Academic literature on the topic 'Hormesis'
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Journal articles on the topic "Hormesis"
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Rattan, Suresh IS, and Taru Deva. "Testing the hormetic nature of homeopathic interventions through stress response pathways." Human & Experimental Toxicology 29, no. 7 (June 17, 2010): 551–54. http://dx.doi.org/10.1177/0960327110369858.
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The scientific foundations of hormesis are now well established and include various biochemical and molecular criteria for testing the hormetic nature of chemicals and other modulators. In order to claim homeopathy as being hormetic, it is essential that, in addition to the hormetic biphasic dose response, homeopathic remedies should fulfill one or more molecular criteria. Since stress response pathways, such as heat shock response, antioxidative response, autophagic response and unfolded protein response, are integral components of the physiological hormesis, it is important that homeopathic drugs be tested for these pathways if these are to be considered as hormetins and to cause hormesis.
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Kitchin, Kirk T., and J. Wanzer Drane. "A critique of the use of hormesis in risk assessment." Human & Experimental Toxicology 24, no. 5 (May 2005): 249–53. http://dx.doi.org/10.1191/0960327105ht520oa.
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There are severe problems and limitations with the use of hormesis as the principal dose-response default assumption in risk assessment. These problems and limitations include: (a) unknown prevalence of hormetic doseresponse curves; (b) random chance occurrence of hormesis and the shortage of data on the repeatability of hormesis; (c) unknown degree of generalizability of hormesis; (d) there are dose-response curves that are not hormetic, therefore hormesis cannot be universally generalized; (e) problems of post hoc rather than a priori hypothesis testing; (f) a possible large problem of ‘false positive’ hormetic data sets which have not been extensively replicated; (g) the ‘mechanism of hormesis’ is not understood at a rigorous scientific level; (h) in some cases hormesis may merely be the overall sum of many different mechanisms and many different dose-response curves - some beneficial and some toxic. For all of these reasons, hormesis should not now be used as the principal dose-response default assumption in risk assessment. At this point, it appears that hormesis is a long way away from common scientific acceptance and wide utility in biomedicine and use as the principal default assumption in a risk assessment process charged with ensuring public health protection.
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Borak, Jonathan, and Greg Sirianni. "Hormesis: Implications for Cancer Risk Assessment." Dose-Response 3, no. 3 (May 1, 2005): dose—response.0. http://dx.doi.org/10.2203/dose-response.003.03.011.
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Current guidelines for cancer risk assessment emphasize a toxicant's “mode of action”, rather than its empirically derived dose-response relationship, for determining whether linear low-dose extrapolation is appropriate. Thus, for reasons of policy, demonstration of hormesis is generally insufficient to justify a non-linear approach, although it may provide important insights into the actions of toxicants. We evaluated dose-response characteristics of four carcinogens reported to have hormetic dose-response curves: cadmium chloride; ionizing radiation; PAHs; and, 2,3,7,8-TCDD. For each, the study that documented hormesis in one organ also provided evidence of non-hormetic dose-responses in other organs or non-hormetic responses for seemingly similar carcinogens in the same species and organs. Such inconsistency suggests toxicologic reasons that the finding of hormesis alone is not sufficient to justify use of non-linear low-dose extrapolations. Moreover, available data in those examples are not sufficient to know whether hormesis is a property of the toxicants, the target organ, or the exposed species. From the perspectives of cancer risk assessment, the greatest informational value of hormesis may be that it provokes mechanistic studies intended to explain why hormesis occurs.
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Greenwood, Sharon N., Regina G. Belz, and Brian P. Weiser. "A Conserved Mechanism for Hormesis in Molecular Systems." Dose-Response 20, no. 3 (July 2022): 155932582211093. http://dx.doi.org/10.1177/15593258221109335.
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Hormesis refers to dose-response phenomena where low dose treatments elicit a response that is opposite the response observed at higher doses. Hormetic dose-response relationships have been observed throughout all of biology, but the underlying determinants of many reported hormetic dose-responses have not been identified. In this report, we describe a conserved mechanism for hormesis on the molecular level where low dose treatments enhance a response that becomes reduced at higher doses. The hormetic mechanism relies on the ability of protein homo-multimers to simultaneously interact with a substrate and a competitor on different subunits at low doses of competitor. In this case, hormesis can be observed if simultaneous binding of substrate and competitor enhances a response of the homo-multimer. We characterized this mechanism of hormesis in binding experiments that analyzed the interaction of homotrimeric proliferating cell nuclear antigen (PCNA) with uracil DNA glycosylase (UNG2) and a fluorescein-labeled peptide. Additionally, the basic features of this molecular mechanism appear to be conserved with at least two enzymes that are stimulated by low doses of inhibitor: dimeric BRAF and octameric glutamine synthetase 2 (GS2). Identifying such molecular mechanisms of hormesis may help explain specific hormetic responses of cells and organisms treated with exogenous compounds.
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Calabrese, Edward J., and Linda A. Baldwin. "The Dose Determines the Stimulation (and Poison): Development of A Chemical Hormesis Database." International Journal of Toxicology 16, no. 6 (November 1997): 545–59. http://dx.doi.org/10.1080/109158197226874.
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A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant articles were retrieved from preliminary computer searches utilizing various keyword descriptors and extensive cross-referencing. A priori evaluation criteria were established including study design features (e.g., number of doses, dose range), statistical analysis, and reproducibility of results. Evidence of chemical hormesis was judged to have occurred in approximately 350 of the 4000 studies evaluated. Chemical hormesis was observed in a wide range of taxonomic groups and involved agents representing highly diverse chemical classes, many of potential environmental relevance. Numerous biologic endpoints were assessed, with growth responses the most prevalent, followed by metabolic effects, longevity, reproductive responses, and survival. Hormetic responses were generally observed to be of limited magnitude with the average low-dose maximum stimulation approximately 50% greater than controls. The hormetic dose-response range was generally limited to about one order of magnitude with the upper end of the hormetic curve approaching the estimated no-observed-effect level (NOEL) for the particular endpoint. Based on the evaluation criteria, high to moderate evidence of hormesis was observed in studies comprised of ≥ doses with <3 doses in the hormetic zone. The present analysis suggests that chem ical hormesis is a reproducible and generalizable biologic phenomenon. Over the last decade advances have been made providing mechanistic insight helpful in explaining the phenomenon of chemical hormesis in multiple biologic systems with various endpoints. The reason for the uncertainty surrounding the existence of hormesis as a “real phenomenon” is believed to be the result of its relatively infrequent observation in the literature due to experimental design considerations, especially with respect to the number of doses, range of doses, and endpoint selection.
