Dissertations / Theses on the topic 'Host-bacterial interaction'
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de, Klerk Nele. "Host-bacteria interactions : Host cell responses and bacterial pathogenesis." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-126425.
Full textAt the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 4: Manuscript.
Shah, Samir Ashok. "The Effect of Smoking on Host-Bacterial Interaction." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338316888.
Full textAkpa, Abubakar Dominic. "Host-parasite interaction in bacterial blight of pea caused by Pseudomonas syringae pv. pisi." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47328.
Full textAljannat, Mahab. "Bacterial moonlighting proteins of N. meningitidis : interaction with the host and role in pathogenesis." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/41073/.
Full textMaldonado-Arocho, Francisco J. "Characterization of host-pathogen interaction of two bacterial toxins anthrax edema toxin and Escherichia coli cytolethal distending toxin /." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1973060671&sid=4&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Full textLopez, Fernandez Juan Sebastian [Verfasser], and Michael [Akademischer Betreuer] Steinert. "Molecular ecological interaction of bacterial endophytes with their host Vitis vinifera (L) / Juan Sebastian Lopez Fernandez ; Betreuer: Michael Steinert." Braunschweig : Technische Universität Braunschweig, 2017. http://d-nb.info/1175817228/34.
Full textLopez, Fernandez Juan Sebastian Verfasser], and Michael [Akademischer Betreuer] [Steinert. "Molecular ecological interaction of bacterial endophytes with their host Vitis vinifera (L) / Juan Sebastian Lopez Fernandez ; Betreuer: Michael Steinert." Braunschweig : Technische Universität Braunschweig, 2017. http://nbn-resolving.de/urn:nbn:de:gbv:084-2017072708547.
Full textShekhar, Sudhanshu. "A study on the role of lung dendritic cells and their interaction with innate lymphocytes in host defense against a bacterial lung infection." Karger, 2015. http://hdl.handle.net/1993/30622.
Full textOctober 2015
Yan, Shuangchun. "Using the Bacterial Plant Pathogen Pseudomonas syringae pv. tomato as a Model to Study the Evolution and Mechanisms of Host Range and Virulence." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77293.
Full textPh. D.
Dorling, Jack. "Peptidoglycan recycling in the Gram-positive bacterium Staphylococcus aureus and its role in host-pathogen interaction." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:3fc4f926-296d-43a1-bb45-af9f37a87d8d.
Full textBatista, Diego Felipe Alves [UNESP]. "Avaliação da patogenicidade de estirpes mutantes de Salmonella Gallinarum biovar Gallinarum para genes relacionados ao metabolismo naturalmente defectivos em S. Gallinarum biovar Pullorum." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151213.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O tifo aviário, causado por Salmonella Gallinarum biotipo Gallinarum, é uma infecção caracterizada pela alta mortalidade nos lotes de aves suscetíveis acometidos, enquanto S. Gallinarum biotipo Pullorum, o agente da pulorose, infecta as aves de produção industrial com as quais desenvolve relação mais branda. Ainda é escasso o conhecimento sobre os mecanismos moleculares que sustentam essas diferentes interações patógeno-hospedeiro. Nesse estudo, objetivou-se investigar o efeito de deleção parcial das sequências codificantes dos genes idnT (transportador de L-idonato ou D-gluconato), idnO (5-cetogluconato redutase) e ccmH (heme liase necessária na montagem de citocromos do tipo C) sobre a patogenicidade de S. Gallinarum 287/91 (SG287/91), uma vez que seus ortólogos são pseudogenes conservados em S. Pullorum. Os clones mutantes SG∆idnTO, SG∆ccmH e SG∆ccmHidnTO foram obtidos por meio da técnica de mutação sítio-dirigida, denominada de recombinação Lambda-Red e testados em dois experimentos independentes com aves comerciais semipesadas de postura suscetíveis ao tifo aviário. No 1º experimento não se observou alteração da patogenicidade dos clones mutantes após inoculação oral, pois todos os animais infectados desenvolveram sinais clínicos típicos do tifo aviário e vieram a óbito ao longo de 12 dias pós-infecção (dpi). Apesar dos 100% de mortalidade, as infecções desenvolvidas pelos clones SG∆idnTO e SG∆ccmHidnTO levaram os animais a óbito dentro de 48 