Journal articles: 'HKD'

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Remschmidt, Helmut. "Global consensus on ADHD/HKD." European Child & Adolescent Psychiatry 14, no. 3 (June 2005): 127–37. http://dx.doi.org/10.1007/s00787-005-0439-x.

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del Carmen Ponce-Rodríguez, Ma, Francisco Oscar Carrete-Carreón, Gerardo Alonso Núñez-Fernández, José de Jesús Muñoz-Ramos, and María-Elena Pérez-López. "Keyline in Bean Crop (Phaseolus vulgaris L.) for Soil and Water Conservation." Sustainability 13, no. 17 (September 6, 2021): 9982. http://dx.doi.org/10.3390/su13179982.

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Soil erosion is a common problem worldwide, and in Durango, Mexico, it occurs in 77.4% of territory. Faced with this problem, the hydrological keyline design (HKD) is an alternative that helps to retain soil, increase infiltration, and keep the water uniformly in the land in order to recover its fertility. The objective of this research was to evaluate the effect of HKD on moisture and soil conservation in a rainfed agricultural plot during the spring–summer 2018 cycle with a bean crop (Phaseolus vulgaris L.) in the state of Durango, Mexico. Two treatments were established: control and HKD. The variables to measure the effect of the treatments were: soil water content, water erosion, bean yield, and yield components. The results indicated differences (p < 0.05) between treatments for the moisture and erosion variables; the HKD retained more water than the control by five percent, while sediment transport was lower in the HKD. No differences (p > 0.05) were found regarding bean yield and yield components. However, the yield was 126% higher than regional average in terms of rainfed bean production. Therefore, the implementation of the HKD had a positive impact by retaining soil and moisture.

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Hebrang Grgić, Ivana. "Znanstvene i stručne publikacije Hrvatskoga knjižničarskog društva." Vjesnik bibliotekara Hrvatske 61, no. 2 (March 18, 2019): 29–46. http://dx.doi.org/10.30754/vbh.61.2.676.

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Cilj. Cilj je rada opisati ulogu nakladničke djelatnosti Hrvatskoga knjižničarskog društva (HKD) te istražiti navike i interese čitatelja publikacija koje objavljuje HKD. Pristup/metodologija/dizajn. Na temelju dostupne literature i ranijih istraživanja prikazuje se nakladnička djelatnost HKD-a. Metodom analize sadržaja mrežnih stranica i uvidom u publikacije prikupljeni su podaci o znanstvenom, odnosno stručnom karakteru publikacija. Metodom online upitnika ispitani su čitatelji publikacija HKD-a o svojim čitateljskim navikama i interesima. Anketa je distribuirana članovima i nečlanovima HKD-a koji su zaposleni u raznim vrstama hrvatskih knjižnica. Rezultati. Prvi dio istraživanja pokazao je da je udio znanstvenih i stručnih publikacija, odnosno članaka podjednak, ali se posljednjih nekoliko godina zamjećuje tendencija porasta broja znanstvenih publikacija, odnosno članaka. Anketno istraživanje pokazalo je da je interes za publikacije HKD-a velik – ispitanici redovito čitaju i u svakodnevnom radu koriste sve publikacije HKD-a, mnogi su ispitanici i autori priloga ili su zainteresirani to postati. Vjesnik bibliotekara Hrvatske (VBH) povremeno ili redovito čita više od 97 % ispitanika, a HKD Novosti više od 93 % ispitanika. Knjige u izdanju HKD-a u svakodnevnom radu i cjeloživotnom obrazovanju koristi 91 % ispitanika. Nakladnička djelatnost HKD-a jedna je od temeljnih djelatnosti Društva i od velikoga je značaja za razvoj knjižničarske struke, ali i znanstvene grane knjižničarstvo unutar polja informacijskih i komunikacijskih znanosti. Originalnost/vrijednost. Analizom je dokazano da HKD sve češće objavljuje znanstvene publikacije, pa se stoga može smatrati i znanstvenom, a ne samo stručnom, udrugom. Nakladnička djelatnost HKD-a ima dugu tradiciju, ali se s vremenom susreće s problemima pri produkciji publikacija. Rezultati istraživanja mogu pomoći u rješavanju opisanih problema i planiranju nakladničke djelatnosti.

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Hassan, Sarmina, Irma M. Sainz, Mohammad M. Khan, Harlan N. Bradford, Irma Isordia-Salas, Sakeen W. Kashem, R. Balfour Sartor, and Robert W. Colman. "Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo." American Journal of Physiology-Heart and Circulatory Physiology 292, no. 6 (June 2007): H2959—H2965. http://dx.doi.org/10.1152/ajpheart.00730.2006.

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High-molecular-weight kininogen (HK) and its domain 3 (D3) exhibit anticoagulant properties and inhibit platelet activation at low thrombin concentration in vitro. We hypothesized that the rapid occlusive thrombosis in HK-deficient (HKd) rats following endothelial injury of the aorta results from enhanced platelet aggregation by thrombin. The effects of D3 (G235-M357) or D3-derived peptides on thrombosis in vivo were tested. D3 and its exon 7C terminal peptide (E7CP, K270-Q292), expressed as glutathione S-transferase (GST) fusion proteins (GST-D3, GST-E7CP), or GST alone, as well as cleaved HK (HKa) or synthetic peptide E7CP, were infused intravenously 10 min before endothelial injury. Blood flow was reduced down to 10% of baseline flow within 28 ± 5.2 min by a platelet-fibrin thrombus in GST-treated HKd rats compared with >240 min in GST-treated normal HK rats (wild type). GST-D3, GST-E7CP, HKa, or E7CP infusion prolonged the flow time to 233, >240, 223, and >240 min, respectively, in HKd rats. When GST-E7CP was infused 10 min after the injury, blood flow was maintained for >240 min. Thrombin-antithrombin concentrations were elevated by injury in HKd rats receiving GST from 35 to 55 μg/l and decreased with GST-E7CP, HKa, or E7CP reconstitution to 40, 15, and 9 μg/l, respectively. We conclude that HKd rats are prothrombotic and that HKa, kininogen D3, and its fragment E7CP modulate arterial thrombosis after endothelial injury.

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Kim, Hye-Rim, Hyun-Seok Jin, and Yong-Bin Eom. "A Genome-Wide Association Study for Hypertensive Kidney Disease in Korean Men." Genes 12, no. 5 (May 17, 2021): 751. http://dx.doi.org/10.3390/genes12050751.

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Hypertension is one of the major risk factors for chronic kidney disease (CKD), and the coexistence of hypertension and CKD increases morbidity and mortality. Although many genetic factors have been identified separately for hypertension and kidney disease, studies specifically focused on hypertensive kidney disease (HKD) have been rare. Therefore, this study aimed to identify loci or genes associated with HKD. A genome-wide association study (GWAS) was conducted using two Korean cohorts, the Health Examinee (HEXA) and Korean Association REsource (KARE). Consequently, 19 single nucleotide polymorphisms (SNPs) were found to be significantly associated with HKD in the discovery and replication phases (p < 5 × 10−8, p < 0.05, respectively). We further analyzed HKD-related traits such as the estimated glomerular filtration rate (eGFR), creatinine, blood urea nitrogen (BUN), systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the 14q21.2 locus, which showed a strong linkage disequilibrium (LD). Expression quantitative trait loci (eQTL) analysis was also performed to determine whether HKD-related SNPs affect gene expression changes in glomerular and arterial tissues. The results suggested that the FANCM gene may affect the development of HKD through an integrated analysis of eQTL and GWAS and was the most significantly associated candidate gene. Taken together, this study indicated that the FANCM gene is involved in the pathogenesis of HKD. Additionally, our results will be useful in prioritizing other genes for further experiments.

