Dissertations / Theses on the topic 'Hormonal'
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Hussein, Mohamed Osman. "Hormonal modulation of Leydig cell membrane luteinizing hormone receptors /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487267024995937.
Full textKirkpatrick, Bridgette Lee 1966. "Hormonal regulation of gonadotropin releasing hormone receptor expression in the ewe." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282660.
Full textRodrigues, Mark. "Hormonal and non-hormonal factors associated with cognition in post-menopausal women." University of Western Australia. School of Psychiatry and Clinical Neurosciences, 2004. http://theses.library.uwa.edu.au/adt-WU2004.0075.
Full textNyeko, Moini Brian Anyau. "Hormonal Contraceptives for men." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422360.
Full textGUENEAU, SYLVIE. "Le cancer du sein chez l'homme : approche hormonale a propos de 20 cas." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20151.
Full textLigerot, Yasmine. "Rôle des strigolactones dans le développement de l’architecture aérienne de la plante en interaction avec les autres hormones végétales." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS118/document.
Full textThe different processes of plant growth and development are under the influence of growth regulators which interact in complex hormonal networks and feedback mechanisms. The control of shoot branching involves 3 key plant hormones, auxin, cytokinins (CKs) and strigolactones (SLs). Auxin and SLs repress axillary bud outgrowth whereas CKs stimulate it. Different mechanisms of interactions between these signals have already been suggested in controlling shoot branching. Auxin controls SLs and CKs levels, and SLs and CKs pathways converge on the same target, the TCP transcription factor BRC1 in the axillary bud. In pea, the high shoot branching of ramosus (rms) mutants are known for being impaired in the SLs pathway. RMS1 (PsMAX4) and RMS5 (PsMAX3) genes are involved in SL biosynthesis while RMS3 (PsD14) (receptor) and RMS4 (PsMAX2) are involved in SL perception. In addition to sharing their high branching phenotype, the rms mutants display a dwarf phenotype. However the role of SLs in controlling plant height was unknown. Here we show that SLs control internode length by acting on cell division in a Gibberellin-independent way.The rms mutants show similar physiological characteristics: high expression of the SL-biosynthesis genes and very low xylem-sap CKs (X-CKs) content. In contrast, the rms2 mutant with similar shoot phenotype shows very low expression of SL-biosynthesis genes and high X-CKs content. Previous studies suggested that rms2 was affected in a shoot-to-root feedback signal controlling both SL biosynthesis and X-CKs level. Whether this feedback signal was auxin or not was highly discussed. Here we demonstrated that the RMS2 gene is the pea homologue of the Arabidopsis AFB4/5 gene, encoding an F-box protein which belongs to the TIR1/AFB (Auxin signaling F-Box) auxin receptor family. This suggests that the RMS2-dependent feedback signal is very likely auxin. Moreover our results suggest a role for SLs in the repression of auxin content in pea stem via the regulation of auxin metabolism gene expression. These results highlighted that for the control of shoot branching, interactions between auxin and strigolactones involve multiple mechanisms leading to regulation loop where both hormones are able to regulate the biosynthesis of each other
Isaksson, Friman Erika. "Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-182-9/.
Full textHair, W. Morton. "Studies in male hormonal contraception." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/24662.
Full textNaguib, Raouf Edouard. "Hormonal modulation of renal autoregulation." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22864.
Full textTo test the contribution of TGF resetting to the wide dynamic range of steady state autoregulation experiments, the autoregulatory range was first defined by conventional stepwise reduction of RPP. As ANG II is necessary for TGF resetting, the experiment was repeated in the presence of Losartan, a competitive ANG Il-AT$ sb1$ receptor antagonist. The results do not support the hypothesis that TGF resetting contributes to the wide dynamic range of steady state autoregulation. In fact, the lower limit of autoregulation was extended to a lower RPP. In the Losartan experiment, this shift was not apparent, suggesting that it was ANG II-dependent. (Abstract shortened by UMI.)
Kunovac, Kallak Theodora. "Hormonal Regulation of Vaginal Mucosa." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-246215.
Full textSmith, Pauline Anne. "Hormonal regulation of barnacle development." Thesis, Royal Holloway, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300467.
Full textThompson, Melissa Marie. "Males and Male Hormonal Contraception." Kent State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=kent1196792820.
