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ZHANG, CUI, and RICHARD F. WALTERS. "AN ABSTRACT, SHARED AND PERSISTENT DATA STRUCTURE FOR SUPPORTING DATABASE MANAGEMENT AND MULTILINGUAL NATURAL LANGUAGE PROCESSING." International Journal of Software Engineering and Knowledge Engineering 03, no. 03 (September 1993): 369–82. http://dx.doi.org/10.1142/s0218194093000173.
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Neither today’s general purpose programming environment nor high-level programming languages, including those designed for AI purposes, provide adequate support for database systems. Furthermore, non-English language databases are difficult to treat either in existing database systems or with current high-level languages, because they require culture-sensitive operations on multiple foreign character sets. In this paper, we present an abstract, shared and persistent data structure, called HL+, capable of supporting database management applications. We also describe the means for coping with the aforementioned problems by accessing HL+ features of database management from high-level programming languages with an extensible programmable high-level language interface. Extensions to the data structure to accommodate processing of multiple foreign character strings are also described, and examples of multilingual applications are given.
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Mukka, Milla, Samuli Pesälä, Charlotte Hammer, Pekka Mustonen, Vesa Jormanainen, Hanna Pelttari, Minna Kaila, and Otto Helve. "Analyzing Citizens’ and Health Care Professionals’ Searches for Smell/Taste Disorders and Coronavirus in Finland During the COVID-19 Pandemic: Infodemiological Approach Using Database Logs." JMIR Public Health and Surveillance 7, no. 12 (December 7, 2021): e31961. http://dx.doi.org/10.2196/31961.
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Background The COVID-19 pandemic has prevailed over a year, and log and register data on coronavirus have been utilized to establish models for detecting the pandemic. However, many sources contain unreliable health information on COVID-19 and its symptoms, and platforms cannot characterize the users performing searches. Prior studies have assessed symptom searches from general search engines (Google/Google Trends). Little is known about how modeling log data on smell/taste disorders and coronavirus from the dedicated internet databases used by citizens and health care professionals (HCPs) could enhance disease surveillance. Our material and method provide a novel approach to analyze web-based information seeking to detect infectious disease outbreaks. Objective The aim of this study was (1) to assess whether citizens’ and professionals’ searches for smell/taste disorders and coronavirus relate to epidemiological data on COVID-19 cases, and (2) to test our negative binomial regression modeling (ie, whether the inclusion of the case count could improve the model). Methods We collected weekly log data on searches related to COVID-19 (smell/taste disorders, coronavirus) between December 30, 2019, and November 30, 2020 (49 weeks). Two major medical internet databases in Finland were used: Health Library (HL), a free portal aimed at citizens, and Physician’s Database (PD), a database widely used among HCPs. Log data from databases were combined with register data on the numbers of COVID-19 cases reported in the Finnish National Infectious Diseases Register. We used negative binomial regression modeling to assess whether the case numbers could explain some of the dynamics of searches when plotting database logs. Results We found that coronavirus searches drastically increased in HL (0 to 744,113) and PD (4 to 5375) prior to the first wave of COVID-19 cases between December 2019 and March 2020. Searches for smell disorders in HL doubled from the end of December 2019 to the end of March 2020 (2148 to 4195), and searches for taste disorders in HL increased from mid-May to the end of November (0 to 1980). Case numbers were significantly associated with smell disorders (P<.001) and taste disorders (P<.001) in HL, and with coronavirus searches (P<.001) in PD. We could not identify any other associations between case numbers and searches in either database. Conclusions Novel infodemiological approaches could be used in analyzing database logs. Modeling log data from web-based sources was seen to improve the model only occasionally. However, search behaviors among citizens and professionals could be used as a supplementary source of information for infectious disease surveillance. Further research is needed to apply statistical models to log data of the dedicated medical databases.
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Mao, Ying, Tao Xie, and Ning Zhang. "Chinese Students’ Health Literacy Level and Its Associated Factors: A Meta-Analysis." International Journal of Environmental Research and Public Health 18, no. 1 (December 29, 2020): 204. http://dx.doi.org/10.3390/ijerph18010204.
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Health Literacy (HL) is an important determinant of health. Many scholars have conducted a large number of studies on the level of Chinese students’ HL and its associated factors. However, previous studies on HL level and the factors that influence it have been contradictory. Therefore, this systematic review and meta-analysis was conducted to estimate the level of Chinese students’ HL and its three dimensions (knowledge, behavior and skills) and to identify factors associated with HL in Chinese students. Two investigators independently searched literature, selected research and extracted data through comprehensively searching of four international electronic databases and three Chinese electronic database to identify all relevant observational studies on affecting factors for HL in Chinese students published in English and Chinese from database January, 2010 to September, 2020. In total, 61 articles were extracted in the study. The results showed that the level rates of HL and its three dimensions were 26%, 35%, 26%, 51%, respectively. For Chinese students, the significant factors were urban residents, senior class students, well performance at school, the Han nationality, focus on health knowledge, less exposure to video games, highly educated parents, income of one-child families, receiving health education, having medical background. This study provides some inspirations for improving the level of Chinese students’ HL and their health. First, the findings may help Chinese policy makers understand the overall HL of Chinese students and their levels across three dimensions (knowledge, behavior and skills). Second, protective factors for Chinese students’ HL were found in this research, which will help to improve the level of Chinese students’ HL, stimulate students’ awareness of prevention, and lay the foundation for a healthy China.
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Burghardt, Kyle J., Bradley H. Howlett, Audrey S. Khoury, Stephanie M. Fern, and Paul R. Burghardt. "Three Commonly Utilized Scholarly Databases and a Social Network Site Provide Different, But Related, Metrics of Pharmacy Faculty Publication." Publications 8, no. 2 (April 1, 2020): 18. http://dx.doi.org/10.3390/publications8020018.
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Scholarly productivity is a critical component of pharmacy faculty effort and is used for promotion and tenure decisions. Several databases are available to measure scholarly productivity; however, comparisons amongst these databases are lacking for pharmacy faculty. The objective of this work was to compare scholarly metrics from three commonly utilized databases and a social networking site focused on data from research-intensive colleges of pharmacy and to identify factors associated with database differences. Scholarly metrics were obtained from Scopus, Web of Science, Google Scholar, and ResearchGate for faculty from research-intensive (Carnegie Rated R1, R2, or special focus) United States pharmacy schools with at least two million USD in funding from the National Institutes of Health. Metrics were compared and correlations were performed. Regression analyses were utilized to identify factors associated with database differences. Significant differences in scholarly metric values were observed between databases despite the high correlations, suggestive of systematic variation in database reporting. Time since first publication was the most common factor that was associated with database differences. Google Scholar tended to have higher metrics than all other databases, while Web of Science had lower metrics relative to other databases. Differences in reported metrics between databases are apparent, which may be attributable to the time since first publication and database coverage of pharmacy-specific journals. These differences should be considered by faculty, reviewers, and administrative staff when evaluating scholarly performance.
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Ran, Xue, Yalan Chen, Kui Jiang, and Yaqin Shi. "The Effect of Health Literacy Intervention on Patients with Diabetes: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 19, no. 20 (October 12, 2022): 13078. http://dx.doi.org/10.3390/ijerph192013078.
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Relevant studies published between January 2010 and June 2021 were identified through relevant databases, including the Science Citation Index Expanded (SCIE) database of Web of Science, PubMed, and Embase, in order to assess the effect of health literacy (HL) intervention on patients with diabetes. A total of 21 articles were eligible. The results showed that: (1) this review involved different HL assessment tools, most of which were self-designed scales and assessment tools focused on measuring functional HL. (2) The differences in glycosylated hemoglobin (HbA1c) (weighted mean difference [WMD] = −0.78, 95% confidence interval [CI]: −0.94, −0.62) and medication adherence (standardized mean difference [SMD] = 1.85, 95% CI: 0.19, 3.52) between the HL intervention group and the usual care group were statistically significant. There was no significant improvement in systolic blood pressure (SMD = −0.05, 95% CI: −0.34, 0.25). Furthermore, this review reported that self-efficacy (SMD = 0.85, 95% CI: 0.65, 1.04) was increased, and the level of HL was improved. In the assessments of risk of bias, 90% of the studies were classified as medium. The quality of the evidence of medication adherence was very low, and the reliability of the conclusions was not enough to confirm the effect of HL.
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Wang, Ruihong, Jianguo Wang, Stratos Idreos, M. Tamer Özsu, and Walid G. Aref. "The case for distributed shared-memory databases with RDMA-enabled memory disaggregation." Proceedings of the VLDB Endowment 16, no. 1 (September 2022): 15–22. http://dx.doi.org/10.14778/3561261.3561263.
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Memory disaggregation (MD) allows for scalable and elastic data center design by separating compute (CPU) from memory. With MD, compute and memory are no longer coupled into the same server box. Instead, they are connected to each other via ultra-fast networking such as RDMA. MD can bring many advantages, e.g., higher memory utilization, better independent scaling (of compute and memory), and lower cost of ownership. This paper makes the case that MD can fuel the next wave of innovation on database systems. We observe that MD revives the great debate of "shared what" in the database community. We envision that distributed shared-memory databases (DSM-DB, for short) - that have not received much attention before - can be promising in the future with MD. We present a list of challenges and opportunities that can inspire next steps in system design making the case for DSM-DB.
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Waheed, Anem, Angie Mae Rodday, Anita J. Kumar, Kenneth B. Miller, and Susan K. Parsons. "Hematopoietic Stem Cell Transplant Utilization in Relapsed/Refractory Hodgkin Lymphoma: A Population Level Analysis of Statewide Claims Data." Blood 132, Supplement 1 (November 29, 2018): 4771. http://dx.doi.org/10.1182/blood-2018-99-111921.
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Abstract Introduction: In the era of novel therapies, the first and subsequent lines of therapies are rapidly evolving in the treatment of patients with Hodgkin lymphoma (HL) in order to optimize disease control and reduce long term health risks. Hematopoietic stem cell transplant (HSCT) is often used following treatment failure. While utilization of HSCT can be ascertained from transplant-specific registries, the treatment path for patients with relapsed/refractory HL leading up to HSCT is largely unknown. We developed an algorithm to define a cohort of commercially insured patients with HL from 2009-2013 in the Massachusetts All Payer Claims Database (MA APCD) who received HSCT. Further, we describe treatment characteristics of this cohort. Methods: The Patient Protection and Affordable Care Act of 2010 established requirements for states to assess healthcare outcomes which resulted in at least 16 states establishing All Payer Claims Databases. The MA APCD provides detailed medical claims data, physician provider data, and pharmacy data for all commercially insured patients in the state, regardless of site of care. Moreover, each patient is assigned a unique identifier, which allows us to follow patients even if they change insurer ("insurance churning"). To our knowledge, no studies exist using APCD for HL from any state. We identified a cohort with HL who underwent HSCT during the study period from among 7,613 cases with ICD-9 diagnostic codes for HL and of those, 695 had ICD-9 codes for both HL and HSCT. To identify incident HSCT cases during our study period, we developed and iteratively refined an algorithm using ICD-9 diagnostic and procedure codes, dates of service, and length of stay which narrowed the cohort to 178 patients. After review of the medical and pharmacy claims databases by an oncologist (AW), 113 patients were identified as part of the final cohort who underwent autologous and/or allogeneic HSCT. Reasons for exclusion include not HL (34), not HSCT (8), and prevalent (i.e. "history of") HSCT only (23). We then summarized initial treatment, salvage treatment, and HSCT where data were available. Results: Among this commercially insured cohort of 113 patients who received HSCT, the median age was 39.0 years and 51.3% were female. Initial therapy data were identified for 65 of the 113 patients (58%); 58 (89.2%) received doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD). Of the 60 people for whom salvage therapy data could be discerned, 32 (53.3%) received ifosfamide, carboplatin, etoposide (ICE), 11 (18.3%) received gemcitabine, vinorelbine, liposomal doxorubicin (GVD), 11 (18.3%) received other chemotherapy, and 6 (10%) received brentuximab vedotin. Notably, 92 (81.4%) of all transplants were autologous, 10 (8.9%) were allogeneic transplant, and 9 (8.0%) were autologous followed by allogeneic transplant. Of the 64 patients with initial therapy data, median time to HSCT after completion of initial treatment was 238.5 days (25th-75th percentile, 151.5-428.0). Additionally, 25 HSCT were performed during the year 2009 and 20 of these had unknown initial chemotherapy regimens. Our dataset was limited to the years 2009-2013 and this missing chemotherapy information is most likely due to initial treatment prior to 2009. Conclusion: We successfully developed and refined an algorithm to help identify HSCT among patients with HL within a large statewide claims database. We characterized a cohort of patients with relapsed/refractory HL, including patterns of initial and salvage treatments in a sizeable subset of patients. Median time to HSCT demonstrates that the majority of patients undergo transplant for relapsed/refractory disease within a year of completing initial treatment. Future directions include determining reasons for incomplete information on initial and salvage therapy, such as insurance product or type, different sites of care within community and academic practices, and potential referral patterns into the state for HSCT care. As less than 5% of cancer patients are enrolled onto clinical trials, partnerships between clinical experts and data science are a powerful way to use large claims databases to study more representative patient populations. Table. Table. Disclosures Rodday: Seattle Genetics: Research Funding. Kumar:Seattle Genetics: Research Funding. Parsons:Seattle Genetics: Research Funding.
