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Journal articles on the topic 'Homeostasis'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 September 2024

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1

Wang, Lin-Shu, and Peizheng Ma. "The homeostasis solution – Mechanical homeostasis in architecturally homeostatic buildings." Applied Energy 162 (January 2016): 183–96. http://dx.doi.org/10.1016/j.apenergy.2015.10.058.

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2

Kurniawan, Shahdevi Nandar. "INTRACELLULAR Ca2+ HOMEOSTASIS." MNJ (Malang Neurology Journal) 1, no. 1 (January 1, 2015): 36–45. http://dx.doi.org/10.21776/ub.mnj.2015.001.01.7.

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3

Rajkumar, R. Vinodh. "Perfect Homeostasis: pH." International Journal of Physiotherapy and Research 10, no. 1 (February 11, 2022): 4111–24. http://dx.doi.org/10.16965/ijpr.2021.213.

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Physiotherapists, Dieticians, and Exercise professionals have much better scope to become trailblazers in the forthcoming years to revamp the public health system and set spectacular trends in interdisciplinary health care for the people. Meanwhile, they must scrupulously engage in research pursuits and the dissemination of advanced knowledge in health and disease. A macrocosm of research literature in all the medical super-specializations are currently available but they would go futile if they are not unified and channelized for holistic and equitable health care. Human health is attained or maintained by acquiring homeostasis to coordinate and control a wide range of physiologic parameters within Narrow Homeostatic Range (NHR) that encompasses body temperature, pH, blood glucose level, blood cholesterol level, blood pressure, heart rate, respiratory rate, etc., Homeostasis tightly regulates NHR of all the physiologic parameters to develop homeostatic competence. Homeostatic competence is quite impossible without all the physiologic parameters harmoniously integrating with each other and working in their respective NHR. Physiologic parameters in NHR can be called as homeostatic factors. Deviation of even one physiologic parameter from its NHR could lead to temporary or permanent health disturbance due to disrupted homeostasis. But diseases tend to arise as a result of disturbance in all the physiologic parameters at the same time, though some or many of them could go unnoticed in the contemporary diagnostic procedures or due to lack of appropriate diagnosis. The homeostatic competence (or perfect homeostasis) of individuals that resists non-communicable diseases could also help resisting infectious diseases or vice versa. If only the data of physiologic parameters responsible for preventing non-communicable diseases are available, the health care professionals should be able to get a standpoint about the immunologic fitness of an individual (immunocompetent or immunocompromised) or if only the data of physiologic parameters responsible for immunologic fitness are available, the health care professionals should be able to get a standpoint about an individual’s ability to resist non-communicable diseases. These postulates on homeostatic competence can be made irrefutable by carefully reviewing the literature to establish associations between various homeostatic factors and the versatile roles played by each homeostatic factor in (i) preventing infectious diseases and non-communicable diseases (ii) maintaining pH and (iii) ensuring perfect homeostasis. Advancing Estimation and Gradation of Immunologic Status (AEGIS) can also be constructed putting together all homeostatic factors. Under the beneficial ecological conditions and lifestyle, human body as a biochemical machine would strive to adapt and converge all the versatile efforts of homeostatic factors to create perfect homeostasis for itself in association with a NHR for pH. Undoubtedly, at any age, Homeostatic Excellence Actuates Life Through Health (HEALTH) is naturally possible. KEY WORDS: Homeostasis, pH, Acid-base balance, Exercise, Nutrition, Ageing, Immunity, Infections, Non-communicable diseases, Public health

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4

Zakharov, V. M., and I. E. Trofimov. "Homeostatic mechanisms of biological systems: Development homeostasis." Russian Journal of Developmental Biology 45, no. 3 (May 2014): 105–16. http://dx.doi.org/10.1134/s1062360414030096.

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5

Meizlish, Matthew L., Ruth A. Franklin, Xu Zhou, and Ruslan Medzhitov. "Tissue Homeostasis and Inflammation." Annual Review of Immunology 39, no. 1 (April 26, 2021): 557–81. http://dx.doi.org/10.1146/annurev-immunol-061020-053734.

