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1

Bauer, Gerhard, and Joseph S. Anderson. Gene Therapy for HIV. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0434-1.

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2

Vos, Jean-Michel H., ed. Viruses in Human Gene Therapy. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0555-2.

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3

Singwi, Sanjeev. HIV gene therapy using nucleases. Ottawa: National Library of Canada, 1996.

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4

Smith, Clay. Gene Therapy for HIV Infection. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-11821-4.

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5

Hengge, Ulrich R. Immunotreatment and gene therapy of HIV infection. Bremen: Uni-Med, 2004.

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6

Berkhout, Ben, Hildegund C. J. Ertl, and Marc S. Weinberg, eds. Gene Therapy for HIV and Chronic Infections. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2432-5.

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7

Virology, Conference on. HIV and other highly pathogenic viruses. San Diego: Academic Press, 1988.

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8

Canada, Canada Health and Welfare. Therapy and management of CMV in patients with HIV infection/ by Susan M.King. Ottawa: Health and Welfare Canada, 1990.

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9

Lombardi, Rocco Anthony. GAG and ENV trans-dominant mutants for use in ANTI-HIV-1 gene therapy. Ottawa: National Library of Canada, 1996.

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10

Catalán, José. Psychological medicine of HIV infection. Oxford: Oxford University Press, 1995.

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11

Adrian, Burgess, Klimes Ivana, and Gazzard Brian, eds. Psychological medicine of HIV infection. Oxford: Oxford University Press, 1995.

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12

Mindel, Adrian. AIDS: A pocket book of diagnosis and management. 2nd ed. London: Arnold, 1996.

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13

Brambilla, Riccardo. Viral vector approaches in neurobiology and brain diseases. New York: Humana Press, 2013.

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14

International Washington Spring Symposium (10th 1990 George Washington University). Advances in molecular biology and targeted treatment for AIDS. New York: Plenum Press, 1991.

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15

1937-, Matsushita Masaaki, and Fukunishi Isao, eds. Cutting edge medicine and liaison psychiatry: Psychiatric problems of organ transplantation, cancer, HIV/AIDS, and genetic therapy : proceedings of the 13th Tokyo Institute of Psychiatry International Symposium held in Tokyo on 29-30 September 1998. Amsterdam: Elsevier, 1999.

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16

Juelg, Boris, and Rajesh Gandhi. HIV Cure Strategies. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0006.

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Although current antiretroviral therapy (ART) is highly effective at controlling HIV-1 replication, it does not eradicate or cure the infection. HIV-1 persists quiescently in cellular reservoirs, not detected by the immune system due to the lack of active viral replication; these reservoirs represent the major obstacle for cure approaches. Reversal of HIV-1 latency and induction of virus expression by a variety of interventions may render infected cells susceptible to immune recognition and active clearance. Strategies to boost immune responses via vaccination, immunomodulation, or gene therapy are being evaluated with the aim of achieving HIV-1 control without antiretroviral therapy, if not viral eradication.
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17

H, Vos Jean-Michel, ed. Viruses in human gene therapy. Durham, N.C: Carolina Academic Press, 1995.

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18

Naicker, Saraladevi, and Graham Paget. HIV and renal disease. Edited by Vivekanand Jha. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0187_update_001.

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The human immunodeficiency virus (HIV) infection epidemic has particularly affected the poorest regions of the world. HIV can directly or indirectly affect different aspects of renal function, and results in a variable expression of kidney disease.Acute kidney injury (AKI) occurs in approximately 20% of hospitalized patients. The prevalence of chronic kidney disease (CKD) amongst HIV-infected patients is reported at 3.5–38% in different regions of the world. The complex interplay between the pheno- and/or genotypic variants of the virus, the genetic make-up of the host, and environmental factors determine the clinical manifestations of renal disease. The association of APOL1 gene variants G1 and G2 with the risk of focal segmental glomerulosclerosis explains the high frequency of HIV-associated nephropathy (HIVAN) in populations of black ethnicity.Anti-retroviral therapy (ART) is effective in preventing progression of HIVAN. Some of the drugs used in ART regimens are potentially nephrotoxic and require dose adjustment or even avoidance in CKD. Progression to end-stage renal disease (ESRD) in HIVAN has been reported to correlate with the extent of chronic damage quantified by renal biopsy.HIV-infected patients requiring dialysis, who are stable on ART, are achieving survival rates comparable to those of non-HIV dialysis populations. Similarly, HIV infection does not seem to adversely affect patient and graft survival rates after kidney transplantation, and there has been no increase in the prevalence of opportunistic infections in transplant recipients on effective ART.
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19

1957-, Smith Clay, ed. Gene therapy for HIV infection. Georgetown, Tex: R.G. Landes, 1998.

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20

Ian, Phillips M., ed. Gene therapy methods. San Diego, Calif: Academic Press, 2002.

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21

Berkhout, Ben, Hildegund C. J. Ertl, and Marc S. Weinberg. Gene Therapy for HIV and Chronic Infections. Springer, 2015.

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22

Sax, Paul E., Calvin J. Cohen, and Daniel R. Kuritzkes. HIV Essentials 2010. Jones & Bartlett Learning, 2009.