horas desde o aparecimento dos sinais clínicos, enquanto SG287/91 o fez em 6 dias, sugerindo aumento da virulência dos clones mutantes. No 2º experimento observou-se que as mutantes invadiram o hospedeiro a partir do intestino, embora as quantidades recuperadas de SG∆idnTO e SG∆ccmHidnTO nos fígados e de SG∆idnTO nos baços, no 5º dpi, foram superiores a de SG287/91, reforçando a hipótese de aumento da virulência dos clones contendo a alteração idnTO. Apesar disso, os níveis de transcrição das citocinas CXCLi2 e IL6 produzidos à infecção por SG∆idnTO e SG∆ccmHidnTO não diferiram nas tonsilas cecais nos 1º e 3º dpi e nos baços no 3º dpi em relação à infecção por SG287/91. Somente SG∆ccmH inclinou-se a estimular a transcrição de CXCLi2 e IL6 nas tonsilas cecais no 1° dpi em relação ao grupo controle, enquanto SG287/91 tendeu a suprimi-la. Porém, não houve suporte estatístico para essa observação. Os níveis de mRNA do IFNγ estavam aumentados para todas as estirpes de S. Gallinarum, mutantes ou não, porém sem diferença estatística entre eles. Os resultados do presente estudo indicam que a ruptura nos genes idnTO, e em menor grau do gene ccmH, poderiam levar a perda de “fitness” em S. Gallinarum, lhes justificando a permanência no genoma desse micro-organismo, ao contrário do que ocorre com S. Pullorum. O estudo da patogenicidade de estirpe de S. Pullorum tendo reconstituídos os genes idnTO e ccmH no seu genoma poderia esclarecer os motivos pelos quais esses foram negativamente selecionados por esse micro-organismo.
Fowl typhoid, caused by Salmonella Gallinarum biovar Gallinarum, is an infectious disease which elicits high mortality into a flock of susceptible birds whereas S. Gallinarum biovar Pullorum, the aetiological agent of pullorum disease, infects poultry of commercial importance with which such a bacterium sets off a more permissive host-pathogen interaction. Little is known about the molecular mechanisms driving these distinct interplays with the host. Herein, we aimed at investigating the effect of partial deletions in the idnT (L-idonate / D-gluconate transporter), idnO (5-ketogluconase reductase) and ccmH (heme liase involved in the c-type cytochrome maturation) coding sequences on S. Gallinarum 287/91 (SG287/91) pathogenicity since they are conserved pseudogenes in S. Pullorum genomes. SG∆idnTO, SG∆ccmH and SG∆ccmHidnTO mutant strains were constructed through a one-step inactivation technique, known as Lambda-Red-mediated recombination, and tested on two independent experiments by using a commercial brown egg-producing layer line susceptible to fowl typhoid. On the experiment 1, no changing was observed in the pathogenicity of the mutant strains upon oral inoculation as the infected animals developed typical fowl typhoid clinical signs and died along 12 days post-infection (dpi). In spite of causing 100% mortality, SG∆idnTO and SG∆ccmHidnTO killed all the animals within 48 hours since the clinical signs appearance while SG287/91 did so in 6 days, indicating an increased virulence by these mutant strains. On the experiment 2 every mutant strain were able to invade the host system from the intestine albeit SG∆idnTO and SG∆ccmHidnTO were recovered from livers and SG∆idnTO alone from spleens at higher numbers than was SG287/91, supporting the hypothesis of increased virulence for those clones harbouring the idnTO mutation. Despite the results above, CXCLi2 and IL6 transcription levels during infection by SG∆idnTO and SG∆ccmHidnTO were similar to that induced by SG287/91 in caecal tonsils at 1 and 3 dpi and in spleens at 3 dpi. In contrast, SG∆ccmH trended to stimulate CXCLi2 and IL6 transcription in caecal tonsils at 1 dpi when compared to the negative, control group whereas SG287/91 tended to suppress it, but no statistical significance was found for such an observation. IFNγ mRNA were augmented for all S. Gallinarum strains, mutant or not, but without statistical difference amongst them. These findings indicate that gene decay into idnTO, and at a lesser extent, into ccmH sequences might lead to the loss of fitness by S. Gallinarum, raising an explanation for their maintenance on this bacterium chromosome when the opposite happens to S. Pullorum. Studying the pathogenicity of a S. Pullorum strain possessing both the idnTO and ccmH genes in its genome could bring to light the reasons whereby such genes were negatively selected by this microorganism.
