer. Out of the 143 patients, no malignancy was diagnosed in any patient less than 50 years of age, no malignancy was diagnosed in any of the microscopic haematuria group and there was no cancer diagnosed in the group of patients referred with scrotal swellings. We suggest that some guidelines are leading to referral of patients with low cancer risk. When the HSC 205 is revised in 2009, we hope studies such as ours are taken into consideration in order to improve resource utilisation.
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Park, Christopher Y., Yulei Wang, Susan Prohaska, Diane Tseng, and Irving L. Weissman. "MicroRNA Profiling of Human Acute Myeloid Leukemia and Normal Hematopoietic Stem/Progenitor Cells Reveals a Leukemia Stem Cell Signature." Blood 110, no. 11 (November 16, 2007): 779. http://dx.doi.org/10.1182/blood.v110.11.779.779.
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Abstract While numerous studies have contributed important insights into the molecular origins of human acute myeloid leukemia (AML), many may not accurately reflect molecular pathways critical to AML development or maintenance because they ignore the inherent heterogeneity among AML blasts. One subset of blasts - leukemia stem cells (LSCs) - exhibits the unique ability to self-renew and to engraft disease in immunodeficient mouse hosts, suggesting that their elimination is critical to developing curative therapies. In addition, there is little information regarding the role of microRNAs (miRNAs) in regulating gene expression or biologic function in AML. In order to assess the potential contribution of miRNAs to AML LSC biology, we have evaluated the expression profile of 315 mature miRNAs in FACS-purified AML LSC and compared it to both non-LSC blasts as well as normal human bone marrow (BM) derived hematopoietic stem cells (HSC) and committed progenitors using a multiplexed TaqMan-based real-time PCR strategy. SAM analysis with stringent criteria (at least 25% samples with Ct <30, FDR <1%) reveals that AML LSC and non-LSC blasts are more similar to one another than to normal HSC or committed progenitors. Among the BM populations tested, AML LSC and non-LSC populations are most similar to the granulocyte-macrophage progenitor (GMP). A set of miRNAs distinguishes AML LSC and non-LSC from normal HSC and committed progenitors, including 35 miRNAs that are under-expressed and 33 miRNAs that are over-expressed in both AML fractions versus the normal populations; many of these differentially expressed miRNAs show a range of expression exceeding 3 orders of magnitude. Supervised clustering analysis of AML LSC and non-LSC blasts reveals an LSC signature composed of 89 miRNAs, with nearly all differentially expressed miRNAs (86/89) exhibiting lower expression levels in AML LSC than non-LSC blasts. Finally, supervised clustering identifies a “stem-cell” signature composed of 17 miRNAs that are over-expressed in AML LSC and HSC versus committed progenitors. This group of miRNAs does not include miRNAs previously described as being highly expressed in embryonic stem cells. Together, these studies represent the first direct comparison of miRNA expression in a human cancer stem cell to its normal counterpart, thereby identifying miRNAs that may regulate AML LSC and/or normal HSC/committed progenitor function. Initial functional studies in vivo using LNA knockdown strategies indicate that a subset of miRNAs highly expressed in HSC and LSC is important in regulating normal HSC function. We are currently expanding these studies to test the role of these miRNAs in maintaining engrafted AMLs in the xenotransplant setting.
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To, L. Bik, Jean-Pierre Levesque, and Kirsten E. Herbert. "How I treat patients who mobilize hematopoietic stem cells poorly." Blood 118, no. 17 (October 27, 2011): 4530–40. http://dx.doi.org/10.1182/blood-2011-06-318220.
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Abstract Transplantation with 2-5 × 106 mobilized CD34+cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a proportion of patients/donors fail to mobilize sufficient cells. BM disease, prior treatment, and age are factors influencing mobilization, but genetics also contributes. Mobilization may fail because of the changes affecting the HSC/progenitor cell/BM niche integrity and chemotaxis. Poor mobilization affects patient outcome and increases resource use. Until recently increasing G-CSF dose and adding SCF have been used in poor mobilizers with limited success. However, plerixafor through its rapid direct blockage of the CXCR4/CXCL12 chemotaxis pathway and synergy with G-CSF and chemotherapy has become a new and important agent for mobilization. Its efficacy in upfront and failed mobilizers is well established. To maximize HSC harvest in poor mobilizers the clinician needs to optimize current mobilization protocols and to integrate novel agents such as plerixafor. These include when to mobilize in relation to chemotherapy, how to schedule and perform apheresis, how to identify poor mobilizers, and what are the criteria for preemptive and immediate salvage use of plerixafor.