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23

Cid-Arregui, Angel. Viral Vectors: Basic Science and Gene Therapy. EATON PUBLISHING, 2000.

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24

Biloshytsky, Vadym, and Roman Cregg. Pioneering use of gene therapy for pain. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0083.

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The landmark paper discussed in this chapter is ‘Gene therapy for pain: Results of a Phase I clinical trial’, published by Fink et al. in 2011. In this study, the first of its kind, researchers studied the efficacy and safety of a modified herpes simplex virus (HSV) vector used to deliver PENK, which encodes proenkephalin, which is cleaved into the enkephalin peptides Met-enkephalin and Leu-enkephalin, which induce analgesia by acting on opioid receptors. The development of the HSV vector was based in part on results studies in which adenovirus, adeno-associated virus, or non-viral vectors were used to overexpress genes. Overexpression of a variety of large molecules leads to a reduction in pain-related behaviour in animals. Gene therapy in the treatment of chronic pain seems to offer a promising alternative to systemic or highly invasive therapies. However, additional research is needed to determine the safety, effectiveness, and cost-efficiency of this approach.
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25

(Editor), Jacqueline D. Reeves, and Cynthia A. Derdeyn (Editor), eds. Entry Inhibitors in HIV Therapy (Milestones in Drug Therapy) (Milestones in Drug Therapy). Birkhäuser Basel, 2007.

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26

A, Haseltine William, Wong-Staal Flossie, and Harvard AIDS Institute, eds. Genetic structure and regulation of HIV. New York: Raven Press, 1991.

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27

Bauer, Gerhard, and Joseph S. Anderson. Gene Therapy for HIV: From Inception to a Possible Cure. Springer, 2014.

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28

Robert, Franza B., Cullen Bryan, and Wong-Staal Flossie, eds. The Control of human retrovirus gene expression. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory, 1988.

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29

1958-, Harrington Kevin J., Pandha Hardev, and Vile Richard G, eds. Viral therapy of cancer. Chichester, West Sussex, England: John Wiley & Sons, 2007.

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30

(Editor), Richard G. Vile, and Hardev Pandha (Editor), eds. Viral Therapy of Cancer. John Wiley & Sons, 2008.

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31

(Editor), P. R. Lowenstein, and L. W. Enquist (Editor), eds. Protocols for Gene Transfer in Neuroscience: Towards Gene Therapy of Neurological Disorders. John Wiley & Sons, 1996.

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32

R, Lowenstein P., and Enquist L. W, eds. Protocols for gene transfer in neuroscience: Towards gene therapy of neurological disorders. Chichester: J. Wiley & Sons, 1996.

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33

Factor, Phillip H. Gene Therapy for Acute and Acquired Diseases. Springer, 2012.

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34

Gene Therapy for Acute and Acquired Diseases. Springer, 2001.

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35

Emini, Emilio. The Human Immunodeficiency Virus: Biology, Immunology, and Therapy. Princeton University Press, 2001.

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36

A, Emini Emilio, ed. The Human immunodeficiency virus: Biology, immunology, and therapy. Princeton, N.J: Princeton University Press, 2002.

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37

A, Machida Curtis, ed. Viral vectors for gene therapy: Methods and protocols. Totowa, N.J: Humana Press, 2003.

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38

A, Machida Curtis, ed. Viral vectors for gene therapy: Methods and protocols. Totowa, N.J: Humana Press, 2003.

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39

A, Machida Curtis, ed. Viral vectors for gene therapy: Methods and protocols. Totowa, New Jersey: Humana Press, 2003.

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40

Medina, Maria Fe C. Strategies for isolation and expression of ribozymes for use in HIV gene therapy. 2000.

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41

(Editor), Michael G. Kaplitt, and Arthur D. Loewy (Editor), eds. Viral Vectors: Gene Therapy and Neuroscience Applications. Academic Press, 1995.

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42

G, Kaplitt Michael, and Loewy Arthur D, eds. Viral vectors: Gene therapy and neuroscience applications. San Diego: Academic Press, 1995.

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43

(Editor), Michael G. Kaplitt, and Arthur D. Loewy (Editor), eds. Viral Vectors: Gene Therapy and Neuroscience Applications. Academic Press, 1995.

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44

Viral Vectors: Gene Therapy and Neuroscience Applications. Academic Press, 1995.

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45

(Editor), Michael G. Kaplitt, and Arthur D. Loewy (Editor), eds. Viral Vectors: Gene Therapy and Neuroscience Applications. Academic Press, 1995.

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46

(Editor), Boro Dropulic, and Barrie Carter (Editor), eds. Concepts in Genetic Medicine. Wiley, 2008.

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47

Concepts in genetic medicine. Hoboken, N.J: John Wiley & Sons, 2007.

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48

Machida, Curtis A. Viral Vectors for Gene Therapy: Methods and Protocols (Methods in Molecular Medicine). Humana Press, 2002.

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49

Ramezani, Ali. Development and testing of mono- and multimeric hammerhead ribozymes for HIV-1 gene therapy. 2002.

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50

G, Giraldo, ed. Development and applications of vaccines and gene therapy in AIDS. Basel: Karger, 1996.

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