Log in

Relevant bibliographies by topics / HMN / Journal articles

Journal articles on the topic 'HMN'

To see the other types of publications on this topic, follow the link: HMN.

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'HMN.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Previtali, Stefano C., Edward Zhao, Dejan Lazarevic, Giovanni Battista Pipitone, Gian Maria Fabrizi, Fiore Manganelli, Anna Mazzeo, et al. "Expanding the spectrum of genes responsible for hereditary motor neuropathies." Journal of Neurology, Neurosurgery & Psychiatry 90, no. 10 (June 5, 2019): 1171–79. http://dx.doi.org/10.1136/jnnp-2019-320717.

Full text

Abstract:

BackgroundInherited peripheral neuropathies (IPNs) represent a broad group of genetically and clinically heterogeneous disorders, including axonal Charcot-Marie-Tooth type 2 (CMT2) and hereditary motor neuropathy (HMN). Approximately 60%–70% of cases with HMN/CMT2 still remain without a genetic diagnosis. Interestingly, mutations in HMN/CMT2 genes may also be responsible for motor neuron disorders or other neuromuscular diseases, suggesting a broad phenotypic spectrum of clinically and genetically related conditions. Thus, it is of paramount importance to identify novel causative variants in HMN/CMT2 patients to better predict clinical outcome and progression.MethodsWe designed a collaborative study for the identification of variants responsible for HMN/CMT2. We collected 15 HMN/CMT2 families with evidence for autosomal recessive inheritance, who had tested negative for mutations in 94 known IPN genes, who underwent whole-exome sequencing (WES) analyses. Candidate genes identified by WES were sequenced in an additional cohort of 167 familial or sporadic HMN/CMT2 patients using next-generation sequencing (NGS) panel analysis.ResultsBioinformatic analyses led to the identification of novel or very rare variants in genes, which have not been previously associated with HMN/CMT2 (ARHGEF28, KBTBD13, AGRN and GNE); in genes previously associated with HMN/CMT2 but in combination with different clinical phenotypes (VRK1 and PNKP), and in the SIGMAR1 gene, which has been linked to HMN/CMT2 in only a few cases. These findings were further validated by Sanger sequencing, segregation analyses and functional studies.ConclusionsThese results demonstrate the broad spectrum of clinical phenotypes that can be associated with a specific disease gene, as well as the complexity of the pathogenesis of neuromuscular disorders.

APA, Harvard, Vancouver, ISO, and other styles

2

Okada, Youhei, Hisayuki Yokokura, Qsamu Terada, Mami Nomura, Yuji Iida, Tomohiko bhikawa, Ichiro Niki, and Hiroyoshi Hidaka. "THE NOVEL CALMODULIN ANTAGONIST HMN-709B." Japanese Journal of Pharmacology 67 (1995): 105. http://dx.doi.org/10.1016/s0021-5198(19)46386-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Chilamakuri, Rameswari, Danielle Crystal Rouse, and Saurabh Agarwal. "Inhibition of Polo-like Kinase 1 by HMN-214 Blocks Cell Cycle Progression and Inhibits Neuroblastoma Growth." Pharmaceuticals 15, no. 5 (April 24, 2022): 523. http://dx.doi.org/10.3390/ph15050523.

Full text

Abstract:

Polo-like kinase 1 (PLK1) is an essential cell cycle mitotic kinase component that plays an important role in cell cycle progression and has been reported to be involved in various cancers, including neuroblastoma (NB). PLK1 also regulates G2/M transition, chromosomal segregation, spindle assembly maturation, and mitotic exit. NB is an early embryonic-stage heterogeneous solid tumor and accounts for 15% of all pediatric cancer-related deaths. Therefore, we aimed to develop a targeting strategy for PLK1 by repurposing HMN-214 in NB. HMN-214 is a prodrug of HMN-176 and is known to selectively interfere with PLK1 function. In the present study, we performed the transcriptomic analysis of a large cohort of primary NB patient samples and revealed that PLK1 expression is inversely correlated with the overall survival of NB patients. Additionally, we found that PLK1 strongly correlates with NB disease and stage progression. HMN-214 significantly inhibited NB proliferation and colony formation in both MYCN-amplified and -nonamplified cell lines in a dose-dependent manner. Furthermore, HMN-214 induces apoptosis and significantly obstructs the cell cycle at the G2/M phase in NB cells by inhibiting multiple cell-cycle-related genes, such as PLK1, WEE1, CDK1, CDK2, Cyclin B1, CHK1, and CHK2. HMN-214 significantly inhibits cell cycle regulator CDK1 and the phosphorylation and activation of PLK1 in NB. In the NB 3D spheroid tumor model, HMN-214 significantly and in a dose-dependent manner inhibits spheroid tumor mass and growth. Overall, our study highlights that targeting PLK1 using HMN-214 is a novel therapeutic approach for NB.

APA, Harvard, Vancouver, ISO, and other styles

4

Cho, Chulho, Seongkil Nam, Sunghoon Yu, Myeonghwan Choi, and Namhyun Kang. "Mechanical and Microstructural Behaviors of Gas Tungsten Arc Dissimilar Metal Welds of High-Mn Steel and Stainless Steel 316L Using Various Fillers for Cryogenic Fuel Tanks." Korean Journal of Metals and Materials 60, no. 9 (September 5, 2022): 673–84. http://dx.doi.org/10.3365/kjmm.2022.60.9.673.

Full text

Abstract:

The gas tungsten arc (GTA) weldability of high-Mn (HMn) steel and austenitic stainless steel (STS) 316L using dissimilar metal welds (DMWs) was investigated, to fabricate a fuel tank for an LNG-fueled ship. Three types of welding fillers, HMn steel, STS 309LMo and Inconel 625, were applied to the DMWs. The weldability of the DMWs was examined by investigating mechanical properties at 25 and -196 o C, followed by microstructural evolution and weld deformation. The GTA welding process was performed with a heat input range of 0.72–1.89 kJ/mm. All of the fillers employed in the study produced reasonable mechanical properties and low levels of precipitation, such as M<sub>7</sub>C<sub>3</sub> and Fe<sub>3</sub>C. However, the DN specimen using the Inconel 625 filler exhibited reduced ductility in the bending test. This was attributed to Nb-carbide precipitations at dendrite boundaries at the root weld. The DM specimen using HMn filler experienced severe thermal deformation because it had a relatively higher coefficient of thermal expansion than the other fillers during heating by arc and solidification. Therefore, STS 309LMo and HMn wires were determined to be the appropriate fillers for the DMW of HMn steel and STS 316L for cryogenic applications, and the HMn wire requires attention to weld deformation.

APA, Harvard, Vancouver, ISO, and other styles

5

Singh, Madan, Benedict M. Taele, Sekhantso Lara, Sanjay Kumar Singhal, and Kamal Devlal. "Modeling thermodynamic properties of Ni, Sn, Al and Cu nanosolids." High Temperatures-High Pressures 51, no. 5 (2022): 403–18. http://dx.doi.org/10.32908/hthp.v51.1263.

Full text

Abstract:

Surface atoms and dangling bonds on the surface affect the thermodynamic properties. A thermodynamical model, based on cohesive energy is presented to discuss the melting properties of materials at nanoscale. The model is used to realize the effect of size and shape on melting temperature Tmn, melting entropy Smn and enthalpy Hmn of Ni, Sn, Al and Cu metallic nanoparticles. The variation in Tmn, Smn and Hmn are examined for nanowire, film, spherical, regular tetrahedral, hexahedral and octahedral shaped nanoparticles. It is reported that Tmn, Smn and Hmn decrease with decreasing the size of the nanoparticles and smaller the particle size, greater are the size and shape effects and when size is less than 10 nm, it has been predicted that on decreasing size, Tmn, Smn and Hmn reduce appreciably. Also, at the same size, more the shape of nanoparticles departs from that of the sphere, smaller is the Smn and Hmn of nanoparticles and its changes are less for nanowire shape and more for regular tetrahedral shape. Our theoretical results are compared with the available experimental or simulation data. Results predicted by our model are in good agreement with experimental observations.

