Journal articles: 'HPS-9'

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Colby, Thomas V., Sherif R. Zaki, Richard M. Feddersen, and Kurt B. Nolte. "Hantavirus Pulmonary Syndrome Is Distinguishable From Acute Interstitial Pneumonia." Archives of Pathology & Laboratory Medicine 124, no. 10 (October 1, 2000): 1463–66. http://dx.doi.org/10.5858/2000-124-1463-hpsidf.

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Abstract Context.—Hantavirus pulmonary syndrome (HPS) and acute interstitial pneumonia (AIP) can share similar clinical presentations. AIP is an acute, diffuse lung disease that has some clinical features suggesting a viral infection, although causative agent(s) have not been identified. Objective.—To clinically, histologically, and immunohistochemically compare cases of HPS to cases of AIP and to determine if any cases of AIP were actually examples of HPS. Design.—Seven cases of HPS and 9 cases of AIP were compared clinically and histologically by semiquantitative grading of features in lung tissue. The cases were also evaluated immunohistochemically for the presence of hantaviral antigens. Results.—Hantavirus pulmonary syndrome had a shorter clinical duration and more acute changes histopathologically; AIP was of longer clinical duration and was usually accompanied by histologic evidence of organization. Hantavirus pulmonary syndrome was distinguished by the presence of immature leukocytes in the pulmonary vasculature. No hantaviral antigens were identified immunohistochemically in the 9 case of AIP. Hantaviral antigens were identified in all 7 cases of HPS. Conclusion.—Cases of AIP and fatal cases of HPS can generally be distinguished on clinical and histologic grounds, and this distinction can be further confirmed immunohistochemically.

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Marrero Torres, R., S. Coste-Sibilia, H. Nieves-Jimenez, G. Torres, E. Rivera, and E. A. Torres. "P360 Aggressive Inflammatory Bowel Disease is associated to Hermansky-Pudlak Syndrome: Characterization of a Puerto Rican Cohort." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S379—S380. http://dx.doi.org/10.1093/ecco-jcc/jjab076.484.

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Abstract Background Hermansky-Pudlak Syndrome (HPS), a rare autosomal recessive disorder, is the most common single-gene disorder in Puerto Rico. It is characterized by an aberrant biogenesis of lysosome-related organelles inducing oculocutaneous albinism, bleeding diathesis, and damage to other organs. Around 30% of patients with HPS develop granulomatous enterocolitis, a Crohn’s-like inflammatory bowel disease (IBD). The mutant HPS1 gene is associated with a more severe Early Onset IBD (EO-IBD). We wish to describe a group of patients with HPS-associated IBD. Methods Puerto Ricans with HPS and concomitant IBD were recruited in our IBD clinic for a prospective cohort study. After informed consent, demographic and medical data were collected from the patient and the medical record. Variables included sex, HPS genotype, age at the time of IBD diagnosis, IBD location and behavior according to Montreal and Paris Classification, surgical interventions, medications, and extra-intestinal manifestations (EIM). Descriptive analysis was performed calculating mean and standard deviations. This study is approved by the MSC IRB. Results 13 patients with HPS and IBD, 9 with confirmed genotype 1, were identified: 8 males and 5 females. The mean age at the time of IBD diagnosis was 22 ± 11 years. 6 were diagnosed at ≤ 16 y/o (A1), 6 were diagnosed between 17-40 years (A2) and 1 patient was in the range of EO-IBD (7 y/o). 9 patients had advanced penetrating behavior (B3) of which 7 had concomitant perianal involvement. Most patients (9) had a surgical intervention; 8 have an ostomy. The majority (10) are using biologics (4 with concurrent immunomodulators). The most frequent EIM was peripheral arthropathy seen in 45%. Conclusion HPS patients had a severe course of IBD, as shown by age at diagnosis, phenotype, the prevalence of perianal disease, surgery and use of biologics. In comparison to a database of 836 Puerto Ricans with non HPS Crohn’s Disease, those with HPS were more likely to have surgeries (69% vs 55%, P=.303) and use biologics (77% vs 43%, P=.015). Gastrointestinal symptoms including bleeding may be overlooked by the primary physician. Proactive vigilance in patients with HPS to make an early diagnosis of IBD and aggressive medical treatment may result in better outcomes for these patients.

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Wang, Chun Sheng, Lan Duan, Ming Wei, and Li Xiang Liu. "The Mechanics Behavior Tests of HPS-485W Made in China." Advanced Materials Research 146-147 (October 2010): 1506–9. http://dx.doi.org/10.4028/www.scientific.net/amr.146-147.1506.

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This paper gives a brief introduction of the developmental history of high performance steel (HPS) all over the world. Emphasis of current paper is on the characteristic studies of HPS 485W, which is new structural weathered steel produced by Wuyang Steel Iron Company using quenching and tempering (Q&T) in China. To obtain the strength and ductility of HPS 485W, the tensile coupons were machined from each 8mm, 10mm, 12mm and 14mm thick plate. Based on the static tensile tests in room temperature, major of material mechanical characters were obtained, such as yield strength, ultimate strength, elastic modulus and so forth. Besides, to examine plate toughness, 30 Charpy V-Notch (CVN) specimens from 12mm thick HPS 485W plate were tested from 20 oC to -196 oC . Compared with conventional bridge steels, the CVN test results show that the fracture toughness of HPS 485W is much higher, and the brittle-ductile transition of HPS occurs at a much lower temperature. A set of 9 single-edge bend specimens were took from 20mm and 30mm thick HPS 485W separately for ductility fracture toughness test. The calculated JIC value is 415.8 kJ/m2 for 18mm thick specimen and 507.79 kJ/m2 for 28mm thick specimen, which shows ideal ductility of HPS 485W.

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Maldonado, Enrique F., Francisco J. Fernandez, M. Victoria Trianes, Keith Wesnes, Orlando Petrini, Andrea Zangara, Alfredo Enguix, and Lara Ambrosetti. "Cognitive Performance and Morning Levels of Salivary Cortisol and α-Amylase in Children Reporting High vs. Low Daily Stress Perception." Spanish Journal of Psychology 11, no. 1 (May 2008): 3–15. http://dx.doi.org/10.1017/s1138741600004066.

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The aim of the present study was to assess the effects of daily stress perception on cognitive performance and morning basal salivary cortisol and alpha-amylase levels in healthy children aged 9–12. Participants were classified by whether they had low daily perceived stress (LPS,n= 27) or a high daily perceived stress (HPS,n= 26) using the Children Daily Stress Inventory (CDSI). Salivary cortisol and alpha-amylase were measured at awakening and 30 minutes later. Cognitive performance was assessed using the Cognitive Drug Research assessment system. The HPS group exhibited significantly poorer scores on speed of memory (p < .05) and continuity of attention (p< .05) relative to the LPS group. The HPS group also showed significantly lower morning cortisol levels at awakening and at +30 minutes measures in comparison with the LPS group (p< .05), and mean morning cortisol levels were negatively correlated with speed of memory (p< .05) in the 53 participants. No significant differences were observed between both groups in alpha-amylase levels. These findings suggest that daily perceived stress in children may impoverish cognitive performance via its modulating effects on the HPA axis activity.

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Bin Pet, Mokhtar, and Ahmad Johari Hj Sihes. "Relationship Domain of Form Six Teachers Thinking in Teaching with External Factors of Form Six Teachers." International Journal of Evaluation and Research in Education (IJERE) 4, no. 1 (March 1, 2015): 1. http://dx.doi.org/10.11591/ijere.v4i1.4485.

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<table class="MsoNormalTable" style="width: 444.85pt; border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt; mso-border-insideh: .5pt solid windowtext; mso-border-insidev: .5pt solid windowtext;" border="1" cellspacing="0" cellpadding="0" width="593"><tbody><tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes; mso-yfti-lastrow: yes; height: 63.4pt;"><td style="width: 290.6pt; border: none; border-top: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; height: 63.4pt;" width="387" valign="top">This study aimed to examine the external factors of form six teachers who can influence thinking domain form six teachers in their teaching. This study was conducted using a quantitative approach using questionnaires. A total of 300 form six teacher schools in Johor were chosen as respondents. The findings were obtained as student background factors are the most important factors that influence the thinking domain of form six teachers with a mean value of 4.54 and the domain of thinking is that teachers' expectations domain is the most important with the 4:54. Relation to external factors form six teachers with thinking domain form six teachers in the teaching of significant positive classroom atmosphere factors with r = .524, school goals with r = .405, needs of students with r = .454 and students background with r = .423. This study will help the Ministry of Education to raise the standards of form six education. </td></tr></tbody></table>

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SILVERIO, Americo de Oliveira, Dayanne Cintra GUIMARAES, Larissa Fernanda Queiroz ELIAS, Erika Oliveira MILANEZ, and Silvano NAVES. "ARE THE SPIDER ANGIOMAS SKIN MARKERS OF HEPATOPULMONARY SYNDROME?" Arquivos de Gastroenterologia 50, no. 3 (September 2013): 175–79. http://dx.doi.org/10.1590/s0004-28032013000200031.

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Context Hepatopathies can significantly influence both veins and arteries, these changes may cause some cutaneous stigmas, such as spider angioma (SA) and some systemic vascular changes, such as those observed in hepatopulmonary syndrome (HPS). Based on this common pathophysiological root we can assume that the SA can be skin markers of HPS. Objective The objective of this study is to assess whether there is a relationship between the presence of SA and HPS. Methods Records of 40 patients with liver cirrhosis who underwent contrast echocardiography were evaluated, in which we researched the description of SA, physical examination, and other clinical and laboratory data. For diagnosis of HPS we use these signs of the disease: presence of liver disease (cirrhosis in the case), abnormalities in gas exchange by arterial blood gases, and evidence of pulmonary vasodilations by the contrast echocardiography. Results The SA were found in 21/40 (52.5%) patients and hepatopulmonary syndrome in 9/40 (22.5%). The HPS was observed in 8/21 (38.1%) of patients with SA and 1/19 (5.3%) patients were without this sign (P<0.01). We found no statistically significant difference between the SA and the presence of HPS with sex or age. Patients with SA had a higher hypoxemia [PaO2 84.8 ± 11.5 mmHg and 19.8 ± 14.7 mmHg alveolar-arterial gradient of oxygen (AAG)] than those without SA (PaO2 90.8 ± 10.7 mmHg and 10.9 ± 11.7 AAG mmHg) (P<0.05). Conclusion Our findings show a correlation between the presence of SA and HPS, suggesting that the SA may be cutaneous markers of HPS.

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Johnson, Benny, Smith Giri, Sara E. Nunnery, Eric Wiedower, Omer Jamy, Jason C. Chandler, and Mike G. Martin. "Comorbidities Drive Outcomes for Both Malignancy and Non-Malignancy Associated Hemophagocytic Syndrome." Blood 126, no. 23 (December 3, 2015): 3261. http://dx.doi.org/10.1182/blood.v126.23.3261.3261.

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Abstract Background Secondary hemophagocytic syndrome (HPS), also known as hemophagocytic lymphohistiocytosis (HLH), is a rare syndrome that develops in the context of infection, autoimmune disease or an underlying malignancy. This results in the unregulated activation of the immune system and an aberrant proliferation of histiocytes and hemophagocytosis. Most of what is clinically known about secondary HPS/HLH is from case reports and case series. We studied the predictors of mortality among adults admitted with HPS with or without an associated malignancy using a large national inpatient database. Patients and Methods Cases of HPS were identified from the Nationwide Inpatient Sample (NIS) 2009-2011 using International Classification of Diseases-9th revision Clinical Modification (ICD-9-CM) codes 288.4 for primary or secondary diagnosis combined with bone marrow examination procedure code (41.31). Cases of malignancy were identified by using ICD-9-CM codes 104-208.9 and the use of inpatient chemotherapy was defined by ICD-9-CM procedure codes 9925 and 8607. Comorbidity assessment was done using Deyo modification of Charlson comorbidity index which takes into account 17 ICD based comorbidities. Malignancy was excluded from co-morbidity assessment. The impact of various patient/hospital related factors on mortality was first assessed using chi-square test or Analysis of Variance (ANOVA). Factors with p value 0.01 or less on bivariate analysis were then subjected to multivariate analysis using logistic regression methods. Statistical analysis was done using STATA 13.0 (StataCorp LP, College Station,TX). All p values were two sided and the level of significance was 0.05. Results A total of 276 patient hospitalizations with HPS were identified. Forty-four had an associated malignancy, out of which 38 (86%) were hematologic. The other cases were associated with systemic lupus erythematosus (n=12; 5%), rheumatoid arthritis (n=21; 9%), histoplasmosis (n=3;1.3%) or HIV (n=1; 0.4%). The median age was 42 (range 18-89 years) and 43% (n=114) were females. A total of 66% (n=182) had Charlson index (CI) of 0, whereas 13% (n=27) had a CI of 1 and 21% (n=57) had a CI of 2 or more. On bivariate analysis, the inpatient mortality rate was significantly higher in malignancy associated HPS (OR 2.07; P =0.04), age ≥ 50 (OR 3.46; P <0.01), CI > 2 (OR, 3.04; P <0.01), and patients with Medicare (OR 2.32; P <0.01). However, there was no statistically significant difference in mortality based on the receipt of chemotherapy (P= 0.90), hospital region i.e. rural versus urban (P=0.43) and teaching status (P= 0.71). In multivariate analysis, CI ≥ 2 remained an independent predictor of survival in the overall study cohort (OR 3.52; 95% CI 1.51-8.18; P <0.01). Conclusion In this large series of adults with HPS, patients with malignancy associated HPS, CI ≥ 2, age> 50, and Medicare patients were associated with a worse in-hospital mortality. In multivariate analysis, patients with a greater co-morbidity burden appeared to be the single most important predictor of mortality. This suggests that outcomes for HPS are predicated by the extent of organ dysfunction at diagnosis. Disclosures No relevant conflicts of interest to declare.

