Dissertations / Theses on the topic 'HLA Hart'
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Waddell, Sarah Kathleen. "The Role of the 'Legal Rule' in Indonesian Law: environmental law and the reformasi of water management." University of Sydney. Environmental Law, 2004. http://hdl.handle.net/2123/673.
Full textZhou, Han-Ru. "Implied constitutional principles." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ca2491fc-a372-4adc-afe0-2f832fcc7082.
Full textHaida, Amal. "Blessure, environnement et performance de haut niveau." Rouen, 2014. https://hal-insep.archives-ouvertes.fr/tel-01788566.
Full textThe thesis deals with the epidemiology and physiopathology of performance in elite sport. The objective is to analyze the impact of two parameters that can affect performance and its development during a sports career: injury and environmental factors. At first, we study the impact of the Anterior Cruciate Ligament (ACL) rupture on the performance of the best alpine skiers (1st decile of performance) in the French Team since 1980. Through a transversal study, we analyze the return to performance after an ACL injury and evaluate whether the injury is a handicap in post-rupture performance. It is also an opportunity to demonstrate and compare the performance of the best skiers who had a torn ACL with those who never suffered this injury during their career. Secondly, a second longitudinal study analyses the performance development of the entire alpine skiers in the French Team during their career in injured and non injured athletes since 1980. Moreover, in alpine skiing the environment plays a role in the occurrence of injuries. The snow conditions, weather conditions and temperature are all factors that influence the prevalence of injuries, including the ACL rupture. Thus, in a third study we evaluated the impact of seasonality and environment in the sprint and middle distance. This study was conducted in athletics because it represents one of the oldest Olympic sports with sufficient data available allowing a substantial historical perspective of performance. Our studies describe the importance of taking into account the injury and the environment, particularly temperature, in the multifactorial context of performance optimization in elite sport
Balbuena, Valenzuela Juan Pablo. "Development of innovative silicon radiation detectors." Doctoral thesis, Universitat Autònoma de Barcelona, 2011. http://hdl.handle.net/10803/96361.
Full textAxelsson, Camilla, and Josefin Karlsson. "Hela min själ är fylld utav sår : En studie utifrån kvinnors egna upplevelser av att leva med självskadebeteende." Thesis, Linnéuniversitetet, Institutionen för socialt arbete (SA), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-39550.
Full textCannon, Joanna Erin. "Effectiveness of a Computer-Based Syntax Program in Improving the Morphosyntax of Students Who are Deaf/Hard of Hearing." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/epse_diss/63.
Full textIvsjö, Clara, and Maria Haglöf. ""I den bästa av världar skulle man haft ännu mer samarbete, hela tiden" : En kvalitativ studie om nybyggnation av en stadsdelspark ur ett brottsförebyggande- och trygghetsskapande perspektiv." Thesis, Högskolan i Gävle, Kriminologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-33061.
Full textThe purpose of our study has been to examine, from a crime prevention- and safety perspective, the cooperation between key-actors in creating an urban park. Material from semi-structured interviews with key- actors as well as documents relating to the process have been the basis for a qualitative content analysis. The theoretical framework we have used is routine activity theory, situational crime prevention and CPTED. The result showed that cooperation between the parties was not present in the initial planning. Furthermore, everyone involved emphasizes that it could be a lesson for future projects, which possibly could have resulted in another embodiment of the park in some respects. The complexity of balancing crime prevention and aesthetic measures is highlighted, and the action that is now being taken are to address problems that have arisen. Which could possibly have been prevented if it had been considered in the planning.
Payet, Matthieu. "Conception de systèmes programmables basés sur les NoC par synthèse de haut niveau : analyse symbolique et contrôle distribué." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSES051/document.
Full textNetwork-on-Chip (NoC) introduces parallelism in communications and emerges with the growing integration of circuits as large designs need scalable communication architectures. This introduces the separation between communication tasks and processing tasks, and makes the design with NoC more complex. High level synthesis (HLS) tools can help designers to quickly generate high quality HDL (Hardware Description Level) designs. But their control schemes are centralized, usually using finite state machines. To take benefit from parallel algorithms and the ever growing FPGAs, HLS tools must properly extract the parallelism from the input representation and use the available resources efficiently. Algorithm designers are used with programming languages. This behavioral specification has to be enriched with architectural details for a correct optimization of the generated design. The C to FPGA path is not straightforward, and the need for architectural knowledges limits the adoption of FPGAs, and more generally, parallel architecture. In this thesis, we present a method that uses a symbolic analysis technique to extract the parallelism of an algorithmic specification written in a high level language. Parallelization skills are not required from the users. A methodology is then proposed for adding NoCs in the automatic design generation that takes the benefit of potential parallelizations. To dimension the design, we estimate the design resource consumption using a mathematical model for the NoC. A scalable application, hardware specific, is then generated using a High Level Synthesis flow. We provide a distributed mechanism for data path reconfiguration that allows different applications to run on the same set of processing elements. Thus, the output design is programmable and has a processor-less distributed control. This approach of using NoCs enables us to automatically design generic architectures that can be used on FPGA servers for High Performance Reconfigurable Computing. The generated design is programmable. This enable users to avoid the logic synthesis step when modifying the algorithm if a existing design provide the needed operators
Li, Charles Cheuk Him. "Limits of the real : a hypertext critical edition of Bhartṛhari's Dravyasamuddeśa, with the commentary of Helārāja." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284085.
