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Academic literature on the topic 'Homeostatis'

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Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "Homeostatis"

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Goumenjuk, E. "Hormonal treatment and lipid homeostatis in premenopausal women." Pathophysiology 5 (June 1998): 46. http://dx.doi.org/10.1016/s0928-4680(98)80454-9.

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Lazovic, Biljana, Mirjana Zlatkovic-Svenda, Tijana Durmic, Zoran Stajic, Vesna Djuric, and Vladimir Zugic. "The regulation role of carotid body peripheral chemoreceptors in physiological and pathophysiological conditions." Medical review 69, no. 11-12 (2016): 385–90. http://dx.doi.org/10.2298/mpns1612385l.

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Introduction. The major oxygen sensors in the human body are peripheral chemoreceptors, also known as interoreceptors-as connected with internal organs, located in the aortic arch and in the body of the common carotid artery. Chemoreceptor function under physiological conditions. Stimulation of peripheral chemoreceptors during enviromental hypoxia causes a reflex-mediated increased ventilation, followed by the increase of the muscle sympatic activity, aiming to maintain tissue oxygen homeostatis, as well as glucosae homeostatis. Besides that, peripheral chemoreceptors interact with central chemoreceptors, responsible for carbon dioxide changes, and they are able to modulate each other. Chemoreceptor function in pathophysiological conditions. Investigations of respiratory function in many pathological processes, such as hypertension, obstructive sleep apnea, congestive heart failure and many other diseases that are presented with enhanced peripheral chemosensitivity and impaired functional sympatholysis ultimately determine the peripheral chemoreceptor role and significance of peripheral chemoreceptors in the process of those pathological conditions development. Considering this, the presumed influence of peripheral chemoreceptors is important in patients having the above mentioned pathology. Conclusion. The importance and the role of peripheral chemoreceptors in the course of the breathing control is still controversial, despite many scientific attempts to solve this problem. The main objective of this review is to give the latest data on the peripheral chemoreceptor role and to highlight the importance of peripheral chemoreceptors for maintaining of oxygen homeostasis in pateints with hypoxia caused by either physiological or pathological conditions.
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Meilana, Anna, Nurrani Mustika Dewi, and Andi Wijaya. "Heterogeneous Stem Cells in Skin Homeostatis and Wound Repair." Indonesian Biomedical Journal 7, no. 2 (August 1, 2015): 87. http://dx.doi.org/10.18585/inabj.v7i2.74.

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BACKGROUND: The skin protects mammals from insults, infection and dehydration and enables thermoregulation and sensory perception. Various skin-resident cells carry out these diverse functions. Constant turnover of cells and healing upon injury necessitate multiple reservoirs of stem cells. The skin is a complex organ harboring several distinct populations of stem cells and a rich array of cell types. Advances in genetic and imaging tools have brought new findings about the lineage relationships between skin stem cells and their progeny. Such knowledge may offer novel avenues for therapeutics and regenerative medicine.CONTENT: In the past years, our view of the mechanisms that govern skin homeostasis and regeneration have markedly changed. New populations of stem cells have been identified that behave spatio-temporally differently in healthy tissues and in situations of damage, indicating that a great level of stem cell heterogeneity is present in the skin. There are believed to be distinct populations of stem cells in different locations. The lineages that they feed are normally constrained by signals from their local environment, but they can give rise to all epidermal lineages in response to appropriate stimuli. Given the richness of structures such as blood vessels, subcutaneous fat, innervation and the accumulation of fibroblasts under the upper parts of the rete ridges (in the case of human skin), it is reasonable to speculate that the microenvironment might be essential for interfollicular epidermal homeostasis. The bloodstream is probably the main source of long-range signals reaching the skin, and cues provided by the vascular niche might be essential for skin homeostasis.SUMMARY: A key function of the interfollicular epidermis is to act as a protective interface between the body and the external environment, and it contains several architectural elements that enable it to fulfill this function. All elements of the epidermis play active roles in regulating skin function, which might not have been anticipated from their role in maintaining skin integrity. Skin cell research benefits from the integration of complementary technologies and disciplines. How skin function is regulated and how it may be possible to intervene to treat a variety of skin conditions. Ultimately also impairing the maintenance of self-renewing satellite cells. Therefore, only anti-aging strategies taking both factors, the stem cell niche and the stem cells per se, into consideration may ultimately be successful.KEYWORDS: epidermis, hair follicle, fibroblast, skin stem cells, homeostasis, regeneration
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Nef, Holger, Petra Kindle, Antje Technau, Christoph Bode, Jutta Schaper, and Albrecht Elsässer. "Alterations of calcium homeostatis induce contractile dysfunction in hibernating myocardium." Journal of Molecular and Cellular Cardiology 33, no. 6 (June 2001): A83. http://dx.doi.org/10.1016/s0022-2828(01)90331-1.