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Yang, Liping, David Bryder, Jörgen Adolfsson, Jens Nygren, Robert Månsson, Mikael Sigvardsson, and Sten Eirik W. Jacobsen. "Identification of Lin–Sca1+kit+CD34+Flt3– short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients." Blood 105, no. 7 (April 1, 2005): 2717–23. http://dx.doi.org/10.1182/blood-2004-06-2159.
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AbstractIn clinical bone marrow transplantation, the severe cytopenias induced by bone marrow ablation translate into high risks of developing fatal infections and bleedings, until transplanted hematopoietic stem and progenitor cells have replaced sufficient myeloerythroid offspring. Although adult long-term hematopoietic stem cells (LT-HSCs) are absolutely required and at the single-cell level sufficient for sustained reconstitution of all blood cell lineages, they have been suggested to be less efficient at rapidly reconstituting the hematopoietic system and rescuing myeloablated recipients. Such a function has been proposed to rather be mediated by less well-defined short-term hematopoietic stem cells (ST-HSCs). Herein, we demonstrate that Lin–Sca1+kithiCD34+ short-term reconstituting cells contain 2 phenotypically and functionally distinct subpopulations: Lin–Sca1+kithiCD34+flt3– cells fulfilling all criteria of ST-HSCs, capable of rapidly reconstituting myelopoiesis, rescuing myeloablated mice, and generating Lin–Sca1+kithiCD34+flt3+ cells, responsible primarily for rapid lymphoid reconstitution. Representing the first commitment steps from Lin–Sca1+kithi CD34–flt3– LT-HSCs, their identification will greatly facilitate delineation of regulatory pathways controlling HSC fate decisions and identification of human ST-HSCs responsible for rapid reconstitution following HSC transplantations.
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Bourin, Philippe, Anne Huynh, Christian Recher, Christian Berthou, Laurent Garderet, Lofti Benbouker, Anne-Marie Perry, et al. "Stem Cell Factor (SCF) for Hematopoietic Stem Cell (HSC) Mobilization: Results of the Randomized IFM 99-01 Trial." Blood 104, no. 11 (November 16, 2004): 2921. http://dx.doi.org/10.1182/blood.v104.11.2921.2921.
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Abstract Introduction : In multiple myeloma, the usual mobilization protocol is toxic because of the use of cyclophosphamide. Several studies showed the interest of SCF. Objective : To compare two mobilization protocols: endoxan 4g/m2 + G-CSF 5μg/kg/j (arm A) versus G-CSF 10μg/kg/j + SCF 25μg/kg/j (arm B) in a prospective, open and, randomized trial. Patients and methods : the studied criteria were the quality of the cell collections (objective > 5.106 CD34+ cells into 2 cytapheresis), the toxicity of the mobilization and graft phases, as well as the post-graft hematopoietic reconstitution. Multiple myeloma patients, less than 65 years old, with 0 or 1 risk factor (ß2microglobulin > 3 mg/L or chromosome 13 deletion) and who have a response ≥ 50% after 3 cures of VAD were included. After a fourth cure of VAD each patient was planed to receive a tandem transplant (IFM 99-02 trial). Results : 150 patients (pts) were included and 138 were eligible (arm A = 67 pts, arm B = 71 pts). Pts and disease characteristics were similar in each arm. The objective of HSC collection was obtained with 92% pts in arm A and 81% pts in arm B (non significant). The total number of CD34+ cells collected were similar: 16.106 CD34+/kg (arm A) versus 15.106 CD34+/kg (arm B). Toxicity of HSC mobilization procedure was significantly different: duration of neutropenia < 500/mm3 (8 days in arm A versus 0 days in arm B, p<0.00001), duration of thrombopenia < 50 000/mm3 (5 days in arm A versus 0 days in arm B, p<0.0001), use of antibiotherapy (43% pts in arm A versus 9% pts in arm B, p<0.00001). 31% pts receiving SCF had local erythema at injection point. One pts experienced a grade 3 allergy in arm B. Hematopoietic reconstitution after first graft (high dose Melphalan 140 mg/m2, G-CSF at day 7) was not significantly different in either arm: duration of neutropenia < 500/mm3 (8 days in arm A versus 10 days in arm B), duration of thrombopenia < 50 000/mm3 (7.5 days in arm A versus 9 days in arm B), number of red blood cells units transfusions (1.5 versus 1.5). The 36 months overall survival probability was not significantly different with HDC mobilization (64%) versus SCF + G-CSF mobilization (87%). Conclusion : In myeloma patients, HSC mobilization with SCF + G-CSF is as effective as HDC + G-CSF, and gives very significant lower toxicities.