Full textOliveira, Sergio Marcelino de. "Controle hormonal da próstata feminina do gerbilo sob influência de múltiplas prenhezes e reposição hormonal." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317936.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-18T04:20:43Z (GMT). No. of bitstreams: 1 Oliveira_SergioMarcelinode_D.pdf: 4535012 bytes, checksum: 94d22a407f286cbbf5f47c367a330c46 (MD5) Previous issue date: 2011
Resumo: A próstata feminina (glândula parauretral de Skene) está localizada na parede da uretra feminina e histologicamente possui as mesmas partes da próstata masculina, apresentando um epitélio colunar pseudoestratificado e componentes celulares, enzimáticos e estromais necessários para sua função exócrina e neuroendócrina. O tecido prostático possui uma alta dependência em relação aos andrógenos, e a ação destes hormônios sobre as células prostáticas é mediada via receptor nuclear. Nem todos os tipos celulares prostáticos possuem receptor para andrógenos, sugerindo que somente certos tipos celulares podem ser considerados alvos diretos da ação de andrógenos. A próstata feminina também é alvo da testosterona, pois estudos recentemente publicados demonstram que a reposição hormonal com este hormônio promove o desenvolvimento morfofuncional da próstata feminina em gerbilos. Mesmo sendo a próstata um tecido andrógeno dependente, os estrógenos são necessários para manutenção do seu funcionamento, o que se explica devido a presença dos dois tipos de receptores de estrógeno (ER- alfa e ER-?). Dados recentes da literatura propõem que os hormônios relacionados com a gravidez e ciclo ovariano promovem certo grau de proteção para o tecido da mama contra o câncer e que a aplicação de estradiol e progesterona previne a carcinogênese de mama em ratas nulíparas, mimetizando o efeito da gravidez, e ainda, que tanto o câncer de próstata quanto o câncer de mama, além de serem os principais tumores que incidem em homens e mulheres, respectivamente, e possuírem associações epidemiológicas e etiológicas, apresentam várias anormalidades genéticas em comum. O presente trabalho teve como objetivo avaliar as modificações morfo-funcionais na próstata feminina do gerbilo da Mongólia sob a influência da prenhez e avaliar a influencia desse estágio do ciclo reprodutivo na homeostase dos compartimentos prostáticos das fêmeas velhas. Para tanto, foram utilizados 50 animais, sendo: 5 fêmeas adultas nulíparas (AN); 5 fêmeas adultas multíparas (AM); 5 fêmeas velhas nulíparas (VN); 5 fêmeas velhas multíparas (VM); 5 fêmeas velhas nulíparas (VNT) e 5 velhas multíparas (VMT), as quais receberam suplementação de 0,25ml de testosterona em dias alternados (1mg/kg/dia de cipionato de testosterona em óleo vegetal) por 21 dias; 5 fêmeas velhas nulíparas (VND) e 5 velhas multíparas (VMD) as quais receberam suplementação diária de 0,1ml DHEA (5mg/kg diluída em solução salina) por 21 dias; 5 fêmeas velhas nulíparas (VNE2) e 5 velhas multíparas (VME2), as quais receberam suplementação de 0,1ml de estradiol (10mg/ml de óleo vegetal), em dias alternados, por 21 dias. O grupo VM apresentou uma maior incidência de lesões proliferativas, o que nos leva a concluir que o tecido prostático de fêmeas que passam por sucessivas gravidezes possuem maior probabilidade de serem acometidas por tais lesões. Além disso, a reposição hormonal seja com testosterona, estrógeno ou dihidrotestosterona se mostrou mais agressivo no caso de fêmeas multíparas, pois a incidência de lesões proliferativas foi maior neste grupo
Abstract: The gerbil female prostate is located paraurethrally and has all the main histological components of the male prostate, like secretor epithelium and fibromuscular stroma. This gland, like the prostate in males, is targeted by testosterone action, which promotes morphofunctional development. Furthermore, estrogens are required to maintain the male and female prostate and this gland presents both estrogen receptors (ER-alfa and ER-?). In the present work the structural and morphometric-stereological and serological aspects, as well as the quantification of the incidence, multiplicity and percentage of acini affected by different lesions were analyzed. Fifty senile female gerbils were divided into ten groups (five animals each): Adult nulliparous gerbils (AN) and adult multiparous gerbils (AM); senile nulliparous (SN) and senile multiparous (SM) female gerbils; senile nulliparous gerbils (SND) and senile multiparous gerbils (SMD) that received daily 0,1 ml of DHEA during 21 days; senile nulliparous gerbils (SNE) and senile multiparous gerbils (SME) that received 0,1 ml of ?-estradiol on alternate days during 21 days; senile nulliparous gerbils (SNT) and senile multiparous gerbils (SMT) that received 0,2ml of T (1mg/kg/day) for 21 days. This work was performed to quantify the incidence, multiplicity and percentage of acini affected by different lesions in prostate of nulliparous and multiparous senile female gerbils under different types of hormonal replacement using morphometric, stereological and immunohistochemical techniques and to try to establish a relationship between hormonal serum levels in these groups. The proliferative ratio (PCNA/TUNEL) were higher in al multiparous groups when compared with nulliparous groups, mainly in SMT, the same group where were found higher multiplicity of proliferative lesions
Doutorado
Biologia Celular
Doutor em Biologia Celular e Estrutural
Meyer, Marc-Étienne. "Les récepteurs des hormones stéroïdes entrent en compétition pour des facteurs intervenant dans leur activité transcriptionnelle." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M199.
