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Wahlgren, G. M., K. E. Nielsen, and D. S. Leckrone. "High-resolution spectroscopy of the hot Am star HR 3383." Monthly Notices of the Royal Astronomical Society 500, no. 2 (October 27, 2020): 2451–60. http://dx.doi.org/10.1093/mnras/staa3323.
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ABSTRACT We present the spectrum analysis of the hot Am star HR 3383 (A1 Vm). Hubble Space Telescope STIS and Nordic Optical Telescope SOFIN data are modelled with synthetic spectra, and abundances are investigated for 78 elements. Most light elements up through oxygen show deficiencies, compared to solar abundances, followed by the general trend of increasing abundance enhancement with atomic number that levels off at a 30-fold enhancement at the lanthanide group and heavier elements. The derived element distribution is generally consistent with what is observed in other hot Am stars. Abundances for HR 3383 are also similar to what is seen for the cooler HgMn stars, with the exception of the platinum-group elements that generally show dramatic enhancements in the HgMn stars. Current theory and calculations are able to predict most observed abundances and abundance trends through the iron group. The large number of derived element abundances in this study provides a constraint for theoretical calculations attempting to explain the heavy element abundances in chemically peculiar stars. This paper includes a comprehensive description of spectral lines useful for an abundance analysis of late B and A type stars, and comments are provided on the atomic data. New data for hyperfine structure components for three lines in Lu iii and a single line in Lu ii are presented, based on laboratory spectra. In addition to the stellar spectrum, lines from the interstellar medium are noted for several of the strongest Fe ii ultraviolet transitions.
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Martins, Fernanda Andrade, Alanderson Alves Ramalho, Andréia Moreira de Andrade, Simone Perufo Opitz, Rosalina Jorge Koifman, and Ilce Ferreira da Silva. "Padrões de amamentação e fatores associados ao desmame precoce na Amazônia ocidental." Revista de Saúde Pública 55 (May 17, 2021): 21. http://dx.doi.org/10.11606/s1518-8787.2021055002134.
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OBJETIVO: Caracterizar os padrões de amamentação nos primeiros seis meses de vida e fatores associados ao desmame precoce numa coorte de nascidos vivos em Rio Branco, Acre. MÉTODOS: Estudo prospectivo com nascidos vivos entre abril e junho de 2015. As entrevistas com as mães ocorreram logo após o nascimento e entre 6 e 15 meses pós-parto. Na alta hospitalar, o aleitamento foi definido em exclusivo (AME) e materno (AM). No seguimento, os padrões de amamentação foram AME, aleitamento materno predominante (AMP) e AM. A interrupção da amamentação nos primeiros seis meses foi classificada como desmame precoce. Utilizou-se o método de Kaplan Meier (log-rank: 95%) para estimar a probabilidade condicional de mudança no padrão de amamentação e risco de desmame. Os fatores associados ao desmame e seus intervalos de confiança de 95% (IC95%) foram analisados pela regressão proporcional de Cox bruta e ajustada. RESULTADOS: Participaram do estudo 833 lactentes que na alta hospitalar estavam em AME (95,4%) e AM (4,6%). A probabilidade do lactente em AME na alta hospitalar permanecer em AME, ou se tornar AMP ou AM, aos seis meses, foi de 16,4%, 32,3% e 56,5% respectivamente. A probabilidade de desmame aos seis meses foi estaticamente maior para lactentes em AM na alta hospitalar (47,4%) em comparação com aqueles em AME (26%). Mostraram-se associados ao desmame precoce: o AM na alta hospitalar (HR = 1,82; IC95% 1,06–3,11), ausência de amamentação cruzada praticada pela mãe (HR = 2,50; IC95% 1,59–3,94), usar chupeta (HR = 6,23; IC95% 4,52–8,60), pretender amamentar por menos de seis meses (HR = 1,93; IC95% 1,25–2,98), não amamentar na primeira hora de vida (HR = 1,45; IC95% 1,10–1,92) e consumir álcool na gestação (HR = 1,88; IC95% 1,34–2,90). CONCLUSÃO: Comparados aos lactentes em AME, aqueles em AM, na alta hospitalar, apresentaram maior probabilidade de desmame. Esforços em saúde pública devem priorizar o AME na alta hospitalar, promover amamentação na primeira hora de vida e orientar sobre os riscos do consumo de álcool na gestação, amamentação cruzada e uso de chupeta.
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Dumar, Amanda M., Anna F. Huntington, Rebecca R. Rogers, Thomas J. Kopec, Tyler D. Williams, and Christopher G. Ballmann. "Acute Beetroot Juice Supplementation Attenuates Morning-Associated Decrements in Supramaximal Exercise Performance in Trained Sprinters." International Journal of Environmental Research and Public Health 18, no. 2 (January 7, 2021): 412. http://dx.doi.org/10.3390/ijerph18020412.
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Diurnal fluctuations in power output have been well established with power loss typically occurring in morning (AM) times. Beetroot juice (BRJ) is a source of dietary nitrate that possess ergogenic properties, but it is unknown if ingestion can mitigate performance decrements in the morning. The purpose of this study was to examine the effects of acute BRJ supplementation on diurnal fluctuations in anaerobic performance in trained sprinters. Male Division 1 National Collegiate Athletic Association (NCAA) sprinters (n = 10) participated. In a double-blinded crossover study design, participants completed three counterbalanced exercise trials under different conditions: Morning–placebo (8:00 HR, AM-PL), Morning–BRJ (8:00 HR, AM-BRJ), and Afternoon–no supplement (15:00 HR, PM). For each trial, participants completed 3 × 15 s Wingate anaerobic tests separated by 2 min of rest. Each trial was separated by a 72 h washout period. Mean power output (p = 0.043), anaerobic capacity (p = 0.023), and total work (p = 0.026) were significantly lower with the AM-PL condition compared to PM. However, BRJ supplementation prevented AM losses of mean power output (p = 0.994), anaerobic capacity (p = 0.941), and total work (p = 0.933) in the AM-BRJ compared to the PM condition. Rate of perceived exertion was not significantly different between any conditions (p = 0.516). Heart rate was significantly lower during the AM-BRJ condition compared to AM-PL (p = 0.030) and PM (p < 0.001). Findings suggest anaerobic capacity suffers during AM versus PM times in trained sprinters, but BRJ ingestion abolishes AM-associated decrements in performance.
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Dumar, Amanda M., Anna F. Huntington, Rebecca R. Rogers, Thomas J. Kopec, Tyler D. Williams, and Christopher G. Ballmann. "Acute Beetroot Juice Supplementation Attenuates Morning-Associated Decrements in Supramaximal Exercise Performance in Trained Sprinters." International Journal of Environmental Research and Public Health 18, no. 2 (January 7, 2021): 412. http://dx.doi.org/10.3390/ijerph18020412.
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Diurnal fluctuations in power output have been well established with power loss typically occurring in morning (AM) times. Beetroot juice (BRJ) is a source of dietary nitrate that possess ergogenic properties, but it is unknown if ingestion can mitigate performance decrements in the morning. The purpose of this study was to examine the effects of acute BRJ supplementation on diurnal fluctuations in anaerobic performance in trained sprinters. Male Division 1 National Collegiate Athletic Association (NCAA) sprinters (n = 10) participated. In a double-blinded crossover study design, participants completed three counterbalanced exercise trials under different conditions: Morning–placebo (8:00 HR, AM-PL), Morning–BRJ (8:00 HR, AM-BRJ), and Afternoon–no supplement (15:00 HR, PM). For each trial, participants completed 3 × 15 s Wingate anaerobic tests separated by 2 min of rest. Each trial was separated by a 72 h washout period. Mean power output (p = 0.043), anaerobic capacity (p = 0.023), and total work (p = 0.026) were significantly lower with the AM-PL condition compared to PM. However, BRJ supplementation prevented AM losses of mean power output (p = 0.994), anaerobic capacity (p = 0.941), and total work (p = 0.933) in the AM-BRJ compared to the PM condition. Rate of perceived exertion was not significantly different between any conditions (p = 0.516). Heart rate was significantly lower during the AM-BRJ condition compared to AM-PL (p = 0.030) and PM (p < 0.001). Findings suggest anaerobic capacity suffers during AM versus PM times in trained sprinters, but BRJ ingestion abolishes AM-associated decrements in performance.
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Goss, G. D., C. Addison, F. Shepherd, L. Seymour, A. LeMaitre, and K. Ding. "TGF-α and amphiregulin levels in non-small cell lung cancer (NSCLC) patients (pts) treated with erlotinib/placebo in the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) BR.21." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 11023. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11023.
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11023 Background: In BR.21, erlotinib prolonged survival of previously treated NSCLC pts. We examined the predictive/ prognostic effects of the EGFR ligands, TGFa and amphiregulin(Am). Methods: Plasma was collected prior to treatment in consenting pts. TGFa and Am were analyzed by ELISA (R&D Systems). Samples were blinded, measured in duplicate and ligand concentrations determined following interpolation of a standard curve generated from known quantities of recombinant proteins. Sensitivity was ∼3pg/ml. Cutoff points for TGFa were <10 (low) and ≥10 (high); for Am <1.5 (low) vs 1.5–10 (intermediate) vs >10 (high). Standard statistical methods were used to correlate biomarker data with baseline characteristics and outcomes. Results: In 731 randomized pts, 539 were evaluable for both markers; there was a significant interaction (p=0.03) between the evaluable and inevaluable cohorts (erlotinib benefit favoring the evaluable cohort); evaluable pts were more likely to be male, > 60 and to have EGFR amplification. Baseline high TGFa was associated with poorer ECOG PS (p=0.03) while high Am was associated with worse PS (p<0.0001), anemia (p<0.0001), non response to prior therapies (p=0.01) and no-prior platinum therapy (p=0.02). Although TGFa was not prognostic for OS (HR=1.0, p=0.99), high Am was (HR: Middle vs low: 0.94, 95% C.I 0.49 -1.81; high vs.low: 2.04, 95% C.I 1.43 - 2.91; p=0.0002). High TGFa was a poor prognostic factor for PFS (HR 1.4, p=0.07) as was elevated Am (HR: Middle vs low: 1.02, 95% C.I 0.56 -1.85; high vs. low: 1.67, 95% C.I 1.19 - 2.35, p=0.01). In multivariate analyses including both ligands, high Am remained prognostic, but neither ligand was predictive. Conclusions: High levels of baseline Am appears to be a poor prognostic factor, while low levels of TGFa showed a trend to predict benefit from erlotinib in univariate analyses. [Table: see text] [Table: see text]
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Chotsampancharoen, Thirachit, Pornpun Sripornsawan, Sarapee Duangchu, Malai Wongchanchailert, and Edward McNeil. "Survival Outcome of Alternative Medicine Treatment for Newly Diagnosed Acute Leukemia in Children." Acta Haematologica 140, no. 4 (2018): 203–8. http://dx.doi.org/10.1159/000493417.
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Background: There is scarce information on the efficacy of alternative medicine (AM) alone as a treatment for newly diagnosed acute leukemia in children. We aimed to compare overall survival (OS) between children with newly diagnosed acute leukemia who received AM alone as the first-line treatment and those treated with conventional chemotherapy (CCT). Methods: Two-to-one nearest-neighbor propensity score-matching using sex, initial white blood cell count, phenotype of leukemia, and period of diagnosis was performed on 184 patients who received CCT and 92 who received AM alone after being diagnosed with leukemia. A multivariable Cox proportional-hazards regression model was then applied to assess the effect of treatment on OS after adjusting for potential confounders. Hazard ratios (HR) and 95% confidence intervals (CI) are provided. Results: After adjusting for initial white cell count and subtype of leukemia, children treated with AM alone had worse OS (HR 5.14, 95% CI 3.75–7.04) than those given CCT. The 5-year OS rate for newly diagnosed acute leukemia treated with AM medicine alone was 0%. Conclusion: AM without CCT is associated with poorer survival when compared with CCT.