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Wu, Jian Kang, Zhipei Huang, Zhiqiang Zhang, Wendong Xiao, and Hong Jiang. "Quantitative Assessment of Autonomic Regulation of the Cardiac System." Journal of Healthcare Engineering 2019 (April 21, 2019): 1–8. http://dx.doi.org/10.1155/2019/4501502.

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Autonomic neural system (ANS) regulates the circulation to provide optimal perfusion of every organ in accordance with its metabolic needs, and the quantitative assessment of autonomic regulation is crucial for personalized medicine in cardiovascular diseases. In this paper, we propose the Dystatis to quantitatively evaluate autonomic regulation of the human cardiac system, based on homeostatis and probabilistic graphic model, where homeostatis explains ANS regulation while the probability graphic model systematically defines the regulation process for quantitative assessment. The indices and measurement methods for three well-designed scenarios are also illustrated to evaluate the proposed Dystatis: (1) heart rate variability (HRV), blood pressure variability (BPV), and respiration synchronization (Synch) in resting situation; (2) chronotropic competence indices (CCI) in graded exercise testing; and (3) baroreflex sensitivity (BRS), sympathetic nerve activity (SNA), and parasympathetic nerve activity (PNA) in orthostatic testing. The previous clinical results have shown that the proposed method and indices for autonomic cardiac system regulation have great potential in prediction, diagnosis, and rehabilitation of cardiovascular diseases, hypertension, and diabetes.
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Belkacemi, Louiza, Ghalem Selselet-Attou, Emeline Hupkens, Evrard Nguidjoe, Karim Louchami, Abdullah Sener, and Willy J. Malaisse. "Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats." International Journal of Endocrinology 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/962012.

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This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. Theβ-cell mass, as well as individualβ-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptoticβ-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects.
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Nie, Guangjun, Alex D. Sheftel, Sangwon F. Kim, and Prem Ponka. "Overexpression of Mitochondrial Ferritin Causes Cytosolic Iron Starvation and Changes Cellular Iron Homeostatis." Blood 104, no. 11 (November 16, 2004): 3195. http://dx.doi.org/10.1182/blood.v104.11.3195.3195.

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Abstract Cytosolic ferritin is well known to sequester and store iron and, consequently, protect cells against iron-mediated free radical damage. However, the function of the newly discovered mitochondrial ferritin (MtFt) is unknown. To examine the role of MtFt in cellular iron metabolism, we established a cell line that stably overexpresses the mouse MtFt under the control of tetracycline. The overexpression of MtFt caused a dose-dependent iron deficiency in the cytosol that was revealed by increased RNA-biding activity of iron regulatory proteins (IRPs) with a concomitant increase in transferrin receptor levels and a decrease in cytosolic ferritin. Consequently, the induction of MtFt resulted in a dramatic increase (2-fold) in cellular iron uptake from transferrin, most of which ended up in MtFt within mitochondria. Similarly, the induction of MtFt caused a shift of iron from cytosolic ferritin to MtFt. Moreover, the cell permeable iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) mobilized approximately twice as much iron from wild-type cells as compared to those overexpressing MtFt suggesting that iron in this protein is less accessible to SIH. Furthermore, the expression of MtFt was associated with a decrease in the activity of both mitochondrial and cytosolic aconitase activity, the latter being in agreement with the increase of IRP binding activity. In conclusion, our results indicate that the overexpression of MtFt causes a dramatic change in intracellular iron homeostasis and that the shunt of iron to mitochondrial storage protein likely limits its availability for functional iron proteins.
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Mounaji, Khadija, Nour-Eddine Erraiss, and Maurice Wegnez. "Identification of Metallothionein in Pleurodeles waltl." Zeitschrift für Naturforschung C 57, no. 7-8 (August 1, 2002): 727–31. http://dx.doi.org/10.1515/znc-2002-7-830.