FAPESP: 2013/22920-4
FAPESP: 2013/26127-7
Cossé, Mathilde. "Identification et caractérisation d'un nouvel effecteur précoce de Chlamydia trachomatis." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066083/document.
Full textC. trachomatis is an obligate intracellular Gram-negative bacteria and a human pathogen. It is the most prevalent cause of sexually transmitted diseases of bacterial origin and a leading cause of preventable blindness in the developing world. During their biphasic developmental cycle the bacteria remains in a membrane-bounded cellular compartment called an inclusion. Using a type 3 secretion system (T3SS) they translocate effector proteins inside the cytosol of the cell to promote its survival and multiplication.The aim of the PhD was to study the function of CT622, a hypothetic protein from C. trachomatis. We showed that CT622 is an effector protein from the T3SS and that it is secreted early during the infection. We identified a bacterial protein that binds to CT622, and we showed that it acts as a chaperone, stabilizing CT622 and enhancing its secretion. We obtained bacteria lacking CT622 expression, thus demonstrating that CT622 is not essential for bacterial growth in vitro. However, preliminary studies indicate that in the absence of CT622 bacterial development is delayed and T3SS is defective.We identified several molecules interacting with CT622: geranylgeranyl diphosphate, Rab39 and Atg16L1 proteins. Future work will aim at understanding how these identified interactions, or other bacterial or cellular partners still to be discovered, contribute to the establishment of a niche favorable to bacterial development
Venkatesh, Balakrishnan. "Characterization of bacterial Lipopolysaccharides (Pseudomonas syringae pv. tomato and Pseudomonas syringae pv. apii) and pectins of tomato and celery plants (Lycopersicon esculentum and Apium graveolens) regarding their possible rolle in host, pathogen interaction." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966627423.
Full textRaffetseder, Johanna. "Interplay of human macrophages and Mycobacterium tuberculosis phenotypes." Doctoral thesis, Linköpings universitet, Avdelningen för mikrobiologi och molekylär medicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132321.
Full textBringel, Jose Magno Martins. "Caracterização bioquímica, patogênica e molecular de isolados de Ralstonia solanacearum biovar 2 de batata e berinjela." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/11/11135/tde-09012003-081030/.