Dissertations / Theses on the topic "HSC criteria"
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Dixon, Wendy P. "Selection procedures relating to Australian vocal repertoire for mid-adolescent HSC performers." University of Sydney, 2007. http://hdl.handle.net/2123/1590.
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Master of Music (Music Education)This thesis documents an investigation of the selection procedures relating to Australian vocal repertoire for mid-adolescent and Higher School Certificate (New South Wales) performers, as used by private singing teachers, school music teachers and singing students. It explores the similarities and differences in the criteria employed in these selections. Semi-structured interviews were the source of data and were conducted with participants from these three categories as well as two composers. The participants evinced highly disparate views. The private singing teachers believed that repertoire should be dictated by the technical ability and physiological constraints of mid-adolescent students and that their role in selecting repertoire was related to the long term vocal growth of each individual. They felt that the school music teachers vetted their repertoire choices with no useful explanation of their reasoning, while the school music teachers noted that students frequently presented repertoire that was too difficult or that was not readily communicated with the audience. The ability of mid-adolescent singers to communicate with and engage an audience was the prime concern of the school music teachers. The students wanted to impress their examiners and believed that infrequently heard repertoire was the best choice, though this was not endorsed by the teachers. There was a perception that the students would perform at their best when they chose repertoire to which they could relate emotionally. Many private singing teachers and school music teachers are not aware of the very broad range of contemporary Australian music and its divergent characteristics. However, there is a shortage of appropriate Australian repertoire that addresses the physiological and emotional needs of mid-adolescent singers.
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Ulibarri, Roy M. "Habitat Suitability Criteria for Zuni Bluehead Sucker Catostomus discobolus yarrowi and Navajo Nation Genetic Subunit Bluehead Sucker Catostomus discobolus and Comparing Efficiency of AFS Standard Snorkeling Techniques to eDNA Sampling Techniques." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/604876.
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I quantified habitat selection for the endangered Zuni Bluehead Sucker Catostomus discobolus yarrowi and the Navajo Nation Genetic Subunit (NNGS) Bluehead Sucker Catostomus discobolus - a recent taxon described from genetic information. Both taxa are found in northern Arizona and New Mexico border regions. I examined fish [≥50 millimeters (mm) total length (TL)] selection of microhabitat conditions (i.e., water velocity, substrate size, overhead cover, water depth, instream cover, and mesohabitat conditions [i.e., pool, run riffle], during summer base flow conditions for NNGS Bluehead Suckers, and during both summer base flow and high spring flow conditions for Zuni Bluehead Suckers in six streams). Electrofishing, seining, and snorkeling were used to evaluate fish occupancy. From this information, I developed stream specific habitat suitability criteria (HSC) and then generalized HSC for each taxon, and tested transferability of the generalized HSC to individual streams. Zuni Bluehead Suckers and NNGS Bluehead Suckers occupied similar habitats: low velocity pools; sand, silt, and pebble substrate; high percent of instream cover; and water temperatures ranging from 2-21°C. However, Zuni Bluehead Suckers selected for low (0-25%) overhead cover where as NNGS Bluehead Sucker selected for high (0-75%) overhead cover. This was likely due to the source of instream cover–aquatic macrophytes that required sunlight in the Zuni Bluehead Sucker streams, and large woody debris falling from overhead branches in the NNGS Bluehead Sucker streams. Suggestions for managers includes maintaining existing cover or artificially construct additional instream cover; promote overhead cover (e.g., maintaining large trees along streams) and pool mesohabitats. In addition to this work I also tested the new method of environmental DNA (eDNA) to further help conservation efforts for these taxa. Environmental DNA has typically been used to detect invasive species in aquatic environments through water samples. I compared the efficacy of eDNA methodology to American Fisheries Society standard snorkeling surveys to detect presence of a rare fish species. My study site included three streams on the Navajo Nation in northern Arizona and northern New Mexico containing Navajo Nation Genetic Subunit Bluehead Sucker Catostomus discobolus and the Zuni Bluehead Sucker Catostomus discobolus yarrowi. To determine sample sites, I first divided entire wetted area of streams into 100-m consecutive reaches. I systematically selected 10 of those reaches for snorkel and eDNA surveys. Water samples were taken in 10-m sections within each 100-m reach, and fish presence via snorkeling was noted in each 10-m section as well. Water samples were collected at the downstream starting point of each reach, and continued upstream in each section 5 to 8 m ahead of the snorkeler. A qPCR was run on each individual water sample in quadruplicate to test for sucker presence or absence. I was able to positively detect both species with eDNA sampling techniques in two out of three streams. Snorkeling resulted in positive detections of both species in all three streams. In streams where fish were detected with eDNA sampling, snorkeling detected fishes at 11-29 sites per stream, where as eDNA detected fish at 3-12 sites per streams. My results suggested that AFS standard snorkeling was more effective at detecting target fish species than eDNA. To improve eDNA sampling, the amount of water collected and tested should be increased. Additionally, filtering water on site may improve eDNA techniques for detecting fish. Future research should focus on standardizing eDNA sampling to provide a widely operational sampling tool similar to electrofishing, netting, and hydroacoustics.