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The characterization of metallothionein in the Urodele amphibian species Pleurodeles waltl was achieved. A simple and rapid method for identification of metallothionein, based on its strong affinity for cadmium (109Cd), was used. We were able to show that metallothionein is constitutively synthesized in liver, ovary and brain. The property of metallothionein to strongly bind essential (Zn, Cu) as well as toxic (Cd, Hg) metals is consistent with a dual role in cellular metabolism, i.e. homeostatis and detoxification of heavy metal ions.
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Ozyazici, Sefa, Faruk Karateke, Umit Turan, Adnan Kuvvetli, Huseyin Kilavuz, Burak Karakaya, Pınar Ozaltun, Murat Alısık, and Ozcan Erel. "A Novel Oxidative Stress Mediator in Acute Appendicitis: Thiol/Disulphide Homeostasis." Mediators of Inflammation 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6761050.

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Aim. To investigate the role of a novel oxidative stress marker, thiol/disulphide homeostasis, in patients diagnosed with acute appendicitis (AA).Methods. In this study, seventy-one (43 male and 28 female) patients diagnosed with AA and 71 (30 male and 41 female) healthy volunteers were included. Age, gender, body mass index (BMI), haemoglobin (Hb), white blood cell (WBC), c-reactive protein (CRP), and thiol/disulphide homeostasis parameters (native thiol, total thiol, disulphide, disulphide/native thiol, native thiol/total thiol, and disulphide/total thiol ratios) were compared between the groups. Thiol/disulphide homeostasis was determined by a newly developed method by Erel and Neselioglu.Results. The native thiol, total thiol, and the native thiol/total thiol ratio levels were statistically significantly decreased in the AA compared with the control group (p<0.001). Disulphide level and the ratios of disulphide/native thiol and disulphide/total thiol were higher in the AA group than in the control group (p<0.001). There was a negative correlation of CRP with native thiol, total thiol, and native thiol/total thiol ratio while there was a positive correlation of CRP with disulphide/native thiol and disulphide/total thiol in the AA group. In the stepwise regression model, risk factors as disulphide/native thiol (OR = 1.368;p=0.018) and CRP (OR = 1.635;p=0.003) were determined as predictors of perforated appendicitis compared to the nonperforated group.Conclusion. This is the first study examining the thiol/disulphide homeostasis as a diagnostic aid in AA and establishing thiol/disulphide homeostatis balance shifted towards the disulphide formation due to thiol oxidation. Further studies are needed to optimize the use of this novel oxidative stress marker in AA.
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Oldner, Anders, Michel Goiny, Urban Ungerstedt, and Alf Sollevi. "SPLANCHNIC HOMEOSTATIS DURING ENDOTOXIN CHALLENGE IN THE PIG AS ASSESSED BY MICRODIALYSIS AND TONOMETRY." Shock 6, no. 3 (September 1996): 188–93. http://dx.doi.org/10.1097/00024382-199609000-00006.

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Dissertations / Theses on the topic "Homeostatis"

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Cooke, Jennifer. "The hypothalamic Regulation of Energy Homeostatis." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503772.

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Dixon, Peter Hendy. "Molecular genetic studies of hypophosphataemic and hypoparathyroid disorders." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322579.

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Miller, C. "A study of the influences on mineral homeostatis in infants fed synthetic milk formulae." Thesis, Robert Gordon University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377550.

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Alessa, Lilian. "The effects of aluminum on cytoplasmic organization, the F-actin array and calcium homeostatis in Vaucharia longicaulis var.macounii." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0035/NQ27102.pdf.

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Dahdah, Albert. "Mast cell deficiency and calcium homeostatis : their imprints on cells of the immune systeme and implications in Sepsis." Paris 7, 2013. http://www.theses.fr/2013PA077213.