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Mandias, Green Ferry, Green Arther Sandag, Susi Susanti, and Haryanto Reza Musak. "Penerapan Algoritma K-Means Untuk Analisis Prestasi Akademik Mahasiswa Fakultas Ilmu Komputer Universitas Klabat." CogITo Smart Journal 3, no. 2 (December 12, 2017): 230. http://dx.doi.org/10.31154/cogito.v3i2.72.230-239.
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Universitas Klabat (UNKLAB) adalah salah satu perguruan tinggi swasta yang berada dibawah naungan organisasi Gereja Masehi Advent Hari Ketujuh, yang bertempat di Airmadidi, Sulawesi Utara. Universitas Klabat termasuk universitas yang sangat dikenal di Sulawesi utara, yang di dalamnya memiliki 1 program pascasarjana, 6 fakultas dan 1 akademik. Penelitian ini dilakukan untuk mengetahui pencapaian prestasi mahasiswa fakultas ilmu komputer yang berada pada tingkat 4 yang memiliki 52 mahasiswa yang aktif dengan memanfaatkan metode data mining. Berdasarkan data mahasiswa fakultas ilmu computer, penelitian ini dilakukan untuk mencari tahu berapa banyak mahasiswa yang memiliki prestasi akademik dibidang databases, networking dan programming dengan menggunakan algoritma data mining. Penelitian ini menggunakan algoritma K-Means dalam menganalisis prestasi akademik mahasiswa fakultas llmu komputer di Universitas Klabat. Data yang dianalisis dikelompokan terlebih dahulu agar terstruktur serta data yang dianalisis memiliki kejelasan hasil yang lebih dalam.Hasil yang didapat dari 52 mahasiswa tersebut adalah, 33% mahasiswa memiliki nilai prestasi di bidang database, 42% mahasiswa pada bidang networking dan 25% mahasiswa di bidang programming. Keywords : UNKLAB, Algoritma K-Means ,WEKA, Cluster, Data Mining.
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Manabe, Takashi, Hideko Yamamoto, and Makoto Kawai. "Studies on the procedure for the construction of cellular protein databases employing micro two-dimensional electrophoresis: An HL-60 protein database." Electrophoresis 16, no. 1 (1995): 407–22. http://dx.doi.org/10.1002/elps.1150160168.
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Selvi, T. Kalai, and S. Sasirakha. "Data Management Issues and Study on Heterogeneous Data Storage in the Internet of Things." Computer Science & Engineering: An International Journal 12, no. 6 (December 30, 2022): 27–34. http://dx.doi.org/10.5121/cseij.2022.12604.
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The Internet of Things is a networking standard that connects various hardware, including digital, physical, and virtual things that may communicate with one another and carry out user-requested tasks. Traditional database management methods cannot be used in this entity because of the variety, large volume and heterogeneous data generated by them. The rapid growth of heterogeneous data can only be managed by distributed and parallel computer systems and databases. When it comes to handling vast amount of diverse data, most relational databases have a variety of drawbacks because they were designed for a certain format. One of the most difficulties in data management is investigating such heterogeneous data. Consequently, IoT data management system design has to be considered with some distinct principles. These various guiding concepts enable the suggestion of various IoT data management system strategies. The solution should provide a unified format for the conversion of various heterogeneous data which are generated by the sensors. The integration of generated data is made simple by some middleware or architecture-oriented solutions. Other methods also offer effective storage of the unified data generated. This paper surveys the challenges of IoT Data management and provides a survey about the storage of heterogeneous data and the type of data used.
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Marinagi, Catherine, and Christos Skourlas. "Blended Learning in Personalized Assistive Learning Environments." International Journal of Mobile and Blended Learning 5, no. 2 (April 2013): 39–59. http://dx.doi.org/10.4018/jmbl.2013040103.
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In this paper, the special needs/requirements of disabled students and cost-benefits for applying blended learning in Personalized Educational Learning Environments (PELE) in Higher Education are studied. The authors describe how blended learning can form an attractive and helpful framework for assisting Deaf and Hard-of-Hearing (D-HH) students to learn and communicate. The described blended learning experiment integrates face-to-face, synchronous, and asynchronous e-learning, bilingual teaching (oral language and Sign Language) in the mainstream class, teaching in parallel classes, and personalized access to distributed databases of educational material. At the core of PELE, the authors use Multimedu, a web-based tailored made tool for disabled students. This experimental tool includes applications of a traditional Learning Management System (LMS), supporting a multilingual dictionary of terms, multimedia management and social networking. Finally, this paper describes the use of the blended e-learning model in “Database I” course, given at the Technological Educational Institute of Athens, Greece.
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Iyapparaja M and Deva Arul S. "Effective Feature Selection Using Hybrid GA-EHO for Classifying Big Data SIoT." International Journal of Web Portals 12, no. 1 (January 2020): 12–25. http://dx.doi.org/10.4018/ijwp.2020010102.
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Several novel applications and services of networking for the IoT are supported by the Social Internet of Things (SIoT) in a more productive and powerful way. SIoTs are the recent hot topics rather than other extensions of IoTs. In this research, the authors have extracted the Big Data SIoT using the well-known model named MapReduce framework. Moreover, the unwanted data and noise from the database are reduced using the Gabor filter, and the big databases are mapped and reduced using the Hadoop MapReduce (HMR) technique for improving the efficiency of the proposed GA-EHO. Furthermore, the feature selection using GA-EHO is processed on the filtered dataset. The implementation of the proposed system is done by using some machine learning classifiers for classifying the data and the efficiency is predicted for the proposed work. From the simulation results, the specificity, maximum accuracy, and sensitivity of the proposed GA-EHO are produced about 87.88%, 99.1%, and 81%. Also, the results are compared with other existing techniques.
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Rakshit, Soumyasanta, and Dr S. S. Sridhar. "Asset Management Security System Using RFID Technology." International Journal of Engineering & Technology 7, no. 4.6 (September 25, 2018): 391. http://dx.doi.org/10.14419/ijet.v7i4.6.28448.
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Using radio wave or radio frequency scanners to identify wirelessly any object is not so much complex in reality. The latest version of this technology is known as radio frequency identification or RFID. RFID has three building blocks: small tags built around microchips that carry a digital identification code; The RFID scanners also known as readers, the readers are also known as interrogators and networking hardware and the software to link scanners to the main computer databases that can be in hardware or cloud storage. In this project, we describe the implementation of RFID technology in the platform of asset management system in an organization. Using RFID technology track the all of the assets is the main aim of the project. The RFID interrogators open a serial port and then reads a RFID tag to use it as a unique parameter in the database to access and show the record associated to the RFID chip. Any change is wirelessly synchronized to the main database server.An admin will look after the whole server as an administration. If any new asset is introduced which is not in the main database, when the RFID scanner detects that the admin will get a notification message also in anyway if any asset will tamper by anything or anyone or if someone will try to steal any asset then again, the admin will get a notification message instantly.
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Kim, Minjee, Ki Hoon Park, and Young Bong Kim. "Identifying Active Compounds and Targets of Fritillariae thunbergii against Influenza-Associated Inflammation by Network Pharmacology Analysis and Molecular Docking." Molecules 25, no. 17 (August 25, 2020): 3853. http://dx.doi.org/10.3390/molecules25173853.
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Complications due to influenza are often associated with inflammation with excessive release of cytokines. The bulbs of Fritillariae thunbergii (FT) have been traditionally used to control airway inflammatory diseases, such as bronchitis and pneumonia. To elucidate active compounds, the targets, and underlying mechanisms of FT for the treatment of influenza-induced inflammation, systems biology was employed. Active compounds of FT were identified through the TCMSP database according to oral bioavailability (OB) and drug-likeness (DL) criteria. Other pharmacokinetic parameters, Caco-2 permeability (Caco-2), and drug half-life (HL) were also identified. Biological targets of FT were retrieved from DrugBank and STITCH databases, and target genes associated with influenza, lung, and spleen inflammation were collected from DisGeNET and NCBI databases. Compound-disease-target (C-D-T) networks were constructed and merged using Cytoscape. Target genes retrieved from the C-D-T network were further analyzed with GO enrichment and KEGG pathway analysis. In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation. We retrieved the binding affinity of each ligand-target, and found that PG and COX-1 showed the strongest binding affinity among four binding results using a molecular docking method. We identified the potential compounds and targets of FT against influenza and suggest that FT is an immunomodulatory therapy for influenza-associated inflammation.
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Reyad, Dada, Fawwaz Khalid Yassin, and Mohamed Bayoumy. "Brentuximab Vedotin in Pretreated Hodgkin Lymphoma Patients: A Systematic Review and Meta-Analysis." Blood 126, no. 23 (December 3, 2015): 3866. http://dx.doi.org/10.1182/blood.v126.23.3866.3866.
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Abstract Introduction : The outcome of Hodgkin lymphoma (HL) has improved over the past 20 years. However, the probability of relapse after response to initial treatment is currently approximately 10 to 15 percent for localized HL (i.e. stage I and II) and 20 to 40 percent for advanced stages (i.e. IIIB and IV), dependent on prognostic factors [1]. In young patients eligible for dose intensive chemotherapy, salvage chemotherapy with autologous stem cell transplantation (ASCT) is a frequently used therapy option and can be considered as standard [2, 3]. Patients who relapse following ASCT and those not eligible for myeloablative therapy are being treated with conventional chemotherapy or new novel agents such brentuximab vedotin (BV). Since approval of BV several study groups published the results of their experience in treating refractory/relapsed HL patients with BV. Patients and methods: The purpose of this study was to evaluate the impact of BV on outcome of patients with refractory and relapsed HL. In this systematic review we analyzed the published data on refractory / relapsed Hodgkin lymphoma patients who received BV as single agent. A systematic literature search was performed and included studies published from 1st January 2000 to 1st July 2015 in PubMed, electronic databases EMBASE (Dialog), Cochrane Library, DIMDI-Recherche and MEDPILOT. We used the key words brentuximab, brentuximab vedotein, adcetris, CD30 antibody and SGN-35. Recent conference abstracts from the American Society for Clinical Oncology (ASCO) (2012-2015) and American Society of Hematology (ASH) (2012-2014) were also included. Serial reports of 5 patients and more were included. If several publications from same author and group were published, the publications were re-scanned whether the reported patients' cohorts are the same. We included patients treated with BV pre- and post-transplantation as well as those not eligible for transplantation. Publications reporting about experience with BV in several diseases, e.g. T cell lymphoma and HL, underwent special analysis in order to extract only the HL data. Studies using BV in combination with radiation were disqualified for our analysis. Results: 51 out of 5369 screened records met the eligibility criteria. After exclusion of duplicates and serial reports with <5 patients total of 22 records (17 full articles and 5 abstracts) were included. Data of 903 patients treated with BV as salvage treatment was collected. The median age of the cohort was 31 year (range: 26-45). The patients received in median 4 lines (range: 1-9) of chemotherapy prior to BV. Median follow up was 16.1 months (range: 4.5-45.1). Most patients were heavily pretreated, 529/903 and 232/903 underwent high dose chemotherapy and autologous stem transplantation or received allogeneic stem transplantation prior of BV respectively. The response rate was 62.7% (range: 30-100%). The complete remission, partial remission, stable disease and progressive disease rates were 31.8%, 35.1%, 19.5% and 11.7% respectively. The one year progression free survival and estimated one year overall survival were 47.7% and 70% respectively. Conclusion: Significant number of the cohort received autologous and/or allogeneic stem cell transplantation prior BV. Response rate of 62.7% and complete remission rate of 31.8% are supporting results of the pivotal study [4] and establish the solid basis for using BV in heavily pretreated HL patients. Litreature: 1. Josting, A., et al., New prognostic score based on treatment outcome of patients with relapsed Hodgkin's lymphoma registered in the database of the German Hodgkin's lymphoma study group. J Clin Oncol, 2002. 20 (1): p. 221-30. 2. Sirohi, B., et al., Long-term outcome of autologous stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma. Ann Oncol, 2008. 19 (7): p. 1312-9. 3. Rancea, M., et al., High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma. Cochrane Database Syst Rev, 2013. 6: p. CD009411. 4. Younes, A., et al., Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. J Clin Oncol, 2012. 30 (18): p. 2183-9. Disclosures No relevant conflicts of interest to declare.
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Lobel, Alex, Pierre Royer, Christophe Martayan, Michael Laverick, Thibault Merle, Mathieu Van der Swaelmen, Peter van Hoof, Marc David, Herman Hensberge, and Emmanuel Thienpont. "The Belgian Repository of Fundamental Atomic Data and Stellar Spectra (BRASS)." Atoms 7, no. 4 (November 22, 2019): 105. http://dx.doi.org/10.3390/atoms7040105.
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Background: BRASS (Belgian Repository of Fundamental Atomic Data and Stellar Spectra) is an international networking project for the development of a new public database providing accurate fundamental atomic data of vital importance for stellar spectroscopic research. We present an overview of research results obtained in the past four years. Methods: The BRASS database offers atomic line data we thoroughly tested by comparing theoretical and observed stellar spectra. We perform extensive quality assessments of selected atomic input data using advanced radiative transfer spectrum synthesis calculations, which we compare to high-resolution Mercator-HERMES and ESO-VLT-UVES spectra of F-, G-, and K-type benchmark stars observed with very high signal-to-noise ratios. We have retrieved about half a million atomic lines required for our detailed spectrum synthesis calculations from the literature and online databases such as VAMDC, NIST, VALD, CHIANTI, Spectr-W 3 , TIPbase, TOPbase, SpectroWeb. Results: The atomic datasets have been cross-matched based on line electronic configuration information and organized in a new online repository called BRASS. The validated atomic data, combined with the observed and theoretical spectra are also interactively offered in BRASS. The combination of these datasets is a novel approach for its development providing a universal reference for advanced stellar spectroscopic research. Conclusion: We present an overview of the BRASS Data Interface developments allowing online user interaction for the combined spectrum and atomic data display, line identification, atomic data accuracy assessments including line log(gf)-values, and line equivalent width measurements.