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ZHENG, Victor, and Roger LUK. "From Locodollar to Asianyuan: Hong Kong Dollar at a Crossroads." East Asian Policy 04, no. 02 (April 2012): 94–102. http://dx.doi.org/10.1142/s1793930512000190.

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After re-pegging the Renminbi (RMB) from the US Dollar (USD) to a currency basket, the Hong Kong Dollar (HKD) is caught between the diverging Chinese and US economies. Disparity between the RMB and USD exchange rates and the HKD, and the disharmony of Chinese and US monetary policies towards Hong Kong have become increasingly acute. Hong Kong is at a crossroads. Should the HKD migrate from the dollar-zone to the renminbi-zone and realign with the national currency, and how? This paper analyses the mismatch and tries to answer the question.

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7

Kądziela-Olech, Halina. "After-effects of hyperkinetic disorder (HKD) in prospective longitudinal (12 years) study." Postępy Psychiatrii i Neurologii 26, no. 2 (2017): 57–62. http://dx.doi.org/10.5114/ppn.2017.69373.

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Sapir, Shimon. "Multiple Factors Are Involved in the Dysarthria Associated With Parkinson's Disease: A Review With Implications for Clinical Practice and Research." Journal of Speech, Language, and Hearing Research 57, no. 4 (August 2014): 1330–43. http://dx.doi.org/10.1044/2014_jslhr-s-13-0039.

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Purpose Motor speech abnormalities are highly common and debilitating in individuals with idiopathic Parkinson's disease (IPD). These abnormalities, collectively termed hypokinetic dysarthria (HKD), have been traditionally attributed to hypokinesia and bradykinesia secondary to muscle rigidity and dopamine deficits. However, the role of rigidity and dopamine in the development of HKD is far from clear. The purpose of the present study was to offer an alternative view of the factors underlying HKD. Method The authors conducted an extensive, but not exhaustive, review of the literature to examine the evidence for the traditional view versus the alternative view. Results The review suggests that HKD is a highly complex and variable phenomenon including multiple factors, such as scaling and maintaining movement amplitude and effort; preplanning and initiation of movements; internal cueing; sensory and temporal processing; automaticity; emotive vocalization; and attention to action (vocal vigilance). Although not part of the dysarthria, nonmotor factors, such as depression, aging, and cognitive-linguistic abnormalities, are likely to contribute to the overall speech symptomatology associated with IPD. Conclusion These findings have important implications for clinical practice and research.

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Nosadini, R., A. Avogaro, R. Trevisan, E. Duner, C. Marescotti, E. Iori, C. Cobelli, and G. Toffolo. "Acetoacetate and 3-hydroxybutyrate kinetics in obese and insulin-dependent diabetic humans." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 248, no. 5 (May 1, 1985): R611—R620. http://dx.doi.org/10.1152/ajpregu.1985.248.5.r611.

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[3-14C]acetoacetate (AcAc) and beta-[3-14C]hydroxybutyrate (beta-OHB) administration, measurements of labeled AcAc and beta-OHB in blood, and kinetic modeling have been used to investigate ketone body (KB) metabolism in five normal, five obese, and eight insulin-withdrawn diabetic subjects. Diabetic subjects were divided in mildly ketotic (MKD) and highly ketotic (HKD) patients according to beta-OHB blood level. A four-compartmental model successfully described the tracer kinetic data in obese and normal subjects, whereas in diabetic patients a five-compartmental model was necessary. Obese subjects showed a significantly lower (P less than 0.05) KB de novo synthesis (R30 = 159 +/- 54 (SD) mumol X min-1 X m-2) in comparison with normal subjects (282 +/- 93), but the clearance rates of AcAc (PCR1) and beta-OHB (PCR2) were similar in the two groups. R30 was 596 +/- 534 in MKD and 1,278 +/- 445 (P less than 0.01) in HKD. PCR1 was not significantly different both in MKD and HKD in comparison with normal subjects. In contrast PCR2 was markedly reduced in HKD (0 +/- 0 ml X min-1 X m-2) in comparison with MKD (1,031 +/- 615) and normal subjects (782 +/- 278). The percentage distribution of KB among various tissues inside the organism of diabetic subjects is abnormal. Both AcAc and beta-OHB recycling and mean residence time are not normal in HKD. A significant correlation was found between C-peptide and KB production in diabetes. These results suggest that a selective defect of beta-OHB peripheral utilization is important in determining and maintaining severe diabetic ketoacidosis.

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YEE, HONG BEN, and NIKOLAI DOKUCHAEV. "CONSTRUCTION OF MODELS FOR BOUNDED PRICE PROCESSES: THE CASE OF THE HKD EXCHANGE RATE." Annals of Financial Economics 10, no. 02 (December 2015): 1550011. http://dx.doi.org/10.1142/s2010495215500116.

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This paper discusses construction of evolution models for financial time series evolving within a given interval. We calibrated a model for the case of the USD/HKD exchange rate after the separation of strong and weak side convertibility undertakings, in which the rate is confined to a specified corridor. This process represents an interesting example of a tradable bounded process. A one-dimensional (1D) model was able to replicate the bounded distribution of the process, but a two-dimensional (2D) model better captured dynamics as measured by the volatility without losing features of the 1D model. We briefly consider the ergodic properties of these models.

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XU, GUANGLI, SHIYU SONG, and YONGJIN WANG. "THE VALUATION OF OPTIONS ON FOREIGN EXCHANGE RATE IN A TARGET ZONE." International Journal of Theoretical and Applied Finance 19, no. 03 (April 21, 2016): 1650020. http://dx.doi.org/10.1142/s0219024916500205.

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This paper derives a simple model to analyze foreign exchange rate behavior under a target zone regime. From the real market data of exchange rate of US Dollar (USD) to Hong Kong Dollar (HKD) (USD/HKD), somewhat surprisingly, we find that some of the observations fall outside the stated range. Consequently, a so-called skew CIR model for this exchange rate which has a probability of exceeding the stated boundary is developed. A spectral expansion approach is used to analyze the model. The valuation of the barrier and the one-touch options for the derivative written on the exchange rate is studied in the end.

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Heubeck, Bernd G., Thomas A. Otte, and Gerhard W. Lauth. "Consumer evaluation and satisfaction with individual versus group parent training for children with hyperkinetic disorder (HKD)." British Journal of Clinical Psychology 55, no. 3 (December 12, 2015): 305–19. http://dx.doi.org/10.1111/bjc.12101.

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Alexander, Clint AD, Calvin N. Peters, David R. Marmorek, and Paul Higgins. "A decision analysis of flow management experiments for Columbia River mountain whitefish (Prosopium williamsoni) management." Canadian Journal of Fisheries and Aquatic Sciences 63, no. 5 (May 1, 2006): 1142–56. http://dx.doi.org/10.1139/f06-032.

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High spawning flows from Hugh Keenleyside Dam (HKD) on the Columbia River results in dewatering of eggs in mountain whitefish (Prosopium williamsoni) populations, but the ultimate effect on adult abundance depends on the shape of the egg-to-adult recruitment curve. Our decision analysis assessed the benefits of alternative flow experiments while accounting for uncertainties in this relationship and in flows in the Columbia and Kootenay rivers. The value of experimenting depended on the true recruitment relationship, how we quantified experimental benefits, and experimental design. With current uncertainty, the optimal HKD spawning flow (out of 11 alternative flows) was 1699.2 m3·s1. Spawning flows below 1699.2 m3·s1 did not improve egg survival because lower flows rendered high-quality spawning habitat unavailable and increased scour mortality. Two experimental designs, both with higher precision monitoring, had a high probability of detecting the true recruitment curve at reasonable cost. Information from these experiments suggested an optimal spawning flow of 1699.2 m3·s1 if adult abundance were sensitive to egg mortality or 1982.4 m3·s1 if the population were insensitive.