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Les cellules du sytème immunitaire ont un rôle important pour notre défense et l'élimination des agents pathogènes qui nous envahissent. De ce fait, il est nécessaire que les deux types de réponses (pro- et anti-inflammatoire) de ce système soient régulées, une réponse pro-inflammatoire insuffisante, ou trop forte, pourrait conduire à des lésions dans les tissus sièges de l'inflammation, et une réponse anti-inflammatoire excessive pourrait inhiber la réponse immune ouvrant la voie à une dissémination de bactéries, virus, et parasites. Heureusement, notre système immunitaire est bien équipé pour faire face à ces situations. Dans le cas du Sepsis, la réaction inflammatoire exagérée qui s'ensuit devient écrasante à l'hôte et conduit à une dérégulation du système, conduisant à une translocation des bactéries dans les organes, entraînant des lésions irréversibles, une perturbation de leur fonctionnement, et pouvant aller jusqu'à la mort. La dérégulation de ce système causé par le Calcium (Ca2+) en premier lieu et les Mastocytes étaient le centre de nos études. Dans une première étude chez la souris Trpm4-I-, nous montrons qu'un défaut de régulation de la réponse calcique chez le macrophage, est essentiel pour la survie des souris dans un modèle de Sepsis induit par CLP (Caecal Ligation and Puncture). Les macrophages déficitaires pour le canal TRPM4 (régulateur du Ca2+) présentent une surcharge calcique modifiant leurs fonctions de phogocytose. Ce qui se traduit par une augmentation du titre bactérien et une diminution de survie des souris. Dans une deuxième étude, nous proposons un nouveau modèle de souris déficientes en mastocyte, qui nous permet de décrypter le rôle de cette cellule dans les premières phases du Sepsis sévère, et son rôle anti-inflammatoire sur la phagocytose du macrophage. Un rôle qui se révèle délétère ; une ablation de ces cellules entraîne une meilleure survie, et un meilleur rétablissement des animaux. L'ensemble de nos études nous permet de préciser le rôle du Ca2+, ainsi que celui du Mastocyte dans le Sepsis, mais aussi d'établir de nouveaux mécanismes de régulation du système immunitaire dans les premiers stades du développement du Sepsis
Immune cells are important in host defense against invading pathogens, however, a balance is necessary between the beneficial and detrimental effects of this system. A strong pro-inflammatory response will help eliminate intrusions, but will also cause damage to neighboring tissues. On the orther hand, the role of an anti-inflammatory response, is to prevent such unnecessary scaring of organs, nevertheless, fairness of this immunoregulatory response is essential, because, otherwise, the inciting agents wont be eliminated, allowing microbial, viral, fungal, and parasitic infections to spread throughout the hosts system. Luckily, our immune system is well equipped to handle these situations, but in some cases, such as Sepsis, the exaggerated inflammatory reaction that ensues becomes overwhelming to the host and may result in organ damage ad mulfunction, leading to systemic shut down of the physiological system, and may cause death. The systemic deregulation of the immune system in Sepsis, and the shaping of the immune system by calcium or Mast cells in this disease was the focus of our studies. In a first study, we demonstrated, that calcium (Ca2+) homeostasis in Macrophages, and in Monocytes was essential for mice survival in a sepsis model induced by Ceacal Ligation and Puncture (CLP). In this model we showed, that an overflow of calcium could drastically impair survivability in mice defective in trpm4 channel, a channel responsible for limiting Ca2+ entry into Immune cells. The development of a new mice Mast Cell model in our laboratory, introduced a new tool for studying Mast Cells deficient models ; it allowed us to decrypt the role of mast cells in the development of sepsis. It appears, that in a model of severe peritonitis, Mast Cell presence is detrimental, because, its presence allowed a strong anti-inflammatory response, impairing phagocytes from achieving their role, and hence resulted in higher mortality rates when compared to mice lacking Mast Cells. The cumulated results generated by our team, allowed positioning the role of Ca2+, and Mast Cells in the pathogenesis of Sepsis. And provided new insights to regulation of immunity and the control of inflammation in early stages of Sepsis
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Valdez, Glenn R. "Restoration of homeostasis within the stress system : a novel therapeutic approach for alcohol dependence /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3112199.

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Kisko, Mushtak. "Study of Physiological and molecular mechanisms underlying the co-regulation between phosphate and zinc homeostasis in plants." Thesis, Montpellier, SupAgro, 2018. http://www.theses.fr/2018NSAM0004/document.