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Lehnert, Volker, and Iris Dopfer-Hirth. "Datenschutzanforderungen und ihre Unterstützung in HR-Systemen am Beispiel SAP ERP HCM." HMD Praxis der Wirtschaftsinformatik 53, no. 6 (October 5, 2016): 851–65. http://dx.doi.org/10.1365/s40702-016-0267-0.
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Kilby, Greg. "Analysis of PTMs via Capillary LC Coupled with HR/AM Mass Spec." Genetic Engineering & Biotechnology News 36, no. 6 (March 15, 2016): 24–25. http://dx.doi.org/10.1089/gen.36.06.14.
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Somlo, George, Marcelo C. Pasquini, Beth Blackwell, Steven Michael Devine, Siddhartha Ganguly, Yvonne Efebera, Sergio Giralt, et al. "Response status as predictor of survival after autologous hematopoietic cell transplant (AHCT), without or with consolidation (with bortezomib, lenalidomide (Len) and dexamethasone) and len maintenance (AM vs. ACM) versus tandem AHCT and len maintenance (TAM) for up-front treatment of patients (pts) with multiple myeloma (MM): BMT CTN0702-stamina (NCT01109004)." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 8010. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.8010.
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8010 Background: The Stamina trial primarily aimed to identify the best strategy among AM, ACM, and TAM, leading to longer PFS (LBA-1, ASH, 2016). Here we report on interim, exploratory results of the association between PFS and overall survival (OS) and baseline MM response, risk category, and treatments (Rx). Methods: Pts with MM, < 71 years, < 12 mos from diagnosis were randomized to melphalan 200mg/m2(mel) and AHCT (AM), tandem mel AHCT (TAM), or mel AHCT and 4 cycles of RVD ((ACM). Pts received Len till progression. Pts were stratified by high risk vs. standard ( del13q, del17q, t(4;14), t(14;16), t(14;20) and hypodyploid; high β2 microglobulin). Kaplan Meier estimates of PFS and OS were performed as a function of Rx and ≥ very good partial response (VPGR including CRs) vs. < VGPR. Cox proportional hazard models explored associations between PFS or OS and risk category, Rx, and ≥ VPGR vs. < VGPR. Results: Between 6/2010-11/2013, 758 pts (AM, N = 257; ACM, N = 254; TAM, N = 247) aged 20-70 years (median 57y) were enrolled (24% high-risk). Baseline ≥VGPR responses were 45.5- 49.8%. PFS at 38 months was similar. For < VGPR, 38-mos PFS with TAM:55.8% (95%CI: 45.8%, 64.7%); ACM: 54.0% (44.7%, 62.5%); AM: 50.1% (40.6%, 58.9%); For ≥VGPR, 38-mos PFS with TAM: 57.1% (46.8%, 66.1%); ACM: 60.1% (50.1%, 68.7%); AM: 55.1% (45.1%, 64.0%). Analyzing response, risk category, and Rx revealed no association between baseline response and PFS (Baseline response < VGPR, hazard ratio (HR): 1.21,95% CI: 0.97-1.52) or OS (baseline response < VGPR, HR 1.02, 95%CI:0.70-1.48). High risk category had an adverse association for PFS (HR 1.62, 95% CI: 1.27-2.07) and OS (HR 1.51 (95% CI:1.01-2.26). Conclusions: In this analysis < VGPR at baseline was not associated with PFS or OS. High-risk had an adverse association. Whether accomplishment of CR/minimal residual disease after AM, ACM,or TAM predicts for longer PFS and OS is the subject of ongoing analysis. Clinical trial information: NCT01109004.
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Burma, Joel S., Courtney M. Kennedy, Linden C. Penner, Lauren N. Miutz, Olivia A. Galea, Philip N. Ainslie, and Jonathan D. Smirl. "Long-term heart transplant recipients: heart rate-related effects on augmented transfer function coherence during repeated squat-stand maneuvers in males." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 321, no. 6 (December 1, 2021): R925—R937. http://dx.doi.org/10.1152/ajpregu.00177.2021.
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Previous research has highlighted that squat-stand maneuvers (SSMs) augment coherence values within the cerebral pressure-flow relationship to ∼0.99. However, it is not fully elucidated if mean arterial pressure (MAP) leads to this physiological entrainment independently, or if heart rate (HR) and/or the partial pressure of carbon dioxide (Pco2) also have contributing influences. A 2:1 control-to-case model was used in the present investigation [participant number ( n) = 40; n = 16 age-matched (AM); n = 16 donor control (DM); n = 8 heart transplant recipients (HTRs)]. The latter group was used to mechanistically isolate the extent to which HR influences the cerebral pressure-flow relationship. Participants completed 5 min of squat-stand maneuvers at 0.05 Hz (10 s) and 0.10 Hz (5 s). Linear transfer function analysis (TFA) examined the relationship between different physiological inputs (i.e., MAP, HR, and Pco2) and output [cerebral blood velocity (CBV)] during SSM; and cardiac baroreceptor sensitivity (BRS). Compared with DM, cardiac BRS was reduced in AM ( P < 0.001), which was further reduced in HTR ( P < 0.045). In addition, during the SSM, HR was elevated in HTR compared with both control groups ( P < 0.001), but all groups had near-maximal coherence metrics ≥0.98 at 0.05 Hz and ≥0.99 at 0.10 Hz ( P ≥ 0.399). In contrast, the mean HR-CBV/Pco2-CBV relationships ranged from 0.38 (HTR) to 0.81 (DM). Despite near abolishment of BRS and blunted HR following heart transplantation, long-term HTR exhibited near-maximal coherence within the MAP-CBV relationship, comparable with AM and DM. Therefore, these results show that the augmented coherence with SSM is driven by blood pressure, whereas elevations in TFA coherence as a result of HR contribution are likely correlational in nature.
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Haddad, Philip, Furqan Akhtar, and Kevin Gallagher. "RADT-37. THE IMPACT OF POSTOPERATIVE RADIATION THERAPY (PORT) AND EXTENT OF SURGERY ON CLINICAL OUTCOMES OF ATYPICAL MENINGIOMA (AM): A META-ANALYSIS." Neuro-Oncology 22, Supplement_2 (November 2020): ii189. http://dx.doi.org/10.1093/neuonc/noaa215.790.
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Abstract BACKGROUND Although meningiomas are among the most prevalent types of brain tumors, AMs account for around 4% of all meningiomas. AMs tend to be more aggressive with relatively higher rates of recurrence and mortality. Gross total resection (GTR) has been the standard of care when possible. However, GTR itself is not always enough to prevent the recurrence of AMs. The role of PORT remains controversial in AM as the comparative studies to support its use have provided conflicting RESULTS: The purpose of this meta-analysis is to evaluate the impact of PORT on clinical outcomes according to the extent of resection in AMs. METHODS A review of the medical literature was conducted using online databases. Inclusion criteria consisted of AM diagnosis, English language, Simpson graded resections, and comparative studies reporting recurrence rates (RcR), Progression-Free Survival (PFS), and Overall Survival (OS) with hazard ratios (HR) or Kaplan-Meier curves. A meta-analysis was conducted using an inverse variance method with a random-effects model. RESULTS Twenty-two comparative studies with a total of 5,129 patients were included and analyzed. When GTR was attained, PORT was associated with improved RcR (HR =0.72, 95%CI:0.59-0.86) and PFS (HR=0.77, 95%CI:0.65-0.90), but not OS (HR=0.93, 95%CI:0.83-1.04). When subtotal resection (STR) was attained, PORT was associated with improved PFS (HR=0.35, 95%CI:0.26-0.48) as well as OS (HR=0.70, 95%CI:0.54-0.89). The extent of surgery also impacted AM outcomes as GTR demonstrated superior PFS (HR=0.45, 95%CI:0.31-0.65) and OS (HR=0.30, 95%CI:0.13-0.72). CONCLUSIONS This is the first meta-analysis to show that PORT is associated with PFS benefit in AMs with GTR and STR. Moreover, PORT significantly improved OS of AMs that underwent STR but had no impact on OS when GTR was achieved. In the absence of randomized clinical trials, this meta-analysis represents the most compelling data supporting the use of PORT in this patient population.
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Kim, Ki-Hun, Juhui Lee, Chang Ho Ahn, Hyeong Won Yu, June Young Choi, Ho-Young Lee, Won Woo Lee, and Jae Hoon Moon. "Association between Thyroid Function and Heart Rate Monitored by Wearable Devices in Patients with Hypothyroidism." Endocrinology and Metabolism 36, no. 5 (October 31, 2021): 1121–30. http://dx.doi.org/10.3803/enm.2021.1216.
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Background: Heart rate (HR) monitored by a wearable device (WD) has demonstrated its clinical feasibility for thyrotoxicosis subjects. However, the association of HR monitored by wearables with hypothyroidism has not been examined. We assessed the association between serum thyroid hormone concentration and three WD-HR parameters in hypothyroid subjects.Methods: Forty-four subjects scheduled for radioactive iodine therapy (RAI Tx) after thyroid cancer surgery were included. Thirty subjects were prepared for RAI Tx by thyroid hormone withdrawal (hypothyroidism group) and 14 subjects by recombinant human thyrotropin (control group). Three WD-HR parameters were calculated from the HR data collected during rest, during sleep, and from 2:00 AM to 6:00 AM, respectively. We analyzed the changes in conventionally measured resting HR (On-site rHR) and WDHR parameters relative to thyroid hormone levels.Results: Serum free thyroxine (T4) levels, On-site rHR, and WD-HR parameters were lower in the hypothyroid group than in the control group at the time of RAI Tx. WD-HR parameters also reflected minute changes in free T4 levels. A decrease in On-site rHR and WD-HR parameters by one standard deviation (On-site rHR, approximately 12 bpm; WD-HR parameters, approximately 8 bpm) was associated with a 0.2 ng/dL decrease in free T4 levels (P<0.01) and a 2-fold increase of the odds ratio of hypothyroidism (P<0.01). WD-HR parameters displayed a better goodness-of-fit measure (lower quasi-information criterion value) than On-site rHR in predicting the hypothyroidism.Conclusion: This study identified WD-HR parameters as informative and easy-to-measure biomarkers to predict hypothyroidism.
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Herrinton, Lisa J., Liyan Liu, Robert Goldfien, M. Alex Michaels, and Trung N. Tran. "Risk of Serious Infection for Patients with Systemic Lupus Erythematosus Starting Glucocorticoids with or without Antimalarials." Journal of Rheumatology 43, no. 8 (July 1, 2016): 1503–9. http://dx.doi.org/10.3899/jrheum.150671.
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Objective.To compare serious infection risk for systemic lupus erythematosus (SLE) patients starting glucocorticoids (GC), antimalarials (AM), or their combination.Methods.We conducted a new-user, historical cohort study, Kaiser Permanente Northern California, 1997–2013. Cox proportional hazards analysis was used to calculate adjusted HR and 95% CI.Results.The study included 3030 patients with SLE followed an average of 4 years. Compared with patients starting AM without GC (9 infections/1461 patient-yrs), the HR for the risk of infection was 3.9 (95% CI 1.7–9.2) for those starting GC ≤ 15 mg/day without AM (14 infections/252 patient-yrs), while it was 0.0 (0 infections/128 patient-yrs) for those starting the combination. We split the 14 patients with a serious infection and with GC < 15 mg/day into 2 groups: < 7.5 and ≥ 7.5–15 mg/day. The HR for < 7.5 mg/day was 4.6 (95% CI 1.8–11.4) and for ≥ 7.5–15 mg/day, 3.1 (95% CI 1.0–9.7). For patients starting GC > 15 mg/day (reflecting more severe SLE), the risk of infection was nearly the same for the combination of GC and AM (9 infections/135 patient-yrs) and GC alone (41 infections/460 patient-yrs), but the combination users had evidence of more severe disease. Patients with SLE had a 6- to 7-fold greater risk of serious infection than the general population.Conclusion.Our findings suggest that the benefits of AM treatment for SLE may extend to preventing serious infections. Although the study included > 3000 patients, the statistical power to examine GC dosages < 15 mg/day was poor.