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Laranjo, Liliana, Amaël Arguel, Ana L. Neves, Aideen M. Gallagher, Ruth Kaplan, Nathan Mortimer, Guilherme A. Mendes, and Annie Y. S. Lau. "The influence of social networking sites on health behavior change: a systematic review and meta-analysis." Journal of the American Medical Informatics Association 22, no. 1 (July 8, 2014): 243–56. http://dx.doi.org/10.1136/amiajnl-2014-002841.
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Abstract Objective Our aim was to evaluate the use and effectiveness of interventions using social networking sites (SNSs) to change health behaviors. Materials and methods Five databases were scanned using a predefined search strategy. Studies were included if they focused on patients/consumers, involved an SNS intervention, had an outcome related to health behavior change, and were prospective. Studies were screened by independent investigators, and assessed using Cochrane's ‘risk of bias’ tool. Randomized controlled trials were pooled in a meta-analysis. Results The database search retrieved 4656 citations; 12 studies (7411 participants) met the inclusion criteria. Facebook was the most utilized SNS, followed by health-specific SNSs, and Twitter. Eight randomized controlled trials were combined in a meta-analysis. A positive effect of SNS interventions on health behavior outcomes was found (Hedges’ g 0.24; 95% CI 0.04 to 0.43). There was considerable heterogeneity (I2 = 84.0%; T2 = 0.058) and no evidence of publication bias. Discussion To the best of our knowledge, this is the first meta-analysis evaluating the effectiveness of SNS interventions in changing health-related behaviors. Most studies evaluated multi-component interventions, posing problems in isolating the specific effect of the SNS. Health behavior change theories were seldom mentioned in the included articles, but two particularly innovative studies used ‘network alteration’, showing a positive effect. Overall, SNS interventions appeared to be effective in promoting changes in health-related behaviors, and further research regarding the application of these promising tools is warranted. Conclusions Our study showed a positive effect of SNS interventions on health behavior-related outcomes, but there was considerable heterogeneity. Protocol registration The protocol for this systematic review is registered at http://www.crd.york.ac.uk/PROSPERO with the number CRD42013004140.
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Suryono, Ryan Randy. "FINANCIAL TECHNOLOGY (FINTECH) DALAM PERSPEKTIF AKSIOLOGI." Masyarakat Telematika Dan Informasi : Jurnal Penelitian Teknologi Informasi dan Komunikasi 10, no. 1 (September 25, 2019): 52. http://dx.doi.org/10.17933/mti.v10i1.138.
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A technology is generated from the development of science which is then implemented in society. Changes in science to technology are inseparable from scientists. A scientist will be confronted with personal interests or interests of the general public which bring to the issue of scientific ethics and value-free problems. Likewise with the progress of e-finance and mobile technology for financial companies. This prompted Fintech's innovation to emerge after the global financial crisis in 2008 by combining e-finance, internet technology, social networking services, social media, artificial intelligence, and Big Data analytics. In addition, with the development of the digital economy, Fintech is present as an innovation. But in its development, there are still positive and negative issues from the application of Fintech that provide many new perspectives that lead to moral and ethical issues. By adopting the Kitchenham Systematic Literature Review (SLR) approach, this study identifies what problems occur in the development of Fintech. Using three databases, including SCOPUS, ScienceDirect, and IEEE Xplore and Mendeley devices for journal database management, this study attempts to formulate an understanding of Fintech, Fintech variety, trends and Fintech innovations, what problems arise from Fintech innovation and how solutions are implemented Fintech
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Patano, Assunta, Nunzio Cirulli, Matteo Beretta, Paola Plantamura, Alessio Danilo Inchingolo, Angelo Michele Inchingolo, Ioana Roxana Bordea, et al. "Education Technology in Orthodontics and Paediatric Dentistry during the COVID-19 Pandemic: A Systematic Review." International Journal of Environmental Research and Public Health 18, no. 11 (June 4, 2021): 6056. http://dx.doi.org/10.3390/ijerph18116056.
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Over the last decade, medical education changed from traditional teaching methods to telematic and networking scholar and e-learning approach. The objective of the present systematic review was to evaluate the effectiveness and teachers/student’s acceptability of e-learning applied to the field of orthodontics and paediatric dentistry. A database search of the literature was conducted on PubMed and Embase databases from January 2005 to May 2021. A total of 172 articles were identified by the electronic search, while a total of 32 papers were selected for qualitative analysis. Overall, 19 articles investigated the effectiveness of e-learning, and no difference of acceptability was reported between e-learning and traditional methods for a wide part of the articles selected. A total of 25 papers provided a satisfaction questionnaire for learners and all were positive in their attitude towards e-learning. The results showed that e-learning is an effective method of instruction, complementing the traditional teaching methods, and learners had a positive attitude and perception. The evidence of the present study reported a high level of acceptability and knowledge level of e-learning techniques, compared to frontal lecture methods, in the fields of orthodontics and paediatric dentistry.
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Gong, Leiguang, and Casimir A. Kulikowski. "Medical Image Processing in an Era of High-Performance Computing." Yearbook of Medical Informatics 03, no. 01 (August 1994): 61–68. http://dx.doi.org/10.1055/s-0038-1637994.
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AbstractAdvanced radiology practices are already benefiting from powerful and increasingly more economical computing and networking facilities. Medical image processing methods have improved dramatically over the past five years, with sophisticated 3D display, visualization and analysis techniques allowing increased integration of multiple modalities of imaging, flexible environments for imaging analysis, and P ACS (picture archiving and communication systems) for ease of transmission and retrieval. Emerging directions involve teleradiology and telesurgery virtual reality applications, the development of new image database techniques, and the building of large visual databases like that of the Visible Human Project. Challenging problems of image segmentation, registration, and multimodal image fusion are still with us. Building dynamic, flexible electronic atlases will have a profound effect on the understanding of structure and function from the level of cellular physiology to gross anatomy, but requires the development of new techniques of visual knowledge representation and more standardized ways of defining the conceptual and linguistic constructs of visual objects in biomedicine, for linkage to medical records, research results, and educational materials. Methods for reasoning with visual information in the context of multimedia information systems present an inviting challenge to the upcoming generation of researchers in medical informatics.
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Motokawa, Masaharu, Haruyoshi Gotoh, Shunsuke Yamashita, Hidetoshi Nagamasu, and Terufumi Ohno. "Connecting Museum Collections and Research as Scientific Infrastructure." International Journal of Humanities and Arts Computing 8, supplement (March 2014): 84–94. http://dx.doi.org/10.3366/ijhac.2014.0100.
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University museums are considered centers of object-based research. In object-based research, two interactive cycles connect collections and research during the production of new scientific results. To achieve good circulation of these two interactive cycles, connections between collection items and research publications are indispensable. However, these connections are currently made on a voluntary basis by each university museum. We expect that the establishment of a two-way connection system between collections and research will serve a new scientific infrastructure and worldwide framework. We propose the conceptual design of the ‘Connections between Collections and Research’ (CCR) database that might be linked with research publication and museum collection databases. Connections between research and collections will contribute to scientific clarity and visibility, support collection management, and promote disciplinary and interdisciplinary science based on each collection. Cooperation and networking by university museums, as well as by institutes and scientists that maintain and utilize collections is required in order to realize the development of this scientific infrastructure. By reflecting the resources of university collections and scientists in various research fields, including information science, university museums worldwide might make significant contributions to the establishment and organization of a new system that aims to connect collections and research.
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S. Bhatt, Malay, and Tejas P. Patalia. "Indian Monuments Classification using Support Vector Machine." International Journal of Electrical and Computer Engineering (IJECE) 7, no. 4 (August 1, 2017): 1952. http://dx.doi.org/10.11591/ijece.v7i4.pp1952-1963.
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Recently, Content-Based Image Retrieval is a widely popular and efficient searching and indexing approach used by knowledge seekers. Use of images by e-commerce sites, by product and by service industries is not new nowadays. Travel and tourism are the largest service industries in India. Every year people visit tourist places and upload pictures of their visit on social networking sites or share via the mobile device with friends and relatives. Classification of the monuments is helpful to hoteliers for the development of a new hotel with state of the art amenities, to travel service providers, to restaurant owners, to government agencies for security, etc.. The proposed system had extracted features and classified the Indian monuments visited by the tourists based on the linear Support Vector Machine (SVM). The proposed system was divided into 3 main phases: preprocessing, feature vector creation and classification. The extracted features are based on Local Binary Pattern, Histogram, Co-occurrence Matrix and Canny Edge Detection methods. Once the feature vector had been constructed, classification was performed using Linear SVM. The Database of 10 popular Indian monuments was generated with 50 images for each class. The proposed system is implemented in MATLAB and achieves very high accuracy. The proposed system was also tested on other popular benchmark databases.
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Duha Khalid Abdul-Rahman Al-Malah, Ban Hassan Majeed, and Haider TH Salim ALRikabi. "Enhancement the Educational Technology by Using 5G Networks." International Journal of Emerging Technologies in Learning (iJET) 18, no. 01 (January 10, 2023): 137–51. http://dx.doi.org/10.3991/ijet.v18i01.36001.
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With the spread of global markets for modern technical education and the diversity of programs for the requirements of the local and global market for information and communication technology, the universities began to race among themselves to earn their academic reputation. In addition, they want to enhance their technological development by developing IMT systems with integrated technology as the security and fastest response with the speed of providing the required service and sure information and linking it The network and using social networking programs with wireless networks which in turn is a driver of the emerging economies of technical education. All of these facilities opened the way to expand the number of students and solve the problem of accumulation, collection and analysis of data by storing it with large, expanded and automatically interconnected databases between university places and departments to provide services adapted to the desire of demand. This research dealt with a sample from of the academic’s opinions and students. The sample is 319 questionnaires. It concluded that each of the infrastructure, devices, Internet of things, smart classrooms, and administrative database, with the presence of the fifth-generation network and its equipment, have a statistically significant correlation with technical education technology.
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Sharp, Elliott W., Keegan Curlewis, and Thomas H. S. Clarke. "Stop paying through the nose: student and trainee medical conferences offer better value for money than professional alternatives." Postgraduate Medical Journal 95, no. 1129 (July 24, 2019): 577–82. http://dx.doi.org/10.1136/postgradmedj-2019-136734.
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BackgroundScientific conferences in the UK are attended by practising doctors and medical students for sharing research, networking and professional development. Student/trainee conferences are typically cheaper than professional conferences, but as they are not acknowledged in national scoring systems for medical and surgical training applications, they may have worse attendance than otherwise possible. We questioned whether student/trainee conferences are of a similar scientific quality to professional conferences, while being considerably cheaper.MethodsIn this cross-sectional database review, 162 conferences were identified through a systematic search of two conference databases by three independent researchers. χ2 tests were used to compare scientific quality between student/trainee and professional conferences and the likelihood of offering different types of discounts. Independent t-tests were employed to determine cost differences between the two categories of conferences.ResultsOur data revealed that there was no significant difference between student/trainee and professional conferences likelihood of declaring information on their abstract review processes (p=0.105). There was no difference in speaker seniority, determined by the tool the authors developed (p=0.172). Student/trainee conferences were significantly more likely to offer workshops (p<0.0005) and were cheaper than professional conferences (p<0.0005).ConclusionOur results show that student/trainee conferences offer a similar level of scientific quality to professional medical conferences in the UK at a fraction of the cost, which should be reflected within the national scoring systems.
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Magalhães, Jorge, Henrique Koch Chaves, and Viviane Theodora Muniz. "AN OVERVIEW OF BIG DATA IN COVID-19 AS A CONTRIBUTION TO THE MANAGEMENT OF SCIENTIFIC AND TECHNOLOGICAL KNOWLEDGE." Problems of Management in the 21st Century 16, no. 2 (December 15, 2021): 102–11. http://dx.doi.org/10.33225/pmc/21.16.102.
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In times of pandemic, rapid sharing of research data is urgently needed, as is the intensification of networking. The COVID-19 pandemic brought a new perspective in relation to knowledge management in various organizational means, whether through the search for innovation or the improvement of its processes. Thus, to calculate the state of the art and track scientific and technological knowledge in the COVID-19 spectrum, the keyword “Coronavir*” was used in the PubMed and Espacenet databases. Data were processed by Carrot Search Lingo4G® and PatentInspiration®. In the Pubmed database, 1,000 documents were retrieved, which were organized into 81 groups of sub-themes, with emphasis on the sub-theme “treatment during coronavirus disease”, with 188 articles (18.8% of the total). Regarding technological innovation, China and the United States were the countries that filed the most patent applications, especially in 2020 and 2021, corresponding to 68.5% of the total. The first 4 (four) applicants with the highest number of patents were Pfizer, Gilead Sciences Inc., Center Nat Rech, Crucell Holland. The results obtained over a period of time demonstrate a partnership between universities and companies towards the fight against the pandemic. The tools for identifying, extracting and processing data (or free), are needed efficiently in the management of scientific and technological knowledge in COVID -19, thus being able to contribute to more assertive decision-making at various organizational levels. Keywords: Big Data, COVID-19, Knowledge Management, coronavirus patents
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Mamatha, S., and T. Sudha. "A Survey on Big Data Analytics Using HADOOP." Asian Journal of Computer Science and Technology 8, S3 (June 5, 2019): 35–40. http://dx.doi.org/10.51983/ajcst-2019.8.s3.2091.