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YEE, HONG BEN. "ON THE IMPACT OF THE BOUNDARY ON DYNAMICS: ANTI-PERSISTENCE IN THE CASE OF THE HKD EXCHANGE RATE CORRIDOR." Annals of Financial Economics 10, no. 01 (June 2015): 1550006. http://dx.doi.org/10.1142/s2010495215500062.

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This paper studies the features of the USD/HKD exchange rate process by assessing the conformity of its dynamics to that of a random walk. This is not a trivial task since we consider the period within which the rate is confined to a specified corridor. This is achieved via analysis of its fractal dimension by means of the Hurst exponent as estimated using the rescaled range method. The conformity can be quantified by the difference between the estimated Hurst exponent and the random walk Hurst exponent of ½. At least two distinct Hurst exponents are identified, one corresponding to a random walk while the other, to an anti-persistent process. Partitioning the rate in state space associates the anti-persistence with proximity to the lower boundary of the corridor so the rate can be modeled using a random walk when sufficiently distant from the boundary.

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Li, Li, Xuemei He, Jian Sun, Changbao Li, Dongning Ling, Jinfeng Sheng, Xiangrong You, et al. "Cloning, Characterization, and Functional Expression of Phospholipase Dα cDNA from Banana (Musa acuminate L.)." Journal of Food Quality 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/2510949.

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Phospholipase D (PLD) plays a key role in adaptive responses of postharvest fruits. A cDNA clone of banana (Musa acuminate L.) PLDα (MaPLDα) was obtained by RT-PCR in this study. The MaPLDα gene contains a complete open reading frame (ORF) encoding a 92-kDa protein composed of 832 amino acid residues and possesses a characteristic C2 domain and two catalytic H×K×××D (abbr. HKD) motifs. The two HKD motifs are separated by 341 amino acid residues in the primary structure. Relatively higher PLD activity and expression of MaPLDα mRNA were detected in developing tissues compared to senescent or mature tissues in individual leaves, flower, stem, and fruit organs, respectively. The expression profile of PLDα mRNA in postharvest banana fruits at different temperatures was determined, and the MaPLDα mRNA reached the highest expression peak on day 5 at 25°C and on day 7 at 12°C. The results provide useful information for maintaining postharvest quality and extending the storage life of banana fruit.

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Devaraj, Santhana G. T., Warren Fiskus, Bhavin Shah, Sunil Sharma, Jun Qi, Baohua Sun, Saikat Saha, et al. "Mechanistic Role of HEXIM1 Induction in BRD4-Antagonist Mediated Growth Inhibition, Differentiation and in Vivo Lethal Activity Against Human AML Blast Progenitor Cells." Blood 124, no. 21 (December 6, 2014): 3534. http://dx.doi.org/10.1182/blood.v124.21.3534.3534.

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Abstract The BET (bromodomain and extra terminal) protein family, including BRD4 are chromatin reader proteins that bind to acetylated lysines on histone proteins and recruit transcriptional regulatory complexes to gene promoters, thereby coupling histone acetylation to RNA polymerase II (RNAP2)-mediated transcript elongation. Preferential binding of BRD4 to clustered enhancers or ‘super enhancers’ enables BRD4, through the mediator complex, to regulate the transcription of specific oncogenes, including c-MYC, BCL2 and CDK4/6 in AML blast progenitor cells (BPCs). Through its C-terminal domain (CTD), BRD4 recruits pTEFb (positive transcription elongation factor b), the heterodimer composed of cyclin T and CDK9, which phosphorylates the heptad repeats on the CTD of RNAP2 at serine 2. The kinase activity of CDK9 in pTEFb is also required for the phosphorylation of DSIF and NELF, which abrogates their inhibitory hold on the pause-release of RNAP2 and productive transcript elongation of specific oncogenes and their target genes. pTEFb exists in two forms, the catalytically active form, which is associated with BRD4 and RNAP2, and a catalytically inactive form associated with 7SK snRNP (small nuclear ribonucleoprotein) and the inhibitory protein HEXIM1 (hexamethylene bis-acetamide or HMBA-inducible protein 1). The transition of pTEFb between the inactive and active complex is dynamic and regulated by cell growth and stress signaling. HEXIM1 binds to and sequesters pTEFb, thereby inhibiting its kinase activity for RNAP II. We recently reported (Mol Cancer Ther, 2014) that the BRD4 antagonist JQ1 and I-BET151 alone, and synergistically with the pan-histone deacetylase inhibitor panobinostat, inhibits the growth and induces apoptosis in cultured (OCI-AML3 and MOLM13) and patient-derived primary AML (pAML) BPCs. JQ1 treatment also improved the survival of the immune-depleted mice engrafted with MOLM13 or pAML BPCs. Notably, the lethal activity of JQ1 was associated with marked induction of HEXIM1. Therefore, we hypothesized that HEXIM1 induction, by sequestering pTEFb and inhibiting RNAP2, contributes to the growth inhibitory and lethal effects of JQ1. We additionally hypothesized that co-treatment with those agents that further augment HEXIM1 induction would synergize with JQ1 against AML BPCs. To validate these hypotheses, we achieved a stable lentivirus mediated knockdown (KD) of the mRNA and protein expressions of HEXIM1 by approximately 90% in OCI-AML3 and MOLM13 cells, as well as transient KD in pAML BPCs. Compared to the parental control cells, OCI-AML3/HKD and MOLM13/HKD cells showing HEXIM1 knockdown (HKD) exhibited reduced binding of HEXIM1 with cyclin T (as revealed by cyclin T pull-down and immunofluorescence microscopy), but showed augmented suspension culture growth and increased protein levels (by Western blot) of cyclin T, pRNAP2 and cMYC levels. However, in contrast to the parental control cells, JQ1 (1000 nM) treatment-mediated HEXIM1 induction and binding to cyclin T was markedly inhibited in the HKD AML BPCs, which was associated with significant inhibition of JQ1-induced pRNAP2, as well as differentiation and apoptosis of HKD BPCs (p < 0.01). Notably, whereas treatment with JQ1 alone improved the median survival of NOD/SCID mice engrafted with MOLM13 BPCs, this survival improvement was significantly impaired in the mice engrafted with MOLM13/HKD AML BPCs (p < 0.02). This indicated that HEXIM1-induction mechanistically contributes to JQ1-induced growth inhibition, differentiation and apoptosis of AML BPCs. Further, the synergistic apoptosis observed in MOLM13, OCI-AML3 and primary AML cells induced by co-treatment with JQ1 (250 to 1000 nM) and PS (5 to 10 nM) or HMBA (1 to 2 mM) was also associated with greater induction of HEXIM1. However, this synergy was impaired in the cultured and pAML BPCs with HEXIM1 knockdown. These findings confirm that HEXIM1 induction is a biomarker and plays a mechanistic role in mediating growth inhibition, differentiation and apoptosis induced by BRD4 antagonist in human AML BPCs. These findings support, and we have embarked upon, studies involving future pre-clinical development of those agents that in combination significantly augment BRD4 antagonist-induced HEXIM1 in human AML BPCs. Disclosures No relevant conflicts of interest to declare.

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Kadziela-Olech, Halina, Piotr Cichocki, Justyna Chwiesko, Jerzy Konstantynowicz, and Jan Józef Braszko. "Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD." European Child & Adolescent Psychiatry 24, no. 1 (March 17, 2014): 55–63. http://dx.doi.org/10.1007/s00787-014-0533-z.