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Calabrese, E. J., and L. A. Baldwin. "Radiation hormesis: the demise of a legitimate hypothesis." Human & Experimental Toxicology 19, no. 1 (January 2000): 76–84. http://dx.doi.org/10.1191/096032700678815611.
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This paper examines the underlying factors that contributed to the marginalization of radiation hormesis in the early and middle decades of the 20th century. The most critical factor affecting the demise of radiation hormesis was a lack of agreement over how to define the concept of hormesis and quantitatively describe its dose-response features. If radiation hormesis had been defined as a modest overcompensation to a disruption in homeostasis as would have been consistent with the prevailing notion in the area of chemical hormesis, this would have provided the theoretical and practical means to blunt subsequent legitimate criticism of this hypothesis. A second critical factor undermining the radiation hormesis hypothesis was the generally total lack of recognition by radiation scientists of the concept of chemical hormesis which was markedly more advanced, substantiated and generalized than in the radiation domain. The third factor was that major scientific criticism of low dose stimulatory responses was galvanized at the time that the National Research Council (NRC) was organizing a national research agenda on radiation and the hormetic hypothesis was generally excluded from the future planned research opportunities. Furthermore, the criticisms of the leading scientists of the 1930s which undermined the concept of radiation hormesis were limited in scope and highly flawed and then perpetuated over the decades by other ‘prestigious’ experts who appeared to simply accept the earlier reports. This setting was then linked to a growing fear of radiation as a cause of birth defects, mutation and cancer, factors all reinforced by later concerns over the atomic bomb. Strongly supportive findings on hormetic effects in the 1940s by Soviet scientists were either generally not available to US scientists or disregarded as part of the Cold War mindset without adequate analysis. Finally, a massive, but poorly designed, US Department of Agriculture experiment in the late 1940s to assess the capacity for low dose plant stimulation by radionuclides failed to support the hormetic hypothesis thereby markedly lessening enthusiasm for research and funding in this area. Thus, the combination of a failed understanding of the hormetic hypothesis and its linkage with a strong chemical hormesis database, flawed analyses by prestigious scientists at the critical stage of scientific research development, reinforced by a Cold War mentality led to marginalization of an hypothesis (i.e., radiation hormesis) that had substantial scientific foundations and generalizability.
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Agathokleous, Evgenios, Costas Saitanis, and Athina Markouizou. "Hormesis Shifts the No-Observed-Adverse-Effect Level (NOAEL)." Dose-Response 19, no. 1 (January 1, 2021): 155932582110016. http://dx.doi.org/10.1177/15593258211001667.
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Data from recent dose-response toxicological studies suggest that the no-observed-adverse-effect-level (NOAEL) may depend upon whether hormesis is present. A further examination of these data supports this hypothesis by showing that the NOAEL was greater for living units (organisms or cells) showing hormesis than for living units showing no hormesis. For example, some cancer tissue cells may exhibit hormetic responses to an anticancer drug while some other cancer tissue cells may not. These findings suggest that living units showing hormesis may also be less susceptible than living units not showing hormesis. However, these findings are preliminary and cannot be generalized or assumed to be a norm yet. New studies are needed to evaluate how NOAEL shifts depending on the occurrence of hormesis.
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Pickrell, John A., and Frederick W. Oehme. "Examining the risks and benefits of replacing traditional dose-response with hormesis." Human & Experimental Toxicology 24, no. 5 (May 2005): 259–64. http://dx.doi.org/10.1191/0960327105ht521oa.
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In responding to Drs Calabrese and Baldwin's question, ‘At what point, if ever, should hormesis be employed as the principal dose response default assumption in risk assessment?’, we examined the benefits of replacing traditional dose-response with hormesis. In general, hormesis provides more complete useful information for risk assessment than does traditional dose-response. A major limitation of using hormesis as a default assumption in risk estimation is the difficulty of differentiating complex low-level hormetic responses from the placebo effect. A second limitation is that hormesis merely further defines one response. Most toxicoses have many responses. The most complete information takes all responses and their connections into account.
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Calabrese, E. J., and L. A. Baldwin. "The marginalization of hormesis." Human & Experimental Toxicology 19, no. 1 (January 2000): 32–40. http://dx.doi.org/10.1191/096032700678815594.
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Despite the substantial development and publication of highly reproducible toxicological data, the concept of hormetic dose-response relationships was never integrated into the mainstream of toxicological thought. Review of the historical foundations of the interpretation of the bioassay and assessment of competitive theories of dose-response relationships lead to the conclusion that multiple factors contributed to the marginalization of hormesis during the middle and subsequent decades ofthe 20th century. These factors include: (a) the close-association of hormesis with homeopathy lead to the hostility of modern medicine toward homeopathy thereby creating a guilt by association framework, and the carry-over influence of that hostility in the judgements of medically-based pharmacologists/ toxicologists toward hormesis; (b) the emphasis of high dose effects linked with a lack of appreciation of the significance of the implications of low dose stimulatory effects; (c) the lack of an evolutionary-based mechanism(s) to account for hormetic effects; and (d) the lack of appropriate scientific advocates to counter aggressive and intellectually powerful critics of the hormetic perspective.
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Calabrese, Edward J., Gaurav Dhawan, Rachna Kapoor, Ivo Iavicoli, and Vittorio Calabrese. "HORMESIS: A Fundamental Concept with Widespread Biological and Biomedical Applications." Gerontology 62, no. 5 (November 5, 2015): 530–35. http://dx.doi.org/10.1159/000441520.
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Hormesis is a biphasic dose response with specific quantitative features for the amplitude and width of the stimulation. It is highly generalizable and independent of biological model, endpoint, inducing agent, level of biological organization and mechanism. Hormesis may be induced via a direct stimulation or by overcompensation to a disruption of homeostasis. The induction of hormesis by low-level stressor agents not only rapidly upregulates adaptive processes to repair damage but also protects the adapted system from damage due to a subsequent challenging dose (toxic) within a definable temporal window. The striking consistency of the amplitude of hormetic response suggests that hormesis provides a quantitative description of biological plasticity. Knowledge of hormesis has particular potential biomedical significance with respect to slowing or retarding both normal aging processes and the progression of severe neurological diseases.
Dissertations / Theses on the topic "Hormesis"
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Silva, Ferdinando Marcos Lima [UNESP]. "Hormesis de herbicidas em soja." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/110940.