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Ohyagi, Hideaki, Nobuyuki Onai, Yong-Mei Guo, Naoto Takahashi, Makoto Hirokawa, Ken-Ichi Sawada, and Toshiaki Ohteki. "Prevention of Hemophagocytosis by TNF-α and IL-6 Blockade in TLR9- and Nod1- Ligand Induced Hemophagocytic Syndrome." Blood 114, no. 22 (November 20, 2009): 1351. http://dx.doi.org/10.1182/blood.v114.22.1351.1351.

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Abstract Abstract 1351 Poster Board I-373 Introduction Hemophagocytic syndrome (HPS, also referred as hemophagocytic lymphohistiocytosis; HLH) is a life-threatening condition caused by hyperinflammatory response. It can be classified into familial and acquired forms. Familial HPS is a disorder inherited in an autosomal recessive or X-linked manner. Several loci and genes have been implicated in the familial HPS, including perforin, or cytotoxic granule exocytosis genes. While, acquired (secondary) HPS is a sporadic syndrome occurring in association with systemic infection (virus, bacteria, protozoa, and fungi), underlying malignancy, or immunodeficient disorder. The central pathophysiologic abnormality in HPS is cytokine dysfunction, resulting in uncontrolled accumulation of activated T-lymphocytes and activated histiocytes (macrophages) in many organs. Several cytokines including interferon-γ, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-10, IL-12, and soluble IL-2 receptor (sCD25), found at extremely high levels in the plasma of HPS patients. Treatment of hemophagocytic lymphohistiocytosis is based on epipodophyllotoxin derivatives, etoposide, corticosteroids, cyclosporin A, antithymocyte globulin (ATG), and, in selected patients, intrathecal methotrexate. Recently, anti-TNF-α therapy has been reported to prove patients with refractory HPS, however, there is not enough evidence. In this study, we established murine HPS model by intravenous injection of CpG oligodeoxynucleotide (ODN)-1668, a ligand for Toll-like receptor 9 (TLR9) and combination of CpG and iE-DAP, which is a ligand for Nod1, and investigated the role of TNF-α and other cytokine in HPS model. Methods C57BL/6J mice were injected intravenously with 200 μg of CpG or combination of CpG and 100 μg of iE-DAP. The treated mice were assayed for temperature, spleen weight, and complete blood count. The serum cytokines levels (TNF-α and IL-6) and triglycerides were determined by ELISA and auto-analyzer, resectively. Hemophagocytosis was determined by flow cytometric (FCM) analysis in the peripheral blood and spleen. The spleen was subjected into immunohistochemistry staining and histological examination. For TNF-α and IL-6 blockade, the mice were treated with TNF receptor (TNFR)-Fc (etanercept) or combination of TNFR-Fc and anti-mouse IL-6 receptor (IL-6R) monoclonal antibody (MR16-1) by intravenous injection. Results CpG injected mouse displayed the typical HPS clinical criteria, such as, fever, cytopenia, splenomegaly, hemophagocytosis in the peripheral blood and spleen. Furthermore, elevations of inflammatory cytokines (TNF-α and IL-6) and triglyceride were detected in the serum of these mice. These clinical symptoms were not observed in CpG-injected TLR2−/−4−/−9−/− mice and LPS-injected wild type mice. Interestingly, combination challenge of CpG and iE-DAP led to synergistic induction of hemophagocytosis and enhanced production of TNF-α and IL-6 in the serum, however, single iE-DAP challenge did not induce HPS. FCM analysis revealed that monocyte-derived dendritic cells, which were CD11b, Ly6c, and F4/80, were mobilized and engulfed TER119+ erythrocyte in the peripheral blood and spleen after these challenge. Treatment of mice with TNFR-Fc partially prevented, and combination of TNFR-Fc and anti IL-6R mAb markedly suppressed hemophagocytosis in the peripheral blood and spleen. Conclusions: Based on these results, CpG or CpG + iE-DAP-induced mouse HPS model is valuable to study for cellular and molecular mechanism of HPS development, and potential system to apply preclinical research. Furthermore, prevention of both TNF-α and IL-6 might represent a novel therapy for HPS. Disclosures No relevant conflicts of interest to declare.

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Gelderman-Fuhrmann, Monique, Xuan Chi, Li Zhi, and Jaroslav Vostal. "UVB Light Exposed Human Platelets Mediate Acute Lung Injury In a Two-Event Mouse Model of Transfusion." Blood 116, no. 21 (November 19, 2010): 3354. http://dx.doi.org/10.1182/blood.v116.21.3354.3354.

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Abstract Abstract 3354 Transfusion related acute lung injury (TRALI) has occurred in patients whose underlying condition led to an inflamed endothelium, and who were transfused with a transfusion product that contained either HLA or HNA antibodies or biologic modifiers such as lipids or antigens from stored cells. Similar two-event reactions can be modeled in animals pretreated with lipopolysaccharide (LPS) and infused with similar types of antibodies or media from stored transfusion products. The first event induces activation of the endothelium and sequestration of neutrophils in the lungs while the second event activates neutrophils to cause local tissue damage. In some animal models of acute lung damage platelet depletion reduces the lung damage while in other models infusion of activated platelets potentiates it. Ultraviolet B (UVB) light has been used on platelet transfusion products to prevent alloimmunization or with chemical sensitizers to reduce pathogens. Such processing may damage platelets and potentiate their storage lesion. UVB exposed human platelets (HPs) were evaluated in a two-event animal model of acute lung injury (ALI) where the sensitizing event was LPS and the second event was infusion of HPs or UVB HPs (2.4 J/cm2). Immunodeficient (SCID) mice were used to minimize the species difference (Piper et al., Transfusion 47:1540-9, 2007). UVB exposure of HPs increased their p-selectin expression (control 17.8±0.3% vs. UVB 35.9±3.2%) and reduced their JC-1 dye ratio indicating mitochondrial damage (8.9±0.7 control vs 1.9±1.2 UVB). Internal organ distribution of intravenous (IV) infused HPs was followed with whole animal imaging, confocal microscopy and with pathophysiological changes in bronchoalveolar lavage fluid (BALF). In LPS-treated mice, UVB HPs labeled with fluorescent dye had more accumulation in lungs compared to untreated HPs (29±12% vs 15±5% respectively; % of total fluorescence recovered), while the accumulation in lungs of healthy animals was equivalent for both UVB treated and untreated HPs. In separate experiments, LPS pretreated mice were infused with UVB exposed HPs or control HPs, and lungs were examined by histology and with confocal microscopy for fluorescent staining for CD41 and CD62 expression. Histology sections revealed extensive changes in lungs, such as thickening of the alveolar septa and obliteration of lung architecture in LPS animals infused with UVB HPs as compared to healthy animals infused with control HPs or with HPs treated with UVB. Confocal microscopy with specific antibodies identified HP accumulation in lungs of LPS treated animals infused with UVB exposed HPs. However, HP accumulation in lungs did not occur with control HPs or in healthy mice. Accumulation of UVB HPs in lungs of LPS pretreated mice was associated with increased (3-4 fold compared to control HPs) protein concentration and leukocyte accumulation in BALF. Increased alveolar permeability to protein and leukocyte accumulation in alveoli is associated with acute lung damage. To examine whether lung damage occurred due to presence of UVB HPs in the lungs or due to biologic mediators released into plasma from UVB exposed HPs we separated plasma from HPs post UVB treatment and infused the UVB plasma alone. Plasma isolated from UVB HPs did not alter BALF protein levels or leukocyte counts even though the UVB HPs did. In conclusion, UVB HPs can accumulate in lungs of LPS primed animals and are associated with lung damage as indicated by histological changes and increased protein and WBCs in BALF fluid. The ALI is associated with direct platelet accumulation in the lungs but not with biologic modifiers released into plasma. Our animal model of ALI suggests that HPs exposed to high doses of UVB could mediate similar effects in patients predisposed to TRALI with sepsis or other causes of endothelial cell inflammation. The findings and conclusions in this abstract have not been formally disseminated by the Food and Drug Administration and should not be construed to represent any Agency determination or policy. Disclosures: No relevant conflicts of interest to declare.

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O’Lone, Emma, Martin Howell, Andrea K. Viecelli, Jonathan C. Craig, Allison Tong, Benedicte Sautenet, William G. Herrington, et al. "Identifying critically important cardiovascular outcomes for trials in hemodialysis: an international survey with patients, caregivers and health professionals." Nephrology Dialysis Transplantation 35, no. 10 (February 10, 2020): 1761–69. http://dx.doi.org/10.1093/ndt/gfaa008.

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Abstract Background Cardiovascular disease (CVD) is a major contributor to morbidity and mortality in people on hemodialysis (HD). Cardiovascular outcomes are reported infrequently and inconsistently across trials in HD. This study aimed to identify the priorities of patients/caregivers and health professionals (HPs) for CVD outcomes to be incorporated into a core outcome set reported in all HD trials. Methods In an international online survey, participants rated the absolute importance of 10 cardiovascular outcomes (derived from a systematic review) on a 9-point Likert scale, with 7–9 being critically important. The relative importance was determined using a best–worst scale. Likert means, medians and proportions and best–worst preference scores were calculated for each outcome. Comments were thematically analyzed. Results Participants included 127 (19%) patients/caregivers and 549 (81%) HPs from 53 countries, of whom 530 (78%) completed the survey in English and 146 (22%) in Chinese. All but one cardiovascular outcome (‘valve replacement’) was rated as critically important (Likert 7–9) by all participants; ‘sudden cardiac death’, ‘heart attack’, ‘stroke’ and ‘heart failure’ were all rated at the top by patients/caregivers (median Likert score 9). Patients/caregivers ranked the same four outcomes as the most important outcomes with mean preference scores of 6.2 (95% confidence interval 4.8–7.5), 5.9 (4.6–7.2), 5.3 (4.0–6.6) and 4.9 (3.6–6.3), respectively. The same four outcomes were ranked most highly by HPs. We identified five themes underpinning the prioritization of outcomes: ‘clinical equipoise and potential for intervention’, ‘specific or attributable to HD’, ‘severity or impact on the quality of life’, ‘strengthen knowledge and education’, and ‘inextricably linked burden and risk’. Conclusions Patients and HPs believe that all cardiovascular outcomes are of critical importance but consistently identify sudden cardiac death, myocardial infarction, stroke and heart failure as the most important outcomes to be measured in all HD trials.

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Bilodid, V. D., and V. V. Stanytsina. "Estimation of the efficiency of thermal energy production by heat pump stations on the basis of heat of low-temperature groundwater according to the methodology of full energy costs." Problems of General Energy 2020, no. 3 (September 24, 2020): 46–52. http://dx.doi.org/10.15407/pge2020.03.046.

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Heat pump station (HPS) as a source of heat supply for district heating system is considered as an alternative to heating boilers on fossil fuels (mainly on natural gas). One of the promising areas of application of powerful HPS, which currently is being studied actively, is their use as consumers-regulators in the control of electrical load in power systems. In this article, we consider groundwater (deep-well water), which lies at a shallow depth and has stable parameters throughout a year, as a source of low-potential heat. On the territory of Ukraine, there are regions with sufficient groundwater reserves that can be used as a source of low-potential heat for HPS. We carried out calculation of the energy consumption for construction, operation and liquidation of HPS on the example of HPS project with an installed heat capacity of 9 MW, consisting of 3 heat pumps with a capacity of 1.9 MW each and a peak gas boiler with a capacity of 3.2 MW, with regard for a typical schedule of heat loads under conditions of Kyiv. The efficiency of such HPS was determined by the method of estimating the total energy costs by comparing the obtained characteristics with similar characteristics of a gas boiler house of the same capacity. We determined energy consumption for the creation of all elements of HPS and its construction: heat pump and other equipment, station building, drilling and arrangement of wells, pipelines, and peak gas boiler. Energy consumption for the creation and operation of an autonomous gas boiler house of the same capacity was calculated. The reduction of energy consumption for the creation of HPS due to the use of polyethylene-propylene pipes instead of steel is determined. The comparison of energy consumption shows that the creation and operation of HPS on deep-well water with a peak boiler house during the first year of operation compensates the energy consumption for its creation and ensures further energy saving. Operation of such HPS with the use of deep-well water will provide an almost fourfold energy saving as compared with an autonomous boiler house. Keywords: energy consumption, comparative analysis, heat pump systems, groundwater, deep-well water, autonomous boiler house, heat supply

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Cho, Young-Keol, Jung-Eun Kim, and Brian T. Foley. "Genetic Analysis of the Full-Length gag Gene from the Earliest Korean Subclade B of HIV-1: An Outbreak among Korean Hemophiliacs." Viruses 11, no. 6 (June 11, 2019): 545. http://dx.doi.org/10.3390/v11060545.

