Relevant bibliographies by topics / HMATE1

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'HMATE1'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 February 2022

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Journal articles on the topic "HMATE1"

1

Ohta, Kin-ya, Katsuhisa Inoue, Tomoya Yasujima, Munenori Ishimaru, and Hiroaki Yuasa. "Functional Characteristics of Two Human MATE Transporters: Kinetics of Cimetidine Transport and Profiles of Iinhibition by Various Compounds." Journal of Pharmacy & Pharmaceutical Sciences 12, no. 3 (January 6, 2010): 388. http://dx.doi.org/10.18433/j3r59x.

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Purpose. Human multidrug and toxin extrusion protein 1 (hMATE1) and hMATE2-K are organic cation/H+ antiporters that have recently been identified and suggested to be involved in the renal brush border secretion of various organic cations. Information about functional characteristics of them has been accumulating, but still insufficient to fully understand their functions and respective roles. The present study was conducted to help clarify them. Methods. The cDNA of hMATE1 was isolated from human brain cDNA by RT-PCR and hMATE2-K cDNA was from human kidney cDNA. HEK293 cells were stably transfected with hMATE1 and hMATE2-K, and the cellular uptakes of [3H]cimetidine and [14C]tetraethylammonium (TEA) were evaluated. Results. It was first found that both hMATE1 and hMATE2-K can transport cimetidine with high affinities, indicated by small Michaelis constants of 8.00 mM and 18.18 mM, respectively. These were much smaller than those for TEA (366 mM and 375 mM, respectively, for hMATE1 and hMATE2-K). Subsequent investigation using cimetidine as a probe substrate into the profiles of inhibition of the two hMATEs by various compounds indicated that they are similar in principle but different to some extent in substrate recognition, reflecting the modest differences in amino acid sequences between them. In fact, cimetidine transport by hMATE1 was correlated to that by hMATE2-K, which is 65% similar to hMATE1, but not as good as to that by rat MATE1, which is 86% similar. Conclusions. Cimetidine was demonstrated to be a high affinity substrate of both hMATEs. Subsequent evaluation of the inhibition of hMATEs by various compounds indicated no major difference in function or role between hMATE1 and hMATE2-K.
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Kantauskaitė, Marta, Anna Hucke, Moritz Reike, Sara Ahmed Eltayeb, Chuyan Xiao, Vivien Barz, and Giuliano Ciarimboli. "Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K." International Journal of Molecular Sciences 21, no. 14 (July 21, 2020): 5157. http://dx.doi.org/10.3390/ijms21145157.

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Vectorial transport of organic cations (OCs) in renal proximal tubules is mediated by sequential action of human OC transporter 2 (hOCT2) and human multidrug and toxic extrusion protein 1 and 2K (hMATE1 and hMATE2K), expressed in the basolateral (hOCT2) and luminal (hMATE1 and hMATE2K) plasma membranes, respectively. It is well known that hOCT2 activity is subjected to rapid regulation by several signaling pathways, suggesting that renal OC secretion may be acutely adapted to physiological requirements. Therefore, in this work, the acute regulation of hMATEs stably expressed in human embryonic kidney cells was characterized using the fluorescent substrate 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP+) as a marker. A specific regulation of ASP+ transport by hMATE1 and hMATE2K measured in uptake and efflux configurations was observed. In the example of hMATE1 efflux reduction by inhibition of casein kinase II, it was also shown that this regulation is able to modify transcellular transport of ASP+ in Madin–Darby canine kidney II cells expressing hOCT2 and hMATE1 on the basolateral and apical membrane domains, respectively. The activity of hMATEs can be rapidly regulated by some intracellular pathways, which sometimes are common to those found for hOCTs. Interference with these pathways may be important to regulate renal secretion of OCs.
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Dangprapai, Yodying, and Stephen H. Wright. "Interaction of H+ with the extracellular and intracellular aspects of hMATE1." American Journal of Physiology-Renal Physiology 301, no. 3 (September 2011): F520—F528. http://dx.doi.org/10.1152/ajprenal.00075.2011.