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Milz, Geoffrey G. "Beyond Ad-Hoc an application of multiple criteria decision analysis in emergency planning and response /." Cincinnati, Ohio : University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1212072805.
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Thesis (Master of Community Planning)--University of Cincinnati, 2008.Advisors: Carla Chifos Ph.D. (Committee Chair), Dan Peterson Ph.D. (Committee Member), Tonya Nichols Ph.D. (Committee Member) Title from electronic thesis title page (Sept. 6, 2008). Includes abstract. Keywords: multiple criteria decision analysis; emergency planning; analytic hierarchy process Includes bibliographical references.
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Gajurel, Sanjaya. "Multi-Criteria Direction Antenna Multi-Path Location Aware Routing Protocol for Mobile Ad Hoc Networks." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1197301773.
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MILZ, GEOFFREY G. "Beyond Ad-Hoc: An Application of Multiple Criteria Decision Analysis in Emergency Planning and Response." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1212072805.
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Jorgic, Milenko. "Localized criteria for detection of critical nodes and links and k-connectivity in ad hoc networks." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27463.
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Ad hoc network normally has critical connectivity properties before partitioning. The timely recognition is important in order to perform some data or service replication. Several existing centralized or globalized algorithms declare an edge or a node as critical if their removal will separate the network into several components. We introduce several localized definitions of critical nodes and critical links, using topological or positional information. A node is critical if the subgraph of p-neighbours of node (without the node itself) is disconnected. We propose three definitions of critical links, based on verifying common p-hop neighbours, loop length, and critical status of link endpoints, respectively. The experiments with random unit graph model of ad hoc networks show high correspondence of local and global decisions. Existing algorithms for testing k-connectivity are centralized. In this thesis, we introduce localized criteria for testing k-connectivity. In the first proposed local neighbor detection (LND) criterion, each node verifies whether or not itself and each of its p-hop neighbors have at least k neighbors. In the second local critical node detection (LCND) protocol, it also tests if the subgraph of its p-hop neighbours of a given node is k-connected. The third local subgraph connectivity detection (LSCD) protocol is based on communications between neighboring nodes to exchange the local decisions starting from k=1. All nodes declare themselves locally 1-connected. For k=2,3,..., iteratively, local decisions are propagated to p-hop neighbors. If node A is (k-1)-connected, all its p-hop neighbors are (k-1)-connected, and the graph consisting of p-hop neighbors of A (excluding A) is (k-1)-connected, then node A declares its neighborhood as k-connected. The experiments are carried with two ways of uniform generation of connected unit disk graphs. They show low percentage of false 'alarms', ability to locate critical areas in k-disconnected networks, and increased accuracy with increased local knowledge.
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Di, Teodoro Alessandro. "Teoria dei giochi e Multi-criteria decision-making per reti mobili Ad-hoc: un protocollo di routing." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/6594/.
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Nell'elaborato si analizzano aspetti della teoria dei giochi e della multi-criteria decision-making. La riflessione serve a proporre le basi per un nuovo modello di protocollo di routing in ambito Mobile Ad-hoc Networks. Questo prototipo mira a generare una rete che riesca a gestirsi in maniera ottimale grazie ad un'acuta tecnica di clusterizzazione. Allo stesso tempo si propone come obiettivo il risparmio energetico e la partecipazione collaborativa di tutti i componenti.
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Wayland, Robert F. (Robert Franklin). "Criteria by Which Ad Hoc Labor Arbitrators are Selected by Union and Management Advocates in the Petroleum Refining Industry." Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc331537/.
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A non-experimental, descriptive study was conducted to examine the criteria by which ad hoc labor arbitrators are selected in the petroleum refining industry. Three factors — arbitrator background, recognition, and arbitration practice — were examined to determine their relative importance to advocates selecting ad hoc labor arbitrators. The population of the study consisted of management and labor union advocates in the petroleum refining industry who routinely select ad hoc labor arbitrators.
