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Journal articles on the topic "HR 1817"
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Budding, E., B. D. Carter, M. W. Mengel, O. B. Slee, and J. F. Donati. "A Radio and Optical Study of the Active Young F Star HR 1817 (=HD 35850)." Publications of the Astronomical Society of Australia 19, no. 4 (2002): 527–33. http://dx.doi.org/10.1071/as02021.
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AbstractThis paper presents the results of a multiwavelength observational study of the active young F-type star HR 1817. The star was monitored at 4.80 and 8.64 GHz over 2 × 12 h allocations with the Australia Telescope Compact Array on 8 and 9 December, 2000. The Anglo-Australian Telescope was used for simultaneous optical spectropolarimetry during a 2 h period on 9 December.The low levels of observed radio emission have characteristics that are similar to those seen in other active stars, and a gyrosynchrotron mechanism is proposed to explain them; this is supported by the relatively low fractions of circular polarisation measured in HR 1817.Comparison of the emissions from 4.80 and 8.64 GHz shows a very strong cross-correlation peak, indicative of a common origin, although the shift of this peak indicates that 8.64 GHz variations tend to precede those at 4.80 GHz by, typically, ˜20 min.The optical spectropolarimetry reveals polarisation signals characteristic of surface magnetic fields, with profile changes indicating a complex dynamo-type magnetic topology is present on the star. This result makes HR 1817 the star with the earliest spectral type on which dynamo magnetic fields have been detected directly up to now.
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Pavlenko, O., I. Maksymenko, Ie Lapin, and V. Kasianenko. "ANALYSIS OF THE EFFICIENCY OF PERSONNEL WORK AS AN ELEMENT OF THE ENTERPRISE BUSINESS PROCESS." Vìsnik Sumsʹkogo deržavnogo unìversitetu, no. 1 (2019): 77–81. http://dx.doi.org/10.21272/1817-9215.2019.1-10.
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Nowadays, the search for the effective tools in a sphere of personnel management are still on, and these issues is crucial especially for the Ukrainian enterprises. The article is aimed to analyze the effectiveness of staff as an element of the business-processes system of an enterprise. Among all the approaches the authors put their attention to evolutional and revolutional approaches to reengineering of the business-processes, and the key role of the personnel in these processes. Particular attention was given to the identification of personnel management essence in terms of business-process management, the pathways of optimizations of the business-processes, .and the main problems of HR-management that can be identified under the audit process. The case methodology was used to reveal the best practices in the improvement of HR-management system. Keywords: personnel, business process, analysis, enterprise, management.
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Telyshevska, L., and V. Uspalenko. "The trends in the development of the HR management system at the enterprise." Economic Herald of the Donbas, no. 2 (56) (2019): 187–97. http://dx.doi.org/10.12958/1817-3772-2019-2(56)-187-197.
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Lukianykhin, V., O. Lukianykhina, and Ya Sorokolit. "FINANCIAL INCLUSION AS A DRIVER PROVIDING FINANCIAL SECURITY IN UKRAINE." Vìsnik Sumsʹkogo deržavnogo unìversitetu, no. 2 (2020): 79–89. http://dx.doi.org/10.21272/1817-9215.2020.2-9.
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The article explores and summarizes the approaches of scientists to the definition of "personnel management", forms the author's definition as a set of interrelated methods, principles and forms of organizational mechanism for the formation, reproduction, development and utilization of personnel, creating optimal work conditions and employee motivation. The application of personnel management methods in successful business entities is analyzed on the example of companies included in the rankings of the best employers of Ukraine, in particular, whose production facilities are located in Sumy region - "Mondelis Ukraine" (Trostyanets) and "Farmak" (Shostka). It is concluded that the successful implementation of personnel management strategy (HR-strategy) is possible only with the correct composition of tools of administrative and economic influence, which can be supported (depending on financial capacity, management sentiment, accepted business practices, etc.) by socio-psychological methods. According to Hay-McBerAssociates' approach, six leadership styles have been identified. The author's vision presents their evolution (from the use of mostly administrative to the most modern methods (including coaching). The personnel management system of the «Sumy Road Maintenance Department Branch» has been studied. An assessment of the capabilities of this company to improve the efficiency of the existing personnel management system was made. Proposals for modernization of personnel management policy within the framework of administrative and economic methods in their interconnection and effective interaction are given. The most appropriate style of personnel management at the current stage of development of the organization is "visionary", which contributes to the formation of a successful long-term development strategy and the creation of perspectives for staff. But in today's reality, this style must be abandoned with the prospect of moving to a democratic version, reducing the share of administrative methods and increasing the importance of economic methods as more progressive methods of stimulating labor. In addition, it is determined that to increase the efficiency of personnel management of the Branch it is proposed to use modern HR-software with the use of cloud technologies for application in management activities. The analysis of IT-operators and their products allowed to identify quite interesting proposals (Microsoft, SAP, Terrasoft), but the main limitation to the use of these programs in the activities of the Branch is the high cost of use (up to 50,000 UAH / month). That is why we offer to utilize the software product "PeopleHR" of the company "PeopleFource", which has not yet gained much popularity in the Ukrainian market. This is a fairly full-featured program aimed at medium-sized businesses. It was also decided to focus on the system of additional bonuses for staff depending on the length of service and compliance with labour discipline, as the most effective method of improving the efficiency of employees.