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Human multidrug and toxin extrusion 1 (hMATE1, SLC47A1) is a major candidate for being the molecular identity of organic cation/proton (OC/H+) exchange activity in the luminal membrane of renal proximal tubules. Although physiological function of hMATE1 supports luminal OC efflux, the kinetics of hMATE1-mediated OC transport have typically been characterized through measurement of uptake, i.e., the interaction between outward-facing hMATE1 and OCs. To examine kinetics of hMATE1-mediated transport in a more physiologically relevant direction, i.e., an interaction between inward-facing hMATE1 and cytoplasmic substrates, we measured the time course of hMATE1-mediated efflux of the prototypic MATE1 substrate, [3H]1-methyl-4-phenylpyridinium, under a variety of intra- and extracellular pH conditions, from Chinese hamster ovary cells that stably expressed the transporter. In this study, we showed that an IC50/ Ki for interaction between extracellular H+ and outward-facing hMATE1 determined from conventional uptake experiments [12.9 ± 1.23 nM (pH 7.89); n = 9] and from the efflux protocol [14.7 ± 3.45 nM (pH 7.83); n = 3] was not significantly different ( P = 0.6). Furthermore, kinetics of interaction between intracellular H+ and inward-facing hMATE1 determined using the efflux protocol revealed an IC50 for H+ of 11.5 nM (pH 7.91), consistent with symmetrical interactions of H+ with the inward-facing and outward-facing aspects of hMATE1.
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Yin, Jia, David J. Wagner, Bhagwat Prasad, Nina Isoherranen, Kenneth E. Thummel, and Joanne Wang. "Renal secretion of hydrochlorothiazide involves organic anion transporter 1/3, organic cation transporter 2, and multidrug and toxin extrusion protein 2-K." American Journal of Physiology-Renal Physiology 317, no. 4 (October 1, 2019): F805—F814. http://dx.doi.org/10.1152/ajprenal.00141.2019.

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Hydrochlorothiazide (HCTZ) is the most widely used thiazide diuretic for the treatment of hypertension either alone or in combination with other antihypertensives. HCTZ is mainly cleared by the kidney via tubular secretion, but the underlying molecular mechanisms are unclear. Using cells stably expressing major renal organic anion and cation transporters [human organic anion transporter 1 (hOAT1), human organic anion transporter 3 (hOAT3), human organic cation transporter 2 (hOCT2), human multidrug and toxin extrusion 1 (hMATE1), and human multidrug and toxin extrusion 2-K (hMATE2-K)], we found that HCTZ interacted with both organic cation and anion transporters. Uptake experiments further showed that HCTZ is transported by hOAT1, hOAT3, hOCT2, and hMATE2-K but not by hMATE1. Detailed kinetic analysis coupled with quantification of membrane transporter proteins by targeted proteomics revealed that HCTZ is an excellent substrate for hOAT1 and hOAT3. The apparent affinities ( Km) for hOAT1 and hOAT3 were 112 ± 8 and 134 ± 13 μM, respectively, and the calculated turnover numbers ( kcat) were 2.48 and 0.79 s−1, respectively. On the other hand, hOCT2 and hMATE2-K showed much lower affinity for HCTZ. The calculated transport efficiency ( kcat/ Km) at the single transporter level followed the rank order of hOAT1> hOAT3 > hOCT2 and hMATE2-K, suggesting a major role of organic anion transporters in tubular secretion of HCTZ. In vitro inhibition experiments further suggested that HCTZ is not a clinically relevant inhibitor for hOAT1 or hOAT3. However, strong in vivo inhibitors of hOAT1/3 may alter renal secretion of HCTZ. Together, our study elucidated the molecular mechanisms underlying renal handling of HCTZ and revealed potential pathways involved in the disposition and drug-drug interactions for this important antihypertensive drug in the kidney.
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Yang, Xi, Zhiyuan Ma, Sisi Zhou, Yayun Weng, Hongmei Lei, Su Zeng, Liping Li, and Huidi Jiang. "Multiple Drug Transporters Are Involved in Renal Secretion of Entecavir." Antimicrobial Agents and Chemotherapy 60, no. 10 (August 8, 2016): 6260–70. http://dx.doi.org/10.1128/aac.00986-16.