Full textParini, Paolo. "Hormonal regulation of hepatic cholesterol and lipoprotein metabolism : effects of estrogen and growth hormone /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3372-3/.
Full textIldgruben, Anna. "Human vaginal epithelial immunity and influences of hormonal contraceptive usage." Doctoral thesis, Umeå : Klinisk mikrobiologi, enh. för Immunologi och Klin. vetenskap, obstetrik och gynekologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-595.
Full textLi, Yue-Xian. "Pulsatile hormonal signaling: a theoretical approach." Doctoral thesis, Universite Libre de Bruxelles, 1992. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212925.
Full textWalton, Melanie Jane. "Novel approaches to male hormonal contraception." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/29411.
Full textErdstein, Julius. "Hormonal regulation of experimental hepatoma growth." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65351.
Full textSherazi, Aisha. "Multiple hormonal activities of industrial chemicals." Thesis, Brunel University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324553.
Full textRiddoch, C. J. "Exercise-induced gastrointestinal symptoms : hormonal involvement." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335621.
Full textTigue, P. J. "Hormonal regulation of mammary gene expression." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381461.
Full textThomas, Charles Abidemi Adewale. "Synthetic approaches to anti-hormonal steroids." Thesis, City University London, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316056.
Full textSagor, Geoffrey Roland. "The hormonal mechanism of intestinal adaptation." Master's thesis, University of Cape Town, 1985. http://hdl.handle.net/11427/27274.
Full textGuinn, G., and D. L. Brummett. "Hormonal Changes in Relation to Cutout." College of Agriculture, University of Arizona (Tucson, AZ), 1989. http://hdl.handle.net/10150/204827.
Full textSakimin, Siti Zaharah. "Hormonal regulation of mango fruit ripening." Thesis, Curtin University, 2011. http://hdl.handle.net/20.500.11937/2008.
Full textCastelo-Branco, Flores Camil. "Efectes de la castració i del tractament hormonal sobre el perfil lipídic i hormonal de dones menopàusiques." Doctoral thesis, Universitat de Barcelona, 1992. http://hdl.handle.net/10803/2488.
Full texta) MENOPAUSA QUIRURGICA INICIAL (MQI): Les 95 primeres formen part d'un estudi prospectiu on es valora l'evolució dels perfils hormonal i lipidic al llarg dels primers mesos després d'una menopausa quirúrgica. Són doncs dones amb cicles regulars fins la cirurgia i varen controlar-se des del moment 0 de la menopausa.
b) MENOPAUSA ESPONTÀNIA (ME): Aquest grup està format per 90 dones menopàusiques amb ovaris integres. D'aquest mode es pot valorar l'efecte dels ovaris restants a la menopausa i llur producció hormonal sobre el perfil lipidic aixi com els canvis que poden induir sobre el mateix els diferents esquemes de tractament.
Aquestes 185 dones varen ser distribuides de mode homogeni i aleatori en els diversos grups de tractament (THS) i control que es descriuen més endavant segons una taula de randomització.
Els cinc regims estudiats comprenen: un grup (n=33 MQI: 18/ME: 15) pren estrògens conjugats equins (ECE) 0.625 mg/dia en cicles de 25 dies cada mes, un altre grup (n=38 MQI: 21/ME: 17) rep 17-B-estradiol transdèrmic 50 micrograms/dia en cicles de 24 dies al mes, un grup (n=32 MQI: 15/ME: 17) rep ECE 0.625 mg/dia cada dia del mes, totes aquestes pacients també reberen 2.5 mg/dia d'acetat de medroxiprogesterona sequencialment els 12 últims dies de cada cicle, el cuart grup va rebre continuadament ECE i MAP a les mateixes dosis cada dia del mes (n=39 MQI: 29/ME: 19) i l'últim grup (n=43 MQI: 21/ME: 22) fou un grup testimoni lliure de tractament.