APA, Harvard, Vancouver, ISO, and other styles

6

Cahyana, Intan Nevia. "Sebuah Kajian Yuridis tentang Konsep Hak Mengenai Negara (HMN) berdasarkan Undang-undang Pokok Agraria (UUPA) dalam Penerapan Pasar Bebas." Jurnal Hukum PRIORIS 5, no. 3 (January 31, 2017): 245–64. http://dx.doi.org/10.25105/prio.v5i3.1433.

Full text

Abstract:

Pasal 33 ayat (3) Undang-undang Dasar 1945 berbunyi :"Bumi, air dan kekayaan alam yang terkandung didalamnya dikuasai oleh negara dan, dipergunakan untuk sebesar-besarnya kemakmuran rakyat." Konsep ini dikenal sebagai konsep Hak Menguasai Negara (HMN).Dengan demikian, politik agraria Indonesia berpusat pada kekuasaan yang besar dari negara terhadap penguasaan, pemilikan dan pemanfaatan sumber-sumber agraria.Cita-cita ideal yang terkandung di dalam konsep HMN adalah menempatkan negara sebagai sentral yang mengatur pemanfaatan kekayaan negeri untuk kemakmuran rakyat. Ironisnya untuk mewujudakan cita-cita ideal ini konsep HMN politik hukum agraria mengembangkan proses marginalisasi posisi UUPA 1960. Ideologi "pembangunan" atau developmentalism menjadi pemandu politik agraria yang dikelola secara sentralistik-sektoral tidak lain adalah kapitalisme, yang kini muncul dan berkembang sebagai sebuah kekuatan ekonomi politik yang megarah kepada praktek pasar bebas dimana tidak menghendaki peran Negara. Negara membiarkan mekanisme pasar mengatur produksi, distribusi maupun konsumsi.Dalam konteks pembangunan agraria yang harus ditelusuri lebih jauh adalah bagaimana hubungan konsep HMN berdasarkan UUPA dengan pasar bebas dan bagaimana pula pengaruh pasar bebas terhadap peran negara menurut konsep HMN berdasarkan UUPA.Penelitian ini menggunakan metode penelitian normatif dan data yang diperoleh kemudian dianalisis dengan pendekatan kualitatif.Pada akhirnya melalui penerapan pasar bebas bukanlah kemakmuran global yang dicapai, melainkan situasi perekonomian dunia secara umum yang semakin terpuruk akibat dominasi Negara maju atas Negara berkembang. Di Indonesia pasar bebas akan membawa dampak negatif bagi keberadaan UUPA yang bersifat populis dan menghendaki peran Negara melalui konsep Hak Menguasai Negara berdasarkan pasal 2 UUPA.Kata Kunci : Konsep Hak Menguasai Negara (HMN), Pasar Bebas

APA, Harvard, Vancouver, ISO, and other styles

7

Lai, Helang, Keke Wu, and Lingli Li. "Multimodal emotion recognition with hierarchical memory networks." Intelligent Data Analysis 25, no. 4 (July 9, 2021): 1031–45. http://dx.doi.org/10.3233/ida-205183.

Full text

Abstract:

Emotion recognition in conversations is crucial as there is an urgent need to improve the overall experience of human-computer interactions. A promising improvement in this field is to develop a model that can effectively extract adequate contexts of a test utterance. We introduce a novel model, termed hierarchical memory networks (HMN), to address the issues of recognizing utterance level emotions. HMN divides the contexts into different aspects and employs different step lengths to represent the weights of these aspects. To model the self dependencies, HMN takes independent local memory networks to model these aspects. Further, to capture the interpersonal dependencies, HMN employs global memory networks to integrate the local outputs into global storages. Such storages can generate contextual summaries and help to find the emotional dependent utterance that is most relevant to the test utterance. With an attention-based multi-hops scheme, these storages are then merged with the test utterance using an addition operation in the iterations. Experiments on the IEMOCAP dataset show our model outperforms the compared methods with accuracy improvement.

APA, Harvard, Vancouver, ISO, and other styles

8

Lindner, Ekkehard, Paul Fisahn, Riad Fawzi, and Manfred Steimann. "Notizen: Darstellung und Eigenschaften von und Reaktionen mit metallhaltigen Heterocyclen, LXXXI Synthese und Kristallstruktur eines Phospha-arsa-mangana-cyclopropans / Metal-Containing Heterocycles: Preparation, Properties, and Reactions, LXXXI Synthesis and Crystal Structure of a Phospha-arsa-mangana-cyclopropane." Zeitschrift für Naturforschung B 47, no. 12 (December 1, 1992): 1798–800. http://dx.doi.org/10.1515/znb-1992-1226.

Full text

Abstract:

The phospha-arsa-mangana-cyclopropane (OC)4Mn–PPh2–AsAr (4) [Ar = 2,4,6-(t-Bu)3C6H2] is obtained in a one-pot reaction proceeding in the sequence Mn2(CO)10 → HMn(CO)5 (1) → HMn(CO)4PPh2H (2) → Li2[(OC)4Mn—⃛PPh2] (3) → 4. According to an X-ray structural analysis 4 has a short P–As bond (229 pm) and a long Mn–As distance (262 pm).

APA, Harvard, Vancouver, ISO, and other styles

9

Cao, Yune, Yanming Gao, Yongqiang Tian, and Jianshe Li. "Compost Addition Attenuates the Negative Impacts of High Soil Mineral Nitrogen Levels on Rhizosphere Microbial Characteristics and Enhances Cucumber Growth in Monoculture Systems." Plants 11, no. 13 (June 21, 2022): 1621. http://dx.doi.org/10.3390/plants11131621.

Full text

Abstract:

Due to the increase in the human population, it is necessary to seek efficient methods of increasing crop productivity and, simultaneously, sustaining the soil. One way is to grow high demand crops continuously without rotating with other crops. This practice is often accompanied by increased rates of fertilizer application that can affect efficient nitrogen (N) cycling in the plant rhizosphere soil which, in turn, affects both plant growth and environmental pollution. In the present study, twelve various cucumber soils were selected from monoculture systems presenting different cropping years and divided into two groups including soils with relatively high mineral N (HMN) content (N > 100 mg kg−1 soil) and those with a lower mineral N (LMN) content (N < 100 mg kg−1 soil). All soils were amended with the addition of compost alone or in combination with bacterial inoculation to evaluate their effects on plant growth, microbial numbers, N mineralization, and N cycling genes. In general, the HMN soils increased (p < 0.05) net N mineralization (NNM) but did not statistically (p > 0.05) affect plant biomass compared to the LMN soils; however, compost addition increased both NNM and plant biomass in the HMN soils. In addition, the HMN soils had higher fungal pathogen numbers (FPNs) but lower total microbial biomass (TMB) and bacterial numbers (BNs) compared to the LMN soils; however, compost addition decreased FPNs but increased TMB and BNs in the HMN soils (all p < 0.05). Plant biomass was positively related to TMB, BN and NNM but was negatively related to FPN (all p < 0.05). In summary, compost addition reduced the high mineral N levels’ adverse effects on the rhizosphere soil and plant growth.