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Zhulavskiy, A., V. Hordiienko, and N. Malko. "PROFESSIONAL COMPETENCE OF CIVIL SERVANTS AS A FACTOR OF SUCCESS OF PUBLIC MANAGER." Vìsnik Sumsʹkogo deržavnogo unìversitetu, no. 4 (2020): 152–57. http://dx.doi.org/10.21272/1817-9215.2020.4-17.
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The article is devoted to the actual issues of professional competence of civil servants in the system of effective public administration. It was found out that official duties of a state body require professional knowledge and certain competencies of a civil servant how to properly apply them. The analysis of the legislative and regulatory framework in the field of civil service shows that a concept as "professional competence of civil servants." Undergoes formation of its foundations and development. The precondition for the formation of competencies for an employee is determined by the position requirements and job responsibilities. The role of the head of the state body, his/her vision and style of management of the institution and staff, his/her fairness and professionalism in the selection of specialists play an important role. The analysis of the procedure of civil servant evaluation, servant’s activities during the last year and the effectiveness of the tasks set by the head of the civil service indicates a constant need to increase the level of professional competence of the employees. Activities of an HR specialist or service, who is responsible for supporting employees in personal, professional and competence growth through elaborating individual plans and training schemes. Approaches to evaluate activities of civil servants and impact of these activities were identified. The current state of implementation of the system of training and re-training, the basic requirements and types of educational services, platforms, including online, were assessed. Basic requirements to professional competence of civil servants necessary for effective work of public authorities were identified. The ways to solve and improve the mechanisms of realization civil service policies, namely improvement of the system of increase of professional competence of civil servants, were suggested. Considering the long-term public administration reform in Ukraine, the government's focus on the gradual provision of public institutions with competent and professional employees who would meet European standards, was identified.
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Karu, Einar, Mengze Li, Lisa Ernle, Carl A. M. Brenninkmeijer, Jos Lelieveld, and Jonathan Williams. "Atomic emission detector with gas chromatographic separation and cryogenic pre-concentration (CryoTrap–GC–AED) for atmospheric trace gas measurements." Atmospheric Measurement Techniques 14, no. 3 (March 4, 2021): 1817–31. http://dx.doi.org/10.5194/amt-14-1817-2021.
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Abstract. A gas detection system has been developed, characterized, and deployed for pressurized gas-phase sample analyses and near-real-time online measurements. It consists of a cryogenic pre-concentrator (CryoTrap), a gas chromatograph (GC), and a new high-resolution atomic emission detector (AED III HR). Here the CryoTrap–GC–AED instrumental setup is presented, and the performance for iodine (1635 ± 135 counts I atom−1 pptv−1), sulfur (409 ± 57 counts S atom−1 pptv−1), carbon (636 ± 69 counts C atom−1 pptv−1), bromine (9.1 ± 1.8 counts Br atom−1 pptv−1), and nitrogen (28 ± 2 counts N atom−1 pptv−1) emission lines is reported and discussed. The limits of detection (LODs) are in the low parts per trillion by volume range (0.5–9.7 pptv), and the signal is linear to at least 4 orders of magnitude, which makes it a suitable method for diverse volatile organic compound (VOC) measurements in the atmosphere, even in remote unpolluted regions. The new system was utilized in a field study in a boreal forest at Hyytiälä, Finland, in late summer 2016, which made monoterpene measurements possible among other VOCs. Furthermore, pressurized global whole-air samples, collected on board the Lufthansa Airbus A340-600 IAGOS–CARIBIC aircraft in the upper troposphere and lower stratosphere region, were measured with the new setup, providing data for many VOCs, including the long-lived organosulfur compound carbonyl sulfide.
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Pestaña-Fernández, Melani, Manuel Rubio-Rivas, Carles Tolosa-Vilella, Alfredo Guillén-Del-Castillo, Mayka Freire, Jose Antonio Vargas-Hitos, Jose Antonio Todolí-Parra, et al. "Longterm Efficacy and Safety of Monotherapy versus Combination Therapy in Systemic Sclerosis–associated Pulmonary Arterial Hypertension: A Retrospective RESCLE Registry Study." Journal of Rheumatology 47, no. 1 (February 15, 2019): 89–98. http://dx.doi.org/10.3899/jrheum.180595.