En el primer grup de pacients (castrades quan encara tenien cicles regulars) es va determinar el perfil lipidic i hormonal previament a la cirurgia (perfil premenopàusic) i als tres mesos l'intervenció (per situar el nou perfil postmenopàusic) abans d'iniciar l'administració del THS. D'aquesta manera es va fer un "wash out" o rentat de l'estat hormonal previ i ens varem assegurar que els lípids a plasma ja no depenien del perfil hormonal anterior eren estables. A continuació es varen tornar a determinar els perfils lipidic i hormonal als 6 i 12 mesos. En l'altra subpoblació, menopausa espontània, com la menopausa és una situació ja establerta amb temps superior als tres mesos no cal fer cap "wash out" i per a iniciar el THS són prou les determinacions basals. Cal fer esment aquí que cap d'aquestes dones no havia mai rebut THS. Igual que en el cas anterior es varen determinar de nou els perfils lipídic i hormonal als 6 mesos i a l'any d'escomençat el THS.
S'ha determinat tant en les pacients tractades com en les que constituien els grups testimoni els següents perfils:
Perfil lipídic: Colesterol, HDL, LDL, Triglicèrids, Apolipoproteïna A(1), Apolipoproteïna B.
Perfil hormonal: FSH, LH, l7-B-Estradiol, Estrona, Prolactina, SHBG, Testosterona, Androstendiona, dehidroepiandrosterona-SO(4).
Els resultats de l'assaig suggereixen:
1) La dosi de 2,5 mg al dia d'acetat de medroxiprogesterona administrada seqüencialment durant 12 dies de cada cicle es insufi cient per a estalviar a l'endometri de creixements proliferatius i d'hiperplàsies (2 pacients en règim transdèrmic i 1 en oral continuat amb gestàgen seqüencial), però probablement aquesta mateixa dosi sigui segura si s'administra continuadament.
2) El THS en les pautes terapèutiques estudiades i amb els fàrmacs i dosis utilitzats no és desencadenant d'hipertensions ni agreuja les ja establertes. Tampoc pot atribuir-se al THS l'increment del pes detectat a les pacients tractades, car presenten augments de pes inferiors als detectats en els controls.
3) Amb la castració paral.lelament al descens de l'estradiol augmenten intensament les gonadotrofines i s'observa un descens dels nivells de la prolactina. També s'observen nivells significativamente més baixos de testosterona i d'androstenediona suggerint doncs un paper important de l'ovari en la síntesi d'aquests esteroïds. També en mancar l'estímul dels estrògens i en ser la relació andrògens/estrògens favorable als primers és lògic el descens de la SHBG. Tanmateix, les modificacions observades a la DHEA-S04 a les pacients després de la castració no són significatives, essent els ovaris poc rellevants a la seva síntesi.
4) Independentment del tipus de menopausa tots els tractaments són igual d'efectius en produir descensos dels nivells de les gonadotrofines i augments de l'estradiol. Paral.lelament es detecta un augment significatiu en l'estrona i SHBG en tots els grups tractats. Aquest augment és molt superior en l'estrogenoteràpia per via oral, tant que les diferències amb la transdèrmica arriben a ser significatives. El THS provoca descensos significatius de la prolactina i escases modificacions en els nivells d'andrògens (testosterona, androstenediona i DHEA-s) tant a les dones amb MQI com a les dones amb ME.
5) Amb l'ooforectomia bilateral no s'observen modificacions del colesterol total. Tanmateix en la fracció RDL hi ha un descens significatiu i en la LDL un augment significatiu en tots els grups als 3 mesos després de la cirurgia situació es manté en el grup control als 6 i 12 mesos del seguiment. Els triglicèrids després de la cirurgia no presenten canvis importants. L'apolipoproteina A-I presenta una tendència al descens que no és significativa i l'Apo B presenta canvis discrets i en sentit contrari. Amb la HQI s'observa un ascens important i significatiu de l'índex aterogènic als 3 mesos de l'ooforectomia que a l'any supera els límits recomenats (IA = 4,24). Aquests resultats indiquen que l 'ooforectomia bilateral comporta una sèrie de canvis metabòlics associats amb el risc cardivascular.