APA, Harvard, Vancouver, ISO, and other styles

10

Morrison, Janna L., Sandeep Sood, Xia Liu, Hattie Liu, Eileen Park, Philip Nolan, and Richard L. Horner. "Glycine at hypoglossal motor nucleus: genioglossus activity, CO2 responses, and the additive effects of GABA." Journal of Applied Physiology 93, no. 5 (November 1, 2002): 1786–96. http://dx.doi.org/10.1152/japplphysiol.00464.2002.

Full text

Abstract:

There is evidence for glycine and GABAA-receptor-mediated inhibition of hypoglossal motoneurons in vitro. However, comparable studies have not been performed in vivo, and the interactions of such mechanisms with integrative reflex respiratory control have also not been determined. This study tests the hypotheses that glycine at the hypoglossal motor nucleus (HMN) will suppress genioglossus (GG) muscle activity, even in the presence of hypercapnic respiratory stimulation, and the effects of glycine will be blocked by strychnine. We also determined whether coapplication of glycine and muscimol (GABAA- receptor agonist) to the HMN is additive in suppressing GG activity. Twenty-four urethane-anesthetized, tracheotomized, and vagotomized rats were studied. Diaphragm and GG activities, the electroencephalogram, and blood pressure were recorded. Microdialysis probes were implanted into the HMN for delivery of artificial cerebrospinal fluid (control), glycine (0.0001–10 mM), or muscimol (0.1 μM). Increasing glycine at the HMN produced graded suppression of GG activity ( P < 0.001), although the GG still responded to stimulation with 7% inspired CO2( P = 0.002). Strychnine (0.1 mM) reversed the glycine-mediated suppression of GG activity, whereas combined glycine and muscimol were additive in GG muscle suppression. It remains to be determined whether the recruitment of such glycine and GABA mechanisms explains the periods of major GG suppression in behaviors such as rapid eye movement sleep.

APA, Harvard, Vancouver, ISO, and other styles

11

Medina-Gundrum, Leticia, Cesario Cerna, Lionel Gomez, and Elzbieta Izbicka. "Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression." Investigational New Drugs 23, no. 1 (January 2005): 3–9. http://dx.doi.org/10.1023/b:drug.0000047100.64540.f6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Sembiring, Julius. "Hak Menguasai Negara Atas Sumber Daya Agraria." BHUMI: Jurnal Agraria dan Pertanahan 2, no. 2 (November 30, 2016): 119. http://dx.doi.org/10.31292/jb.v2i2.65.

Full text

Abstract:

Abstract: State’s possession of agrarian resources , called as State’s right of control is the authority of the State attained through the atribution principle of the 1945 Constitution. In the National Land Law, the State’s right of control is the delegation of the public’s right to the State to manage resources, and was called as the highest right of the nation. Based on this delegation, the State has the authority to formulate policies, execute regulations, and also to arrange, manage, and control agrarian resources. To avoid misconducts on the implementation of the State’s right of control, the State authorities are limited by 3 (three) aspects, which are: the objective of the right itself for the greatest prosperity of the people; individual right and legal entity; and ulayat right of land of traditional society. On the implementation, State’s right of control was delegated to particular authorities (agrarian/land, forestry, and mining agencies), in which these authorities issuing civil rights such as ‘land right’ and ‘land permit’. K K K K Keywor eywor eywor eywor eywords ds ds ds ds: state’s right of control, agrarian resources, delegation of authority.Intisari: Penguasaan negara atas sumber daya agraria (SDA) yang disebut dengan hak menguasai negara (HMN) merupakan wewenang yang diperoleh negara berdasarkan prinsip atribusi dari UUD 1945. Dalam konsepsi Hukum Tanah Nasional, HMN tersebut merupakan pelimpahan hak publik berupa amanat untuk mengelola dari Hak Bangsa – sebagai hak yang tertinggi – kepada negara. Atas dasar pelimpahan tersebut, negara berwewenang untuk merumuskan kebijakan, melakukan pengaturan, pengurusan, pengelolaan dan pengawasan terhadap SDA. Untuk menghindari kesewenang-wenangan dari HMN tersebut, maka kewenangan negara dibatasi oleh 3 (tiga) hal yaitu: oleh tujuan dari HMN itu sendiri yaitu untuk mencapai sebesar-besar kemakmuran rakyat; oleh hak perseorangan dan badan hukum; serta oleh hak ulayat masyarakat adat. Dalam pelaksanaannya HMN itu dilimpahkan pada otoritas tertentu (pertanahan, kehutanan, dan pertambangan) dan kemudian oleh otoritas tersebut diterbitkan hak yang berkarakter perdata seperti ‘hak atas tanah’ dan ‘izin’ kepada pihak tertentu. Kata kunci Kata kunci Kata kunci Kata kunci Kata kunci: hak menguasai negara, sumber daya agraria, pelimpahan wewenang

APA, Harvard, Vancouver, ISO, and other styles

13

Toyo, Eleonora Maryeta, Karol Giovani Battista Leki, Ferika Indarsari, and Suwito Woro. "Evaluasi Sistem Pelaporan Insiden Keselamatan Pasien Dengan Metode HMN Di Rumah Sakit." Majalah Farmasetika 8, no. 1 (October 22, 2022): 56. http://dx.doi.org/10.24198/mfarmasetika.v8i1.41357.

Full text

Abstract:

Keselamatan pasien di rumah sakit adalah sistem pelayanan yang memberikan asuhan pasien menjadi lebih aman dalam mengukur risiko, identifikasi dan pengelolahan risiko terhadap analisa insiden, kemampuan untuk belajar dan menidaklanjuti insiden serta menerapkan solusi untuk mengurangi risiko.Tujuan dalam penelitian ini adalah untuk mengevaluasi sistem pelaporan insiden keselamatan pasien dengan menggunakan metode HMN (Health Metrics Network) yang mencakup aspek segi input, segi proses, dan segi output. Penelitian ini merupakan studi deskriptif observasional dengan rancang bangun cross sectional dan data kualitatif. Pengumpulan data dilakukan dengan wawancara, observasi, dan telaah dokumen. Hasil dan kesimpulan penelitian menunjukkan bahwa komponen-komponen evaluasi sistem pelaporan insiden yaitu sumber daya sistem informasi kesehatan, indikator kesehatan, sumber data, manejemen data, produk informasi, dan penggunaan informasi kesehatan sudah sesuai dengan peraturan menteri kesehatan no. 11 tahun 2017 tentang keselamatan pasien dan buku panduan pelaporan insiden keselamatan pasien yang dikeluarkan oleh tim KKP-RS tahun 2015. Kata kunci: Keselamatan Pasien, Pelaporan Insiden, HMN, Rumah Sakit

APA, Harvard, Vancouver, ISO, and other styles

14

Zhang, Jia-Han, Yong Li, Jinhua Du, Xihong Hao, and Haitao Huang. "A high-power wearable triboelectric nanogenerator prepared from self-assembled electrospun poly(vinylidene fluoride) fibers with a heart-like structure." Journal of Materials Chemistry A 7, no. 19 (2019): 11724–33. http://dx.doi.org/10.1039/c9ta01956a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Li, Chuanzhao, Effendi Widjaja, and Marc Garland. "Rh4(CO)12-Catalyzed Hydroformylation of Cyclopentene Promoted with HMn(CO)5. Another Example of Rh4(CO)12/HMn(CO)5Bimetallic Catalytic Binuclear Elimination." Organometallics 23, no. 17 (August 2004): 4131–38. http://dx.doi.org/10.1021/om0342661.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

W, Widyaningsih, Lilis Suryani LS, and Heriziana H. "Evaluasi Sistem Informasi Kesehatan dengan Pendekatan Health Metrics Network di Dinas Kesehatan Kota Pagar Alam." Jurnal Kesehatan Saelmakers PERDANA 5, no. 1 (February 28, 2022): 97–103. http://dx.doi.org/10.32524/jksp.v5i1.394.