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Roper, Rachel L., and Bernard Moss. "Envelope Formation Is Blocked by Mutation of a Sequence Related to the HKD Phospholipid Metabolism Motif in the Vaccinia Virus F13L Protein." Journal of Virology 73, no. 2 (February 1, 1999): 1108–17. http://dx.doi.org/10.1128/jvi.73.2.1108-1117.1999.

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ABSTRACT The outer envelope of the extracellular form of vaccinia virus is derived from Golgi membranes that have been modified by the insertion of specific viral proteins, of which the major component is the 37-kDa, palmitylated, nonglycosylated product of the F13L gene. The F13L protein contains a variant of the HKD (His-Lys-Asp) motif, which is conserved in numerous enzymes of phospholipid metabolism. Vaccinia virus mutants with a conservative substitution of either the K (K314R) or the D (D319E) residue of the F13L protein formed only tiny plaques similar to those produced by an F13L deletion mutant, were unable to produce extracellular enveloped virions, and failed to mediate low-pH-induced fusion of infected cells. Membrane-wrapped forms of intracellular virus were rarely detected in electron microscopic images of cells infected with either of the mutants. Western blotting and pulse-chase experiments demonstrated that the D319E protein was less stable than either the K314R or wild-type F13L protein. Most striking, however, was the failure of either of the two mutated proteins to concentrate in the Golgi compartment. Palmitylation, oleation, and partitioning of the F13L protein in Triton X-114 detergent were unaffected by the K314R substitution. These results indicated that the F13L protein must retain the K314 and D319 for it to localize in the Golgi compartment and function in membrane envelopment of vaccinia virus.

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Li, Kun. "Weakness in HK Currency Board System and Trading Opportunities in Betting A De-Peg of the Hong Kong Dollar." International Finance and Banking 4, no. 1 (March 21, 2017): 95. http://dx.doi.org/10.5296/ifb.v4i1.10969.

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Hong Kong (HK) adopted the Linked Exchange Rate (LER) system in 1983, and it has been operating successfully for more than three decades. However, the maintenance costs for the LER system have grown exorbitantly and could outpace the costs of an exit, especially under the combined influence of a slow-down of the Chinese economy and a possible interest rate hike in the U.S. The HK government currently holds much more foreign reserves than it did preceding the 1997 Asian Financial Crisis. The HK government is also facing political unrest and growing anger of low income residents towards wealth inequality. This opposition could eventually force the HK government to abandon the Currency Board System. At present, the cost of exiting the LER system is small thanks to a strong HKD sustained by large capital inflows from mainland China. However, the time frame for such a low-cost exit is short.In our view, the HK government is likely to maintain the current system, even at high social and economic costs, in the expectation that changing external factors, such as the rebound of the Chinese economy, will relieve the de-pegging pressure. In this report, we explore several approaches to gauge the timing and risks of a de-pegging of the HKD and the collapse of the Chinese housing bubble. At the same time, we analyze the potential impact of a de-pegging on HK’s local companies and the most vulnerable parts of the system.

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Duda, David P., and Patrick Minnis. "Basic Diagnosis and Prediction of Persistent Contrail Occurrence Using High-Resolution Numerical Weather Analyses/Forecasts and Logistic Regression. Part I: Effects of Random Error." Journal of Applied Meteorology and Climatology 48, no. 9 (September 1, 2009): 1780–89. http://dx.doi.org/10.1175/2009jamc2056.1.

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Abstract Straightforward application of the Schmidt–Appleman contrail formation criteria to diagnose persistent contrail occurrence from numerical weather prediction data is hindered by significant bias errors in the upper-tropospheric humidity. Logistic models of contrail occurrence have been proposed to overcome this problem, but basic questions remain about how random measurement error may affect their accuracy. A set of 5000 synthetic contrail observations is created to study the effects of random error in these probabilistic models. The simulated observations are based on distributions of temperature, humidity, and vertical velocity derived from Advanced Regional Prediction System (ARPS) weather analyses. The logistic models created from the simulated observations were evaluated using two common statistical measures of model accuracy: the percent correct (PC) and the Hanssen–Kuipers discriminant (HKD). To convert the probabilistic results of the logistic models into a dichotomous yes/no choice suitable for the statistical measures, two critical probability thresholds are considered. The HKD scores are higher (i.e., the forecasts are more skillful) when the climatological frequency of contrail occurrence is used as the critical threshold, whereas the PC scores are higher (i.e., the forecasts are more accurate) when the critical probability threshold is 0.5. For both thresholds, typical random errors in temperature, relative humidity, and vertical velocity are found to be small enough to allow for accurate logistic models of contrail occurrence. The accuracy of the models developed from synthetic data is over 85% for the prediction of both contrail occurrence and nonoccurrence, although, in practice, larger errors would be anticipated.

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Baughman, Fred A. "Psychiatry’s “Chemical Imbalance” Fraud: Who Killed Rebecca Riley?" Ethical Human Psychology and Psychiatry 10, no. 2 (October 2008): 96–108. http://dx.doi.org/10.1891/1559-4343.10.2.96.

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All physicians attend medical school and learn of (a) all things physically normal; anatomy, physiology, and chemistry, (b) all things physically abnormal; pathology, disease, and (c) how to tell the difference. Diagnosis is the first obligation of every physician to every patient, and must precede treatment. Diagnosis first asks, “Is there a physical abnormality (physical abnormality = disorder = disease), yes or no?” Patients with no abnormality (no physical abnormality = no disorder = no disease = normal) are referred to as having “no evidence or disease” (NED) or “no organic disease” (NOD). Their problems may be psychological or psychiatric, but they are not medical or surgical. In patients found to have an abnormality, diagnosis now asks, “Which disease?” Psychiatrists are the only physicians who do not perform physical diagnosis. The absence of disease is determined for them by other physicians, usually referring physicians. In 1948 the previously conjoint specialty of neuropsychiatry was divided into neurology—responsible for the diagnosis and treatment or physical/organic disease of the nervous system—and psychiatry—responsible for the treatment of emotional and psychological problems, none of them due to organic diseases. Nor did psychiatry object to this scientific division of labor at the time. However, in the 1950s, with the advent of psychotropic drugs, psychiatry, increasingly in league with the pharmaceutical industry, began referring to psychological diagnoses as disorders/diseases/chemical imbalances of the brain, albeit with no proof or science. In a congressional hearing in 1970, psychiatrists and federal officials, including the Food and Drug Administration and the Department of Health, Education, and Welfare, represented hyperkinetic disorder (HKD) to be a disorder/disease of the brain leading to the appropriation of millions of dollars for research, diagnosis and treatment into the drug treatment of school children said to have the new disease HKD. HKD became ADD, then ADHD, a disorder/disease/chemical imbalance always in need of a “chemical balancer”—a pill. Without proof of an abnormality/disorder/disease, the ADHD epidemic grew from 150,000 in 1970 to 6 million to 7 million today, the most common childhood diagnosis in the United States, a multi-billion dollar industry, and a model for all 374 DSM–IV psychological/psychiatric diagnoses—none of them actual diseases. As such, psychiatry is not a legitimate branch of medicine deserving scientific-fiscal parity; rather, collectively, it is the greatest health care fraud in history. Every time a so-called chemical imbalance is diagnosed, a patient’s right to informed consent has been abrogated. Every time a medically normal person is treated with a psychotropic chemical balancer—a pill—their first and only abnormality is the iatrogenic intoxication: poisoning.

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Dukkon, Ágnes. "Klaus-Dieter Herbst, Biobibliographisches Handbuch der Kalendermacher, Jena, Verlag Historische Kalender Drucke, 2020 (Acta Calendariographica–Forschungsberichte, Bd. 9)." Magyar Könyvszemle 136, no. 4 (March 28, 2021): 374–77. http://dx.doi.org/10.17167/mksz.2020.4.374-377.