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Gallagher, Kevin M., furqan akhtar, and Philip A. Haddad. "Postoperative radiation therapy (PORT) impact on clinical outcomes of resected atypical meningioma: A meta-analysis." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 2570. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.2570.
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2570 Background: Although meningiomas are among the most prevalent types of brain tumors, atypical meningiomas (AM) account for around 4% of all meningiomas. AMs tend to be more aggressive with relatively higher rates of recurrence and mortality. Gross total resection (GTR) has been the standard of care when possible. However, GTR itself is not always enough to prevent recurrence of AMs. The role of PORT remains controversial in AM as the comparative studies to support its use have provided conflicting results. The purpose of this meta-analysis is to evaluate the impact of PORT on clinical outcomes in resected AMs. Methods: A review of the medical literature was conducted using online databases. Inclusion criteria consisted of (i) AM diagnosis, (ii) English language, (iii) Simpson graded resections, and (iv) comparative studies reporting recurrence rates (RcR), Progression Free Survival (PFS), and Overall Survival (OS) with hazard ratios (HR) or Kaplan-Meier curves. A meta-analysis was conducted using an inverse variance method with random-effects model. Results: Twenty-two comparative studies with a total of 5,129 patients were included and analyzed. When GTR was attained, PORT was associated with improved RcR (HR = 0.72, 95%CI:0.59-0.86) and PFS (HR = 0.77, 95%CI:0.65-0.90), but not OS (HR = 0.93, 95%CI:0.83-1.04). When subtotal resection (STR) was attained, PORT was associated with improved PFS (HR = 0.35, 95%CI:0.26-0.48) as well as OS (HR = 0.70, 95%CI:0.54-0.89). Conclusions: This is the first meta-analysis to show that PORT is associated with PFS benefit in AMs with GTR and STR. Moreover, PORT significantly improved OS of AMs that underwent STR but had no impact on OS when GTR was achieved. In the absence of randomized clinical trials, this meta-analysis represents the most compelling data supporting the use of PORT in this patient population.
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Huang, Rong, Gaigai Shen, Yu Ren, Kelin Zheng, Jiayu Wang, Yan Shi, Jiani C. Yin, et al. "Abstract 1358: Prognostic value of genetic aberrations and tumor immune microenvironment in primary acral melanoma." Cancer Research 83, no. 7_Supplement (April 4, 2023): 1358. http://dx.doi.org/10.1158/1538-7445.am2023-1358.
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Abstract Purpose: Acral melanoma (AM) is the most common subtype in Chinese melanoma patients with a very poor prognosis. However, our understanding of the disease pathogenesis and molecular landscape is limited by the few studies that have been conducted. Here, we profiled the clinical characteristics, mutational landscapes and tumor immune microenvironment (TIME) of AM patients to gain insights into disease prognosis and potential treatment strategies. Methods: Tissue samples from 90 AM patients were subjected to next-generation sequencing (NGS) and multiplexed immunohistochemistry (mIHC) tests. The prognostic potential of various mutational features and immune cell compositions were analyzed. Results: The majority of patients presented with stage II (45.6%) and stage III (38.9%) disease. The most common histological subtype was acral lentiginous melanoma (ALM, 44.4%), followed by nodular melanoma (NM, 33.3%) and superficial spreading melanoma (SSM, 11.1%). None of the patients had received anti-tumor treatment prior to surgery and 73.3% received treatments following surgery, including interferon, interferon combined with other drugs, chemotherapy, and anti-PD-1 therapy. The median disease-free survival (mDFS) was 21.3 months and median overall survival (mOS) was 60 months. More advanced stage and histological subtypes of NM and ALM were associated with worse prognosis in AM patients (HR=2.74, 95% CI=1.34-5.60, p = 0.01; HR=5.16, 95% CI=1.51-17.63, p = 0.01, respectively), while patients who received post-surgical treatments had better survival (HR=0.31, 95% CI=0.15-0.63, p<0.01). The most frequently altered genes included BRAF (14.5%), KIT (16.9%), NRAS (12%), NF1 (10.8%), APC (7.2%), and ARID2 (6%). Copy number variations (CNV) were commonly found in CCND1 (19.3%), CDK4 (19.3%), MDM2 (14.5%) and FGF19 (12%). CDK4 amplifications (HR=4.85, 95% Cl=1.72-13.70, p<0.01) and PTPN11 mutations (HR=5.73, 95% Cl=1.44-22.80, p = 0.01) were associated with shorter OS in AM patients. Patients with higher levels of M1 macrophage infiltration in the invasive margin derived markedly longer OS (HR=0.34, 95% CI=0.15-0.77, p = 0.01). Interestingly, in CDK4-amplified patients, there tended to be a low level of M1 macrophage infiltration in the invasive margin ( p = 0.06), which likely explains the poor prognosis in such patients. Conclusions: Our study provided a comprehensive portrait of the clinicopathological features, genetic aberrations and TIME profiles in AM patients and identified candidate prognostic factors. KeywordsAcral melanoma; tumor immune microenvironment; CDK4; M1 macrophages; prognostic factors Citation Format: Rong Huang, Gaigai Shen, Yu Ren, Kelin Zheng, Jiayu Wang, Yan Shi, Jiani C. Yin, Lanqun Qin, Guiying Zhang, Mengke Zhao, Xinyu Su, Luqiao Li, Fufeng Wang, Haimeng Tang, Yang Shao, Baorui Liu, Zhengyun Zou. Prognostic value of genetic aberrations and tumor immune microenvironment in primary acral melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1358.
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Forney, Charles F., and Rodney K. Austin. "Time of Day at Harvest Influences Carbohydrate Concentration in Crisphead Lettuce and Its Sensitivity to High CO2 Levels after Harvest." Journal of the American Society for Horticultural Science 113, no. 4 (July 1988): 581–83. http://dx.doi.org/10.21273/jashs.113.4.581.
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Abstract Concentrations of starch and sugars were measured in the cap leaf (leaf no. 1) and in every fifth leaf (5, 10, 15, 20) in heads of crisphead lettuce (Lactuca sativa L.) harvested at 0700 hr (AM) or 1400 hr (PM) PDT. Starch content increased in the cap leaf from the AM to the PM harvest, but remained unchanged in other leaves. Sucrose concentration was <5 mg·g−1 dry weight in AM-harvested lettuce, but the cap leaf, leaf 20, and stem tissue contained 43, 24, and 61 mg·g−1 dry weight, respectively, in lettuce from the PM harvest. AM harvested lettuce contained 70% to 260% more glucose and 20% to 120% more fructose than PM-harvested lettuce. Glucose and fructose concentrations were greatest in leaf 10 (110 and 120 mg·g−1 dry weight, respectively) and decreased 20% to 50% in inner and outer leaves. Exposure of lettuce to 7.5% or 10% CO2 for 12 days at 2.5°C followed by air for 3 days at 10° caused more severe injury on AM- than on PM-harvested lettuce. Injury occurred primarily on leaves 7 through 17, with those between leaves 10 and 15 being most severely affected. High reducing sugar content at harvest did not appear to decrease the sensitivity of lettuce to high CO2 during storage.
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Carskadon, Mary, Caroline Gredvig-Ardito, David H. Barker, Cosette Coston, and John McGeary. "0166 Effects of Evening Pre-Sleep Alcohol on Next-Day Psychomotor Vigilance (PVT) Performance." SLEEP 46, Supplement_1 (May 1, 2023): A74. http://dx.doi.org/10.1093/sleep/zsad077.0166.
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Abstract Introduction Few reports have examined how pre-sleep alcohol affects performance on the next day given adequate sleep opportunity on a preferred schedule. Our goal is to identify whether alcohol intake targeting .08g% 1 hr before sleep of ~8 h will affect PVT performance on subsequent days, with the hypothesis that morning performance will be negatively affected. Methods 25 adults (13F; age range 22-57 y) completed the full study, including at-home sleep on a fixed schedule of 8-9 hr and two 3-night in-lab PSG sessions spaced ≥3 days apart. Sessions were counterbalanced for alcoholic or nonalcoholic control beverage administered in 3 drinks over 45 minutes ending 1 hr before bedtime. Alcohol was targeted to .08g%. The 10-min PVT (Ambulatory Monitoring, Inc.) was given each night (PM-Lab) 1.5 hr before drinking and in the morning after a light breakfast (AM-Lab) 50 min after waking. PVT was performed at home/work twice each day within 1.5-h windows starting 3h after waking (AM-Home) and 7.5h after waking (PM-Home). Two reaction time (RT) variables were assessed: RRT (1/RT), FRT (10% fastest RT). Linear mixed effects models were used to account for nesting of assessments within alcohol/control condition and days. Results RRTs showed slowed RT (meanRT±SE) following alcohol: AM-Lab F=7.234, p=.008, alcohol RT=246±9.6 msec, control RT=234±9.6 msec; AM-Home F=17.936, p<.001, alcohol RT=254±9.5 msec, control RT=242±9.6 msec; but not PM-Home or PM-Lab tests. FRT slowed for AM-Lab F=9.391, p=.003, alcohol FRT=195±4.3 msec, control FRT=201±4.3 msec; AM-Home F=17.251, p=.001, alcohol FRT= 202±4.4 msec, control FRT=194±4.4 msec; PM-Home F=3.379, p=.068 (trend), alcohol FR=200±4.8 msec, control FRT=196±4.8 msec, but not for PM-Lab PVTs. PM-Home FRT also had a significant day order effect: F=3.087, p=.0496, Day 1 FRT=197±5.0 msec, Day 2 FRT=202±5.0 msec, Day 3 FRT=195±5.0 msec. Conclusion We found statistically significant slowing of psychomotor vigilance RT on days after pre-sleep alcohol lasting up to 3-4.5h after waking in the morning (with a trend up to 7.5-9h post waking). PVT lapses (not shown) were similarly affected by alcohol. Thus, even with sufficient sleep opportunity, RT is impaired following 3 consecutive nights of alcohol drinking. Support (if any) R01AA025593
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Monier, R., M. Gebran, F. Royer, T. Kilicoglu, and Y. Frémat. "HR 8844: A New Transition Object between the Am Stars and the HgMn Stars?" Astrophysical Journal 854, no. 1 (February 9, 2018): 50. http://dx.doi.org/10.3847/1538-4357/aaa246.
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Tompkins, Connie L., Timothy Flanagan, John Lavoie, and David W. Brock. "Heart Rate and Perceived Exertion in Healthy Weight and Obese Children During a Self-Selected Physical Activity Program." Journal of Physical Activity and Health 12, no. 7 (July 2015): 976–81. http://dx.doi.org/10.1123/jpah.2013-0374.
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Background:Compared with structured/organized activities, unstructured, self-selected physical activity (PA) may be more appealing for children in particular obese (OB) children. We examined whether both healthy-weight (HW) and OB children would engage in moderate to vigorous intensity PA during an unstructured PA program and compared heart rate (HR) and rate of perceived exertion (RPE) between the children.Methods:Twenty-one children [9 OB (≥95th BMI percentile, 12 HW (5th – <85th), 8.6 ± 0.8 years; 9 males, 12 females] participated in before-school (7:30 AM to 8:15 AM) PA for 18 weeks, 3 consecutive days/week. Each child wore a Polar E600 HR monitor and was provided a vigorous, age-targeted heart rate (THR) of 70%.Results:Mean HR ≥ vigorous THR for all children in 65.3% of the sessions and exceeded moderate intensity in 100%. Over the 18-weeks, no significant difference was observed in the overall mean HR between the HW (171.4 ± 12.0) and OB (169.3 ± 13.0), however the OB reported significantly lower RPEs than the HW (16.9 ± 2.6 vs. 17.6 ± 1.5, respectively; P < .05).Conclusions:Both the HW and OB children consistently sustained PA of moderate and vigorous intensity. The current study provides insight regarding the physiological capabilities and perceptual responses of HW and OB children participating in PA programs.