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We determined the earliest full-length HIV-1 gag gene sequences in 110 patients with HIV-1, including 20 hemophiliacs (HPs) and 90 local controls (LCs). The gag gene from stored sera was amplified using RT-PCR, and was subjected to direct sequencing. Phylogenetic analysis indicated that 94 and 16 sequences belonged to the Korean subclade of HIV-1 subtype B (KSB) and subtype B, respectively. A total of 12 signature pattern amino acids were found within the KSB, distinct from the worldwide consensus of subtype B. Within the KSB, the gag gene sequences from donors O and P and those from the 20 HPs comprised two subclusters. In particular, sequences from donor O strongly clustered with those of eight HPs. Moreover, signature pattern analysis indicated that 14 signature nucleotides were shared between the HPs and LCs within KSB (p < 0.01). Among the 14 nucleotides, positions 9 and 5 belonged to clusters O and P, respectively. In conclusion, signature pattern analysis for the gag gene revealed 12 signature pattern residues within the KSB and also confirmed the previous conclusion that the 20 HPs were infected with viruses due to incompletely inactivated clotting factor IX. This study is the first genetic analysis of the HIV-1 gag gene in Korea.

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Heesch, Kristiann C., Erika Hepple, Kaeleen Dingle, and Natasha Freeman. "Establishing and implementing a health promoting school in rural Cambodia." Health Promotion International 35, no. 1 (December 22, 2018): e11-e20. http://dx.doi.org/10.1093/heapro/day114.

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Summary Few studies have used a whole-of-school approach in implementing a health promoting schools (HPS) framework. Descriptions of how HPS is being implemented, particularly in low-resourced, developing countries, are limited. This study used an exploratory case study design to examine the planning and implementation of a HPS in a rural Cambodian village. Data were collected via observations of the school, school documentation, and interviews with stakeholders (n = 9). The data were analysed inductively as an iterative process, from initial coding, through to categorizing, leading to concept mapping and then identifying the emergent themes within the stages of school development and implementation of educational and health programming. The case study demonstrated how all six components of the HPS framework can be used to plan and implement a school in a rural village in a developing country. The key elements of implementation were building local and international partnerships, local leadership, and a culture of change and participation. These elements were used to establish a non-profit school that aimed to address the stated health and educational needs of local villagers. This case study adds to the limited evidence on the HPS components and implementation methods that are being applied in low-resourced, developing countries.

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Randall, Wesley C., and Roberto G. Lopez. "Comparison of Supplemental Lighting from High-pressure Sodium Lamps and Light-emitting Diodes during Bedding Plant Seedling Production." HortScience 49, no. 5 (May 2014): 589–95. http://dx.doi.org/10.21273/hortsci.49.5.589.

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Annual bedding plant seedlings or plugs are considered high quality when they are compact, fully rooted transplants with a large stem caliper and high root dry mass. Greenhouses in northern latitudes rely on supplemental lighting (SL) from high-pressure sodium lamps (HPS) during winter months to achieve high-quality, finished plugs. Light-emitting diodes (LEDs) offer higher energy efficiencies, a long operating life, and precise waveband specificity that can eliminate wavebands not considered useful. Seedlings of Antirrhinum, Catharanthus, Celosia, Impatiens, Pelargonium, Petunia, Tagetes, Salvia, and Viola were grown at 21 °C under a 16-hour photoperiod of ambient solar light and SL of 100 μmol·m−2·s–1 from either HPS lamps or LED arrays with varying proportions (%) of red:blue light (100:0, 85:15, or 70:30). Height of Catharanthus, Celosia, Impatiens, Petunia, Tagetes, Salvia, and Viola was 31%, 29%, 31%, 55%, 20%, 9%, and 35% shorter, respectively, for seedlings grown under the 85:15 red:blue LEDs compared with those grown under HPS lamps. Additionally, stem caliper of Antirrhinum, Pelargonium, and Tagetes was 16%, 8%, and 13% larger, respectively, for seedlings grown under the 85:15 red:blue LEDs compared with seedlings grown under HPS lamps. The quality index (QI), a quantitative measurement of quality, was similar for Antirrhinum, Catharanthus, Impatiens, Pelargonium, and Tagetes grown under LEDs and HPS lamps. However, it was significantly higher for Petunia, Salvia, and Viola under 85:15, 70:30, and 100:0 red:blue LEDs than under HPS lamps, respectively. These results indicate that seedling quality for the majority of the species tested under SL from LEDs providing both red and blue light was similar or higher than those grown under HPS lamps.

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Bykov, Alexey V., Galina N. Demidenko, Linda Zh Nikoshvili, and Lioubov Kiwi-Minsker. "Hyper-Cross-Linked Polystyrene as a Stabilizing Medium for Small Metal Clusters." Molecules 26, no. 17 (August 31, 2021): 5294. http://dx.doi.org/10.3390/molecules26175294.

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Among different polymers nanostructured cross-linked aromatics have the greatest potential as catalytic supports due to their exceptional thermal and chemical stability and preservation of the active phase morphology. This work studies the ability of hyper-cross-linked polystyrene (HPS) to stabilize small Pdn and Ptn (n = 4 or 9) clusters. Unrestricted DFT calculations were carried out for benzene (BZ) adsorption at the BP level of theory using triple-zeta basis sets. The adsorption of BZ rings (stepwise from one to four) was found to result in noticeable gain in energy and stabilization of resulting adsorption complexes. Moreover, the interaction of metal clusters with HPS micropores was also addressed. For the first time, the incorporation of small clusters in the HPS structure was shown to influences its geometry resulting in the stabilization of polymer due to its partial relaxation.

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Arif, Abdulah Bin, Sri Sujiprihati, and Muhamad Syukur. "Pendugaan Heterosis dan Heterobeltiosis pada Enam Genotipe Cabai Menggunakan Analisis Silang Dialel Penuh." Jurnal Hortikultura 22, no. 2 (August 1, 2013): 103. http://dx.doi.org/10.21082/jhort.v22n2.2012.p103-110.

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ABSTRAK Produktivitas cabai di Indonesia sampai saat ini masih rendah. Salah satu cara untuk meningkatkan produktivitas cabai yaitu melalui program pemuliaan tanaman. Terdapat beberapa rancangan persilangan untuk memilih tetua dalam rangka menghasilkan varietas unggul baru, di antaranya rancangan silang dialel. Tujuan penelitian ini ialah memperoleh informasi heterosis dan heterobeltiosis dari persilangan enam tetua cabai serta mendapatkan calon hibrida cabai yang unggul. Penelitian dilakukan pada November 2008-Mei 2009 di Kebun Percobaan Lwikopo IPB. Materi genetik yang digunakan ialah enam tetua cabai (IPB C2, IPB C9, IPB C10, IPB C14, IPB C15 dan IPB C20) serta turunan pertama dari persilangan enam tetua tersebut. Rancangan persilangan yang digunakan yaitu rancangan silang dialel. Hasil penelitian menunjukkan bahwa pada populasi F1 hasil dari persilangan IPB C2 x IPB C10 dan IPB 10 x IPB C2 mempunyai nilai tinggi dikotomous yang relatif lebih tinggi dibandingkan hibrida lainnya. Pada populasi F1 hasil persilangan IPB C2 x IPB C14 dan IPB C14 x IPB C2 mempunyai bobot per buah yang relatif lebih tinggi dibandingkan hibrida lainnya. Nilai heterosis dan heterobeltiosis pada populasi F1 hasil dari persilangan IPB C2 x IPB C10, IPB C2 x IPB C14, IPB C2 x IPB C20, IPB C10 x IPB C2 dan IPB C14 x IPB C2 bernilai positif pada karakter tinggi dikotomous. Nilai heterosis dan heterobeltiosis pada populasi F1 hasil dari persilangan IPB C2 x IPB C14 dan IPB C14 x IPB C2 bernilai positif pada karakter bobot per buah. Calon hibrida yang sesuai dalam program pemuliaan cabai untuk pembentukan varietas unggul ialah populasi F1 hasil dari persilangan IPB C2 x IPB C14 dan IPB C14 x IPB C2.ABSTRACT Abdullah Bin Arif, S. Sujiprihati and M. Syukur. Estimated of Heterosis and Heterobeltiosis in Six Genotypes of Chilli Using Full Diallel Crosses Analysis. Until now productivity of chili in Indonesia is still low. One effort to increase productivity of chilli is by breeding program. There are several cross designs to choose inbred lines to produce new varieties superior, including the design of cross dialel. The aims of this research were to obtain information heterosis and heterobeltiosis from hybrid of six inbred line combination and to gain candidate of hybrids superior. The research was conducted in November 2008-May 2009 at the Garden Experiments Lwikopo IPB. Genetic material used are six inbred lines of chili (IPB C2, IPB C9, IPB C10, IPB C14, IPB C15 and IPB C20) and F1 of the hybridization of combination six inbred lines. The crossing design used was diallel cross. The results showed that population of F1 resulted from crossing of IPB C2 x IPB C10 and IPB 10 x IPB C2 had high dicotomous that was relatively higher than those of other hybrids. The population of F1 obtained from crossing IPB C2 x IPB C14 and IPB C14 x IPB C2 had weight per fruit that was relatively higher than those of other hybrids. Heterosis and heterobeltiosis values in F1 of IPB C2 x IPB C10, IPB C2 x IPB C14, IPB C2 x IPB C20, IPB C10 x IPB C2 and IPB C14 x IPB C2 were positive on high dicotomous character. Heterosis and heterobeltiosis values in F1 IPB C2 x IPB C14 and IPB C14 x IPB C2 were positive on weight per fruit character. The population of F1 that were appropriate used in breeding program to make superior variety were hybrids of IPB C2 x IPB C14 and IPB C14 x IPB C2.

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Sahin, Alpaslan, Victor Willson, and Robert M. Capraro. "Charter School Achievements in Texas: Public versus Charter Schools." International Journal of Educational Reform 27, no. 1 (January 2018): 46–62. http://dx.doi.org/10.1177/105678791802700103.

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This study aimed to investigate the performance of a charter school network, Harmony Public Schools (HPS), in a 3-year longitudinal student-level research study of high school mathematics, reading, and science performance using 2009–2011 Texas Assessment of Knowledge and Skill student data. Propensity-score-matched public (N = 19) and Harmony (N = 11) schools' performances were compared. We conducted a two-level multivariate analysis of covariance on binary outcomes (pass–no pass) for grades 9–11. HPS performed significantly better at grade 9 and worse at grade 11, with no statistical differences at grade 10 in mathematics. Type of school was not significant at either grade 9 or 10 for reading. For science performances, Harmony charter schools performed better at 10th grade and significantly better at 11th grade. Implications of the findings were discussed as to whether charter schools keep their promises of providing quality education.

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Al-Shakarchi, Duraid A., and Huw Morgan. "Properties of the HPS-ICME-CIR Interaction Event of 9-10 September 2011." Journal of Geophysical Research: Space Physics 123, no. 4 (April 2018): 2535–56. http://dx.doi.org/10.1002/2017ja024849.

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Chen, Huiling, Pengyun Zeng, and Dekui Zhang. "Haemophagocytic syndrome triggered by acute lymphoblastic leukaemia with t(9;22)(p24; q11.2)." Journal of International Medical Research 48, no. 2 (September 18, 2019): 030006051987414. http://dx.doi.org/10.1177/0300060519874144.

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Haemophagocytic syndrome (HPS) is a rare and potentially life-threatening condition that requires early diagnosis and prompt combined treatment. This case report describes a male patient with HPS, presenting as acute liver failure, that underwent a thorough evaluation for the cause of his symptoms. A final diagnosis of acute lymphoblastic leukaemia was established more than 2 months after the first presenting symptom appeared. Furthermore, the patient had an unusual chromosomal abnormality with a t(9; 22)(p24; q11.2) translocation, but the reciprocal janus kinase 2-breakpoint cluster region (JAK2-BCR) and BCR-JAK2 fusion transcripts were not be amplified.

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Bennett, Lindsay, and Sharyn Burns. "Implementing health-promoting schools to prevent obesity." Health Education 120, no. 2 (February 3, 2020): 197–216. http://dx.doi.org/10.1108/he-11-2019-0054.

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PurposeObesity in children and adolescents is a significant public health concern. The World Health Organization Health Promoting Schools (HPS) framework promotes good nutrition and physical activity in school settings. While HPS is embraced globally, effective implementation and sustainable programmes are a continued challenge. This paper aims to report on the characteristics of current school interventions based on HPS and implementation barriers and enablers.Design/methodology/approachA literature search identified peer-reviewed studies of school health interventions reflective of the HPS framework focusing on obesity prevention. Studies from all countries were included, if conducted in primary and/or secondary schools; included a sufficient amount of qualitative implementation or process evaluation data to draw conclusions regarding key barriers and enablers to implementation; and were published in English.FindingsNine interventions (n = 9) from seven countries were included. Most were implemented in primary schools and focused on specific grade levels. Engaging parents, the home environment, teacher time constraints, fun interventions, student participation, teacher training, integration with the curriculum and stakeholder engagement all emerged as strong implementation themes. Teachers as role models, establishing community partnerships and policy support also emerged as common themes.Originality/valueFuture interventions may benefit from enhancing teacher and parent health promotion. Partnerships with initiatives focusing on environmental sustainability may simultaneously benefit human and planetary health while strengthening stakeholder engagement opportunities and consistent messaging throughout the community. More comprehensive evaluation data are needed, in particular, for long-term HPS initiatives.