Full text

Abstract:

Data and information are strategic resources in health development and management. A health information system is considered effective if it can give information support in a decision making process through all levels. Health information system evaluation aims to ensure the efficiency of a health information system and its ability to provide quality information. The study aimed to determine description of health information system evaluation results in Pagar Alam Public Health Office. The study was carried on by using Health Metric Network (HMN) as tools. The study is a descriptive evaluative design with mixed method approach. The study subjects were 9 Health Information System workers in Pagar Alam Public Health Office. Study data was collected by doing interview and observation. Data analysis was done by using Health Metric Network (HMN) version 4.00. The result of health information system evaluation using six components within HMN instrument was within the range of 41-60% which means that the system exists but inadequate. The conclusion of this study is that health information system in Pagar Alam Public Health Office has been carried on well enough, but requires improvements in its data management

APA, Harvard, Vancouver, ISO, and other styles

17

Wood, Martyn D., Karen L. Murkitt, Michael Ho, Jeannette M. Watson, Frank Brown, A. Jacqueline Hunter, and Derek N. Middlemiss. "Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1 , hM2 , hM3 , hM4 and hM5 using microphysiometry." British Journal of Pharmacology 126, no. 7 (April 1999): 1620–24. http://dx.doi.org/10.1038/sj.bjp.0702463.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Huang, Tengfei, Wenjie Yu, Juanjuan Cheng, Fei Cong, Bing Xu, and Xuefeng Wang. "CO2 activation by ligand-free manganese hydrides in a parahydrogen matrix." Chemical Communications 57, no. 18 (2021): 2301–4. http://dx.doi.org/10.1039/d0cc08256b.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Pepper, T. M., J. J. Swanson, M. C. Kuehl-Kovarik, and CD Jacobson. "An Electron Microscopic Study of Developing Synapses in Facial and Hypoglossal Motor Nuclei of the Brazilian Opossum." Microscopy and Microanalysis 3, S2 (August 1997): 181–82. http://dx.doi.org/10.1017/s1431927600007790.

Full text

Abstract:

Previously, we have shown the apparent development of synapses utilizing immunohistochemistry (IHC) for synapse-associated proteins in the facial and hypoglossal motor nuclei of the Brazilian opossum. This study suggests that synaptogenesis is delayed in the facial motor nucleus (FMN) as compared to the hypoglossal motor nucleus (HMN). In the present study we plan to confirm and extend these findings at the electron microscopic (EM) level.We have examined the ultrastructure of the developing FMN from animals 5 to 25 days of postnatal age (PN). The specific nuclei were identified using methylene blue stained 150 μm thick vibratome cut sections. The FMN and HMN were then dissected out for processing, guaranteeing that visualization at the EM level would be confined to areas specific to the nuclei of interest.Initial analysis of the FMN indicates a marked increase of detectable synapses between 5 and 15PN.

APA, Harvard, Vancouver, ISO, and other styles

20

Langer, Thomas M., Suzanne E. Neumueller, Emma Crumley, Nicholas J. Burgraff, Sawan Talwar, Matthew R. Hodges, Lawrence Pan, and Hubert V. Forster. "Ventilation and neurochemical changes during µ-opioid receptor activation or blockade of excitatory receptors in the hypoglossal motor nucleus of goats." Journal of Applied Physiology 123, no. 6 (December 1, 2017): 1532–44. http://dx.doi.org/10.1152/japplphysiol.00592.2017.

Full text

Abstract:

Neuromodulator interdependence posits that changes in one or more neuromodulators are compensated by changes in other modulators to maintain stability in the respiratory control network. Herein, we studied compensatory neuromodulation in the hypoglossal motor nucleus (HMN) after chronic implantation of microtubules unilaterally ( n = 5) or bilaterally ( n = 5) into the HMN. After recovery, receptor agonists or antagonists in mock cerebrospinal fluid (mCSF) were dialyzed during the awake and non-rapid eye movement (NREM) sleep states. During day studies, dialysis of the µ-opioid inhibitory receptor agonist [d-Ala2, N-MePhe4, Gly-ol]enkephalin (DAMGO; 100 µM) decreased pulmonary ventilation (V̇i), breathing frequency ( f), and genioglossus (GG) muscle activity but did not alter neuromodulators measured in the effluent mCSF. However, neither unilateral dialysis of a broad spectrum muscarinic receptor antagonist (atropine; 50 mM) nor unilateral or bilateral dialysis of a mixture of excitatory receptor antagonists altered V̇i or GG activity, but all of these did increase HMN serotonin (5-HT) levels. Finally, during night studies, DAMGO and excitatory receptor antagonist decreased ventilatory variables during NREM sleep but not during wakefulness. These findings contrast with previous dialysis studies in the ventral respiratory column (VRC) where unilateral DAMGO or atropine dialysis had no effects on breathing and bilateral DAMGO or unilateral atropine increased V̇i and f and decreased GABA or increased 5-HT, respectively. Thus we conclude that the mechanisms of compensatory neuromodulation are less robust in the HMN than in the VRC under physiological conditions in adult goats, possibly because of site differences in the underlying mechanisms governing neuromodulator release and consequently neuronal activity, and/or responsiveness of receptors to compensatory neuromodulators. NEW & NOTEWORTHY Activation of inhibitory µ-opioid receptors in the hypoglossal motor nucleus decreased ventilation under physiological conditions and did not affect neurochemicals in effluent dialyzed mock cerebral spinal fluid. These findings contrast with studies in the ventral respiratory column where unilateral [d-Ala2, N-MePhe4, Gly-ol]enkephalin (DAMGO) had no effects on ventilation and bilateral DAMGO or unilateral atropine increased ventilation and decreased GABA or increased serotonin, respectively. Our data support the hypothesis that mechanisms that govern local compensatory neuromodulation within the brain stem are site specific under physiological conditions.

APA, Harvard, Vancouver, ISO, and other styles

21

Nishio, Masahiro, Yasuo Watanabe, and Hiroyoshi Hidaka. "HMN-1180, a specific small molecule inhibitor of neuronal nitric oxide synthase." Japanese Journal of Pharmacology 76 (1998): 273. http://dx.doi.org/10.1016/s0021-5198(19)41202-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Kukolich, Stephen G., and Shane M. Sickafoose. "The microwave spectrum and MnH bond length for HMn(CO)5." Chemical Physics Letters 215, no. 1-3 (November 1993): 168–72. http://dx.doi.org/10.1016/0009-2614(93)89282-m.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Yokokura, Hisayuki, Yohei Okada, Osamu Terada, and Hiroyoshi Hidaka. "HMN-709, a Chlorobenzenesulfonamide Derivative, Is a New Membrane-Permeable Calmodulin Antagonist." Japanese Journal of Pharmacology 72, no. 2 (1996): 127–35. http://dx.doi.org/10.1254/jjp.72.127.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Yang, Shan Shan, Xiong Liu, Jiang Nan Shen, and Cong Jie Gao. "Comparison Study of PVDF-HMn₂O₄ and PES-HMn₂O₄ Membrane-Type Adsorbents for Lithium Adsorption/Desorption." Applied Mechanics and Materials 633-634 (September 2014): 517–20. http://dx.doi.org/10.4028/www.scientific.net/amm.633-634.517.