Full textThe bacterial wilt disease caused by Ralstonia solonacearum affects mainly the solanaceous species, specially potato, eggplant, peppers, tomato and brazilian gilo (Solanum gilo). This work reports the molecular characterization of R. solanacearum biovar 2 isolates and the possible relationship of this molecular data with other characteristics related to morphology, biochemistry, pathogenicity, aggressiveness and geographical distribution. Fifty-one biovar 2 isolates were studied, 9 isolated from eggplant and 42 from potato, all of them collected from different regions of Brazil. According to the molecular analysis, the isolates were clustered in four different groups, with distinct band patterns to the primers BOX and ERIC, and five groups to the primers REP. There was no relationship between the groups clustered through molecular analyses and phenotypic characteristics, such as colony size, presence of mutants, melanin presence, capability of root system colonization and antibiotic/fungicide resistance. The identification of potato isolates as the biovar 2-A, and the eggplant isolates as biovar 2-T, based on biochemical tests using trealose were confirmed with the molecular analyses. There was no variation of aggressiveness in the isolates inoculated on potato an eggplant, except the avirulent isolate CNPH-65. Consequently, isolates of biovars 2-A and 2-T are able to infect both hosts with the same aggressiveness under high temperatures. The population of all isolates developed in significant levels at the root system of susceptible cultivars of both hosts, potato and eggplant. However, considering each cultivar tested, there was no difference between isolates. Interesting results were observed when the isolates clustered based on molecular data were associated with the geographical region of their collection. The group I clustered only the isolates collected in Paraná. The group II clustered the isolates collected in Bahia, Federal District and some in Paraná. The group III clustered all isolates from eggplant and only one of potato, all of them collected in the Federal District. The group IV, as the group II, clustered isolates from different regions, like Paraná, Goiás, Rio Grande do Sul and Federal District. These results suggest a relationship between the isolates clustered through molecular analysis in the groups II and III and their geographical region of collection. The isolates clustered in the same way, with similar genetic background in the groups II and IV, were however collected in different regions, showing the great genetic variation of this pathogen.
Su, Bin. "Interaction between gastric pathogen Helicobacter pylori and host cells /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3423-1/.
Full textBush, Victoria Louise. "The interaction of Neisseria meningitidis with host cells." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361473.
Full textAdams, Diane. "Host plant effects on an aphid-bacterial symbiosis." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337152.
Full textHaggar, Axana. "Interaction between Extracellular adherence protein (Eap) from Staphylococcus aureus and the human host." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-496-1/.
Full textHarden, Mark Michael Jr. "Interactions between an integrative and conjugative element and its bacterial host." Thesis, Massachusetts Institute of Technology, 2021. https://hdl.handle.net/1721.1/130662.
Full textCataloged from the official PDF of thesis.
Includes bibliographical references.
Conjugative elements are mobile genetic elements that can transfer from a donor bacterium to a recipient via an element-encoded type IV secretion system. Integrative and conjugative elements (ICEs) are an abundant class of conjugative element. ICEs are typically integrated into the bacterial host chromosome, but under certain conditions, or stochastically, they can excise from the chromosome and transfer to a recipient. ICEs likely interact with their bacterial host at every stage of their life cycle, but few of these interactions have been characterized. In this work I sought to 1) identify bacterial host factors necessary for efficient transfer of the integrative and conjugative element ICEBs1 to a recipient, and 2) determine whether the ICEBs1-encoded cell wall-modifying enzyme CwlT acts on the cell wall of the donor bacterium, the recipient bacterium, or both.
I used CRISPR interference to induce a knockdown of individual essential Bacillus subtilis genes, and then screened for gene knockdowns that caused an acute defect in transfer of ICEBs1. I found that wall teichoic acids were necessary in both ICEBs1 donors and recipients for efficient conjugative transfer. I found that depletion of wall teichoic acids caused cells involved in ICEBs1 conjugation to sustain lethal envelope damage caused by active conjugation machinery. Conjugative elements must bypass the cell wall of both the donor and recipient cells in a mating pair. Conjugative elements encode cell wall hydrolases that are required for efficient transfer, which are presumed to partly degrade the cell wall of the donor bacterium during conjugation. In order to investigate the role of the ICEBs1-encoded cell wall hydrolase CwlT in conjugation, I generated cell wall-less (L-form) strains of B. subtilis which could donate or receive ICEBs1.
In the absence of either the donor or recipient cell wall, CwlT was dispensable for efficient transfer. This finding indicates that CwlT acts on both the donor and recipient cell wall in a mating pair.
by Mark Michael Harden, Jr.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biology
Tsai, Yu-Huan. "Investigating human neurolisteriosis with relevant host and bacterial partners." Paris 7, 2014. http://www.theses.fr/2014PA077232.