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Eder, Lihi, Vinod Chandran, Richard Cook, and Dafna D. Gladman. "The Risk of Developing Diabetes Mellitus in Patients with Psoriatic Arthritis: A Cohort Study." Journal of Rheumatology 44, no. 3 (February 1, 2017): 286–91. http://dx.doi.org/10.3899/jrheum.160861.
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Objective.To estimate the prevalence of diabetes mellitus (DM) in patients with psoriatic arthritis (PsA) in comparison with the general population and to assess whether the level of disease activity over time predicts the development of DM in these patients.Methods.A cohort analysis was conducted in patients followed in a large PsA clinic from 1978 to 2014. The prevalence of DM in the patients was compared with the general population of Ontario, Canada, and the age-standardized prevalence ratio (SPR) was calculated. For the assessment of risk factors for DM, time-weighted arithmetic mean (AM) levels of PsA-related disease activity measures were assessed as predictors for the development of DM. Multivariable Cox proportional hazards models were used to compute HR for incident DM after controlling for potential confounders.Results.A total of 1305 patients were included in the analysis. The SPR of DM in PsA compared with the general population in Ontario was 1.43 (p = 0.002). Of the 1065 patients who were included in the time-to-event analysis, 73 patients were observed to develop DM. Based on multivariable analyses, AM tender joint count (HR 1.53, 95% CI 1.08–2.18, p = 0.02) and AM erythrocyte sedimentation rate (HR 1.21, 95% CI 1.03–1.41, p = 0.02) predicted the development of DM.Conclusion.The prevalence of DM is higher in patients with PsA compared with the general population. Patients with elevated levels of disease activity are at higher risk of developing DM.
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Wan, Zi Yi, Ting Fei Xi, P. Zhao, Cheng Xiang Fan, Y. Sun, and Z. G. Feng. "In Vitro Degradation of Medical Polyacrylamide Hydrogel I.Oxidation." Key Engineering Materials 288-289 (June 2005): 397–400. http://dx.doi.org/10.4028/www.scientific.net/kem.288-289.397.
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Polyacrylamide (PAM) was usually atoxic, stable. Its hydrogel (PAMG) has been used in plastic and aesthetic surgery more than 10 years in P.R.China, Ukraine and Russia. But there were some complications with PAMG injected in patients. Considering the complicacy in vivo, it was necessary to study the PAMG’s stability. In this paper, H2O2 was added in PAMG in vitro and acrylamide (AM) content after oxidating was determined using HPLC method. Detection limit for AM can be achieved in the parts-per-billion rang. The AM content in supernatant at 0.5, 1,2 and 3 hr after oxidating of PAMG was 1.27e-8g/ml, 1.35e-8g/ml, 1.03e-7g/ml and 2.74e-7g/ml, respectively. The AM content in supernatant of PAMG was 7.70e-9g/ml. These results indicated that PAMG can be degraded to AM by hydroxyl radical. Under the same condition, the AM content was stable. So, AM can exist for a while when it was produce by degrading of PAMG. That can increase the toxicity of PAMG.
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Black, C. M., J. R. Catterall, and J. S. Remington. "In vivo and in vitro activation of alveolar macrophages by recombinant interferon-gamma." Journal of Immunology 138, no. 2 (January 15, 1987): 491–95. http://dx.doi.org/10.4049/jimmunol.138.2.491.
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Abstract In vivo administration of recombinant interferon-gamma (rIFN-gamma) was previously shown to result in activation of the microbicidal activities of peritoneal macrophages (PM phi). Because macrophages at different anatomical sites vary in their functional capacities, we considered it of interest to determine whether administration of murine rIFN-gamma, either in vitro or in vivo, can enhance the microbicidal activity of resident alveolar macrophages (AM phi) and to compare the effects of rIFN-gamma on AM phi and PM phi. After incubation in vitro with rIFN-gamma, the antimicrobial activities of both murine AM phi and PM phi were enhanced, as assessed by their ability to inhibit replication of the intracellular parasite, Toxoplasma gondii. This effect was dose dependent for AM phi over a range of 0.1 to 1 U/ml and for PM phi over a range of 0.5 to 1000 U/ml. In this assay, the minimum dosage required for in vitro activation of AM phi was one-half that required for activation of PM phi, suggesting a greater sensitivity of AM phi to the in vitro activity of rIFN-gamma. Macrophages from both anatomical sites were also activated when rIFN-gamma was administered in vivo. This effect was dose dependent over a range of 10(3) to 10(5) U/mouse. Freshly harvested AM phi and PM phi from mice injected 24 hr earlier with 10(4) U rIFN-gamma by either the i.v. or i.p. routes markedly inhibited intracellular multiplication of Toxoplasma. In contrast, AM phi and PM phi from control mice permitted fourfold to ninefold increases in numbers of intracellular Toxoplasma. The anti-toxoplasma activity of AM phi and PM phi gradually diminished over a period of 3 days when assayed at successive 24 hr periods after a single i.v. injection of rIFN-gamma. At 3 days after injection, a substantial loss of anti-toxoplasma activity was observed with PM phi as compared with controls; residual anti-toxoplasma activity was still demonstrable in AM phi at 3 days. These results demonstrate that in vitro as well as in vivo treatment with rIFN-gamma confers on AM phi an enhanced antimicrobial activity. These findings provide a rationale for evaluating rIFN-gamma in the treatment of pulmonary infections, especially those due to opportunistic pathogens against which AM phi play a major role in host defense.
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Overdahl, Kirsten E., Rebecca Sutton, Jennifer Sun, Noelle J. DeStefano, Gordon J. Getzinger, and P. Lee Ferguson. "Assessment of emerging polar organic pollutants linked to contaminant pathways within an urban estuary using non-targeted analysis." Environmental Science: Processes & Impacts 23, no. 3 (2021): 429–45. http://dx.doi.org/10.1039/d0em00463d.
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Non-targeted analysis of polar organic pollutants using high resolution/accurate mass (HR/AM) mass spectrometry has been conducted in waters of San Francisco (SF) Bay to assess occurrence of emerging contaminants and inform future monitoring and management activities.
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Kumar, Ranjeet, and Mahendra Singh. "Effect of arbuscular mycorrhizal (AM) fungi inoculation on enzymatic activity and zinc uptake under direct seeded rice system." Journal of Applied and Natural Science 9, no. 2 (June 1, 2017): 1157–63. http://dx.doi.org/10.31018/jans.v9i2.1340.
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The application of treatment T3 (Glomus mosseae + 100 % RDF NK) produced significantly more root volume by 72.60 %, 17.80 %, 12.25 %, 14.13 % over the application of treatment T1 (Control), treatment T5 (Glomus coronatum+ 100 % RDF NK), T6 (Gigasporadecipein + 100 % RDF NK) and T7 (BAU AM-1(Glomus sp + 100 % RDF NK), respectively. Similar trend shows at harvesting stage, here the maximum root volume (23c.c) was recorded by the application of T3 (Glomus mosseae + 100 % RDF NK). Maximum AM colonization and spore count was observed at panicle initiation stage with the application of treatment T3 (Glomus mosseae + 100 % RDF NK). This treatment also gave maximum dehydrogenase activity (55.86 µg TPF g-1 24 hr-1), acid phosphatase activity (0.299 mg PNP g-1 hr-1) and alkaline phosphatase activity (0.54 mg PNP g-1 hr-1) at panicle initiation stage. Application of treatment T3 (Glomus mosseae + 100 % RDF NK) significantly increased DTPA extractable Zn in soil and Zn content in plant when compared with all the treatments except treatment T6 (Gigasporadecipien+ 100 % RDF NK). The maximum zinc uptake (0.056 mg pot-1) by grain was recorded under treatment T3 (Glomus mosseae + 100 % RDF NK) followed by application of treatment T6 (Gigasporadecipien + 100 % N and K). Highest grain yield (14.08 g pot-1) was found with the treatment T3 (Glomus mosseae + 100 % RDF NK). As evident from the results, the AM fungal inoculation can effectively modify the soil microbe population and community structure by increasing the soil enzymatic activities and significantly increased the zinc uptake by grain in direct seeded rice (DSR).
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Rodríguez, E., and M. Breger. "δ Scuti Variables in the HR Diagram." International Astronomical Union Colloquium 185 (2002): 322–23. http://dx.doi.org/10.1017/s0252921100016341.
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The location of the δ Scuti variables in the HR diagram is discussed on the basis of HIPPARCOS parallaxes and uvbyβ photometry together with the R00 catalogue (Rodríguez et al., 2000). In particular, the properties of the α Scuti-type pulsators with nonsolar surface abundances (SX Phe, λ Boo, ρ Pup, δ Del and classical Am stars subgroups) are examined.The latter four classes of stars are spectroscopically defined subclasses with surface abundance anomalies. Although the stars ρ Pup and δ Del are also pulsators, the groups named after these stars should not be regarded as pulsation subclasses of δ Scuti stars. The abundance anomalies in these stars affect the pulsation properties, e.g., the classical Am stars are constant in light or show only small pulsation amplitudes (e.g., HD 1097). These four groups are only a small selection from the bewildering zoo of stars with unusual surface abundances in this temperature region and represent the groups with δ Scuti pulsation.
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Bathina, Chandra Sekhar, Anuradha Rajulapati, Michelle Franzke, Kenta Yamamoto, J. Thomas Cunningham, and Steve Mifflin. "Knockdown of tyrosine hydroxylase in the nucleus of the solitary tract reduces elevated blood pressure during chronic intermittent hypoxia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 305, no. 9 (November 1, 2013): R1031—R1039. http://dx.doi.org/10.1152/ajpregu.00260.2013.
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Noradrenergic A2 neurons in nucleus tractus solitarius (NTS) respond to stressors such as hypoxia. We hypothesize that tyrosine hydroxylase (TH) knockdown in NTS reduces cardiovascular responses to chronic intermittent hypoxia (CIH), a model of the arterial hypoxemia observed during sleep apnea in humans. Adult male Sprague-Dawley rats were implanted with radiotelemetry transmitters and adeno-associated viral constructs with green fluorescent protein (GFP) reporter having either short hairpin RNA (shRNA) for TH or scrambled virus (scRNA) were injected into caudal NTS. Virus-injected rats were exposed to 7 days of CIH (alternating periods of 10% O2 and of 21% O2 from 8 AM to 4 PM; from 4 PM to 8 AM rats were exposed to 21% O2). CIH increased mean arterial pressure (MAP) and heart rate (HR) during the day in both the scRNA ( n = 14, P < 0.001 MAP and HR) and shRNA ( n = 13, P < 0.001 MAP and HR) groups. During the night, MAP and HR remained elevated in the scRNA rats ( P < 0.001 MAP and HR) but not in the shRNA group. TH immunoreactivity and protein were reduced in the shRNA group. FosB/ΔFosB immunoreactivity was decreased in paraventricular nucleus (PVN) of shRNA group ( P < 0.001). However, the shRNA group did not show any change in the FosB/ΔFosB immunoreactivity in the rostral ventrolateral medulla. Exposure to CIH increased MAP which persisted beyond the period of exposure to CIH. Knockdown of TH in the NTS reduced this CIH-induced persistent increase in MAP and reduced the transcriptional activation of PVN. This indicates that NTS A2 neurons play a role in the cardiovascular responses to CIH.
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SOOD, SURABHI, MOHIT KUMAR, RAM BILAS PACHORI, and U. RAJENDRA ACHARYA. "APPLICATION OF EMPIRICAL MODE DECOMPOSITION–BASED FEATURES FOR ANALYSIS OF NORMAL AND CAD HEART RATE SIGNALS." Journal of Mechanics in Medicine and Biology 16, no. 01 (February 2016): 1640002. http://dx.doi.org/10.1142/s0219519416400029.