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000791298.pdf: 1255629 bytes, checksum: 167ceaa2fd11583895b9a2aee9dab019 (MD5)O efeito benéfico de subdoses de substâncias tóxicas é conhecido há muito tempo e este fenômeno é chamado de hormesis. Em agricultura, muitos são os casos de herbicidas que em doses normais causam severas injurias nas plantas, mas que em doses muito baixas promovem o crescimento de estruturas das plantas ou promovem outros efeitos benéficos, como aumento do teor de proteína em plantas. Objetivou-se com este trabalho avaliar o efeito de hormesis dos herbicidas glyphosate, amicarbazone, mesotrione, imazapic e carfentrazone em soja, além de explorar se o efeito de hormesis na soja é afetado por um pré-tratamento com baixas doses de glyphosate e mais tarde exposta as mesmas doses ou doses maiores. Para isso, três experimentos distintos foram conduzidos, sendo que no primeiro, sete doses do herbicida glyphosate (0; 1,8; 3,6; 7,2; 36; 180 e 720 g e.a.ha-1 ) foram aplicadas sobre as plantas de soja e avaliadas quanto à taxa de transporte de elétrons (ETR), acúmulo de compostos químicos alterados em função da ação do glyphosate (ácido chiquímico, ácido benzoico, ácido salicílico, AMPA, fenilalanina, tirosina e triptofano) e massa de matéria seca das plantas. No segundo experimento, foi feito um pré-tratamento das plantas com subdoses do glyphosate (0; 1,8; 3,6 e 7,2 g e.a. ha-1 ) no estádio V2 e 14 dias após esta aplicação, as plantas receberam uma segunda aplicação de diferentes doses do glyphosate (0; 1,8; 3,6; 7,2; 36; 180 e 720 g e.a. ha-1 ) e posteriormente avaliadas quanto ao acúmulo de massa de matéria seca e ácido chiquímico. No terceiro experimento, foram testadas uma completa curva de dose-resposta dos herbicidas amicarbazone, ...
The beneficial effect of low doses of toxic substances is known a long time and this phenomenon is called hormesis. In agriculture, there are many cases of herbicides that in normal rates cause severe injuries in plants, but in very low doses promote the growth of plant structures or other beneficial effect such as increase in the protein content in plants. The objective of this study was to evaluate the effect of hormesis of glyphosate, amicarbazone, mesotrione, imazapic and carfentrazone in soybean, in addition to exploring if the effect of hormesis in soybeans is affected by a pretreatment with low doses of glyphosate and later expose to the same doses or higher. For this, three separate experiments were carried out, and on the first one seven doses of glyphosate (0; 1.8; 3.6; 7.2; 36; 180 and 720 g a.e.ha-1 ) were applied to the soybean plants and evaluated the electron transport rate (ETR), the chemical compounds resulting from the action of glyphosate (shikimic acid, benzoic acid, salicylic acid, AMPA , phenylalanine, tyrosine and tryptophan) and hormesis effect on the dry weight of plants. The second experiment was made a pretreatment of soybean plants with low doses of glyphosate (0; 1.8; 3.6 and 7.2 g a.e.ha-1) in the V2 stage and 14 days later the plants received a second application of different doses of glyphosate (0; 1.8; 3.6; 7.2; 36; 180 e 720 g a.e.ha-1 ) and subsequently evaluated the dry weight of plants and shikimic acid. In the third experiment, was tested a full dose-response of the herbicides amicarbazone, mesotrione, imazapic and carfentrazone on soybean plants and evaluated the ETR and dry weight. The results indicated that at low doses glyphosate stimulated ETR and increased biomass. The compounds from shikimic acid pathway such as benzoic and salicylic acids had respective increases of 203 and 170% in the dose of 3.6 g a.e. ha-1of glyphosate and the amino ...
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Silva, Ferdinando Marcos Lima 1981. "Hormesis de herbicidas em soja /." Botucatu :, 2014. http://hdl.handle.net/11449/110940.
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Orientador: Edivaldo Domingues VeliniCoorientador: Stephen O.Duke
Coorientador: Franck E.Dayan
Banca: Caio Antonio Carbonari
Banca: Antonio Luiz Cerdeira
Banca: Marcelo de Almeda Silva
Banca: Sidnei Douglas Cavalieri
Resumo: O efeito benéfico de subdoses de substâncias tóxicas é conhecido há muito tempo e este fenômeno é chamado de hormesis. Em agricultura, muitos são os casos de herbicidas que em doses normais causam severas injurias nas plantas, mas que em doses muito baixas promovem o crescimento de estruturas das plantas ou promovem outros efeitos benéficos, como aumento do teor de proteína em plantas. Objetivou-se com este trabalho avaliar o efeito de hormesis dos herbicidas glyphosate, amicarbazone, mesotrione, imazapic e carfentrazone em soja, além de explorar se o efeito de hormesis na soja é afetado por um pré-tratamento com baixas doses de glyphosate e mais tarde exposta as mesmas doses ou doses maiores. Para isso, três experimentos distintos foram conduzidos, sendo que no primeiro, sete doses do herbicida glyphosate (0; 1,8; 3,6; 7,2; 36; 180 e 720 g e.a.ha-1 ) foram aplicadas sobre as plantas de soja e avaliadas quanto à taxa de transporte de elétrons (ETR), acúmulo de compostos químicos alterados em função da ação do glyphosate (ácido chiquímico, ácido benzoico, ácido salicílico, AMPA, fenilalanina, tirosina e triptofano) e massa de matéria seca das plantas. No segundo experimento, foi feito um pré-tratamento das plantas com subdoses do glyphosate (0; 1,8; 3,6 e 7,2 g e.a. ha-1 ) no estádio V2 e 14 dias após esta aplicação, as plantas receberam uma segunda aplicação de diferentes doses do glyphosate (0; 1,8; 3,6; 7,2; 36; 180 e 720 g e.a. ha-1 ) e posteriormente avaliadas quanto ao acúmulo de massa de matéria seca e ácido chiquímico. No terceiro experimento, foram testadas uma completa curva de dose-resposta dos herbicidas amicarbazone, ...
Abstract: The beneficial effect of low doses of toxic substances is known a long time and this phenomenon is called hormesis. In agriculture, there are many cases of herbicides that in normal rates cause severe injuries in plants, but in very low doses promote the growth of plant structures or other beneficial effect such as increase in the protein content in plants. The objective of this study was to evaluate the effect of hormesis of glyphosate, amicarbazone, mesotrione, imazapic and carfentrazone in soybean, in addition to exploring if the effect of hormesis in soybeans is affected by a pretreatment with low doses of glyphosate and later expose to the same doses or higher. For this, three separate experiments were carried out, and on the first one seven doses of glyphosate (0; 1.8; 3.6; 7.2; 36; 180 and 720 g a.e.ha-1 ) were applied to the soybean plants and evaluated the electron transport rate (ETR), the chemical compounds resulting from the action of glyphosate (shikimic acid, benzoic acid, salicylic acid, AMPA , phenylalanine, tyrosine and tryptophan) and hormesis effect on the dry weight of plants. The second experiment was made a pretreatment of soybean plants with low doses of glyphosate (0; 1.8; 3.6 and 7.2 g a.e.ha-1) in the V2 stage and 14 days later the plants received a second application of different doses of glyphosate (0; 1.8; 3.6; 7.2; 36; 180 e 720 g a.e.ha-1 ) and subsequently evaluated the dry weight of plants and shikimic acid. In the third experiment, was tested a full dose-response of the herbicides amicarbazone, mesotrione, imazapic and carfentrazone on soybean plants and evaluated the ETR and dry weight. The results indicated that at low doses glyphosate stimulated ETR and increased biomass. The compounds from shikimic acid pathway such as benzoic and salicylic acids had respective increases of 203 and 170% in the dose of 3.6 g a.e. ha-1of glyphosate and the amino ...