Full textVallés, Lluch Ana. "P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity." Doctoral thesis, Universitat Politècnica de València, 2008. http://hdl.handle.net/10251/3795.
Full textVallés Lluch, A. (2008). P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/3795
Palancia
Mena, morales Valentin. "Approche de conception haut-niveau pour l'accélération matérielle de calcul haute performance en finance." Thesis, Ecole nationale supérieure Mines-Télécom Atlantique Bretagne Pays de la Loire, 2017. http://www.theses.fr/2017IMTA0018/document.
Full textThe need for resources in High Performance Computing (HPC) is generally met by scaling up server farms, to the detriment of the energy consumption of such a solution. Accelerating HPC application on heterogeneous platforms, such as FPGAs or GPUs, offers a better architectural compromise as they can reduce the energy consumption of a deployed system. Therefore, a change of programming paradigm is needed to support this heterogeneous acceleration, which trickles down to an increased level of programming complexity tackled by software experts. This is most notably the case for developers in quantitative finance. Applications in this field are constantly evolving and increasing in complexity to stay competitive and comply with legislative changes. This puts even more pressure on the programmability of acceleration solutions. In this context, the use of high-level development and design flows, such as High-Level Synthesis (HLS) for programming FPGAs, is not enough. A domain-specific approach can help to reach performance requirements, without impairing the programmability of accelerated applications.We propose in this thesis a high-level design approach that relies on OpenCL, as a heterogeneous programming standard. More precisely, a recent implementation of OpenCL for Altera FPGA is used. In this context, four main contributions are proposed in this thesis: (1) an initial study of the integration of hardware computing cores to a software library for quantitative finance (QuantLib), (2) an exploration of different architectures and their respective performances, as well as the design of a dedicated architecture for the pricing of American options and their implied volatility, based on a high-level design flow, (3) a detailed characterization of an Altera OpenCL platform, from elemental operators, memory accesses, control overlays, and up to the communication links it is made of, (4) a proposed compilation flow that is specific to the quantitative finance domain, and relying on the aforementioned characterization and on the description of the considered financial applications (option pricing)
Ben, Hammouda Mohamed. "A design flow to automatically Generate on chip monitors during high-level synthesis of Hardware accelarators." Thesis, Brest, 2014. http://www.theses.fr/2014BRES0115/document.
Full textEmbedded systems are increasingly used in various fields like transportation, industrial automation, telecommunication or healthcare to execute critical applications and manipulate sensitive data. These systems often involve financial and industrial interests but also human lives which imposes strong safety constraints.Hence, a key issue lies in the ability of such systems to respond safely when errors occur at runtime and prevent unacceptable behaviors. Errors can be due to natural causes such as particle hits as well as internal noise, integrity problems, but also due to malicious attacks. Embedded system architecture typically includes processor (s), memories, Input / Output interface, bus controller and hardware accelerators that are used to improve both energy efficiency and performance. With the evolution of applications, the design cycle of hardware accelerators becomes more and more complex. This complexity is partly due to the specification of hardware accelerators traditionally based on handwritten Hardware Description Language (HDL) files. However, High-Level Synthesis (HLS) that promotes automatic or semi-automatic generation of hardware accelerators according to software specification, like C code, allows reducing this complexity.The work proposed in this document targets the integration of verification support in HLS tools to generate On-Chip Monitors (OCMs) during the high-level synthesis of hardware accelerators (HWaccs). Three distinct contributions are proposed. The first one consists in checking the Input / Output timing behavior errors (synchronization with the whole system) as well as the control flow errors (illegal jumps or infinite loops). On-Chip Monitors are automatically synthesized and require no modification in their high-level specification. The second contribution targets the synthesis of high-level properties (ANSI-C asserts) that are added into the software specification of HWacc. Synthesis options are proposed to trade-off area overhead, performance impact and protection level. The third contribution improves the detection of data corruptions that can alter the stored values or/and modify the data transfers without causing assertions violations or producing illegal jumps. Those errors are detected by duplicating a subset of program’s data limited to the most critical variables. In addition, the properties over the evolution of loops induction variables are automatically extracted from the algorithmic description of HWacc. It should be noticed that all the proposed approaches, in this document, allow only detecting errors at runtime. The counter reaction i.e. the way how the HWacc reacts if an error is detected is out of scope of this work
Ye, Haixiong. "Impact des transformations algorithmiques sur la synthèse de haut niveau : application au traitement du signal et des images." Phd thesis, Université Paris Sud - Paris XI, 2014. http://tel.archives-ouvertes.fr/tel-01061200.