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In this digital world, as organizations are evolving rapidly with data centric asset the explosion of data and size of the databases have been growing exponentially. Data is generated from different sources like business processes, transactions, social networking sites, web servers, etc. and remains in structured as well as unstructured form. The term ― Big data is used for large data sets whose size is beyond the ability of commonly used software tools to capture, manage, and process the data within a tolerable elapsed time. Big data varies in size ranging from a few dozen terabytes to many petabytes of data in a single data set. Difficulties include capture, storage, search, sharing, analytics and visualizing. Big data is available in structured, unstructured and semi-structured data format. Relational database fails to store this multi-structured data. Apache Hadoop is efficient, robust, reliable and scalable framework to store, process, transforms and extracts big data. Hadoop framework is open source and fee software which is available at Apache Software Foundation. In this paper we will present Hadoop, HDFS, Map Reduce and c-means big data algorithm to minimize efforts of big data analysis using Map Reduce code. The objective of this paper is to summarize the state-of-the-art efforts in clinical big data analytics and highlight what might be needed to enhance the outcomes of clinical big data analytics tools and related fields.
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Reyes-Menendez, Ana, Jose Ramon Saura, and Ferrão Filipe. "The importance of behavioral data to identify online fake reviews for tourism businesses: a systematic review." PeerJ Computer Science 5 (September 23, 2019): e219. http://dx.doi.org/10.7717/peerj-cs.219.
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In the last several decades, electronic word of mouth (eWOM) has been widely used by consumers on different digital platforms to gather feedback about products and services from previous customer behavior. However, this useful information is getting blurred by fake reviews—i.e., reviews that were created artificially and are thus not representative of real customer opinions. The present study aims to thoroughly investigate the phenomenon of fake online reviews in the tourism sector on social networking and online reviews sites. To this end, we conducted a systematic review of the literature on fake reviews for tourism businesses. Our focus was on previous studies that addressed the following two main topics: (i) tourism (ii) fake reviews. Scientific databases were used to collect relevant literature. The search terms “tourism” and “fake reviews” were applied. The database of Web of Science produced a total of 124 articles and, after the application of different filters following the PRISMA 2009 Flow diagram, the process resulted in the selection of 17 studies. Our results demonstrate that (i) the analysis of fake reviews is interdisciplinary, ranging from Computer Science to Business and Management, (ii) the methods are based on algorithms and sentiment analysis, while other methodologies are rarely used; and (iii) the current and future state of fraudulent detection is based on emotional approaches, semantic analysis and new technologies such as Blockchain. This study also provides helpful strategies to counteract the ubiquity of fake reviews for tourism businesses.
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Sullivan, Jill, Jamie Jackson, Griffen Kristie, John Eberly, Jennifer Davis, Suzanne R. Fanning, and Hal E. Crosswell. "Clinical Trial Enrolment In the Adolescent and Young Adult (AYA) Population with Hematologic Malignancies: A South Carolina (SC) Community Practice Perspective." Blood 116, no. 21 (November 19, 2010): 2577. http://dx.doi.org/10.1182/blood.v116.21.2577.2577.
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Abstract Abstract 2577 Background: Leukemias and lymphomas comprise 25% of all cancers in AYA patients age 15–39 years. Survival benefit from treatment advances has been less for AYA patients compared to the pediatric patients (<15 years of age). One reason for this disparity in survival is the relative lack of clinical trial accrual in AYA population. Previous population-based analysis of cooperative group participation between 1992 and 1997 found 71% of children under age 15 participated in clinical trials versus 24% of 15–19 year olds and less than 2% of 20–29 year olds (Liu et al., 2003). The majority of reports on this “AYA Gap” have been from large academic institutions or pooled national databases. We report our 5 year experience of clinical trial enrolment of AYA leukemias and lymphomas (L&L) from a SC community-based practice. Methods: We retrospectively analyzed the data on all patients, age 0–39 years, with newly diagnosed acute leukemias(ALL, AML) and lymphomas (Hodgkin {HL} and non-hodgkin lymphoma{NHL}) between 2005 and 2009 through the Greenville Memorial Hospital (GMH) and BI-LO Charities Children's Cancer Center (BCCCC) registries in Greenville SC. AYA was defined ages 15–39, with the pediatric ages <15 as the control. Demographic comparisons were made with available state-wide and SEER registry data. Clinical trial availability was abstracted from practice clinical research offices and NCI database using www.clinicaltrials.gov. Results: Among 684 total oncology patients 0–39 years of age, 528 were AYA. Median age was 33 for the total AYA population but 26 for the 76 patients with L&L (ALL = 14, AML = 7, HL = 27, NHL = 28); there was no difference between the pediatric and AYA populations in regards to other demographic characteristics (race, gender, insurance, or vital status). Leukemia and lymphoma patients age 15–39 represented a similar distribution (4.7% and 10.4% of total diagnosis, respectively) in comparison to statewide and SEER data. Leukemia accounted for 80% of pediatric diagnoses while lymphoma comprised the bulk (72%) of AYA diagnoses; this is similar to data observed nationally. Statewide clinical trials were available to 72% of pediatric patients and 60% of AYA patients; local clinical trial availability was higher in the pediatric population than the AYA population (94% versus 69%). Sixty-two percent of pediatric patients were actually enrolled on a clinical trial in comparison to only 17% of AYA patients. Only 21% of AYA were treated at a pediatric facility, as compared to 98% of pediatric patients. Clinical trial enrollment of AYA patients treated at a pediatric facility was 75% versus 3% of patients treated at an adult facility. For the 97% of AYA patients treated at an adult facility but not enrolled on a clinical trial, 55% of patients had a trial available to them locally (34%) or statewide (21%). When considering lymphoma alone, as the most prominent AYA diagnosis, the majority of HL (89%) and NHL (82%) patients were not enrolled on clinical trials; of those patients not enrolled on a clinical trial, only 30% and 22% of HL and NHL, respectively, had a clinical trial available to them locally. Conclusion: In a community-based adult and pediatric oncology practice, there is a significant discrepancy in the number of L&L patients enrolled on a clinical trial when comparing pediatric and AYA cohorts. AYA L&L patients fail to be enrolled on clinical trials due to lack of clinical trial availability as compared to the pediatric L&L population. Disclosures: No relevant conflicts of interest to declare.
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Avery, Joshua M. "The Open Access Availability of Articles from Highly Ranked Religious Studies Journals." Theological Librarianship 11, no. 1 (April 5, 2018): 12–17. http://dx.doi.org/10.31046/tl.v11i1.465.
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Across the past decade, open access (OA) journal scholarship has seen a massive global increase. Scant research, however, has been done to examine the effect of this trend on religious studies journal scholarship. This article seeks to explore the current state of OA scholarship among journals covering religion. To examine the state of OA scholarship among journals of religious studies, the OA availability of articles from ten, peer-reviewed, religious studies journals were examined. Using the SCImago Journal & Country Rank, a portal that includes the journals and country scientific indicators developed from the information contained in the Scopus® database, the ten most highly rated journals in mid-2015, according to the SJR indicator, were selected for evaluation. Articles that appeared in the journal volumes published in 2014 were selected for analysis, and were identified through online research databases and journal websites which provided bibliographic information. Only articles and essays dealing with research were included. A total of 377 articles were included in the study. Of the 377 articles examined, OA versions were found for 132 (35%) of them. Approximately one third of articles (33.3%) were located in multiple locations, with more than half of all OA articles found (53.0%) on either Institutional or Subject repositories, or, on the social networking sites ResearchGate.net or Academia.edu. Of the total number of OA articles found, 87 (65.9%) were found by both Google and Google Scholar, and 43 (32.6%) were found by only Google or Google Scholar, but not both. The results indicate that religious studies journal scholarship is not widely archived and made available as OA, as a regular practice. Results also indicate that those scholars who publish in journals covering religious studies and who embrace open access, make strong use of either institutional or subject repositories and/or social networking sites to make their scholarship openly available. The relatively low rate of OA religious studies journal scholarship, has limited support in previous literature. While the results of this study indicate an increase in the OA availability of religious studies journal scholarship, as compared to previous findings, scholars and journals of religion still lag behind other disciplines in the output of OA research.
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Abdulla, Aziz. "Friends of Open Access." TJES Vol.27 No.3 (2020) 27, no. 3 (September 1, 2020): 1–7. http://dx.doi.org/10.25130/tjes.27.3.pb1.
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Abstract Peace, mercy, and blessings of God be upon you https://scholarlyoa.net I looked at the site above, and on the allegations, he makes against Beall Jeffrey I would like to clarify the following 1-It seems that the site is not official, and those who are responsible for it are unknown and they call themselves Friends of Open Access or a group of librarians did not say, publishers or university professors, they did not mention any name or institution sponsoring the site. 2-I read most of their claims about Beall Jaffrey’s criteria, and it is incorrect. The criteria of Beall Jeffrey consist of about 40 items, and all of them are logical. And through it, the predatory journal is published quickly, without evaluation, and without classifying the article in international databases. 3-It focuses on the standard of publishing fees only, which is one of the criteria and does not mean that every journal that asks for fees is a predatory journal. 4-The site uses the same name as the Beall list but has a .net extension instead of .com, It violates publishing ethics and exploits the reputation of the well-known and well-known website. 5-Below are the links to Beall Jeffrey scientific pages, which shows the credibility of his articles published in reputable international journals. He has more than 1000 citations in the Scopus database and more than 3000 total citations in all journals –https://scholar.google.com.my/citations?hl=ar&user=EtHsEcMAAAAJ –https://www.scopus.com/authid/detail.uri?authorId=8869689200 6-Beall’s main website was suspended in 2017, there are many websites now that rely on Beall Jeffrey’s criteria, but most of them are unofficial, and it may demand sums from journals to be removed from the list. 7-This site claims the existence of lawsuits against Bell Jefri and does not provide any evidence for that.
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Henderson, Tara O., Sharon M. Castellino, Frank G. Keller, Kara M. Kelly, Rachael Curtis, Rena M. Conti, and Susan K. Parsons. "Approach and Feasibility of Patient-Reported Outcomes (PROs) in a Phase III Clinical Trial for Advanced Stage Classical Hodgkin Lymphoma (cHL) in Children and Adolescents." Blood 128, no. 22 (December 2, 2016): 3583. http://dx.doi.org/10.1182/blood.v128.22.3583.3583.
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Abstract Introduction: Given the high cure rates in classical Hodgkin lymphoma (cHL) with conventional therapy, careful consideration of the economics of newer agents should be considered. We describe the feasibility of embedding Patient-Reported Outcomes (PROs) for chemotherapy-induced peripheral neuropathy (CIPN) and cost effectiveness (CEA) in a randomized, multi-institutional Phase III study [NCT02166463; Children's Oncology Group (COG) AHOD1331], evaluating the efficacy of the novel agent, Brentuximab vedotin, for advanced cHL in children and adolescents. Methods: Recruitment for PROs of interest is targeted for 250 of the planned 600 trial participants. Participation in the trial includes prospective collection of patient- and parent proxy-reported outcomes. CIPN is evaluated with the 11-item FACT-GOG-NTX and paired with the 9-item CHRIs-Global to serially evaluate health-related quality of life (HRQL) consequences of CIPN from initial diagnosis to 12 months off therapy. For CEA, US-based participants are queried from diagnosis through 36 months off therapy with the 4-item Stanford Healthcare Utilization Questionnaire (parent-report), the Health Utilities Index (HUI) 2/3, and the 23-item Caregiver Work Limitations Questionnaire (parent-report) as a measure of productivity loss. A study-designated research assistant is charged with contacting site personnel at study entry and at each scheduled assessment. All data are uploaded into a web-based relational database for future analysis. Units of healthcare utilization from the Stanford Healthcare Utilization measure and adverse events (AE) requiring hospitalization will be monetized with unit costs from US-based administrative databases, including the US National Inpatient Sample (NIS) and Kids' Inpatient Database (KID), Massachusetts All-Payer Claims Database (APCD) and Medicare, based on site of care and diagnostic and/or procedure codes. Data on severe AE from the two predecessor trials (COG AHOD 0031 and AHOD 0831) will be monetized as a training exercise. Total costs will be calculated by study arm and will include monetization of significant adverse events and health care utilization and will be expressed as cost per quality-adjusted life year derived from the HUI. Results: The clinical trial, activated in March 2015, has enrolled 161 participants; accrual is ongoing at 172 participating institutions. 156 participants (>95%) have completed the baseline CIPN and CEA measures. Among participants who have completed the baseline CIPN and CEA assessments, 90% have completed subsequent measures. Monetization of significant adverse events and utilization is in progress. Conclusion: We demonstrate a feasible approach evidenced by high completion rates of assessments for prospective evaluation of CIPN, HRQL, and healthcare utilization in a multi-institutional trial of children with advanced HL. Our experience serves as a proof of principle to cooperative groups regarding the resources and the feasibility of incorporating necessary PRO and health utilization outcomes into Phase III clinical trials as a component of cancer care delivery research. Disclosures Henderson: Seattle Genetics: Research Funding.