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Objective.Monotherapy is an option as first-line therapy for pulmonary arterial hypertension (PAH). However, combination therapy is a beneficial alternative. Our objective was to evaluate the efficacy of monotherapy versus combination therapy in patients with systemic sclerosis (SSc)–associated PAH.Methods.All patients with SSc-associated PAH from the Spanish Scleroderma Registry (RESCLE) were reviewed. Patients were split into 3 groups: monotherapy versus sequential combination versus upfront combination therapy. The primary endpoint was death from any cause at 1, 3, and 5 years from PAH diagnosis.Results.Seventy-six patients (4.2%) out of 1817 had SSc-related PAH. Thirty-four patients (45%) were receiving monotherapy [endothelin receptor antagonist (n = 22; 29%) or phosphodiesterase-5 inhibitors (n = 12; 16%)], 25 (33%) sequential combination, and 17 (22%) upfront combination therapy. A lower forced vital capacity/DLCO in the sequential combination group was reported (2.9 ± 1.1 vs 1.8 ± 0.4 vs 2.3 ± 0.8; p = 0.085) and also a higher mean pulmonary arterial pressure in combination groups (37.2 ± 8.7 mmHg vs 40.8 ± 8.8 vs 46 ± 15.9; p = 0.026) at baseline. Treatment regimen (p = 0.017) and functional class (p = 0.007) were found to be independent predictors of mortality. Sequential combination therapy was found to be an independent protective factor (HR 0.11, 95% CI 0.03–0.51; p = 0.004), while upfront combination therapy showed a trend (HR 0.68, 95% CI 0.23–1.97; p = 0.476). Survival from PAH diagnosis among monotherapy, sequential, and upfront combination groups was 78% versus 95.8% versus 94.1% at 1 year, 40.7% versus 81.5% versus 51.8% at 3 years, and 31.6% versus 56.5% versus 34.5% at 5 years (p = 0.007), respectively. Side effects were not significantly different among groups.Conclusion.Combination sequential therapy improved survival in our cohort.
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Sawyer, M. B., S. Damaraju, E. Pituskin, V. Damaraju, A. G. Scarfe, R. B. Bies, J. Hanson, M. Clemons, M. Kuzma, and J. R. Mackey. "Uridine glucuronosyltransferase 2B7 pharmacogenetics predicts epirubicin clearance and myelosuppression." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 2504. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.2504.
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2504 Background: Epirubicin (EPI) is widely used to treat breast cancer. EPI is predominantly metabolized by uridine glucuronosyltransferase (UGT) 2B7 to inactive glucuronides. We previously showed that a UGT enhancer single nucleotide polymorphism (SNP) at position -161 T to C correlated with rates of morphine glucuronidation. Methods: We performed a prospective pharmacogenetic study of effects of this SNP on EPI metabolism in M0 breast cancer patients (PTS) receiving adjuvant or neoadjuvant FEC100 (5-fluorouracil 500 mg/m2, EPI 100 mg/m2 and cyclophosphamide 500 mg/m2) given every 3 wks. PTS with ALT and AST ≤ upper limit of normal (ULN), a total bilirubin ≤ ULN, and normal renal and cardiac function were eligible. EPI levels were drawn at approximately 1 and 24 hrs. Cycle 1 toxicities were assessed using NCIC CTG toxicity criteria. Results: 123 PTS entered this study, mean (range): age 51 (28 - 74), sex 122 F/ 1 M, baseline AST 24 U/L (13–66), ALT 22 U/L (5–90), bilirubin 8 μmol/L (2–26), creatinine 74 μmol/L (50 - 126). PTS were genotyped using Pyrosequencing; 26 PTS were TT homozygotes, 59 were CT heterozygotes, and 33 were CC homozygotes. 5 PTS could not be genotyped. A three compartment population pharmacokinetic model in NONMEM V 1.1 for EPI was used incorporating all PTS. The baseline objective function was 1817, and inclusion of genotype significantly improved the objective function to 1764; CC genotype PTS had decreased EPI clearance 88.9 L/hr compared to CT/TT genotype PTS 129 L/hr, p<0.001. Rates of first cycle grade 3/4 leucopenia were 78% in CC PTS and 48% in CT/TT PTS; consistent with the pharmacokinetic analysis. Conclusions: A SNP in UGT 2B7 is common and appears to predicts EPI clearance and myelosuppresion in non-metastatic breast cancer PTS and may form the basis for a method to individualize EPI treatment. No significant financial relationships to disclose.
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Kaga, Yasuhiro, Yu Sunakawa, Yutaro Kubota, Teppei Tagawa, Taikan Yamamoto, Toshikazu Ikusue, Yu Uto, et al. "Early tumor shrinkage as a predictor of favorable outcomes in patients (pts) with advanced pancreatic cancer treated with FOLFIRINOX." Journal of Clinical Oncology 34, no. 4_suppl (February 1, 2016): 237. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.237.