6) En el nostre estudi s'ha detectat poques modificacions amb el THS en el colesterol total però és interesant comentar també que això es degut a que els descensos de la fracció LDL s'han "compensat" amb augments paral.lels de les RDL. El THS no sembla afectar els triglicèrids de les dones de l'assaig en els règims per via oral, mentre que la via transdèrmica va presentar disminucions significatives. Amb el THS s'observa una tendència a l'augment de l'Apo A-I i al descens de l'Apo B. En la nostra sèrie els augments de l'Apo A i de l'HDL, s'observen més intensos en els grups de tractament oral continuat, fet que reforça l'hipòtesi de que sent la menopausa una situació de carència hormonal permanent, la substitució permanent presenta també avantatges a nivell metabòlic. El THS indueix als 12 mesos descensos importants en l'índex aterogènic. L'absència del THS, indueix increments al voltant o superiors al 20%. El grup d'administració continuada d'estrògens i gestàgens és el que presenta a la fi de l'estudi els valors d'índex aterogènic més baixos, donant a aquest règim terapèutic un argument més per a la seva utilització.
7) Les correlacions detectades suggereixen que l'atur del funcionament ovàric o la castració amb l'estat d'hipoestrogenèmia resultant poden ser responsables almenys en part de l'augment del colesterol i sobre tot de les LDL que és típic de les dones postmenopàusiques.
185 postmenopausal women, (95 who had undergone hysterectomy and bilateral oophorectomy -HBO- and 90 who had had natural menopause -NM-) were asked to participate in this study. Patients were allocated at random to one of 5 groups. The five different regimens comprised one group (n=33 HBO:18/NM:15) on conjugated equine estrogens (CEE) 0.625 mg/day over a 25-day cycle each month, one group (n=38 HBO:21/NM:17) on transdermal 17-B-estradiol 50 ~g/day over a 24-day cycle each month, one group (n=32 HBO:15/NM:17) on CEE 0.625 mg/day every day of the month, all these patients also received 2.5 mg/day of medroxiprogesterone acetate sequentially for the last 12 days of each cycle, the fourth group received continuously CEE and MAP at the same doses every day of the month (n=39 HBO:29/NM: 19) and the last group (n=43 HBO:21/NM:22) was a treatment free control group. Hormones (FSH, LH, E(2) , E(1), prolactine, androstendione, testosterone, DHEA-S04 , SHBG) and plasma lipids (Cholesterol, HDL, LDL, triglycerides, Apo A-I, Apo B) were determined before oophorectomy, at 3 months (prior therapy) & repeated after 6 and 12 months. Conclusions: 1) 2.5 mg/day of MAP was clearly an inadequate dose in sequential regimes to protect endometrium against hyperplasic changes, 2) HBO and NM patients showed the same trends with HRT: increases in E(2), E(l), SHBG, HDL, Apo A, decreases in FSH, LH, prolactine, Apo B, LDL, CHOL (NM), triglycerides (transdermal), and no changes in androstendione, testosterone, DHEA-So4' triglycerides (oral) and CHOL (HBO). HBO implies: increases in FSH, LH, LDL, Apo B, decreases in E(2) , E(l), SHBG, prolactine, androstendione, testosterone, HDL, Apo A, and no changes in DHEA-SO(4) triglycerides and CHOL.
Rice-McDonald, Glenn Gordon. "The hormonal influences on asthma in women /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17640.pdf.
Full textTaher, Mohammed Ahmed A. "Hormonal regulation of ATP binding cassette transporters." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971837139.
Full textHughes, Qunitin William. "Hormonal regulation of the anticoagulant Protein S." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0247.
Full textNgo, Phuong. "Hormonal regulation in early pea fruit development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0009/MQ60160.pdf.
Full textYoung, A. H. "Hormonal effects on brain 5-HT function." Thesis, University of Edinburgh, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664142.
Full textBlostein, Ashley C. "Effects of running on hormonal growth factors." Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/865946.
Full textSchool of Physical Education
Federici, Fernán. "Hormonal regulation of cell division in roots." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608578.
Full textBatarda, Marisa Alexandra Rodrigues Soares. "Tromboembolismo venoso associado à contracepção hormonal combinada." Master's thesis, Universidade da Beira Interior, 2010. http://hdl.handle.net/10400.6/751.