Full textListeria monocytogenes (Lm) is a bacterial foodbome pathogen that crosses the intestinal barrier via the interaction of its surface protein InIA with its receptor E-cadherin (Ecad), and disseminate within the host to induce listeriosis. Lm can cross the placental barrier in pregnant women resulting in abortion and fetal infection, and cross the blood-CNS barrier to cause neurolisteriosis via a so far unknown mechanism. InIA-Ecad interaction is species-specific, does not occur in wild-type (wt) mice, but does in humanized mice expressing humanized mouse Ecad. InIA has also been "murinized" (InlAm) to interact with mouse Ecad in wt mice. We have shown that InlAm not only interacts with mouse Ecad, but also uses N-cadherin (Ncad) as a receptor, whereas InIA does not. This unanticipated and artifactual InlAm-Ncad interaction promotes bacterial translocation across villous M cells, accompanying with intestinal inflammation and intestinal barrier damage, ail of which are not seen in humans and humanized mouse models permissive to In1A-Ecad interaction. The widely used reference strains are not representative of clinical isolates, based on MLST, a sequence-based typing method. We have shown in a humanized mouse model of listeriosis developed in the laboratory, that the isolates originating from the most prevalent clones responsible for human neurolisteriosis are more virulent and induce far more efficiently neurolisteriosis than isolates from other clonai complexes and reference strains. By use of the humanized mouse model and relevant human CNS isolates, we are investigating the pathogenesis of orally acquired neurolisteriosis, and deciphering the underlying mechanisms of neurolisteriosis
Matthews, Chad Robert. "Host Bacterial Interactions During Early Plaque Formation in Current and Never Smokers." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1274112198.
Full textTurse, Joshua Edward. "Concerning Brucella LPS: genetic analysis and role in host- agent interaction." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4442.
Full textWhite, Corin Vashoun. "The interaction between Caenorhabditis elegans and the bacterial pathogen Stenotrophomonas maltophilia." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/20386.
Full textBiology
Michael A. Herman
Nematodes play an important role in various habitats where numerous factors serve to shape their communities. One such factor is the potentially pathogenic nematode-prey interaction. This project is focused on the elucidation of the genes that the bacterivorous nematode Caenorhabditis elegans employs to respond to the emerging nosocomial bacterial pathogen Stenotrophomonas maltophilia. A virulent S. maltophilia strain JCMS requires the action of several C. elegans conserved innate immune pathways that serve to protect the nematode from other pathogenic bacteria. However, insulin-like DAF-2/16 signaling pathway mutants that are typically pathogen resistant are susceptible to JCMS, and several DAF-2/16 regulated genes are not significantly differentially expressed between JCMS and avirulent E. coli OP50. We have determined the complete set of mRNA transcripts under different bacterial treatments to identify genes that might explain this JCMS specific DAF-2/16 pathway evasion. The identified set included 438 differentially expressed transcripts among pairwise comparisons of wild-type nematodes fed OP50, JCMS or avirulent S. maltophilia K279a. Candidate genes were nominated from this list of differentially expressed genes using a probabilistic functional connection model. Six of seven genes that were highly connected within a gene network generated from this model showed a significant effect on nematode survival by mutation. Of these genes, C48B4.1, mpk-2, cpr-4, clec-67 and lys-6 are needed for combating JCMS, while dod-22 was solely involved in K279a response. Only dod-22 had a documented role in innate immunity, which merits our approach in the identification of gene candidates. To a lesser extent, we have also focused on the identification of virulence factors and the mode of action employed by S. maltophilia. JCMS virulence requires rpfF, xps and involves living bacteria that accumulate in the intestinal lumen. Additionally, the bacterial secretion encoding genes cs, p773, p1176, pi1y1 and xdi are involved in JCMS evasion of daf-2. In summary, we have discovered a novel host-pathogen interaction between C. elegans and S. maltophilia JCMS, revealed genes that are involved in each partner of the interaction, and established a new animal model for the study of S. maltophilia mode of action.
Tujulin, Eva. "Host interactions of the intracellular bacterium Coxiella burnetii : internalisation, induction of bacterial proteins and host response upon infection /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5425-5.pdf.