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Jelentős német kiadvánnyal gazdagodott a 2020-as évben a nemzetközi könyvtörténeti és művelődéstörténeti szakterület. Klaus-Dieter Herbst az Acta Calendariographica sorozat kilencedikkötetét – mely önmagában is négy részből áll – adta ki Jénában a HKD Verlag (Historische KalenderDrucke) gondozásában. Több mint két évtizedes kutatási munka és tanulmánykötetek, bibliográfiák,regiszterek, fakszimilék előzték meg a jelen kiadványt: nyolc kötet az ún. Forschungsberichtesorozatban, tíz pedig a párhuzamos Kalenderreihen sorozatban, amelyek negyedrét alakú ún.Schreibkalenderek fakszimile kiadásai. A közreadó és számos esetben a bevezető tanulmányok,jegyzetek, magyarázatok szerzője Klaus-Dieter Herbst asztronómiatörténész, az 1990-es évek másodikfelében kezdett foglalkozni kalendárium-kutatással, kezdetben elsősorban csillagászati éstudománytörténeti szempontokból.

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Gabriel, Dunja Marija, Sanja Bunić, and Amelia Kovačević. "Knjižnične usluge za osobe s teškoćama čitanja i disleksijom." Vjesnik bibliotekara Hrvatske 62, no. 1 (July 30, 2019): 167–87. http://dx.doi.org/10.30754/vbh.62.1.628.

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Cilj. Cilj ovog istraživanja bio je utvrditi vrstu i broj knjižničnih usluga, programa, opreme i građe za osobe s teškoćama čitanja i disleksijom u svim vrstama knjižnica u Hrvatskoj. Istraživanje je provedeno kao jedan od mogućih oblika vrednovanja Nacionalne kampanje za osobe s teškoćama čitanja i disleksijom „I ja želim čitati!“ Hrvatskog knjižničarskog društva (HKD-a) koja je pokrenuta u listopadu 2016. godine. Jedan od ključnih ciljeva Kampanje jest proširiti mrežu knjižnica koje provode programe za osobe s teškoćama čitanja i disleksijom. Metodologija. HKD-ova Komisija za knjižnične usluge za osobe s invaliditetom i osobe s posebnim potrebama provela je kao nositelj Kampanje anketno istraživanje u svim vrstama knjižnica u Hrvatskoj prije početka Kampanje. Istraživanje je provedeno od 8. kolovoza do 15. rujna 2016. godine, a na upitnik su odgovorile 572 knjižnice. Istraživanje je provedeno kao jedan od mogućih oblika vrednovanja Kampanje na način da će se nakon prve godine odvijanja Kampanje provesti još jedno takvo istraživanje i usporediti rezultati. Rezultati. U radu su predočeni rezultati istraživanja koji pokazuju informiranost, educiranost i senzibiliziranost knjižničarske zajednice za potrebe osoba s teškoćama čitanja i disleksijom, suradnju knjižnica i različitih institucija i udruga koje se bave osobama s teškoćama čitanja i disleksijom u pripremi aktivnosti za njihovo ravnopravno uključivanje u društvo, broj knjižničnih programa i usluga za osobe s teškoćama čitanja i disleksijom te broj knjižnica koje ih provode. Originalnost. Ovo je prvo cjelovito istraživanje o knjižničnim uslugama za osobe s teškoćama čitanja i disleksijom u svim vrstama knjižnica u Republici Hrvatskoj.

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Cavalcante, Isadora Pontes, Maria Claudia Nogueira Zerbini, Guilherme Asmar Alencar, Beatriz de Paula Mariani, Carlos Alberto Buchpiguel, Madson Queiroz Almeida, Berenice Bilharinho Mendonca, and Maria Candida Barisson Villares Fragoso. "High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3." Acta Radiologica 57, no. 3 (March 11, 2015): 370–77. http://dx.doi.org/10.1177/0284185115575195.

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Wang, Fanghua, Siyu Liu, Xuejing Mao, Ruiguo Cui, Bo Yang, and Yonghua Wang. "Crystal Structure of a Phospholipase D from the Plant-Associated Bacteria Serratia plymuthica Strain AS9 Reveals a Unique Arrangement of Catalytic Pocket." International Journal of Molecular Sciences 22, no. 6 (March 22, 2021): 3219. http://dx.doi.org/10.3390/ijms22063219.

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Phospholipases D (PLDs) play important roles in different organisms and in vitro phospholipid modifications, which attract strong interests for investigation. However, the lack of PLD structural information has seriously hampered both the understanding of their structure–function relationships and the structure-based bioengineering of this enzyme. Herein, we presented the crystal structure of a PLD from the plant-associated bacteria Serratia plymuthica strain AS9 (SpPLD) at a resolution of 1.79 Å. Two classical HxKxxxxD (HKD) motifs were found in SpPLD and have shown high structural consistence with several PLDs in the same family. While comparing the structure of SpPLD with the previous resolved PLDs from the same family, several unique conformations on the C-terminus of the HKD motif were demonstrated to participate in the arrangement of the catalytic pocket of SpPLD. In SpPLD, an extented loop conformation between β9 and α9 (aa228–246) was found. Moreover, electrostatic surface potential showed that this loop region in SpPLD was positively charged while the corresponding loops in the two Streptomyces originated PLDs (PDB ID: 1F0I, 2ZE4/2ZE9) were neutral. The shortened loop between α10 and α11 (aa272–275) made the SpPLD unable to form the gate-like structure which existed specically in the two Streptomyces originated PLDs (PDB ID: 1F0I, 2ZE4/2ZE9) and functioned to stabilize the substrates. In contrast, the shortened loop conformation at this corresponding segment was more alike to several nucleases (Nuc, Zuc, mZuc, NucT) within the same family. Moreover, the loop composition between β11 and β12 was also different from the two Streptomyces originated PLDs (PDB ID: 1F0I, 2ZE4/2ZE9), which formed the entrance of the catalytic pocket and were closely related to substrate recognition. So far, SpPLD was the only structurally characterized PLD enzyme from Serratia. The structural information derived here not only helps for the understanding of the biological function of this enzyme in plant protection, but also helps for the understanding of the rational design of the mutant, with potential application in phospholipid modification.

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Mulyadi, Mulyadi. "EFFECT OF EXCHANGE RATE AND GLOBAL INDEX IN FIVE COUNTRIES AGAINST CSPI." Journal of Accounting and Finance Management 1, no. 1 (June 24, 2020): 44–58. http://dx.doi.org/10.38035/jafm.v1i1.11.

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This study aimed to determine the correlation between Exchange Rate and Global Index on Composite Stock Price Index in Indonesia Stock Exchange in 2014-2019 partially and simultaneously. Exchange Rate and Global Index is proxied by five countries namely Hong Kong, Japan, USA, Singapore, and China. The data used is secondary data obtained through the Official Website of Bank Indonesia for variable Exchange Rate, Official Website Yahoo Finance and Official Website Investing.com for variable Global Index. The methods of data analysis used is multiple linear regression. The results showed that the HKD, JPY, USD, SGD, CNY, and STI partially insignificant on CSPI, as well as HSI and DJIA partially positive effect significant on CSPI, while N225 and SSEC partially negative effect significant on CSPI. Simultaneously, all the variables have a significant effect by influencing by 93.9% while the remaining 6.1% is explained by other variables not examined in this study.

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Kwong, Bruce Kam Kwan. "A Comparative Analysis of the Cash Handout Policy of Hong Kong and Macau." Journal of Current Chinese Affairs 42, no. 3 (September 2013): 87–100. http://dx.doi.org/10.1177/186810261304200305.