Full textBackground: Combined hormonal contraception (CHC) was introduced in the late 50s and in the early 60s episodes of venous thromboembolism (VTE) were reported in women using this method for contraceptive purposes. In 2003 World Health Organization (WHO) developed a graded list of recommendations according to individual risk profile of VTE, for clinicians to consider when prescribing the CHC, in order to reduce its incidence and consequences. Objectives: To assess the appropriateness of CHC prescribing according to individual risk profile of VTE. Methods: We conducted two descriptive studies in parallel. One study included 50 women using CHC, interviewed to assess their individual risk profile of VTE, according to WHO criteria. The other study, a “case series”, included all female patients hospitalized in “Centro Hospitalar da Cova da Beira (CHCB)” between 1 st July 2008 and 30th June 2009, with clinical diagnosis of VTE, to assess their history of exposure to VTE risk factors, particularly CHC. Results: Of the 50 interviewed women using CHC, 35 (70.0%) had risk factors for VTE. Of these, 10 (20.0%) had a risk profile for VTE classified in WHO category 3 or 4. When asked about their knowledge of different risk factors of VTE associated with CHC use, 27 women (54.0%) knew that varicose veins increase the risk of VTE. Respondents with identified risk factors knew it in 33 cases. The 25 women (50.0%) in WHO categories 1 and 2 had a “CHC prescription adjusted to individual risk profile of VTE”. From those belonging to WHO categories 3 and 4, 9 women (18.0%) had a “CHC prescription not adjusted to individual risk profile of VTE”. Conclusions: The prescription of CHC is not always appropriated to the individual risk profile of VTE. Women are not properly informed of this risk, and those who are sometimes are not receptive to alternative methods of contraception. Clinicians should be aware of the need for improving care and adjust CHC prescribing to individual risk profile of VTE, although in absolute terms the impact of the use of CHC in VTE episodes is small.
CLAVEAU, CHRISTOPHE. "Metastases surrenaliennes des carcinomes et retentissement hormonal." Angers, 1990. http://www.theses.fr/1990ANGE1022.
Full textJanssens, Markus Peter-Erik. "Hormonal control of flight metabolism in Odonata?" Master's thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/21424.
Full textBAUMANN, BILLMANN VALERIE. "Traitement hormonal substitutif lors de la menopause." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR15002.
Full textCharles, Nora. "Hormonal influences on sex-linked sexual attitudes." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2820.
Full textSukiran, Nur Afiqah Binti. "Exploring plant hormonal signalling through chemical perturbation." Thesis, Durham University, 2018. http://etheses.dur.ac.uk/12625/.
Full textHalson, Shona L. "Performance, metabolic and hormonal alterations during overreaching." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/15790/1/Shona_Halson_Thesis.pdf.
Full textHalson, Shona L. "Performance, metabolic and hormonal alterations during overreaching." Queensland University of Technology, 2003. http://eprints.qut.edu.au/15790/.
Full textKido, Larissa Akemi 1988. "Terapias antiangiogênicas, uso de Finasterida e resposta hormonal na próstata de camundongos senis." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/318025.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: A senescência está associada a mudanças significativas no ambiente hormonal, sendo fator causador de alterações morfofuncionais na próstata. Os diferentes processos biológicos que ocorrem na próstata são regulados por polipeptídeos, dentre esses os fatores de crescimento do endotélio vascular (VEGF) e Endostatina, relacionados à angiogênese. Além disso, inibidores da enzima 5_ redutase-II, como a finasterida, tem papel importante no combate às doenças prostáticas. Assim, os principais objetivos desse estudo foram avaliar os efeitos estruturais e moleculares das terapias antiangiogênicas e da finasterida sobre a próstata ventral de camundongos durante a senescência. Noventa camundongos machos FVB de 18 e 52 semanas de idade foram divididos nos seguintes grupos: Jovem (JV) e Senil (SEN), os quais receberam injeções de Solução Fisiológica 0,9% (5 mL/Kg/dia s.c.); Finasterida (FIN): injeções de Finasterida (20 mg/Kg, s.c.); SU5416 (SU): SU5416 (6 mg/Kg, i.p.); TNP-470 (TNP): injeções de TNP-470 (15 mg/Kg, s.c.), e SU5416 + TNP-470 (SU+TNP): os mesmos tratamentos dos grupos SU e TNP. Após 21 dias de tratamento, amostras do lobo ventral da próstata foram coletadas e submetidas às análises morfológicas, imunohistoquímicas e Western Blotting. Os resultados demonstraram alterações moleculares e estruturais no microambiente prostático durante a senescência, como atrofia presença de células inflamatórias, e lesões proliferativas, as quais foram interrompidas e ou bloqueadas através dos tratamentos com as drogas antiangiogênicas e pela finasterida. Os resultados moleculares revelaram no grupo senil a diminuição das reatividades para AR e Endostatina, e aumento para ER-_, ER-_ e VEGF, quando comparados aos camundongos jovens. Os camundongos dos grupos tratados com finasterida, SU5416 e SU5416+TNP-470, quando comparados aos do grupo senil, demonstraram de forma geral diminuição das reatividades de VEGF e ER-_ e aumento de ER-_. Já o tratamento com TNP-470 foi marcado principalmente pela redução da reatividade e dos níveis protéicos de AR e ER-_, quando comparado aos grupos jovem e senil. Desta maneira, conclui-se que a senescência favoreceu a ocorrência de alterações estruturais e/ ou funcionais que sugerem o aparecimento de lesões malignas, em virtude do desequilíbrio na sinalização entre epitélio e estroma. O tratamento com finasterida, SU5416 e SU5416+TNP- 470 mostraram-se mais ativos na regulação dos processos proliferativos através da via estrogênica