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Chez les plantes, alors qu'il est clair que l'homéostasie des différents nutriments est fortement dépendante les uns des autres, ils sont généralement étudiés indépendamment les uns des autres. Étant donné la rareté des études antérieures évaluant la signification biologique de l'interaction de l'homéostasie des nutriments minéraux, on en sait très peu sur la base génétique et moléculaire de ces interactions. Au cours de ma thèse, nous avons progressé de manière significative vers une compréhension plus intégrative du problème et identifié les bases moléculaires et génétiques d'une interaction nutritive très importante et conservée: l'interaction du zinc et du phosphate, dans laquelle les gènes PHO1;H3 et Lyso PhosphatidylCholine (PC) AcylTransferase 1 (LPCAT1) jouent des rôles centraux. En combinant des approches de biologie systémique et de biologie fonctionnelle, nous avons identifié le module fonctionnel (quatre facteurs transcriptions) qui régule l'expression de PHO1; H3 en condition de carence en Zn. Suite à une étude de génétique d’association (GWAS) nous avons découvert un nouveau rôle du gène LPCAT1 dans l’accumulation du phosphate en conditions de carence en Zn, Ensuite, nous avons déterminé une voie moléculaire complète contrôlant l'expression de ce gène. Ce travail nous permis de révéler un lien fondamental entre le métabolisme des phospholipides et l'interaction homéostasie Pi-Zn, et de proposer un nouveau rôle pour Lyso-PC et PC dans le contrôle de l'interaction homéostasie macro- et micronutriments chez les plantes. Les résultats obtenus offrent une nouvelle perspective pour élabore des nouvelles stratégies pour améliorer l’accumulation de Pi dans les plantes via la modulation de la voie de signalisation de la carence en Zn
In plants, while it is clear the homeostasis of different nutrients is highly dependent on each other, they are usually studied independent of each other. Given the paucity of past studies assessing the biological significance of mineral nutrient homeostasis interaction, very little is known about the genetic and molecular basis of such interactions. During my thesis, we made significant progress in going towards a more integrative comprehension of the problem and identify the molecular and genetic bases for a highly important and conserved nutrients interaction: the interaction of zinc and phosphate. First, using the phosphate transporter PHO1;H3 as entry molecular point, and by combining system biology and functional genomics approaches we have identified the functional module (four transcription factors) that regulates the expression and activity of PHO1;H3 under Zn deficiency leading to control Pi accumulation in shoots. Second, following our discovery of Lyso PhosphatidylCholine (PC) AcylTransferase 1 (LPCAT1) using genome-wide association studies (GWAS), we determined complete molecular pathway controlling the expression of this gene. We further uncovered a fundamental link between phospholipid metabolism and Pi-Zn homeostasis interaction via LPCAT1, which lays the foundations to explore a new role for Lyso-PC and PC in control of macro- and micronutrients homeostasis interaction. Taken together, our discoveries offer a new perspective on how to improve Pi content in plants, as our findings suggests that modulating the Zn-deficiency signalling pathway might be a good and simple approach for that
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Sweeney, Yann Aodh. "Functional relevance of homeostatic intrinsic plasticity in neurons and networks." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20982.

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Maintaining the intrinsic excitability of neurons is crucial for stable brain activity. This can be achieved by the homeostatic regulation of membrane ion channel conductances, although it is not well understood how these processes influence broader aspects of neuron and network function. One of the many mechanisms which contribute towards this task is the modulation of potassium channel conductances by activity-dependent nitric oxide signalling. Here, we first investigate this mechanism in a conductance-based neuron model. By fitting the model to experimental data we find that nitric oxide signalling improves synaptic transmission fidelity at high firing rates, but that there is an increase in the metabolic cost of action potentials associated with this improvement. Although the improvement in function had been observed previously in experiment, the metabolic constraint was unknown. This additional constraint provides a plausible explanation for the selective activation of nitric oxide signalling only at high firing rates. In addition to mediating homeostatic control of intrinsic excitability, nitric oxide can diffuse freely across cell membranes, providing a unique mechanism for neurons to communicate within a network, independent of synaptic connectivity. We next conduct a theoretical investigation of the distinguishing roles of diffusive homeostasis mediated by nitric oxide in comparison with canonical non-diffusive homeostasis in cortical networks. We find that both forms of homeostasis robustly maintain stable activity. However, the resulting networks differ, with diffusive homeostasis maintaining substantial heterogeneity in activity levels of individual neurons, a feature disrupted in networks with non-diffusive homeostasis. This results in networks capable of representing input heterogeneity, and linearly responding over a broader range of inputs than those undergoing non-diffusive homeostasis. We further show that diffusive homeostasis interferes less than non-diffusive homeostasis in the synaptic weight dynamics of networks undergoing Hebbian plasticity. Overall, these results suggest a novel homeostatic mechanism for maintaining stable network activity while simultaneously minimising metabolic cost and conserving network functionality.
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Taylor, Michael Jay. "The Role of Homeostatic Imbalance in the Reported Immunomodulation of T-2 Toxin." DigitalCommons@USU, 1988. https://digitalcommons.usu.edu/etd/3836.