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In 2011, Hong Kong SAR government announced an unprecedented policy of cash handouts of 6,000 HKD to all permanent residents at the age of 18 or above as a means of defusing public discontent with economic policy and poor governance. Macau SAR has also been distributing similar cash handouts since 2008 to temper public dissatisfaction and widespread demonstrations. Initially, both SAR governments were very reluctant to initiate universal cash handouts. Unlike standard welfare programmes that are budgeted for annually, the cash payment scheme in Hong Kong SAR was a one-off handout. In Macau SAR, however, the payment scheme went from being a short-term policy to a long-term policy, while other welfare programmes were also allocated more public money. This paper argues that although such cash handout policies are avoidable, they are still being adopted by politicians who place self-interest above the public interest.

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Slagter, Margrita H., Andreas Scorilas, Louis JG Gooren, Willem de Ronde, Antoninus Soosaipillai, Erik J. Giltay, Miltiadis Paliouras, and Eleftherios P. Diamandis. "Effect of Testosterone Administration on Serum and Urine Kallikrein Concentrations in Female-to-Male Transsexuals." Clinical Chemistry 52, no. 8 (August 1, 2006): 1546–51. http://dx.doi.org/10.1373/clinchem.2006.067041.

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Abstract Background: Concentrations of human tissue kallikreins (hKs), a group of 15 secreted serine proteases found in many tissues, are modulated by steroid hormones in cancer cell lines. To gain insight into in vivo kallikrein regulation we measured kallikrein concentrations in serum and urinary tissue in female-to-male transsexuals before and after testosterone administration. Methods: We collected blood and urine samples before treatment and after 4 and 12 months from 28 female-to-male transsexuals who received 250 mg of testosterone esters intramuscularly every 2 weeks. We used ELISA assays to measure multiple kallikreins in serum and urine. Results: After testosterone administration, serum testosterone concentrations increased by ∼15-fold. Serum kallikrein concentrations increased dramatically for hK3 (prostate-specific antigen) and increased moderately for hK2, hK5, hK6, hK7, hK8, hK10, and hK11. In urine, we noted major increases for hK3 and hK2 only. For all other kallikrein concentrations, we observed no considerable changes. Conclusions: We conclude that, in serum and urine of female-to-male transsexuals after testosterone administration, hK3 (prostate-specific antigen) and to a lesser extent hK2 concentrations increase dramatically, but concentration of other kallikreins increase either moderately in serum (hK5, hK6, hK7, hK8, hK10, and hK11) or not at all in either serum (hK4, hK13, hK14) or urine (hK4, hK5, hK6, hK7, hK8, hK10, hK11, hK13, hK14).

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Dalimunthe, Ali Sahputra. "PENGARUH KUALITAS PELAYANAN JASA DAN HARGA TERHADAP LOYALITAS PELANGGAN PADA HOTEL PERMATA LAND RANTAUPRAPAT." ECOBISMA (JURNAL EKONOMI, BISNIS DAN MANAJEMEN) 4, no. 1 (October 22, 2019): 50–59. http://dx.doi.org/10.36987/ecobi.v4i1.701.

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Loyalitas Pelanggan adalah komitmen pelanggan terhadap layanan, layanan atau pemasok terdaftar (Perusahaan), berdasarkan sikap yang sangat positif dan tercermin dalam pembelian ulang yang konsisten. Loyalitas Pelanggan dapat dipengaruhi oleh banyak faktor termasuk kualitas layanan dan harga. Objek penelitian ini adalah Permata Land Rantauprapat Hotel.. Populasi dalam penelitian ini adalah konsumen yang menginap di Hotel Permata Land Rantauprapat. Sampel dalam penelitian ini adalah 98 responden. Metode pengumpulan data menggunakan kuesioner. Teknik analisis yang digunakan adalah regresi berganda. Hasil analisis regresi antara kualitas layanan til loyalitas pelanggan mendapatkan hasil positif dari 0035 hkd dan dari hasil pengujian hipotesis Menggunakan uji - t menunjukkan hasil sejumlah besar 10.532 dan up. 0,003 <a = 0,05. Hasil analisis regresi berganda antara harga kepuasan konsumen mendapatkan hasil positif dari 0734 dan dari hasil pengujian hipotesis Menggunakan uji t menunjukkan hasil sejumlah besar 11.583 dan up. 0.000 <a = 0,05. Dette kan kualitas konkluderede att layanan dan harga memiliki dampak positif dan signifikan terhadap loyalitas pelanggan.

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Xu, Shili, Tianyuan Zhou, Hanna M. Doh, K. Ryan Trinh, Art Catapang, Jason T. Lee, Daniel Braas, et al. "An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1−HK2+ Multiple Myeloma." Cancer Research 79, no. 10 (March 18, 2019): 2748–60. http://dx.doi.org/10.1158/0008-5472.can-18-2799.

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XU, WEIJUN, WEIDONG XU, HONGYI LI, and WEIGUO ZHANG. "UNCERTAINTY PORTFOLIO MODEL IN CROSS CURRENCY MARKETS." International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems 18, no. 06 (December 2010): 759–77. http://dx.doi.org/10.1142/s0218488510006787.

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Owing to the fluctuations in the financial markets, many financial variables such as expected return, volatility, or exchange rate may occur imprecisely. But many portfolio selection models consider precise input of these values. Therefore, this paper studies a multiobjective international asset allocation problem under fuzzy environment. In our portfolio selection model, both of the return risk and the exchange risk are considered. The coefficient matrices in the objectives and constraints and the decision value are considered as fuzzy variables. The calculation of the portfolio and efficient frontier is derived by considering the exchange risk in the fuzzy environment. An empirical study is performed based on a portfolio of six securities denominated in six different currencies, i.e., USD, EUR, JPY, CNY, HKD, and GBP. The α-level closed interval portfolio [Formula: see text] and the fuzzy efficient frontier are obtained with different values of α ∈ (0, 1]. The empirical results indicate that the fuzzy asset selection method is a useful tool for dealing with the imprecise problem in the real world.

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McLaren, Anne E. "Helen F. Siu, ed. Merchants’ Daughters: Women, Commerce, and Regional Culture in South China. Hong Kong: Hong Kong University Press, 2010. 375 pp. US$60/HKD 275. ISBN 978-988-8083-43-0." Nan Nü 14, no. 2 (2012): 327–30. http://dx.doi.org/10.1163/15685268-14200b12.

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Pitriyani, Pitriyani,. "PENGARUH KUALITAS PELAYANAN JASA DAN HARGA TERHADAP LOYALITAS PELANGGAN PADA HOTEL PERMATA LAND RANTAUPRAPAT." ECOBISMA (JURNAL EKONOMI, BISNIS DAN MANAJEMEN) 4, no. 2 (September 25, 2019): 125–34. http://dx.doi.org/10.36987/ecobi.v4i2.93.

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Customer Loyalty is customer commitment toward a registered, services or suppliers(Company), based on a very positive attitude and reflected in the re-purchase consistent.Customer Loyalty can be affected by many factors including the quality of service and price.The object of this research is the Permata Land Rantauprapat Hotel. The purpose of thisresearch is to analyze the influence of service quality and price of customer loyalty in the HotelPrecious Land Rantauprapat . The population in this research is the consumers who stay inHotel Permata Land Rantauprapat . The sample in this research is 98 respondents. The typeof data is the primary. Data collection method using questionnaires. The analysis techniquesused is multiple regression. The results of multiple regression analysis between the quality ofservice to the customer loyalty get the positive results of 0.035 hkd and from the results of thehypothesis test using test - t shows the results of a significant number of 10.532 and sig. 0,003<a = 0.05. The results of multiple regression analysis between the price of consumersatisfaction obtain positive results of 0,734 and from the results of the hypothesis test using test– t shows the results of a significant number of 11.583 and sig. 0,000 <a = 0.05. This can beconcluded that the quality of service and prices have positive and significant impact oncustomer loyalty

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Yasir, Muhammad, Mehr Yahya Durrani, Sitara Afzal, Muazzam Maqsood, Farhan Aadil, Irfan Mehmood, and Seungmin Rho. "An Intelligent Event-Sentiment-Based Daily Foreign Exchange Rate Forecasting System." Applied Sciences 9, no. 15 (July 25, 2019): 2980. http://dx.doi.org/10.3390/app9152980.