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Estabrooks, Paul, LaKaija Johnson, Jolene Rohde, Carol Geary, Lani Zimmerman, Matthew Rizzo, and Mary Cramer. "3369 Assessment to Action: Engaging network member’s in identifying needs and directions of network improvement." Journal of Clinical and Translational Science 3, s1 (March 2019): 130. http://dx.doi.org/10.1017/cts.2019.296.
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OBJECTIVES/SPECIFIC AIMS: To complete a needs assessment and action planning process that engaged clinical and translational research network members in identifying needs through survey feedback, characterizing the needs in small group sessions, and developing recommendations for action at the network’s annual scientific meeting. METHODS/STUDY POPULATION: The project included (1) a survey of 357 members across partner institutions from the Great Plains IDeA CTR Network, (2) 6 - 90 minute brainstorming sessions to characterize needs identified through survey assessment, and (3) 6 - 60 minute sessions to develop recommendations for network improvement based on the characterization activity. Approximately 75 members participated in the characterization and recommendation sessions. RESULTS/ANTICIPATED RESULTS: Seven areas of need from the survey were identified based upon the frequency of identification by network members (support to move research across the translational spectrum, database design and management, data access and sharing, data analysis, recruitment and retention of subjects, support for members who have submitted grants but were repeatedly unsuccessful, mentoring). Members indicated which characterization sessions they were interested in attending and based on the enrollment numbers needs related to unsuccessful grant submitters and mentoring were combined as were needs related to database design and data access-sharing. Sessions resulted in 8 inter-related recommendations for network action that included to (1) develop GP-CTR directory/registry of clinicians, researchers, system partners, that can be used to identify people that want to be involved in research partnerships or mentoring, (2) create a GP CTR Navigators Program to will provide support to network members throughout the collaborative research and grant preparation process, (3) identify and disseminate information about assets (funding, databases/registries) that exist amongst network partners that can be leveraged by member, (4) develop a searchable repository of evidence-based interventions for T3/T4 efforts, (5) review GP CTR supported professional development, and technological resource offerings and identify potential gaps, (6) facilitate opportunities for peer support/networking, (7) provide guidance to GP CTR network institutions looking to adopt policies that will support translational research collaboration, and (8) identify potential barriers to GP CTR network engagement (i.e., infrastructure, communication, marketing). DISCUSSION/SIGNIFICANCE OF IMPACT: This process allowed for a wide range of network members to contribute to actionable recommendations for CTR leadership to move into action and improve the scientific network’s ability to conduct clinical and translational research.
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Wang, Yuan, Evgenia Glukhov, Yifan He, Yayue Liu, Longjian Zhou, Xiaoxiang Ma, Xueqiong Hu, Pengzhi Hong, William H. Gerwick, and Yi Zhang. "Secondary Metabolite Variation and Bioactivities of Two Marine Aspergillus Strains in Static Co-Culture Investigated by Molecular Network Analysis and Multiple Database Mining Based on LC-PDA-MS/MS." Antibiotics 11, no. 4 (April 12, 2022): 513. http://dx.doi.org/10.3390/antibiotics11040513.
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Co-culture is known as an efficient way to explore the metabolic potential of fungal strains for new antibiotics and other therapeutic agents that could counter emerging health issues. To study the effect of co-culture on the secondary metabolites and bioactivities of two marine strains, Aspergillus terreus C23-3 and Aspergillus. unguis DLEP2008001, they were co-cultured in live or inactivated forms successively or simultaneously. The mycelial morphology and high-performance thin layer chromatography (HPTLC) including bioautography of the fermentation extracts were recorded. Furthermore, the agar cup-plate method was used to compare the antimicrobial activity of the extracts. Based on the above, liquid chromatography-photodiode array-tandem mass spectrometry (LC-PDA-MS/MS) together with Global Natural Products Social molecular networking (GNPS) and multiple natural products database mining were used to further analyze their secondary metabolite variations. The comprehensive results showed the following trends: (1) The strain first inoculated will strongly inhibit the growth and metabolism of the latter inoculated one; (2) Autoclaved A. unguis exerted a strong inducing effect on later inoculated A. terreus, while the autoclaved A. terreus showed high stability of its metabolites and still potently suppressed the growth and metabolism of A. unguis; (3) When the two strains are inoculated simultaneously, they both grow and produce metabolites; however, the A. terreus seemed to be more strongly induced by live A. unguis and this inducing effect surpassed that of the autoclaved A. unguis. Under some of the conditions, the extracts showed higher antimicrobial activity than the axenic cultures. Totally, A. unguis was negative in response but potent in stimulating its rival while A. terreus had the opposite effect. Fifteen MS detectable and/or UV active peaks showed different yields in co-cultures vs. the corresponding axenic culture. GNPS analysis assisted by multiple natural products databases mining (PubChem, Dictionary of Natural Products, NPASS, etc.) gave reasonable annotations for some of these peaks, including antimicrobial compounds such as unguisin A, lovastatin, and nidulin. However, some of the peaks were correlated with antagonistic properties and remain as possible novel compounds without mass or UV matching hits from any database. It is intriguing that the two strains both synthesize chemical ‘weapons’ for antagonism, and that these are upregulated when needed in competitive co-culture environment. At the same time, compounds not useful in this antagonistic setting are downregulated in their expression. Some of the natural products produced during antagonism are unknown chlorinated metabolites and deserve further study for their antimicrobial properties. In summary, this study disclosed the different responses of two Aspergillus strains in co-culture, revealed their metabolic variation, and displayed new opportunities for antibiotic discovery.
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Marr, Kristin C., Jonathan Simkin, Andrea C. Lo, Joseph M. Connors, Alina S. Gerrie, Diego Villa, Ciara L. Freeman, et al. "Cardiac Morbidity in Adolescents and Young Adult Survivors of Hodgkin Lymphoma." Blood 136, Supplement 1 (November 5, 2020): 18–19. http://dx.doi.org/10.1182/blood-2020-136454.
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INTRODUCTION Adolescents and young adult (AYA) survivors of Hodgkin lymphoma (HL) are potentially at increased risk of cardiovascular (CV) disease due to anthracycline exposure, in addition to use of mediastinal radiotherapy (RT). Although the risk has been well described in the pediatric age-group, the impact in the AYA population has been less well characterized. Capturing the incidence of these late effects is challenging given that events can occur more than a decade after therapy completion. Using population-based administrative data, we evaluated the incidence of CV disease (combined heart failure (HF) and ischemic heart disease (IHD)) in a cohort of AYA survivors treated for classical HL (cHL) using ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) or equivalent chemotherapy. METHODS Patients with cHL aged 16-39 years (y), diagnosed between 1992-2013 and treated with an ABVD or equivalent therapy, were identified in the BC Cancer Lymphoid Cancer Database. Patients must have survived to an Index Date defined as 2 y from most recent HL event (primary diagnosis or if applicable, most recent relapse) and have had a minimum follow-up of 1 y beyond their Index Date. Patients were excluded if they had history of prior malignancy or HIV positivity. Limited stage disease was defined as stage IA, IB or IIA and absence of bulky disease (≥10cm); all others had advanced stage disease. Cases were linked with population-based databases of BC Cancer Registry; BC Radiation Oncology Database; and BC Ministry of Health (MOH) Chronic Disease Registry (CDR) that captures all BC residents registered with medical service plan coverage during the study period. The outcome variables, including HF and IHD, were defined by the BC MOH CDR using Standardized Case Definitions. To focus on late onset CV complications, only events that occurred after the Index Date were included in the analysis. A 10:1 individually-matched control population was identified from the CDR based on age, sex, and health authority region on the Index Date of the matched case. Controls were excluded if they had a pre-existing malignancy, HF, or IHD prior to the study window. Individual outcomes were collected from the Index Date of the matched case until December 31, 2015 or until an individual was censored due to loss to follow-up or death. Kaplan Meier (K-M) methodology and log-rank test was used to estimate cumulative incidence. A competing risk regression analysis was used to evaluate relative risk (RR) and p-values less than 0.05 were considered significant. RESULTS With a median follow-up time of 11 y (range 3-24 y) from most recent HL event, 764 AYA 2-y survivors were identified, aged 20 to 61 y (median 38 y) at the end of study period. The proportion of limited and advanced stage disease was 34.2% and 65.6%, respectively; and 49.9% were male. Eighty-eight patients (11.5%) had relapsed disease; eighty-six (11.3%) underwent high dose chemotherapy and autologous stem cell transplantation as part of their salvage therapy. In total, 268 patients (36.4%) were treated with mediastinal RT for primary therapy or for relapsed disease. Fifty-three percent received cumulative anthracycline dose ≥300 mg/m2. Survivors had a 3-fold increased risk of CV disease relative to controls (p<0.0001). The onset of CV disease in survivors occurred at median of 11.7 y after most recent treatment (range 2.2-19.2 y), and at a median age of 44.3 y (range 21 - 58 y). At 15 y, the estimated cumulative incidence of CV disease was 6.3% in survivors compared to 2.3% in controls (Figure A). In the 496 survivors that received chemotherapy only, the incidence of CV disease at 15 y was 4.6% vs 2.3% in controls, and those that received anthracyclines and mediastinal RT had significantly higher incidence at 8.6% (Figure B). The increase in risk was greatest for a diagnosis of HF (RR 6.92, p<0.0001): at 15 y, the cumulative incidence of HF was 2.2% vs 0.6% in controls. The RR of IHD was 2.63 (p<0.0001) with incidence of 5.1% in cases compared to 1.8% in controls. CONCLUSION Similar to the pediatric population, AYA cHL survivors are at increased risk of both HF and IHD after completion of treatment. The majority of patients had received ABVD alone and had a lower incidence of CV disease at 15 y when compared to those that received treatment that included mediastinal RT. These results will inform counseling regarding risk factor modification and aid in the development of surveillance guidelines for AYA survivors. Disclosures Gerrie: Sandoz: Consultancy; Roche: Research Funding; Janssen: Consultancy, Honoraria, Research Funding; AbbVie: Consultancy, Honoraria, Research Funding; Astrazeneca: Consultancy, Research Funding. Villa:Celgene: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Roche: Consultancy, Honoraria, Research Funding; AZ: Consultancy, Honoraria, Research Funding; Kite/Gilead: Consultancy, Honoraria; Nano String: Consultancy, Honoraria; Seattle Genetics: Consultancy, Honoraria; Sandoz Canada: Consultancy, Honoraria; Immunovaccine: Consultancy, Honoraria; Purdue Pharma: Consultancy, Honoraria. Scott:NIH: Consultancy, Other: Co-inventor on a patent related to the MCL35 assay filed at the National Institutes of Health, United States of America.; Roche/Genentech: Research Funding; Celgene: Consultancy; NanoString: Patents & Royalties: Named inventor on a patent licensed to NanoString, Research Funding; Abbvie: Consultancy; AstraZeneca: Consultancy; Janssen: Consultancy, Research Funding. Sehn:AstraZeneca: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Kite: Consultancy, Honoraria; Gilead: Consultancy, Honoraria; Karyopharm: Consultancy, Honoraria; Genentech, Inc.: Consultancy, Honoraria, Research Funding; Acerta: Consultancy, Honoraria; F. Hoffmann-La Roche Ltd: Consultancy, Honoraria, Research Funding; MorphoSys: Consultancy, Honoraria; Merck: Consultancy, Honoraria; Lundbeck: Consultancy, Honoraria; Seattle Genetics: Consultancy, Honoraria; Teva: Consultancy, Honoraria, Research Funding; Takeda: Consultancy, Honoraria; Servier: Consultancy, Honoraria; Amgen: Consultancy, Honoraria; AbbVie: Consultancy, Honoraria; Apobiologix: Consultancy, Honoraria; Verastem Oncology: Consultancy, Honoraria; TG therapeutics: Consultancy, Honoraria; Chugai: Consultancy, Honoraria. Savage:BeiGene: Other: Steering Committee; Roche (institutional): Research Funding; Merck, BMS, Seattle Genetics, Gilead, AstraZeneca, AbbVie, Servier: Consultancy; Merck, BMS, Seattle Genetics, Gilead, AstraZeneca, AbbVie: Honoraria.
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Wang, Shuai, Xinxin Yang, Wei Wang, Yunkun Zhang, Tianjiao Li, Lin Zhao, Yongrui Bao, and Xiansheng Meng. "Interpretation of the absorbed constituents and pharmacological effect of Spica Schizonepetae extract on non-small cell lung cancer." PLOS ONE 16, no. 3 (March 17, 2021): e0248700. http://dx.doi.org/10.1371/journal.pone.0248700.