Participating management and union advocates completed a questionnaire used to gather respondents' evaluations of criteria considered in the selection of ad hoc arbitrators. Responses to statements designed for measuring relative importance of the criteria considered were recorded. Descriptive statistics, discriminant analysis, and tests of significance were used in the treatment of the data.
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Osathanunkul, Kitisak. "A cross-layer and multi-metric routing decision making framework for MANETs." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/a-crosslayer-and-multimetric-routing-decision-making-framework-for-manets(747a6389-d354-4afc-8810-c4e781662107).html.
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Mobile Ad hoc Networks (MANETs) are re-emerging as a popular networking facility for wireless device users. A growing number of diversified applications are now accessible via wireless devices. The different applications may have different Quality of Service (QoS) requirements, which may better be satisfied by using different routing methods or metric types. Existing ad hoc network routing solutions do not consider various application-level requirements when making a routing decision. They typically make routing decisions based upon limited information acquired at the network layer. Most of the existing routing protocols make use of a single routing metric. Using a single metric type and/or information, only acquired at the network layer may not be able to accommodate different QoS requirements, imposed by diversified user-level applications or application-level data types.The aim of this thesis is to design an efficient routing function for ad hoc networks while at the same time satisfying users‟ and/or applications‟ QoS and security requirements. To achieve this, the thesis investigates and specifies routing requirements that could best support application-level QoS and security requirements in MANETs. It also investigates and critically analyses the state of the art in MANET routing, and the mechanisms used for protecting the routing functions. To overcome the weaknesses and advance the state of the art in MANET routing, this thesis proposes two major solutions. The first solution is the Secure ETX (SETX) routing protocol. It is a secure routing solution that can provide routing functions efficiently in malicious MANET environment. The SETX protocol provides a security mechanism to counter black hole attacks in MANETs on the ETX metric acquisition process. Simulation studies have been carried out and discussed in the thesis. Simulation results show that the SETX protocol can provide a marked improvement in network performances in the presence of black hole attacks, and it can do so with a negligible level of additional overhead.The second solution is a novel routing decision making called the Flexible Routing Decision (FRD) framework. The FRD framework supports routing decision making by using multiple metric types (i.e. multi-criteria routing decision making) and uses a cross-layer approach to support application-level QoS requirements. This allows users to use different routing metrics types, making the most appropriate routing decision for a given application. To accommodate the diversified application-level QoS requirements, multiple routing metric types have been identified and interpreted in the FRD framework design. The FRD framework has overcome some weaknesses exhibited by existing single metric routing decision making, used in MANETs. The performance of a routing decision making of FRD is also evaluated using NS2 simulation package. Simulation results demonstrate that the FRD framework outperforms the existing routing decision making methods.
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Trosseille, Xavier. "Contribution a la recherche d'une alternative au critere de tolerance cerebrale (hic) dans un environnement automobile." Paris, ENSAM, 1992. http://www.theses.fr/1992ENAM0015.
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Les lesions cranio-encephaliques restent, malgre le port de la ceinture de securite, une des atteintes les plus frequentes de l'occupant d'un vehicule lors d'un accident de la circulation. Or, il n'existe pas actuellement de critere de tolerance pertinent prenant en compte les multiples mecanismes lesionnels. Le but de cette recherche est de contribuer a la mise au point d'un modele qui, a partir des mesures effectuees sur mannequin lors d'essais de chocs, permette de predire le risque lesionnel pour le cerveau, ou de comprendre les mecanismes intervenant. La premiere phase du travail a consiste a modeliser la tete, tout d'abord par un modele discret donnant les premiers modes de vibration du cerveau, puis ensuite par modele elements finis, de facon a decrire dans toute sa complexite le comportement du cerveau dans la boite cranienne. Pour ce faire, un protocole experimental sur cadavre a ete mis au point. Des essais ont ete realisee et une etude parametrique a ete effectuee pour evaluer et tenter d'ameliorer un modele deja existant. La deuxieme phase du travail doit permettre de determiner des seuils de tolerance. Pour cela, des experimentations sur boxeurs volontaires ont ete menees a bien. Les essais ont consiste a mesurer les accelerations lineaires et angulaires de la tete des boxeurs lors de coups recus pendant des matchs d'entrainement. La simulation des coups par le modele e. F. Etudie dans la premiere partie a permis d'obtenir une sous-estimation des tolerances. Pour finir, une application de cette etude a un moyen de protection de la tete a ete realisee par simulation, a l'aide du modele e. F. , d'impacts de tete sur volant ou sur sac gonflable
Books on the topic "HSC criteria"
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Peter, Brown. BTEC HNC HND business. London: BPP Pub., 1996.