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Financial time series analysis is an important research area that can predict various economic indicators such as the foreign currency exchange rate. In this paper, a deep-learning-based model is proposed to forecast the foreign exchange rate. Since the currency market is volatile and susceptible to ongoing social and political events, the proposed model incorporates event sentiments to accurately predict the exchange rate. Moreover, as the currency market is heavily dependent upon highly volatile factors such as gold and crude oil prices, we considered these sensitive factors for exchange rate forecasting. The validity of the model is tested over three currency exchange rates, which are Pak Rupee to US dollar (PKR/USD), British pound sterling to US dollar (GBP/USD), and Hong Kong Dollar to US dollar (HKD/USD). The study also shows the importance of incorporating investor sentiment of local and foreign macro-level events for accurate forecasting of the exchange rate. We processed approximately 5.9 million tweets to extract major events’ sentiment. The results show that this deep-learning-based model is a better predictor of foreign currency exchange rate in comparison with statistical techniques normally employed for prediction. The results present evidence that the exchange rate of all the three countries is more exposed to events happening in the US.

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Huang, Wenjun, Lianxiu Su, Xiaoxi Zhang, Xiaoxiao Xu, and Rong Li. "Endocrinological characterization of pancreatic ducts in HFD and HGD fed mice." Journal of Cellular Biochemistry 120, no. 9 (May 13, 2019): 16153–59. http://dx.doi.org/10.1002/jcb.28896.

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Burr, Christian A., Jinjing Sun, Maria V. Yamburenko, Andrew Willoughby, Charles Hodgens, Samantha Louise Boeshore, Agustus Elmore, et al. "The HK5 and HK6 cytokinin receptors mediate diverse developmental pathways in rice." Development 147, no. 20 (October 7, 2020): dev191734. http://dx.doi.org/10.1242/dev.191734.

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ABSTRACTThe phytohormone cytokinin regulates diverse aspects of plant growth and development. Our understanding of the metabolism and perception of cytokinin has made great strides in recent years, mostly from studies of the model dicot Arabidopsis. Here, we employed a CRISPR/Cas9-based approach to disrupt a subset of cytokinin histidine kinase (HK) receptors in rice (Oryza sativa) in order to explore the role of cytokinin in a monocot species. In hk5 and hk6 single mutants, the root growth, leaf width, inflorescence architecture and/or floral development were affected. The double hk5 hk6 mutant showed more substantial defects, including severely reduced root and shoot growth, a smaller shoot apical meristem, and an enlarged root cap. Flowering was delayed in the hk5 hk6 mutant and the panicle was significantly reduced in size and infertile due to multiple defects in floral development. The hk5 hk6 mutant also exhibited a severely reduced cytokinin response, consistent with the developmental phenotypes arising from a defect in cytokinin signaling. These results indicate that HK5 and HK6 act as cytokinin receptors, with overlapping functions to regulate diverse aspects of rice growth and development.

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Leily Nurul Komariah, Heriyanto, A. Zulkarnain Ariko, and Fitra Armando. "Monitoring fouling dan jadwal pembersihan condenser dalam crude distiller unit pada pabrik pengilangan minyak bumi." Jurnal Teknik Kimia 24, no. 2 (July 1, 2018): 40–46. http://dx.doi.org/10.36706/jtk.v24i2.430.

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Crude Distiller Unit (CDU) adalah bagian penting dipakai pada hampir semua unit kilang minyak bumi. CDU berfungsi untuk memfraksionasikan crude oil menjadi senyawa sederhana untuk diumpankan ketahap selanjutnya sebagai bahan baku padasecondary process. Pada CDU dilakukan proses pengolahan crude hingga menjadi produk-produk seperti crude butane, SR Tops, Naphtha II, Naphtha III, Naphtha IV, LKD, HKD, LCT, HCT, dan umpan High Vacuum Unit. Produk Seperti SR tops output kolom 3-1 dikondensasikan untuk kemudian dialirkan melalui pompa ke tahap secondary process. Tipe condenser adalah vertikal dengan kondensasi pada bagian shell. SR tops melalui shell sementara air pendingin melalui tube. Fouling merupakan salah satu faktor penurunan koefisien transfer perpindahan panas, dimana fouling merupakan akumulasi dari deposit material pada dinding transfer panas. Dengan menggunakan metode observasi dan interview didapati data-data mengenai kondisi operasi condenser 5-1. Sementara dengan metode referensi untuk mencari data-data yang diperlukan untuk melakukan perhitungan dan study literature untuk korelasi hasil yang didapat. Hasil perhitungan dengan data aktual menunjukan bahwa sekitar 39 bulan lagi adalah waktu maksimal operasi condenser sebelum di cleaning. Hal ini sesuai dengan teori yang ada dimana waktu normal pengoperasi condenser ialah berkisar antara 3-4 tahun untuk selanjutnya di cleaning.Sementara dengan mengganti air pendingin yang semula air sungai menjadi air yang telah ditreatment didapat bahwa condenser mampu beroperasi hingga 137 bulan lagi untuk selanjutnya dilakukan cleaning. Hal ini menunjukan penggantian jenis pendingin yang digunakan berpengaruh besar dalam pengurangan rate fouling pada condenser. Sehingga perlu adanya upaya penggantian air pendingin sehingga waktu operasi alat lebih optimal.

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Kim, Hoyeun, Sang Hyeon Na, So-Young Lee, Young-Min Jeong, Hyun-Ju Hwang, Jae Young Hur, Sang-Hyun Park, Je-Chang Woo, and Sang-Gu Kim. "Structure–function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana." Biochemical Journal 443, no. 1 (March 14, 2012): 49–56. http://dx.doi.org/10.1042/bj20111308.

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TDP1 (tyrosyl-DNA phosphodiesterase 1), a member of the PLD (phospholipase D) superfamily, catalyses the hydrolysis of a phosphodiester bond between a tyrosine residue and the 3′-phosphate of DNA. We have previously identified and characterized the AtTDP gene in Arabidopsis thaliana, an orthologue of yeast and human TDP1 genes. Sequence alignment of TDP1 orthologues revealed that AtTDP has both a conserved C-terminal TDP domain and, uniquely, an N-terminal SMAD/FHA (forkhead-associated) domain. To help understand the function of this novel enzyme, we analysed the substrate saturation kinetics of full-length AtTDP compared with a truncated AtTDP mutant lacking the N-terminal FHA domain. The recombinant AtTDP protein hydrolysed a single-stranded DNA substrate with Km and kcat/Km values of 703±137 nM and (1.5±0.04)×109M−1·min−1 respectively. The AtTDP-(Δ1–122) protein (TDP domain) showed kinetic parameters that were equivalent to those of the full-length AtTDP protein. A basic amino acid sequence (RKKVKP) within the AtTDP-(Δ123–605) protein (FHA domain) was necessary for nuclear localization of AtTDP. Analysis of active-site mutations showed that a histidine and a lysine residue in each of the HKD motifs were critical for enzyme activity. Vanadates, inhibitors of phosphoryl transfer reactions, inhibited AtTDP enzymatic activity and retarded the growth of an Arabidopsis tdp mutant. Finally, we showed that expression of the AtTDP gene could complement a yeast tdp1Δrad1Δ mutant, rescuing the growth inhibitory effects of vanadate analogues and CPT (camptothecin). Taken together, the results of the present study demonstrate the structure-based function of AtTDP through which AtTDP can repair DNA strand breaks in plants.