Doutor
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Pincelli-Souza, Renata Passos [UNESP]. "Hormesis de glyphosate em cana-de-açúcar." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/123371.
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000829242.pdf: 1188008 bytes, checksum: e8313c70630f863d077738ad066ecdea (MD5)Atualmente, tanto no setor de produção agrícola quanto nas diversas áreas da saúde humana, o efeito de subdoses de produtos aplicados, denominado como hormótico, vem sendo amplamente discutido e pesquisado, com o objetivo de compreender o mecanismo de ação estimulante e benéfica de diversas substâncias inicialmente consideradas como tóxicas, quando aplicadas em doses elevadas. O objetivo desta pesquisa foi verificar o efeito hormótico da subdose do herbicida glyphosate nas variáveis morfológicas, fisiológicas e a produção final de cana-de-açúcar. Os experimentos foram plantados em novembro de 2010 na Unidade de Pesquisa e Desenvolvimento de Jaú, SP, da APTA Pólo Centro-Oeste/SAA, conduzidos e avaliados durante o ciclo de cana-de-ano em cana-planta. A variedade utilizada foi a SP80-1842. Os tratamentos foram constituídos pela aplicação ou não de subdose de glyphosate. A aplicação dos tratamentos foi aos 70 dias após o plantio (DAP) e a subdose utilizada foi de 1,8 g e a ha-1 de glyphosate. No primeiro experimento foi avaliado o crescimento e desenvolvimento da cultura da cana-de-açúcar em parcelas de três linhas de plantio por três metros, nas quais foram coletadas um metro linear para avaliações em oito épocas, isto é, 70, 105, 140, 175, 210, 245, 280 e 315 dias após o plantio, em um delineamento de blocos casualizados com seis repetições. No segundo experimento, avaliou-se produtividade de colmos e de açúcar, foram utilizadas parcelas de cinco linhas de plantio por oito metros foram dispostas blocos casualizados com seis repetições, e coletadas ao final do ciclo da cultura, ou seja, aos 315 DAP. Em cada época de amostragem, do primeiro experimento, foram avaliados conteúdo de ácido chiquímico, ácido quínico, glyphosate e ácido aminometilfosfônico, teores de ...
Currently, both in agricultural production and in areas of human health sector, the low dose effect of products applied, termed as hormetic, has been widely debated and researched in order to understand the mechanism of stimulating and beneficial action of several substances initially considered as toxic, when applied in high doses. The objective of this research was to investigate the effect of low dose of glyphosate on growth, phosphorus accumulation in the shoot, the production of shikimic and quinic acid, and final yield of sugarcane. The experiments were planted on November 05, 2010 in Research and Development Unit of Jaú, SP, APTA Polo Midwest / SAA, and carried out and evaluated over the course of the year in sugarcane plant cane. The variety used was SP80-1842. Two experiments were carried out to evaluate the effect hormetic during growth and development of sugarcane and cane yield and sugar. The treatments consisted at application or not of low dose of glyphosate. The spraying was at 70 DAP and the low dose dose used was 1.8 g a e ha-1 glyphosate. In the first experiment evaluated the growth and development of the sugar cane crop in portions of three planting rows of three meters, in which it was collected a linear meter for evaluations in eight times, or , 70, 105, 140, 175, 210, 245, 280 and 315 days after planting, in a randomized block design with six replications. In the second experiment, productivity was evaluated of stalks and sugar, plots were used in five plant lines by eight meters were willing randomized block design with six replications, and collected at the end of the cycle, or, to 315 DAP. At each sampling time, the first experiment examined content of shikimic acid, quinic acid ...
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Pincelli-Souza, Renata Passos 1984. "Hormesis de glyphosate em cana-de-açúcar /." Botucatu, 2014. http://hdl.handle.net/11449/123371.
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Orientador: Marcelo de Almeida SilvaBanca: Carmen Silvia Fernandes Boaro
Banca: Edivaldo Domigues Velini
Banca: Elza Alves Correa
Banca: Eduardo Negrisoli
Resumo: Atualmente, tanto no setor de produção agrícola quanto nas diversas áreas da saúde humana, o efeito de subdoses de produtos aplicados, denominado como hormótico, vem sendo amplamente discutido e pesquisado, com o objetivo de compreender o mecanismo de ação estimulante e benéfica de diversas substâncias inicialmente consideradas como tóxicas, quando aplicadas em doses elevadas. O objetivo desta pesquisa foi verificar o efeito hormótico da subdose do herbicida glyphosate nas variáveis morfológicas, fisiológicas e a produção final de cana-de-açúcar. Os experimentos foram plantados em novembro de 2010 na Unidade de Pesquisa e Desenvolvimento de Jaú, SP, da APTA Pólo Centro-Oeste/SAA, conduzidos e avaliados durante o ciclo de cana-de-ano em cana-planta. A variedade utilizada foi a SP80-1842. Os tratamentos foram constituídos pela aplicação ou não de subdose de glyphosate. A aplicação dos tratamentos foi aos 70 dias após o plantio (DAP) e a subdose utilizada foi de 1,8 g e a ha-1 de glyphosate. No primeiro experimento foi avaliado o crescimento e desenvolvimento da cultura da cana-de-açúcar em parcelas de três linhas de plantio por três metros, nas quais foram coletadas um metro linear para avaliações em oito épocas, isto é, 70, 105, 140, 175, 210, 245, 280 e 315 dias após o plantio, em um delineamento de blocos casualizados com seis repetições. No segundo experimento, avaliou-se produtividade de colmos e de açúcar, foram utilizadas parcelas de cinco linhas de plantio por oito metros foram dispostas blocos casualizados com seis repetições, e coletadas ao final do ciclo da cultura, ou seja, aos 315 DAP. Em cada época de amostragem, do primeiro experimento, foram avaliados conteúdo de ácido chiquímico, ácido quínico, glyphosate e ácido aminometilfosfônico, teores de ...