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Grosjean, A., and C. Madelaine-Bonjour. "POS0360-PARE EDUCATIONAL NEEDS AMONG PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTH PROFESSIONALS IN RHEUMATOLOGY: A SWISS CROSS-SECTIONAL QUALITATIVE ANALYSIS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 433. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2343.

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BackgroundThe content and delivery of patient education (PE) should be individually tailored and needs-based for people with inflammatory arthritis1. Therefore, a patient trained in PE joined forces with a rheumatology clinical nurse specialist to explore the needs for the management of patients with RA in a Swiss local context (rheumatology department of a university hospital).ObjectivesTo identify the difficulties and needs of patients with RA regarding their disease and its management in a local context, from both perspectives: patients and health professionals (HPs).MethodsWe developed 2 different semi-structured questionnaires for each surveyed group. They were distributed to 93 patients and 62 HPs during Summer 2020. Only the fully completed surveys were analysed. A qualitative analysis of the answers to the open questions was carried out and the phenomena thus highlighted were then quantified.ResultsWe collected 38 patient (40%) and 35 HP (56%) questionnaires, and 23 patients (25%) and 21 HPs (34%) filled them completely out.Participants among patients were mostly female (74%) with a mean (SD) age of 54,8 (10,9). Mean (SD) number of years of illness after diagnosis was 11,9 (12,6). HPs were nurses (57,1%), medical doctors (19%), occupational therapists (14,3%), physiotherapists (4,8%) and assistant nurses (4,8%).Almost half of HPs (48%) and 39% of patients experience difficulties to talk about sensitive topics like sexuality, financial or emotional difficulties.A third of patients (30%) wished a more supportive attitude from HPs and HPs (62%) would like patients to be more involved in their care, more specifically regarding autonomy and treatment adherence. A few HPs (9%) and patients (19%) want to improve patient-centred and personalised care. Most of HPs (81%) and patients (87%) state that they have no objection or reluctance to PE being developed in the department. Some HPs see PE as an additional workload (19%) and others as a tool to involve the patients more in their care (43%).HPs (43%) express a need for patient’s and disease’s management training and wish to acquire additional tools and methods to better assist their patients (43%). A third of them (33%) report a lack of communication, collaboration and interdisciplinarity to support patients. Furthermore, due to the lack of time and availability, 67% of them are not able to provide adequate time for meeting the patients’ needs. Some HPs feel powerless to help their patients (19%). Some others (18%) highlight the difference of perspectives and concerns between patients and HPs.Patients and HPs agreed on most of the main difficulties related to the disease and follow-up. It should be noted that HPs were not aware of the difficulties related to their patients’ sleep. The painful and distressing psychological and emotional impact of RA is the difficulty most cited by patients (74%) and the second most mentioned by HPs. More than half of patients (61%) have difficulty managing their pain.ConclusionThe results of this study confirm the need for PE in the department. Communication is a challenge for both populations. HPs know their patients well, but patients and HPs have different expectations regarding disease’s management and follow-up. This work shows the importance of analysing educational needs: it brings out dimensions of the disease and its management that are sometimes hidden or underinvestigated. It thus helps to have a better understanding of the reality and difficulties as they are experienced by people in order to propose appropriate solutions. This work provides a basis for reflection and discussion for the future development and implementation of a PE program, based on the paradigm of the patient-HP partnership. In addition to being an example of an advanced and successful patient-HP partnership, it also demonstrates the benefits of such collaboration.References[1]Zangi HA, Ndosi M, Adams J, et al. EULAR recommendations for patient education for people with inflammatory arthritis Annals of the Rheumatic Diseases 2015;74:954-962.Disclosure of InterestsNone declared

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Moka, Nagabhishek, Dong Chen, Chen Han, Kevin J. O'Brien, Sara Haroutinian, Laryssa Huryn, Wendy Introne, et al. "Novel Hermanksky-Pudlak Syndrome Type 6 Missense Variant Associated with Subclinical Oculocutaneous Albinism and Mild Bleeding." Blood 132, Supplement 1 (November 29, 2018): 1153. http://dx.doi.org/10.1182/blood-2018-99-109829.

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Abstract Qualitative disorders of platelets are often missed at clinical evaluation. Hermansky-Pudlak (HPS) syndrome is a rare genetic metabolic disorder with subtype specific clinical associations most prevalent in Puerto Rico with strong link to consanguinity. HPS is usually associated with albinism, visual impairment and a qualitative platelet dysfunction due to absence of dense granules. Ceroid accumulation can be associated with inflammatory bowel disease, pulmonary fibrosis and kidney disease. Ten variants have been described with types 1, 2 and 4 associated with severe disease whilst type 3, 5 and 6 is associated with mild disease. Little is known about types 7, 8, 9 and 10. A Caucasian adult female presented with a history of intermittent episodes of severe bleeding. She carried the diagnosis of probable von Willebrand's disease at presentation. This particular patient did not respond to cryoprecipitate infusion but bleeding stopped secondary to infusion of normal platelets, a clue to a platelet storage disorder. Hence she was re-investigated for a bleeding disorder and initial coagulation testing identified abnormal platelet aggregation and amplitude pattern to epinephrine. She was subsequently evaluated with platelet transmission electron microscopy and platelet flow cytometry at the Mayo Clinic Hematopathology. Platelet TEM showed complete absence of dense granules and a normal flow cytometry. HPS was suspected and initial genetic studies identified a variant genetic abnormality. Further studies were done at the NIH. Classical clinical features of HPS like nystagmus, and ocular albinism was not identified at initial neurological and ophthalmologic examination. But more detailed evaluation revealed subclinical oculocutaneous albinism. Genome wide SNP analysis showed regions of homozygosity including HPS 1 and HPS 6; deletions were not identified in these genes. Full length HPS1 transcript was amplified by PCR of genomic DNA. Targeted next-generation sequencing identified a novel homozygous missense variant [c.383T>C (p.V128A)] in HPS6. Reduced HPS6 mRNA levels were found in the patient's skin fibroblasts compared to cells from patients with HPS-1 and normal control cells. HPS6 protein expression in the patient's cells was also low and approximately 60% lower than that of normal cells. HPS is a rare platelet storage disorder that can often be missed. Platelet aggregation tests need to be followed up by platelet TEM and genetic testing to definitively diagnose this condition. Further work up has defined a new missense variant by SNP analysis, next generation sequencing and fibroblast culture. It is important to identify the subtype of HPS, because certain subtypes of HPS (HPS 1, 2 and 4) have clinical manifestations like progressive pulmonary fibrosis. Identification of the platelet storage disorder also helps in management of the bleeding diathesis. Disclosures No relevant conflicts of interest to declare.

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Inoue, Mariko, and Kazue Yamaoka. "Social Factors Associated With Psychological Distress and Health Problems Among Elderly Members of a Disaster-Affected Population: Subgroup Analysis of a 1-Year Post-disaster Survey in Ishinomaki Area, Japan." Disaster Medicine and Public Health Preparedness 11, no. 1 (November 15, 2016): 64–71. http://dx.doi.org/10.1017/dmp.2016.147.

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AbstractObjectiveWe aimed to investigate the influence of social factors, especially social support, on psychological distress and the prevalence of health problems (HPs) among victims living in their homes 14 to 21 months after the Great East Japan Earthquake and tsunami.MethodsA subgroup analysis was performed for elderly participants of a cross-sectional household survey in Ishinomaki area, Japan. The prevalence of psychological HPs was assessed by using a psychological distress questionnaire (K6) and by recording the number of subjective HPs. Perceived social support was assessed in 3 dimensions: informational, emotional, and instrumental support. Univariate and multivariate logistic regression models were used to examine the association between social factors and psychological health.ResultsAn elderly subgroup with 879 participants was used for analyses. Psychological distress (K6 score≥9) was observed in 6.8% of the participants aged 65 to 74 years and in 8.0% of those aged ≥75 years. Receiving a long-term care service was associated with having HPs, and discontinuation of attendance at a hospital as an outpatient was associated with psychological distress. Receiving emotional support was associated with lower psychological distress and not having HPs.ConclusionsEmotional support was found to be an important factor for promoting health among elderly disaster victims. (Disaster Med Public Health Preparedness. 2017;11:64–71)

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Zhi, Li, Xuan Chi, Monique Gelderman-Fuhrmann, and Jaroslav Vostal. "Protein Kinase C Mediates UVB Light Induced Changes In Human Platelets that Lead to Inflammation In a Two-Event Animal Model of Transfusion Mediated Acute Lung Injury." Blood 116, no. 21 (November 19, 2010): 3358. http://dx.doi.org/10.1182/blood.v116.21.3358.3358.

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Abstract Abstract 3358 Pathophysiology of acute lung injury (ALI) includes an inflammatory component with recruitment and activation of neutrophils to the lungs. One proposed mechanism of transfusion related acute lung injury (TRALI) involves two events; the first is a generalized inflammatory response, as would occur in sepsis, which leads to activation of endothelial cells and sequestration of neutrophils to the lungs. The second is an infusion of a transfusion product that contains HLA or HNA antibodies or biologic modifiers such as lipids from stored cells. The second event activates the neutrophils sequestered in the lungs which lead to neutrophil degranulation, superoxide release and localized tissue damage. Growing evidence suggests that platelets exert proinflammatory actions which include supporting tissue infiltration of neutrophils in septic lung injury. In a separate 2010 ASH abstract we show that ultraviolet B light (UVB, 2.4 J/cm2) exposed human platelets (HPs) mediate lung injury in a two-event animal model of ALI. UVB exposure has been reported to activate platelet protein kinase C (PKC). We compared the effects of UVB exposure to PKC activation by a PKC agonist, PMA (30 nM), in aggregation, activation and potential to cause lung injury in the two-event animal model. HPs were collected by apheresis and stored overnight with experiments performed on day 1 post collection. Platelet aggregation induced by increasing concentrations of ADP (5-20 mM) was potentiated by pretreatment with UVB or PMA. TRAP (20 mM) induced aggregation was inhibited by UVB, but unchanged by PMA pretreatment. Both UVB and PMA increased platelet PAC-1 binding and p-selectin expression. Pretreating HPs with a PKC inhibitor prevented all of PMA induced PAC-1 binding and inhibited UVB induced PAC-1 binding by 40%. Furthermore, the PKC inhibitor partially reduced p-selectin expression on PMA and UVB treated HPs, whereas p-selectin expression on control HPs remained unchanged. The UVB HPs or PMA HPs were evaluated in the two-event animal model of ALI. Immunodeficient (SCID) mice were used to minimize the species difference (Piper et al., Transfusion 47:1540-9, 2007). MIP-2 elevation in plasma is a marker of acute inflammation and was increased following LPS administration. Infusion of control HPs as the second event moderately increased MIP-2. When UVB HPs or PMA HPs were infused MIP-2 was significantly elevated compared to control HPs. Pretreatment of UVB HPs with the PKC inhibitor (RO31-8425) reduced MIP-2 elevation to the level of control platelets. In summary, UVB HPs can cause ALI in animals pretreated with LPS (separate 2010 ASH abstract as mentioned above). Changes to the platelets induced by UVB appear to be mediated by PKC since a PKC agonist (PMA) has similar effects on platelets in aggregation and activation as does UVB and PKC inhibitor partially inhibits UVB induced platelet activation. In vivo, both UVB and PMA treated HPs elevated MIP-2 plasma levels when injected after LPS and this response was prevented by treatment of platelets with a PKC inhibitor prior to UVB exposure. The UVB induced activation leads to a conformational change in GpIIb/IIIa which potentiates weak agonist induced aggregation and mediates an acute in vivo inflammatory response that may be responsible for the acute lung injury in the animal model. Understanding the underlying mechanisms of UVB exposure induced changes in platelets would be beneficial in designing methods to reduce the UVB associated ALI in an animal model and potentially in patients susceptible to TRALI by a primary sensitizing event and infused with high dose UVB exposed platelets. The findings and conclusions in this abstract have not been formally disseminated by the Food and Drug Administration and should not be construed to represent any Agency determination or policy. Disclosures: No relevant conflicts of interest to declare.

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Magagnini, Gianmaria, Gianpaolo Grassi, and Stiina Kotiranta. "The Effect of Light Spectrum on the Morphology and Cannabinoid Content of Cannabis sativa L." Medical Cannabis and Cannabinoids 1, no. 1 (June 12, 2018): 19–27. http://dx.doi.org/10.1159/000489030.