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As a traditional Chinese medicine (TCM) with a usage history of over 2,000 years in China, Spica Schizonepetae possesses definite clinical activity in the treatment of non-small cell lung cancer (NSCLC). However, its active ingredients and mechanism of action remain unclear at present. The further exploration of its active components and underlying mechanism will provide a basis for the development of candidate anti-tumor drugs. Our previous study explored the chemical constituents of Spica Schizonepetae extract (SSE). On this basis, molecular networking technology was applied in analyzing the QTOF-MS/MS data of rat plasma after intragastric administration of SSE using the GNPS database platform. A total of 26 components were found, including 9 proterotype components and 17 metabolites, which revealed the potential active ingredients of SSE. Later, the Lewis lung cancer mouse model was established, and the inhibition rate and histopathological sections were used as the indicators to investigate the anti-tumor effect of SSE, whereas the body weight, survival rate, thymus index and spleen index served as the indicators to explore the pharmacological effects of SSE on improving mouse immunity. The results showed that SSE had comparable anti-tumor efficacy to cisplatin, which enhanced the immunity, improved the quality of life, and extended the survival time of lung cancer mice. Furthermore, human A549 lung tumor cells were selected to explore the mechanism of SSE in treating NSCLC based on cell metabonomics. After data mining by the MPP software, 23 differential endogenous metabolites were identified between SSE and tumor groups. Moreover, results of pathway enrichment analysis using the MetaboAnalyst 4.0 software indicated that these metabolites were mainly enriched in four metabolic pathways (p < 0.1). By adopting the network pharmacology method, the metabolic pathways discovered by cell metabolomics were verified against the ChEMBL, STITCH, UniProt and TCGA databases, and differences in the underlying mechanism between cells and humans were found. It was proved that SSE affected the metabolism of purine, arachidonic acid and histidine to exert the anti-tumor efficacy. Furthermore, the multi-target, multi-pathway, and immunoenhancement mechanism of SSE in anti-tumor treatment was revealed, which provided a scientific basis for new drug development and the rational application of Spica Schizonepetae in clinic.
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Szinay, Dorothy, Andy Jones, Tim Chadborn, Jamie Brown, and Felix Naughton. "Influences on the Uptake of and Engagement With Health and Well-Being Smartphone Apps: Systematic Review." Journal of Medical Internet Research 22, no. 5 (May 29, 2020): e17572. http://dx.doi.org/10.2196/17572.
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Background The public health impact of health and well-being digital interventions is dependent upon sufficient real-world uptake and engagement. Uptake is currently largely dependent on popularity indicators (eg, ranking and user ratings on app stores), which may not correspond with effectiveness, and rapid disengagement is common. Therefore, there is an urgent need to identify factors that influence uptake and engagement with health and well-being apps to inform new approaches that promote the effective use of such tools. Objective This review aimed to understand what is known about influences on the uptake of and engagement with health and well-being smartphone apps among adults. Methods We conducted a systematic review of quantitative, qualitative, and mixed methods studies. Studies conducted on adults were included if they focused on health and well-being smartphone apps reporting on uptake and engagement behavior. Studies identified through a systematic search in Medical Literature Analysis and Retrieval System Online, or MEDLARS Online (MEDLINE), EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsychINFO, Scopus, Cochrane library databases, DataBase systems and Logic Programming (DBLP), and Association for Computing Machinery (ACM) Digital library were screened, with a proportion screened independently by 2 authors. Data synthesis and interpretation were undertaken using a deductive iterative process. External validity checking was undertaken by an independent researcher. A narrative synthesis of the findings was structured around the components of the capability, opportunity, motivation, behavior change model and the theoretical domains framework (TDF). Results Of the 7640 identified studies, 41 were included in the review. Factors related to uptake (U), engagement (E), or both (B) were identified. Under capability, the main factors identified were app literacy skills (B), app awareness (U), available user guidance (B), health information (E), statistical information on progress (E), well-designed reminders (E), features to reduce cognitive load (E), and self-monitoring features (E). Availability at low cost (U), positive tone, and personalization (E) were identified as physical opportunity factors, whereas recommendations for health and well-being apps (U), embedded health professional support (E), and social networking (E) possibilities were social opportunity factors. Finally, the motivation factors included positive feedback (E), available rewards (E), goal setting (E), and the perceived utility of the app (E). Conclusions Across a wide range of populations and behaviors, 26 factors relating to capability, opportunity, and motivation appear to influence the uptake of and engagement with health and well-being smartphone apps. Our recommendations may help app developers, health app portal developers, and policy makers in the optimization of health and well-being apps.
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Hu, Yue, Liang Yang, Yunfei Lu, Yong Wang, Jianshuai Jiang, Yahui Liu, and Qing Cao. "Systems Network Pharmacology-Based Prediction and Analysis of Potential Targets and Pharmacological Mechanism of Actinidia chinensis Planch. Root Extract for Application in Hepatocellular Carcinoma." Evidence-Based Complementary and Alternative Medicine 2022 (September 20, 2022): 1–17. http://dx.doi.org/10.1155/2022/2116006.
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Purpose. Traditional Chinese medicine (TCM) sometimes plays a crucial role in advanced cancer treatment. Despite the significant therapeutic efficacy in hepatocellular carcinoma (HCC) that Actinidia chinensis Planch root extract (acRoots) has proven, its complex composition and underlying mechanism have not been fully elucidated. Therefore, this study analyzed the multiple chemical compounds in acRoots and their targets via network pharmacology and bioinformatics analysis, with the overarching goal of revealing the potential mechanisms of the anti-HCC effect. Methods. The main ingredients contained in acRoots were initially screened from the traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the candidate bioactive ingredient targets were identified using DrugBank and the UniProt public databases. Second, the biological processes of the targets of active molecules filtered from the ingredients of acRoots were evaluated using gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. Third, weighted gene coexpression network analysis (WGCNA) was performed to identify gene coexpression modules associated with HCC. The hub genes of acRoots in HCC were defined via contrasting the above module eigengenes with candidate target genes of acRoots. Furthermore, the target-pathway network was analyzed to explore the mechanism for anti-HCC effect of hub genes. Kaplan–Meier plotter database analysis was performed to validate the hub genes of acRoots correlation with prognostic values in HCC. In order to verify the results of the network pharmacological analysis, we performed a molecular docking approach on the active ingredients and key targets using the Discovery Studio software. The viability of SMMC-7721 and HL-7702 cells was determined by Cell counting kit-8 (CCK-8) after being treated with different concentrations of (+)-catechin (0, 50, 100, 150, 200, and 250 g/ml) for 24, 48, and 72 hours, respectively. Finally, qRT-PCR and Western blot involving human hepatocarcinoma cells were utilized to verify the impact of (+)-catechin on the hub genes associated with prognosis. Results. 6 out of 26 active ingredients extracted from TCMSP were deemed as the core ingredients of acRoots. 175 bioactive-ingredient targets of acRoots were obtained and a bioactive-ingredient targets network was established correspondingly. The biological processes (BP) of target genes mainly involved processes, such as toxic substance and wounding. The results of KEGG pathways indicated that the target genes were mainly enriched in pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, and other pathways. Also, the two hub genes (i.e., ESR1 and CAT) were closely associated with the prognosis of HCC patients. As a consequence, we predicated a series of signaling pathways, including estrogen signaling pathway and longevity regulation pathway, through which acRoots could facilitate the treatment for HCC. The molecular docking experiment ascertained that ESR1 and CAT had an effective binding force with (+)-catechin, one of the core ingredients of acRoots. Furthermore, (+)-catechin inhibited SMMC-7721 cell growth in a dose-dependent manner and a time-dependent manner. Finally, we suggest that the expression level of ESR1 and CAT is positively related to the (+)-catechin concentrations in in-vitro experiments. Conclusion. The bioactive ingredients of acRoots, including quercetin, (+)-catechin, beta-sitosterol, and aloe-emodin, have synergistic interactions in reinforcing the anticancer effect in HCC. Evidently, acRoots took effect by regulating multitargets and multipathways through its active ingredients. Further, (+)-catechin, the possible paramount anti-HCC active ingredient in acRoots, helped improve the prognosis of HCC patients by increasing the expression of ESR1 and CAT. Additionally, the findings yielded provide a conceptual guidance for the clinical treatment of HCC and the methods adopted are potentially applicable in the future comprehensive analysis of the underlying mechanisms of TCMs.
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Riaz, Irbaz, Rabbia Siddiqi, Umar Zahid, Urshila Durani, Kaneez Fatima, Qurat Ul Ain Riaz Sipra, Ammad Raina, et al. "Sex Differences in Faculty Rank and Leadership Positions Amongst Hematologists and Oncologists in United States: A Cross-Sectional Study." Blood 134, Supplement_1 (November 13, 2019): 3399. http://dx.doi.org/10.1182/blood-2019-130670.
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Introduction: We have previously reported underrepresentation of female faculty at senior academic ranks in hematology/oncology (H/O). In this analysis we aimed to investigate the influence of sex in attaining leadership positions amongst academic hematologists/oncologists in United States. Methods: Faculty members were identified at 146 H/O fellowship programs listed on fellowship and residency electronic interactive database (FREIDA.) Data was collected on demographics, academic rank and research output using Doximity and Scopus databases. We compared the unadjusted characteristics of men and women by using two-sided t-tests and χ2 tests where appropriate. In primary analysis, logistic regression models were used to evaluate sex differences on probability of having full professorship (versus assistant and associate professorship) and of achieving leadership positions including division chief, Program Director (PD) and Associate Program Director (APD). Adjusted models included the following variables: clinical experience in years, number of publications, h-index, appointment at top 20 hospital, clinical trial investigator status and National Institutes of Health funding. Stratified analysis was performed adjusting for duration of clinical experience (≤15 vs >15 years) Results: Fewer women were full Professors (21.9% vs 78.1%), division chiefs (16.7% vs 83.3%), and PDs (30.5% vs 69.5) but the number was similar for Associate Program Directors (47.1% vs 52.9%). In a univariate unadjusted model, women were less likely to be full professors compared to men (OR 0.39; 95% confidence interval [CI], 0.31-0.48; P<.001). However, in the multivariable adjusted model no statistically significant sex difference in full professorship was found (OR 1.05; 95% CI 0.71, 1.57; P=.85; Table). The likelihood of full professorship was positively associated with clinical experience in years, number of first/last author publications, h-index, and being a primary investigator on at least one clinical trial.In a univariate unadjusted model, women were less likely to be division chiefs as compared to males (OR 0.35; 95% CI, 0.16, 0.80; P=.01). However, in the multivariable adjusted model, there was no statistically significant sex difference in achieving the position of division chief (OR 0.57; 95% CI 0.20, 1.58; P=.28; Table). No significant difference was found between females and males for being program directors or associate program directors in both univariate and multivariate analysis. Similarly, a stratified analysis adjusting for duration of clinical experience (≤15 vs >15 years) found no significant sex differences in attaining leadership position (Table) Conclusion: We found that women are underrepresented at higher academic ranks and in leadership positions in hematology/oncology, but that sex is not a significant negative predictor to women obtaining leadership positions after correcting for traditional predictors of academic success. However, "non-traditional" and therefore less measurable and analyzable factors such as networking, mentorship, sponsorship, gender bias, balancing work and home responsibilities and many others may contribute and should be further investigated. Disclosures No relevant conflicts of interest to declare.
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Ayeni, Philips O., Blessed O. Agbaje, and Maria Tippler. "A Systematic Review of Library Services Provision in Response to COVID-19 Pandemic." Evidence Based Library and Information Practice 16, no. 3 (September 15, 2021): 67–104. http://dx.doi.org/10.18438/eblip29902.
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Objective – Libraries have had to temporarily shut their doors because of the COVID-19 pandemic, resulting in the provision of online and remote services. This review analyzed services offered by libraries, the technological tools used, and the challenges facing libraries during the pandemic. Methods – This study employed a systematic literature review, following the PRISMA checklist (Moher at al., 2009). The Building Blocks search strategy was employed to search for keywords of concepts in Library and Information Science Abstract (LISA), Library and Information Science Technology Abstract (LISTA), Library Science Database, Web of Science (WoS) core collections, and Google Scholar. A set of inclusion and exclusion criteria was pre-determined by the authors prior to database searching. Quality assessment of included studies was performed using the Mixed Methods Appraisal Tool (Hong et al., 2018). A tabular approach was used to provide a summary of each article allowing the synthesis of results, which led to the identification of eight broad categories of services provided by libraries in included studies. Results – The first set of searches from the 5 databases produced 3,499 results. After we removed duplicates and applied the inclusion and exclusion criteria based on titles and abstracts, 37 potentially relevant articles were identified. Further screening of the full-text led to the final inclusion of 23 articles used for the qualitative synthesis. The majority of the studies were conducted in the United States of America (n= 6, 26.1%), followed by India (n=4, 17%), and China (n=2, 8.7%). The remaining studies were carried out in United Kingdom, Ireland, Canada, Mexico, Romania, Czech Republic, Indonesia, Pakistan, Nigeria, Lesotho, and Zimbabwe. The most common method used in selected studies was the case study (n= 11, 48%), followed by survey (n=7, 30.4%), content analysis (n=4, 17.4%), and mixed methods (n=1, 4.3%). The majority of the studies were carried out in academic libraries (74%), while the rest were based on medical, public, and special libraries. Findings show that the majority of academic libraries in the included studies are providing and expanding access to electronic resources (n=16, 69.6%) and increasing open access resources and services (n=11, 47.8%). More so, most academic libraries are assisting in virtual education and teaching endeavors of faculty and students (n=13, 56.5%). In addition, some medical and public libraries are bolstering public health safety through health literacy (n=12, 52.2%), supporting research efforts, and engaging in virtual reference services, among others. In order to carry out these services, libraries are harnessing several educational, social networking, communication, and makerspaces technologies. Most of the libraries in the included studies reported budgetary challenges, and the need for new ICT infrastructure and Internet service as they move their services online. Conclusion – This review found that libraries are adapting in a number of ways to continue their roles in meeting patrons’ needs in spite of the growing challenges posed by COVID-19 restrictions and lockdown. For libraries to thrive in these trying times, there must be a well-structured approach to ensuring continuity of services. Libraries should prioritize the acquisition of electronic resources as well as increase their efforts to digitize resources that are only available in printed copies. As library services have predominantly shifted online, there should be concerted effort and support from government and funding agencies to equip libraries with the technological facilities needed to provide cutting-edge services. The quality assessment of the included studies shows that there is need for rigor and transparency in the methodological description of studies investigating library services provision in a pandemic. This review provides an overview of the ways libraries have responded to the challenges posed by a global pandemic, and hence will be of use and interest to all librarians especially those in health and academic sectors.