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ABSTRACTEntecavir (ETV) is a first-line antiviral agent for the treatment of chronic hepatitis B virus infection. Renal excretion is the major elimination path of ETV, in which tubular secretion plays the key role. However, the secretion mechanism has not been clarified. We speculated that renal transporters mediated the secretion of ETV. Therefore, the aim of our study was to elucidate which transporters contribute to the renal disposition of ETV. Our results revealed that ETV (50 μM) remarkably reduced the accumulation of probe substrates in MDCK cells stably expressing human multidrug and toxin efflux extrusion proteins (hMATE1/2-K), organic cation transporter 2 (hOCT2), and carnitine/organic cation transporters (hOCTNs) and increased the substrate accumulation in cells transfected with multidrug resistance-associated protein 2 (hMRP2) or multidrug resistance protein 1 (hMDR1). Moreover, ETV was proved to be a substrate of the above-described transporters. In transwell studies, the transport of ETV in MDCK-hOCT2-hMATE1 showed a distinct directionality from BL (hOCT2) to AP (hMATE1), and the cellular accumulation of ETV in cells expressing hMATE1 was dramatically lower than that of the mock-treated cells. The accumulation of ETV in mouse primary renal tubular cells was obviously affected by inhibitors of organic anion transporter 1/3 (Oat1/3), Oct2, Octn1/2, and Mrp2. Therefore, the renal uptake of ETV is likely mediated by OAT1/3 and OCT2 while the efflux is mediated by MATEs, MDR1, and MRP2, and OCTN1/2 may participate in both renal secretion and reabsorption.
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Kajiwara, Moto, Tomohiro Terada, Jun-ichi Asaka, Ken Ogasawara, Toshiya Katsura, Osamu Ogawa, Atsushi Fukatsu, Toshio Doi, and Ken-ichi Inui. "Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1." American Journal of Physiology-Renal Physiology 293, no. 5 (November 2007): F1564—F1570. http://dx.doi.org/10.1152/ajprenal.00322.2007.

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A H+/organic cation antiporter (multidrug and toxin extrusion 1: MATE1/SLC47A1) plays important roles in the tubular secretion of various clinically important cationic drugs such as cimetidine. We have recently found that the regulation of this transporter greatly affects the pharmacokinetic properties of cationic drugs in vivo. No information is available about the regulatory mechanisms for the MATE1 gene. In the present study, therefore, we examined the gene regulation of human (h) and rat (r) MATE1, focusing on basal expression. A deletion analysis suggested that the regions spanning −65/−25 and −146/−38 were essential for the basal transcriptional activity of the hMATE1 and rMATE1 promoter, respectively, and that both regions contained putative Sp1-binding sites. Functional involvement of Sp1 was confirmed by Sp1 overexpression, a mutational analysis of Sp1-binding sites, mithramycin A treatment, and an electrophoretic mobility shift assay. Furthermore, we found a single nucleotide polymorphism (SNP) in the promoter region of hMATE1 (G−32A), which belongs to a Sp1-binding site. The allelic frequency of this rSNP was 3.7%, and Sp1-binding and promoter activity were significantly decreased. This is the first study to clarify the transcriptional mechanisms of the MATE1 gene and to identify a SNP affecting the promoter activity of hMATE1.
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Sato, Tomoko, Satohiro Masuda, Atsushi Yonezawa, Yuko Tanihara, Toshiya Katsura, and Ken-ichi Inui. "Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1." Biochemical Pharmacology 76, no. 7 (October 2008): 894–903. http://dx.doi.org/10.1016/j.bcp.2008.07.005.