Full text

Abstract:

Much attention has been paid to membrane-type lithium adsorbents to overcome the shortages of the leakage of powder, poor permeability and difficult recycle for powder lithium adsorbents. In this work, a series of membrane-type adsorbents of spinel-type manganese oxides were converted from lithium manganese oxide precursor membranes by acid treatment. Precursor membranes were prepared by solvent exchange method using polyvinylidene fluoride (PVDF) and Polyether sulphone (PES) respectively as binders, powder LiMn2O4 as the precursor and N,N-dimethyl acetamide (DMAc) as the solvent. The preparation conditions were investigated by changing the binder and the concentration of powder LiMn2O4. The surfaces and morphology of membrane-type adsorbents were observated by scanning electron microscope. The comparation of the capacities of lithium desorption from precursor and adsorption for membrane-type adsorbents based on different binders shows that PVDF is more suitable to be the binder than PES with liquid film thickness of 0.25mm, and the proper concentration of PVDF and powered LiMn2O4 are respectively 12% and 60%.

APA, Harvard, Vancouver, ISO, and other styles

25

Cortes Soriano, Isaí, María Ofelia Buendía González, Natalia Palacios Rojas, Eliel Martínez Cruz, Héctor Eduardo Villaseñor Mir, and René Hortelano Santa Rosa. "Evaluación de la calidad de tortilla de maíz adicionada con harina de avena (Avena Sativa L.) nixtamalizada." Revista Mexicana de Ciencias Agrícolas 7, no. 7 (August 31, 2017): 1715. http://dx.doi.org/10.29312/remexca.v7i7.164.

Full text

Abstract:

El consumo excesivo de harinas refinadas y refrescos es uno de los factores por los cuales hoy la población mexicana ocupa los primeros lugares en sobrepeso y obesidad a nivel mundial. El desarrollo y promoción del consumo de alimentos con mejor balance nutricional puede contribuir a revertir esta tendencia, al utilizar procesos y alimentos tradicionales de la cultura mexicana, como lo es la nixtamalizacion, y no solo de maíz, sino de otros granos con propiedades nutricionales reconocidas. El objetivo de esta investigación fue elaborar tortillas de mezclas de harina de maíz nixtamalizado (HMN) con harina de avena nixtamalizada (HAVN), realizar su análisis bromatológico y evaluar su calidad sensorial. La HAVN se obtuvo de la variedad Obsidiana y la HMN fue de la marca MINSA®. Las mezclas evaluadas de HAVN:HMN fueron 10:90, 20:80, 30:70 y 40:60 %, respectivamente. La calidad de la tortilla se midió con base en el diámetro (cm), espesor (mm), el peso de tortilla caliente y fría (g), la rolabilidad, el rendimiento de la tortilla caliente y fría y la colorimetría. Adicionalmente se realizó un análisis bromatológico a las tortillas. La evaluación sensorial se realizó mediante una prueba de aceptabilidad global y por atributos, usando escalas hedónicas. Se encontraron diferencias significativas entre las mezclas, para peso de la tortilla caliente y fría, rendimiento de tortilla fría y luminosidad. Las tortillas adicionadas con 40% de HAVN presentaron altos contenidos de proteína y fibra, pero menos aceptabilidad; mientras las de 10 y 20% presentaron mejor aceptabilidad, sabor, textura y contenido mayor de proteína comparado con las de HMN.

APA, Harvard, Vancouver, ISO, and other styles

26

Scarlino, Stefania, Teuta Domi, Laura Pozzi, Alessandro Romano, Giovanni Battista Pipitone, Yuri Matteo Falzone, Lorena Mosca, et al. "Burden of Rare Variants in ALS and Axonal Hereditary Neuropathy Genes Influence Survival in ALS: Insights from a Next Generation Sequencing Study of an Italian ALS Cohort." International Journal of Molecular Sciences 21, no. 9 (May 8, 2020): 3346. http://dx.doi.org/10.3390/ijms21093346.

Full text

Abstract:

Although the genetic architecture of amyotrophic lateral sclerosis (ALS) is incompletely understood, recent findings suggest a complex model of inheritance in ALS, which is consistent with a multistep pathogenetic process. Therefore, the aim of our work is to further explore the architecture of ALS using targeted next generation sequencing (NGS) analysis, enriched in motor neuron diseases (MND)-associated genes which are also implicated in axonal hereditary motor neuropathy (HMN), in order to investigate if disease expression, including the progression rate, could be influenced by the combination of multiple rare gene variants. We analyzed 29 genes in an Italian cohort of 83 patients with both familial and sporadic ALS. Overall, we detected 43 rare variants in 17 different genes and found that 43.4% of the ALS patients harbored a variant in at least one of the investigated genes. Of note, 27.9% of the variants were identified in other MND- and HMN-associated genes. Moreover, multiple gene variants were identified in 17% of the patients. The burden of rare variants is associated with reduced survival and with the time to reach King stage 4, i.e., the time to reach the need for percutaneous endoscopic gastrostomy (PEG) positioning or non-invasive mechanical ventilation (NIMV) initiation, independently of known negative prognostic factors. Our data contribute to a better understanding of the molecular basis of ALS supporting the hypothesis that rare variant burden could play a role in the multistep model of disease and could exert a negative prognostic effect. Moreover, we further extend the genetic landscape of ALS to other MND-associated genes traditionally implicated in degenerative diseases of peripheral axons, such as HMN and CMT2.

APA, Harvard, Vancouver, ISO, and other styles

27

José Calhorda, Maria, and Paulo J. Costa. "The H⋯H interaction in the solid state structure of HMn(CO)5." CrystEngComm 4, no. 64 (2002): 368–72. http://dx.doi.org/10.1039/b202430f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Xu, W., H. Li, T. Brodniewicz, F. A. Auger, and L. Germain. "Cultured epidermal sheet grafting with Hemaseel™ HMN fibrin sealant on nude mice." Burns 22, no. 3 (May 1996): 191–96. http://dx.doi.org/10.1016/0305-4179(95)00124-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

عبد المقصود, هدی. "قرص الشمس المجنح ودلالته فی مصر و الشرق الأدنی القدیم The Falcon God Hmn." Conference Book of the General Union of Arab Archeologists 15, no. 15 (November 1, 2012): 398–416. http://dx.doi.org/10.21608/cguaa.2012.33923.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Takashima, Hiroshi. "Clinical practice of hereditary motor neuropathy (HMN) and hereditary sensory and autonomic neuropathy (HSAN)." Rinsho Shinkeigaku 54, no. 12 (2014): 957–59. http://dx.doi.org/10.5692/clinicalneurol.54.957.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

TIMMERMAN, V., J. BEUTEN, J. IROBI, P. De JONGHE, J. J. MARTIN, and C. VAN BROECKHOVEN. "Distal Hereditary Motor Neuropathy Type II (Distal HMN Type II): Phenotype and Molecular Genetics." Annals of the New York Academy of Sciences 883, no. 1 (October 1999): 60–64. http://dx.doi.org/10.1111/j.1749-6632.1999.tb08568.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Hachey, Michel R. J., and Chantal Daniel. "The Spectroscopy of HMn(CO)5: A CASSCF/MRCI and CASPT2 ab Initio Study." Inorganic Chemistry 37, no. 6 (March 1998): 1387–91. http://dx.doi.org/10.1021/ic9707523.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Laine, Christopher M., Laura A. Nickerson, and E. Fiona Bailey. "Cortical entrainment of human hypoglossal motor unit activities." Journal of Neurophysiology 107, no. 1 (January 2012): 493–99. http://dx.doi.org/10.1152/jn.00769.2011.