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Food and Agriculture Organization of the United Nations. Ad Hoc Expert Meeting on Indicators and Criteria of Sustainable Shrimp Culture. Report of the Ad Hoc Expert Meeting on Indicators and Criteria of Sustainable Shrimp Culture: Rome, Italy, 28-30 April 1998 = Rapport de la réunion ad hoc d'experts sur les indicateurs et critères relatifs à l'èlevage durable des crevettes : Rome, Italie, 28-30 avril 1998 = Informe de la Reunión Especial de Expertos Técnicos Sobre Indicadores y Criterios Para el Cultivo Sostenible del Camarón : Roma, Italia, 28-30 de abril de 1998. Rome: Food and Agriculture Organization of the United Nations, 1998.
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P, Standing, and Great Britain. Health and Safety Executive., eds. 1,1,1,2-tetrafluoroethane HFC 134a: Criteria document for an occupational exposure limit. Sudbury: HSE Books, 1995.
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Eleftheriou, Despina, and Paul A. Brogan. Paediatric vasculitis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0136.
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Systemic vasculitis is characterized by blood vessel inflammation which may lead to tissue injury from vascular stenosis, occlusion, aneurysm, and/or rupture. Apart from relatively common vasculitides such as Henoch-Schönlein purpura (HSP) and Kawasaki's disease (KD), most of the primary vasculitic syndromes are rare in childhood, but are associated with significant morbidity and mortality. New classification criteria for childhood vasculitis have recently been proposed and validated. The cause of most vasculitides is unknown, although it is likely that a complex interaction between environmental factors such as infections and inherited host responses trigger the disease and determine the vasculitis phenotype. Several genetic polymorphisms in vasculitis have now been described that may be relevant in terms of disease predisposition or development of disease complications. Treatment regimens continue to improve, with the use of different immunosuppressive medications and newer therapeutic approaches such as biologic agents. We provide an overview of paediatric vasculitides focusing on HSP, KD, and polyarteritis nodosa (PAN). Key differences (where relevant) between paediatric and adult vasculitis are highlighted. In addition we discuss new emerging challenges particularly in respect to the long-term cardiovascular morbidity for children with systemic vasculitis, and emphasize the importance of future international multicentre collaborative studies to further increase and standardize the scientific base of investigating and treating childhood vasculitis.
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Smet, Stijn. Conflicts between Human Rights and the ECtHR. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198795957.003.0003.
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This chapter proposes a structured balancing test for the resolution of human rights conflicts. The chapter first critiques the European Court of Human Right’s ad hoc balancing approach to human rights conflicts. Analysis of a pair of concrete judgments—Obst v. Germany and Schüth v. Germany—illustrates the shortcomings of that approach. The chapter then proposes an alternative, structured balancing test. The structured balancing test, composed of a limited set of seven balancing criteria, relies on comparison of the relative strength of reasons in favour of conflicting human rights to determine which right should prevail in a given conflict. By doing away with contested balancing notions, such as ‘weight’ and ‘scales’, the structured balancing test also aims to overcome the incommensurability challenge to balancing. The test is finally applied to Obst and Schüth to illustrate how its use could improve the Court’s adjudicatory practice.
Book chapters on the topic "HSC criteria"
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Byrne, Thomas, and Hugo Vargas. "HCC: The San Francisco Criteria." In Contemporary Liver Transplantation, 287–91. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-07209-8_12.
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Byrne, Thomas, and Hugo Vargas. "HCC: The San Francisco Criteria." In Contemporary Liver Transplantation, 1–5. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05543-5_12-1.
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Byrne, Thomas, and Hugo Vargas. "HCC: The San Francisco Criteria." In Contemporary Liver Transplantation, 1–5. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05543-5_12-2.
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Civan, Jesse M. "Liver Transplantation for HCC: The Milan Criteria." In Contemporary Liver Transplantation, 267–86. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-07209-8_11.
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Civan, Jesse M. "Liver Transplantation for HCC: The Milan Criteria." In Contemporary Liver Transplantation, 1–20. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05543-5_11-1.
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Civan, Jesse M. "Liver Transplantation for HCC: The Milan Criteria." In Contemporary Liver Transplantation, 1–19. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05543-5_11-2.