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zhang, xiaohong, and Stephen H. Wright. "Determination of hMATE1 Turnover Rate Using Quantitative Western Analysis." FASEB Journal 34, S1 (April 2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.09360.

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Yang, Hong, Shiwei Zhou, Dong Guo, Obinna N. Obianom, Qing Li, and Yan Shu. "Divergent Regulation of OCT and MATE Drug Transporters by Cadmium Exposure." Pharmaceutics 13, no. 4 (April 13, 2021): 537. http://dx.doi.org/10.3390/pharmaceutics13040537.

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Coordinated transcellular transport by the uptake via organic cation transporters (OCTs) in concert with the efflux via multidrug and toxin extrusion proteins (MATEs) is an essential system for hepatic and renal drug disposition. Despite their clinical importance, the regulation of OCTs and MATEs remains poorly characterized. It has been reported that cadmium (Cd2+) increase the activities of OCTs while being a substrate of MATEs. Here, we found that human (h) OCT2 protein, as compared with hMATE1, was more active in trafficking between the plasma membrane and cytoplasmic storage pool. Cd2+ exposure could significantly enhance the translocation of hOCT2 and hOCT1, but not hMATE1, to the plasma membrane. We further identified that candesartan, a widely prescribed angiotensin II receptor blocker, behaved similarly toward OCT2 and MATE1 as Cd2+ did. Importantly, Cd2+ and candesartan treatments could lead to an enhanced accumulation of metformin, which is a well-characterized substrate of OCTs/MATEs, in mouse kidney and liver, respectively. Altogether, our studies have uncovered possible divergent regulation of OCTs and MATEs by certain xenobiotics, such as Cd2+ and candesartan due to the different cellular trafficking of these two families of transporter proteins, which might significantly affect drug disposition in the liver and kidney.
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Matsumoto, Takuya, Takuji Kanamoto, Masato Otsuka, Hiroshi Omote, and Yoshinori Moriyama. "Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter." American Journal of Physiology-Cell Physiology 294, no. 4 (April 2008): C1074—C1078. http://dx.doi.org/10.1152/ajpcell.00504.2007.

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Human multidrug and toxic compound extrusion 1 (hMATE1) is an electroneutral H+/organic cation exchanger responsible for the final excretion step of structurally unrelated toxic organic cations in kidney and liver. To elucidate the molecular basis of the substrate recognition by hMATE1, we substituted the glutamate residues Glu273, Glu278, Glu300, and Glu389, which are conserved in the transmembrane regions, for alanine or aspartate and examined the transport activities of the resulting mutant proteins using tetraethylammonium (TEA) and cimetidine as substrates after expression in human embryonic kidney 293 (HEK-293) cells. All of these mutants except Glu273Ala were fully expressed and present in the plasma membrane of the HEK-293 cells. TEA transport activity in the mutant Glu278Ala was completely absent. Both Glu300Ala and Glu389Ala and all aspartate mutants exhibited significantly decreased activity. Glu273Asp showed higher affinity for cimetidine, whereas it has reduced affinity to TEA. Glu278Asp showed decreased affinity to cimetidine. Both Glu300Asp and Glu389Asp had lowered affinity to TEA, whereas the affinity of Glu389Asp to cimetidine was fourfold higher than that of the wild-type transporter with about a fourfold decrease in Vmax value. Both Glu273Asp and Glu300Asp had altered pH dependence for TEA uptake. These results suggest that all of these glutamate residues are involved in binding and/or transport of TEA and cimetidine but that their individual roles are different.
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Dissertations / Theses on the topic "HMATE1"

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Dangprapai, Yodying. "Human Multidrug and Toxin Extrusion Protein 1: Symmetry of substrate fluxes." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/145435.