Abstract: Currently, both in agricultural production and in areas of human health sector, the low dose effect of products applied, termed as hormetic, has been widely debated and researched in order to understand the mechanism of stimulating and beneficial action of several substances initially considered as toxic, when applied in high doses. The objective of this research was to investigate the effect of low dose of glyphosate on growth, phosphorus accumulation in the shoot, the production of shikimic and quinic acid, and final yield of sugarcane. The experiments were planted on November 05, 2010 in Research and Development Unit of Jaú, SP, APTA Polo Midwest / SAA, and carried out and evaluated over the course of the year in sugarcane plant cane. The variety used was SP80-1842. Two experiments were carried out to evaluate the effect hormetic during growth and development of sugarcane and cane yield and sugar. The treatments consisted at application or not of low dose of glyphosate. The spraying was at 70 DAP and the low dose dose used was 1.8 g a e ha-1 glyphosate. In the first experiment evaluated the growth and development of the sugar cane crop in portions of three planting rows of three meters, in which it was collected a linear meter for evaluations in eight times, or , 70, 105, 140, 175, 210, 245, 280 and 315 days after planting, in a randomized block design with six replications. In the second experiment, productivity was evaluated of stalks and sugar, plots were used in five plant lines by eight meters were willing randomized block design with six replications, and collected at the end of the cycle, or, to 315 DAP. At each sampling time, the first experiment examined content of shikimic acid, quinic acid ...
Doutor
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Deng, Chunqin. "Statistical Approach to Detect and Estimate Hormesis." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1004369636.
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Moraes, Carolina Pucci de [UNESP]. "Controle e hormesis de glyphosate em Brachiaria decumbens." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/143503.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O efeito de estímulo de uma característica biológica por baixas doses de um composto considerado tóxico, mas que em altas doses tem efeito inibitório é denominado efeito hormesis. Estímulos de crescimento em plantas têm sido verificados após a aplicação de subdoses de alguns herbicidas, incluindo o glyphosate. Nesse contexto, o presente trabalho teve por objetivo avaliar as respostas de crescimento de plantas de Brachiaria decumbens submetidas a diferentes doses de glyphosate. Foram realizados dois estudos em casa de vegetação, ambos em delineamento inteiramente casualizado (DIC). No primeiro estudo foram realizados três experimentos com seis repetições, sendo no experimento 1 testada uma curva de dose-resposta com nove doses do herbicida glyphosate (0; 22,5; 45; 90; 180; 360; 720; 1440 e 2880 g e.a. ha-1). Nos experimentos dois e três foram aplicadas onze doses do herbicida glyphosate (0; 2,8125; 5,625; 11,25; 22,5; 45; 90; 180; 360; 720 e 1440 g e.a. ha-1). No estudo 2 para a avaliação de subdoses com efeito hormesis realizou-se quatro experimentos, em DIC com oito repetições e dois tratamentos (testemunha e dose de 11,25 g e.a. ha-1). Para ambos os estudos foram coletadas oito plantas de vasos sem aplicação para a determinação da biomassa inicial dos experimentos. Nos experimentos do estudo 1 foram realizadas avaliações de fitointoxicação aos 0, 7, 14 e 21 dias após a aplicação (DAA), além da coleta de oito plantas por vaso de cada tratamento para determinação de massa fresca e massa seca. Além disso, realizou-se a quantificação de massa fresca e seca total dos vasos aos 21 DAA, sendo essa metodologia também adotada para os experimentos do estudo 2. Os resultados do estudo 1 indicaram que: em doses acima de 45 g e.a. ha-1 foi possível obter 80% de controle das plantas de B. decumbens; a aplicação de baixas doses de glyphosate estimulou o aumento da biomassa das plantas de B. decumbens, com valores máximos alcançados na subdose de 11,25 g e.a. ha-1 de glyphosate. O segundo estudo indicou que a aplicação de subdose de 11,25 g e.a. ha-1 de glyphosate promoveu tanto estímulo quanto inibição de crescimento, demonstrando haver variabilidade de resposta das plantas à essa subdose.
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Moraes, Carolina Pucci de 1989. "Controle e hormesis de glyphosate em Brachiaria decumbens /." Botucatu, 2016. http://hdl.handle.net/11449/143503.
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Orientador: Edivaldo Domingues VeliniBanca: Caio Atonio Carbonari
Banca: Luciano Soares de Souza
Resumo: O efeito de estímulo de uma característica biológica por baixas dosesde um composto considerado tóxico, mas que em altas doses tem efeito inibitório édenominado efeito hormesis. Estímulos de crescimento em plantas têm sido verificados apósa aplicação de subdoses de alguns herbicidas, incluindo o glyphosate. Nesse contexto, opresente trabalho teve por objetivo avaliar as respostas de crescimento de plantas deBrachiaria decumbens submetidas a diferentes doses de glyphosate. Foram realizados doisestudos em casa de vegetação, ambos em delineamento inteiramente casualizado (DIC). Noprimeiro estudo foram realizados três experimentos com seis repetições, sendo noexperimento 1 testada uma curva de dose-resposta com nove doses do herbicida glyphosate(0; 22,5; 45; 90; 180; 360; 720; 1440 e 2880 g e.a. ha-1). Nos experimentos dois e três foramaplicadas onze doses do herbicida glyphosate (0; 2,8125; 5,625; 11,25; 22,5; 45; 90; 180;360; 720 e 1440 g e.a. ha-1). No estudo 2 para a avaliação de subdoses com efeito hormesisrealizou-se quatro experimentos, em DIC com oito repetições e dois tratamentos (testemunhae dose de 11,25 g e.a. ha-1). Para ambos os estudos foram coletadas oito plantas de vasos semaplicação para a determinação da biomassa inicial dos experimentos. Nos experimentos doestudo 1 foram realizadas avaliações de fitointoxicação aos 0, 7, 14 e 21 dias após a aplicação(DAA), além da coleta de oito plantas por vaso de cada tratamento para determina... (Resumo completo, clicar acesso eletrônico abaixo)
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Nascentes, Renan Fonseca [UNESP]. "Hormesis de glyphosate em cana-de-açúcar e eucalipto." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/143505.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
O efeito de substâncias que em altas doses causa efeitos tóxicos, mas que em subdoses pode estimular a planta é conhecido como hormesis, sendo o glyphosate um herbicida com este efeito. Subdoses de glyphosate podem estimular o crescimento de uma diversidade de espécies de plantas, e tal resultado provavelmente esteja relacionado com o sítio de ação do glyphosate, uma vez que o efeito não é observado em plantas resistentes ao glyphosate. Diante disso, o presente trabalho teve como objetivo avaliar o efeito de hormesis do herbicida glyphosate em cana-de-açúcar e eucalipto. Para isso, foi conduzido quatros experimentos onde foram utilizados dez doses do herbicida glyphosate 0; 1,8; 3,6; 7,2; 18; 36; 72; 180; 360 e 720 g e.a.ha-1, aplicados com o auxilio de pulverizador estacionário com o volume de calda de 200 L ha-1. Nos experimentos foram avaliados a massa seca de parte aérea, fibra em detergente ácido (FDA), lignina, glyphosate, ácido chiquímico, conteúdo de clorofila, trocas gasosas (taxa de assimilação de CO2, condutância estomática e taxa de transpiração). Os resultados indicaram que a massa seca da parte aérea de cana-de-açúcar e eucalipto, apresentou incremento em doses variando de 3,6 a 18 g e.a ha-1. A aplicação de glyphosate proporcionou, em ambas as culturas, um incremento na taxa de assimilação de CO2, condutância estomática, taxa de transpiração, conteúdo de clorofila, sendo a dose variável para cada parâmetro analisado. Os níveis de FDA e lignina aumentaram em cana-de-açúcar após a aplicação de glyphosate, em todas as doses analisadas. Em resultados para eucalipto os níveis de FDA e lignina mantiveram-se estáveis, diminuindo em doses maiores. O herbicida glyphosate só foi detectado em cana-de-açúcar e eucalipto em doses a partir de 72 g e.a ha-1, da mesma forma os níveis de ácido chiquímico aumentaram.