Full text

Abstract:

Output from the primary motor cortex contains oscillations that can have frequency-specific effects on the firing of motoneurons (MNs). Whereas much is known about the effects of oscillatory cortical drive on the output of spinal MN pools, considerably less is known about the effects on cranial motor nuclei, which govern speech/oromotor control. Here, we investigated cortical input to one such motor pool, the hypoglossal motor nucleus (HMN), which controls muscles of the tongue. We recorded intramuscular genioglossus electromyogram (EMG) and scalp EEG from healthy adult subjects performing a tongue protrusion task. Cortical entrainment of HMN population activity was assessed by measuring coherence between EEG and multiunit EMG activity. In addition, cortical entrainment of individual MN firing activity was assessed by measuring phase locking between single motor unit (SMU) action potentials and EEG oscillations. We found that cortical entrainment of multiunit activity was detectable within the 15- to 40-Hz frequency range but was inconsistent across recordings. By comparison, cortical entrainment of SMU spike timing was reliable within the same frequency range. Furthermore, this effect was found to be intermittent over time. Our study represents an important step in understanding corticomuscular synchronization in the context of human oromotor control and is the first study to document SMU entrainment by cortical oscillations in vivo.

APA, Harvard, Vancouver, ISO, and other styles

34

Abusayeed, Mohamed H., Rasika G. V. Rampatige, S. L. Peiris, and H. Galappathi. "A Qualitative Assessment of the Health Information System in Sri Lanka using HMN assessment tool." Sri Lanka Journal of Bio-Medical Informatics 1, no. 2 (April 7, 2010): 90. http://dx.doi.org/10.4038/sljbmi.v1i2.1664.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Xie, X. "RIGIDITY OF QUASI-ISOMETRIES OF HMN ASSOCIATED WITH NON-DIAGONALIZABLE DERIVATION OF THE HEISENBERG ALGEBRA." Quarterly Journal of Mathematics 66, no. 1 (July 27, 2014): 353–67. http://dx.doi.org/10.1093/qmath/hau021.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Abu Zaid, Mohammad Issam, Michael T. Milano, Paul C. Dinh, Sophie Fosså, Hongmei Yang, Darren R. Feldman, Lois B. Travis, and Chunkit Fung. "Second solid (SMN) and hematologic malignant neoplasms (HMN) among 24,900 United States testicular cancer survivors (TCS) after chemotherapy (CHEM), radiotherapy (RT), or surgery only (SURG)." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 11573. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.11573.

Full text

Abstract:

11573 Background: No large, population-based U.S. study has comprehensively examined SMN and HMN risks after TC, taking into account initial therapy and focusing on recent decades. Methods: Standardized incidence ratios (SIR) for SMN and HMN stratified by site and time since TC diagnosis were calculated for 24,900 TCS (median age, TC diagnosis: 33 y) reported to population-based cancer registries in the NCI SEER program (1973-2014). TCS were initially given CHEM (n=6,340), RT (n=9,058), or SURG (n=8,995), with each group accruing 80,700, 156,735, and 128,039 person-years (PY) of follow-up, respectively. Results: During 372,709 PY of follow-up, 1,625 TCS developed SMN and 228 developed HMN, including 107 lymphomas, 92 leukemias, and 29 plasma cell dyscrasias. Among all TCS, overall risk of SMN was increased by 1.06-fold (95% CI 1.01-1.1). Risks of SMN were increased after RT (SIR 1.1, 95% CI 1.06-1.2) and CHEM (SIR 1.3, 95% CI 1.1-1.4); but not after SURG (SIR 0.8). After CHEM, significant excesses of SMN of the pancreas (SIR 2.2), soft tissue (SIR 4.0), kidney (SIR 1.7), thyroid (SIR 3.3) occurred; after RT, significantly elevated risks for SMN of the stomach (SIR 1.7), rectum/sigmoid (SIR 1.4), pancreas (SIR 2.7), soft tissue (SIR 2.2), bladder (SIR 1.5), and thyroid (SIR 2.0) were observed. The 30 year cumulative incidence of SMN after SURG, CHEM, and RT was 8.9% (95% CI 7.8-9.9), 10.1% (95% CI 8.8-11.5) and 17.0% (95% CI 15.8-18.2), respectively. Significantly increased risks of leukemia followed CHEM (SIR 2.7) and SURG (SIR 1.8) and were driven by increased risks for acute myeloid leukemia, with significant excesses restricted to 1-10 y and 1-5 y after TC diagnosis, respectively; nonsignificant 2-fold excesses occurred 1-10 y after RT. Risks for lymphoma and plasma cell dyscrasias were not elevated (1.02 and 1.27, respectively). Conclusions: In the largest population-based study of U.S. TCS to date, we report significant 6% excesses of SMN and 2-fold increased risks of leukemias. Efforts to minimize CHEM exposure and decrease doses/field size of RT in TC should continue. TCS should be educated about cancer prevention and screening.

APA, Harvard, Vancouver, ISO, and other styles

37

Lestari, Endah Sri, Sutopo Patria Jati, and Aris Puji Widodo. "Evaluasi Sistem Informasi Kesehatan di Provinsi Jawa Tengah Dalam Rangka Penguatan Sistem Informasi Kesehatan Nasional." Jurnal Manajemen Kesehatan Indonesia 4, no. 3 (December 1, 2016): 222–31. http://dx.doi.org/10.14710/jmki.4.3.2016.222-231.

Full text

Abstract:

Evaluasi SIK bertujuan untuk memastikan SIK berjalan secara efisien, mampu mengumpulkan informasi yang relevan dan berkualitas sebagai dasar pengambilan keputusan oleh pemangku kebijakan. Hasil penilaian SIK sangat dibutuhkan dalam meningkatkan kinerja SIK.SIK Provinsi Jawa Tengah merupakan sub sistem dari SIKNAS sehingga pengembangan SIK Provinsi Jawa Tengah akan berpengaruh terhadap penguatan SIKNAS. Tujuan dari penelitian ini adalah untuk mengevaluasi SIK di Provinsi Jawa Tengah dalam rangka Penguatan SIKNAS. Penelitian ini merupakan penelitian deskriptif evaluatif dengan pendekatan kuantitatif dan kualitatif. Subyek penelitian adalah 35 petugas SIK DKK dan enam petugas SIK Dinas Kesehatan Provinsi Jawa Tengah. Pengumpulan data kuantitatif melalui pengisian kuesioner, pengumpulan data kualitatif melalui FGD dan wawancara. Analisis data penelitian dilakukan dengan menggunakan perangkat Evaluasi SIK Provinsi yang merupakan modifikasi dari Assessment Tool HMN Versi 4.00. Modifikasi Assessment Tool HMN Versi 4.00 dilakukan dengan cara menghapus item pertanyaan yang tidak relevan dengan SIK di provinsi dan menambahkan item pertanyaan berdasarkan PP no 46/2016 tentang SIK. Hasil evaluasi terhadap tujuh komponen SIK, empat diantaranya dinilai “ada tapi tidak adekuat” yaitu komponen pengelolaan (54,7%), sumber daya (54,2%), sumber data (58%) dan manajemen data (41,3%). Sementara tiga komponen lainnya dinilai “adekuat”, yaitu komponen indikator (74,3%), produk informasi (71,3%) dan diseminasi dan penggunaan informasi (74,5%).Disimpulkan bahwa secara umum SIK Provinsi Jawa Tengah berada dalam kategori “adekuat”. Untuk meningkatkan pengelolaan SIK di Provinsi Jawa Tengah, direkomendasikan untuk membuat suatu standar tata kelola SIK sebagai acuan pengelolaan SIK di Provinsi Jawa Tengah. Evaluation of Health Information System (HIS) aimed at ascertaining the efficient implementation of HIS that could result relevant and high-quality information to be used as a basis of making a decision by a decision maker. The result of HIS assessment was needed to improve the HIS performance. HIS of Central Java Province was a sub-system of National Health Information System (NHIS) in which the development of HIS there would strengthen the NHIS. The aim of this study was to evaluate HIS in Central Java Province in order to strengthen NHIS. This was a descriptive-evaluative study using quantitative-qualitative approach. Research subjects were 35 HIS officers at District Health Office (DHO) and six HIS officers at Central Java Province Health Office. Quantitative data were collected by filling a questionnaire whereas qualitative data were collected by conducting FGD and indepth interview. Data analysis was performed using a software of Province HIS evaluation that was modified from Assessment Tool HMN version 4.00. Modification of Assessment Tool HMN version 4.00 was performed by deleting questions that were irrelevant with HIS at province and adding questions based on government regulation number 46/2016 about HIS. The results of evaluation of seven components of HIS, four of these seven components indicated “available but inadequate”, namely components of management (54.7%), resource (54.2%), data source (58%), and data management (41.3%). In contrast, three of these seven components were “adequate”, namely components of indicator (74.3%), information product (71.3%), and dissemination and use of information (74.5%). To sum up, generally HIS of Central Java Province was categorised as “adequate”. To improve HIS management in Central Java Province, a standard of HIS management needs to be made as a reference to manage HIS in Central Java Province.