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T-2 toxin (T-2), produced by the genus Fusarium, is a cytotoxic trichothecene mycotoxin, a feed contaminant, and has been shown to be immunomodulatory. It is suspected that T-2-associated immunomodulation is mediated partly through the hypothalamic-pituitary-adrenal axis. The presence of endotoxin, a bacterial product capable of activating the hypothalamic-pituitary-adrenal axis as well as the levels of several hormones, also associated with activation of the hypothalamic-pituitary-adrenal axis, were determined in both vehicle- and toxin-treated animals. Endotoxemia was evident twenty-four hours after a single oral exposure to T-2. Blood levels of adrenocorticotropic hormone and corticosterone, parameters of the stress response, also increased twenty-four hours after T-2 exposure. Hypothalamic norepinephrine and serum corticosterone levels increased in a dose-related manner after two weeks of T-2 exposure. An increased corticosteroid level was associated with thymic involution leading potentially to decreased T-dependent antibody response, a known effect of T-2. The effects of exposure to T-2 on the development of both T-dependent and T-independent antibody response were determined in nonoperated, sham-operated and adrenalectomized mice. T-2 decreased the antibody response to a T-dependent antigen and increased a T-independent response. The effects of T-2 were partially nullified by adrenalectomy. These results provide a further confirmation of the postulate that the hypothalamic-pituitary-adrenal axis plays an important role in T-2 toxin-immunomodulation. In vitro studies were undertaken to investigate the direct effects of T-2 on various populations of lymphatic cells. Exposure to T-2 after twenty-four hours caused an increase in the uptake of 3H-thymidine by mouse splenic cells. Pokeweed mitogen stimulation also increased in this system; the response to lipopolysaccharide increased to a lesser extent. However, T-cell responses to phytohaemagglutinin and concanavalin A (Con A) decreased. Thymic cells were also sensitive to T-2. The possibility of pharmacological activity of T-2 with thymocytes was investigated. Both specific and nonspecific cell associations were observed. The association of T-2 with thymocytes was altered in the presence of dexamethasone, a synthetic corticosteroid. T-2 was shown to have both indirect as well as direct activities on the immune system. Endocrine dysfunction resulting from chronic stress and possible pharmacologic activity of T-2 provide the impetus for further investigations.
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Val, Casals Maria 1993. "Circadian regulation of macrophages in homeostasis and disease." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/669532.

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Els ritmes circadians són oscil·lacions diàries en paràmetres fisiològics necessaris per a què els organismes adaptin la seva activitat als cicles de llum i foscor. A nivell molecular, la maquinària circadiana consisteix en bucles oscil·latoris de traducció-transcripció dirigides per l’activitat de les proteïnes BMAL1 i CLOCK de manera autònoma a cada cèl·lula. La maquinària circadiana regula l’activitat de diversos tipus de cèl·lules immunitàries, inclosos els macròfags. Concretament, BMAL1 pot controlar la magnitud diària de les respostes inflamatòries dels macròfags. En el present treball, es caracteritza la regulació circadiana dels macròfags en contextos encara no explorats. Hem analitzat l’expressió i els patrons oscil·ladors dels components del rellotge en poblacions de macròfags i també hem valorat el paper potencial dels rellotges en les funcions dels macròfags. Presentem resultats identificant aspectes de la funció del rellotge en macròfags que poden ajudar a comprendre la influència dels ritmes circadians en la modulació de respostes immunitàries innates.
Circadian rhythms are daily oscillations in physiological parameters required for organisms to adapt their activity to cycles of light and darkness. At the molecular level, the circadian machinery consists of cell-autonomous transcription-translation oscillation loops led by the activity of BMAL1 and CLOCK proteins. The circadian machinery regulates the activity of diverse immune cell types, including macrophages. Specifically, BMAL1 can control the daily magnitude of macrophage inflammatory responses. In the present work we characterize the circadian regulation of macrophages in yet unexplored contexts. We have analyzed the expression and oscillatory patterns of clock components in macrophage populations, and also assessed the potential role of clocks in macrophage functions. We present results identifying aspects of clock function in macrophages that can help understand the influence of circadian rhythms in the modulation of innate immune responses.
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Books on the topic "Homeostatis"

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Rheostasis: The physiology of change. Oxford: Oxford University Press, 1990.

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Protein homeostasis. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory Press, 2011.

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Smith, Robert Elijah. Mammalian homeostasis. Burlington, N.C: Carolina Biological Supply Co., 1987.

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Carafoli, Ernesto, and Joachim Krebs, eds. Calcium Homeostasis. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-58306-3.

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Gelissen, Ingrid C., and Andrew J. Brown, eds. Cholesterol Homeostasis. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6875-6.

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Snow, Andrew L., and Michael J. Lenardo, eds. Immune Homeostasis. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-290-2.

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Banfalvi, Gaspar. Homeostasis - Tumor - Metastasis. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-7335-6.

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The lower brainstem and bodily homeostasis. New York: Oxford University Press, 1997.