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Ramirez, Kelly. "Microbes matter: integrating microbial sequence information for biodiversity." Biodiversity Information Science and Standards 2 (May 18, 2018): e26009. http://dx.doi.org/10.3897/biss.2.26009.
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The large efforts to document and map aboveground biodiversity have helped to elucidate ecological and evolutionary mechanisms and processes, predict responses to global change, and identify potential management options in response to those changes. Yet these concepts have mostly been applied to aboveground plant and animal communities, while microbial diversity remains difficult to incorporate. The ability to integrate microbial sequence data into an accessible global infrastructure has previously been limited by a few key factors: First, most of microbial diversity remains undescribed and unknown; there is just an enormous amount of biodiversity. Second, there is a lack of congruence between the many disparate microbial datasets (e.g. taxonomy, phylogeny, and methodological biases), which limits the ability to monitor and quantify global patterns of the terrestrial microbiome. Finally, there is a lack of coordination and networking between scientists studying microbes. In this presentation I will discuss two case studies that highlight how we can begin to link microbial data to the already well-established macro-knowledge and other environmental databases (like global carbon maps) Study 1 – a megameta analysis: The emergence of high-throughput DNA sequencing methods provides unprecedented opportunities to further unravel microbial ecology and its worldwide role from human health to ecosystem functioning. However, in spite of the abundance of sequencing studies, combining data from multiple individual studies to address macroecological questions of bacterial diversity remains methodically challenging and plagued with biases. While previous meta-analysis efforts have focused on diversity measures or abundances of major taxa, in a recent study(1) we show that disparate amplicon sequence data can be combined at the taxonomy-based level to assess bacterial community structure. Using a machine learning approach, we found that rarer taxa are more important for structuring soil communities than abundant taxa. We concluded that combining data from independent studies can be used to explore novel patterns in bacterial communities, identify potential ‘indicator’ taxa with an important role in structuring communities, and propose new hypotheses on the factors that shape microbial biogeography previously overlooked. Study 2 – a global soil biodiversity database: Greater access to microbial data is an important next step for biodiversity research and conservation, and for understanding the ecology and evolution of microbial communities. In collaboration with the Global Soil Biodiversity Initiative and the German Biodiversity Synthesis Centre (sDIV) we outlined steps that must be taken to ensure microbial sequence data can be included in global measures and maps of biodiversity(2). Here I will discuss how the plant associated microbiome is an optimal starting point to synthesize microbial sequence data on an open and global platform. The plant-microbiome is an optimal model system that goes across scales and time, can act as a bridge between microorganisms and macroorganisms, and as an opportunity to more thoroughly explore the synthesis of global microbial sequence data (for a global soil biodiversity database). Beyond expanding primary research, the patterns discovered in a synthesis of plant-microbiome can be used to explore and guide ecosystem restoration and sustainability. Overall, a better understanding of microbial biodiversity will help to predict consequences of (human-induced) global changes and facilitate conservation and adaptation responses. (1) Ramirez, K.S., C.G. Knight et al. and F.T. de Vries (2017). Detecting macroecological patterns in bacterial communities across independent studies of global soils. Nature Microbiology. (2) Ramirez, K.S., M. Döring, N. Eisenhauer, C. Gardi, J. Ladau, J.W. Leff, G. Lentendu, Z. Lindo, M.C. Rillig, D. Russell, S. Scheu, M.G. St. John, F.T. de Vries, T. Wubet, W.H. van der Putten, D.H. Wall, (2015). Towards a global platform for linking soil biodiversity data. Frontiers in Ecology and Evolutionary Biology 3(91). doi: 10.3389/fevo.2015.00091
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Kim, Jung-Hyun, Christopher J. Hickey, and E. Y. Erin Ahn. "Aberrant Upregulation Of Alternatively Spliced Isoforms Of Son In Myeloid Leukemia: Implications In Hematopoiesis and Leukemogenesis." Blood 122, no. 21 (November 15, 2013): 3731. http://dx.doi.org/10.1182/blood.v122.21.3731.3731.
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Abstract SON is a large, poorly characterized nuclear speckle protein. The key structural domains comprising the SON protein are the serine/arginine-rich (RS) domain, single stranded RNA-, and double stranded RNA-binding domains, in addition to several long repeating amino acid sequences likely to facilitate its scaffolding function. Previously, we identified SON as a key factor for efficient RNA splicing of diverse genes related to cell cycle, DNA repair, and survival signaling pathways (Molecular Cell, 2011, 42:185). We also demonstrated that SON inhibits transcriptional activation of the promoter associated to the miR-23a-27a-24 cluster, which harbors a regulator for the expression of GATA-2, a known hematopoietic stem cell regulator (J. Biol. Chem. 2013, 288:5381). Moreover, SON is highly expressed in hematopoietic tissues/organs, and particularly upregulated in hematopoietic stem cells and leukemic blasts. These results suggest potential roles of SON in both normal hematopoiesis and hematological malignancies. Based on the nucleotide sequence of the SON gene, several databases predict that the primary transcript of SON contains alternative exons, and inclusion of these alternative exons during RNA splicing may generate C-terminally truncated short isoforms (splice variants) which lack RNA-binding motifs. However, expression of these short SON isoforms has not been confirmed in any types of cells and functions of the isoforms remain unexplored. Using 3’ rapid amplification of cDNA end (3’ RACE), we confirmed that short SON isoforms are indeed expressed in hematopoietic cells, and the included alternative exon provides the 3’ UTR and polyadenylation signal different from those of full-length SON transcript. To further examine SON isoform expression, we designed primers targeting specific alternative exons of SON and screened the level of full-length SON and the short isoforms. Our quantitative PCR data showed that lineage marker negative (Lin-) bone marrow cells highly express full-length SON, but not short isoforms, when compared to total bone marrow cells. Interestingly, we found that the levels of short SON isoforms are noticeably high in acute myeloid leukemia (AML) patient bone marrow cells, while full-length SON is downregulated when compared to normal bone marrow cells. These expression patterns were consistent with data analyses in a cancer microarray database (Oncomine). Furthermore, we found that short isoforms, but not full-length SON, were downregulated during PMA-induced differentiation of HL-60 and K562 cells. These results suggest that while full-length SON is the major form in normal hematopoietic stem cells/progenitors, the production of short SON isoforms through alternative exon inclusion is aberrantly activated in leukemic cells, likely due to a factor associated with impaired differentiation. To address whether the short SON isoforms affect the function of full-length SON in RNA splicing, we examined RNA splicing efficiency using a minigene containing SON-dependent exon-intron junction. As we expected, the short isoform alone, which lacks RNA-binding motifs, was not able to process minigene RNA splicing. However, to our surprise, co-expression of a short isoform together with full-length SON caused an increase in spliced RNA product from a minigene. These results suggest that short isoform expression potentiates the full-length SON function during exon recognition. Taken together, our results reveal that inclusion/skipping of the alternative exons within the primary SON transcript is abnormally regulated in myeloid leukemia, resulting in upregulation of short splice variants of SON. Furthermore, fine-tuning of RNA splicing efficiency by short SON isoforms implicates potential roles of these isoforms in RNA processing and global gene expression during hematopoiesis and leukemogenesis. Disclosures: No relevant conflicts of interest to declare.
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Rengel Jara, Eduardo Vicente, Jackson Wayne Babb, and Timothy Marshall Flohr. "Status and scope of project management in the hospitality industry." International Hospitality Review 33, no. 2 (December 2, 2019): 142–49. http://dx.doi.org/10.1108/ihr-09-2019-0016.
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Purpose Project management is an essential skill in the hospitality organization that is only becoming more important (Tereso et al., 2019). Bridging the gap between academia and industry is achievable by experiential learning or providing students with curriculum that gives them hands-on access to real-world industry research projects that attempt to solve real-world industry issues (Steed and Schwer, 2003). The purpose of this paper is to understand the scope of project management curriculum in universities’ hospitality programs, to understand the scope of project management skill requirements in hospitality firms and to narrow the disconnect between project management in academia and in hospitality firms. Design/methodology/approach The study used a mixed method approach. On the side of academia, a quantitative collection method was used to gage which universities offered a project management course, how many universities offer these courses and how many project management courses each university had. On the side of industry, a survey was administered to industry professionals in senior management positions. It was a quantitative survey designed to gage the importance of having project management as part of university curriculum. The aim was to show what was expected to be a disconnect between the two sides – academia and industry. A total of 57 responses were collected. Out of them 49 were usable. The Human Subjects consisted solely of two populations: individuals who worked in the hospitality industry. This accounted for 12 of the responses; individuals who worked in academia – more specifically in higher education at schools that offer Hospitality Management curriculum. This accounted for 37 of the responses. The subjects were identified and recruited through the professional networking site LinkedIn (for subjects that were industry professionals) and through both LinkedIn and American Hotel Lodging and Educational Institute databases for the subjects in academia. There were no direct potential benefits to the subject. The potential societal benefits of the study were the advancement of knowledge within the disciplines of both Hospitality Management and Project Management. The authors used the University of Memphis’ Qualtrics system and changed settings to anonymize responses so IP addresses would not be collected. The Qualtrics’ default is to collect IP addresses and GPS coordinates of those who responded. By setting the survey to anonymized responses the investigators were not able to collect this identifiable information. This information was included in the confidentiality, methods/procedures and in any other necessary sections/documents noting that the investigators would set Qualtrics to anonymize responses. Findings H1 was supported. The findings showed that most colleges and universities did not require project management classes for degree completion. Preliminary research showed that of 68 of the top hospitality programs in the world that were researched, only 7.5 percent required taking project management centric courses in order to graduate (College Choice, 2019; The Best Schools, 2019; Top Universities, 2018). In total, 43.2 percent of respondents answered “yes” when asked if their school offers courses in project management based on this definition of project management: “A project is temporary in that it has a defined beginning and end in time, and therefore the defined scope and resources. And a project is unique in that it is not a routine operation, but a specific set of operations designed to accomplish a singular goal. A project team often includes people who do not usually work together – sometimes from different organizations and across multiple geographies. Project management, then, is the application of knowledge, skills, tools, and techniques to project activities to meet the project requirement” (Project Management Institute) (See Table A1). Of 43.2 percent that answered yes, 64.3 percent said that the courses were required for graduation (See Table AII). Meaning, only 27.8 percent of schools surveyed offered and required completing project management courses for graduation. It should be noted that this number may be lower as bias may have played a factor. It is evident that hospitality programs understand the importance of project management because 85.7 percent of the colleges and universities surveyed are teaching project management concepts in courses that are not project management centric, like Meeting and Event Planning (See Table AIII). H2 was supported. Only 9.1 percent of respondents believed that project management skills are not at all important to line level employees. Most, 54.6 percent, believed that project management skills are important to some extent for line level employees. In total, 9.1 percent believed that project management skills are not at all important for supervisory level employees; 27.3 percent believed they are needed to some extent and 36.4 percent believed they are needed to a moderate extent. As for management level employees, it was found that 63.6 percent believed project management skills were needed to a great extent. For director level employees, 63.6 percent believed project management skills are necessary. Finally, 72.7 percent of respondents believed project management skills are necessary for both VP level employees and executive leadership (See Table AIV). It should be noted that one person did not believe themselves qualified to answer questions regarding project management within their organization. More than half of respondents said that project management skills are used to a great extent within their organization. H3 was not supported. Both hospitality schools and hospitality companies agreed that project management skills have some level of importance in academia and in industry – most believed the skills were very important at both junctions (See Tables AV and AVI). However, in the preliminary research the authors found that 55 percent of the top 111 hospitality companies had project management positions, meaning that there was a potential need for project management courses in colleges and universities (Ranker, 2019). As stated earlier, only 7.5 percent of the top 68 colleges and universities required project management courses to be completed upon graduation. So, the discrepancy lies within the vastly different percentages between project management positions within companies and project management courses within schools. Research limitations/implications The data provided strong evidence that supported the idea that project management is not required in hospitality programs upon completion. This opens new avenues to research the reasons behind schools not offering project management courses or making it a requirement for degree completion. On the other hand, project management skills are considered to be needed by hospitality managers. This provides valuable information for future studies that look to close the gap between academia and industry. The results indicated that project management is important for hospitality companies and schools, but the lack of project management education in colleges and universities is evident. The results of this study provided good news to students that aim to work in hospitality companies, since they can improve their project management skills and encourage their programs to stay updated with the industry needs so that they can succeed in their professional lives. Though this was an exploratory study of the project management discipline within the hospitality industry – with a limited sample size – the data clearly justified that there is room for additional data collection and research in this area of study. Practical implications The results show that there is a disconnect between project management curriculum in schools and project management skill demand in the hospitality industry. The research should encourage schools to invest appropriate resources into required project management curriculum. The hospitality industry is vast in the types of businesses that fall under it. Project management is one skill set that can be useful across most of the different businesses in the hospitality industry. From a practical standpoint, providing students with a solid background in the project management discipline provides them an advantage in the highly competitive hospitality industry. It accomplishes this by providing the students with in-demand knowledge and competencies that are both universally accepted and highly regarded by hospitality management companies as a skill set that is widely used in the industry. Social implications There were limitations to this study. Some pieces may be improved in future research. The Qualtrics survey could have been reduced in number and order of questions for a better interaction and results. The use of the Qualtrics database might be helpful to reach a bigger population. Potential steps could be taken to reduce bias that may play a factor in the responses. For example, some respondents may have claimed that their schools offer project management curriculum when in fact they do not, or they do not know to what extent. Originality/value Project management is an essential skill in the hospitality organization that is only becoming more important (Tereso et al., 2019). Bridging the gap between academia and industry is achievable through experiential learning or providing students with curriculum that gives them hands-on access to real-world industry research projects that attempt to solve real-world industry issues (Steed and Schwer, 2003). Most graduate level curriculum at universities was found to hone skills like written and oral communications, problem solving and decision making, organization, time management and cost control (Steed and Schwer, 2003). It has been suggested that universities add project management curriculum and experiential learning to their programs for a more streamlined transition from academia to industry (Steed and Schwer, 2003). Existing research on this subject is a bit dated, so the objectives were: to understand the scope of project management curriculum in universities’ hospitality programs; to understand the scope of project management skill requirements in hospitality firms; to narrow the disconnect between project management in academia and in hospitality firms.