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There is a growing interest in understanding tissue organization, homeostasis, and inflammation. However, despite an abundance of data, the organizing principles of tissue biology remain poorly defined. Here, we present a perspective on tissue organization based on the relationships between cell types and the functions that they perform. We provide a formal definition of tissue homeostasis as a collection of circuits that regulate specific variables within the tissue environment, and we describe how the functional organization of tissues allows for the maintenance of both tissue and systemic homeostasis. This leads to a natural definition of inflammation as a response to deviations from homeostasis that cannot be reversed by homeostatic mechanisms alone. We describe how inflammatory signals act on the same cellular functions involved in normal tissue organization and homeostasis in order to coordinate emergency responses to perturbations and ultimately return the system to a homeostatic state. Finally, we consider the hierarchy of homeostatic and inflammatory circuits and the implications for the development of inflammatory diseases.

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6

Ziambaras, Konstantinos, Roberto Civitelli, and Stathis Papavasiliou. "Weightlessness and skeleton homeostasis." HORMONES 4, no. 1 (January 15, 2005): 18–27. http://dx.doi.org/10.14310/horm.2002.11139.

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7

S Prasad, Sanath. "Homeostasis - Balance, Equity, Equilibrium." International Journal of Science and Research (IJSR) 13, no. 3 (March 5, 2024): 1742–43. http://dx.doi.org/10.21275/es24326161131.

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8

Sumner, T., J. Hetherington, R. M. Seymour, L. Li, M. Varela Rey, S. Yamaji, P. Saffrey, et al. "A composite computational model of liver glucose homeostasis. II. Exploring system behaviour." Journal of The Royal Society Interface 9, no. 69 (February 8, 2012): 701–6. http://dx.doi.org/10.1098/rsif.2011.0783.

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Using a composite model of the glucose homeostasis system, consisting of seven interconnected submodels, we enumerate the possible behaviours of the model in response to variation of liver insulin sensitivity and dietary glucose variability. The model can reproduce published experimental manipulations of the glucose homeostasis system and clearly illustrates several important properties of glucose homeostasis—boundedness in model parameters of the region of efficient homeostasis, existence of an insulin sensitivity that allows effective homeostatic control and the importance of transient and oscillatory behaviour in characterizing homeostatic failure. Bifurcation analysis shows that the appearance of a stable limit cycle can be identified.

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9

Zhang, Huimin, Yang Li, Xiani Yao, Gang Liang, and Diqiu Yu. "POSITIVE REGULATOR OF IRON HOMEOSTASIS1, OsPRI1, Facilitates Iron Homeostasis." Plant Physiology 175, no. 1 (July 27, 2017): 543–54. http://dx.doi.org/10.1104/pp.17.00794.

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10

Pelletier, Luc G., Camille Guertin, J. Paige Pope, and Meredith Rocchi. "Homeostasis balance, homeostasis imbalance or distinct motivational processes? Comments on Marks (2015) ‘Homeostatic Theory of Obesity’." Health Psychology Open 3, no. 1 (January 13, 2016): 205510291562451. http://dx.doi.org/10.1177/2055102915624512.

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11

Gainey, Melanie A., and Daniel E. Feldman. "Multiple shared mechanisms for homeostatic plasticity in rodent somatosensory and visual cortex." Philosophical Transactions of the Royal Society B: Biological Sciences 372, no. 1715 (March 5, 2017): 20160157. http://dx.doi.org/10.1098/rstb.2016.0157.

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We compare the circuit and cellular mechanisms for homeostatic plasticity that have been discovered in rodent somatosensory (S1) and visual (V1) cortex. Both areas use similar mechanisms to restore mean firing rate after sensory deprivation. Two time scales of homeostasis are evident, with distinct mechanisms. Slow homeostasis occurs over several days, and is mediated by homeostatic synaptic scaling in excitatory networks and, in some cases, homeostatic adjustment of pyramidal cell intrinsic excitability. Fast homeostasis occurs within less than 1 day, and is mediated by rapid disinhibition, implemented by activity-dependent plasticity in parvalbumin interneuron circuits. These processes interact with Hebbian synaptic plasticity to maintain cortical firing rates during learned adjustments in sensory representations. This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’.