Abstract: Senescence is associated with significant changes in the hormonal environment and is a cause of morphological and functional changes in the prostate. The different biological processes that occur in the prostate are influenced by different factors such as vascular endothelial growth factor (VEGF) and Endostatin, related to angiogenesis. Also, 5_-reductase inhibitors, such as finasteride, play an important role in treatment of prostatic diseases. Thus, the aims of this study were to evaluate the structural and molecular effects of antiangiogenic therapies and finasteride on the ventral prostate of mice during senescence. Ninety 52 and 18 week old male FVB mice, were divided into groups: Young (YNG) and Senile (SEN) groups, which received 0.9% saline (5 mL/kg/day sc) injections; Finasteride (FIN) group: Finasteride (20 mg/kg, sc); SU5416 (SU) group: SU5416 (6 mg/kg, ip) injections; TNP-470 (TNP) group: TNP-470 (15 mg/kg, sc) injections and SU5416+TNP-470 (SU+TNP470) group: The same treatment as the SU and TNP-470 groups. After 21 days of treatment, samples of the ventral lobe of the prostate were collected and analyzed for morphological, immunohistochemical and Western Blotting analyses. The results demonstrated structural and molecular changes in the prostatic microenvironment during senescence, such as atrophy, inflammatory cells, and proliferative lesions, which were interrupted and/or blocked by treatment with antiangiogenic drugs and finasteride. The molecular results revealed decreased reactivity for AR and Endostatin, and an increase for ER-_, ER-_ and VEGF in the senile group, when compared to young mice. The mice in the groups treated with finasteride, SU5416 and SU5416 + TNP-470, when compared to the senile group, showed in general decreased VEGF and ER-_ reactivities and increased ER-_ reactivity. The treatment with TNP-470 however, was marked mainly by reduced AR and ER-_ reactivity and protein levels, when compared to young and senile groups. Thus, it can be concluded that senescence contributed to the occurrence of structural and/or molecular alterations that suggest the onset of malignant lesions, due to the imbalance in the signaling between the epithelium and stroma. Treatments with finasteride, SU5416 and SU5416+TNP-470, were active in the regulation of proliferative processes by means of the estrogen pathways
Mestrado
Anatomia
Mestra em Biologia Celular e Estrutural
Villar, David. "Hormonal regulation of the fibre growth and moult cycle in cashmere goats." Thesis, University of Aberdeen, 1998. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU106170.
Full textMaciel, Luciana França Smith. "Expressão dos receptores endometriais de estrógeno e progesterona em éguas acíclicas após administração de progesterona." Botucatu, 2017. http://hdl.handle.net/11449/151275.
Full textResumo: Progesterone (P4) is frequently used after the administration of estradiol, to prepare seasonal non-cyclic mares as embryo recipients, however previous studies have reported gestation of seasonal non-cyclic mares treated only with P4. The objective of the present study was to evaluate the gene and protein expression of estrogen receptor alpha (ERα), estrogen beta (ERβ) and progesterone (PR) in the endometrium of seasonal non-cyclic mares treated with long acting progesterone (LAP4). Eight mares were used during the seasonal anoestrus phase, uterine biopsies were performed immediately before and five days after administration of 1,5 g of LA P4. Blood samples were taken daily for the determination of plasma P4 concentration. The protein expression of the receptors was evaluated by the immunohistochemistry and the immunostaining area percentage was determined by the ImageJ software. Transcripts abundance for ERα (ESR1), ERβ (ESR2) and PR (PGR) were determined by RT-qPCR. ERα showed higher protein expression (p <0.05) after administration of P4LA, but there was no change in mRNA abundance encoding this gene (p> 0,05). Tendency to lower protein expression was observed (p=0,07) and gene expression inhibition (p <0,05) for ERβ, PR did not changes (p>0,05). The plasma concentration of P4 presented a higher concentration 24 hours after the application of LA P4 (D1), with subsequent decline in these values (p<0,05). The 1.5 g dose of LA P4 reached the minimum concentrations of P4 requi... (Resumo completo, clicar acesso eletrônico abaixo)
Mestre
Mohammad, Helai P. "CHARACTERIZATION OF THE HORMONAL REQUIREMENTS AND MOLECULAR MECHANISMS THAT UNDERLIE PITUITARY TUMORIGENESIS IN MICE OVEREXPRESSING LUTEINIZING HORMONE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=case1080073606.