The effect of substances that at high doses cause toxic effects, but in low doses can stimulate the plant is known hormesis. One herbicide which has been used for this purpose is glyphosate. Low doses of glyphosate can stimulate the growth of a variety of plant species, and such a result is probably related to glyphosate site of action, since the effect is not observed in glyphosate resistant plants. Therefore, this study aimed to evaluate the hormesis effect of glyphosate herbicide in sugarcane and eucalyptus. For this, it conducted four experiments where was used ten doses of glyphosate 0; 1.8; 3.6; 7.2; 18; 36; 72; 180; 360 and 720 g e.a. ha-1 , applied to the steady spray of aid with the spray volume of 200 L ha -1 . In the experiments were evaluated: dry mass of shoots, acid detergent fiber (ADF), lignin, glyphosate, shikimic acid, chlorophyll content, gas exchange (CO2 assimilation rate, stomatal conductance and transpiration rate). The results indicated that the dry mass of shoots of sugarcane and eucalyptus, increase in doses ranging from 3.6 to 18 g e.a. ha -1 . The application of glyphosate provided in both cultures, an increase in CO2 assimilation rate, stomatal conductance, transpiration rate, chlorophyll content, with variable dose for each parameter analyzed. FDA and lignin levels increased in sugarcane after application of glyphosate at all doses tested. In results to eucalyptus the FDA and lignin levels remained stable, decreasing at higher doses. The herbicide glyphosate was only detected in sugarcane and eucalyptus in doses above 72 g ha-1 , as the shikimic acid levels increased at the same way.
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Nascentes, Renan Fonseca 1990. "Hormesis de glyphosate em cana-de-açúcar e eucalipto /." Botucatu, 2016. http://hdl.handle.net/11449/143505.
Full textAbstract:
Orientador: Caio Antonio CarbonariBanca: Edivaldo Domingues Velini
Banca: Fernando Tadeu de Carvalho
Resumo: O efeito de substâncias que em altas doses causa efeitos tóxicos, mas que em subdoses pode estimular a planta é conhecido como hormesis, sendo o glyphosate um herbicida com este efeito. Subdoses de glyphosate podem estimular o crescimento de uma diversidade de espécies de plantas, e tal resultado provavelmente esteja relacionado com o sítio de ação do glyphosate, uma vez que o efeito não é observado em plantas resistentes ao glyphosate. Diante disso, o presente trabalho teve como objetivo avaliar o efeito de hormesis do herbicida glyphosate em cana-de-açúcar e eucalipto. Para isso, foi conduzido quatros experimentos onde foram utilizados dez doses do herbicida glyphosate 0; 1,8; 3,6; 7,2; 18; 36; 72; 180; 360 e 720 g e.a.ha-1, aplicados com o auxilio de pulverizador estacionário com o volume de calda de 200 L ha-1. Nos experimentos foram avaliados a massa seca de parte aérea, fibra em detergente ácido (FDA), lignina, glyphosate, ácido chiquímico, conteúdo de clorofila, trocas gasosas (taxa de assimilação de CO2, condutância estomática e taxa de transpiração). Os resultados indicaram que a massa seca da parte aérea de cana-de-açúcar e eucalipto, apresentou incremento em doses variando de 3,6 a 18 g e.a ha-1. A aplicação de glyphosate proporcionou, em ambas as culturas, um incremento na taxa de assimilação de CO2, condutância estomática, taxa de transpiração, conteúdo de clorofila, sendo a dose variável para cada parâmetro analisado. Os níveis de FDA e lignina aumentaram em cana-de-açúcar após a aplicação de glyphosate, em todas as doses analisadas. Em resultados para eucalipto os níveis de FDA e lignina mantiveram-se estáveis, diminuindo em doses maiores. O herbicida glyphosate só foi detectado em cana-de-açúcar e eucalipto em doses a partir... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The effect of substances that at high doses cause toxic effects, but in low doses can stimulate the plant is known hormesis. One herbicide which has been used for this purpose is glyphosate. Low doses of glyphosate can stimulate the growth of a variety of plant species, and such a result is probably related to glyphosate site of action, since the effect is not observed in glyphosate resistant plants. Therefore, this study aimed to evaluate the hormesis effect of glyphosate herbicide in sugarcane and eucalyptus. For this, it conducted four experiments where was used ten doses of glyphosate 0; 1.8; 3.6; 7.2; 18; 36; 72; 180; 360 and 720 g e.a. ha-1, applied to the steady spray of aid with the spray volume of 200 L ha -1 . In the experiments were evaluated: dry mass of shoots, acid detergent fiber (ADF), lignin, glyphosate, shikimic acid, chlorophyll content, gas exchange (CO2 assimilation rate, stomatal conductance and transpiration rate). The results indicated that the dry mass of shoots of sugarcane and eucalyptus, increase in doses ranging from 3.6 to 18 g e.a. ha -1 . The application of glyphosate provided in both cultures, an increase in CO2 assimilation rate, stomatal conductance, transpiration rate, chlorophyll content, with variable dose for each parameter analyzed. FDA and lignin levels increased in sugarcane after application of glyphosate at all doses tested. In results to eucalyptus the FDA and lignin levels remained stable, decreasing at higher doses. The herbicid... (Complete abstract click electronic access below)
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Duarte, Sierra Arturo. "Abiotic stress hormesis : hormetic stresses to maintain quality and enhance glucosinolates and phenolic compounds in broccoli (Brassica oleracea var. italica) during storage." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26529.