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Coronary Artery Disease (CAD) is a heart disease caused due to insufficient supply of nutrients and oxygen to the heart muscles. Hence, reduced supply of nutrients and oxygen causes heart attack or stroke and may cause death. Also significant number of people are suffering from CAD around the world so timely diagnosis of CAD can save the life of patients. In this work, we have proposed computer assisted diagnosis of CAD using Heart Rate (HR) signals obtained from Electrocardiogram (ECG) signals. We have used the Empirical Mode Decomposition (EMD) technique to process the HR signals. The features namely: Second-Order Difference Plot (SODP) area, Analytic Signal Representation (ASR) area, Amplitude Modulation (AM) bandwidth, Frequency Modulation (FM) bandwidth and Fourier–Bessel expansion (FBE)- based mean frequency computed from the Intrinsic Mode Functions (IMFs) are extracted to discriminate normal and CAD subjects. Thereafter, Kruskal–Wallis statistical test is performed on these features. The features having p-value less than 0.05 are considered to be significant. Our results show that three features namely: AM bandwidth, FM bandwidth and FBE-based mean frequency are more suitable than ASR area and SODP area features for discrimination of normal and CAD subjects.
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Costa, Camila Q. V., Inês I. Afonso, Sandra Lage, Pedro Reis Costa, Adelino V. M. Canário, and José P. Da Silva. "Quantitation Overcoming Matrix Effects of Lipophilic Toxins in Mytilus galloprovincialis by Liquid Chromatography-Full Scan High Resolution Mass Spectrometry Analysis (LC-HR-MS)." Marine Drugs 20, no. 2 (February 15, 2022): 143. http://dx.doi.org/10.3390/md20020143.
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The analysis of marine lipophilic toxins in shellfish products still represents a challenging task due to the complexity and diversity of the sample matrix. Liquid chromatography coupled with mass spectrometry (LC-MS) is the technique of choice for accurate quantitative measurements in complex samples. By combining unambiguous identification with the high selectivity of tandem MS, it provides the required high sensitivity and specificity. However, LC-MS is prone to matrix effects (ME) that need to be evaluated during the development and validation of methods. Furthermore, the large sample-to-sample variability, even between samples of the same species and geographic origin, needs a procedure to evaluate and control ME continuously. Here, we analyzed the toxins okadaic acid (OA), dinophysistoxins (DTX-1 and DTX-2), pectenotoxin (PTX-2), yessotoxin (YTX) and azaspiracid-1 (AZA-1). Samples were mussels (Mytilus galloprovincialis), both fresh and processed, and a toxin-free mussel reference material. We developed an accurate mass-extracted ion chromatogram (AM-XIC) based quantitation method using an Orbitrap instrument, evaluated the ME for different types and extracts of mussel samples, characterized the main compounds co-eluting with the targeted molecules and quantified toxins in samples by following a standard addition method (SAM). An AM-XIC based quantitation of lipophilic toxins in mussel samples using high resolution and accuracy full scan profiles (LC-HR-MS) is a good alternative to multi reaction monitoring (MRM) for instruments with HR capabilities. ME depend on the starting sample matrix and the sample preparation. ME are particularly strong for OA and related toxins, showing values below 50% for fresh mussel samples. Results for other toxins (AZA-1, YTX and PTX-2) are between 75% and 110%. ME in unknown matrices can be evaluated by comparing their full scan LC-HR-MS profiles with those of known samples with known ME. ME can be corrected by following SAM with AM-XIC quantitation if necessary.
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Diana, Bagus Priyo Purwanto, and Afton Atabany. "Pengaruh Ketinggian Tempat Terhadap Respon Termoregulasi Kambing Peranakan Etawah (PE)." Jurnal Sains Terapan 6, no. 1 (June 30, 2016): 52–62. http://dx.doi.org/10.29244/jstsv.6.1.52-62.
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Etawah grade does were kept in different environment. Current research was conducted to compare the thermoregulatory response of Etawah grade goat which were kept at 200, 400 and 600 m asl. Measured environmental factors were temperature (Ta), relative humidity (Rh), and air velocity (Va) were measured for 12 hours from 06.00 am to 06.00 pm. Thermoregulatory response included rectal temperature (Tr), respiration rate (Rr) and heart rate (Hr) were measured every day at 6 am, 12 am and 6 pm. Data obtained were analyzed statistically using independent two-sample T-Test and regression analysis. The results showed different altitude 200, 400 and 600 m asl significantly affected (P<0.05) ambient temperature, which were average 30,16±2,88; 27,73±2,45 and 26,63±2,91; respectively. Otherwise, different altitude did not affect humidity and air velocity. Altitude significantly affected (P<0.05) rectal temperature and heart rate, but did not affect respiration rate. Etawah grade goat were comfortable to kept in 400 m asl.
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Menon, G., R. Sloboda, S. Ghosh, G. Dundas, R. Pearcey, and F. Huang. "Sci-Sat AM: Brachy - 08: MRI-guided planning and maximum achievable HR-CTV doses in cervix brachytherapy." Medical Physics 39, no. 7Part4 (July 2012): 4646. http://dx.doi.org/10.1118/1.4740215.
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Anigbogu, Chikodi N., Daniel T. Williams, David R. Brown, Dennis L. Silcox, Richard O. Speakman, Laura C. Brown, Dennis G. Karounos, and David C. Randall. "Circadian Variations in Blood Pressure, Heart Rate, and HR-BP Cross-Correlation Coefficient during Progression of Diabetes Mellitus in Rat." International Journal of Hypertension 2011 (2011): 1–8. http://dx.doi.org/10.4061/2011/738689.
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Circadian changes in cardiovascular function during the progression of diabetes mellitus in the diabetes prone rat (BBDP) (n=8) were studied. Age-matched diabetes-resistant rats (BBDR) served as controls. BP was recorded via telemetry in contiguous 4 hr time periods over 24 hours starting with 12 midnight to 4 am as period zero (P0). Prior to onset of diabetes BP was high at P0, peaked at P2, and then fell again at P3; BP and heart rate (HR) then increased gradually at P4 and leveled off at P5, thereby exhibiting a bipodal rhythm. These patterns changed during long-term diabetes. The cross-correlation coefficient of BP and HR was not significantly different across groups at onset, but it fell significantly at 9 months of duration of diabetes (BBDP: 0.39 ± 0.06; BBDR: 0.65 ± 0.03;P<.05). These results show that changes in circadian cardiovascular rhythms in diabetes mellitus became significant at the late stage of the disease.
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Nagarajan, Priyadharsini, JIn Piao, Jing Ning, Laura E. Noordenbos, Jonathan L. Curry, Carlos A. Torres-Cabala, A. Hafeez Diwan, et al. "Abstract A11: Prognostic model for disease-specific survival in anorectal melanoma." Cancer Research 80, no. 19_Supplement (October 1, 2020): A11. http://dx.doi.org/10.1158/1538-7445.mel2019-a11.
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Abstract Background: Anorectal melanoma (AM) is generally staged using criteria developed and validated for cutaneous melanoma (CM), primarily due to its rarity and the lack of a specific staging system, despite limited evidence to support this. In an attempt to risk-stratify AM patients (pts), we analyzed the performance of the AJCC 8th edition CM staging system and a system recently developed for vulvar melanoma (VM) in a retrospective cohort. Methods: Demographics, clinicopathologic factors, and follow-up information were collected for 160 AM pts treated at our institution. The pts were grouped based on their clinical stage at presentation (localized to anorectum [L], regional metastases [R], distant metastases [D]). For further risk stratification, L pts were grouped according to the following systems: (i) AJCC 8th edition CM T-categories (T1a to T4b, 8 tiers); (ii) AJCC 8th edition CM stage (I vs. II, 2 tiers); (iii) the tumor thickness (TT) system (thin [T1], intermediate [T2-T3], thick [T4], 3 tiers); and TM system previously derived for VM (T1: TT≤ 2.0mm and mitotic rate (MR) <2/mm2 and T2: TT >2.0mm and MR <2/mm2). Univariate (UV) and multivariable (MV) Cox proportional hazards regression modeling determined associations with disease specific survival (DSS). The Kaplan-Meier method estimated overall survival (OS) and DSS. Results: The cohort (n=160) included 67 L, 55 R and 38 D pts. With median follow-up of 1.63 years (y), the median DSS was 1.75y for all pts. DSS progressively decreased according to stage at presentation (L: 2.39y; R: 1.81y and D: 1.25y). By UV analysis, clinical stage at presentation correlated with DSS (R: p=0.05, HR=1.52; D: p<0.001, HR=3.24, compared to L). By MV analysis (including clinical stage, tumor thickness, regression [REG], lymphovascular invasion [LVI], perineural invasion and resection margin status), the presence of distant metastasis correlated with DSS (p<0.001, HR=2.71), in addition to tumor thickness, REG, and LVI. To further optimize risk modeling and clinical management, we analyzed L pts using 4 distinct T-categorization systems. The 3-tier TT system robustly stratified DSS (p=0.03; HR- intermediate=2.36, thick=4.98, compared to thin). AJCC stage also classified 2 groups of pts according to DSS, with a trend towards significance (p=0.1; HR=3.37). In contrast, only OS models could be derived for the AJCC 8th edition T-categories (p=0.14) and TM system (p=0.1), with the latter yielding clear differences in outcomes, compared to the former. Analysis was also performed on a combined cohort of L pts with VM and AM, to determine if there are unifying themes among anogenital mucosal melanomas, and all the 4 systems stratified the pts (p<0.001), with stage, TT, and TM systems yielding clear differences in outcomes, compared to the 8 AJCC T-categories. Conclusion: Clinical stage at presentation and T-categorization of L pts based on modifications of the 8th edition AJCC CM staging criteria (stage and TT system) appear to be potentially informative tools to stratify risk in AM pts. Citation Format: Priyadharsini Nagarajan, JIn Piao, Jing Ning, Laura E. Noordenbos, Jonathan L. Curry, Carlos A. Torres-Cabala, A. Hafeez Diwan, Phyu P. Aung, Doina Ivan, Merrick I. Ross, Richard E. Royal, Jennifer A. Wargo, Wei-Lien Wang, Rashmi Samdani, Alexander J. Lazar, Asif Rashid, Michael A. Davies, Victor G. Prieto, Jeffrey E. Gershenwald, Michael T. Tetzlaff. Prognostic model for disease-specific survival in anorectal melanoma [abstract]. In: Proceedings of the AACR Special Conference on Melanoma: From Biology to Target; 2019 Jan 15-18; Houston, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(19 Suppl):Abstract nr A11.
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Shi, Patricia A., Luis M. Isola, and Lorraine Miller. "Prospective Study Of Mobilization Kinetics Up To 18 Hours After Late Afternoon Dosing Of Plerixafor." Blood 122, no. 21 (November 15, 2013): 4510. http://dx.doi.org/10.1182/blood.v122.21.4510.4510.