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N, Fawcett Josephine, ed. Pathophysiology, homeostasis and nursing. New York: Routledge, 2003.

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International Workshop on Phosphate and Other Minerals (7th 1985 Marseille, France). Phosphate and mineral homeostasis. New York: Plenum Press, 1986.

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Book chapters on the topic "Homeostatis"

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Caon, Martin. "Homeostasis." In Examination Questions and Answers in Basic Anatomy and Physiology, 139–49. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-75599-1_6.

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Soper, Roland. "Homeostasis." In Human Biology GCSE, 111–31. London: Macmillan Education UK, 1992. http://dx.doi.org/10.1007/978-1-349-12789-4_8.

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Tudor, Jacqueline Hill. "Homeostasis." In Encyclopedia of Animal Cognition and Behavior, 1–6. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-47829-6_1104-1.

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Balmores-Paulino, Rozel S. "Homeostasis." In Encyclopedia of Personality and Individual Differences, 1993–94. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-24612-3_674.

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Caon, Martin. "Homeostasis." In Examination Questions and Answers in Basic Anatomy and Physiology, 119–24. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-2332-3_6.

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Balmores-Paulino, Rozel S. "Homeostasis." In Encyclopedia of Personality and Individual Differences, 1–2. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-28099-8_674-1.

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Kilgour, O. F. G. "Homeostasis." In Work Out Biology for First Examinations, 153–65. London: Macmillan Education UK, 1986. http://dx.doi.org/10.1007/978-1-349-18139-1_9.

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Moreno, Alvaro, and Kepa Ruiz-Mirazo. "Homeostasis." In Encyclopedia of Astrobiology, 1113–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_730.

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Kilgour, O. F. G. "Homeostasis." In Work Out Biology GCSE, 159–71. London: Macmillan Education UK, 1987. http://dx.doi.org/10.1007/978-1-349-09450-9_9.

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Cummins, Robert A. "Homeostasis." In Encyclopedia of Quality of Life and Well-Being Research, 2901–4. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-0753-5_1303.

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Conference papers on the topic "Homeostatis"

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Zeinali-Davarani, Shahrokh, and Seungik Baek. "Testing Different Hypotheses of Vascular Homeostasis Based on Mechanical Stress or Strain in Image-Based Models Using an Inverse Method." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53213.

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Various hypotheses are previously suggested to describe the tendency of vascular tissue to adapt in response to alterations in mechanical stimuli. It is still a matter of controversy which mechanical quantity governs or correlates well with the adaptation, contributing to the mechanical homeostasis. A computational tool that can distinguish between different hypotheses under various physiological conditions may help better understanding of the governing rules. Recently, an inverse optimization method has been developed to estimate the optimal spatial distributions of arterial wall thickness and material anisotropy of image-based models while satisfying a homeostatic condition assumed [1]. The same numerical method can be utilized to investigate the consequent optimal structures resulting from different hypotheses for the mechanical homeostasis. We consider three hypotheses for a homeostatic state based on intramural stress or cyclic stretch and examine their effects on the optimized distributions of thickness and anisotropy. The results show the capability of the presented method in discriminating different hypotheses of vascular homeostasis with image-based models, the validity of which requires more experimental data.
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Hunley, S. C., S. Kwon, and S. Baek. "Influence of Surrounding Tissues on Biomechanics of Aortic Wall: A Feasibility Study of Mechanical Homeostasis." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19264.

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Previous research in cardiovascular mechanics has shown that mechanical factors strongly influence the growth and remodeling of blood vessels, thereby leading the hypothesis of mechanical homeostasis as a mechanism of regulating vascular adaptation [1]. Nevertheless, this assumption is mostly based on stress analysis of an idealized blood vessel. However, for the aorta, its motion is considerably limited by the surrounding tissue during the cardiac cycle, with the thickness of the posterior side significantly thinner than the anterior side (Fig. 1). In this work, we test the possibility of the existence of a homeostatic level of stress in the aorta using a linear plane-strain model that accounts for thickness variations and surrounding tissues. The results of this computational study show that the surrounding tissue, together with thickness variations, homogenizes the stress level of blood vessel under a physiological pressure, which implies that the mechanical homeostasis is still feasible even with thickness variations and the influence of the surrounding tissues in the aorta.
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Shrestha, Rajiv P., Yossi Chait, Christopher V. Hollot, Stuart Chipkin, and Claus P. Schmitt. "A Mathematical Model of Parathyroid Hormone Response to Acute Changes in Plasma Ionized Calcium Concentration in Humans." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67551.