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237 Background: Results from the phase III PRODIGE 4/ACCORD 11 trial provided one of current standard regimens for advanced pancreatic cancer (PC), consisting of oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX), which has superior response rate (RR) and survival benefit even with severe toxicity (Thierry C, et al. N Engl J Med 2011;364:1817-1825). There are several reports on the correlation between early tumor shrinkage (ETS) or depth of response (DpR) and survival in chemotherapies for colorectal cancer; however, few studies have investigated it in PC. We therefore analyzed retrospectively whether the ETS will predict outcomes in pts with PC treated with FOLFIRINOX therapy. Methods: Advanced PC pts with ECOG PS of 0 or 1, who received FOLFIRINOX as 1st- or 2nd-line treatment between November 2012 and July 2015 in 3 institutes of Showa University were included in this analysis. ETS was defined as a reduction ≥ 20% of target lesions’ diameters measured at 8 weeks from treatment start. We evaluated the association of ETS with progression-free survival (PFS) and overall survival (OS) but also addressed the correlation between outcomes and DpR, which was percentage of maximal tumor shrinkage observed at the nadir diameter compared with baseline. Results: Fifty-nine PC pts with median age of 63 (range 34-76) years and males of 68% were enrolled: 80% of pts had metastatic disease. In the population, RR, median PFS, and OS were 28%, 5.4 months, and 10.7 months, respectively. Among 46 (78%) evaluable pts for the ETS, 12 (26%) pts experienced ETS. The PFS was significantly longer in pts with ETS compared to pts with no ETS (9.0 vs. 4.2 months, HR 0.43, 95%CI 0.17-0.96, log-rank P= 0.045). Moreover, pts with ETS had a better OS although no statistical significance (HR 0.53, log-rank P= 0.25). Median DpR was 11.1% (from -75.7 to 100), and the correlation of DpR with clinical outcome was observed (P= 0.024 for PFS, P= 0.22 for OS). Conclusions: This retrospective analysis suggests that the early response to FOLFIRINOX treatment may predict better outcomes in pts with advanced PC. The ETS may serve as a novel predictor of prolonged survival time in PC pts treated with FOLFIRINOX.
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Cluzeau, Thomas, Guillaume Robert, Jean-Michel Karsenti, Frederic Luciano, Alexandre Puissant, S. Dominique Raynaud, Lionel Mannone, Jill-Patrice Cassuto, Nicolas Mounier, and Patrick Auberger. "Induction of Autophagic Cell Death Circumvents Azacitidine-Resistance In Myelodysplastic Syndrome-Derived Cell Lines." Blood 116, no. 21 (November 19, 2010): 1817. http://dx.doi.org/10.1182/blood.v116.21.1817.1817.
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Abstract Abstract 1817 Azacitidine (AZA) is the first line treatment for IPSS (index prognostic scoring system) high-risk myelodysplastic syndrome (HR-MDS). To date, only Khan et al. (Exp Hematol. 2008) and Hollenbach et al. (PLoS One. 2009) have reported apoptosis as a mechanism of AZA effect on MDS cell lines. Nevertheless, approximately 40% of patients treated with AZA are refractory to this molecule. To investigate the possible mechanisms of AZA resistance in MDS cells, we developped AZA-resistant cell clones (AZA-R) from the well-characterized MDS cell line SKM1. The bulk resistant SKM1 cell line (AZA-R) was obtained following long time exposure of cells to iterative and increasing doses of AZA ranging from 0.1 to 8mM. We first showed that AZA triggered loss of cell metabolism in SKM1 parental cells but not in their AZA-resistant counterpart at a maximally effective dose of 1mM. AZA-mediated loss of cell metabolism accounted mainly for induction of apoptosis as judged by both an increase in caspase 9 and 3 activities triggered by this compound and by a significant protection in the presence of the pan-caspase inhibitor Z-VAD-fmk in SKM1 parental cells. Conversely, no or very few activation of caspases and apoptosis were detected in AZA-R cells strongly suggesting that apoptosis is impaired in AZA-R SKM1 cells. Finally, unlike in SKM1 cells, AZA failed to induce mitochondrial membrane permeabilization in AZA-R SKM1 cells. Importantly, basal autophagy was increased in AZA-R versus AZA-S cells as shown by LC3-I cleavage into LC3-II, p62/SQSTM1 protein expression, cathepsin B activation, mTOR and S6 ribosomal protein dephosphorylation and finally electronic microscopy experiments. In addition, Acadesine, an adenosine derivative and AMPK agonist which targets autophagy was capable to circumvent AZA resistance in both AZA-R SKM1 cells and in medullary cells from five MDS patients resistant to AZA after 6 cycles of Azacitidine. In conclusion, targeting autophagy appears as an attractive therapeutical strategy to circumvent AZA resistance in both established MDS cell lines and cells from MDS patients. Therefore, drugs capable of inducing autophagy or autophagic cell death, such as Acadesine (Robert et al., PLoS One. 2009) which is currently in phase II clinical trials for the treatment of Chronic Lymphoblastic Leukemia could be also beneficial for HR-MDS patients resistant to AZA. Disclosures: Cluzeau: Celgene: Consultancy. Raynaud:Celgene: Consultancy.
Dissertations / Theses on the topic "HR 1817"
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Mengel, Matthew Wayne. "The active young solar-type star HR 1817 (=HD 35850)." University of Southern Queensland, Faculty of Sciences, 2005. http://eprints.usq.edu.au/archive/00001474/.