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Le brocoli (Brassica oleracea var. italica) est un légume devenu populaire grâce à ses caractéristiques nutritionnelles et bioctives qui sont associées entre autres à la prévention de certaines maladies chroniques. L'utilisation de stress abiotiques tels que UV-C comme traitement de pré-entreposage a montré un grand potentiel pour l'induction de la résistance aux maladies et la préservation de la qualité des produits frais, et il est de plus en plus évident qu'il existe un potentiel pour améliorer les métabolites secondaires. L'objectif de ce travail a été, d'abord, d'établir si divers stress abiotiques, UV-B, UV-C, la chaleur, l'ozone, le peroxyde d'hydrogène, l'éthanol, et méthyl jasmonate (MeJA), induisent le phénomène d’hormèse. L'effect de ces traitements sur certains paramètres associés à la qualité des fleurons de brocoli tels que: la couleur, la perte de poids, la teneur en glucosinolates et en composés phénoliques. La chaleur et l'éthanol ont été les meilleurs traitements pour le retarder le jaunissement des fleurons, mais UV-C et UV-B étaient également efficaces pour maintenir la couleur verte de fleurons dans l’entreposage. D'autre part, la capacité antioxydant des fleurons a été principalement renforcée par les traitements d’UV-B et de chaleur. Le paramètre le plus important dans cette recherche était la teneur en glucosinolates de fleurons qui a été influencé positivement par le traitement à l’ozone et au peroxyde d'hydrogène, et dans une moindre mesure par le traitement d’UV-B. Il a été conclu que les stress abiotiques peuvent influencer favorablement soit la qualité ou l’augmentation de glucosinolates dans les fleurons pendant l’entreposage, mais pas le deux. Parmi les agents stressants utilisés, la lumière UV-B a été le plus efficace à maintenir la qualité et à induire une augmentation des composantes phytochimiques dans le broccoli.Broccoli (Brassica oleracea var. Italica) has become popular thanks to its health properties that are associated with the prevention of certain chronic diseases. The use of abiotic stresses such as UV-C as pre-storage treatment has shown great potential for induction of disease resistance in and preservation of quality of fresh produce, and it is becoming increasingly clear that there is potential for enhancing secondary metabolites. The objective of this work was, first, to establish whether various abiotic stresses, UV-B UV-C, heat, ozone, hydrogen peroxide, ethanol, and the plant signalling molecule, methyl jasmonate (MeJA), may induce hormesis in broccoli florets on color retention response; and second, to determine the effect of various abiotic stresses on quality, mainly color retention and weight loss; the contents of glucosinolates and phenolic compounds in florets during storage. Heat and ethanol were the best treatments for delaying yellowing florets, but UV-C and UV-B were also effective at a lower extent. On the other hand, the antioxidant capacity of the florets was mostly enhanced by UV-B and heat treatments. The most important enquiry in this research was the augmentation of glucosinolates titers, which was influenced by the treatment with ozone and hydrogen peroxide, and to a less extent by UV-B. It was concluded that abiotic stresses could influence favourably either the quality or the enhancement of glucosinolates in broccoli during storage and not both. Among the considered stressing factors, UV-B was the most effective for maintenance of quality as well as to elevate the levels of phytochemicals in broccoli.
Books on the topic "Hormesis"
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Mattson, Mark P., and Edward J. Calabrese, eds. Hormesis. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-495-1.
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Radiation hormesis. Boca Raton, Fla: CRC Press, 1991.
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Sanders, Charles L. Radiobiology and Radiation Hormesis. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56372-5.
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L, Sanders Charles. Radiation hormesis and the linear-no-threshold assumption. Heidelberg: Springer, 2010.
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Sanders, Charles L., ed. Radiation Hormesis and the Linear-No-Threshold Assumption. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-03720-7.
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Hormesis: A revolution in biology, toxicology, and medicine. New York: Springer, 2010.
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Jahrestagung, Vereinigung Deutscher Strahlenschutzärzte. Strahlenreaktionen der Lunge: Hormesis : Richtlinie Strahlenschutz in der Medizin. Stuttgart: G. Fischer, 1994.
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Costantini, David. Oxidative Stress and Hormesis in Evolutionary Ecology and Physiology. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54663-1.
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Madeleine, Bastide, and International Research Group on Very Low Dose and High Dilution Effects., eds. Signals and images: Selected papers from the 7th and 8th GIRI meeting, held in Montpellier, France, November 20-21, 1993, and Jerusalem, Israel, December 10-11, 1994. Dordrecht [Netherlands]: Kluwer Academic Publishers, 1997.
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Mild stress and healthy aging: Applying hormesis in aging research and interventions. [Dordrecht]: Springer, 2008.
Find full textBook chapters on the topic "Hormesis"
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Sainburg, Robert L., Andrew L. Clark, George E. Billman, Zachary J. Schlader, Toby Mündel, Kevin Milne, Earl G. Noble, et al. "Hormesis." In Encyclopedia of Exercise Medicine in Health and Disease, 414. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2496.
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Aldwin, Carolyn M., and Michael R. Levenson. "Hormesis." In Encyclopedia of Sciences and Religions, 1021. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-1-4020-8265-8_200063.
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Mattson, Mark P., and Edward J. Calabrese. "Hormesis: What it is and Why it Matters." In Hormesis, 1–13. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-495-1_1.
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Calabrese, Edward J., and Mark P. Mattson. "The Hormetic Pharmacy: The Future of Natural Products and Man-Made Drugs in Disease Prevention and Treatment." In Hormesis, 177–98. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-495-1_10.
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Calabrese, Edward J. "Hormesis: Once Marginalized, Evidence Now Supports Hormesis as the Most Fundamental Dose Response." In Hormesis, 15–56. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-495-1_2.
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Mattson, Mark P. "The Fundamental Role of Hormesis in Evolution." In Hormesis, 57–68. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-495-1_3.
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Son, Tae Gen, Roy G. Cutler, Mark P. Mattson, and Simonetta Camandola. "Transcriptional Mediators of Cellular Hormesis." In Hormesis, 69–93. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-495-1_4.
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Chadwick, Wayne, and Stuart Maudsley. "The Devil is in the Dose: Complexity of Receptor Systems and Responses." In Hormesis, 95–108. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-495-1_5.
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Stranahan, Alexis M., and Mark P. Mattson. "Exercise-Induced Hormesis." In Hormesis, 109–22. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-495-1_6.
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Martin, Bronwen, Sunggoan Ji, Caitlin M. White, Stuart Maudsley, and Mark P. Mattson. "Dietary Energy Intake, Hormesis, and Health." In Hormesis, 123–37. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-495-1_7.