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Mellander, H. "HIC—the Head Injury Criterion." In Modern Concepts in Neurotraumatology, 18–20. Vienna: Springer Vienna, 1986. http://dx.doi.org/10.1007/978-3-7091-8859-0_6.
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Ganjoo, Naveen, and Thomas D. Schiano. "Recurrence of HCC When Transplanted Outside Milan Criteria." In Disease Recurrence After Liver Transplantation, 165–86. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-2947-4_12.
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Laurindo, Suelen, Ricardo Moraes, Carlos Montez, and Francisco Vasques. "Multi-criteria Analysis to Select Relay Nodes in the ORST Technique." In Ad-Hoc, Mobile, and Wireless Networks, 167–82. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-31831-4_12.
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García, Juan Carlos, Stefan Beyer, and Pablo Galdámez. "A Stability Criteria Membership Protocol for Ad Hoc Networks." In On the Move to Meaningful Internet Systems: OTM 2009, 690–707. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-05148-7_49.
Full textConference papers on the topic "HSC criteria"
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He, Qing, Fuzhen Zhuang, and Zhongzhi Shi. "The Data Selection Criteria for HSC and SVM Algorithms." In 2008 Fourth International Conference on Natural Computation. IEEE, 2008. http://dx.doi.org/10.1109/icnc.2008.334.
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Mørch, Hans Jørgen, Thomas Larsen, Erik Mostert, Karl Marius Norschau, and Gunnar Semb. "Full Scale Measurements and Flow Analysis on a High Speed Rescue/Patrol Boat." In SNAME 13th International Conference on Fast Sea Transportation. SNAME, 2015. http://dx.doi.org/10.5957/fast-2015-042.
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Through use of state of the art tools for flow analysis the aims to establish a methodology to determine the performance of a high speed planing craft both in calm water and in waves. Verification against full scale measurements is conducted. The ability to maintain speed in waves is of great interest -both with respect to added resistance and with respect to safe operation and loads on the crew from accelerations. Full scale measurements and CFD (Computational Fluid Dynamics) were conducted on a Norsafe Magnum 850fast patrol boat. The measurements have been conducted during a boat challenge along the Iberian coast. The challenge was run in advance of the HSBO (High Speed Boat Forum) which was held in Lisbon, Portugal, May2015.CFD simulations at similar conditions to the measurements are used for validation. It is further shown how CFD can be used to expand operational envelopes beyond the point where full scale measurements are applicable. This is especially relevant for the acceleration loads on the crew which is often the limiting factor of small HSC (High Speed Crafts). Pressure loads are extracted from the CFD and are evaluated against the current standards for life boats. Various criteria are discussed and the most relevant are analyzed for the measurement results and the CFD simulation. An operational envelope where the different criteria are combined is suggested.
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Eager, David, Hasti Hayati, and Chris Chapman. "Impulse Force as an Additional Safety Criterion for Improving the Injury Prevention Performance of Impact Attenuation Surfaces in Children’s Playgrounds." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-65565.
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More than four decades has passed since introducing safety standards for Impact Attenuation Surfacing (IAS) used in children’s playgrounds. Falls in children’s playgrounds is a major source of injuries and IAS is one of the best safety interventions deployed to reduce the incidence and severity of these injuries. Currently there are two criteria that measure the injury prevention performance of IAS, namely: Head Injury Criteria (HIC); and maximum acceleration (Gmax). Based on the ASTM playground safety standard F1292 the thresholds of HIC and Gmax are 1000 and 200g respectively. If the playground IAS complies with this Standard the number and severity of fall-related injuries in playgrounds should be decreased. However after implementing these standards a high number of children continue to be hospitalized due to fall-related playground injuries In this paper we tested ten samples based on ASTM F1292 standard to propose the introduction of an additional criterion to HIC and Gmax which can filter and remove hazardous IAS that technically comply with the current 1000 HIC and 200g safety thresholds. The proposed criterion is called the impulse force criterion (If) and combines the change of the momentum and the impact duration. The Gmax, HIC and If results are presented graphically and numerically.
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Saboori, Parisa, Shahab Mansoor-Baghaei, and Ali M. Sadegh. "Evaluation of Head Injury Criteria Under Different Impact Loading." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-65125.