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12

Shalaby, Adel. "HOMEOSTASIS." Al-Azhar Medical Journal 48, no. 3 (July 1, 2019): 1. http://dx.doi.org/10.21608/amj.2019.56672.

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13

Slutsky, Inna, Gerhard Schratt, Guy-Bart Stan, Sacha Nelson, and Frank J. Bruggeman. "Homeostasis." Cell Systems 12, no. 12 (December 2021): 1124–26. http://dx.doi.org/10.1016/j.cels.2021.11.002.

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14

Vich Pérez, P. "Homeostasis." SEMERGEN - Medicina de Familia 41, no. 4 (May 2015): 181–82. http://dx.doi.org/10.1016/j.semerg.2015.03.005.

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15

Vella, F. "Homeostasis." Biochemical Education 13, no. 1 (January 1985): 41. http://dx.doi.org/10.1016/0307-4412(85)90146-3.

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16

Dharmmapornpilas, J. "Homeostasis." Chulalongkorn Medical Journal 41, no. 7 (July 1, 1997): 497–98. http://dx.doi.org/10.56808/2673-060x.3941.

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17

Rajkumar, R. Vinodh. "Accurate Interpretation of Stability of Human Health and Ageing Trajectory through a Single Objective Measure of Homeostasis." International Journal of Science and Healthcare Research 7, no. 3 (August 6, 2022): 120–29. http://dx.doi.org/10.52403/ijshr.20220719.

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Health stability is directly proportional to homeostatic stability. Overall efficiency of our body, both at rest and during physical activity, is the product of homeostasis. Human body is a magnificent interconnection and collaboration of various specialized cells and organs, capable of naturally obstructing and overcoming diseases with optimal survival competence. Homeostasis at rest and during exercise are mutually dependent/benefitting physiology that ensure and enhance the stability of human health and healthy ageing trajectory. Homeostasis enables us to withstand even major dysfunctions or disabilities by virtue of its individual-specific adaptability to unexpected challenges to survive. On the other hand, homeostasis has been almost a completely forgotten fundamental of physiology in all the aspects of health care. Numerous diagnostic tests have been available to assess multiple physiologic parameters but quite often the results of each test are not unified to interpret the homeostatic condition of the individuals. Probably, this non-homeostatic approach to deal with human health and diseases led to pathogenic orientation instead of salutogenic orientation to move in a health-promoting direction as viewed by Aaron Antonovsky. Homeostasis cannot be understood solely by examining the functions of human body in resting conditions, thus, testing of homeostatic efficiency through structured and customized physical activity becomes crucial. Man has discovered precision units to measure overall efficiency of various machines, but astonishingly not yet a single objective measure for the overall efficiency of his body. Individual-specific longitudinal evaluation of the overall homeostatic efficiency of healthy and unhealthy individuals on the basis of exercise performance still remains as an under-developed domain in medical profession. This article attempts to (i) validate the importance of accurately interpreting the stability and instability of human health and ageing trajectory using ‘exercise performance’, and (ii) establish ‘Tolerating Increasable Measurable Exercises - (TIME)’ as the most credible and indispensable objective measure of homeostasis. Keywords: Homeostasis, Exercise Physiology, Exercise Tolerance, Exercise Performance

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18

Curtsinger, James W. "Reproductive Homeostasis and Senescence in Drosophila melanogaster." Journals of Gerontology: Series A 74, no. 10 (December 6, 2018): 1533–38. http://dx.doi.org/10.1093/gerona/gly274.