Full textMoman, Raja. "Interactions of oral bacteria with host tissues and allochthonous microorganisms." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/interactions-of-oral-bacteria-with-host-tissues-and-allochthonous-microorganisms(4ddfd193-ba44-4062-8603-2082f2269273).html.
Full textSuri, Reetika. "The effect of welding fumes and smoking on host-pathogen interactions in bacterial pneumonia." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9100.
Full textVaitkevičius, Karolis. "Effects of Vibrio cholerae protease and pigment production on environmental survival and host interaction /." Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1474.
Full textHutchinson, J. L. "Intracellular targeting mechanisms of Salmonella virulence effector proteins, and bacterial interactions with host antigen presentation pathways." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604849.
Full textVries, Frederik Peter de. "Colonization and invasion of human epithelia by Neisseria meningitidis bacterial surface variation and exploitation of host defense molecules /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/58434.
Full textOlive, Andrew James. "Immunity to Chlamydia trachomatis and Host-Pathogen Interactions During Infection." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11263.
Full textBoardman, Cynthia. "Host-Pathogen Interactions between Eastern Oysters (Crassostrea virginica) and the Bacterial Agent of Juvenile Oyster Disease (Roseovarius crassostreae)." Fogler Library, University of Maine, 2005. http://www.library.umaine.edu/theses/pdf/BoardmanC2005.pdf.
Full textBjörkqvist, Maria. "Coagulase-negative staphylococci septicaemia in newborns : aspects on host-bacterial interactions with special regard to neutrophil and endothelial response /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/med861s.pdf.
Full textSokolova, Nadiia Verfasser], and Theresia [Akademischer Betreuer] [Stradal. "Identification and characterization of interactions between bacterial WxxxE-virulence proteins and host cell proteins / Nadiia Sokolova ; Betreuer: Theresia Stradal." Braunschweig : Technische Universität Braunschweig, 2017. http://d-nb.info/1175817961/34.
Full textThay, Bernard. "Vesicle-mediated and free soluble delivery of bacterial effector proteins by oral and systemic pathogens." Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82782.
Full textLanger, Melissa Natalie [Verfasser]. "Interactions of host defence peptides with innate immune cells : unravelling molecular mechanisms of immune modulation and bacterial killing / Melissa Natalie Langer." Hannover : Stiftung Tierärztliche Hochschule Hannover, 2018. http://d-nb.info/118040288X/34.
Full textJehl, Marc-André [Verfasser], Dmitrij [Akademischer Betreuer] [Gutachter] Frischmann, and Thomas [Gutachter] Rattei. "Computational methods for the prediction of bacterial pathogen-host protein protein interactions / Marc-André Jehl. Betreuer: Dmitrij Frischmann. Gutachter: Thomas Rattei ; Dmitrij Frischmann." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1100689001/34.
Full textBhullar, Kirandeep. "Mucus-bacteria interactions in the gut : investigating the role of the mucin Muc2 and its glycosylation in host defense during enteric bacterial infections." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57682.
Full textMedicine, Faculty of
Medicine, Department of
Experimental Medicine, Division of
Graduate
Ripert, Gabrielle. "Etude du mode d’action des souches Bacillus subtilis CU1 et Bacillus clausii O/C, probiotiques humains, et de leurs interactions avec l'hôte via des modèles in vitro et in vivo." Thesis, Paris, AgroParisTech, 2013. http://www.theses.fr/2013AGPT0019.