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Background Plerixafor (Mozobil®, Genzyme, Cambridge, MA) is approved for hematopoietic progenitor cell (HPC) mobilization into peripheral blood (PB) in combination with granulocyte colony stimulating factor (G-CSF) at ∼11 hours (hr) prior to apheresis initiation. Since apheresis facilities typically open at 8-9 AM, this 11 hr interval requires plerixafor dosing between 9-10 pm, impractical unless the patient self-administers the drug. No studies have examined mobilization kinetics beyond 15 hr in the target MM and NHL patient population. This is the first study in this target population to examine a total interval time of 17-18 hr post-plerixafor, important because, practically, leukapheresis may not be initiated until 10-11 AM. Even if initiated earlier between 8-9 AM, a standard leukapheresis typically lasts ∼3 hr. Therefore, it is important to rule out a significant decrease in PB [CD34+] extending through this interval. Study Design and Methods A single-center, prospective cohort, IRB-approved study where 11 patients with NHL and MM underwent HPC mobilization from March 2010 to October 2011. Patients met the same entry criteria specified in the initial studies leading to FDA approval. Plerixafor 240 ug/kg was administered at 5pm on day 4 of AM G-CSF 10 ug/kg. PB [CD34+] and [CD34+CD38-] concentrations were enumerated every 2 hours from 5PM to 7AM and immediately pre-apheresis on day 5, for a total interval time of 17-18 hr post-plerixafor. Leukapheresis (3 total blood volumes) was performed if the 7 am peripheral blood CD34+ concentration was ≥10/uL. Data was analyzed used mixed model analysis of repeated measures. Results 9 of 11 subjects , including all 5 patients who had received 3-9 cycles of lenalidomide, achieved a CD34+ product count of >5x106/kg with a single leukapheresis. All 9 patients (in contrast to the other 2) had a pre-plerixafor PB CD34+ concentration > 10/uL. PB [CD34+] did not differ between 10-18 hours post-plerixafor (p≈0.8). In contrast, PB [CD34+CD38-] increased from 10 to 18 hours post-plerixafor (p=0.03). 10 subjects underwent transplant with a median CD34+ dose of 6.0x106/kg (range 3.8-10.8x 106/kg) and engrafted within normal time frames. Using post- to (5PM) pre-plerixafor [CD34+] ratios to compare efficacy of plerixafor kinetics, the median ratio of the 17-18hr post/pre-plerixafor [CD34+] was 4.0 (range 1.8-6.8), not significantly different (p=0.09) from that of the peak post/pre-plerixafor [CD34+] of 4.7 (range 1.9-9). The 3 subjects with lowest mobilization had diabetes, but the peak post/pre [CD34+] ratio was not adversely affected. Two of these three reached their peak [CD34+] mobilization at 8hr post-plerixafor, whereas all other donors reached their peak [CD34+] ≥ 10hr post-plerixafor. The correlation coefficient of 0.54 between the PB [CD34+] and [CD34+CD38-] was weak. Conclusions In MM and NHL patients with adequate pre-plerixafor CD34+ concentration, which includes those with prior lenalidomide, leukapheresis initiated 17-18 hours post-plerixafor may not impair CD34+ product yield and may increase more primitive CD34+CD38- yield. Patient with risk factors for poor mobilization, such as diabetes or salvage chemotherapy, may be an exception. The three donors with post-plerixafor PB [CD34+] < 100/uL all had diabetes, which has been established to impair G-CSF induced stem cell mobilization. Our data supports murine data that plerixafor overcomes sympathetic nervous system-related defects in mobilization, since the peak post/pre plerixafor [CD34+] ratio was > 4 in all 3 patients. Interestingly, the donor with the second highest mobilization also had diabetes but a low peak/pre [CD34+] ratio of 2.9 (i.e. excellent mobilization with G-CSF alone); her mobilization impairment from diabetes may have been overcome by concurrent use (for asthma) of the β2-adrenergic agonist albuterol, previously associated with high mobilization. Consistent with previous studies, the 2 patients with poor [CD34+] mobilization reached their peak PB [CD34+] < 11 hours post-plerixafor. Finally, given the weak correlation between PB [CD34+] and [CD34+CD38-] , the utility of using PB [CD34+CD38-] to help determine the optimal time for collection may be worth exploring, given the correlation between CD34+CD38- graft content and long-term hematopoietic reconstitution in autologous transplantation. Disclosures: Off Label Use: Plerixafor administered up to 18 hours prior to apheresis initiation, rather than the FDA-approved 11 hours.
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Baykara, M., A. Demirkazik, A. Elhan, B. Yalcin, A. Buyukcelik, M. Dogan, G. Utkan, et al. "Lymphopenia and monocytopenia versus MASCC score system in patients with febrile neutropenia." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 18622. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.18622.
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18622 Background: The purpose of this study was determine the clinical significance of lymphopenia and monocytopenia in terms of its duration and depth in patients with febrile neutropenia (FEN) and MASCC scores parametres. Methods: Sixty-six patients with FEN were prospectively analysed. Recurrent FEN episodes were excluded in this trial. Twenty-four patients had solid tumors, 42 patients had lymphoma-leukemia. Patients with MASCC-scores ≥21 evaluated as low-risk (LR) and the ones with their scores <21 were high-risk (HR). Results: Thirty-six patients had HR and the rest had LR. Lymphocyte count <700/mm3 and monocyte count <100/mm3 were found as 91.6% and 86.6% in HR and in LR groups, respectively.The rate of refractory fever(RF) in HR patients was clearly high.Patients with protracted neutropenia (PN) had higher rate of RF (p = 0.007). Patients with longer duration of neutropenia and monocytopenia tended to have RF (p = 0.052, p = 0.018). The rate of administered AFT was significantly high in HR patients (p = 0.005). AFT was administered to one third of HR patients, but no patient received AFT in LR-group (p < 0.001). In group with neutropenia duration (ND) <10 days, one patient received AFP (p < 0.001). AFT was given to most of the patients who had longer duration of lymphopenia or monocytopenia (respectively; p = 0.002, p = 0.001), and who had leukemia (p = 0.001). The most important parameters effecting the duration of antibiotic therapy (DAT) was found to be ND. DAT >14 days was found more than fourfold in patients PN (p = 0.007). Fifty-five percent out of patients with solid tumor or lymphoma were given <14 days antibiotic therapy. But, most of patients with leukemia had antibiotics >14 days (p = 0.002).The rate of antibiotic therapy >14 days was higher in patients with longer duration of lymphopenia and monocytopenia (respectively; p = 0.073, p = 0.062). The most important parameter that influences on antibiotic modification (AM) was severity of monocytopenia on the first day of FEN. The rate of AM was found in aproximately nine-fold in patients that had monocyte counts ≤100/ mm3 as compared to monocyte ≥100/ mm3 (p = 0.01). Conclusions: The depth of monocytopenia and durations of lymphopenia and monocytopenia were the important parameter influencing antibiotic modification in FEN. No significant financial relationships to disclose.
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Chollet, P. J., P. Dubray, X. Durando, C. Abrial, B. Nayl, M. Mouret-Reynier, C. Pomel, A. Bellière, S. Lemery, and F. Penault-Llorca. "Pathologic complete response (pCR) in HER2 positive breast cancer to sequential FEC 100-docetaxel (D) plus trastuzumab (T) neoadjuvant chemotherapy (NCT)." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e11560-e11560. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11560.
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e11560 Background: Trastuzumab plus chemotherapy has become the standard of care for Her-2-positive breast cancer. Recent trials have shown higher pCR rates in Her2-positive tumors with trastuzumab-driven combinations (Buzdar, JCO 2005; Coudert, Ann Oncol, 2006). The purpose of this study was to review efficacity of sequential FEC followed by D+T. Methods: 21 patients (pts) with Her2-positive breast cancer (defined as either immunohistochemical 3+ or fluorescence in situ hybridization-positive) from June 2006 to September 2008 with breast cancer received 3 cycles (c) of FEC 100 ( epirubicin 100 mg/m2 + 5-fluorouracil and cyclophosphamide 500mg/m2) followed by 3 c of D (100mg/m2) every 3 weeks +T 2mg/kg weekly or 6mg/kg every 3 weeks (9 weeks of T). pCR was defined according to Chevallier's (Am J Clin Oncol, 1993) as level 1 and 2 and to Sataloff's classification (J Am Coll Surg, 1995) as grade A. A clinical, mammography and ultrasound breast evaluation was performed at baseline, after 3 or 4 c and before surgery. Cardiac evaluation (ejection fraction) was performed at baseline, after 3 c of FEC, before surgery and every 3 months after. Results: Median age was 52.1 years [27–71]. Median diameter of the tumors was 45 mm [10–160]. All pts had a ductal carcinoma. 5 pts had inflammatory breast cancer. 1 pts were grade I SBR, 13 grade II SBR, 6 grade III SBR and 1 unspecified. 5 tumors were HR+, 15 HR- and 1 unspecified. After FEC 100 x3, a clinical partial response (PR) was obtained in 4 pts (19%). After completion of NCT,clinical objective response rate was 95.2%: 13 pts had a complete response and 7 pts a partial response. 13 pts (62%) underwent breast-conserving surgery. 10 pts (47.6%) achieved pCR using Chevallier's classification (1 HR+ and 9 HR-) and 12 pts (57.1%) using Sataloff's classification (2 HR+ and 10 HR-). At the time of the analysis for cardiac evaluation, 8 pts continued to receive adjuvant T. 1 pt was lost for follow-up. 5 pts (25%) had an asymptomatic drop of ejection fraction greater than 10%. Conclusions: This regimen with only 9 weeks preoperative trastuzumab resulted in a high rate of pCR in Her2-positive tumors, without clinical cardiac events until now. No significant financial relationships to disclose.
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Parmar, Simrit, Joshua Howell, Michael Wang, Mubeen A. Khan, Qaiser Bashir, Jatin J. Shah, Nina Shah, et al. "High Dose Therapy Improves Survival in Systemic Light Chain Amyloidosis: 14 Year Follow up." Blood 120, no. 21 (November 16, 2012): 750. http://dx.doi.org/10.1182/blood.v120.21.750.750.
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Abstract Abstract 750 Background: Treatment remains a challenge for systemic light chain amyloidosis (AL). Autologous stem cell transplant (AutoSCT) has been associated with long term survival. However, a recent multicenter randomized study failed to show survival benefit for AutoSCT perhaps due to high non-relapse mortality (NRM). Here we present a comparison of AutoSCT to other conventional therapies in AL patients treated at our institution with a 14-year follow up. Methods: A total of 2018 cases were identified upon pathology review from 1998–2012. AL was confirmed in 264 patients; primary amyloidosis (PA) in 147 pts and multiple myeloma with amyloidosis (AM) in 110 patients; solitary amyloidoma in 7 patients. AutoSCT was performed in 126 patients (PA=79 and AM=47). Results: The day 100 NRM was 5% and 1-year NRM was 8%. With a follow up of 14 years in surviving patients, the 10-year overall survival (OS) of AL patients was significantly better in those undergoing AutoSCT (41% vs. 17%; p<0.0001; figure 1). Involvement of more than one organ (6-yr OS 36% vs. 55%; p=0.04) and cardiac involvement (2-yr OS of 57% vs. 78%; p=0.01) were associated with poor outcome. In the patients undergoing AutoSCT: PA vs. AM, Mayo staging, Boston University (BU) staging or bone marrow plasma cells >10 % at the time of autoSCT did not have an impact on OS. Cardiac biomarkers including NT-ProBNP and Troponin-I and T levels were available in a limited number of patients and were not analyzed for survival outcomes. In multivariate analysis, superior OS was associated with: age <60yrs (HR 2.1, p=0.022); and induction treatment before AutoSCT (HR 2.7, p=0.02). Involvement of kidney as the only end organ showed a trend toward improved survival (HR 1.6, p=0.06) (Table 1). Specifically for PA patients (n=79); treatment before autoSCT was associated with improved 3-yr OS: 85% vs. 66%; p=0.02. Conclusions: AL patients should be evaluated for AutoSCT and selected patients should undergo induction therapy to decrease amyloid burden prior to AutoSCT. Disclosures: No relevant conflicts of interest to declare.
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Shinohara, Tsutomu, Makiko Yamashita, Akihito Nishiyama, Shoutaro Tsuji, Ruth Ann Henriksen, and Quentin N. Myrvik. "Differential regulation of cyclooxygenase (COX) isoforms in alveolar (AM) and peritoneal macrophages (PM) from heat-killed Mycobacterium bovis BCG treated mice (91.5)." Journal of Immunology 178, no. 1_Supplement (April 1, 2007): S160—S161. http://dx.doi.org/10.4049/jimmunol.178.supp.91.5.