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The active F dwarf HR 1817 represents the upper temperature extreme of what are broadly termed solar-type stars - stars which have the same internal structure as the Sun, albeit in this case with a much smaller convective zone. To date, studies of the active surface features and magnetic fields of solar-type stars have been restricted to G and K dwarfs. This thesis investigates the surface and magnetic features of HR 1817 using the techniques of Doppler and Zeeman Doppler Imaging, resulting in tomographic maps of the stellar surface and magnetic field. Cooler stars than HR 1817 exhibit large polar spots, and while HR 1817 also exhibits a polar spot, it is not nearly as large as those usually seen. The lower-latitude surface features of HR 1817 are weak but well defined and cover a relatively small area of the stellar surface. Total spot coverage is relatively small (~ 1.7 - 2 per cent). Zeeman Doppler Imaging reveals that HR 1817 exhibits a richly-detailed, though weak magnetic topography. A ring of azimuthal field appears around the pole, while the radial field exhibits many well-defined and distinct bipolar mid-latitude magnetic features, perhaps indicating a more dominant interface dynamo as opposed to the posited distributed dynamo of cooler active dwarfs. Finally, a differential rotation measurement of the star indicates an extremely large rotational shear. Values for the equatorial rotation and rotational shear of 6.494 +/- 0.010 rad/d and 0.256 +/- 0.017 rad/d respectively are found. This equatorial rotation is equivalent to a rotational period for HR 1817 of ~ 0.98 days. The very high rotational shear of 0.256 rad/d is fast enough for the equator to lap the pole in approximately 23 days.
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Humphrey, James Stuart. "Group 15 and alkyne derivatives of HR₄CO₁₂BH₂." Thesis, University of Cambridge, 1995. https://www.repository.cam.ac.uk/handle/1810/273012.
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Pearson, Rose Alicia. "Automated modelling of cortical bone from clinical CT." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269745.
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Osteoporosis is an age-related skeletal disease characterised by an increased incidence of fragility fractures. In this thesis I develop a new technique capable of measuring the thickness of the previously unmeasured endocortical region, and providing an improved measure of the cortical bone mineral density (cBMD) from in-vivo clinical CT scans. These features are of interest as both have been linked to fracture risk. \\ The new technique is developed within the cortical bone mapping (CBM) framework so that it provides localised architectural measurements over a bone's surface. Its performance is assessed using simulated QCT data from three simulated phantoms with differing bone architecture, and two paired datasets of ex-vivo QCT and HR-pQCT scans across the proximal femur and the lumbar spine. The simulated data allows for inaccuracies in CBM measurements caused by beam hardening effects to be considered for the first time: I show that beam hardening leads to an underestimation in cortical thickness and an overestimation in trabecular BMD and that these inaccuracies can be reduced through adjustments to the CBM optimisation process. \\ A new technique of analysing HR-pQCT scans is also developed, for the validation of the new CBM method. It was used in place of other established HR-pQCT techniques for its ability to provide localised measurements of the endocortical region. A comparison with the well known full-width half-maximum (FWHM) method shows that it is less susceptible to errors caused by beam hardening. It also measures the mean cBMD, which has a greater clinical relevance than the peak cBMD measured by the FWHM method as it includes the impact of porosity. I demonstrate that the endocortical thickness can be measured to an accuracy of \(-0.15\pm0.71\thinspace\mathrm{mm}\), and that local cBMD measurements are possible down to \(300\thinspace\mathrm{mg/cm}^3\) from QCT scans over the proximal femur. I also validate CBM methods over the vertebrae for the first time and demonstrate that the cortical thickness and endocortical thickness can be measured with accuracies of \(0.10\pm0.30\thinspace\mathrm{mm}\) and \(-0.20\pm0.53\thinspace\mathrm{mm}\). \\ Two clinical trials involving Teriparatide are used to demonstrate that the new CBM method is able to detect significant regional changes in the dense cortical and endocortical bone over the proximal femur and lumbar spine, which can be attributed to changes in intracortical remodelling and endosteal apposition. The analysis of a cross-sectional fracture discrimination trial shows that fracture incidence is associated with significant decreases in endocortical thickness over specific regions.
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Riddell, Amy. "The muscle-bone in children and adolescents with and without cystic fibrosis." Thesis, University of Cambridge, 2016. https://www.repository.cam.ac.uk/handle/1810/268034.