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Human multidrug and toxin extrusion 1 (hMATE1) is a major candidate for being the molecular identity of organic cation/proton (OC/H+) exchange activity in the luminal membrane of renal proximal tubules (RPT). Although physiological function of hMATE1 supports luminal OC efflux, the kinetics of hMATE1-mediated OC transport have typically been characterized through measurement of uptake i.e., the interaction between outward-facing hMATE1 and OCs. To examine kinetics of hMATE1-mediated transport in a more physiologically relevant direction i.e., an interaction between inward-facing hMATE1 and cytoplasmic substrates, I measured the time course of hMATE1-mediated efflux of the prototypic MATE1-substrate, [3H]1-methyl-4-phenylpyridinium ([3H]MPP), under a variety of conditions, including different values for intra- and extracellular pH, from CHO cells that stably expressed hMATE1. I showed that an IC50/Ki for interaction between extracellular H+ and outward-facing hMATE1 determined from conventional uptake experiments [12.9 ± 1.23 nM (pH 7.89); n = 9] and from the efflux protocol [14.7 ± 3.45 nM (pH 7.83); n = 3] were not significantly different (P = 0.6). To test a hypothesis that H+ interacts symmetrically with each face of hMATE1, kinetics of interaction between intracellular H+ and inward-facing hMATE1 were determined using the efflux protocol. The IC50 for interaction with H+ was 11.5 nM (pH 7.91), consistent with symmetrical interactions of H+ with the inward-facing and outward-facing aspects of hMATE1. The efflux protocols demonstrated in this study are a potential means to examine kinetics at cytoplasmic face of hMATE1 and also a practical tool to screen uptake of substrates at extracellular face of hMATE1.
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Avalos, Ana M. "HMA1 and HMA6 are essential components of metal homeostasis in Arabidopsis thaliana." Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-0429104-112415.

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Boutigny, Sylvain. "Quelques observations sur le rôle des ATPases à cuivre HMA1 et PAA1 dans le contrôle de l'homéostasie du cuivre chloroplastique." Phd thesis, Université Joseph Fourier (Grenoble), 2009. http://tel.archives-ouvertes.fr/tel-00538124.