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A complex bio-mechanism, referred to as calcium homeostasis, regulates plasma ionized calcium (Ca++) concentration in the human body to within a narrow physiologic range which is crucial for maintaining normal physiology and metabolism. In this paper we present a qualitative model of the calcium homeostatic system and then focus on a particular sub-system, termed Ca-PTH axis. We consider the dynamics of the axis involving the response of the parathyroid glands to acute changes in plasma Ca++ concentration. We use a two-pool, linear time-varying model to describe the Ca-PTH axis. We show that this model, parameterized using a guided iterative parametrization scheme and induced hypocalcemic clamp test data, successfully predicts dynamics observed in clinical tests of induced hypercalcemia in normal humans.
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Polyak, Emil. "Homeostasis." In SIGGRAPH '20: Special Interest Group on Computer Graphics and Interactive Techniques Conference. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3386567.3388559.

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Liu, Timon C., and Fan-Hui Li. "Photonic homeostatics." In Photonics Asia 2010, edited by Qingming Luo, Ying Gu, and Xingde Li. SPIE, 2010. http://dx.doi.org/10.1117/12.869918.

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Roy, Sudip, Lucja Kot, Gabriel Bender, Bailu Ding, Hossein Hojjat, Christoph Koch, Nate Foster, and Johannes Gehrke. "The Homeostasis Protocol." In SIGMOD/PODS'15: International Conference on Management of Data. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2723372.2723720.

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Nikolaevna, Dzyatkovskaya Elena. "Homeostatic Approach To Education." In 7th icCSBs 2018 - The Annual International Conference on Cognitive - Social, and Behavioural Sciences. Cognitive-Crcs, 2019. http://dx.doi.org/10.15405/epsbs.2019.02.02.40.

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Domin, C., and L. Medlin. "Homeostasis and perpetual change." In ECO-ARCHITECTURE 2010. Southampton, UK: WIT Press, 2010. http://dx.doi.org/10.2495/arc100031.

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Albegov, Yevgeny V., Dmitry V. Butenko, and Lyudmila N. Butenko. "Homeostatic approach to making biomodels." In the International Conference. New York, New York, USA: ACM Press, 2010. http://dx.doi.org/10.1145/1868013.1868015.

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Kiryu, Tohru. "Handling Risk Homeostasis in Biofunctions*." In 2020 IEEE 2nd Global Conference on Life Sciences and Technologies (LifeTech). IEEE, 2020. http://dx.doi.org/10.1109/lifetech48969.2020.1570618241.

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Reports on the topic "Homeostatis"

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Kilduff, Thomas S. Neurobiological Correlates of Sleep Homeostasis. Fort Belvoir, VA: Defense Technical Information Center, January 2001. http://dx.doi.org/10.21236/ada391757.

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Young, Jamey D., and Young M. Whang. Targeting Redox Homeostasis in LKB1-deficient NSCLC. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada614534.

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Booth, Victoria, Daniel Forger, and Cecilia Diniz Behn. Mathematical Modeling of Circadian and Homeostatic Interaction. Fort Belvoir, VA: Defense Technical Information Center, November 2011. http://dx.doi.org/10.21236/ada563698.

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R. Nebreda, Ángel. Señalización de estrés en la homeostasis tumoral: implicaciones terapéuticas. Sociedad Española de Bioquímica y Biología Molecular, October 2017. http://dx.doi.org/10.18567/sebbmdiv_anc.2017.10.1.

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Kongara, Sameera. Role of Autophagy in Keratin Homeostasis in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, December 2012. http://dx.doi.org/10.21236/ada583662.

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Kongara, Sameera. Role of Autophagy in Keratin Homeostasis in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, March 2014. http://dx.doi.org/10.21236/ada601249.

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Baccala, Roberto. Homeostatic T Cell Expansion to Induce Anti-Tumor Autoimmunity in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, April 2006. http://dx.doi.org/10.21236/ada456894.

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Juergens, Timothy M., Giulio Tononi, and Ruth Benca. Homeostatic and Circadian Abnormalities in Sleep and Arousal in Gulf War Syndrome. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada567969.

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Van Dongen, Hans P. Homeostatic and Circadian Modulation of Cognition: Integrating Mathematical and Computational Modeling Approaches. Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada579501.

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Juergens, Timothy M., Giulio Tononi, and Ruth Benca. Homeostatic and Circadian Abnormalities in Sleep and Arousal in Gulf War Syndrome. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada596544.

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