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Introduction: Puberty is a crucial period for rapid changes in bone mineral, size, geometry, and microarchitecture. The mechanostat theory postulates that increased mechanical loading will affect bone phenotype and strength during development and in later life. Individuals with cystic fibrosis (CF) have an increased risk of developing osteoporosis and fragility fractures in young adulthood, which may be caused by poor growth. The aim was to investigate whether sex and disease status modified the relationship between: 1) puberty and bone, and 2) muscle and bone. This would contribute to the understanding of how sex (males vs. females) and disease group (CF vs.controls) alters the relationship between bone and muscle in children and adolescents as they transition through puberty and who, on a population level, differ in the prevalence of osteoporosis and risk of fracture in later life. Methods and Analyses: This observational study used novel imaging and muscle assessment techniques to measure bone and muscle parameters in White Caucasian children and adolescents, aged 8 to 16 years, living in the UK, with children with CF (n=65) and controls (n=151). Anthropometry and pubertal status were assessed. Dual energy X-ray absorptiometry, peripheral quantitative computed tomography (pQCT), high-resolution pQCT, and jumping mechanography were used to measure bone and muscle outcomes. ANCOVA with Scheffé post hoc and multiple linear regression tests were performed. Data were adjusted according to the research aims and included covariates; sex, disease group, pubertal stage, age, quadratic age, height, weight, maximum force (Fmax), and maximum power (Pmax). Data are presented as beta-coefficient (%) and p-value, with the significance level set to p < 0.05. Results: In height adjusted analyses, among healthy participants, females had smaller bones and lower bone density compared to males. With pubertal maturation, females had lower apparent gains in the distal and proximal total area (Tt.Ar and CSA), distal cortical porosity (Ct.Po) and proximal bone strength (SSI) but higher apparent gains in distal and proximal cortical bone density(Ct.BMD, Ct.TMD, vBMD). Females had consistently lower distal total area (total CSA) and density (total vBMD), distal trabecular density(BV/TV) and number(Tb.N), and proximal cortical area(CSA) compared to males, across all stages of puberty. With increasing muscle force (Fmax), females had higher apparent gains in total body less head bone mineral (TBLH BMC) and bone area(BA), distal total and trabecular density (total and trab vBMD) compared to males. In contrast, with increasing muscle power (Pmax), females had higher apparent gains in distal total and cortical densities (D100, Ct.BMD and Ct.TMD), and distal trabecular thickness (Tb.Th), and proximal cortical density (cortical vBMD) but lower apparent gains in distal cortical porosity (Ct.Po) and trabecular number (Tb.N) compared to males. In height adjusted analyses, participants with CF had smaller bones and lower bone density compared to controls. With increasing pubertal maturation, participants with CF had lower apparent gains in total body less head bone mineral and bone area, and in distal trabecular density, cortical porosity, and trabecular thickness compared to controls. Participants with CF had consistently lower distal total and cortical area, distal total and trabecular densities and proximal bone strength compared to controls, across all stages of puberty. With increasing muscle force, participants with CF had lower apparent gains in total body less head bone mineral and bone area, distal total density, trabecular density, and trabecular number. In contrast, with increasing muscle power (Pmax), participants with CF had higher apparent gains in distal trabecular density (BV/TV) and trabecular number (Tb.N) compared to controls. Conclusion: These findings suggests that sex and disease status do modify the relationships between puberty and bone, and between muscle function and bone. Skeletal adaptation to muscle differs between sexes and in populations with chronic disease, which may explain sex and disease group differences in risks of osteoporosis and fracture. Bone adaptation to muscle in children with CF is altered, which may lead to narrow, under-mineralised bones, with lower bone strength in later life. Understanding better impairments in muscle functions may provide targets for intervention to improve skeletal health in later life.
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Perrier, Guillaume. "Le fonctionnement de la mémoire contextuelle dans la lecture d'À la recherche du temps perdu de Marcel Proust : Albertine disparue et le temps retrouvé." Paris 7, 2009. http://www.theses.fr/2009PA070034.
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La mémoire contextuelle est la mémoire de l'environnement textuel interne, construite au cours de la lecture. L'étude porte d'abord sur la mémoire contextuelle explicite, c'est-à-dire les rappels narratifs, qui sont définis d'après leur portée (la distance qui les sépare de leur antécédent). Puis ils sont classés selon l'instance dont ils relèvent dans la fiction : narrateur, héros ou différents personnages. Deux fonctions principales sont assignées aux rappels. L'une, purement temporelle, concerne notamment les expériences de mémoire involontaire. L'autre, herméneutique, consiste à réinterpréter certains événements racontés antérieurement. Une analyse de la « Matinée chez la princesse de Guermantes » permet de décrire le mouvement final de récapitulation et d'élucidation, qui donne lieu à une lecture allégorique rétrospective du roman. La seconde partie porte sur la mémoire implicite du lecteur, en remontant en amont du processus mnémonique, au moment de l'enregistrement des impressions textuelles. Celles-ci sont envisagées à partir de la tradition de Vars memoriae, comme un système de lieux et d'images frappantes qui contribuent à la mémoire des choses et à la mémoire des mots. Sur le même modèle, l'oubli est décrit comme l'effacement des lieux et le déploiement de l'image visuelle de la disparition. Enfin, la mémoire involontaire du lecteur est envisagée à travers l'expérience individuelle de deux lecteurs de Proust, chacun auteur d'une lecture créatrice singulière : Roland Barthes, dans La Chambre claire, et Joseph Czapski, dans Proust contre la déchéanceFormed during the process of reading, contextual memory is the memory of the internal textual environment. The first part of the study focuses on explicit contextual memory, which are narrative recalls. Characterized according to their narrative range (the distance that separates them from their antecedent), these recalls are then classified according to the fictional instances that produce them: the narrator, main or secondary characters. Recalls have two specific functions: one is purely temporal and implies involuntary memory experience; the other is hermeneutic, concerned with the reinterpretation of previously narrated events. An analysis of the "Matinée chez la princesse de Guermantes" describes the final movement of recapitulation and elucidation, which leads to a rétrospective allegorical reading of thé novel. Working backwards to the source of the mnenionic process, which begins while recording textual impressions, the second part of this study explores the reader's implicit memory. These impressions are similar to the-mnemotechnic tradition of the ars memorîae, which is like a System of places and striking visual images that contribute to the memory of things and words. Following this same model, forgetting leads to the fading of places and the unfolding of the visual image of disappearance. The last part of this study considers the reader's involuntary memory through two readers' individual experience with Proust, each one the author of a personal, singular reading: Roland Barthes, in La Chambre Claire (Caméra Lucida) and Joseph Czapski, in Proust contre la déchéance
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Mao, Jessica J. "California's War Over the Bay-Delta: Historic Failures and Current Battles." Scholarship @ Claremont, 2012. http://scholarship.claremont.edu/cmc_theses/482.