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Le chloroplaste est un organite spécifique de la cellule végétale. Il est délimité par une double membrane ou enveloppe qui renferme de nombreux systèmes de transports d'ions et de métabolites essentiels au fonctionnement du chloroplaste et de la cellule végétale. A ce jour, seuls quelques transporteurs de métaux associés à l'enveloppe des plastes ont été identifiés : un transporteur de fer, un transporteur de magnésium ainsi que deux ATPases à cuivre de type P1B : HMA1 et PAA1. PAA1 représenterait la voie principale d'import du cuivre dans le chloroplaste, notamment pour alimenter la photosynthèse. HMA1 constituerait une voie additionnelle d'import du cuivre, voie essentielle pour répondre à un stress oxydatif qui apparaît en particulier lorsque la plante est cultivée en lumière forte. Afin de mieux comprendre les rôles respectifs de ces deux ATPases dans la régulation de l'homéostasie du cuivre chloroplastique, deux approches complémentaires ont été développées : - une approche in planta visant à produire de nouvelles lignées affectées dans l'expression de l'une (mutant paa1 surexprimant HMA1) ou de ces deux ATPases (double mutant hma1/paa1), puis à identifier des conditions (stress lumineux, stress salin, excès de métaux) révélant le rôle essentiel de ces ATPases ou induisant une réponse transcriptionnelle différente des gènes codant ces ATPases ou d'autres acteurs liés à l'homéostasie du cuivre... Les résultats obtenus montrent que la fonction de HMA1, connue pour être essentielle lors d'un stress lumineux, est aussi requise lorsque la plante subit un stress salin. Ces résultats confortent le rôle de HMA1 dans la délivrance du cuivre à la superoxyde dismutase (cuivre/zinc) du chloroplaste. D'autre part, nous avons montré qu'en condition de culture photoautotrophe, le cuivre permet de supprimer partiellement la photosensibilité du mutant hma1, validant ainsi l'implication de HMA1 dans l'homéostasie du cuivre. Nous avons aussi démontré que les fonctions de HMA1 et PAA1 ne sont pas redondantes. Le cuivre importé par ces deux ATPases est probablement délivré à des protéines cibles par des voies différentes. Enfin, nous avons montré qu'il existe une troisième voie d'import de cuivre dans le chloroplaste, voie encore non caractérisée. - une approche in vitro visant à produire ces deux ATPases HMA1 et PAA1 dans le système hétérologue Lactococcus lactis afin de déterminer leurs spécificités ioniques et leurs caractéristiques biochimiques. Le système d'expression procaryote L. lactis a été mis en place au laboratoire et s'avère parfaitement adapté à la production de protéines membranaires de plantes. Ce système a permis de produire plusieurs protéines membranaires d'Arabidopsis, dont HMA1 et PAA1, en quantités compatibles avec des analyses biochimiques. Nous avons déterminé les conditions de solubilisation et de purification de ces deux protéines. Nous n'avons pas pu mesurer d'activité ATPase associée à ces protéines. En revanche, nos données indiquent que ces deux protéines recombinantes peuvent lier l'un de leur substrat ; l'ATP. Nous avons aussi pu démontrer que PAA1 peut lier du cuivre sous forme 1+ et sous forme 2+. Au bilan, ces données suggèrent que le contrôle de l'homéostasie du cuivre chloroplastique requiert plusieurs systèmes de transport indépendants et une régulation fine de ces voies d'import de cuivre afin d'alimenter les besoins liés à la photosynthèse et les besoins liés aux mécanismes de résistance aux stress oxydatifs.
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Blanchette, Marie. "Acheminement et chimiorsistance, deux grandes limitations dans le traitement des tumeurs crbrales." Thèse, Universit de Sherbrooke, 2014. http://savoirs.usherbrooke.ca/handle/11143/5344.

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Les gliomes malins constituent les tumeurs crbrales primaires les plus agressives et le glioblastome (GBM) est la plus frquente et agressive dentre elles. La survie mdiane associe nest que de 14,6 mois. D au caractre hautement invasif de ces tumeurs, la rsection maximale de la tumeur doit imprativement tre suivie de traitement de radio- et/ou chimiothrapie. Cependant, la prsence de la barrire hmatoencphalique et des mcanismes de chimiorsistance, tels que les pompes efflux, limitent lacheminement et lefficacit des composs aux cellules tumorales. Louverture osmotique de la barrire hmatoencphalique (OBHE) a t dveloppe afin damliorer lacheminement dagents anti-noplasiques au cerveau et la tumeur. Bien que plusieurs tudes aient t effectues afin de caractriser son processus, beaucoup dinformations restent dcouvrir afin dapprofondir nos connaissances sur lOBHE et amliorer son application en clinique. Avec lobjectif ultime de contourner ces deux obstacles, jai caractris le processus dynamique de lOBHE pour deux molcules de tailles diffrentes par imagerie par rsonance magntique dynamique, ainsi que pour une molcule tant un substrat des pompes efflux par tomographie dmission par positron dans le modle murin Fischer-F98. Jai galement tudi lexpression et la localisation de diffrentes pompes efflux par PCR quantitative et immunohistochimie dans des spcimens de gliomes malins. Les rsultats obtenus dmontrent que la barrire hmato-tumorale limite lacheminement la tumeur de composs de diffrent poids molculaire. Lacheminement au parenchyme crbral et la tumeur suite une procdure dOBHE est aussi dpendant du poids molculaire et de la taille de la molcule acheminer. LOBHE moins dtre de qualit excellente, ne semble pas suffisante pour acheminer au parenchyme crbral des substrats des pompes efflux. Les GBM expriment la MRP1, MRP3 et BCRP diffrents niveaux. La PGP, MRP1 et BCRP sont exprimes par les cellules endothliales des microvaisseaux crbraux. Lensemble de ces rsultats suggre que ladministration dagents thrapeutiques suite la procdure dOBHE doit tre optimise selon lagent administr et que linhibition de pompes efflux ou une autre stratgie rendant les agents de chimiothrapie invisibles aux pompes efflux sera bnfique pour amliorer leur acheminement au systme nerveux central et aux cellules tumorales.
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Dvořák, Dalibor. "Termální lázně Yverdon, pět smyslů v architektuře." Master's thesis, Vysoké učení technické v Brně. Fakulta architektury, 2015. http://www.nusl.cz/ntk/nusl-216175.