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Cannabis sativa L. flowers are the main source of Δ-9-tetrahydrocannabinol (THC) used in medicine. One of the most important growth factors in cannabis cultivation is light; light quality, light intensity, and photoperiod play a big role in a successful growth protocol. The aim of the present study was to examine the effect of 3 different light sources on morphology and cannabinoid production. Cannabis clones were grown under 3 different light spectra, namely high-pressure sodium (HPS), AP673L (LED), and NS1 (LED). Light intensity was set to ∼450 µmol/m2/s measured from the canopy top. The photoperiod was 18L: 6D/21 days during the vegetative phase and 12L: 12D/46 days during the generative phase, respectively. At the end of the experiment, plant dry weight partition, plant height, and cannabinoid content (THC, cannabidiol [CBD], tetrahydrocannabivarin [THCV], cannabigerol [CBG]) were measured under different light treatments. The experiment was repeated twice. The 3 light treatments (HPS, NS1, AP673L) resulted in differences in cannabis plant morphology and in cannabinoid content, but not in total yield of cannabinoids. Plants under HPS treatment were taller and had more flower dry weight than those under treatments AP673L and NS1. Treatment NS1 had the highest CBG content. Treatments NS1 and AP673L had higher CBD and THC concentrations than the HPS treatment. Results were similar between experiments 1 and 2. Our results show that the plant morphology can be manipulated with the light spectrum. Furthermore, it is possible to affect the accumulation of different cannabinoids to increase the potential of medicinal grade cannabis. In conclusion, an optimized light spectrum improves the value and quality of cannabis. Current LED technology showed significant differences in growth habit and cannabinoid profile compared to the traditional HPS light source. Finally, no difference of flowering time was observed under different R:FR (i.e., the ratio between red and far-red light).

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Soler-Rosario, Yadira, Nilka J. Barrios, Ricardo Garcia, Alicia Fernandez-Sein, and Enid Rivera. "Dengue Virus Associated Hemophagocytic Syndrome with Neurogical Manifestations in Children: A Case Report." Blood 114, no. 22 (November 20, 2009): 4516. http://dx.doi.org/10.1182/blood.v114.22.4516.4516.

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Abstract Abstract 4516 Dengue fever, caused by dengue virus, can cause increased vascular permeability, which leads to a bleeding diathesis or disseminated intravascular coagulation known as Dengue Hemorrhagic Fever (DHF). Hemophagocytocytic Syndrome (HPS) with neurological manifestations is an uncommon presentation of DHF. There are no reports of virus associated with HPS and neurological manifestations in the pediatric literature. Hemophagocytic Syndrome (HPS) is a clinico-pathologic entity characterized by proliferation of T lymphocytes and macrophages leading to cytokine overproduction. HPS may be diagnosed in association with malignant, genetic, or autoimmune diseases. Dengue virus is considered non-neurotropic, however neuroinvansion has been reported. We present the case of a 10 month old female patient who developed DHF, manifested with upper GI bleeding, hypotension and pancytopenia. The infant subsequently developed dengue shock syndrome, with thrombocytopenia, intravascular hemolysis, coagulopathy, elevated transaminase, hyperbilirubinemia, and creatine kinase (CK) of 2,876U/L. She required artificial hemodynamic and blood components support. During her course of illness, she developed ecchymosed, purpuric bullae lesions of the skin in the distal upper extremities. Her IgM ELISA for Dengue virus was positive. Bone marrow aspiration and biopsy was diagnostic for HPS. The patient was initiated on IV steroids and antibiotics therapy. An improvement was noticed on day 8 of illness and was weaned off completely of all artificial support by the day 9. A complete recovery of her hematological, transaminase, billirubin, and coagulation parameters was noticed on day 12. A repeated bone marrow aspirate and biopsy examination was normal. Patient's recovery was significant by muscle weakness (MCG grade ≤3), hypotonia, reduced tendon reflex and increased CK suggestive of possible myositis. The cerebrospinal fluid and magnetic resonance imaging studies of the brain were normal. She was given IV immunoglobulin (500mg/kg) for 2 consecutive days with remarkable neurological improvement including a normal CK (56U/L).She was weaned of steroids completely on day 20.Dengue virus infection was confirmed by a positive serology result at the convalescent stage. On day 23 she had a complete clinical recovery. To our knowledge, this is the first case reported of dengue virus-associated HPS and neurological manifestations in a pediatric patient with DHF. Clinicians should consider that the occurrence of HPS and neurological manifestations in children could de due to dengue virus infection. Disclosures: No relevant conflicts of interest to declare.

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Healy, Will, and David Graper. "PETUNIA SEEDLING GROWTH - FLOWERING RESPONSE." HortScience 25, no. 9 (September 1990): 1103a—1103. http://dx.doi.org/10.21273/hortsci.25.9.1103a.

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Petunia `Red Flash' seedlings were grown under HPS (175 μmol m-2 s-1) photoperiod treatments of 10, 12, 14 or 16 hr at 20C soil temperature in a shaded glasshouse where the maximum peak PPF was reduced to 150 μmolm-2s-1. Seedling were transplanted after they had unfolded a specific number of leaves and grown under natural days or placed under photoperiod treatments which consisted of an 8 hr natural day with incandescent day extension treatments of 1 to 6 hours.A 16 hr HPS treatment decreased the days to transplant (DTT) by more than 4 days and reduced the days from transplant to flower (DTF) by more than 5 days. The total reduction in days from sowing to flower (DSTF) was at least 8 days. When compared to unlighted controls, the reduction in DSTF was 26 days. The longer the seedlings remained under the HPS treatments, the shorter the DTF and DSTF. Premature shifting of plants to natural days resulted in up to a 9 day delay in DSTF. At photoperiods greater than 13 hr, the number of nodes subtending the inflorescence becomes constant regardless of number of leaves at transplant.

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CHU, Xiuli, Xianyou LUO, and Zhichun ZHOU. "Exponential fertilization on red-seed tree (Ormosia hosiei) seedlings subjected to contrasting light conditions: Do we really need intensive nutrient loading?" Notulae Botanicae Horti Agrobotanici Cluj-Napoca 49, no. 2 (April 29, 2021): 12244. http://dx.doi.org/10.15835/nbha49212244.

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Exponential fertilization (EF) can feed seedlings with more nutrients than needed for growth and continuous lighting is expected to reduce the risk of loading at high application rate. In this study, red-seed tree (Ormosia hosiei Hemsley & E. H. Wilson) seedlings were raised by EF at a low rate of 160 mg nitrogen (N) plant-1 (conventional) (N-phosphorus [P]-potassium [K], 12-9-12) and a high rate of 600 mg N plant-1 (intensive), which was adapted from previous studies with large-pot-seedlings. Both fertilizer regimes were nested to either of two light spectra from high-pressure sodium (HPS) and light-emitting diode (LED) sources with three replicates for each combined treatment. Seedlings subjected to the conventional regime in the LED spectrum showed better growth and greater biomass accumulation with higher leaf N and P contents than other ones. In the conventional fertilizer regime, the LED spectrum also resulted in higher photosynthesis shown by more pigments and higher N synthesis than the HPS spectrum. The HPS spectrum strengthened P synthesis in the intensive regime. The antioxidative activity was stimulated by a high dose of EF, hence excessive toxicity was likely induced. We recommend using the normal rate of 160 mg N plant-1 for the culture of red-seed tree seedlings with LED lighting to promote seedling quality without causing excessive nutrient toxicity.

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Cazzador, Diego, Daniele Borsetto, Enrico Alexandre, Chiara Pavone, Domenico d'Avella, Antonio Mazzoni, and Elisabetta Zanoletti. "Hearing Preservation Surgery via Retrosigmoid Approach with Retrolabyrinthine Meatotomy in Small Vestibular Schwannoma." Journal of Neurological Surgery Part B: Skull Base 80, S 03 (February 28, 2019): S281—S283. http://dx.doi.org/10.1055/s-0039-1677847.

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Objectives Vestibular schwannomas (VS) extending into the internal auditory canal (IAC) are currently considered as an unfavorable condition for hearing preservation surgery (HPS) via retrosigmoid (RS) approach due to the poor direct visualization of the facial and cochlear nerves course through the IAC and the fundus during microsurgery. Design The operative steps are described in a surgical instructional video. Setting The surgery took place at a tertiary-care center. Participants Patient is a 45-year-old man who was incidentally diagnosed with an extrameatal VS extending for 9 mm into the left cerebellopontine angle (CPA). Hearing function at diagnoses was excellent, with pure tone average (PTA) = 15 dB and speech discrimination score (SDS) = 100% (class A according to the Tokyo classification) and minimal impairments on auditory brainstem response (ABR). Given these preoperative features in small VS, hearing was the main function to look into in the treatment planning. Initial observation or HPS were proposed. Results The patient underwent surgical excision for HPS via RS approach combined with retrolabyrinthine meatotomy (RLM). RLM enables the complete exposure of the IAC to the fundus, after drilling the bony surface of the posterior IAC wall, under guidance of the anatomical landmarks, namely, the endolymphatic duct, the blue lines of the posterior, and superior semicircular canals, and common crus. Nor intra-, neither postoperative complications occurred. Histologic examination confirmed the diagnosis of VS. A 3-month short-term follow-up revealed a class B hearing function with PTA = 30 dB, SDS = 100%, and normal facial nerve status. Conclusions RLM via RS approach proved to be effective for HPS, enabling the full course of the facial and cochlear nerves through the IAC to be directly exposed.The link to the video can be found at: https://youtu.be/KC1S4pxpLCk.

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Szymanski, Pawel, and Dariusz Mikielewicz. "Additive Manufacturing as a Solution to Challenges Associated with Heat Pipe Production." Materials 15, no. 4 (February 21, 2022): 1609. http://dx.doi.org/10.3390/ma15041609.

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The aim of this review is to present the recent developments in heat pipe production, which respond to the current technical problems related to the wide implementation of this technology. A novel approach in HP manufacturing is to utilise hi-tech additive manufacturing techniques where the most complicated geometries are fabricated layer-by-layer directly from a digital file. This technology might be a solution to various challenges that exist in HP production, i.e., (1) manufacturing of complex or unusual geometries HPs; (2) manufacturing complicated and efficient homogenous wick structures with desired porosity, uniform pore sizes, permeability, thickness and where the pores are evenly distributed; (3) manufacturing a gravity friendly wick structures; (4) high customisation and production time; (5) high costs; (6) difficulties in the integration of the HP into a unit chassis that enables direct thermal management of heated element and decrease its total thermal resistance; (7) high weight and material use of the part; (8) difficulties in sealing; (9) deformation of the flat shape HPs caused by the high pressure and uneven distribution of stress in the casing, among others.

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Poel, Brian R., and Erik S. Runkle. "Spectral Effects of Supplemental Greenhouse Radiation on Growth and Flowering of Annual Bedding Plants and Vegetable Transplants." HortScience 52, no. 9 (September 2017): 1221–28. http://dx.doi.org/10.21273/hortsci12135-17.

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Supplemental radiation (SR), traditionally provided by high-pressure sodium (HPS) lamps, is recommended for greenhouse production of seedlings during radiation-limiting conditions. Light-emitting diodes (LEDs) have emerged as an appealing alternative to HPS lamps primarily because they can provide SR at improved energy efficiencies, they have longer fixture lifetimes, and the radiation spectrum can be tailored to potentially manipulate plant morphology by targeting radiation absorption of specific photoreceptors. We grew seedlings of three annual bedding plants and two vegetable transplants in greenhouses at 20 °C under a 16-h photoperiod under six SR treatments: five that delivered a photosynthetic photon flux density (PPFD) of 90 μmol·m−2·s–1 from HPS lamps (HPS90) or LEDs [four treatments composed of blue (B; 400–500 nm), red (R; 600–700 nm), far red (FR; 700–800 nm), and/or white LEDs] and one that delivered 10 μmol·m−2·s–1 from HPS (HPS10) lamps as a control with matching photoperiod. The LED treatments, defined by the percentages of B, green (G; 500–600 nm), and R radiation, were B10R90, B45R55, B10G5R85, and B12G20R68 + FR (FR at 12 μmol·m−2·s–1). At transplant, leaf area and seedling height were similar among 90 μmol·m−2·s–1 treatments in all species except snapdragon (Antirrhinum majus), in which seedlings grown under B12G20R68 + FR had 62% greater leaf area than those grown under B45R55 and were 47%, 18%, 38%, and 62% taller than those grown under HPS90, B10R90, B10G5R85, and B45R55, respectively. After transplant and finishing under the same SR treatments, snapdragon flowered on average 7 days earlier under the B12G20R68 + FR treatment than the other LED treatments, whereas geranium (Pelargonium ×hortorum) grown under B45R55 and B12G20R68 + FR flowered 7 to 9 days earlier than those under the B10G5R85 and B10R90 treatments. Seedlings of each species grown under the HPS10 treatment accumulated less dry weight and took longer to flower compared with seedlings under the other SR treatments. We conclude that radiation quality of SR has relatively little effect on seedling growth and subsequent flowering although in some crops, flowering may be earlier when SR includes FR radiation.

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Whitman, Catherine, Royal Heins, Arthur Cameron, and William Carlson. "Effects of Temperature, Photoperiod, and Light Quality on Flowering in Several Herbaceous Perennial Species." HortScience 30, no. 4 (July 1995): 771D—771. http://dx.doi.org/10.21273/hortsci.30.4.771d.