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Abstract Macrophage COX-2, a rate-limiting enzyme for the increased synthesis of PGE2, a mediator of inflammatory and immune responses against infections, is induced by intracellular bacteria. However, little is known about the regulation of expression of COX-2 or COX-1 by different tissue macrophages in response to bacteria in vivo. In this study, AM and PM were isolated from C57Bl/6 mice 24 hr following intranasal or intraperitoneal administration of BCG, 0.5 mg or 1 mg, respectively. As comparison controls, normal AM and PM were treated in vitro with 20 μg/ml BCG. Expression of COX-1 and COX-2 was determined by confocal microscopy and western blot. We found that in vivo BCG induced COX-2 expression in local AM or PM. The constitutive expression of COX-1 in PM was down-regulated by in vivo BCG. For AM, COX-1 levels, which were minimal in untreated cells, were slightly increased by in vivo BCG. Following in vivo BCG, neither COX-1 nor COX-2 in PM or AM was localized in the nuclear envelope (NE), indicating catalytically inactive forms. Treatment with BCG in vitro induced catalytically active COX-2 expression in AM and PM, but there was no effect on COX-1 expression or activity. Thus, following in vivo treatment with BCG, the profile of COX-1 expression by local macrophages is tissue dependent. However, the formation of catalytically inactive COX-2/COX-1 in response to in vivo BCG is tissue-independent. The formation of macrophages with catalytically inactive COX isoforms and diminished PGE2 production may result in enhanced immune responses against intracellular infections. (NIH RO1 HL71711, DOD DAMD 17-03-1-0004)
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Souissi, Amine, Narimen Yousfi, Nizar Souissi, Monoem Haddad, and Tarak Driss. "The effect of diurnal variation on the performance of exhaustive continuous and alternated-intensity cycling exercises." PLOS ONE 15, no. 12 (December 31, 2020): e0244191. http://dx.doi.org/10.1371/journal.pone.0244191.
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The purpose of this study was to explore the effect of time of day (TD) on two types of exercise protocols [continuous (CP) versus alternated (AP)]. Eleven physical education students (mean ± SD: age = 24.4 ± 1.2 years, aerobic peak power (APP) = 290 ± 31.9 W) underwent four sessions. These sessions were performed at 08:00 (AM) and 18:00 (PM) and consisted of cycling exercises until voluntary exhaustion at 90% APP (CP) or 70%-105% APP (AP) with the order of testing randomly assigned. Time to exhaustion (time limit = Tlim) was measured from the start of the test to when voluntary exhaustion occurred. Heart rate (HR) was recorded at baseline (HRbaseline) and throughout the protocols to determine HR at exhaustion (HRpeak). Blood lactate ([La]) was measured at rest, immediately after exhaustion and at 2min30 post-exercise to determine [La]peak. A significantly higher means of Tlim (334 ± 57 s; 272 ± 59 s; p< 0.05), HRbaseline (72 ± 5 beats/min; 67 ± 5 beats/min; p< 0.01), HRpeak (186 ± 8 beats/min; 178 ± 9 beats/min; p< 0.01) and [La]peak (16.2 ± 2.1 mmol/l; 13.9 ± 1.9 mmol/l; p< 0.05) were observed in CP at the PM compared to the AM. In addition, a significant higher means of Tlim (380 ± 54 s; 312 ± 82 s; p< 0.05), HRbaseline (73.1 ± 5.5 beats/min; 67 ± 5.4 beats/min; p< 0.01), HRpeak (186 ± 8 beats/min; 180 ± 9 beats/min; p< 0.05) and [La]peak (17.9 ± 1.8 mmol/l; 14.7 ± 2.1 mmol/l; p< 0.01) were observed in AP at the PM compared to the AM. It is concluded that AP and CP are more appropriate in the late afternoon than in the morning for performing long-lasting exercises. The AP could be a novel strategy for increasing the engagement in physical activity.
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O’Donoghue, Katriona J. M., Paul A. Fournier, and Kym J. Guelfi. "Lack of Effect of Exercise Time of Day on Acute Energy Intake in Healthy Men." International Journal of Sport Nutrition and Exercise Metabolism 20, no. 4 (August 2010): 350–56. http://dx.doi.org/10.1123/ijsnem.20.4.350.
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Although the manipulation of exercise and dietary intake to achieve successful weight loss has been extensively studied, it is unclear how the time of day that exercise is performed may affect subsequent energy intake. The purpose of the current study was to investigate the effect of an acute bout of exercise performed in the morning compared with an equivalent bout of exercise performed in the afternoon on short-term energy intake. Nine healthy male participants completed 3 trials: morning exercise (AM), afternoon exercise (PM), or control (no exercise; CON) in a randomized counterbalanced design. Exercise consisted of 45 min of treadmill running at 75% VO2peak. Energy intake was assessed over a 26-hr period with the participants eating ad libitum from a standard assortment of food items of known quantity and composition. There was no significant difference in overall energy intake (M ± SD; CON 23,505 ± 6,938 kJ, AM 24,957 ± 5,607 kJ, PM 24,560 ± 5,988 kJ; p = .590) or macronutrient preferences during the 26-hr period examined between trials. Likewise, no differences in energy intake or macronutrient preferences were observed at any of the specific individual meal periods examined (i.e., breakfast, lunch, dinner) between trials. These results suggest that the time of day that exercise is performed does not significantly affect short-term energy intake in healthy men.
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McCullough, Patrick E., Haibo Liu, Lambert B. McCarty, and Joe E. Toler. "Bermudagrass Putting Green Performance Influenced by Nitrogen and Trinexapac-ethyl." HortScience 41, no. 3 (June 2006): 802–4. http://dx.doi.org/10.21273/hortsci.41.3.802.
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Dwarf-type bermudagrass (Cynodon dactylon Pers. × C. transvaalensis Burtt-Davy) putting greens tolerate long-term mowing heights of 3.2 mm but require heavy nitrogen (N) fertilizations that increase ball roll resistance. Applying a plant growth regulator, such as trinexapac-ethyl (TE), could reduce uneven shoot growth from high N fertility and improve putting green ball roll distances. Field experiments were conducted from April to August 2003 and 2004 in Clemson, SC to investigate effects of ammonium nitrate applied at 6, 12, 18, or 24 kg N/ha per week with TE applied at 0 or 0.05 kg a.i. per ha every 3 weeks on `TifEagle' bermudagrass ball roll distances (BRD). BRD were measured weekly with a 38-cm stimpmeter in the morning (900 to 1100 hr) and evening (>1700 hr) beginning 1 wk after initial TE treatments. Interactions were not detected among N, TE, or time of day. TE increased BRD about 15% from non-TE treated. BRD was reduced with increased N rate and from am to pm; however, bermudagrass treated with TE averaged 10% longer PM BRD than am distances of non-TE treated. Overall, increased N fertility and diurnal shoot growth may reduce BRD but TE will be an effective tool for mitigating these effects on bermudagrass putting greens. Chemical name used: [4-(cyclopropyl-[α]-hydroxymethylene)-3,5-dioxo-cyclohexane carboxylic acid ethyl ester] (trinexapac-ethyl).
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Cook, Monte. "Descartes' Doubt of Minds." Dialogue 27, no. 1 (1988): 31–39. http://dx.doi.org/10.1017/s0012217300019478.
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Early in the Second Meditation Descartes has found grounds to doubt his previous opinions, and following his resolve to reject as false anything not entirely indubitable, he rejects these opinions. He then asks whether there might remain something impervious to doubt that he has not yet considered. One item as yet unconsidered is his own existence:I myself, am I not at least something? But I have already denied that I had senses and body. Yet I hesitate, for what follows from that? Am I so dependent on body and senses that I cannot exist without these? But I was persuaded that there was nothing in all the world, that there was no heaven, no earth, that there were no minds, nor any bodies: was I not then likewise persuaded that I did not exist? (HR I, 150)
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Ho, Yunn-Shy, Kenneth C. Sanderson, and J. C. Williams. "Effect of Chemicals and Photoperiod on the Growth and Flowering of Thanksgiving Cactus." Journal of the American Society for Horticultural Science 110, no. 5 (September 1985): 658–62. http://dx.doi.org/10.21273/jashs.110.5.658.
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Abstract Schlumbergera truncata (Haw.) Moran ‘Christmas Charm’, ‘Lavender Doll’, and ‘White Christmas’ were grown under an 8 hr natural photoperiod or an 8 hr natural photoperiod plus 4 hr of incandescent light from 10:00 pm to 2:00 am and treated with single sprays of BA at 100 and 200 ppm, GA at 25, 50, and 100 ppm, BA at 100 and 200 ppm plus GA at 25 or 100 ppm, calcium carbide at 2910 ppm, ethephon at 100 and 1000 ppm, daminozide at 5000 ppm, ancymidol at 132 ppm, and chlormequat at 1000 ppm in 2 experiments. No flower buds were initiated from any plants grown under the 8 + 4 hr photoperiod. BA applied at 100 and 200 ppm increased the number of phylloclades on ‘Christmas Charm’ plants grown under the 8 + 4 hr. BA at 200 ppm applied to plants grown under the 8 hr photoperiod caused an increase in flower bud number and earlier flowering in all cultivars tested. BA + 100 or 200 ppm 100 ppm GA applied to plants grown under the 8 hr + 4 hr photoperiod stimulated the growth and elongation of phylloclades. Applied to plants grown under the 8 hr photoperiod, BA plus GA caused the growth and elongation of phylloclades, initiation of lower buds, and induced the development of lateral phylloclades and flower buds. Ancymidol at 132 ppm and 1000 ppm chlormequat sprays produced earlier flower bud initiation and increased flower number to flower bud ratios on ‘Christmas Charm’ plants. Chemical names used: N-(phenylmethyl)-H-purin-6-amine (BA); gibberellic acid (GA); (2-chloroethyl)phosphonic acid (ethephon); butanedioic acid mono(2,2-dimethylhydrazide) (daminozide); α-cycloproply-α-4-methoxyphenyl)-5-pyrimidinemethanol) (ancymidol).
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Sanderson, Kenneth C., Yunn-Shy Ho, Willis C. Martin, and R. Bruce Reed. "Effect of Photoperiod and Growth Regulators on Growth of Three Cactaceae." HortScience 21, no. 6 (December 1986): 1381–82. http://dx.doi.org/10.21273/hortsci.21.6.1381.
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Abstract Chamaecereus silvestri (Spreg.) Britt & Rose ‘Peanut cactus’, Mammillaria elongata D.C. ‘Gold Star’, and Opuntia microdasys (Lehm.) Pfeiff. ‘Bunny Ears’ were grown on an 8-hr natural photoperiod (short) or an 8-hr natural plus 4-hr incandescent light from 10:00 pm to 2:00 am photoperiod (long) and treated with single sprays of growth regulators. Ethephon or the long photoperiod increased shoots on Opuntia. Gibberellic acid alone or BA alone increased Mammillaria and Chamaecereus shoot number linearly, whereas GA plus BA reduced shoot number. Chamaecereus and Opuntia plants grown on a long photoperiod produced more shoots than plants grown on the short photoperiod. Ethephon reduced the dry weight of all cacti tested. Dry weight of untreated Mammillaria and Opuntia plants exceeded that of growth regulator-treated plants. Opuntia plants produced more dry weight on the long photoperiod than on the short photoperiod. GA increased the growth of glochids on Opuntia and Mammillaria. Chemical names used: A-(phenylmethyl-1H-purin-6-amine (BA); (2-chloroethyl)phosphonic acid (ethephon); and gibberellic acid (GA).
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Rothausen, Teresa J. "Understanding Deep, Socially Embedded Human Motivations and Aspirations for Work From Whole Person and Interdisciplinary Perspectives." Industrial and Organizational Psychology 9, no. 4 (December 2016): 735–39. http://dx.doi.org/10.1017/iop.2016.82.