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Deperthes, David, François Marceau, Gilles Frenette, Claude Lazure, Roland R. Tremblay, and Jean Y. Dubé. "Human kallikrein hK2 has low kininogenase activity while prostate-specific antigen (hK3) has none." Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1343, no. 1 (November 1997): 102–6. http://dx.doi.org/10.1016/s0167-4838(97)00135-0.

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Пудова, Е. А., А. В. Снежкина, М. В. Ермощенкова, С. Л. Харитонов, А. С. Сухотько, М. С. Федорова, А. Ф. Садритдинова, et al. "Экспрессия генов HK1 и HK2 при тройном негативном и люминальном А раке молочной железы." Биологические мембраны: Журнал мембранной и клеточной биологии 35, no. 5 (2018): 403–6. http://dx.doi.org/10.1134/s0233475518040126.

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Kang, Mingyu, Sang Min Lee, Wanil Kim, Kyung-Ha Lee, and Do-Yeon Kim. "Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2." Biochemical and Biophysical Research Communications 512, no. 1 (April 2019): 93–99. http://dx.doi.org/10.1016/j.bbrc.2019.03.005.

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Sato, Haruo, Roi Tsujimoto, Isumaro Kumadaki, Masatoshi Nishi, Kenichi Ido, and Ken Kimura. "Structure and Synthesis of 31-Hydroxyethyl-8-vinyldeuteroporphyrin (HVD)." JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 6, no. 3 (1986): 129–32. http://dx.doi.org/10.2530/jslsm1980.6.3_129.

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Egelrud, T., M. Brattsand, P. Kreutzmann, M. Walden, K. Vitzithum, U. C. Marx, W. G. Forssmann, and H. J. Magert. "hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6." British Journal of Dermatology 153, no. 6 (December 2005): 1200–1203. http://dx.doi.org/10.1111/j.1365-2133.2005.06834.x.

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Bourgeois, Luc, Michèle Brillard-Bourdet, David Deperthes, Maria A. Juliano, Luiz Juliano, Roland R. Tremblay, Jean Y. Dubé, and Francis Gauthier. "Serpin-derived Peptide Substrates for Investigating the Substrate Specificity of Human Tissue Kallikreins hK1 and hK2." Journal of Biological Chemistry 272, no. 47 (November 21, 1997): 29590–95. http://dx.doi.org/10.1074/jbc.272.47.29590.

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Frenette, Gilles, Roland R. Tremblay, Claude Lazure, and Jean Y. Dube. "Prostatic kallikrein hK2, but not prostate-specific antigen (hK3), activates single-chain urokinase-type plasminogen activator." International Journal of Cancer 71, no. 5 (May 29, 1997): 897–99. http://dx.doi.org/10.1002/(sici)1097-0215(19970529)71:5<897::aid-ijc31>3.0.co;2-2.

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Yip, Paul, Mengni Chen, Bing Kwan So, Kwok Fai Lam, and Kam Pui Wat. "Optimal Strategies for Reducing Number of People in the Social Security System." International Journal of Environmental Research and Public Health 17, no. 4 (February 18, 2020): 1305. http://dx.doi.org/10.3390/ijerph17041305.

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Providing social security to the population in need has become a major expenditure for many governments. Reducing the number of dependents in the social security system and maintaining a dynamic economically active population is a high priority concern for policymakers. A good understanding of the dynamics of the social security system—specifically, who enters and who exits the system—would be helpful for formulating effective interventions. Here, we made use of the data of Hong Kong’s Comprehensive Social Security Assistance (CSSA), which is currently a basic welfare scheme in Hong Kong that provides supplementary payments to households that cannot support themselves financially. We proposed a stochastic model to examine the in- and out- movement in the CSSA scheme and conducted elasticity analyses. The elasticity analyses allowed us to identify the potential target groups of people that would lead to the largest reduction in the number of the CSSA recipients in the system. This analytical method can also reveal whether policies would be more effective in preventing people from entering the CSSA system or helping them leave the CSSA scheme. Our analyses suggest that targeting those aged 30–49 with children would have the largest impact. Additionally, we found that policies that aim to prevent this group from entering the CSSA system would be more effective in reducing the number of CSSA recipients compared with policies that aim to help them exit. In contrast, for the younger age group of 10–29, policies that help them leave CSSA would be more effective than policies that prevent them from entering CSSA. Providing employment for those unemployed in this younger group would be more effective. The results indicate that by tailoring measures to specific subgroups, the overall number of CSSA recipients would be reduced, thereby improving the efficiency of Hong Kong’s social security system, which has accounted for more than 16.5% of Hong Kong government expenditure in 2018, amounting to more than HKD 92 billion.

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Savchenko, M., and L. Tsybrii. "Financial centers of new industrial countries in the world financial architecture." Galic'kij ekonomičnij visnik 70, no. 3 (2021): 188–99. http://dx.doi.org/10.33108/galicianvisnyk_tntu2021.03.188.

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The views of scholars concerning the definition of «international financial center», which makes it possible to formulate the definition of international financial center essence are summarized in this paper. The factors influencing the formation of international financial center incluing: stable financial system, stable currency, exchange rate stability, political and social stability in the country, favorable geographical location, developed financial infrastructure, open economy for free movement of capital, etc. are identified. The role of international financial centers in increasing their global competitiveness, achieving higher levels of economic growth, prosperity and social progress is substantiated. The classification of international financial centers is investigated. The place of the Hong Kong Financial Center in the financial architecture of the world is determined. The main parameters of the current state of the Hong Kong Financial Center: the USD / HKD exchange rate, the effective exchange rate index weighted by trade, the Hang Seng index, market capitalization, etc. are diagnosed. SWOT-analysis of the Hong Kong Financia Cente is carried out in order to identify its strengths, weaknesses, opportunities and threats. Based on the results of the problem of its functioning, a set of measures to improve competitiveness is also proposed. Hong Kong has favorable macroeconomic and institutional environment, qualified personnel, and is the fifth most competitive international financial center in the world. However, there is a low degree of international element in the domestic stock market, there is also risk of losing the status of «international financial center», other regional economies that have greater access to international investment opportunities in the stock market, such as Singapore, may be a threat. The financial center should focus on overcoming the effects of the coronavirus, promote the share of foreign investment in the economy, take a set of measures to overcome the country's recession, review legal, regulatory and tax requirements to promote development, improve quality of life and attractiveness, and become Asia's leading currency hub.

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Väisänen, V., J. Lövgren, J. Hellman, T. Piironen, H. Lilja, and K. Pettersson. "Characterization and processing of prostate specific antigen (hK3) and human glandular kallikrein (hK2) secreted by LNCaP cells." Prostate Cancer and Prostatic Diseases 2, no. 2 (March 1999): 91–97. http://dx.doi.org/10.1038/sj.pcan.4500289.

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Réhault, Sophie, Philippe Monget, Sabine Mazerbourg, Roland Tremblay, Ninette Gutman, Francis Gauthier, and Thierry Moreau. "Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3." European Journal of Biochemistry 268, no. 10 (May 15, 2001): 2960–68. http://dx.doi.org/10.1046/j.1432-1327.2001.02185.x.

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Kanai, Gisuke. "HID Lamps." JOURNAL OF THE ILLUMINATING ENGINEERING INSTITUTE OF JAPAN 82, no. 6 (1998): 398–402. http://dx.doi.org/10.2150/jieij1980.82.6_398.

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Journal articles on the topic 'HKD'

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