Full textRibon, Aurélien. "Amélioration du processus de vérification des architectures générées à l'aide d'outils de synthèse de haut-niveau." Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14719/document.
Full textThe fast growing complexity of hardware circuits, during the last three decades, has change devery step of their development cycle. Design methods evolved a lot, and this evolutionwas necessary to cope with an always shorter time-to-market, mainly driven by the internationalcompetition.An increased complexity also means more errors, harder to find corner-cases, and morelong and expensive simulations. The verification of hardware systems requires more andmore resources, and is the main cost factor of the whole development of a circuit. Since thecomplexity of any system increases, the cost of an error undetected until the foundry stepbecame prohibitive. Therefore, the verification process is divided between multiple stepsinvolved at every moment of the design process : comparison of models behavior, simulationof RTL descriptions, formal analysis of algorithms, assertions usage, etc. The verificationmethodologies evolved a lot, in order to follow the progress of design methods. Somemethods like the Assertion-Based Verification became so important that they are nowwidely adopted among the developers community, providing near-source error detection.Thus, the work described here aims at improving the assertion-based verification process,in order to offer a consequent timing improvment to designers. Two contributions aredetailed. The first one deals with the transformation of Boolean assertions found in algorithmicdescriptions into equivalent temporal assertions in the RTL description generatedby high-level synthesis (HLS) methodologies. Therefore, the assertions are usable duringthe simulation process of the generated architectures. The second contribution targets theverification of hardware systems in real-time. It details the synthesis process of a hardwareerror manager, which has to save and serialize the execution context when an error isdetected. Thus, it is easier to understand the cause of an error and to find its source. Theerrors and their contexts are serialized as reports in a memory readable by the system ordirectly by the designer. The behavior of a circuit can be analyzed without requiring anyprobe or integrated logic analyzer
Ben, Jmaa Chtourou Yomna. "Implémentation temps réel des algorithmes de tri dans les applications de transports intelligents en se basant sur l'outil de synthèse haut niveau HLS." Thesis, Valenciennes, 2019. http://www.theses.fr/2019VALE0013.
Full textIntelligent transport systems play an important role in minimizing accidents, traffic congestion, and air pollution. Among these systems, we mention the avionics domain, which uses in several cases the sorting algorithms, which are one of the important operations for real-time embedded applications. However, technological evolution is moving towards more and more complex architectures to meet the application requirements. In this respect, designers find their ideal solution in reconfigurable computing, based on heterogeneous CPU / FPGA architectures that house multi-core processors (CPUs) and FPGAs that offer high performance and adaptability to real-time constraints. Of the application. The main objective of my work is to develop hardware implementations of sorting algorithms on the heterogeneous CPU / FPGA architecture by using the high-level synthesis tool to generate the RTL design from the behavioral description. This step requires additional efforts on the part of the designer in order to obtain an efficient hardware implementation by using several optimizations with different use cases: software, optimized and nonoptimized hardware and for several permutations / vectors generated using the generator pf permutation based on Lehmer method. To improve performance, we calculated the runtime, standard deviation and resource number used for sorting algorithms by considering several data sizes ranging from 8 to 4096 items. Finally, we compared the performance of these algorithms. This algorithm will integrate the applications of decision support, planning the flight plan
Rubattu, Claudio. "Response time analysis of parameterized dataflow applications on heterogeneous SW/HW systems." Thesis, Rennes, INSA, 2020. http://www.theses.fr/2020ISAR0005.
Full textIn contexts such as embedded and cyber-physical systems, the design of a desired functionality under constraints increasingly requires a parallel execution of different tasks on heterogeneous architectures. The nature of such parallel systems implies a huge complexity in understanding and predicting performance in terms of response time. Indeed, response time depends on many factors associated with the characteristics of both the functionality and the target architecture. State-of-the art strategies derive response time by examining the operations required by each task for both processing and accessing shared resources. This procedure is often followed by the addition or elimination of potential interferences due to task concurrency. However, such approaches require an advanced knowledge of the software and hardware details, rarely available in practice. This thesis provides an alternative "topdown" strategy aimed at extending the cases in which hardware and software response times can be analyzed and predicted. The proposed strategy leverages on dataflow-based application representations and focuses on the response time estimation of reconfigurable applications mapped on both general-purpose and specialized processing elements
Chavet, Cyrille. "Synthèse automatique d'interfaces de communication matérielles pour la conception d'applications du domaine du traitement du signal." Phd thesis, Université de Bretagne Sud, 2007. http://tel.archives-ouvertes.fr/tel-00369043.