APA, Harvard, Vancouver, ISO, and other styles

38

Timmerman, V. "Distal hereditary motor neuropathy type II (distal HMN II): mapping of a locus to chromosome 12q24." Human Molecular Genetics 5, no. 7 (July 1, 1996): 1065–69. http://dx.doi.org/10.1093/hmg/5.7.1065.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Sharma, Vandana, Kirti Yadav, P. C. Choyal, and V. R. Chourey. "Kinetic Evaluation of Influence of Surfactant on Oxidation Reaction of Carboxylic Acid by Molecular Hmn O4." Oriental Journal of Chemistry 33, no. 6 (December 25, 2017): 3177–84. http://dx.doi.org/10.13005/ojc/330662.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Houlden, H., M. Laura, F. Wavrant-De Vrieze, J. Blake, N. Wood, and M. M. Reilly. "Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2." Neurology 71, no. 21 (October 1, 2008): 1660–68. http://dx.doi.org/10.1212/01.wnl.0000319696.14225.67.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Timmerman, Vincent, Peter Raeymaekers, Eva Nelis, Peter De Jonghe, Ludo Muylle, Chantal Ceuterick, Jean-Jacques Martin, and Christine Van Broeckhoven. "Linkage analysis of distal hereditary motor neuropathy type II (distal HMN II) in a single pedigree." Journal of the Neurological Sciences 109, no. 1 (May 1992): 41–48. http://dx.doi.org/10.1016/0022-510x(92)90091-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Allen, Christopher C. R., Derek R. Boyd, Francis Hempenstall, Michael J. Larkin, and Narain D. Sharma. "Contrasting Effects of a Nonionic Surfactant on the Biotransformation of Polycyclic Aromatic Hydrocarbons tocis-Dihydrodiols by Soil Bacteria." Applied and Environmental Microbiology 65, no. 3 (March 1, 1999): 1335–39. http://dx.doi.org/10.1128/aem.65.3.1335-1339.1999.

Full text

Abstract:

ABSTRACT The biotransformation of the polycyclic aromatic hydrocarbons (PAHs) naphthalene and phenanthrene was investigated by using two dioxygenase-expressing bacteria, Pseudomonas sp. strain 9816/11 and Sphingomonas yanoikuyae B8/36, under conditions which facilitate mass-transfer limited substrate oxidation. Both of these strains are mutants that accumulate cis-dihydrodiol metabolites under the reaction conditions used. The effects of the nonpolar solvent 2,2,4,4,6,8,8-heptamethylnonane (HMN) and the nonionic surfactant Triton X-100 on the rate of accumulation of these metabolites were determined. HMN increased the rate of accumulation of metabolites for both microorganisms, with both substrates. The enhancement effect was most noticeable with phenanthrene, which has a lower aqueous solubility than naphthalene. Triton X-100 increased the rate of oxidation of the PAHs with strain 9816/11 with the effect being most noticeable when phenanthrene was used as a substrate. However, the surfactant inhibited the biotransformation of both naphthalene and phenanthrene with strain B8/36 under the same conditions. The observation that a nonionic surfactant could have such contrasting effects on PAH oxidation by different bacteria, which are known to be important for the degradation of these compounds in the environment, may explain why previous research on the application of the surfactants to PAH bioremediation has yielded inconclusive results. The surfactant inhibited growth of the wild-type strain S. yanoikuyae B1 on aromatic compounds but did not inhibit B8/36 dioxygenase enzyme activity in vitro.

APA, Harvard, Vancouver, ISO, and other styles

43

Hamada, Koki, Dai Ikarashi, Ryo Kikuchi, and Koji Chida. "Efficient decision tree training with new data structure for secure multi-party computation." Proceedings on Privacy Enhancing Technologies 2023, no. 1 (January 2023): 343–64. http://dx.doi.org/10.56553/popets-2023-0021.

Full text

Abstract:

We propose a secure multi-party computation (MPC) protocol that constructs a secret-shared decision tree for a given secret-shared dataset. The previous MPC-based decision tree training protocol (Abspoel et al. 2021) requires $O(2^hmn log n)$ comparisons, being exponential in the tree height $h$ and with $n$ and $m$ being the number of rows and that of attributes in the dataset, respectively. The cause of the exponential number of comparisons in $h$ is that the decision tree training algorithm is based on the divide-and-conquer paradigm, where rows are padded after each split in order to hide the number of rows in the dataset. We resolve this issue via secure data structure that enables us to compute an aggregate value for every group while hiding the grouping information. By using this data structure, we can train a decision tree without padding to rows while hiding the size of the intermediate data. We specifically describes a decision tree training protocol that requires only $O(hmn log n)$ comparisons when the input attributes are continuous and the output attribute is binary. Note that the order is now linear in the tree height $h$. To demonstrate the practicality of our protocol, we implement it in an MPC framework based on a three-party secret sharing scheme. Our implementation results show that our protocol trains a decision tree with a height of 4 in 404 seconds for a dataset of $2^{20}$ rows and 11 attributes.

APA, Harvard, Vancouver, ISO, and other styles

44

Putra, Supriadi, M. Imran, Ayunda Putri, and Rike Marjulisa. "Dynamic Comparison of Variations of Newton’s Methods with Different Types of Means for Solving Nonlinear Equations." International Journal of Mathematics And Computer Research 10, no. 11 (November 30, 2022): 2969–74. http://dx.doi.org/10.47191/ijmcr/v10i11.04.

Full text

Abstract:

This article discusses dynamic comparison of variations of Newton’s methods with different types of means for solving nonlinear equations. There are two factors that are considered to affect the shape of the basin of attraction of a method namely the size of the determined convergence area and number of partitions. The computation results of some functions show that harmonic mean Newton’s method (HMN) has small divergence area. On the other hand, contra harmonic mean Newton’s method (CMN) has the largest divergence area and is considered to be the least effective method

APA, Harvard, Vancouver, ISO, and other styles

45

Brandes, Ivo F., Edward J. Zuperku, Astrid G. Stucke, Francis A. Hopp, Danica Jakovcevic, and Eckehard A. E. Stuth. "Isoflurane Depresses the Response of Inspiratory Hypoglossal Motoneurons to Serotonin In Vivo." Anesthesiology 106, no. 4 (April 1, 2007): 736–45. http://dx.doi.org/10.1097/01.anes.0000264750.93769.99.