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Abstract The homeostatic properties of reproduction in aging female Drosophila melanogaster are investigated. Classic studies based on cohort analysis suggest that homeostatic capacity declines gradually as daily oviposition rates decline in aging flies. Analysis at the level of individuals gives a very different picture: reproductive homeostasis remains relatively constant for most of adult life until a critical point when oviposition either ceases entirely or continues in dysregulated fashion. The collapse of homeostatic capacity is abrupt. Enhanced homeostasis is associated with increased lifetime fecundity and improved prospects for survival. The fractal concept of lacunarity can be used to parameterize the “roughness” of individual fecundity trajectories and is inversely related to homeostatic capacity.

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19

Lam, Carol K. L., Madhu Chari, and Tony K. T. Lam. "CNS Regulation of Glucose Homeostasis." Physiology 24, no. 3 (June 2009): 159–70. http://dx.doi.org/10.1152/physiol.00003.2009.

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The past decade has hosted a remarkable surge in research dedicated to the central control of homeostatic mechanisms. Evidence indicates that the brain, in particular the hypothalamus, directly senses hormones and nutrients to initiate behavioral and metabolic responses to control energy and nutrient homeostasis. Diabetes is chiefly characterized by hyperglycemia due to impaired glucose homeostatic regulation, and a primary therapeutic goal is to lower plasma glucose levels. As such, in this review, we highlight the role of the hypothalamus in the regulation of glucose homeostasis in particular and discuss the cellular and molecular mechanisms by which this neural pathway is orchestrated.

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20

Clancy, John, and Andrew McVicar. "Homeostasis 2: Nurses as external agents of homeostatic control." British Journal of Nursing 20, no. 4 (February 23, 2011): 232–38. http://dx.doi.org/10.12968/bjon.2011.20.4.232.

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21

Collins, Tim. "Pathophysiology, Homeostasis and NursingPathophysiology, Homeostasis and Nursing." Nursing Standard 18, no. 34 (May 5, 2004): 26. http://dx.doi.org/10.7748/ns2004.05.18.34.26.b381.

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22

Modell, Harold, William Cliff, Joel Michael, Jenny McFarland, Mary Pat Wenderoth, and Ann Wright. "A physiologist's view of homeostasis." Advances in Physiology Education 39, no. 4 (December 2015): 259–66. http://dx.doi.org/10.1152/advan.00107.2015.

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Homeostasis is a core concept necessary for understanding the many regulatory mechanisms in physiology. Claude Bernard originally proposed the concept of the constancy of the “milieu interieur,” but his discussion was rather abstract. Walter Cannon introduced the term “homeostasis” and expanded Bernard's notion of “constancy” of the internal environment in an explicit and concrete way. In the 1960s, homeostatic regulatory mechanisms in physiology began to be described as discrete processes following the application of engineering control system analysis to physiological systems. Unfortunately, many undergraduate texts continue to highlight abstract aspects of the concept rather than emphasizing a general model that can be specifically and comprehensively applied to all homeostatic mechanisms. As a result, students and instructors alike often fail to develop a clear, concise model with which to think about such systems. In this article, we present a standard model for homeostatic mechanisms to be used at the undergraduate level. We discuss common sources of confusion (“sticky points”) that arise from inconsistencies in vocabulary and illustrations found in popular undergraduate texts. Finally, we propose a simplified model and vocabulary set for helping undergraduate students build effective mental models of homeostatic regulation in physiological systems.

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23

Lomeli, Naomi, Daniela A. Bota, and Kelvin J. A. Davies. "Diminished stress resistance and defective adaptive homeostasis in age-related diseases." Clinical Science 131, no. 21 (October 25, 2017): 2573–99. http://dx.doi.org/10.1042/cs20160982.

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Adaptive homeostasis is defined as the transient expansion or contraction of the homeostatic range following exposure to subtoxic, non-damaging, signaling molecules or events, or the removal or cessation of such molecules or events (Mol. Aspects Med. (2016) 49, 1–7). Adaptive homeostasis allows us to transiently adapt (and then de-adapt) to fluctuating levels of internal and external stressors. The ability to cope with transient changes in internal and external environmental stress, however, diminishes with age. Declining adaptive homeostasis may make older people more susceptible to many diseases. Chronic oxidative stress and defective protein homeostasis (proteostasis) are two major factors associated with the etiology of age-related disorders. In the present paper, we review the contribution of impaired responses to oxidative stress and defective adaptive homeostasis in the development of age-associated diseases.