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Rejeb, Abderahman, Karim Rejeb, and John G. Keogh. "A bibliometric analysis of humanitarian logistics." Acta Technica Jaurinensis, April 29, 2022. http://dx.doi.org/10.14513/actatechjaur.00647.
Full textAbstract:
Recent years have seen a surge in interest in humanitarian logistics (HL) research. This study conducted a bibliometric analysis of 894 HL-related studies. The publications were chosen using a combination of keywords from their titles, abstracts and author-supplied keywords from the leading database Scopus. The publications were classified according to their publication year, country of origin, type of publication, most relevant journals, and most influential authors. The review’s findings indicate that over a four-decade period, HL research progressed through three distinct stages. In terms of national contribution, the United States of America leads with the most studies published on HL. Additionally, the HL literature is advanced primarily through academic journal articles. The Journal of Humanitarian Logistics and Supply Chain Management is the leading journal in the field, with 148 articles published. The study makes a significant contribution by providing relevant analysis that may inform and guide scholars and researchers as they explore the evolution of HL research and foster networking and collaboration opportunities across multiple institutions.
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JAFARI, Alireza, Seyedeh Belin TAVAKOLY SANY, and Nooshin PEYMAN. "The Status of Health Literacy in Students Aged 6 to 18 Old Years: A Systematic Review Study." Iranian Journal of Public Health, March 1, 2021. http://dx.doi.org/10.18502/ijph.v50i3.5584.
Full textAbstract:
Background: Adolescents and children are a core target population for health literacy (HL) studies and practice. There is limited knowledge regarding the HL skills and abilities that help young people and children in making health decisions. This study aimed to evaluate the status of HL in ongoing school students.
Methods: Literature searching was performed using nine databases (Web of Science, PubMed, Scopus, Google Scholar, Iranmedex, Magiran, Scientific Information Database) without restriction in time until January 2019, and database searches were supplemented with reference hand searches and gray literature. Cross-sectional and experimental studies with focuses on validated measures of HL in ongoing students were included.
Results: This systematic review of identified 17 studies and 199714 samples specifically studied on ongoing school students aged 6-18 years. Students and their mothers have a moderate level of HL in four dimensions of menstrual health, physical activity, breast self-test, and iron deficiency anemia, and most of them have a high level of HL only in terms of nutrition. The relationship of HL with health outcomes, health promotion behaviors, self-efficacy, self-mutilating behaviors, and self-care abilities was statistically significant. HL status is related to parents’ education level, socio-economic determinants (culture, family income, and environmental contextual factors), age groups, and media/digital communication channels.
Conclusion: This review identified seven main determinates that significantly affect HL status in the target group. This systematic review shows most of the ongoing school students had an inadequate level of HL skills. HL strategies have a potential impact on improving students’ health behaviors and life quality.
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CHAROGHCHIAN KHORASANI, Elham, Seyedeh Belin TAVAKOLY SANY, Arezoo OROOJI, Gordon FERNS, and Nooshin PEYMAN. "Health Literacy in Iranian Women: A Systematic Review and Meta-Analysis." Iranian Journal of Public Health, June 15, 2020. http://dx.doi.org/10.18502/ijph.v49i5.3203.
Full textAbstract:
Background: Inadequate health literacy (HL) is associated with poorer health outcomes and worse health care. Up to one-half of Iranian women have difficulty in interpreting medical information, and national HL assessment has been limited in Iran. We have undertaken a systematic review of the literature and used a metaanalysis to examine the situation of HL status in Iranian women, and determine the relationship between HL and self-efficacy, and self-care behaviors. Methods: Six databases (PubMed, Web of Science, Scopus, Google Scholar, Scientific Information Database) and other non-indexed citations were searched using a variety of keywords regarding HL and Iranian women. The bias risk was decreased by the involvement of two independent reviewers assessing study quality and eligibility of included articles. Results: The average HL scores were in the range of marginal or limited (63.08; 95% CI, 59.83–66.32) in the Iranian women. The HL score was significantly higher among pregnant women (67.55; 95% CI, 32.54– 82.57) and was lower in women with chronic disease (57.79; CI, 48.34-67.24). There was a significant association between HL and self-efficacy and self-care behaviors. Conclusion: The average level of HL in the period of the review was marginal among Iranian women. The relationship of HL with self-efficacy and self-care behaviors was statistically significant but moderate.
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Fan, Zhao-ya, Yuan Yang, and Fan Zhang. "Association between health literacy and mortality: a systematic review and meta-analysis." Archives of Public Health 79, no. 1 (July 1, 2021). http://dx.doi.org/10.1186/s13690-021-00648-7.
Full textAbstract:
Abstract Background To identify the relationship between health literacy (HL) and mortality based on a systematic review and meta-analysis. Methods Literature published from database inception until July 2020 was searched using the PubMed and Web of Science databases, using relevant keywords and clear inclusion and exclusion criteria. The search was limited to English language articles. Two reviewers independently selected studies and extracted data. Pooled correlation coefficients and their 95% confidence intervals (CI) between HL and mortality were estimated using Stata 15.0 software. Potential sources of heterogeneity were explored using subgroup analysis, sensitivity analysis, and meta-regression. Quality of the original studies that were included in the meta-analysis was evaluated using the Newcastle–Ottawa Scale. A funnel plot and Egger’s test were used to determine whether significant publication bias was present. Results Overall, 19 articles were included, reporting on a total of 41,149 subjects. Eleven were prospective cohort studies, and all articles were considered “good” quality. The most used screening instruments were the short Test of Functional Health Literacy (S-TOFHLA) in Adults and the Brief Health Literacy Screen (BHLS). Among 39,423 subjects (two articles did not report the number of patients with low HL), approximately 9202 (23%) had inadequate or marginal HL. The correlation coefficient between HL and mortality was 1.25 (95%CI = 0.25–0.44). Conclusion Lower HL was associated with an increased risk of death. This finding should be considered carefully and confirmed by further research.
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Alexiades Armenakas, Anthony, and Oliver K. Baker. "Implementation and analysis of quantum computing application to Higgs boson reconstruction at the large Hadron Collider." Scientific Reports 11, no. 1 (November 24, 2021). http://dx.doi.org/10.1038/s41598-021-01552-4.
Full textAbstract:
AbstractWith the advent of the High-Luminosity Large Hadron Collider (HL-LHC) era, high energy physics (HEP) event selection will require new approaches to rapidly and accurately analyze vast databases. The current study addresses the enormity of HEP databases in an unprecedented manner—a quantum search using Grover’s Algorithm (GA) on an unsorted database, ATLAS Open Data, from the ATLAS detector. A novel method to identify rare events at 13 TeV in CERN’s LHC using quantum computing (QC) is presented. As indicated by the Higgs boson decay channel $$H\rightarrow ZZ^*\rightarrow 4l$$ H → Z Z ∗ → 4 l , the detection of four leptons in one event may be used to reconstruct the Higgs boson and, more importantly, evince Higgs boson decay to some new phenomena, such as $$H\rightarrow ZZ_d \rightarrow 4l$$ H → Z Z d → 4 l . Searching the dataset for collisions resulting in detection of four leptons using a Jupyter Notebook, a classical simulation of GA, and several quantum computers with multiple qubits, the current application was found to make the proper selection in the unsorted dataset. Quantum search efficacy was analyzed for the incoming HL-LHC by implementing the QC method on multiple classical simulators and IBM’s quantum computers with the IBM Qiskit Open Source Software. The current QC application provides a novel, high-efficiency alternative to classical database searches, demonstrating its potential utility as a rapid and increasingly accurate search method in HEP.
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"Performance enhancement of cloud datacenters through replicated database server." Journal of Information Technology Research 15, no. 1 (January 2022): 0. http://dx.doi.org/10.4018/jitr.299948.
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Cloud computing has risen as a new computing paradigm providing computing, resources for networking and storage as a service across the network. Data replication is a phenomenon which brings the available and reliable data (e.g., maybe the databases) nearer to the consumers (e.g., cloud applications) to overcome the bottleneck and is becoming a suitable solution. In this paper, we study the performance characteristics of a replicated database in cloud computing data centres which improves QoS by reducing communication delays. We formulate a theoretical queueing model of the replicated system by considering the arrival process as Poisson distribution for both types of client request, such as read and write applications. We solve the proposed model with the help of the recursive method, and the relevant performance matrices are derived. The evaluated results from both the mathematical model and extensive simulations help to study the unveil performance and guide the cloud providers for modelling future data replication solutions.
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Salisbury, Lutishoor, Jozef Laincz, and Jeremy J. Smith. "Science and Technology Undergraduate Students' Use of the Internet, Cell Phones and Social Networking Sites to Access Library Information." Issues in Science and Technology Librarianship, no. 69 (May 1, 2012). http://dx.doi.org/10.29173/istl1549.
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Many academic libraries and publishers have developed mobile-optimized versions of their web sites and catalogs. Almost all database vendors and major journal publishers have provided a way to connect to their resources via the Internet and the mobile web. In light of this pervasive use of the Internet, mobile devices and social networking, this study examines the habits of 290 science and technology students (with majors in biology (51%), chemical engineering (15%), biological engineering (9%), kinesiology (5%), and animal science (4%)), to identify whether they use this technology for library-related activities. The primary objective of this study was to identify whether the students use the Internet, their cell phones, and/or social networking sites to access scholarly information available through the library. Specifically, we were interested in finding out: (1) how often students use the Internet and for what purposes; (2) what devices they use to access library information remotely; (3) for what purposes student use their cell-phones and whether they use them to access library resources, including our social networking sites; and (4) which social networking sites students use and for what purposes. Even though there are widespread uses of the Internet, cell phones, and social networking, this study found that the majority of the students surveyed do not readily identify them as a means to access library-provided databases, the library catalog or to retrieve full-text journal articles on demand or on the go. [ABSTRACT FROM AUTHOR]
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Manji, Sofiya, Charlene Garner, Delores Steinlicht, Sarah Edwards, and Sheila McDonald. "Do callers of young children with fever follow the self-care recommendations given by a nursing triage line?" International Journal of Population Data Science 3, no. 4 (September 5, 2018). http://dx.doi.org/10.23889/ijpds.v3i4.876.
Full textAbstract:
IntroductionThe management of fever can be a stressful situation for caregivers of young children. Accessing emergency departments and urgent care centres (ED/UCCs) due to concerns about fever and the potential consequences of child fever is common, despite fever rarely being considered a medical emergency.
Objectives and ApproachDetermine the non-compliance rate with public health advice for self-care at home for young children (3-35 months) with a fever. Non-compliance was defined based on the presence of a record of healthcare use within 72 hours following a call to a nurse telephone triage line, Health Link (HL), and receiving a self-care recommendation. Callers between October 2015-March 2016 were identified and linked with four databases: registry files, National Ambulatory Care Reporting System; Inpatient-Discharge Abstract Database and Physician Claims (N = 879). Overall non-compliance rate and descriptive analysis by child age, caregiver age, geography, and call time were completed.
ResultsThe overall non-compliance rate with HL advice was 35.6%. Among callers, 17.5% visited an ED/UCC, 1.1% had an inpatient hospital admission, and 21.3% visited a physician’s office. Among the patients that utilized health care services after the HL call, 13.6% only visited ED/UCC, 18% only visited a physician’s office, and 4% utilized more than one type of health care service. Callers in rural and rural remote areas had lower odds of visiting a physician’s office compared to the urban areas (p-value <0.01). No significant differences were found by child age, caregiver age or time of call.
Conclusion/ImplicationsFindings of this study suggest that approximately one-third of callers are not following the telephone triage advice, potentially leading to unnecessary increased burden on the healthcare system. Further study is warranted to examine reasons for non-compliance. Strategies to increase compliance in caregivers should be explored.