Full textConference papers on the topic "Hormesis"
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OBERBAUM, MENACHEM. "HORMESIS." In Proceedings of the International School of Biophysics. WORLD SCIENTIFIC, 1998. http://dx.doi.org/10.1142/9789812816887_0002.
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Dascaliuc, Alexandru. "Hormesis, screening and practical use of biostimulators in agriculture." In International Scientific Symposium "Plant Protection – Achievements and Prospects". Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2020. http://dx.doi.org/10.53040/9789975347204.44.
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The term hormesis describes the biphasic response of any biological system to increasing the dose of the stress factor of a different nature, characterized in that low doses have stimulating, beneficial effects. In contrast, high doses cause harmful, inhibitory effects. The hormonal response is practically universal, being stimulated by the action of toxic substances, heavy metal ions, hormones, including physical factors. The standard type of response to different factors suggests installing these evolving mechanisms, so they are of particular interest in elucidating plant adaptation mechanisms to various stressors, including developing screening methods and practical use of biostimulators. The practical use of hormesis principles was the theoretical basis for elaboration and rational use of the biostimulator Reglalg in agriculture.
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Yu, K. N., and Y. K. Fung. "Effects of photon hormesis on cells irradiated by alpha particles." In 1st Electronic Conference on Molecular Science. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/ecms-1-d002.
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Chukova, Yu P. "RADIATION HORMESIS IN THE LIGHT OF THE LAWS OF QUANTUM THERMODYNAMICS." In RAD Conference. RAD Association, 2019. http://dx.doi.org/10.21175/radproc.2018.46.
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Cutler, Chris. "Can poisons stimulate bees? Appreciating the potential of hormesis in beepesticide research." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.108960.
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Pearce, Oliver M. T., Heinz Läubli, Andrea Verhagen, Patrick Secrest, Jiquan Zhang, Paul R. Crocker, Nissi Varki, Jack Bui, and Ajit Varki. "Abstract 1063: Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1063.
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Wakeford, Richard, and E. Janet Tawn. "The Risk to Health From Exposure to Low Doses of Ionising Radiation." In ASME 2003 9th International Conference on Radioactive Waste Management and Environmental Remediation. ASMEDC, 2003. http://dx.doi.org/10.1115/icem2003-4927.
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Controversy continues over the shape of the dose-response curve describing the risk of stochastic health effects (cancer and hereditary disorders) following exposure to low doses of ionising radiation. Radiological protection is currently based upon the assumption that the dose-response curve has no threshold and is linear in the low dose region. This position is challenged by groups suggesting either that this approach seriously underestimates the true risk at low doses or that low-level exposure results in no risk (a threshold dose exists) or even a beneficial effect (“radiation hormesis”). In this paper, we examine the epidemiological and radiobiological bases of the linear no-threshold model and some of the alternatives that have been proposed. We conclude that the evidence for a material deviation from a linear no-threshold dose-response relationship at low doses is not persuasive and that the standard model provides the most parsimonious description of the available scientific evidence.
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Giannoni, Luca, and Marino Mazzini. "Exposure to Low Doses of Ionizing Radiation: Is the Linear No-Threshold Model Valid?" In 2014 22nd International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icone22-30967.
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The risk assessment for population’s exposures to low doses and low dose-rates of ionizing radiation is still subject to clear uncertainties. The issue has outstanding societal importance in relation to radiologic occupational safety, medical applications of radiation, effects of the natural background radioactivity and the future of nuclear power, due to its particular influence on the public acceptance of this form of energy. This review article analyzes, in a critical, historical and bibliographical manner, the worldwide accepted hypothesis of linearity without a threshold dose (LNT model). As well known, it rejects, from its first proposal in 1946 by American geneticist and Nobel laureate Hermann J. Muller, the concept of zero-risk for exposures to any dose level of ionizing radiation. The starting point is the dose-effects relationship provided by this model and related risk’s excess graphic curve. The biological and physical motivations for the linearity assumption are argued and challenged by the explanation of human body’s natural defense mechanisms and its repair capacity of the radiation damage. Furthermore, the historical and political truthfulness of the LNT model is also contested by the review of a recent investigation by Prof. Edward Calabrese, regarding the lack of scientific sources behind Muller’s Nobel Prize Lecture. Calabrese’s inquiry demonstrates that Muller, at the moment of his declaration on LNT model’s validity, had experimental proofs contradicting his conclusions about the unacceptability of a threshold dose. This finding is of historical importance since Muller’s Nobel Lecture is a turning point in the acceptance of the linearity model in risk assessment by the major regulatory agencies till today. Finally, the results of many epidemiological and statistical studies are shown specifically. They give further evidences concerning the inapplicability of the LNT model and its overestimation of the risk for various cases of exposures to low doses of ionizing radiation in different fields. By that, hormesis model is also discussed, with its assumption of possible benefits for the organism following low dose exposures: a dose-response model characterized by low-dose stimulation and high-dose inhibition, which has been frequently observed in the aforementioned studies. The argumentations and the experimental evidences provided here challenge the validity of the LNT model. We contest the fact that its establishment is principally based on a cautionary philosophy on nuclear public safety, rather than on actual scientific comprehension of the phenomenon. As such, it implies an exaggerated conception of the radiological hazard. In particular, this article calls attention to the need for a deeper understanding of the biological impact of low doses of ionizing radiation and the development of further specific and exhaustive researches.
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Zhu, Jiang, Daoli Yang, Rongbing Fu, Wenhua Wang, Xiaopin Guo, and Hongwei Yao. "Hormetic Effects of Mercury on Survival of Eisenia fetida (Oligochaeta)." In International Conference On Civil Engineering And Urban Planning 2012. Reston, VA: American Society of Civil Engineers, 2012. http://dx.doi.org/10.1061/9780784412435.055.
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Okoli, Uzoamaka, Michael Okafor, Chioli Chijioke, and Iroka Udeinya. "Hormetic low dose effect of DFHCOP-A depletes ionic calcium and elevates serum pH to inhibit cancer in Nigerian triple-negative breast cancer PDX model." In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11529.
Full textReports on the topic "Hormesis"
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Kale, Purushottam. JP8 Induced Mutagenesis and Hormesis. Fort Belvoir, VA: Defense Technical Information Center, March 2008. http://dx.doi.org/10.21236/ada479392.
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Calabrese, Edward J. Chemical/Radiation Hormesis Database, Evaluation of Hormetic Mechanisms and their Biomedical and Risk Assessment Implications. Fort Belvoir, VA: Defense Technical Information Center, March 2008. http://dx.doi.org/10.21236/ada479360.
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