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The influence of low temperatures on Campanula carpatica `Blue Clips' and Lavandula angustifolia `Munstead' flowering was determined; plants were stored at 5C for several weeks and forced under 9-h photoperiods with a 4-h night interruption (NI). C. carpatica, L. angustifolia, and Asclepias tuberosa were forced under NI at five temperatures (15–27C) and time to flower under each treatment was calculated. Flower number and size were reduced at highest temperatures. The effectiveness of cool-white fluorescent (CWF), high-pressure sodium (HPS), incandescent (I), and metal halide (MH) lights in inducing flowering in C. carpatica and Coreopsis lanceolata `Early Sunrise' was compared. Lighting was delivered as a 7-h daylength extension with PPF ranging from 0.05–2.0 μmol·m–2·s–1. Minimum irradiances above which all C. carpatica flowered were approximately 0.14, 0.12, 0.1, and 0.17 μmol·m–2·s–1, respectively. C. lanceolata under CWF displayed irregular flowering throughout the range of intensities used. Under HPS and MH, minimum irradiances for 100% flowering were 0.37 and 1.0 μmol·m–2·s–1, respectively, with sporadic flowering at lower intensities. Under I light, all C. lanceolata exposed to 0.12 μmol·m–2·s–1 or more flowered.

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Martı´nez, Jose´ Marı´a Rico, and Joseph Duffy. "Forward and Inverse Acceleration Analyses of In-Parallel Manipulators." Journal of Mechanical Design 122, no. 3 (May 1, 1998): 299–303. http://dx.doi.org/10.1115/1.1288360.

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Simple expressions for the forward and inverse acceleration analyses of a six degree of freedom in-parallel manipulator are derived. The expressions are obtained by firstly computing the “accelerator” for a single Hooke-Prismatic-Spheric, HPS for short, connector chain in terms of the joint velocities and accelerations. The accelerator is a function of the line coordinates of the joint axes and of a sequence of Lie products of the same line coordinates. A simple expression for the acceleration of the prismatic actuator is obtained by forming the Klein form, or reciprocal product, with the accelerator and the coordinates of the line of the connector chain. Since the Klein form is invariant, the resulting expression can be applied directly to the six HPS connector chains of an in-parallel manipulator. As a required intermediate step, this contribution also derives the corresponding solutions for the forward and inverse velocity analyses. The authors believe that this simple method has applications in the dynamics and control of these in-parallel manipulators where the computing time must be minimized to improve the behavior of parallel manipulators. [S1050-0472(00)01303-9]

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Mourad, Michelle, Sumant Ranji, and Diane Sliwka. "A Randomized Controlled Trial of the Impact of a Teaching Procedure Service on the Training of Internal Medicine Residents." Journal of Graduate Medical Education 4, no. 2 (June 1, 2012): 170–75. http://dx.doi.org/10.4300/jgme-d-11-00136.1.

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Abstract Introduction Academic medical centers must provide safe inpatient procedures while balancing resident autonomy and education. We performed a randomized, controlled trial to evaluate the effect of a 2-week hospitalist procedure service (HPS) rotation on interns' self-perceived procedure ability, knowledge, and autonomy versus the standard curriculum. Methods We randomly selected 16 of 57 internal medicine interns (28%) to participate in the intervention group rotation, with 29 interns in the control group. All interns were surveyed before the start of residency and at the end of the postgraduate year-1 (PGY-1) and PGY-2 years to evaluate self-reported knowledge and ability to (1) safely perform procedures, (2) supervise procedures, and (3) use bedside ultrasound. Results Ninety-four percent of HPS interns (15/16) and 71% of control interns (29/41) completed all surveys. Baseline knowledge and experience did not differ significantly between the groups. The intervention group performed significantly more paracentesis (9 versus 4; P < .001), thoracentesis (6 versus 2; P < .001), and lumbar puncture (4 versus 3; P < .001) procedures than did the control group. After their first year, residents who completed the HPS rotation rated their ability to safely perform and supervise all of the assessed procedures as higher (P < .05 for all procedures) and were more likely to rate self-perceived knowledge as very good or excellent in all surveyed aspects of procedure performance (P < .05). Discussion A 2-week hospitalist-supervised procedure service rotation substantially improved residents' experience, confidence, and knowledge in performing bedside procedures early in their training, with this effect sustained through the PGY-2 year. Standardized procedure service rotations are a viable solution for programs seeking to improve their procedure-based education.

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Chen, Xiaochen, Wu Depei, Aining Sun, Huiying Qiu, Xiaojin Wu, and Xiaolan Shi. "Subcutaneous Panniculitis-Like T-Cell Lymphoma: A Study of 12 Cases." Blood 118, no. 21 (November 18, 2011): 5217. http://dx.doi.org/10.1182/blood.v118.21.5217.5217.

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Abstract Abstract 5217 Objective: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare and distinct type of T-cell lymphoma. The objective of this study was to explore the clinical presentation, treatment, and prognosis of patients with SPTCL. Methods: Twelve cases of SCPTCL, treated in our hospital between June 2005 and June 2010, were included in this study. Their clinicopathological data were reviewed and analyzed retrospectively. Results: The median age at diagnosis was 41 years (range 25–69 years) and 7 (58%) were women. 9 cases had a CD3+, CD4-, CD8- phenotype; 2 cases, a CD3+, CD4-, CD8+ phenotype; and 1 case, a CD3+, CD4+, CD8- T-cell phenotype. In all cases, strong expression of cytotoxic proteins (granzyme B, TIA-1, perforin) was observed. CD56 was expressed in 8 of 12 cases. 4 patients had presented with solitary or localized skin lesions. Ulceration was observed in 3 patients. B symptoms, such as fever, chills, night sweats, and weight loss, had been recorded in 7 of 12 patients. Laboratory abnormalities, mainly anemia, leucopenia, thrombocytopenia or combined cytopenias, and elevated liver function tests and lactate dehydrogenase, were reported in 4 patients. Bone marrow examination showed histiocytic hyperplasia, hemophagocytosis, or decreased cellularity in 3 cases, but no evidence of lymphoma. A HPS was diagnosed in 4 of 12 patients (33%), and was fatal in 2 of them. Four patients presenting with solitary or localized skin lesions had been treated with radiotherapy (2 cases) or surgery (2 cases). All 4 patients reached complete remission and only 1 of them showed a skin relapse, which was treated successfully with radiotherapy again. Eight patients with diffused lesions were treated with chemotherapy (CHOP or CHOP-like courses). After initial treatment 5 (63%) of 8 patients had developed new skin lesions, and 2 of them had developed extracutaneous localizations. Then the 3 of the relapsed patients were treated with autologous stem cell transplantation, all of whom obtained complete remission. At the time of last follow-up (median follow-up: 34 months; range: 10–60 months), 5 patients are in complete remission, 4 patients have ongoing skin disease, while 3 patients have died, 2 of the complications of HPS or therapy-related side effects and 1 of unrelated disease. The 3-year OS and DSS of the patients were 75% and 42%, respectively. Patients without HPS had a significantly better 3-year OS (88%) than patients with HPS (50%; P <.001). Conclusion: SPTCL seems to be a kind of heterogeneity disease. The factors associated with an unfavorable disease course were: diffuse lesions, a low white blood cell count, elevated lactate dehydrogenase, and combine with HPS. Autologous stem cell transplantation may improve the overall survival of high risk patients. Disclosures: No relevant conflicts of interest to declare.

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Warner, Ryan M. "Temperature and Photoperiod Influence Flowering and Morphology of Four Petunia spp." HortScience 45, no. 3 (March 2010): 365–68. http://dx.doi.org/10.21273/hortsci.45.3.365.

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Flowering and morphology of four Petunia Juss. spp. [P. axillaris (Lam.) Britton et al., P. exserta Stehmann, P. integrifolia (Hook.) Schinz & Thell., and P. ×hybrida Vilm.] were evaluated in response to photoperiod and temperature. Photoperiod responses were evaluated under 9-h short days (SD), 9-h photoperiod plus 4-h night-interruption lighting (NI), or a 16-h photoperiod supplemented with high-pressure sodium lamps (16-h HPS). All species flowered earlier under NI than SD and were classified as facultative (quantitative) long-day plants. Increasing the daily light integral within long-day treatments increased flower bud number for P. axillaris only. In a second experiment, crop timing and quality were evaluated in the temperature range of 14 to 26 °C under 16-h HPS. The rate of progress toward flowering for each species increased as temperature increased from 14 to 26 °C, suggesting the optimal temperature for development is at least 26 °C. The calculated base temperature for progress to flowering varied from 0.1 °C for P. exserta to 5.3 °C for P. integrifolia. Flowering of P. axillaris and P. integrifolia was delayed developmentally (i.e., increased node number below the first flower) at 14 °C and 17 °C or less, respectively, compared with higher temperatures. Petunia axillaris and P. integrifolia flower bud numbers decreased as temperature increased, whereas P. ×hybrida flower bud number was similar at all temperatures. The differences in crop timing and quality traits observed for these species suggest that they may be useful sources of variability for petunia breeding programs.

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Motoyasu, Akira, Kiyoshi Moriyama, Hiromu Okano, and Tomoko Yorozu. "High-flow nasal cannula therapy reduced the respiratory rate and respiratory distress in a standard model simulator and in patients with hypoxemic respiratory failure." Chronic Respiratory Disease 16 (January 1, 2019): 147997311988089. http://dx.doi.org/10.1177/1479973119880892.

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High-flow nasal cannula (HFNC) therapy has been increasingly applied to treat patients with severe hypoxemic respiratory failure. We investigated whether vital signs reflect the reduction of work of breathing in a simulator study and a clinical study. In the simulator study, a standard model high-fidelity human patient simulator (HPS) directly received 35 L/minute of 100% O2 via the HFNC. In the clinical study, the medical records of patients with hypoxemic respiratory failure who received HFNC therapy between January 2013 and May 2015 were retrospectively reviewed. Statistical analysis was performed using a one-way repeated analysis of variance followed by Bonferroni post-hoc testing. In the HPS, HFNC therapy significantly reduced the partial pressure of alveolar CO2, respiratory rate, and tidal volume ( p < 0.001), and all values returned to baseline following HFNC therapy termination ( p < 0.001). In the clinical study including 48 patients, the respiratory rate was significantly reduced from 27 ± 9 (baseline) to 24 ± 8 (3 hours), 24 ± 8 (5 hours), and 24 ± 8.0 (6 hours) ( p < 0.05). The heart rate also decreased significantly ( p < 0.05). Our results suggested that HFNC therapy reduced work of breathing and assessing vital signs can be important.

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Perez Botero, Juliana, Laynalee K. Cardel, Aneel A. Ashrani, John A. Heit, Rong He, C. Christopher Hook, Robert D. McBane, et al. "Platelet Transmission Electron Microscopy and Flow Cytometry in the Diagnosis of Congenital/Hereditary Qualitative or Quantitative Platelet Disorders." Blood 126, no. 23 (December 3, 2015): 3476. http://dx.doi.org/10.1182/blood.v126.23.3476.3476.

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Abstract Background Congenital/hereditary qualitative platelet disorders (CQPD) can be classified by platelet count (eg, normal or decreased) and platelet size as well as by functional defect. Based on mean platelet volume (MPV), congenital thrombocytopenias (CT) are classified as macro-thrombocytopenias (eg, Bernard-Soulier syndrome [BSS], MYH-9 [myosin heavy chain 9, non-muscle]-associated thrombocytopenias, gray platelet syndrome [GPS], etc.); microthrombocytopenias (eg, Wiskott-Aldrich syndrome and variants); and those with normal platelet size. CQPDs with normal platelet count include Glanzmann thrombasthenia (GT), dense granule storage pool disorders (DG-SPD) including Hermansky-Pudlak syndrome (HPS), platelet secretion disorders and many others. Diagnosis has relied on platelet counting and sizing, blood smear light microscopy, platelet aggregation (agg) and platelet function analyzer (PFA-100) studies. Platelet transmission electron microscopy (PTEM) and flow cytometry can provide supplementary information and molecular analysis is also evolving. The objective of this study was to determine the roles of platelet transmission electron microscopy (PTEM) and flow cytometry in the diagnosis of CQPD and CT. Methods In this retrospective cohort study, after IRB approval, the electronic medical record system was queried for patients (pt) with a confirmed CQPD or CT seen at Mayo Clinic between 2000 and 2015. A detailed chart review was undertaken. Results 54 pt (64% female) met our study criteria; median age was 32 years (range 1 day to 81 years). 18/54 (33%) pt had macrothrombocytopenia: BSS 4 (7%); MYH-9 10 (19%); gray platelet syndrome 4 (7%). 36/54 (66%) had normal MPV: Glanzmann thrombasthenia 6 (11%); storage pool disorders including DG-SPD 10 (19%) and HPS 2 (3%), mild alpha granule deficiency 3 (6%) and York platelet syndrome 4 (7%); platelet secretion disorders 4 (7%); ANKRD26 mutation 3 (6%); congenital amegakaryocytic thrombocytopenia 1 (2%); GATA-1 mutation 1 (2%); RUNX-1 mutation 1 (2%); and Jacobsen syndrome 1 (2%). 44 pt (81%) had a positive bleeding history: epistaxis 52%, cutaneous bleeding 57%, gastrointestinal bleeding 21% and menorrhagia 54%; 10 pt (19%) had a negative bleeding history. Results of standard and esoteric platelet testing are summarized in Table 1. Diagnosis in the 10 pt with glycoprotein deficiency (BSS or GT) was established by agg; flow cytometry was confirmatory but not necessary. Of the 23 pt with SPD, 5 had a negative bleeding history; 4 pt had normal agg and PFA-100 and were diagnosed exclusively by PTEM. In this group, the abnormalities on platelet aggregation and PFA were variable and PTEM allowed for a better definition of the specific abnormalities. For MYH-9 patients, PTEM confirmed leukocyte inclusions that had already been identified on light microscopy. PTEM was the only diagnostic modality able to identify the abnormality in York platelet syndrome. In 5/54 (9%) genetic testing was necessary for diagnosis (GATA-1, ANKRD26 and RUNX-1) Conclusion In this cohort, standard platelet assays established the diagnosis in the large majority of CQPD and CT. PTEM was essential for confirmation in DG-SPD, mild alpha granule deficiency and York platelet syndrome and useful in combination with molecular testing to establish a diagnosis in selected cases. Guidance on selection of patients for such specialized testing requires further study. Table 1. Results of standard and esoteric platelet testing for 54 patients with congenital qualitative platelet disorders and/or thrombocytopenia Disorder n (%) Platelet aggregation PFA PTEM Flow cytometry Confirmation by genetics Done Abnormal Done Abnormal Done Abnormal Done Abnormal Glanzmann thrombasthenia 6 (11) 6 6 5 5 1 0 3 3 0 Bernard-Soulier syndrome & variants 4 (7) 4 4 4 4 3 0 4 4 0 MYH-9 related disorders 10 (19) 7 2 8 3 5 5 4 2 5 Dense granule deficiency and HPS 12 (22) 12 8 12 8 12 12 4 0 0 Alpha granule deficiency* 7 (13) 7 4 7 6 7 7 4 4 1 York platelet syndrome 4 (7) 1 0 1 1 4 4 1 1 0 TXA2 or PG synthesis/receptor defect 4 (7) 4 4 4 3 3 0 3 0 0 CATM 1 (2) 0 - 0 - 0 - 0 - 1 ANKRD26 3 (6) 3 3 3 2 3 3 3 3 3 GATA-1 1 (2) 0 - 1 1 1 1 1 1 1 RUNX-1 1 (2) 1 0 1 1 0 - 0 - 1 Jacobsen syndrome 1 (2) 1 0 1 1 1 1 1 0 1 MYH-9: myosin heavy chain 9, non-muscle (MHY-9) associated thrombocytopenia, HPS: Hermansky-Pudlak Syndrome, TXA2: thromboxane A2, PG: prostaglandin CATM: congenital amegakaryocytic thrombocytopenia. * Includes gray platelet syndrome Disclosures Pardanani: Stemline: Research Funding.