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Object of the thermes is located in a compact cube surrounded by water, which is located in the park. Baths are divided vertically into five levels according to function. Public baths, wellness, rehabilitation, physiotherapy.
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Čermáková, Tereza. "Termální lázně Yverdon, pět smyslů v architektuře." Master's thesis, Vysoké učení technické v Brně. Fakulta architektury, 2015. http://www.nusl.cz/ntk/nusl-216165.

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LEŠŇOVSKÁ, Lenka. "Hra zraku a hmatu." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-253323.

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The thesis is specialized in the creation of teaching aids for preschool and early school age children. The work consists of two parts - theoretical and practical. The theoretical part is characterized by psychological human development with an emphasis on the development of preschool and early school age children. The thesis is focused on the life and work of reform pedagogue Maria Montessori. The theoretical part is discussed about learning, the use of educational games and educational aids. In educational process is very important a teacher. The practical part consists of teaching aids - the alphabet, numbers, and developing a sense of small tasks which are normally used in dressing up.
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TILPOVÁ, Alexandra. "Vytvoření metodických listů sportovní masáže." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-53509.

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The aim of the thesis is to create methodological papers that will serve to teach or practice massage. There is outlined the history and the beginning of the word massage. There are deseribed the masseur touches, their technique and indications. The suitability and unsuitability of massage, effects, effects on the human body. It lists and uses of funds and equipment for sports massage. Based on the literature and captured images are developed methodology sheets for your convenience and are accompanied by photographs. The leaves have been tested in practice, a masseur in the fitness center.
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Ticháčková, Klára. "Test hmatového vnímání - "Tactual profile" pro žáky mladšího školního věku se zrakovým postižením." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397373.

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This diploma thesis deals with the Tactual Profile test of tactile perception and is aimed at pupils of younger school age with severe visual impairment. The theoretical part is devoted to topics of visual impairment, tactile perception, other compensatory senses and specifics in the development of visually impaired children in preschool age. The theoretical background of the work is supplemented by current studies from the American environment dealing with the importance of developing children's tactile perception in connection with subsequent Braille teaching. The thesis contains a detailed description of Tactual Profile, including material history and theoretical basis. Then it is followed by the research part, which was processed by the quantitative method. The results obtained by testing were processed into graphs according to individual material categories. The thesis also includes two examination reports as an example of possible evaluation in practice. The aim of this thesis is to determine the level of tactile perception in younger school age children with severe visual impairment by Tactual Profile. Another intention is to create an abbreviated version of this test, which could form a proposal for functional examination of touch in school and counseling practice. This abbreviated version...
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Pecková, Hana. "Vliv bowenových masáží na výkonost koně." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-169730.

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Books on the topic "HMATE1"

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Jestřáb, Vojtěch. Hmatat až k nahotě. Brno: Doplněk, 2000.

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Jaros, P. Lasky hmat. Bratislava: Slovensky spisovatel, 1988.

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Jaroš, Peter. Lásky hmat. Bratislava: Slovenský spisovatelʹ, 1988.