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As someone trained exclusively as a quantitative researcher, who recently became a semi-autodidactic qualitative researcher (see Rothausen, Henderson, Arnold, & Malshe, in press; “semi” in part because I am still learning and in part because my coauthors have taught me), I would like to extend the argument made by Pratt and Bonaccio (2016) for increasing qualitative research in the domains of industrial–organizational psychology (IOP), organizational behavior (OB), and human resources (HR), and I would also add industrial relations (IR), which was my doctoral field of study and “where workers went” within business and management studies as HR became more aligned with organizational interests (see Lefkowitz, 2016, from this journal). I extend their argument by deepening one of their reasons, understanding the “why” of work, and adding another potential use, understanding the “what could be” of work.
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Sherwood, Robert L., Peter T. Thomas, William J. O'shea, Jeannie N. Bradof, Helen V. Ratajczak, Judith A. Graham, and Catherine Aranyi. "Effects of Inhaled Hexachlorobenzene Aerosols on Rat Pulmonary Host Defenses." Toxicology and Industrial Health 5, no. 3 (July 1989): 451–61. http://dx.doi.org/10.1177/074823378900500306.
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Pulmonary bactericidal activity, macrophage phagocytic activity, alveolar macrophage (AM) enzyme activity, and T- and B-cell mitogenesis of lymphocytes from lung associated lymph nodes (LALN) or mesenteric lymph nodes (MESLN) were assessed in Sprague-Dawley rats exposed 4 hr/d, 4 days/wk for 1, 4, or 16 days to hexachlorobenzene (HCB) aerosols. Pulmonary bactericidal activity was depressed after 1 or 4 but not 16 exposures to 35 mg/m3 of HCB. AM phagocytosis of 51Cr-RBC in vitro was increased after 4 but not 1 or 16 exposures to HCB, and no effect was observed in peritoneal macrophages. HCB significantly enhanced mitogenesis in MESLN to the B-cell mitogen Salmonella typhimurium lipopolysaccharide (STM) after 4 exposures; LALN STM mitogenesis and LALN and MESLN mitogenesis to phytohemagglutinin (PHA) were not affected. After 16 exposures, however, the PHA responses in LALN and MESLN were significantly increased and decreased, respectively.
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Dušek, Martin, Jana Olšovská, Karel Krofta, Marie Jurková, and Alexandr Mikyška. "Qualitative Determination of β-Acids and Their Transformation Products in Beer and Hop Using HR/AM-LC-MS/MS." Journal of Agricultural and Food Chemistry 62, no. 31 (July 28, 2014): 7690–97. http://dx.doi.org/10.1021/jf501852r.
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Nakamura, Takeshi, and Hreday N. Sapru. "Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 6 (June 2009): H2022—H2029. http://dx.doi.org/10.1152/ajpheart.00191.2009.
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Urocortin 1 (Ucn1) and urocortin 3 (Ucn3) are new members of the corticotrophin-releasing factor (CRF) peptide family. Ucn1 is a ligand for both the CRF type 1 receptors (CRF1Rs) and the CRF type 2 receptors (CRF2Rs), whereas Ucn3 is a high-affinity ligand for the CRF2Rs. Recently, we reported that Ucn3 microinjections into the medial nucleus tractus solitarius (mNTS) elicit decreases in mean arterial pressure (MAP) and heart rate (HR) (Nakamura T, Kawabe K, Sapru HN. Am J Physiol Heart Circ Physiol 296: H325–H332, 2009). The presence of CRF2Rs on afferent terminals has been reported in the mNTS of the rat. It was hypothesized that activation of CRF2Rs on afferent terminals in the mNTS may release glutamate, which, in turn, may elicit decreases in MAP and HR via activation of ionotropic glutamate receptors (iGLURs). This hypothesis was tested in urethane-anesthetized, artificially ventilated, adult male Wistar rats. Microinjections (100 nl) of Ucn1 (0.12 mM) into the mNTS elicited decreases in MAP and HR. The responses were partially blocked by microinjections of iGLUR antagonists into the mNTS. On the other hand, the decreases in MAP and HR elicited by microinjections of Ucn3 (0.06 mM) into the mNTS were completely blocked by microinjections of iGLUR antagonists into the mNTS. These results indicate that activation of CRF2Rs in the mNTS, by Ucn1 and Ucn3, releases glutamate, which, in turn, elicits decreases in MAP and HR via activation of iGLURs.
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Levy, Moshe Yair, Lin Xie, Yuexi Wang, Frank Neumann, Shouryadeep Srivastava, Daniel Naranjo, Jing Xu, Qisu Zhang, and Mehul Dalal. "Major Adverse Cardiac, Arterial Occlusive, and Venous Occlusive Events Among Chronic Myeloid Leukemia Patients Prescribed Ponatinib Vs Bosutinib." Blood 134, Supplement_1 (November 13, 2019): 4751. http://dx.doi.org/10.1182/blood-2019-129053.
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INTRODUCTION: Chronic myeloid leukemia (CML) is a bone marrow and blood disorder accounting for 15% of adult leukemia. Tyrosine kinase inhibitors (TKIs) have been the standard of care for CML treatment. However, an association between TKI use and cardiovascular events has been observed. Ponatinib and bosutinib are introduced to provide more options for patients who failed their first-line treatment. The incidence of major adverse cardiac events (MACEs), arterial occlusive events (AOEs), and venous occlusive events (VOEs) were assessed among CML patients who were prescribed ponatinib vs bosutinib. METHODS: A retrospective observational study was conducted among adult CML patients aged ≥18 years with use of 1 or 2 prior TKIs who were prescribed bosutinib or ponatinib. Study patients were selected from the IBM® MarketScan® Research database from July 2012-June 2017. The index date was defined as the index drug prescription date, identified based on TKI use during the identification period (January 2013-December 2016) in a hierarchical order based on the sequence of treatment lines: ponatinib and bosutinib without ponatinib. Continuous health plan enrollment for ≥6 months pre-index date (baseline period) and at least 6 months post-index date (follow-up period) was required. Cardiovascular (CV) events (MACEs, AOEs, VOEs) using ICD-9/10-CM diagnosis codes occurring through the earliest of index TKI discontinuation, switch to another TKI, or end of follow-up period, were calculated as the number of events per 100 person-years (PYs). Inverse probability of treatment weighting (IPTW) was applied to adjust for differences in baseline characteristics between the treatment cohorts. Kaplan-Meier (KM) and Cox proportional hazard model analyses were conducted on the adjusted sample to examine any difference in CV event risk. RESULTS: After applying the selection criteria, 79 and 109 patients were included in the ponatinib and bosutinib cohorts, respectively. Mean ages were 53 years (ponatinib cohort) and 58 years (bosutinib cohort). The average Charlson Comorbidity Index (CCI) scores - defined by categorizing comorbidities using diagnosis codes - were 1.23 for ponatinib and 1.81 for the bosutinib cohort. Common baseline comorbid conditions included anemia (ponatinib: 49%; bosutinib 34%), hypertension (ponatinib: 33%, bosutinib: 46%), and diabetes (ponatinib: 15%; bosutinib: 29%). Some patients were observed to have CV events, specifically MACEs (ponatinib 8%; bosutinib 16%) and AOEs (ponatinib 15%; bosutinib 28%), before index ponatinib or bosutinib use. In the follow-up period, ponatinib patients were associated with a similar incidence of MACEs (14.70 vs 10.46 per 100 PYs; p=0.464), AOEs (29.56 vs 34.50 per 100 PYs; p=0.632), and VOEs (36.21 vs 34.70 per 100 PYs; p=0.890) compared to bosutinib patients. After applying IPTW, similar risks of the CV events (MACE, AOEs, VTEs) were observed in the KM analysis (Figure 1) expressed as time to CV event. After adjusting for additional confounders using Cox models, compared to those with bosutinib use, ponatinib patients were associated with similar rate of MACEs (Hazard Ratio [HR]: 1.02; 95% CI: 0.34, 3.01), AOEs (HR: 0.90; 95% CI: 0.43, 1.85), and VOEs (HR: 0.92; 95% CI: 0.44, 1.94). CONCLUSION: Among CML patients treated with ponatinib or bosutinib in second or third line, similar risks of cardiovascular events (MACE, AOEs, VTEs) were observed in the follow-up in this study in a community setting. Figure 1 Disclosures Levy: Takeda (Millennium Pharmaceuticals): Consultancy. Xie:STATinMED Research: Other: I am a paid employee of STATinMED Research which is a paid consultant to Takeda Pharmaceutical Corporation. . Wang:STATinMED Research: Other: I am a paid employee of STATinMED Research which is a paid consultant to Takeda Pharmaceutical Company. . Neumann:Millennium Pharmaceuticals (Takeda): Employment, Other: I am a paid employee of Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd. Srivastava:Millennium Pharmaceuticals (Takeda): Other: I am a paid employee of Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd. Naranjo:Millennium Pharmaceuticals (Takeda): Other: I am a paid employee of Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd. Xu:Millennium Pharmaceuticals (Takeda): Other: I am a paid employee of Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd. Zhang:STATinMED Research: Other: I am a paid employee of STATinMED Research which is a paid consultant to Takeda Pharmaceutical Corporation.. Dalal:Millennium Pharmaceuticals (Takeda): Other: I am a paid employee of Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd.
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Lokhande, Manohar V. "Structural elucidation, Identification, quantization of process related impurity in Hydralazine Hydrochloride HR/AM- LC MS/MS, NMR and FTIR technique." IOSR Journal of Applied Chemistry 6, no. 2 (2013): 05–15. http://dx.doi.org/10.9790/5736-0620515.
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Huang, Bing S., Bruce N. Van Vliet, and Frans H. H. Leenen. "Increases in CSF [Na+] precede the increases in blood pressure in Dahl S rats and SHR on a high-salt diet." American Journal of Physiology-Heart and Circulatory Physiology 287, no. 3 (September 2004): H1160—H1166. http://dx.doi.org/10.1152/ajpheart.00126.2004.
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In Dahl salt-sensitive (S) and salt-resistant (R) rats, and spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats, at 5–6 wk of age, a cannula was placed in the cisterna magna, and cerebrospinal fluid (CSF) was withdrawn continuously at 75 μl/12 h. CSF was collected as day- and nighttime samples from rats on a regular salt intake (0.6% Na+; R-Na) and then on a high salt intake (8% Na+; H-Na). In separate groups of rats, the abdominal aorta was cannulated and blood pressure (BP) and heart rate (HR) measured at 10 AM and 10 PM, with rats first on R-Na and then on H-Na. On H-Na, CSF [Na+] started to increase in the daytime of day 2 in Dahl S rats and of day 3 in SHR. BP and HR did not rise until day 3 in Dahl S rats and day 4 in SHR. In Dahl R and WKY rats, high salt did not change CSF [Na+], BP, or HR. In a third set of Dahl S rats, sampling of both CSF and BP was performed in each individual rat. Again, significant increases in CSF [Na+] were observed 1–2 days earlier than the increases in BP and HR. In a fourth set of Dahl S rats, BP and HR were recorded continuously by means of radiotelemetry for 5 days on R-Na and 8 days on H-Na. On H-Na, BP (but not HR) increased first in the nighttime of day 2. In another set of Dahl S rats, intracerebroventricular infusion of antibody Fab fragments binding ouabain-like compounds (OLC) with high affinity prevented the increase in BP and HR by H-Na but further increased CSF [Na+]. Finally, in Wistar rats on H-Na, intracerebroventricular infusion of ouabain increased BP and HR but decreased CSF [Na+]. Thus, in both Dahl S and SHR on H-Na, increases in CSF [Na+] preceded the increases in BP and HR, consistent with a primary role of increased CSF [Na+] in the salt-induced hypertension. An increase in brain OLC in response to the initial increase in CSF [Na+] appears to attenuate further increases in CSF [Na+] but at the “expense” of sympathoexcitation and hypertension.