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The Head Injury Criterion (HIC) has been employed as a measure of traumatic brain injury arising from an impact involving linear acceleration. Some investigators have been reported the shortcomings of the HIC regarding the angular accelerations, head mass and the precise threshold of injury level [1, 2]. In this study the effect of acceleration curves, as a frontal impact, and the HIC values on the strain in the brain was critically analyzed. Specifically in this paper, the strains in the brain for three sets of acceleration pulses, where the peak of the curve takes place early or later (advanced or delayed) during the pulse time, were investigated. The results of this study indicate that for two different acceleration pulses, with the same peak value, duration and the same HIC values the strains in the brain are different. Therefore there is a need for further research leading to better criteria or modification of the HIC as it relates to the Traumatic Brain Injury (TBI).
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Lankarani, Hamid M., C. S. Koshy, and C. K. Thorbole. "Design and Validation of a Component Head Injury Criteria Tester for Aerospace Applications." In ASME 2005 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/detc2005-84436.
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The compliance with Head Injury Criteria (HIC) specified in 14 CFR 23.562 [1] and CFR 25.562 [2] poses a significant problem for many segments of the aerospace industry. The airlines and the manufacturers of jet transports have made claims of high costs and significant schedule overruns during the development and certification of 16G seats because of the difficulties encountered in meeting this requirement. The current practice is to conduct Full Scale Sled Tests (FSST) on impact sleds. This approach can be expensive, since a new seat may be needed for each test. Moreover, some consider the HIC sensitive to changes in the test conditions, such as sled pulse, seat belt elongation, etc., resulting in HIC results from FSSTs showing poor repeatability. These difficulties make it desirable to devise a cheaper, faster, and more repeatable alternative to FSSTs. This paper describes an attempt to address these issues by designing a device, the National Institute for Aviation Research (NIAR) HIC Component Tester (NHCT) using various multibody tools. This device was then fabricated and its performance evaluated against FSSTs conducted under similar test conditions for some typical impact events that occur in an aircraft cabins e.g. impact with bulkheads. The factors compared for this evaluation are the head impact angle, head impact velocity, HIC, HIC window, peak head C.G. resultant acceleration, average head C.G. resultant acceleration, and head C.G. resultant acceleration profiles. The results of these evaluations show that the NHCT already produces test results that correlate significantly with FSST results for impact targets such as bulkheads and its target envelope is expected eventually to include objects such as seat backs.
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Zhang, Jiangyue, Narayan Yoganandan, and Frank A. Pintar. "Translational and Rotational Head Kinematics in Side Impact." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206140.
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Regulatory tests use translational head accelerations and its derived variable HIC (head injury criterion) as the criteria for automotive vehicle crashworthiness evaluation. The FMVSS standard sets HIC36 of 1000 as the threshold for frontal impact protection. On the other hand, rotational head kinematics, such as rotational accelerations and velocities, has been attributed to brain injury in the motor vehicle environment for more than six decades [1–5]. As documented in recent real-world case studies, severe brain injuries without skull fracture, such as diffuse axonal injury, can result from rotational head motions in side impacts even at low change in impact velocity [6, 7]. Because the HIC only accounts for the translational head accelerations, there is no clear evidence showing there is a direct correlation between translational and rotational head acceleration. Therefore, it is important to quantify the correlation between head translational and rotational accelerations and HIC, in side impacts. Consequently, the current research was designed with this purpose.
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Boksiner, Jeffrey, Yuriy Posherstnik, and Richard O. Yeager. "Interference criteria for Mobile Ad-Hoc Networks." In MILCOM 2015 - 2015 IEEE Military Communications Conference. IEEE, 2015. http://dx.doi.org/10.1109/milcom.2015.7357645.
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Cassenti, Lawrence, and P. E. Peter Leed. "Criterra automatic location planning." In 2011 IEEE International Conference on Technologies for Homeland Security (HST). IEEE, 2011. http://dx.doi.org/10.1109/ths.2011.6107873.
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Barritt, Brian, Behnam Malakooti, and Zhihao Guo. "Intelligent Multiple-Criteria Broadcasting in Mobile Ad-hoc Networks." In 2006 31st IEEE Conference on Local Computer Networks. IEEE, 2006. http://dx.doi.org/10.1109/lcn.2006.322034.
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Kaur, Navneet, and Sandeep Kad. "Cluster connectivity selection criteria in vehicular ad hoc networks." In 2016 2nd International Conference on Contemporary Computing and Informatics (IC3I). IEEE, 2016. http://dx.doi.org/10.1109/ic3i.2016.7917993.
Full textReports on the topic "HSC criteria"
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Sampson, M. Compilation of Criteria and Summaries from B332 Seismic Evaluations for the Initial Scoping Document Release of the HS-45 LLNL Audit, February 7, 2013. Office of Scientific and Technical Information (OSTI), February 2013. http://dx.doi.org/10.2172/1122218.
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