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24

Rajkumar, R. Vinodh. "Homeostaticology, Iatrogenicology and Salutogenicology." International Journal of Physiotherapy and Research 10, no. 2 (April 11, 2022): 4188–203. http://dx.doi.org/10.16965/ijpr.2022.115.

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Health may not be a perfect balance point but efforts can be made to maintain the health in a perfect homeostatic range. Disrupted homeostasis is the underlying issue of all the diseases. Larger and longer the deviations of the body from homeostatic conditions, poorer the ability to regain the original functions will be. George E Billman stated ‘Homeostasis: The Underappreciated and Far Too Often Ignored Central Organizing Principle of Physiology'. Lack of clinical diagnosis and treatments on the basis of homeostasis could lead to public health damage, disingenuous medical curriculum, and eventually iatrogenic pseudoscience. Ivan Illich criticized iatrogenesis caused by treatments, health policies, medicalization of life and eradication of autonomous coping skills during illnesses. Antonovsky distinctly stated the salutogenesis was not limited by the disciplinary borders of one profession but rather an interdisciplinary approach and a question of bringing coherence between disciplines and realise what connects them through the people’s ability to comprehend the whole situation and the capacity to use the resources available [called as sense of coherence - SOC] to move in a health promoting direction. Prevention or healing of homeostatic disturbances obviously need interdisciplinary approach of various medical specializations including Physiotherapy. Intensifying impeccable prophylaxis, clinical applications and public health policies on the basis of homeostasis need in-depth and persistent emphasis on ‘Homeostaticology’, ‘Iatrogenicology’ and ‘Salutogenicology’. KEY WORDS: Homeostasis, Iatrogenesis, Public health, Kinanthropometry, Salutogenesis, Stress, Eustress, Epigenetics, Exercise, Spiritual intelligence, Yerkes-Dodson Law.

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25

Duncan, William, and Martin Golubitsky. "Coincidence of Homeostasis and Bifurcation in Feedforward Networks." International Journal of Bifurcation and Chaos 29, no. 13 (December 10, 2019): 1930037. http://dx.doi.org/10.1142/s0218127419300374.

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Homeostasis is an important and common biological phenomenon wherein an output variable does not change very much as an input parameter is varied over an interval. It can be studied by restricting attention to homeostasis points — points where the output variable has a vanishing derivative with respect to the input parameter. In a feedforward network, if a node has a homeostasis point then downstream nodes will inherit it. This is the case except when the downstream node has a bifurcation point coinciding with the homeostasis point. We apply singularity theory to study the behavior of the downstream node near these homeostasis-bifurcation points. The unfoldings of low codimension homeostasis-bifurcation points are found. In the case of steady-state bifurcation, the behavior includes multiple homeostatic plateaus separated by hysteretic switches. In the case of Hopf bifurcation, the downstream node may have limit cycles with a wide range of near-constant amplitudes and periods. Homeostasis-bifurcation is therefore a mechanism by which binary, switch-like responses or stable clock rhythms could arise in biological systems.

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26

Kim, Ji-Yong, Yong Ju Yun, Joshua Jeong, C. Yoon Kim, Klaus-Robert Müller, and Seong-Whan Lee. "Leaf-inspired homeostatic cellulose biosensors." Science Advances 7, no. 16 (April 2021): eabe7432. http://dx.doi.org/10.1126/sciadv.abe7432.