Full textScarano, Wellerson Rodrigo. "Repercussões histopatologicas na prostata ventral do gerbilo da Mongolia (Merinones unguiculatus) apos suplementação por hormonios esteroides." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317918.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: O tecido prostático é susceptível aos desníveis hormonais provocados, principalmente pelo processo de envelhecimento. A hiperplasia benigna prostática e o câncer de próstata são doenças que acometem uma grande parcela da população masculina, e parecem estar envolvidas com alterações hormonais. Por isso, o esclarecimento dos processos celulares e teciduais envolvendo os hormônios sexuais: testosterona e estradiol são, sem dúvida, importantes para o entendimento da etiologia desses processos patológicos. O gerbilo (Meriones unguiculatus) foi utilizado como modelo experimental pois, segundo a literatura, é susceptível ao aparecimento de lesões autóctones e responde bem à carcinogênese experimental, mostrando-se um bom modelo experimental. Numa primeira etapa, foram utilizados animais de três idades diferentes: púbere, adulta e senil. Esses animais foram submetidos à suplementação androgênica e as próstatas ventrais foram destinadas a análises histopatológicas, quantitativas, imunocitoquímicas e ultraestruturais. Foi observado aumento no peso da glândula e também na altura das células epiteliais em todas as idades. Tal aumento reflete o aumento da capacidade sintética observada pela dilatação das organelas de síntese, às vezes de aspecto vesiculoso, ocupando toda a região supranuclear. Nos animais adultos e velhos foram notadas regiões hiperplásicas e displásicas freqüentemente associadas a Neoplasias Intraepiteliais de diferentes graus e a adenocarcinomas. Houve aumento na espessura da camada de células musculares lisas (CML) ao redor dos ácinos nos animais púberes e adultos, enquanto nos animais velhos houve diminuição dessa camada. Além disso, as CML se mostraram aparentemente hipertróficas e com maior atividade sintética nos animais púberes e adultos. Foi notado aparente aumento da vascularização periacinar, onde se observou a presença de freqüentes vasos sanguíneos em todas as idades após o tratamento. Ademais, em todas as idades foi observado aumento da densidade de marcação de receptores androgênicos após o tratamento, evidenciando a possível relação desses receptores com os efeitos observados. Em uma segunda etapa experimental, avaliou-se o efeito do estradiol sobre o tecido prostático intacto e hipoandrogênico em animais adultos, tentando com isso simular situações de descompensação hormonal, típicas da senilidade. As alterações epiteliais foram freqüentes nos animais tratados com estradiol onde se observou aumento na altura das células epiteliais, aparecimento de regiões de intensa displasia e hiperplasia, e a formação de PINs. Outro aspecto que independe da presença da testosterona é o arranjo dos elementos fibrilares e não fibrilares da matriz extracelular entre as CML, apontando para um possível papel dessas células no rearranjo e na síntese desses componentes após os tratamentos estrogênicos. Nos animais castrados observou-se acúmulo de elementos da matriz extracelular sob o epitélio e em animais intactos presença desses elementos dispersos e escassos. Em ambos os grupos: intactos e castrados, notou-se que as CML e os fibroblastos apresentam fenótipo secretor acentuado após o tratamento com estradiol. Houve aumento na densidade de marcação ERa e AR positivos em regiões de hiperplasia apontando para um possível papel desses receptores na formação de lesões pré-malígnas e malignas. Portando, conclui-se que o gerbilo é susceptível a ação da testosterona e do estradiol, os quais provocam desarranjos estruturais e ultraestruturais de cunho patológico e funcional, mostrando-se um ótimo modelo para o estudo das doenças prostáticas de etiologia hormonal
Abstract: Not informed.
Doutorado
Biologia Celular
Doutor em Biologia Celular e Estrutural
Welsh, Shayne. "Hormonal control of wood formation in radiata pine." Thesis, University of Canterbury. Biological Sciences, 2006. http://hdl.handle.net/10092/968.
Full textRenlund, Nina. "Hormonal and paracrine influences on Leydig cell steroidogenesis /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-842-8/.
Full textSchoneveld, Jan Leonard Martin. "The hormonal regulation of carbamoylphosphate synthetase I expression." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/76536.
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