Full textProbiotic are ”live microorganisms, which when administered in adequate amounts confer a health benefit on the host”. They act by modulating the immune system, preventing the adhesion and / or growth of pathogenic bacteria, reinforcing the intestinal barrier and stabilizing the microbiota.However, the mechanisms of action of these bacteria are still poorly understood.This thesis proposes to elucidate the mode of action of two human probiotic strains of Bacillus : Bacillus clausii O / C and Bacillus subtilis CU1.The adhesion of probiotics to intestinal surfaces is an important factor for their persistence in the host, immunomodulation and competition with pathogens. B. clausii and B. subtilis have strong abilities to adhere as spores, through their surface-associated proteins which are preferentially involved in interactions with the host. Indeed, they play a key role in the up-regulation of gene expression encoding cytokines in Caco-2 cells and in the stimulation of cytokine production by immune cells, induced by probiotic strains, through binding with host receptors. Some S-layers proteins, ribosomal proteins and proteases have been identified on the surface of these strains, and a large quantity of flagellin on the surface of B. subtilis.In addition, secreted compounds of these probiotics also stimulate the production of chemotactic and anti-inflammatory cytokines. B. clausii secretes a protease able to neutralize several types of toxins, including those secreted by C. difficile and B. cereus. B. subtilis has not predisposition to compete with the adhesion of pathogens tested, but a clinical trial has demonstrated its ability to modulate the immune system and the composition of the intestinal microbiota
Schrallhammer, Martina, Filippo Ferrantini, Claudia Vannini, Stefano Galati, Michael Schweikert, Hans-Dieter Görtz, Franco Verni, and Giulio Petroni. "'Candidatus Megaira polyxenophila' gen. nov., sp. nov.: Considerations on Evolutionary History, Host Range and Shift of Early Divergent Rickettsiae." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127288.
Full textBaudry, Lyam. "Investigating chromosome dynamics through Hi-C assembly." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS026.
Full textThe advent of high-throughput DNA sequencing technologies has set off an expanding trend in genome assembling and scaffolding. Such genome quality is an essential preliminary to understand interactions between and among chromosomes. We built upon a computational and technological framework that let us tackle genome assembly problems of increasing complexity. Our methods are mainly based on chromosome conformation capture technologies such as Hi-C. In a Hi-C experiment, DNA molecules are cross-linked with the surrounding proteins and form a large, static protein-DNA complex. This captures the spatial conformation by trapping together molecules that are physically close to each other. Therefore, Hi-C is very suitable for 3D genome structure analysis, which lets us infer a wealth of information about the genome. It was indeed shown that the tridimensional structure of the genome can be unambiguously linked to its 1D structure thanks to the physical properties of DNA polymers. Moreover, such 3D proximity also gives access to cell compartment information, thus opening the way for an additional approach for metagenomic binning, known as meta3C. In this work, we expand upon these methods and apply them to use cases with more and more complexity. We first improve on tools for genome assembly and demonstrate their validity with the scaffolding of Ectocarpus sp., then unveil rearrangements in joint scaffoldings of Trichoderma reesei and Cataglyphis hispanica. Lastly, we use the same approach with metagenomic binning on live mouse microbiome samples to reconstruct hundreds of genomes
Olofsson, Jenny. "Amoebae as Hosts and Vectors for Spread of Campylobacter jejuni." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-255804.
Full textWeng, Dan. "Caspase-8 and RIP Kinases Regulate Bacteria-Induced Innate Immune Responses and Cell Death: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/727.
Full textWeng, Dan. "Caspase-8 and RIP Kinases Regulate Bacteria-Induced Innate Immune Responses and Cell Death: A Dissertation." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/727.
Full textGeniez, Sandrine. "Investigation of Wolbachia symbiosis in isopods and filarial nematodes by genomic and interactome studies." Thesis, Poitiers, 2013. http://www.theses.fr/2013POIT2277/document.