Full textHesková, Veronika. "Příprava a realizace výstavby výrobní haly s administrativou." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2019. http://www.nusl.cz/ntk/nusl-392062.
Full textFrahm, Marc. "The Immune Response to Acute HIV-1 Infection and the Effect of HAART and HLA Alleles on the Control of Viral Replication." Diss., 2012. http://hdl.handle.net/10161/6139.
Full textA fraction of HIV-1 patients are able to successfully control the virus and avoid developing AIDS. It has become increasingly clear that variations in the immune response during the initial days of acute infection including the period of peak viral replication determine long term differences in disease outcomes. While the precise factor(s) necessary and sufficient for protection from AIDS is as yet unidentified, a number of factors have been correlated with protection from AIDS. Among these are the presence of a strong proliferative and multifunctional T-cell response as well as the HLA allele status of a patient. Therefore the goal of this thesis project was to 1) broadly identify the major contributors to the proliferative and multifunctional T-cell response during acute infection with HIV, 2) examine the durability of these responses and 3) elucidate the gene regulation pathway(s) by which HLA allele status determines disease outcomes.
In order to identify the major contributors to the proliferative and multifunctional T-cell response to HIV we utilized PBMC samples from a cohort of acutely infected HIV patients in the Duke and University of North Carolina infectious disease clinics. These samples were stimulated in vitro with peptides representing the HIV clade B consensus sequence and the T-cells were analyzed for proliferation and multifunctionality. Through this analysis we identified CD4+CD8+ (DP) T-cells as overrepresented within the proliferative response and the primary contributor to multifunctionality. Additionally, the acute multifunctional T-cell response was highly focused on the Nef, Rev, Tat, VPR and VPU sections of the HIV proteome. We also discovered similar response patterns among a cohort of HIV controllers recruited from the Duke infectious disease clinic. In fact, the frequency of multifunctional DP T-cells was inversely correlated with viral loads among the controller cohort.
Having identified DP T-cells as HIV responding cells of interest, we next examined their durability following the removal of widespread antigenic stimulation via administration of HAART. Utilizing longitudinal samples from the acute HIV cohort we again examined T-cell proliferation and multifunctionality at approximately 24 weeks and 104 weeks post infection among patients. This experiment demonstrated that among patients who initiated HAART during acute infection there was a significant reduction in the frequency of multifunctional DP T-cells at 24 and 104 weeks post infection compared to study entry. Meanwhile the proliferative DP T-cell response was maintained longitudinally. Additionally, these patients did not exhibit the previously described increase in frequency of multifunctional CD8 T-cells as infection progressed to the chronic phase. Although the majority of patients initiated HAART during the acute stage of infection, a minority delayed HAART initiation for various lengths up to and including study cessation. Among this group of patients the frequency of multifunctional DP T-cells was maintained longitudinally. Therefore, the early initiation of HAART reduces long term frequencies of multifunctional DP T-cells while delayed HAART initiation leads to a durable multifunctional DP T-cell response. Since HIV controllers with higher frequencies of multifunctional DP T-cells maintain lower viral loads, early HAART initiation may be detrimental to the development of immune cells capable of controlling the virus.
Finally, we examined the effect HLA alleles have on gene regulation during the initial interactions between HIV and the host immune system. This work employed 2 HIV negative patient cohorts. One cohort expressed HLA-B*35 which has previously been shown to correlate with rapid progression to AIDS following infection with HIV. The second cohort expressed HLA-B*57 which has been associated with long term non-progression following infection with HIV. PBMCs from each group were infected with HIV in vitro. Twenty-four hours after infection these cells were sorted into CD4+ T-cells, CD8+ T-cells and NK-cells. Following cell sorting, mRNA was isolated and interrogated for expression changes using whole genome microarrays. This analysis revealed HLA allele specific differences in the magnitude by which CD4+ T-cells, CD8+ T-cells and NK-cells activate the interferon response pathway following exposure to HIV.
In total, these findings provide insight into the cell types responsible for significant portions of the acute immune response to HIV and the mechanisms by which individuals protected from progression to AIDS differ from their peers.
Dissertation
VIJAYARAGHAVAN, V. "Exploration des liens entre la synthèse de haut niveau (HLS) et la synthèse au niveau transferts de registres (RTL)." Phd thesis, 1996. http://tel.archives-ouvertes.fr/tel-00010764.
Full textTyler, John. "A Pragmatic Standard of Legal Validity." Thesis, 2012. http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10885.
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