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California has one highly-coveted possession: the Bay-Delta, which is the second largest estuary in the United States. Today, tensions are higher than ever as Southern California continues to grow and demand water from the Delta, agriculture suffers from drought and less-than-promised water allocations, and aquatic life diminishes due to environmentally damaging processes like pumping and exporting of water elsewhere. This paper will examine the historic policies that have shaped how the Delta has been managed, their successes and failures, and current plans in discussion for continuing improvement of the Delta. The Bay-Delta Conservation Plan and the Sacramento-San Joaquin Valley Water Reliability Act (HR 1837) are the specific current plans presented and analyzed for potential effectiveness. Despite some of the promising suggestions in HR 1837 and the Bay-Delta Conservation Plan, the Delta will remain a problem in the 21st century until stakeholders from all perspectives compromise enough to enact a single, clear-cut solution.
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Battisti, Anne Marie Gabrielle. "Description of the Dynamic Responses to Hypoxia:Ventilation, Cerebral Blood Flow (CBF), Blood Pressure (BP), and Heart Rate (HR)." Thesis, 2011. http://hdl.handle.net/1807/32916.
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This thesis describes experiments to measure the ventilatory response to hypoxia at a constant (isocapnic) level of CO2 (HVR) in 18 subjects. So as to provide a complete picture of the autonomic responses, middle cerebral artery velocity, a surrogate for cerebral blood flow (CBF), as well as finger plethysmography blood pressure (BP) were also measured. Ventilatory responses have been previously described only in terms of an acute peak followed by a decline. However, rather than a single type of response, I found four types categorized as: Decline, Double, Plateau, or No response. The Double pattern, characterized by a second peak of response was the most common, yet is described here for the first time. These patterns are also characteristic of the CBF and BP responses. Furthermore the temporal correlations between these brainstem-controlled responses are also reported here for the first time.
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Ally, Idrees Abdul Latif. "Comparison of hr-pQCT & MRTA to DXA & QUS for the Ex-vivo Assessment of Bone Strength." Thesis, 2010. http://hdl.handle.net/1807/24527.
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There is a pressing need for better assessment of bone strength as current clinical tools do not directly measure bone mechanical properties, but offer only surrogate measures of bone strength. We conducted an ex-vivo study of emu bones to examine how two investigative devices, hr-pQCT and MRTA, compare to current clinical tools (DXA and QUS) in predicting true bone mechanical properties. We found that hr-pQCT parameters were able to assess bone strength as well as DXA and better than QUS, while MRTA was able to predict bone strength well in low-density but not high-density bones. Our results suggest that both hr-pQCT, which has the unique ability to specifically assess the various determinants of bone strength, and MRTA, which measures a bone mechanical property (stiffness), have great potential for use as clinical tools that can assess various components of bone strength not measured by current devices.
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Morgan, Stacy-Anne. "Structure-based Design and Characterization of Genetically Encoded PhotoactivableE DNA-binding Proteins Based on S. cervisiae GCN4 and Hr. halophila PYP." Thesis, 2010. http://hdl.handle.net/1807/24835.
Full textAbstract:
Halorhodospira halophila photoactive yellow protein (PYP) is a promising candidate to act as a photoswitching domain in engineered proteins due to the structural changes that occur during its photocycle. Absorption of a photon of wavelength 446 nm triggers trans to cis isomerization of its 4-hydroxycinnamic acid chromophore leading to large structural perturbations in the protein, particularly in the N-terminus. In the dark, a slower cis to trans reisomerization of the chromophore restores the protein’s native fold. The fusion of proteins to PYP’s N-terminus may therefore enable photomodulation of the activity of the attached protein.
To test this hypothesis, this thesis descibes genetically encoded photoswitchable DNA-binding proteins that were developed by fusing the prototypical leucine-zipper type DNA-binding protein GCN4 bZIP to the N-terminus of PYP. Five different fusion constructs of full length or truncated GCN4 bZIP and full length PYP as well as fusion constructs of full length GCN4 bZIP and N-terminally truncated PYP mutants were designed in a structure-based approach to determine if the dimerization and DNA binding activities could be controlled by the PYP photocycle.