Full textBacteria of the genus Wolbachia are gram-negative alpha-proteobacteria present in many arthropods and filarial nematodes. These obligate intracellular bacteria are maternally inherited and induce a large number of phenotypes across the symbiosis continuum from mutualism to parasitism, including feminization (F), cytoplasmic incompatibility (CI) or male killing. Studying Wolbachia symbioses is therefore of particular interest in the investigation of symbiotic relationships.In Brugia malayi and other filarial nematodes, they are obligate leading to a loss of worm fertility, and eventual death upon their depletion with antibiotic. In arthropods, they rather are parasitic. In the isopod crustacean Armadillidium vulgare they cause feminization when present: genetic males develop as functional female leading to female biased sex-ratio progenies.In order to understand the molecular mechanisms of these two symbioses, we set up a new capture procedure to catch Wolbachia DNA and performed whole-genome sequencing on 8 Wolbachia strains, symbionts of isopods (F & CI). Comparative genomics led to the establishment of the Wolbachia pan-genome as well as the identification of phenotype related gene patterns. We identified 2, 5 and 3 genes that are only found in mutualist, feminizing and male killing strains, respectively. Expression of genes potentially involved in feminization and mutualism were also analyzed throughout host post-embryonic development. Host-symbiont interactome approach was then initiated by protein-protein interaction studies using bacterial proteins with eukaryote like motifs as bait in order to identify Wolbachia host targets involved in symbiosis
Lam, Grace. "Interactions of L. monocytogenes with Host Cellular Defenses." Thesis, 2012. http://hdl.handle.net/1807/32799.
Full textVenkatesh, Balakrishnan. "CHARACTERIZATION OF BACTERIAL LIPOPOLYSACCHARIDES (Pseudomonas syringae pv. tomato and Pseudomonas syringae pv. apii) AND PECTINS OF TOMATO AND CELERY PLANTS (Lycopersicon esculentum and Apium graveolens) REGARDING THEIR POSSIBLE ROLE IN HOST/PATHOGEN-INTERACTION." Doctoral thesis, 2002. http://hdl.handle.net/11858/00-1735-0000-0006-AC15-6.
Full textHsieh, Shang-Chen. "Swarming regulation and bacteria-host interaction in Serratia marcescens: -A novel lipoprotein SspA regulates S. marcescens swarming -2,3-butanediol, a bacterial metabolite, ameliorates acute inflammatory response induced by LPS in rat model." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1403200811054000.
Full textHsieh, Shang-Chen, and 謝尚諶. "Swarming regulation and bacteria-host interaction in Serratia marcescens:-A novel lipoprotein SspA regulates S. marcescens swarming-2,3-butanediol, a bacterial metabolite, ameliorates acute inflammatory response induced by LPS in rat model." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/89712090934927673123.
Full text臺灣大學
醫學檢驗暨生物技術學研究所
96
Swarming in Serratia marcescens is a specialized form of bacterial surface migration. S. marcescens swarms at 30 ºC but not at 37 ºC on 0.8 % LB agar plate. To unravel the underlying mechanisms of the temperature-dependent swarming behavior, transposon mutagenesis was performed to screen for mutants that swarmed at 37 ºC. SspA, a novel lipoprotein, was identified to involve the negative regulation of S. marcescens swarming at 37 ºC. Increased production of biosurfactant, over-synthesis of flagellum and the reduced biofilm formation in sspA mutant S. marcescens SC101 all might contribute to the precocious-swarming behavior of S. marcescens SC101 at 37 ºC. Furthermore, the increased hemolytic activity of precocious-swarming mutant suggested that the regulation of swarming is closely related to the pathogenesis of S. marcescens. Besides, we also asked why S. marcescens is an important nosocomial pathogen. Herein, we showed that gastric intubation of 2,3-butanediol, a pyruvate metabolite produced by S. marcescens, in rats significantly ameliorates acute lung injury and the inflammatory responses induced by S. marcescens derived endotoxin lipopolysaccharide (LPS), with an efficacy comparable to that of the polyphenol compound resveratrol. Such effect was further demonstrated to occur via modulation of the NF-κB signaling pathway. Our results indicated that bacterial metabolite, 2,3-butanediol has a negative regulatory effect on host innate immunity response, suggesting bacteria may use some metabolites for host immune evasion.
Duncan, Robert Wayne. "The host-pathogen interaction and breeding and genetics of resistance for common bacterial blight of common bean (Phaseolus vulgaris L.) caused by Xanthomonas campestris pv. phaseoli and X. c. pv. phaseoli var. fuscans." Diss., 2009. http://proquest.umi.com/pqdweb?did=1978112521&sid=1&Fmt=2&clientId=48051&RQT=309&VName=PQD.
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