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Meng, Qingwu, and Erik S. Runkle. "Controlling Flowering of Photoperiodic Ornamental Crops with Light-emitting Diode Lamps: A Coordinated Grower Trial." HortTechnology 24, no. 6 (December 2014): 702–11. http://dx.doi.org/10.21273/horttech.24.6.702.

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Photoperiodic lighting from lamps with a moderate ratio of red [R (600–700 nm)] to far-red [FR (700–800 nm)] light effectively promotes flowering of long-day plants (LDPs). Because of spectral controllability, long life span, and energy efficiency, light-emitting diodes (LEDs) have emerged as an alternative to conventional light sources, such as incandescent (INC) and high-pressure sodium (HPS) lamps. We conducted a coordinated trial with five commercial greenhouse growers to investigate the efficacy of R + white (W) + FR LEDs, with an R:FR of 0.82, to regulate flowering of daylength-sensitive ornamental crops. The trial was also performed in two replicate greenhouses at Michigan State University (MSU). Ageratum (Ageratum houstonianum), calibrachoa (Calibrachoa ×hybrida), dahlia (Dahlia ×hybrida), dianthus (Dianthus chinensis), petunia (Petunia ×hybrida), snapdragon (Antirrhinum majus), and verbena (Verbena ×hybrida) were grown under natural short days (SDs) with 4-hour night-interruption (NI) lighting provided by the R + W + FR LEDs or conventional lamps typically used by each grower. Two companies used HPS lamps, whereas the other sites used INC lamps. In addition, a natural SD treatment, a truncated 9-hour SD treatment, or a compact fluorescent lamp (CFL) NI treatment was provided at three different sites. With few exceptions, time to flower and flowering percentage of the bedding plant crops tested were similar under the R + W + FR LEDs to that under the conventional lamps at all sites. At MSU, ageratum, dianthus, petunia, snapdragon, and verbena flowered earlier under NI lighting treatments than under 9-hour SDs. In addition, plant height and visible flower bud or inflorescence number at flowering were similar under the R + W + FR LEDs and INC lamps for most crops. Therefore, we conclude that the R + W + FR LEDs are as effective as lamps traditionally used in greenhouses at controlling flowering of photoperiodic plants.

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Haddad, Philip A., and Nowell Ganey. "Abstract 4097: Clinicopathologic descriptors of subcutaneous panniculitis-like T-cell lymphoma (SPTCL): Analysis of a pooled database of a rare entity." Cancer Research 82, no. 12_Supplement (June 15, 2022): 4097. http://dx.doi.org/10.1158/1538-7445.am2022-4097.

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Abstract Introduction: SPTCL is a rare primary cutaneous T-cell lymphoma. SPTCL was initially described as an aggressive cutaneous T-cell lymphoma frequently associated with hemophagocytic syndrome (HPS) and requiring aggressive multiagent chemotherapy. In 2005, this entity was restricted to SPTCL with αβ phenotype, a less aggressive entity compared to its γδ counterpart, currently known as primary cutaneous γδ T-cell lymphoma. We conducted this analysis to explore the clinicopathologic characteristics of this little-known primary cutaneous T-cell entity. Methods: In order to study the demographic characteristics, molecular and immunohistochemical signatures, therapeutic interventions, survival, and prognostic factors, we compiled a pooled database of 214 cases. Descriptive statistics were calculated. Cox proportional-hazards model and Log-rank tests were used to assess the influence of demographic and clinicopathologic factors on overall survival (OS). Results: A total of 214 patients with confirmed SPTCL diagnosis were identified. The median age was 34 years with a peak incidence between ages 13 and 26. There was a female predominance with F:M ratio of 1.7. Upon presentation, 12% had lymphadenopathy, 12% had hepatosplenomegaly, and 27% had bone marrow involvement. No extra-nodal or extra-cutaneous involvement were reported. Cases expressed CD2 (8%), CD3 (85%), CD4(10%), CD5(10%), CD7 (9%), CD8 (77%), CD56 (6%), Granzyme-B (33%), and TIA-1 (34%). None of the cases expressed CD30. The most common clinical presentations were nodular skin changes (87%) followed by constitutional symptoms (57%). Fifteen and ten percent of SPTCL patients had history of immune-deregulatory disorders and immunosuppressive therapies, respectively. HPS occurred in 24% of the cases. Karyorrhexis, fat necrosis, and dermal involvement were noted in 15%, 9%, and 17%. The median duration of symptoms prior to diagnosis was 4 months. Median OS of the whole group was not reached while the mean OS was 73 months. OS was not impacted by sex, constitutional symptoms, immunocompromising factors, presence of lymphadenopathy, hepatosplenomegaly, or bone marrow involvement. OS was not impacted by histological or immunohistochemical features either. While older age and the occurrence of HPS negatively impacted OS, attaining complete remission positively impacted OS. Conclusions: This study presents a comprehensive clinicopathologic data from a pooled cohort of patients with SPTCL. It describes the clinicopathologic features of SPTCL and identifies major determinants of OS in this rare disease. Citation Format: Philip A. Haddad, Nowell Ganey. Clinicopathologic descriptors of subcutaneous panniculitis-like T-cell lymphoma (SPTCL): Analysis of a pooled database of a rare entity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 4097.

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Zhao, Dan, Jianpeng Guo, Hui Huang, Haibo Lin, Yichun Hong, Xueshang Feng, Jun Cui, et al. "Interplanetary Coronal Mass Ejections from MAVEN Orbital Observations at Mars." Astrophysical Journal 923, no. 1 (December 1, 2021): 4. http://dx.doi.org/10.3847/1538-4357/ac294b.

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Abstract The measurements from the Mars Atmosphere and Volatile EvolutioN spacecraft, in orbit around Mars, are utilized to investigate interplanetary coronal mass ejections (ICMEs) near 1.52 au. We identify 24 ICMEs from 2014 December 6 to 2019 February 21. The ICME list is used to examine the statistical properties of ICMEs. On average, the magnetic field strength of 5.99 nT in ICMEs is higher than that of 5.38 nT for stream interaction regions (SIRs). The density of 5.27 cm−3 for ICMEs is quite comparable to that of 5.17 cm−3 for SIRs, the velocity of 394.7 km s−1 for ICMEs is slightly lower than that of 432.8 km s−1 for SIRs, and the corresponding dynamic pressure of 1.34 nPa for ICMEs is smaller than that of 1.50 nPa for SIRs. Using existing databases of ICMEs at 1 au for the same time period, we compare ICME average properties at 1.52 au with those at 1 au. The averages of the characteristic quantities decrease by a factor of 1.1–1.7 from 1 to 1.52 au. In addition, we analyze an unusual space weather event associated with the ICME on 2015 March 9–10, and propose that the extremely strong dynamic pressure with a maximum of ∼18 nPa on March 8 is caused by the combined effects of the enhanced density inside a heliospheric plasma sheet (HPS), the compression of the HPS by the forward shock, and the high velocity of the sheath ahead of the ICME.

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Tocci, A., I. Parolini, M. Gabbianelli, U. Testa, L. Luchetti, P. Samoggia, B. Masella, G. Russo, M. Valtieri, and C. Peschle. "Dual action of retinoic acid on human embryonic/fetal hematopoiesis: blockade of primitive progenitor proliferation and shift from multipotent/erythroid/monocytic to granulocytic differentiation program." Blood 88, no. 8 (October 15, 1996): 2878–88. http://dx.doi.org/10.1182/blood.v88.8.2878.bloodjournal8882878.

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In preliminary studies, we have analyzed the hematopoietic growth factor (HGF) requirement of hematopoietic progenitor cells (HPCs) purified from embryonic-fetal liver (FL) and grown in fetal calf serum-supplemented (FCS+) clonogenic culture. The key role of erythropoietin (Epo) for colony formation by early erythroid progenitors (burst-forming units-erythroid [BFU-E]) has been confirmed. Furthermore, in the absence of exogenous HGFs, FL monocytic progenitors (colony-forming unit monocyte [CFU-M]) generate large colonies exclusively composed of monocytes-macrophages; these colonies are absent in FCS-clonogenic culture. On this basis, we have investigated the role of all-trans retinoic acid (ATRA) and its isomer 9-cis RA in FL hematopoiesis. Both compounds modulate the growth of purified FL HPCs, which show a dose-dependent shift from mixed/erythroid/ monocytic to granulocytic colony formation. Studies on unicellular and paired daughter cell culture unequivocally indicate that the shift is mediated by modulation of the HPC differentiation program to the granulopoietic pathway (rather than RA-induced down-modulation of multipotent/ erythroid/monocytic HPC growth coupled with recruitment of granulocytic HPCs). ATRA and 9-cis RA also exert their effect on the proliferation of primitive HPCs (high-proliferative potential colony-forming cells [HPP-CFCs]) and putative hematopoietic stem cells (HSCs; assayed in Dexter-type long-term culture). High concentrations of either compound (1) drastically reduced the number of primary HPP-CFC colonies and totally abolished their recloning capacity and (2) inhibited HSC proliferation. It is crucial that these results mirror recent observations indicating that murine adult HPCs transduced with dominant negative ATRA receptor (RAR) gene are immortalized and show a selective blockade of granulocytic differentiation. Altogether, these results suggest that ATRA/9-cis RA may play a key role in FL hematopoiesis via a dual effect hypothetically mediated by interaction with the RAR/RXR heterodimer, ie, inhibition of HSC/ primitive HPC proliferation and induction of CFU-GEMM/BFU-E/CFU-M shift from the multipotent/erythroid/monocytic to the granulocytic-neutrophilic differentiation program.

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Espinoza, Evelyn Patricia Sanchez, Lauro Viera Perdigão Neto, Sania Alves dos Santos, Camila Risek, Maria Renata Gomes Franco, Roberta C. R. Martins, Gaspar C. O. Pereira, et al. "1210. Investigating a Staphylococcus aureus Outbreak in a Clinical Intensive Care Unit: What Is the Role of the Mobile Phones?" Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S435. http://dx.doi.org/10.1093/ofid/ofz360.1073.