Full text

Abstract:

Background Endogenous serotonin (5-HT) provides important excitatory drive to inspiratory hypoglossal motoneurons (IHMNs). In vitro studies show that activation of postsynaptic 5-HT receptors decreases a leak K+ channel conductance and depolarizes hypoglossal motoneurons (HMNs). In contrast, volatile anesthetics increase this leak K+ channel conductance, which causes neuronal membrane hyperpolarization and depresses HMN excitability. Clinical studies show upper airway obstruction, indicating HMN depression, even at subanesthetic concentrations. The authors hypothesized that if anesthetic activation of leak K+ channels caused neuronal depression in vivo, this effect could be antagonized with serotonin. In this case, the neuronal response to picoejected serotonin would be greater during isoflurane than with no isoflurane. Methods Studies were performed in decerebrate, vagotomized, paralyzed, and mechanically ventilated dogs during hypercapnic hyperoxia. The authors studied the effect of approximately 0.3 minimum alveolar concentration (MAC) isoflurane on the spontaneous discharge frequency patterns of single IHMNs and on the neuronal response to picoejection of 5-HT. Results Normalized data (mean +/- SD, n = 19) confirmed that 0.3 +/- 0.1 MAC isoflurane markedly reduced the spontaneous peak discharge frequency by 48 +/- 19% (P < 0.001) and depressed the slope of the spontaneous discharge patterns. The increase in neuronal frequency in response to 5-HT was reduced by 34 +/- 22% by isoflurane (P < 0.001). Conclusion Subanesthetic concentrations of isoflurane strongly depressed canine IHMNs in vivo. The neuronal response to 5-HT was also depressed by isoflurane, suggesting that anesthetic activation of leak K+ channels, which is expected to result in a larger 5-HT response, was not a dominant mechanism in this depression.

APA, Harvard, Vancouver, ISO, and other styles

46

Forster, Hubert V. "Julius H. Comroe Distinguished Lecture: Interdependence of neuromodulators in the control of breathing." Journal of Applied Physiology 125, no. 5 (November 1, 2018): 1511–25. http://dx.doi.org/10.1152/japplphysiol.00477.2018.

Full text

Abstract:

In vitro and in vivo anesthetized studies led to the conclusion that “deficiencies in one neuromodulator are immediately compensated by the action of other neuromodulators,” which suggests an interdependence among neuromodulators. This concept was the focus of the 2018 Julius H. Comroe Lecture to the American Physiological Society in which I summarized our published studies testing the hypothesis that if modulatory interdependence was robust, breathing would not decrease during dialysis of antagonists to G protein-coupled excitatory receptors or agonists to inhibitory receptors into the ventral respiratory column (VRC) or the hypoglossal motor nuclei (HMN). We found breathing was not decreased during unilateral VRC dialyses of antagonists to excitatory muscarinic, serotonergic, and neurokinin-1 receptors alone or in combinations nor was breathing decreased with unilateral VRC dialysis of a µ-opioid receptor agonist. Analyses of the effluent dialysate revealed locally increased serotonin (excitatory) during muscarinic receptor blockade and decreased γ-aminobutyric acid (inhibitory) during dialysis of opioid agonists, suggesting an interdependence of neuromodulators through release of compensatory neuromodulators. Bilateral dialysis of receptor antagonists or agonist in the VRC increased breathing, which does not support the concept that unchanged breathing with unilateral dialyses was due to contralateral compensation. In contrast, in the HMN neither unilateral nor bilateral dialysis of the excitatory receptor antagonists altered breathing, but unilateral dialysis of the opioid receptor agonist decreased breathing. We conclude: 1) there is site-dependent interdependence of neuromodulators during physiologic conditions, and 2) attributing physiologic effects to a specific receptor perturbation is complicated by local compensatory mechanisms.

APA, Harvard, Vancouver, ISO, and other styles

47

Leung, S., M. J. Losman, S. V. Govindan, G. L. Griffiths, D. M. Goldenberg, and H. J. Hansen. "Engineering a unique glycosylation site for site-specific conjugation of haptens to antibody fragments." Journal of Immunology 154, no. 11 (June 1, 1995): 5919–26. http://dx.doi.org/10.4049/jimmunol.154.11.5919.

Full text

Abstract:

Abstract A natural N-linked glycosylation site (Asn-Val-Thr) at amino acid positions 18-20 (Kabat's numbering) was identified in the framework-1 (FR-1) region of the light chain variable (V kappa) domain of a murine anti-B cell lymphoma Ab, LL-2. Our earlier studies demonstrated that no contact between the V kappa-appended oligosaccharide and the Ag binding site was evident, because glycosylation at this site did not affect the Ag binding property of the Ab. By using the murine LL-2 F(ab')2 fragment (which is devoid of constant region-appended oligosaccharide) as substrate, as much as five bifunctional chelator molecules per F(ab')2 fragment could be site specifically conjugated at the V kappa-appended carbohydrate moiety with no reduction in immunoreactivity. The resulting conjugates labeled efficiently with both 90Y and 111In, with no significant effect on Ab affinity. In contrast, conjugation of less than five chelates/Ab fragment randomly at lysine residues resulted in a three- to fivefold reduction in affinity. By a single Arg to Asn mutation, an N-linked glycosylation site similar to that of LL-2 was introduced in the FR-1 segment of a nonglycosylated, humanized anti-carcinoembryonic Ag (CEA) Ab, MN-14 (hMN-14). Glycosylation at the engineered carbohydrate-addition site was demonstrated by SDS-PAGE analysis. Neither glycosylation nor site-specific conjugation of chelate at the V kappa-appended carbohydrate moiety resulted in the loss of immunoreactivity. The glycosylated hMN-14 conjugate labeled efficiently with 90Y.

APA, Harvard, Vancouver, ISO, and other styles

48

Cierniewski, Czeslaw S., Elzbieta Pluskota, Marcin Cieslak, Teresa Brodniewicz, and Margaret Nowotarski. "Antigenic properties of fibrinogen component of hemaseel™ HMN subjected to the antiviral severe dry heat treatment." Thrombosis Research 82, no. 4 (May 1996): 349–59. http://dx.doi.org/10.1016/0049-3848(96)00084-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

McBlain, B. A., R. J. Fioritto, A. F. Schmitthenner, S. J. Carson, and A. K. Walker. "Registration of HM2, HM3, and HM4 Phytophtora Resistant Soybean Germplasm." Crop Science 33, no. 1 (January 1993): 217. http://dx.doi.org/10.2135/cropsci1993.0011183x003300010063x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Mondal, Sourav, Nilanjan De, and Anita Pal. "Onsome New Neighbourhood Degree Based Indices." Acta Chemica Iasi 27, no. 1 (June 1, 2019): 31–46. http://dx.doi.org/10.2478/achi-2019-0003.

Full text

Abstract:

Abstract In this paper, four novel topological indices named as neighbourhood version of forgotten topological index (FN), modified neighbourhood version of Forgotten topological index (FN*), neighbourhood version of second Zagreb index (M2*) and neighbourhood version of hyper Zagreb index (HMN) are introduced. Here the relatively study depends on the structure-property regression analysis is made to test and compute the chemical applicability of these indices for the prediction of physicochemical properties of octane isomers. Also it is shown that these newly presented indices have well degeneracy property in comparison with other degree based topological indices. Some mathematical properties of these indices are also discussed here.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!