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An incompatibility between skin homeostasis and existing biosensor interfaces inhibits long-term electrophysiological signal measurement. Inspired by the leaf homeostasis system, we developed the first homeostatic cellulose biosensor with functions of protection, sensation, self-regulation, and biosafety. Moreover, we find that a mesoporous cellulose membrane transforms into homeostatic material with properties that include high ion conductivity, excellent flexibility and stability, appropriate adhesion force, and self-healing effects when swollen in a saline solution. The proposed biosensor is found to maintain a stable skin-sensor interface through homeostasis even when challenged by various stresses, such as a dynamic environment, severe detachment, dense hair, sweat, and long-term measurement. Last, we demonstrate the high usability of our homeostatic biosensor for continuous and stable measurement of electrophysiological signals and give a showcase application in the field of brain-computer interfacing where the biosensors and machine learning together help to control real-time applications beyond the laboratory at unprecedented versatility.

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27

Wan, Yan, and Bingkun Zhang. "The Impact of Zinc and Zinc Homeostasis on the Intestinal Mucosal Barrier and Intestinal Diseases." Biomolecules 12, no. 7 (June 27, 2022): 900. http://dx.doi.org/10.3390/biom12070900.

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Zinc is an essential trace element for living organisms, and zinc homeostasis is essential for the maintenance of the normal physiological functions of cells and organisms. The intestine is the main location for zinc absorption and excretion, while zinc and zinc homeostasis is also of great significance to the structure and function of the intestinal mucosal barrier. Zinc excess or deficiency and zinc homeostatic imbalance are all associated with many intestinal diseases, such as IBD (inflammatory bowel disease), IBS (irritable bowel syndrome), and CRC (colorectal cancer). In this review, we describe the role of zinc and zinc homeostasis in the intestinal mucosal barrier and the relevance of zinc homeostasis to gastrointestinal diseases.

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28

Salcido, Celina A., Maxine K. Geltmeier, and Perry N. Fuchs. "Pain and Decision-Making: Interrelated Through Homeostasis." Open Pain Journal 11, no. 1 (December 31, 2018): 31–40. http://dx.doi.org/10.2174/1876386301811010031.

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Background:Pain is a multidimensional experience that motivates organisms to engage in behavioral repertoire to deal with potential life-threatening situations that are a threat to homeostatic function. The aim of this mini-review was to highlight the nature of pain, the role that pain has as a motivational drive to impact higher-order cognitive processes, such as decision making, and how these processes are intimately integrated with homeostatic mechanisms.Conclusion:Both conceptual and neurobiological overlap suggest a close interaction of decision-making, pain, and homeostasis. Pain, decision-making and homeostasis are interconnected through a common denominator of survival and must be considered when assessing pain-related issues and treatments.

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29

Charneski, Catherine A. "Heme homeostasis." Science 372, no. 6544 (May 20, 2021): 803.19–805. http://dx.doi.org/10.1126/science.372.6544.803-s.

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30

Boden, Scott D., and Frederick S. Kaplan. "Calcium Homeostasis." Orthopedic Clinics of North America 21, no. 1 (January 1990): 31–42. http://dx.doi.org/10.1016/s0030-5898(20)31563-7.

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31

Danziger, John, and Mark L. Zeidel. "Osmotic Homeostasis." Clinical Journal of the American Society of Nephrology 10, no. 5 (July 30, 2014): 852–62. http://dx.doi.org/10.2215/cjn.10741013.

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32

Etherington, J. R., and P. Trojan. "Ecosystem Homeostasis." Journal of Ecology 73, no. 2 (July 1985): 725. http://dx.doi.org/10.2307/2260526.

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33

Guo, Shanshan, David M. Frazer, and Gregory J. Anderson. "Iron homeostasis." Current Opinion in Clinical Nutrition & Metabolic Care 19, no. 4 (July 2016): 276–81. http://dx.doi.org/10.1097/mco.0000000000000285.

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Burkhead, Jason L., Kathryn A. Gogolin Reynolds, Salah E. Abdel-Ghany, Christopher M. Cohu, and Marinus Pilon. "Copper homeostasis." New Phytologist 182, no. 4 (April 23, 2009): 799–816. http://dx.doi.org/10.1111/j.1469-8137.2009.02846.x.

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35

Saris, D. B. F., W. J. A. Dhert, and A. J. Verbout. "Joint homeostasis." Journal of Bone and Joint Surgery. British volume 85-B, no. 7 (September 2003): 1067–76. http://dx.doi.org/10.1302/0301-620x.85b7.13745.