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Alvaro, Almeida, ed. Cra$hmaker: A federal affaire : a novel. [S.l.]: V. Sperandeo & A. Almeida, 2000.

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Berndt, Bruce, and Robert Rankin, eds. Ramanujan: Essays and Surveys. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022.

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Wīn, Htūn Hmat. Selected writings of Sao Tun Hmat Win. Yangon: Myanmar Historical Commission, 2004.

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Book chapters on the topic "HMATE1"

1

Iwamoto, Ryo, Eisuke Mekada, Thomas G. Hofmann, Eva Krieghoff-Henning, Masaaki Kobayashi, Ken Takamatsu, Jennifer Defren, et al. "HMAT1." In Encyclopedia of Signaling Molecules, 871. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100620.

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Chandrasekhar, S. "An incident in the life of S. Ramanujan, F.R.S.: Conversations with G. H. Hardy, F.R.S. and J. E. Littlewood, F.R.S. and their sequel." In Ramanujan: Essays and Surveys, 77–79. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022/10.

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Berndt, Bruce C. "S. Janaki Ammal (Mrs. Ramanujan)." In Ramanujan: Essays and Surveys, 83–87. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022/11.

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Berndt, Bruce C. "A short biography of S. Narayana Iyer." In Ramanujan: Essays and Surveys, 97–98. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022/13.

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Aiyar, S. Narayana. "The distribution of primes." In Ramanujan: Essays and Surveys, 99–100. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022/14.

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Aiyar, S. Narayana. "Some theorems in summation." In Ramanujan: Essays and Surveys, 101–3. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022/15.

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Selberg, Atle. "Reflections around the Ramanujan centenary." In Ramanujan: Essays and Surveys, 203–13. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022/24.

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Berndt, Bruce C., Youn-Seo Choi, and Soon-Yi Kang. "The problems submitted by Ramanujan to the Journal of the Indian Mathematical Society." In Ramanujan: Essays and Surveys, 215–58. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022/25.

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Dyson, Freeman J. "A walk through Ramanujan’s garden." In Ramanujan: Essays and Surveys, 261–75. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022/26.

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Askey, R. "Ramanujan and hypergeometric and basic hypergeometric series." In Ramanujan: Essays and Surveys, 277–324. Providence, Rhode Island: American Mathematical Society, 2001. http://dx.doi.org/10.1090/hmath/022/27.

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Conference papers on the topic "HMATE1"

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Mlynczak, Martin G., David G. Johnson, and David P. Kratz. "The Far-Infrared Spectrum: Exploring a New Frontier in the Remote Sensing of the Earth’s Climate." In Hyperspectral Imaging and Sounding of the Environment. Washington, D.C.: OSA, 2007. http://dx.doi.org/10.1364/hise.2007.hma1.

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Goldberg, Mitch, James Gleason, Robert Murphy, Carl Hoffman, and John Furgerson. "NOAA’s Joint Polar Satellite System and the NPP Satellite Delivering the Next Generation of Environmental Earth Observations." In Hyperspectral Imaging and Sounding of the Environment. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/hise.2011.hma1.

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Anderson, James, John Dykema, and Stephen Leroy. "High Accuracy Observations of Spectrally Resolved IR Radiance from Earth Orbit: Setting the Time Scale in the Energy-Climate Debate." In Hyperspectral Imaging and Sensing of the Environment. Washington, D.C.: OSA, 2009. http://dx.doi.org/10.1364/hisense.2009.hma1.

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Reports on the topic "HMATE1"

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McNamara, Joy, and Andrew Duncan. HMAT QUARTERLY PROGRESS REPORT Q2 KPFM. Office of Scientific and Technical Information (OSTI), April 2019. http://dx.doi.org/10.2172/1544619.

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McNamara, Joy. HMAT Q3 PROGRESS REPORT ON KPFM STUDIES. Office of Scientific and Technical Information (OSTI), August 2019. http://dx.doi.org/10.2172/1547279.

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