Extensive biophysical characterization of the fusion constructs in the dark and under blue light irradiation using electronic absorption, circular dichroism and fluorescence spectroscopic techniques were performed. As all the fusion proteins could complete photocycles, the DNA binding abilities of the dark and light-adapted states of the proteins were characterized using spectroscopic techniques as well as by the electrophoretic mobility shift assay. All the fusion constructs maintained DNA-binding abilities, however they each differed in their affinities and the extent to which they were activated by blue light irradiation. The reasons for these differences in DNA-binding abilities and photoactivation are explored. Using the results from the characterization of these constructs, proposals are also made to develop more robust genetically encoded photoactivatable DNA-binding proteins of the same type.
Books on the topic "HR 1817"
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Łazuga, Waldemar. "Rządy polskie" w Austrii: Gabinet Kazimierza hr. Badeniego, 1895-1897. Poznań: Uniwersytet im. Adama Mickiewicza w Poznaniu, 1991.
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Mikietyński, Piotr. Generał Stanisław hr. Szeptycki: Między Habsburgami a Rzecząpospolitą (okres 1867-1918). Kraków: Historia Iagellonica, 1999.
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Lazuga, Waldemar. "Rzady polskie" w Austrii: Gabinet Kazimierza hr. Badeniego, 1895-1897 (Seria Historia). Uniwersytet im. Adama Mickiewicza w Poznaniu, 1991.
Find full textBook chapters on the topic "HR 1817"
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"4. Der Druck im Novellenband Herbstreigen 1897, recte 1896 (Hr)." In Herr Fridolin und sein Glück, 107–24. DE GRUYTER, 1993. http://dx.doi.org/10.1515/9783110932805.107.
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"M 18 a3c ( L 3) e : a2n07L -D 21 , 7 M , e1a9k7i5n . s TL, Taguchi K, Duignan TP, Dhillon KS, Gordon J. Ann Surg 4. Nielsen HJ, Hammer JH, Moesgaard F, Kehlet H. Surgery 105(6):711-719, 1989. 5. B 67 ro 6 w , n19R8 , 2 . Bancewicz J, Hamid J, Tillotson G, Ward C, Irving M. Ann Surg 196(6):672-6. Fernandez LA, MacSween JM, You CK, Gorelick M. Am J Surg 1613:263-270, 1992. 7. H 57 a , m 1 id 98J4 , . Bancewicz J, Brown R, Ward C, Irving MH, Ford WL. Clin Exp Immunol 56:49-8. Tartter PI, Steinberg B, Barron DM, Martinelli G. Arch Surg 122:1264-1268. 1987. 9. J M en o s ll eenr -N LS ie , ls A en ndCe , rsH en anAbJe , rg C -S hr oirse ti nasnesnenF , PHMo , klH an odk la M n . dBP, r J Ju Shul rg CO7 , 9 M :51 ad 3 s -5 en 16G , , 19M 92 o . rtensen J, 10. Fisher E, Lennard V, Siefert P Kluge A, Johannsen R. Human Immunol 3:187-194, 1980. 11. L 10 e1n5n , ar1d9V 83 , . Maassen G, Grosse-Wilde H, Wernet P, Opelz G. Transplant Proc 15(1): 1011-12. F1o9r8d7 . CD, Warnick CT, Sheets S, Quist R, Stevens LE. Transplant Proc 19( 1): 1:456-457, 13. Cox DR. Analysis of binary data, Methuen: London, 1970. 14. Murphy PJ, Connery C, Hicks GL Jr, Blumberg N. J Thoracic Cardiovasc Surgery (in press). 15. A Pa rc tc hheSnu rg Deerlyl in 1g2e3r ( E 1 , 1 ) M : 1i3 ll 2e0r -1 S3D2 , 7 , W1e9r8 tz 8 . MJ, Grypma M, Droppert B and Anderson PA. 16. D 12 e 3 ll : i1n3g2e0r -1 E3P2 , 5 M , 1 il 9 le 8r8 , SD, Wertz MJ, Grypha M, Droppert B, Anderson PA. Arch Surg 17. Dawes LG, Aprahamian C, Condon RE and Malongi MA. Surgery 100:796-803, 1986. 18. Tartter PI. Br J Surg 75:789-792,1988. 19. A Lo gsarAwnagleN le , s , MAuprrpihly1J9G 92 , . Cayten CG, Stahl WM. Presented to the Surgical Infection Society, 20. Truilzi DJ, Vanek K, Ryan DH and Blumberg N. Transfusion (accepted for publication). 21. Murphy P, Heal JM and Blumberg N. Transfusion 31:212-217,1991. 22. Mezrow CK, Berstein I and Tartter PI. Transfusion 32:27-30, 1992. 23. BMuesdch3R2C8 , : 1 H 37 o2p , W 19 C9J3 , . Hoynck van Zpapendrecht MAW, Marquet RL, Jeekel J. N Engl J 24. W 19 a8y7m . ackJP, Warden GD, Miskell P, Gonce S, Alexander JW. World J Surg 11:387-391, 25. WaymackJP, Robb E, Alexander JW. Arch Surg 122:935-939, 1987." In Transfusion Immunology and Medicine, 301. CRC Press, 1995. http://dx.doi.org/10.1201/9781482273441-30.
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