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36

Vokes, T. "Water Homeostasis." Annual Review of Nutrition 7, no. 1 (July 1987): 383–406. http://dx.doi.org/10.1146/annurev.nu.07.070187.002123.

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37

Bath, P. M. W. "Optimising homeostasis." British Medical Bulletin 56, no. 2 (January 1, 2000): 422–35. http://dx.doi.org/10.1258/0007142001903067.

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38

Eyre, David, and David J. Schurman. "Pathogenesis/Homeostasis." Clinical Orthopaedics and Related Research 427 (October 2004): S104. http://dx.doi.org/10.1097/01.blo.0000144978.73030.b7.

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39

Bray, G. A. "Weight Homeostasis." Annual Review of Medicine 42, no. 1 (February 1991): 205–16. http://dx.doi.org/10.1146/annurev.me.42.020191.001225.

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40

Lindeman, K. S., C. A. Hirshman, and A. N. Freed. "CALCIUM HOMEOSTASIS." Anesthesiology 71, Supplement (September 1989): A880. http://dx.doi.org/10.1097/00000542-198909001-00880.

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41

Rodan, G. A. "Bone homeostasis." Proceedings of the National Academy of Sciences 95, no. 23 (November 10, 1998): 13361–62. http://dx.doi.org/10.1073/pnas.95.23.13361.

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42

Davies, Kelvin J. A. "Adaptive homeostasis." Molecular Aspects of Medicine 49 (June 2016): 1–7. http://dx.doi.org/10.1016/j.mam.2016.04.007.

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43

O'Neill, PA. "Aging homeostasis." Reviews in Clinical Gerontology 7, no. 3 (August 1997): 199–211. http://dx.doi.org/10.1017/s095925989700734x.

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Homeostasis is the ability of a living organism to control its internal environment despite fluctuations in the external environment. Claude Bernard proposed the concept of 'milieu interieur'. The hypothesis rests on the belief that cells need a precisely defined local environment in which to function optimally. The maintenance of the micro-environment is dependent on integration of the systems of the organism (body), including behaviour, to protect the cell(s) from external stressors. When the environment changes, the body needs to sense the alteration, then set in motion mechanisms which mitigate the change and restore the previous balance. If it fails to do this, the organism will ultimately die as systems fail.

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44

Borbély, Alexander A. "Sleep homeostasis." Behavioral and Brain Sciences 9, no. 3 (September 1986): 401. http://dx.doi.org/10.1017/s0140525x00046239.

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45

Franekova, V., G. Leivseth, and O. Nilssen. "MUSCLE HOMEOSTASIS." Neuromuscular Disorders 29 (October 2019): S85. http://dx.doi.org/10.1016/j.nmd.2019.06.181.

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46

Macara, Ian G., Richard Guyer, Graham Richardson, Yongliang Huo, and Syed M. Ahmed. "Epithelial Homeostasis." Current Biology 24, no. 17 (September 2014): R815—R825. http://dx.doi.org/10.1016/j.cub.2014.06.068.

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47

Porkka-Heiskanen, Tarja. "Sleep homeostasis." Current Opinion in Neurobiology 23, no. 5 (October 2013): 799–805. http://dx.doi.org/10.1016/j.conb.2013.02.010.

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48

Nordin, B. E. C. "Calcium homeostasis." Clinical Biochemistry 23, no. 1 (February 1990): 3–10. http://dx.doi.org/10.1016/0009-9120(90)90309-i.

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49

Andrews, Nancy C., and Paul J. Schmidt. "Iron Homeostasis." Annual Review of Physiology 69, no. 1 (March 2007): 69–85. http://dx.doi.org/10.1146/annurev.physiol.69.031905.164337.

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50

Tobler, Irene, and Peter Achermann. "Sleep homeostasis." Scholarpedia 2, no. 10 (2007): 2432. http://dx.doi.org/10.4249/scholarpedia.2432.

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