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Abstract Background Staphylococcus aureus (Sa) outbreaks are serious infections that if not controlled in time can be life-threating. The aim of this study was to describe the investigation and control of a Sa outbreak in an intensive care unit including analysis of MP. Methods During a microbiological research of MP conducted in December 2018 in a clinical intensive care unit (ICU) of a tertiary university hospital two patients had an MRSA infection. Since this unit had not reported MRSA infections during the last year it was recognized as an outbreak. The CDC criteria was applied to define MRSA colonization and infection. Hand hygiene (HH) adhesion in this unit was 47%,it has 9 beds and 30 Healthcare professionals (HP). Nasal Swab (NS) of all the HPs and of the patients in the same unit as well. HP’s MP were also analyzed. The samples were subjected to MALDI-TOF (Biomerieux), phenotypical tests, PCR for detection of gene coA and mecA, pulsed-field gel electrophoresis (PFGE), and whole-genome sequence to access resistance, virulence profile and sequence type. Feedback of microbiology results, reinforcement of hand hygiene and MP cleaning was discussed with the unit staff. Results A total of 34 samples were collected, 25 were Sa, 13 NS of all HPs and patients, 7 from the MPs and 3 from HPs hands. During the time of the outbreak 5 patients were in the unit. Patients with infection by MRSA (n = 2), had Methicillin-susceptible Sa in their NSs. Another patient that from the same unit had a MRSA in the NS that when submitted to PFGE was seen to be closely related with the MRSA that originated the outbreak. The patients isolates were assigned to different STs and they had more virulent and resistance genes in comparison with two samples of MPs. The Sa recovered from the MPs belonged to the same ST, same resistance gene and same virulent genes. Figure 1, Table1. Since the feedback to the unit no cases of MRSA have been reported in the last 4 months. Conclusion The outbreak was controlled using simply measures (feedback, reinforcement of HH and MP cleaning). The ST398 from the MP has already been described in outbreaks in literature. It seems that MP can be a reservoir for Sa There was more than one Sa lineage in the ICU. Our findings highlighted the need of rethinking the MP cleaning policy in our hospital. Disclosures All authors: No reported disclosures.

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Owen, W. Garrett, and Roberto G. Lopez. "Geranium and Purple Fountain Grass Leaf Pigmentation Is Influenced by End-of-Production Supplemental Lighting with Red and Blue Light-emitting Diodes." HortScience 52, no. 2 (February 2017): 236–44. http://dx.doi.org/10.21273/hortsci11098-16.

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Under low-light greenhouse conditions, anthocyanin pigmentation in vegetative tissues of red- or purple-leafed floricultural crops is not fully expressed and, consequently, plants are not as visually appealing to consumers. Our objective was to quantify the effect of end-of-production (EOP; before shipping) supplemental lighting (SL) of different light sources, qualities, and intensities on foliage color of geranium (Pelargonium ×hortorum L.H. Bailey ‘Black Velvet’) and purple fountain grass [Pennisetum ×advena Wipff and Veldkamp (formerly known as Pennisetum setaceum Forsk. Chiov. ‘Rubrum’)]. Plants were finished under early (Expt. 1) and late (Expt. 2) seasonal greenhouse ambient solar light and provided with 16 hours of day-extension lighting from low-intensity light-emitting diode (LED) lamps [7:11:33:49 blue:green:red:far-red light ratio (%); control] delivering 4.5 μmol·m−2·s−1, or 16 hours of EOP SL from high-pressure sodium (HPS) lamps delivering 70 μmol·m−2·s−1, or LED arrays (100:0, 87:13, 50:50, or 0:100 red:blue) delivering 100 μmol·m−2·s−1, or 0:100 red:blue LEDs delivering 25 or 50 μmol·m−2·s−1. Geranium and fountain grass chlorophyll content and leaf color were estimated using a SPAD-502 chlorophyll meter and Minolta tristimulus colorimeter, respectively. Relative chlorophyll content (RCC) and foliage L* (lightness), C* (chroma; a measure of saturation), and h° (hue angle; a measure of tone) values were significantly influenced by EOP SL and days of exposure. Generally, RCC of geranium and fountain grass increased from 3 to 14 days of exposure to EOP SL from HPS lamps and LEDs delivering 100 μmol·m−2·s−1. Under low daily light integrals (DLIs) [8.6 mol·m−2·d−1 (geranium) and 9.4 mol·m−2·d−1 (purple fountain grass)] EOP SL providing 100 μmol·m−2·s−1 of 100:0, 87:13, 50:50, or 0:100 red:blue light for ≥14 days resulted in lower L* (darker foliage), C* (saturated), and h° (orange to violet-red hues). Our data indicate that a minimum of 14 days of EOP SL providing 100 μmol·m−2·s−1 of 50:50 or 0:100 red:blue light enhanced foliage color of geranium and fountain grass leaves when plants were grown under a low greenhouse DLI ≤ 9 mol·m−2·d−1.

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Strickler, John H., Kimberly C. Banks, Rebecca J. Nagy, Richard B. Lanman, AmirAli Talasaz, Ryan Bruce Corcoran, and Scott Kopetz. "Blood-based genomic profiling of circulating cell-free tumor DNA (ctDNA) in 1397 patients (pts) with colorectal cancer (CRC)." Journal of Clinical Oncology 35, no. 4_suppl (February 1, 2017): 584. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.584.

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584 Background: ctDNA is shed into the bloodstream by tumor cells throughout the body, offering a non-invasive means of genomic testing, and a way to detect heterogeneous, subclonal genomic alterations present in distinct tumor lesions within an individual pt. However, a broad comparison of mutation prevalence in CRC ctDNA versus CRC tumor tissue has not yet been performed. Methods: ctDNA from 1397 CRC pts was analyzed using a CLIA-certified digital sequencing assay (Guardant360, Guardant Health) capable of detecting single nucleotide variants (SNV) in up to 70 genes, as well as selected insertions/deletions, amplifications, and fusions. Subclonal mutations were defined as mutations with mutant allele fractions (MAF) ≤ 50% of the greatest somatic MAF in the sample. Frequencies of mutations detected were compared to two large tissue-based sequencing databases (TCGA and NHS/HPS). Results: 1500/1772 (85%) tests had at least one genomic alteration (1397 unique pts). The most common SNV mutations included TP53 (62%), APC (47%), KRAS (39%), PIK3CA (17%), EGFR (11%), SMAD4 (11%), and BRAF (11%); these frequencies were comparable to rates in TCGA and NHS/HPS. In contrast, EGFR extracellular domain (ECD) mutations (42 pts) and JAK2 V617F mutations (16 pts) detected in ctDNA were not seen in tissue sequencing, reflecting acquired resistance to EGFR antibodies and clonal hematopoiesis of indeterminate clinical potential, respectively. 88% of pts with ECD mutations had at least one additional non-ECD resistance alteration detected in ctDNA (range 1-9, median 2.6), including KRAS, NRAS, BRAF, MAP2K1, MET and ERBB2. EGFR mutations were most likely to be detected as subclonal (86%), while mutations most likely to be clonal included KRAS (71%), TP53 (65%), BRAF (65%), and APC(63%). In 84 pts with serial monitoring, 87% had either gain (61%) or loss (63%) of clones over time. Conclusions: Blood-based genomic profiling can effectively detect common genomic alterations in CRC at comparable frequencies as observed in tissue and provide novel insights into tumor clonality and clonal dynamics. Clinical trials to target EGFR ECD mutations may be limited by the multiplicity of resistance mechanisms in each pt.

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Hamaker, Cheryl, William H. Carlson, Royal D. Heins, and Arthur C. Cameron. "Influence of Daylength Delivery on Flowering in Several Herbaceous Perennial Species." HortScience 30, no. 4 (July 1995): 861F—861. http://dx.doi.org/10.21273/hortsci.30.4.861f.

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To determine the most effective lighting strategies for flower induction of long-day (LD) plants, 10 species of herbaceous perennials were chilled at 5C for 0 or 12 weeks and then forced at 20C under the following photoperiods: short day, 4-h night interruption (4-h NI), 7-h night interruption (7-h NI), 7-h day extension, 7-h predawn (7-h PD), and 24-h continuous light (24-h). All treatments consisted of a 9-h photoperiod of sunlight supplemented with 90 μmol·m–2 from HPS lamps. LD treatments were delivered by incandescent lights and induced flowering in obligate LD plants. Rate of flowering, height, and bud number at first flower varied among species and LD treatments. Although flowering was accelerated under 24-h and 7-h NI for most species, it was delayed under 24 h for Coreopsis verticillata `Moonbeam' and Campanula carpatica. For unchilled plants of most species, flowering was delayed under 7-h PD compared to other LD treatments. Chilling decreased time to flower and reduced differences between LD treatments. Coreopsis `Moonbeam' and C. Ianceolata `Early Sunrise' were shorter when grown under 4-h NI.

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Zhang, X., J. W. White, and D. J. Beattie. "Regulation of Flowering in Aquilegia." Journal of the American Society for Horticultural Science 116, no. 5 (September 1991): 792–97. http://dx.doi.org/10.21273/jashs.116.5.792.

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Aquilegia × hybrida Sims `Purple' and `Dove' initiated flower buds 5 months after seeding without being exposed to low temperatures. Four experiments were conducted to test the effects of gibberellic acid (GA3), long photoperiod, long photoperiod with a high level of irradiance, and cold treatments on forcing of the two cultivars. Time from treatment to anthesis was reduced by 9 days for defoliated `Purple' plants treated with 250 mg GA3/liter, and by >14 days for defoliated `Dove' plants treated with 125 mg GA3/liter. Defoliated `Purple' or `Dove' plants treated with 18 hours of supplemental high pressure sodium (HPS) light at 250μl mol·m-1·s-2 (18 SH) reached anthesis 14 or 10 days earlier, respectively, after treatment than plants grown under natural daylight (Nat). The 18 SH treatment increased the number of flowers from eight and nine per plant on Nat plants for defoliated `Dove' and `Purple', respectively, to 16 flowers on 18 SH plants. Cold treatments at 4 ± lC did not shorten the interval between treatment and anthesis, but decreased the number of flowers per plant in both cultivars. Chemical name used: gibberellic acid (GA3).

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Verschure, Pernette J., Ineke van der Kraan, Wim de Leeuw, Johan van der Vlag, Anne E. Carpenter, Andrew S. Belmont, and Roel van Driel. "In Vivo HP1 Targeting Causes Large-Scale Chromatin Condensation and Enhanced Histone Lysine Methylation." Molecular and Cellular Biology 25, no. 11 (June 1, 2005): 4552–64. http://dx.doi.org/10.1128/mcb.25.11.4552-4564.2005.

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ABSTRACT Changes in chromatin structure are a key aspect in the epigenetic regulation of gene expression. We have used a lac operator array system to visualize by light microscopy the effect of heterochromatin protein 1 (HP1) α (HP1α) and HP1β on large-scale chromatin structure in living mammalian cells. The structure of HP1, containing a chromodomain, a chromoshadow domain, and a hinge domain, allows it to bind to a variety of proteins. In vivo targeting of an enhanced green fluorescent protein-tagged HP1-lac repressor fusion to a lac operator-containing, gene-amplified chromosome region causes local condensation of the higher-order chromatin structure, recruitment of the histone methyltransferase SETDB1, and enhanced trimethylation of histone H3 lysine 9. Polycomb group proteins of both the HPC/HPH and the EED/EZH2 complexes, which are involved in the heritable repression of gene activity, are not recruited to the amplified chromosome region by HP1α and HP1β in vivo targeting. HP1α targeting causes the recruitment of endogenous HP1β to the chromatin region and vice versa, indicating a direct interaction between the two HP1 homologous proteins. Our findings indicate that HP1α and HP1β targeting is sufficient to induce heterochromatin formation.

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Friedman, Harvey M., and Andrej Ščedrov. "On the quantificational logic of intuitionistic set theory." Mathematical Proceedings of the Cambridge Philosophical Society 99, no. 1 (January 1986): 5–10. http://dx.doi.org/10.1017/s0305004100063854.

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Formal propositional logic describing the laws of constructive (intuitionistic) reasoning was first proposed in 1930 by Heyting. It is obtained from classical pro-positional calculus by deleting the Law of Excluded Middle, and it is usually referred to as Heyting's (intuitionistic) propositional calculus ([9], §§23, 19) (we write HPP in short). Formal logic involving predicates and quantifiers based on HPP is called Heyting's (intuitionistic) predicate calculus ([9], §§31, 19) (we write HPR in short).

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Baig, Mirza Asif, Swamy KB, Fawzia Sharaf, Ibrahim Mehmood, Ameen K. Baksh, Yasser Moshrif, Ahmed Bahashwan, et al. "To Study the Role of Bone Marrow Aspiration in Etiological categorization of Pediatric Pancytopenia." Annals of Pathology and Laboratory Medicine 9, no. 7 (August 11, 2022): A139–147. http://dx.doi.org/10.21276/apalm.3172.

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Background: Pancytopenia is a Clinico-hematological entity, characterized by a triad of Anemia, leucopenia, and thrombocytopenia. The criterion for defining Pancytopenia is HGB < 9 g/dl: ANC < 1.5 x 109/L and platelet count <100 x 109/L. The main objective of this study is to categorize pediatric pancytopenia’s on etiological basis and to study the age wise incidence. Methodology and Results: This is a 5-year study (2016-2021) conducted in tertiary care pediatric referral hospital. All data were expressed as Mean +/ - SD and p value <0.05 is taken as statistically significant. A total of 500 bone marrow smears of pancytopenic patients were studied, of which 60% were boys & 40% girls, 64% constituted Malignant diseases and 36% were benign. Incidence wise, ALL is the most common and pancytopenia being 2nd and together comprises 64% of total cases. Some rare cases like AML –M6 in 2 months old, Chediak higashi syndrome and Familial Hemophagocytic syndrome were noted. Flow cytometry and Molecular genetics were done were ever required. Conclusion: Bone Marrow Aspiration is a reliable and sensitive test which can be used in investigation of Pediatric pancytopenia’s and if used meticulously with other routine hematological tests can give a high diagnostic accuracy. ALL is most common in our study (other studies showed Aplastic anemia), AML-M6 in 2 months, LD bodies in bone marrow, HPS were amongst the rare cases

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Journal articles on the topic 'HPS-9'

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